Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| human papillomavirus prevalence in mouthwashes of patients undergoing tonsillectomy shows dominance of hpv69, without the corresponding finding in the tonsils. | the role of human papillomavirus (hpv) in tonsillar squamous cell carcinomas (tscc) is of interest, since a considerable proportion of tscc in sweden and other western countries is hpv positive. nevertheless, the natural history of hpv in normal tonsils, and the progression from localized infection to pre-malignant lesion to cancer are poorly understood. the aim of this study was to investigate whether hpv types found in mouthwash samples correlated to those in tonsillar tissue from the same ind ... | 2017 | 28293975 |
| influence of high risk hpv genotype on colposcopic performance: a large prospective study demonstrates improved detection of disease with zedscan i, particularly in non-hpv 16 patients. | to assess the influence of high-risk human papilloma virus (hrhpv) genotyping on the detection of high-grade disease (cin2+) using colposcopic impression both with and without electrical impedance spectroscopy (zedscan i) as an adjunct. | 2017 | 28292693 |
| human papillomavirus vaccine update. | rates of cancers attributable to human papillomavirus (hpv) are rising. a safe and extremely effective vaccine is available to prevent many of these cancers. studies have shown that health care providers' recommendation to immunize is the most important factor in parents' decision. parents of all adolescent boys and girls should receive a strong and unequivocal recommendation to vaccinate their child against hpv at the 11- or 12-year-old well child visit. ideally, adolescents complete their hpv ... | 2017 | 28292448 |
| transoral robotic surgery with radial forearm free flap reconstruction: case control analysis. | the resection of large oropharyngeal tumors traditionally involves a lip-splitting mandibulotomy for adequate margin visualization and free flap reconstruction of the surgical defect. transoral robotic surgery (tors) has emerged as a technique that can resect large and complex oropharyngeal tumors, avoiding a lip-splitting approach. the aim of this study is to compare the lip-splitting mandibulotomy approach versus tors for the management of advanced stage oropharyngeal carcinomas. | 2017 | 28292318 |
| performing piety in sexual health research: gender, health and evangelical christianities in a mexican human papillomavirus (hpv) study. | recent research suggests that health surveillance experiences like clinical trial participation might have unanticipated social consequences. i investigate how evangelical christians participating in longitudinal, observational sexual health research incorporate that long-term medical surveillance into their religious practice. this exploratory research focuses on mexican cristianos' participation in the cuernavaca arm of the multinational 'human papillomavirus in men' ('him') study, which teste ... | 2017 | 28292201 |
| hpv testing in first-void urine provides sensitivity for cin2+ detection comparable to a physician-taken smear or brush-based self-sample: cross-sectional data from a triage population. | to compare sensitivity of high-risk hpv (hrhpv) and genotype detection in self-collected morning (u1) and later (u2) urine samples, brush-based self-samples (ss) and physician-taken smears (pts) for detecting cin2+ in a colposcopic referral population. | 2017 | 28391609 |
| evolving disparities in the epidemiology of oral cavity and oropharyngeal cancers. | incidence rates of head and neck cancers (hnc) associated with human papillomavirus (hpva) infection are increasing while non-hpv-associated (non-hpva) hnc cancer rates are decreasing. as nearly all sexually active individuals will acquire an hpv infection, it is important to understand epidemiologic trends of hncs associated with this sexually transmitted disease. we analyzed seer 9 (1973-2012) and 18 data (2000-2012) for hpva hncs (oropharynx area; op) and non-hpva (oral cavity area; oc). inci ... | 2017 | 28391376 |
| reproductive health screening in women with autoimmune diseases. | although the female predominance of autoimmune diseases is not completely understood, sex hormones are thought to play a role. attention to lifelong reproductive health is especially important for women with autoimmune disorders. many of these women require long-term immunosuppressive therapy that may affect their ability to clear infections, including viruses, and may alter natural tumor surveillance mechanisms. as a result, women with autoimmune diseases may have different risks for common rep ... | 2017 | 28390560 |
| evaluation of the performance of human papillomavirus testing in paired urine and clinician-collected cervical samples among women aged over 30 years in bhutan. | urine sampling may offer a less invasive solution than cervical sampling to test for human papillomavirus (hpv) for hpv vaccine impact monitoring. | 2017 | 28390433 |
| concordance of hpv-dna in cervical dysplasia or genital warts in women and their monogamous long-term male partners. | transmission of human papillomavirus (hpv) is a premise for development of cervical dysplasia and genital warts. this cross-sectional study assesses concordance of hpv types present in genital warts or cervical dysplasia in women and genital infection of their monogamous male partners in conjunction with seroprevalence of hpv-6,-11,-16 and -18 antibodies. blood was taken from both women and men, as well a smear of the urogenital area of men. hpv dna detection in women was done in fixed paraffin ... | 2017 | 28390162 |
| genotypic diversity of anogenital human papillomavirus in women attending cervical cancer screening in harare, zimbabwe. | although anogenital cancers have been on a gradual rise in developing countries in the past few decades, they have been understudied. | 2017 | 28390142 |
| identification and characterization of enhancer agonist human cytotoxic t-cell epitopes of the human papillomavirus type 16 (hpv16) e6/e7. | human papillomavirus (hpv) is associated with the etiology of cervical carcinoma, head and neck squamous cell carcinoma, and several other cancer types. vaccines directed against hpv virus-like particles and coat proteins have been extremely successful in the prevention of cervical cancer through the activation of host hpv-specific antibody responses; however, hpv-associated cancers remain a major public health problem. the development of a therapeutic vaccine will require the generation of t-ce ... | 2017 | 28389098 |
| enhanced efficacy with reduced toxicity of chemotherapy drug 5-fluorouracil by synergistic treatment with abnormal savda munziq from uyghur medicine. | abnormal savda munziq (asmq) is a traditional prescription in uyghur medicine, and its treatment of complex diseases such as tumors and asthma has been proven to be effective in uyghur medical clinical practice. the efficacy-enhancing and toxicity-reducing properties of asmq were studied on mice with transplanted cervical cancer (u27) tumors, which were treated with 5-fluorouracil (5-fu) in this work. | 2017 | 28388901 |
| retrospective study of the influence of hpv persistence on outcomes among women with high-risk hpv infections and negative cytology. | to evaluate the outcomes of women diagnosed with high-risk hpv without cytology evidence of cervical dysplasia. | 2017 | 28388819 |
| hpv-negative penile squamous cell carcinoma: disruptive mutations in the tp53 gene are common. | the majority of penile squamous cell carcinomas is caused by transforming human papilloma virus (hpv) infection. the etiology of hpv-negative cancers is unclear, but tp53 mutations have been implicated. archival tissues of 108 invasive squamous cell carcinoma from a single pathology institution in a low-incidence area were analyzed for hpv-dna and p16(ink4a) overexpression and for tp53 mutations by ion torrent next-generation sequencing. library preparation failed in 32/108 squamous cell carcino ... | 2017 | 28387325 |
| multifocal epithelial hyperplasia. | multifocal epithelial hyperplasia is a rare disease associated with human papilloma virus types 13 and 32. diagnosis is based on clinical and histopathological findings, and most lesions are asymptomatic and regress spontaneously with time. the purpose of this paper is to describe a five-year-old girl who presented with multiple intraoral lesions on the buccal mucosa and tongue, which regressed spontaneously in 15 months. | 2017 | 28387191 |
| complete genome sequence of a novel human betapapillomavirus isolated from a skin sample. | we report the genetic characterization of a new papillomavirus (hpv_mts1) isolated and fully cloned from a skin swab. the l1 open reading frame of hpv_mts1 was 85% identical to its closest human papillomavirus (hpv) type 80, which belongs to the species beta-2 of the genus betapapillomavirus, hence qualifying it as a new hpv type. | 2017 | 28360176 |
| reasons for non-initiation and non-completion of hpv vaccine among english- and spanish-speaking parents of adolescent girls: a qualitative study. | the advisory committee on immunization practices recommends routine human papillomavirus (hpv) vaccination for females aged 11-12 years, yet vaccination rates remain low. we conducted a qualitative study to understand english- and spanish-speaking parents' reasons for non-initiation or non-completion of the hpv vaccine series for their daughters. | 2017 | 28359835 |
| recent advances in understanding and preventing human papillomavirus-related disease. | high-risk human papillomaviruses (hrhpv) are responsible for anogenital and oropharyngeal cancers, which together account for at least 5% of cancers worldwide. industrialised nations have benefitted from highly effective screening for the prevention of cervical cancer in recent decades, yet this vital intervention remains inaccessible to millions of women in low- and middle-income countries (lmics), who bear the greatest burden of hpv disease. while there is an urgent need to increase investment ... | 2017 | 28357043 |
| the risk of level ib nodal involvement in oropharynx cancer: guidance for submandibular gland sparing irradiation. | xerostomia remains a common side effect of head and neck irradiation. conflicting data exist regarding the likelihood of level ib involvement for patients with oropharyngeal squamous cell cancer (opscc), and data are limited on this risk in patients with human papillomavirus-positive disease. this study examined surgically treated opscc to determine the risk of pathologic level ib nodal involvement and to identify a cohort of patients in whom ipsilateral level ib radiation therapy may be safely ... | 2017 | 28356201 |
| quadrivalent hpv vaccination and the risk of adverse pregnancy outcomes. | background the quadrivalent human papillomavirus (hpv) vaccine is recommended for all girls and women 9 to 26 years of age. some women will have inadvertent exposure to vaccination during early pregnancy, but few data exist regarding the safety of the quadrivalent hpv vaccine in this context. methods we assessed a cohort that included all the women in denmark who had a pregnancy ending between october 1, 2006, and november 30, 2013. using nationwide registers, we linked information on vaccinatio ... | 2017 | 28355499 |
| erratum to: options in human papillomavirus (hpv) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative hpv-dna assay in ghana. | [this corrects the article doi: 10.1186/s40661-017-0041-1.]. | 2017 | 28352472 |
| distribution of human papillomavirus genotypes in cervical lesions. | the aims of the present study were to investigate the distribution of human papillomavirus (hpv) genotypes in cervical lesions, and the association between different hpv genotypes and cervical lesions. between january 2013 and june 2014, the hpv type determinations of nucleic acid by use of fluorescence polymerase chain reaction (pcr) method of 15,192 outpatients in china-japan friendship hospital were performed and the infection status was analyzed. the results showed that: i) 2,366 cases were ... | 2017 | 28352328 |
| estimation of health state utilities in breast cancer. | the aim of this study is to determine the utility of breast cancer health states using the standard gamble (sg) and visual analog scale (vas) methods in the korean general population. | 2017 | 28352159 |
| human papillomavirus (hpv) 16 antibodies at diagnosis of hpv-related oropharyngeal cancer and antibody trajectories after treatment. | despite the fact that hpv-driven oropharyngeal cancer (hpv-opc) has relatively low recurrence rates, intensive post-therapy monitoring remains the standard of care. post-treatment biomarkers are needed to risk stratify hpv-opc patients for more individualized surveillance intensity and which remain at higher recurrence risk. | 2017 | 28351584 |
| oropharyngeal cancer prognosis by tumour hpv status in france: the multicentric papillophar study. | to evaluate the impact of human papillomavirus (hpv) status, tobacco smoking and initial treatment approach on progression-free survival (pfs) and overall survival (os) for oropharyngeal cancer (opc) in france, a country where smoking declines started late (1990s). | 2017 | 28351578 |
| high-dose versus weekly cisplatin definitive chemoradiotherapy for hpv-related oropharyngeal squamous cell carcinoma of the head and neck. | to compare the outcomes and toxicity of high-dose cisplatin (hdc) versus weekly cisplatin (wc) definitive chemoradiotherapy (crt) for patients with human papillomavirus (hpv) related oropharyngeal squamous cell carcinoma (sccopx). | 2017 | 28351577 |
| rising incidence of oral tongue cancer among white men and women in the united states, 1973-2012. | despite significant reductions in tobacco use in the us, oral tongue cancer incidence has reportedly increased in recent years, particularly in young white women. we conducted age-period-cohort analyses to identify birth cohorts that have experienced increased oral tongue cancer incidence, and compared these with trends for oropharyngeal cancer, a cancer caused by human papillomavirus (hpv) that has also recently increased. | 2017 | 28351569 |
| is there an increased risk of cancer among spouses of patients with an hpv-related cancer: a systematic review. | high-risk human papillomaviruses (hr-hpv) are the cause of most ano-genital cancers and a fast growing subset of oropharyngeal cancer. as these malignancies occur as a result of an hpv- infection transmitted through intimate contact, many patients with hpv- induced cancer and their partners are concerned about hpv-transmission and the potential partners' cancer risk. few studies have addressed this issue and whether the hpv-related cancer risk of partners of patients with hpv-related cancers is ... | 2017 | 28351568 |
| role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma. | so far, no data is available on the role of the tumor stem cell marker doublecortin-like kinase 1 (dclk1) in head and neck squamous cell carcinoma (hnscc). the purpose of this study was to evaluate dclk1 expression in hnscc patients that underwent surgery and postoperative radiotherapy, and to assess its potential as a therapeutic target in vitro. | 2017 | 28351564 |
| sensitivity of tumor surface brushings to detect human papilloma virus dna in head and neck cancer. | human papilloma virus (hpv) induced head and neck squamous cell carcinoma (hnscc) represents a distinct tumor subset. we questioned how accurately a brushing from the tumor surface detects hpv in patients with hnscc. | 2017 | 28351563 |
| dying for love: perimenopausal degeneration of vaginal microbiome drives the chronic inflammation-malignant transformation of benign prostatic hyperplasia to prostatic adenocarcinoma. | prostatic carcinoma is the second commonest cancer in males and is so common as to become almost holoendemic with advancing age. the recent demonstration that far from being benign, "benign" prostatic hypertrophy is a likely a reaction of the prostate to chronic untreated lower genital tract infection, and that this chronic inflammation is likely the usual precursor to the frequent occurrence of prostatic carcinoma has far reaching implications. the obvious source for the chronic inflammatory st ... | 2017 | 28351489 |
| systematic review of cost-effectiveness analyses for combinations of prevention strategies against human papillomavirus (hpv) infection: a general trend. | due to the arrival of multi-valent hpv vaccines, it is more and more important to have a better understanding of the relationship between vaccination and screening programmes. this review aimed to: (1) collect published evidence on the cost-effectiveness profile of different hpv prevention strategies and, in particular, those combining vaccination with changes in screening practices; (2) explore the cost-effectiveness of alternative preventive strategies based on screening and vaccination. | 2017 | 28351348 |
| promoting vaginal distribution of e7 and mcl-1 sirna-silencing nanoparticles for cervical cancer treatment. | there is an urgent need to develop a less aggressive and more effective treatment against cervical lesions induced by different high-risk human papillomavirus (hr-hpv). we investigated the potential of a cocktail of small interfering rna (sirna) directed against the oncoprotein e6 (e6), the oncoprotein e7 (e7), or the antiapoptotic protein mcl-1 (mcl-1). the combination of sirna anti-e7 and anti-mcl-1 demonstrated high efficacy on multiple hpv16 and hpv18 cell lines and no effects on healthy ker ... | 2017 | 28350964 |
| prevalence and predictors of unsatisfactory anal cytology tests in a cohort of gay and bisexual men in sydney, australia: baseline findings from the study of the prevention of anal cancer (spanc). | anal cytology has been suggested as a screening test for the anal cancer precursor high-grade squamous intraepithelial lesion (hsil). we aimed to assess the prevalence and predictors of initial unsatisfactory anal cytology tests ('unsats'). the study of the prevention of anal cancer is a natural history study of anal human papillomavirus (hpv) and precancerous lesions among gay and bisexual men (gbm) of at least 35 years in sydney, australia. at each study visit, an anal swab is collected for cy ... | 2017 | 28350724 |
| effects of irradiation on human leukocyte antigen class i expression in human papillomavirus positive and negative base of tongue and mobile tongue squamous cell carcinoma cell lines. | human papillomavirus (hpv) infection is a risk factor for oropharyngeal cancer, besides smoking and alcohol. patients with hpv-positive tumors have a better prognosis than those with hpv-negative tumors. furthermore, patients with hpv-positive tumors, with high cd8+ tumor infiltrating lymphocyte counts or absent/low human leukocyte antigen (hla) class i expression have the best outcome. the latter is paradoxical, since hla class i expression is important for tumor recognition. below, the hypothe ... | 2017 | 28350079 |
| the vps4 component of the escrt machinery plays an essential role in hpv infectious entry and capsid disassembly. | human papillomavirus (hpv) infection involves multiple steps, from cell attachment, through endocytic trafficking towards the trans-golgi network, and, ultimately, the entry into the nucleus during mitosis. an essential viral protein in infectious entry is the minor capsid protein l2, which engages different components of the endocytic sorting machinery during this process. the escrt machinery is one such component that seems to play an important role in the early stages of infection. here we ha ... | 2017 | 28349933 |
| strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and hpv status in penile squamous cell carcinomas: a tissue microarray study of 112 cases. | insulin-like growth factor-1 receptor (igf1r) plays a key role in cell growth and transformation. it is overexpressed in several solid tumors. this study evaluates igf1r immunoexpression in penile squamous cell carcinoma (scc). four tissue microarrays were built from formalin-fixed, paraffin-embedded blocks of 112 penile scc from paraguay. membranous igf1r expression was evaluated by immunohistochemistry using two different approaches. an h-score was calculated in each spot (stain intensity by e ... | 2017 | 28349238 |
| health professional feedback on hpv vaccination roll-out in a developing country. | worldwide, zambia has the highest cervical cancer incidence rates (58.4/100,000 per year) and mortality rates (36.2/100,000 per year). the human papilloma virus (hpv) vaccine is considered a vital preventative measure against cervical cancer, particularly in sub-saharan countries, such as zambia. past research suggests health professionals' experiences with hpv vaccination rollout can have practical implications for effective delivery. | 2017 | 28291647 |
| medullary carcinoma of the penis: a distinctive hpv-related neoplasm: a report of 12 cases. | a third to half of penile invasive squamous cell carcinomas are human papillomavirus (hpv) related. warty (condylomatous), warty-basaloid, and basaloid carcinomas are the most common subtypes associated with hpv. less frequent are clear cell and lymphoepithelioma-like carcinomas. here we report a novel penile tumor associated with hpv. twelve cases were selected from 1010 penile carcinomas, part of an international hpv detection study conducted at the institut català d'oncologia, barcelona, spai ... | 2017 | 28291123 |
| deep sequencing of hpv e6/e7 genes reveals loss of genotypic diversity and gain of clonal dominance in high-grade intraepithelial lesions of the cervix. | human papillomavirus (hpv) is the carcinogen of almost all invasive cervical cancer and a major cause of oral and other anogenital malignancies. hpv genotyping by dideoxy (sanger) sequencing is currently the reference method of choice for clinical diagnostics. however, for samples with multiple hpv infections, genotype identification is singular and occasionally imprecise or indeterminable due to overlapping chromatograms. our aim was to explore and compare hpv metagenomes in abnormal cervical c ... | 2017 | 28288568 |
| lymph node activation by pet/ct following vaccination with licensed vaccines for human papillomaviruses. | while pet using f-fdg is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on f-fdg pet scans. the pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. furthermore, the addition of adjuvants to vaccines can further enhance the immune response. the presented study was designed to define lymph node activation following administration of the food an ... | 2017 | 28288041 |
| a protocol for a cluster randomised feasibility study of an adolescent incentive intervention to increase uptake of hpv vaccination among girls. | uptake of the human papillomavirus (hpv) vaccine in the uk is good, but there are pockets of the community who remain unprotected. immunisation teams usually require written parental consent for a girl to receive the vaccine. evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). incentivising girls to return consent forms is a promising approach to promoting consent form return. before testing the efficac ... | 2017 | 28286668 |
| prevalence of adeno-associated virus and human papillomavirus dna in iranian women with and without cervical cancer. | there is plenty of substantial evidence to support anti-tumor activity of viruses. adeno-associated virus (aav) may interact with human papillomavirus (hpv) to modify the risk of cervical neoplasia. the seroprevalence of aav among women with cervical cancer has been reported to be lower than healthy ones. in spite of this finding, detection of aav dna in cervical biopsies does not entirely support the inverse association between aav seropositivity and cervical cancer. this association is still c ... | 2017 | 28285965 |
| current and future techniques for human papilloma virus (hpv) testing in oropharyngeal squamous cell carcinoma. | despite a reduction in smoking and alcohol consumption, the incidence of oropharyngeal squamous cell carcinoma (opscc) is rising. this is attributed to human papilloma virus (hpv) infection and screening for hpv is now recommended in all cases of opscc. despite a variety of clinically available tests and new non-invasive test strategies there is no consensus on which technique is best. this review reports on current techniques for hpv detection in opscc and the clinical applicability of emerging ... | 2017 | 28285422 |
| prevalence and risk factors for human papillomavirus infection among chinese ethnic women in southern of yunnan, china. | dai is a major chinese ethnic minority group residing in rural areas of the southern part of yunnan. however, no data exist on the hpv prevalence and genotype distribution among dai women. | 2017 | 28284657 |
| the association between adverse pregnancy outcomes and maternal human papillomavirus infection: a systematic review protocol. | human papillomavirus (hpv) is the most prevalent genital infection, especially in young women of reproductive age. in vitro and animal model experiments provide compelling evidence of the harmful effect of hpv on pregnancy outcomes, but results from epidemiologic studies are inconclusive. we aim to determine the strength of the relationship between adverse pregnancy outcomes (apo) and hpv infection and assess its consistency across studies, by systematically reviewing the literature. | 2017 | 28284227 |
| geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in mozambique. | research has shown that the distance to the nearest immunization location can ultimately prevent someone from getting immunized. with the introduction of human papillomavirus (hpv) vaccine throughout the world, a major question is whether the target populations can readily access immunization. | 2017 | 28282648 |
| control of immune escaped human papilloma virus is regained after therapeutic vaccination. | high-risk human papillomaviruses infect the basal cells of human epithelia. there it deploys several mechanisms to suppress pathogen receptor recognition signalling, impeding the immune system to control viral infection. furthermore, infected cells become more resistant to type i and ii interferon, tumour necrosis factor-α and cd40 activation, via interference with downstream programs halting viral replication or regulating the proliferation and cell death. consequently, some infected individual ... | 2017 | 28282583 |
| measures of economic advantage associated with hpv-positive head and neck cancers among non-hispanic black and white males identified through the national cancer database. | national trends show dramatic increases in the incidence of hpv-related head and neck squamous cell carcinomas (hnsccs) among black and white males. using cases identified through the national cancer data base, we assessed factors associated with hpv 16- or 16/18 positive hnsccs among non-hispanic black and white males diagnosed in the u.s. between 2009 and 2013. | 2017 | 28282541 |
| lifetime sexual assault and sexually transmitted infections among women veterans. | women veterans report a high prevalence of sexual assault. unfortunately, there are limited data on the reproductive health sequelae faced by these women. our objective was to evaluate the association between completed lifetime sexual assault (lsa) and sexually transmitted infections (stis) among a cohort of women veterans, adjusting for sexual risk behaviors. | 2017 | 28281918 |
| who is to blame? framing hpv to influence vaccination intentions among college students. | human papillomavirus (hpv) is a prevalent sexually transmitted infection (sti) among college students. although previous research has studied hpv-related health communication strategies using various framing techniques, the goal of this study is to test how two unique message frames-whether mentioning hpv as an sti and whether to attribute the cause of infection as external or internal-would influence young adults' intentions to receive the recommended hpv vaccine. results indicate that gender a ... | 2017 | 28281783 |
| cervical carcinogenesis and immune response gene polymorphisms: a review. | the local immune response is considered a key determinant in cervical carcinogenesis after persistent infection with oncogenic, high-risk human papillomavirus (hpv) infections. genetic variation in various immune response genes has been shown to influence risk of developing cervical cancer, as well as progression and survival among cervical cancer patients. we reviewed the literature on associations of immunogenetic single nucleotide polymorphism, allele, genotype, and haplotype distributions wi ... | 2017 | 28280748 |
| the cost of developing a computerized tailored interactive multimedia intervention vs. a print based photonovella intervention for hpv vaccine education. | mobile technology is opening new avenues for healthcare providers to create and implement tailored and personalized health education programs. we estimate and compare the cost of developing an i-pad based tailored interactive multimedia intervention (timi) and a print based (photonovella) intervention to increase human papillomavirus (hpv) immunization. the development costs of the interventions were calculated using a societal perspective. direct cost included the cost of planning the study, co ... | 2017 | 28279866 |
| introduction of molecular hpv testing as the primary technology in cervical cancer screening: acting on evidence to change the current paradigm. | since being introduced in the 1940s, cervical cytology - despite its limitations - has had unequivocal success in reducing cervical cancer burden in many countries. however, we now know that infection with human papillomavirus (hpv) is a necessary cause of cervical cancer and there is overwhelming evidence from large-scale clinical trials, feasibility studies and real-world experience that supports the introduction of molecular testing for hpv as the primary technology in cervical cancer screeni ... | 2017 | 28279264 |
| approaches for triaging women who test positive for human papillomavirus in cervical cancer screening. | substantial evidence exists to support the introduction of molecular testing for human papillomavirus (hpv) as the primary technology in cervical cancer screening. while hpv testing is much more sensitive than cytology for detection of high-grade precancerous lesions, it is less specific. to improve efficiency, it is therefore recommended that a specific test (like cytology) be used in triaging hpv positive women to colposcopy. a number of studies have been conducted that support the use of cyto ... | 2017 | 28279257 |
| rna extraction method is crucial for human papillomavirus e6/e7 oncogenes detection. | human papillomavirus (hpv) dna testing plays a main role in the management of cervical cancer, however to improve the specificity in cervical screening, there is a need to develop and validate different approaches that can identify women at risk for progressive disease. nowadays, mrna expression of viral e6 and e7 hpv oncogenes stands up as a potential biomarker to improve cervical screening. we aimed to validate a method for rna extraction, detect hpv mrna expression and, assess the relationshi ... | 2017 | 28279212 |
| hpv l1 and p16 expression in cin1 to predict future cin2. | to use the biomarkers human papillomavirus (hpv) l1 and p16 to develop an algorithm that could triage the individual patient with cin1 for the risk of progression. a total of 82 patients initially diagnosed with cin1 at peking university shenzhen hospital in china had their initial and follow-up paraffin-embedded tissue blocks immune-stained for hpv l1 capsid protein and p16. for cin1, any staining of abnormal epithelium was considered positive. all patients were followed until they developed ci ... | 2017 | 28277314 |
| "we've been together. we don't have it. we're fine." how relationship status impacts human papillomavirus vaccine behavior among young adult women. | vaccination against the human papillomavirus (hpv) has the potential to significantly reduce morbidity and mortality associated with genital warts and hpv-related cancers. however, hpv vaccination rates continue to be suboptimal among the "catch-up" population of 18- to 26-year-old women. one consistent risk factor for nonvaccination is being in a relationship. this study aimed to understand how relationship status and vaccination status impact risk perceptions and perceived need for the hpv vac ... | 2017 | 28277236 |
| molecular tests potentially improving hpv screening and genotyping for cervical cancer prevention. | human papillomavirus (hpv)-related cancers can be averted by type-specific vaccination (primary prevention) and/or through detection and ablation of precancerous cervical lesions (secondary prevention). this review presents current challenges to cervical cancer screening programs, focusing on recent molecular advances in hpv testing and potential improvements on risk stratification. areas covered: high-risk (hr)-hpv dna detection has been progressively incorporated into cervix cancer prevention ... | 2017 | 28277144 |
| using community engagement to develop a web-based intervention for latinos about the hpv vaccine. | human papillomavirus (hpv) infection is pervasive among sexually active women and men, and hispanic women are at particularly high risk as they have higher rates of invasive cervical cancer compared to other racial or ethnic groups in the united states. there is a need for interventions to increase hpv vaccination among this high-risk population. this study investigated how to modify a previously developed web-based intervention that provided individually tailored information about hpv to improv ... | 2017 | 28276945 |
| is extending screening intervals safe in hpv negative women? | greater sensitivity which lowers cancer incidence (rocco et al, lancet 2014), extended screening intervals, and prophylactic vaccination provide the rationale for high risk human papillomavirus (hr-hpv) testing to replace cytology as the primary test in cervical screening programmes both in the uk and internationally. zorzi et al report in the bjog, a timely cohort study from italy of primary hpv cervical screening, concluding that following primary hpv screening, three years is too soon for a r ... | 2017 | 28276149 |
| cervical cancer screening and treatment in uganda. | cervical cancer is the leading cause of cancer death among women in uganda. given the high prevalence of genital human papillomavirus infection, the current unavailability of radiotherapy, and the absence of a national cervical cancer prevention and control program, these deaths will likely increase. efforts to organize an effective cervical cancer screening and treatment program will require adequate financial resources, the development of infrastructure, training needed manpower, and surveilla ... | 2017 | 28275695 |
| the deacetylase sirt1 regulates the replication properties of human papillomavirus 16 e1 and e2. | human papillomaviruses (hpv) replicate their genomes in differentiating epithelium using the viral proteins e1 and e2 in association with host proteins. while the roles of e1 and e2 in this process are understood, the host factors involved and how they interact with and regulate e1-e2 are not. our previous work identified the host replication and repair factor topbp1 as an e2 partner protein essential for optimal e1-e2 replication and for the viral life cycle. the role of topbp1 in host dna repl ... | 2017 | 28275188 |
| human papillomavirus (hpv) vaccine initiation in minority americans. | transmission of the human papillomavirus (hpv) is a significant public health concern. hpv is preventable through a series of vaccinations; however, knowledge gaps exist as to which groups are least likely to initiate vaccination. considering this gap, the aim of this study is to examine hpv vaccine initiation rates in racial minorities, comparing foreign-born individuals to their american-born peers. | 2017 | 28274389 |
| comparison of posttransplant dermatologic diseases by race. | the risk for skin cancer has been well characterized in white organ transplant recipients (otrs); however, most patients on the waiting list for organ transplant in the united states are nonwhite. little is known about cutaneous disease and skin cancer risk in this otr population. | 2017 | 28273280 |
| glycyrrhiza uralensis water extract enhances dendritic cell maturation and antitumor efficacy of hpv dendritic cell-based vaccine. | licorice has been used as herbal medicine and natural sweetener. here, we prepared glycyrrhiza uralensis water extract (guwe) and investigated the effect of guwe on the maturation and function of dendritic cells (dcs) and its adjuvant effect on dc-based vaccine. we observed that guwe dose-dependently promoted dc maturation and cytokine secretion through tlr4 signaling pathway. the capacity of dc to stimulate allogenic splenocyte proliferation was also enhanced by guwe treatment. compared with co ... | 2017 | 28272545 |
| colorimetric detection of 23 human papillomavirus genotypes by loop-mediated isothermal amplification. | human papillomavirus (hpv) infection is linked to cervical cancer. with the technological development of molecular biology and epidemiology, detection and treatment of hpv has become an important mean to prevent cervical cancer. | 2017 | 28271692 |
| human papillomavirus (hpv) e6/e7 mrna detection in cervical exfoliated cells: a potential triage for hpv-positive women. | cytology triage has been generally recommended for human papillomavirus (hpv)-positive women, but is highly dependent on well-trained cytologists. the present study was designed to explore whether hpv e6/e7 mrna detection in cervical exfoliated cells can be a potential triage for hpv-positive women from a clinic-based population. both the primary hpv testing and papanicolaou (pap) test were performed on all eligible hpv-positive women. hpv e6/e7 mrna was detected by quantivirus(®) hpv e6/e7 mrna ... | 2017 | 28271661 |
| prognostic value of human papillomavirus 16/18 genotyping in low-grade cervical lesions preceded by mildly abnormal cytology. | histological low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (lsil/cin1) preceded by normal or mildly abnormal cytology is recommended for conservative follow-up, with no separated management. in this study, we assessed the triage value of human papillomavirus (hpv) 16/18 genotyping in 273 patients with lsil/cin1. hpv16/18 genotyping was performed at baseline and follow-up was at 6-monthly intervals for up to 2 years. at each follow-up, women positive for cyt ... | 2017 | 28271660 |
| outcomes of hpv-related nasal squamous cell carcinoma. | human papilloma virus (hpv) infection has been shown to play an integral role in the development and prognosis of various head and neck cancers. generational changes in sexual behavior may have led to an increased incidence of positivity in recent years. hpv positivity in both benign and malignant lesions of the sinonasal cavities has been shown in previous studies (estimates range from 20%-30% for malignancy). we intend to investigate if hpv positivity affected survival outcomes in our patient ... | 2017 | 28271500 |
| confirmation of the eighth edition of the ajcc/uicc tnm staging system for hpv-mediated oropharyngeal cancer in japan. | several studies have demonstrated that the seventh edition of the american joint committee on cancer/american joint committee on cancer (ajcc/uicc) tnm staging system does not consistently distinguish between prognostic subgroups for human papillomavirus (hpv)-mediated oropharyngeal squamous cell carcinoma (opscc). the eighth edition of the ajcc/uicc tnm staging system came into effect for use with hpv-mediated opscc on or after 1 january 2017. this study confirms that the eighth edition of the ... | 2017 | 28271391 |
| solitary endobronchial papilloma with malignant transformation and concomitant tb infection: case report and literature review. | we are reporting a case of solitary endobronchial papilloma located in posterior segment of the left upper lobe of the lung with malignant transformation and negative human papilloma virus (hpv) strains in a 40-year-old saudi nonsmoker man. the patient had a concomitant tuberculosis (tb) infection. the patient received appropriate treatment in the form of anti-tb medication and surgical resection of the squamous cell carcinoma followed by chemotherapy. there was no evidence of tumor recurrence, ... | 2017 | 28270942 |
| options in human papillomavirus (hpv) detection for cervical cancer screening: comparison between full genotyping and a rapid qualitative hpv-dna assay in ghana. | modern cervical cancer screening increasingly relies on the use of molecular techniques detecting high-risk oncogenic human papillomavirus (hr-hpv). a major challenge for developing countries like ghana has been the unavailability and costs of hpv dna-based testing. this study compares the performance of carehpv, a semi-rapid and affordable qualitative detection assay for 14 hr-hpv genotypes, with hpv genotyping, for the detection of cytological cervical squamous intraepithelial lesions (sil). | 2017 | 28270915 |
| genetic variability in e6, e7 and l1 genes of human papillomavirus 62 and its prevalence in mexico. | human papillomavirus (hpv) is the main etiological agent of cervical cancer, the third most common cancer among women globally and the second most frequent in mexico. persistent infection with high-risk hpv genotypes is associated with premalignant lesions and cervical cancer development. hpvs considered as low risk or not yet classified, are often found in coinfection with different hpv genotypes. indeed, hpv62 is one of the most prevalent hpv detected in some countries, but there is limited in ... | 2017 | 28270859 |
| viruses in case series of tumors: consistent presence in different cancers in the same subject. | studies investigating presence of viruses in cancer often analyze case series of cancers, resulting in detection of many viruses that are not etiologically linked to the tumors where they are found. the incidence of virus-associated cancers is greatly increased in immunocompromised individuals. non-melanoma skin cancer (nmsc) is also greatly increased and a variety of viruses have been detected in nmsc. as immunosuppressed patients often develop multiple independent nmscs, we reasoned that virus ... | 2017 | 28257474 |
| determinants of geographic inequalities in hpv vaccination in the most populated region of france. | in france, there are recommendations and reimbursements for human papillomavirus (hpv) vaccination but no hpv vaccination programs. therefore, vaccination is largely determined by parents' initiative, which can lead to inequalities. the objective of this study was to determine the factors associated with poorer vaccination coverage rates in the most populated region of france. | 2017 | 28257434 |
| implementing a multipartner hpv vaccination assessment and feedback intervention in an integrated health system. | human papillomavirus (hpv) vaccine initiation rates are persistently lower than rates for other adolescent-recommended vaccines. assessment and feedback interventions are a recommended strategy for improving vaccination rates. | 2017 | 28257408 |
| human papillomavirus co-testing results effectively triage normal cervical cytology in hiv-positive women aged 30 years and older. | the aim of the study was to assess whether hiv-positive (hiv+) women aged 30 years and older with concurrent normal cervical cytology and undetectable cervical hpv have a low 3-year risk of developing cervical intraepithelial neoplasia grade 2 or higher (cin 2+) in a clinical setting. | 2017 | 28257290 |
| a pilot study into the association between oral health status and human papillomavirus-16 infection. | over the next 20 years, oropharyngeal cancers (opc) will represent the majority of head and neck cancers (hncs) in the united states. it is estimated that human papillomavirus (hpv) may account for as much as 70% to 80% of opcs in north america and in certain parts of europe. it is hence crucial to understand the disease risk factors and natural history of oral hpv infections. we hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher ... | 2017 | 28257064 |
| human papillomavirus vaccine uptake: increase for american indian adolescents, 2013-2015. | although indian health service, tribally-operated, and urban indian (i/t/u) healthcare facilities have higher human papillomavirus (hpv) vaccine series initiation and completion rates among adolescent patients aged 13-17 years than the general u.s. population, challenges remain. i/t/u facilities have lower coverage for hpv vaccine first dose compared with coverage for other adolescent vaccines, and hpv vaccine series completion rates are lower than initiation rates. researchers aimed to assist i ... | 2017 | 28256284 |
| gene promoter-associated cpg island hypermethylation in squamous cell carcinoma of the tongue. | the present study was undertaken to explore and validate novel hypermethylated dna regions in squamous cell carcinoma of the tongue (scct). genome-wide methylation changes were identified by differential methylation hybridization (dmh) microarray and validated by bisulfite genome sequencing (bgs). the results were compared against datasets from the cancer genome atlas head and neck squamous cell carcinoma (tcga-hnscc), gene expression omnibus (gse26549), and arrayexpress (e-mtab-1328). dmh ident ... | 2017 | 28255813 |
| human papillomavirus infection and cervical lesions in hiv infected women on antiretroviral treatment in thailand. | to estimate the prevalence and factors associated with human papillomavirus (hpv) infection, hpv genotypes and cytological/histological high-grade (hsil+/cin2+) lesions. | 2017 | 28254419 |
| autophagy regulates ubc9 levels during viral-mediated tumorigenesis. | ubc9, the sole e2-conjugating enzyme required for sumoylation, is a key regulator of essential cellular functions and, as such, is frequently altered in cancers. along these lines, we recently reported that its expression gradually increases during early stages of human papillomavirus (hpv)-mediated cervical lesions transformation. however, a better understanding of how ubc9 is exploited by transforming viral oncoproteins is still needed. in the present study, we show that in human samples hpv d ... | 2017 | 28253371 |
| beta human papillomavirus infection is prevalent in elephantiasis and exhibits a productive phenotype: a case-control study. | elephantiasis is considered a cutaneous region of immune deficiency with cobblestone-like surface caused by a wart-like eruption. verrucosis is a diffuse human papillomavirus (hpv) infection linked to immunodeficiency disorders. the objective of this study was to examine the prevalence of hpv infection in lymphedema and its pathogenic role in elephantiasis. a retrospective case-control study was performed examining lymphedematous skin and controls of peritumoral normal skin. hpv infection was ev ... | 2017 | 28253203 |
| [the analysis of the effectiveness of the combined treatment of the patients presenting with laryngeal papillomatosis]. | the objective of the present work was to evaluate the effectiveness of the application of the inducer of endogenous interferon synthesis in the course of the combined treatment of the adult patients presenting with laryngeal papillomatosis. a total of 50 patients with this pathology were admitted and examined at the ent clinics of i.m. sechenov first moscow state medical university and m.f. vladimirsky moscow regional research clinical institute during 24 months. the patients comprising group 1 ... | 2017 | 28252590 |
| risk factors of high-grade anal intraepithelial neoplasia recurrence in hiv-infected men who have sex with men. | to assess risk factors of high-grade anal intraepithelial neoplasia (hgain) recurrence in a cohort of hiv-infected men who have sex with men (msm). | 2017 | 28252530 |
| the role of transoral robotic surgery in the management of oropharyngeal cancer. | the rising incidence of oropharyngeal squamous cell carcinoma (opscc), in large part as a result of the human papillomavirus (hpv), has driven a movement for the change in the management strategies. renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introduction of transoral surgery, including transoral robotic surgery (tors). | 2017 | 28252460 |
| comparison of ffpe histological versus lbp cytological samples for hpv detection and typing in cervical cancer. | human papillomavirus (hpv) infection is closely associated with cervical cancer. this study analyzed hpv genotype prevalence in 75 cases of formalin-fixed paraffin embedded (ffpe) tissue samples from patients diagnosed with cervical cancer. genotype prevalence was assessed using reverse blot assay (reba) and quantitative polymerase chain reaction (qpcr), which target the hpv l1 and hpv e6/e7 genes, respectively. hpv dna chip tests were also performed using liquid based preparation (lbp) cytologi ... | 2017 | 28249711 |
| transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: updates on efficacy, surgical technique and margin status. | management of cervical unknown primary squamous cell carcinoma (cup) has evolved with the introduction of transoral robotic surgery (tors). | 2017 | 28249654 |
| validation of the icon-s staging for hpv-associated oropharyngeal carcinoma using a pre-defined treatment policy. | to determine whether the international collaboration on oropharyngeal cancer network for staging (icon-s) for hpv associated oropharyngeal carcinoma (hpv+opc) is a better discriminator of overall survival (os), compared with the 7th edition (7th ed) ajcc/uicc tnm staging following curative radiotherapy (rt). | 2017 | 28249652 |
| prevalence of human papillomavirus in tonsil brushings and gargles in cancer-free patients: the split study. | to evaluate human papillomavirus (hpv) prevalence in the tonsil using extensive ex vivo brushing and gargling in a large age-stratified sample of cancer-free patients. | 2017 | 28249648 |
| women's health care: the experiences and behaviors of rural and urban lesbians in the usa. | previous research has consistently demonstrated that, in comparison to their cisgender heterosexual counterparts, lesbians face a multitude of women's healthcare-related disparities. however, very little research has been conducted that takes an intersectionality approach to examining the potential influences of rural-urban location on the health-related needs and experiences of lesbians. the purpose of this study was to quantitatively compare rural and urban lesbians' access to women's health c ... | 2017 | 28248528 |
| a case of penile buschke-lowenstein tumor in a developing country. | buschke-löwenstein tumor is a rare manifestation of a sexually transmitted human papilloma virus infection that affects the anogenital area. wide local excision of the lesion is the mainstay of treatment. malignancy though must be excluded. | 2017 | 28265385 |
| high-risk and low-risk human papilloma virus in association to spontaneous preterm labor: a case-control study in a tertiary center, egypt. | this study aimed to detect the correlation between human papillomavirus (hpv) and spontaneous preterm labor in egyptian women and its association to the human papilloma viral load and mpp2 gene expression. | 2017 | 28264621 |
| human papillomavirus vaccine as an anticancer vaccine: collaborative efforts to promote human papillomavirus vaccine in the national comprehensive cancer control program. | widespread use of the human papillomavirus (hpv) vaccine has the potential to reduce incidence from hpv-associated cancers. however, vaccine uptake among adolescents remains well below the healthy people 2020 targets. the centers for disease control and prevention (cdc) national comprehensive cancer control program (ncccp) awardees are well positioned to work with immunization programs to increase vaccine uptake. the cdc chronic disease management information system was queried for objectives an ... | 2017 | 28263672 |
| ahns series: do you know your guidelines? management of head and neck cancer in the era of human papillomavirus: educating our patients on human papillomavirus. | human papillomavirus (hpv) has changed the face of head and neck cancer over the past 2 decades. no longer is this solely a disease of older patients with a history of heavy tobacco and alcohol use. patients with hpv-related head and neck cancers tend to be younger, healthier, and have an improved prognosis, compared with those with hpv-negative tumors. as more patients are diagnosed with hpv-related head and neck cancer, physicians have important topics to consider. these include prevalence, tr ... | 2017 | 28263449 |
| development of a replication-deficient adenoviral vector-based vaccine candidate for the interception of hpv16- and hpv18-induced infections and disease. | high-risk human papilloma virus (hpv) types are the causative agents of cervical cancer and several other anogenital malignancies. the viral proteins expressed in the (pre)malignant cells are considered ideal targets for immunological intervention. many approaches have been evaluated for this purpose, mostly aiming at the induction of hpv16 e7- and/or e6-specific cellular immunogenicity. as clinical success has so far been limited, novel approaches are required. we describe the development and p ... | 2017 | 28263390 |
| the presence of human papillomavirus in semen does not affect the integrity of sperm dna. | it remains unknown whether human papillomaviruses (hpvs) in semen affect sperm dna integrity. we investigated whether the presence of these viruses in semen was associated with an elevated sperm dna fragmentation index. semen samples of 22 normozoospermic patients undergoing infertility treatment, nine fertile donors and seven fertile men with a risk of hpv infection (genital warts or condylomas) were included in the study. the samples were examined by an inno-lipa test pcr-based reverse hybridi ... | 2017 | 28261849 |
| using twitter to understand public perceptions regarding the #hpv vaccine: opportunities for public health nurses to engage in social marketing. | given the degree of public mistrust and provider hesitation regarding the human papillomavirus (hpv) vaccine, it is important to explore how information regarding the vaccine is shared online via social media outlets. the purpose of this study was to evaluate the content of messaging regarding the hpv vaccine on the social media and microblogging site twitter, and describe the sentiment of those messages. | 2017 | 28261846 |