Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| prevention of rabies virus infection in dogs by a recombinant canine adenovirus type-2 encoding the rabies virus glycoprotein. | safe and effective vaccination is important for rabies prevention in animals. although several genetically engineered rabies vaccines have been developed, few have been licensed for use, principally due to biosafety concerns or due to poor efficacy in animal models. in this paper, we describe the construction and characterization of a replication-competent recombinant canine adenovirus type-2 expressing the rabies virus glycoprotein (srv9 strain) by a different strategy from that reported previo ... | 2006 | 16524754 |
| molecular detection of microbes in nasal tissue of dogs with idiopathic lymphoplasmacytic rhinitis. | lymphoplasmacytic rhinitis (lpr) is a common histologic finding in dogs with chronic nasal disease; however, potential etiologies of this disorder have not been examined. we investigated the hypothesis that specific microbes contribute to clinical disease in dogs with lpr. paraffin-embedded nasal biopsies were obtained from 19 dogs with lpr, 10 dogs with nasal neoplasia, and 10 dogs with nasal aspergillosis. nucleic acids were extracted from paraffin blocks, and real-time quantitative polymerase ... | 2006 | 16594580 |
| duration of immunity for canine and feline vaccines: a review. | in our studies aimed at assessing the minimum duration of vaccinal immunity (doi), approximately 1000 dogs have been vaccinated with products from all the major us veterinary biological companies. the doi for the various products is determined by antibody titers for all dogs and, by challenge studies in selected groups of dogs. recently, all major companies that make canine vaccines for the u.s. market have completed their own studies; published data show a 3 years or longer minimum doi for the ... | 2006 | 16707236 |
| cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia. | a line of dopamine-deficient (dd) mice was generated to allow selective restoration of normal dopamine signaling to specific brain regions. these dd floxed stop (ddfs) mice have a nonfunctional tyrosine hydroxylase (th) gene because of insertion of a neor gene flanked by lox p sites targeted to the first intron of the th gene. ddfs mice have trace brain dopamine content, severe hypoactivity, and aphagia, and they die without intervention. however, they can be maintained by daily treatment with l ... | 2006 | 16723393 |
| [construction and experimental immunity of recombinant replication-competent canine adenovirus type 2 expressing hemagglutinin gene of h5n1 subtype tiger influenza virus]. | h5n1 highly pathogenic avian influenza virus was highly pathogenic and sometimes even fatal for tigers and cats. to develop a new type of vaccine for felidae influenza prevention, recombinant replication-competent canine adenovirus type 2 expressing hemagglutinin gene of h5n1 subtype tiger influenza virus was constructed. a/tiger/harbin/01/2003 (hsn1) ha gene was cloned into pvax1. the ha expression cassette which included cmv and ha and polya was ligated into the e3 deletion region of pvaxdelta ... | 2006 | 16736595 |
| expression of the foot-and-mouth disease virus vp1 protein using a replication-competent recombinant canine adenovirus type 2 elicits a humoral antibody response in a porcine model. | to develop a new type vaccine for foot-and-mouth disease (fmd) prevention by using canine adenovirus as vector, the vp1 cdna of foot-and-mouth disease virus (fmdv) type o strain china 99 was amplified by rt-pcr and cloned into pegfp-c1 by replacing the gfp gene with the vp1 cdna, resulting in an expression plasmid pvp1-c1. the expression cassette of vp1 composed of the cmv promoter, the vp1 gene and the sv40 early mrna polyadenylation signal was recovered by nsi i / mlu i digestion of pvp1-c1 an ... | 2006 | 16817763 |
| structural and mutational analysis of human ad37 and canine adenovirus 2 fiber heads in complex with the d1 domain of coxsackie and adenovirus receptor. | adenovirus fibers from most serotypes bind the d1 domain of coxsackie and adenovirus receptor (car), although the binding residues are not strictly conserved. to understand this further, we determined the crystal structures of canine adenovirus serotype 2 (cav-2) and the human adenovirus serotype 37 (had37) in complex with human car d1 at 2.3 and 1.5a resolution, respectively. structure comparison with the had12 fiber head-car d1 complex showed that the overall topology of the interaction is con ... | 2006 | 16923808 |
| a single immunization with a recombinant canine adenovirus expressing the rabies virus g protein confers protective immunity against rabies in mice. | rabies vaccines based on live attenuated rabies viruses or recombinant pox viruses expressing the rabies virus (rv) glycoprotein (g) hold the greatest promise of safety and efficacy, particularly for oral immunization of wildlife. however, while these vaccines induce protective immunity in foxes, they are less effective in other animals, and safety concerns have been raised for some of these vaccines. because canine adenovirus 2 (cav2) is licensed for use as a live vaccine for dogs and has an ex ... | 2006 | 16938327 |
| three-year rabies duration of immunity in dogs following vaccination with a core combination vaccine against canine distemper virus, canine adenovirus type-1, canine parvovirus, and rabies virus. | thirty-two seronegative pups were vaccinated at 8 weeks of age with modified-live canine distemper virus (cdv), canine adenovirus type-2 (cav-2), and canine parvovirus (cpv) vaccine and at 12 weeks with a modified-live cdv, cav-2, cpv, and killed rabies virus vaccine. an additional 31 seronegative pups served as age-matched, nonvaccinated controls. all test dogs were strictly isolated for 3 years after receiving the second vaccination and then were challenged with virulent rabies virus. clinical ... | 2006 | 17039445 |
| retracted: development of recombinant canine adenovirus type-2 expressing tsol18 of porcine cysticercus. | this article has been retracted consistent with elsevier policy on article withdrawal. please see . the publisher apologizes for any inconvenience this may cause. | 2006 | 17095028 |
| comparative trial of the canine parvovirus, canine distemper virus and canine adenovirus type 2 fractions of two commercially available modified live vaccines. | the results of vaccinating two groups of puppies with commercial vaccines, both of which claimed to provide adequate protection with a final vaccination at 10 weeks of age, were compared. groups of 19 and 20 puppies with similar titres of maternally derived antibodies against canine parvovirus (cpv), canine distemper virus (cdv) and canine adenovirus type 2 (cav-2) at four weeks of age were vaccinated at six and 10 weeks of age and their responses to each vaccination were measured by comparing t ... | 2006 | 17127756 |
| the conundrum between immunological memory to adenovirus and their use as vectors in clinical gene therapy. | in the context of clinical gene transfer using viral vectors, the risk of memory antivector immunity is often poorly appreciated. the immunological past of the patient, the site of injection, and the vector dose will play intertwined and decisive roles in the safety and efficacy of treatment. to circumvent the drawbacks due to the ubiquitous human adenovirus (had) memory immunity, we believe that vectors derived from canine adenovirus type 2 (cav-2) will be more clinically useful than those deri ... | 2006 | 17172670 |
| growth characteristics of canine pathogenic viruses in mdck cells cultured in rpmi 1640 medium without animal protein. | madin darby canine kidney (mdck) cells were adapted to serum-free rpmi 1640 medium and used for cultivation of canine viruses. rpmi 1640 medium was supplemented with a soybean peptone, l-glutamine and antibiotics, so that the protein concentration was less than 5 microg/ml (rpmi/sp medium). the resulting adapted mdck-sp cells showed steady growth after the twenty-eighth passage in rpmi/sp medium (mdck-sp cell culture). canine distemper virus, canine parvovirus, canine adenoviruses and canine par ... | 2006 | 16271422 |
| pathogen exposure in endangered island fox (urocyon littoralis) populations: implications for conservation management. | island fox (urocyon littoralis) populations on four california channel islands have declined severely since 1994. canine distemper (cdv) was suspected to be responsible for the decline of the santa catalina island fox, so knowledge of infectious disease exposure in the remaining island fox populations was urgently needed. this study reviewed previous pathogen exposure in island foxes and investigated the current threat by conducting a serologic survey of foxes on all islands and sympatric feral ... | 2006 | 32226080 |
| cloning and expression of canine interferon-alpha genes in escherichia coli. | we cloned five new subtypes of cdna encoding canine interferon-alpha (caifn-alpha) from a canine epithelial cell line. caifn-alphas were divided into two groups by amino acid sequences and a molecular phylogenic tree. two subtypes of them were expressed in escherichia coli, and ifn proteins were purified. recombinant caifn-alphas were highly species-specific and showed antiviral activity against vesicular stomatitis new jersey virus and canine adenovirus-1 , but not against canine herpesvirus-1. | 2005 | 16276065 |
| frequency, proliferation, and activation of human memory t cells induced by a nonhuman adenovirus. | multiple human adenovirus (had) infections during childhood generate a memory t-cell (t(m)) response, which is the primary defense against had-induced morbidity. this cellular memory creates a conundrum for the potential clinical use of had-derived vectors: vector-mediated gene transfer is efficient in immunologically naïve mammals but will be compromised by memory immunity when using vectors derived from ubiquitous human pathogens. the potential lack of cellular and humoral memory is one reason ... | 2005 | 16282459 |
| diagnosis of infectious canine hepatitis virus (cav-1) infection in puppies with encephalopathy. | nine weaned labrador retriever puppies from a litter of 11 were presented with signs of acute central nervous system (cns) disease that included ataxia and blindness. all puppies died. gross examination of tissues from 2 puppies revealed regionally diffuse hemorrhages in the brain stem and swollen hemorrhagic lymph nodes. light microscopic examination of hematoxylin and eosin-stained tissues showed numerous large, basophilic intranuclear inclusion bodies within cns vascular endothelium and occas ... | 2005 | 15690952 |
| investigation into the causes of canine infectious respiratory disease: antibody responses to canine respiratory coronavirus and canine herpesvirus in two kennelled dog populations. | two training centres for working dogs were monitored for one year to determine the presence of viruses and viral antibodies and their association with canine infectious respiratory disease (cird). tonsillar swabs and serum were obtained from dogs on entry into the kennels and in regular intervals thereafter. additional samples were collected during outbreaks of cird. the swabs were examined by virus culture and pcr for canine parainfluenza virus, canine adenovirus, canine herpesvirus (chv) and c ... | 2005 | 15841339 |
| a human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy. | the development of novel therapeutic strategies is imperative for the treatment of advanced cancers like ovarian cancer and glioma, which are resistant to most traditional treatment modalities. in this regard, adenoviral (ad) cancer gene therapy is a promising approach. however, the gene delivery efficiency of human serotype 5 recombinant adenoviruses (ad5) in cancer gene therapy clinical trials to date has been limited, mainly due to the paucity of the primary ad5 receptor, the coxsackie and ad ... | 2005 | 16034451 |
| immunohistochemical detection of antigens of distemper, adenovirus and parainfluenza viruses in domestic dogs with pneumonia. | the lungs of 35 dogs that died in mexico from acute or subacute pneumonia were examined immunohistochemically for canine distemper virus (cdv), canine adenovirus (cav) and canine parainfluenza virus (cpiv), to determine their frequency and occurrence and possible associations. cdv was identified in 27 (77%) cases, cav in 20 (57%) and cpiv in 18 (51%). the most frequent dual association was that between cdv and cpiv (five cases; 14%). all three viruses, however, were identified in the same lung i ... | 2005 | 16202422 |
| infectious disease and the decline of steller sea lions (eumetopias jubatus) in alaska, usa: insights from serologic data. | serologic data were examined to determine whether infectious disease may have played a role in the decline of steller sea lions (eumetopias jubatus) in the gulf of alaska and aleutian islands, usa. available published data, unpublished data, and recent collections (1997-2000) were compared and reviewed. data were stratified by geography to compare the declining western alaskan population in the aleutian islands through eastern prince william sound to the increasing population in southeastern ala ... | 2005 | 16244061 |
| [construction of recombinant canine adenovirus type 2 expressing canine coronavirus spike glycoprotein and its immunogenicity]. | in order to construct a recombinant canine adenovirus type 2 (cav-2) expressing the spike glycoprotein of canine coronavirus (ccv), the s1 gene fragment of ccv strain dxmv, encoding major antigenic region a, b, c and d of s protein, was amplified by rt-pcr and cloned into pvax1 vector. the complete s1 expression cassette was subcloned into the shuttle vector pvaxe3, then further cloned into the backbone vector ppoly2-cav2 containing complete genome of cav-2. to gain the recombinant canine adenov ... | 2005 | 16245877 |
| acute toxoplasmosis in three wild arctic foxes (alopex lagopus) from svalbard; one with co-infections of salmonella enteritidis pt1 and yersinia pseudotuberculosis serotype 2b. | acute disseminated toxoplasmosis was diagnosed in three wild arctic foxes (alopex lagopus) that were found dead in the same locality on svalbard (norway). the animals included one adult female and two 4-months-old pups. the adult fox was severely jaundiced. necropsy revealed multifocal, acute, necrotizing hepatitis, acute interstitial pneumonia, and scattered foci of brain gliosis, often associated with toxoplasma tachyzoites. one pup also had toxoplasma-associated meningitis. in addition, the l ... | 2005 | 15563924 |
| three-year duration of immunity in dogs following vaccination against canine adenovirus type-1, canine parvovirus, and canine distemper virus. | a challenge-of-immunity study was conducted to demonstrate immunity in dogs 3 years after their second vaccination with a new multivalent, modified-live vaccine containing canine adenovirus type 2 (cav-2), canine parvovirus (cpv), and canine distemper virus (cdv). twenty-three seronegative pups were vaccinated at 7 and 11 weeks of age. eighteen seronegative pups, randomized into groups of six dogs, served as challenge controls. dogs were kept in strict isolation for 3 years following the vaccina ... | 2005 | 15906266 |
| pcr screening for candidate etiological agents of canine hepatitis. | hepatitis, either acute or chronic, is a relatively common hepatic disease in dogs. several forms of canine hepatitis can occur, some with a defined cause, most cases have an unknown etiology. the similarities between canine hepatitis and human viral hepatitis suggest that canine hepatitis may have a viral etiology too. | 2005 | 15917133 |
| prevalence of serum antibodies to canine adenovirus and canine herpesvirus in the european red fox (vulpes vulpes) in australia. | to determine the seroprevalence and aspects of the epidemiology of canine adenovirus (cadv) and canine herpesvirus (cahv-1) in european red foxes (vulpes vulpes) in australia. | 2005 | 15986915 |
| [construction and immunogenicity of recombinant canine adenovirus type 2 with the external part of glycoprotein of rabies virus]. | the cases of rabies increase greatly in recent years in china and rabies continues to be a serious problem in developing countries due to the reservoirs of rabies virus in dogs and wildlife vectors. the control of rabies depends on the development of safe, effective, economical vaccines that may be used for preexposure vaccination in animals. for this purpose, the external part of glycoprotein gene of rabies virus strain srv9 (rvg) was amplified by the rt-pcr and cloned into pegfp-c1 with replac ... | 2005 | 15989263 |
| a serologic survey for antibodies to three canine viruses in wolverines (gulo gulo) from the brooks range, alaska. | canine distemper virus (cdv), canine parvovirus type 2 (cpv-2), and canine adenovirus type 1 (cav-1) are pathogens that are typically associated with canids but may cause serious disease in a wide range of other carnivores. from 1998 to 2002, serum samples from 64 wolverines (gulo gulo) from the brooks range, alaska, were tested for antibodies to cdv, cpv-2, and canine adenovirus (cav). four animals tested positive for antibodies to cdv (7%), one for antibodies to cpv-2 (2%), and none for antibo ... | 2005 | 16456170 |
| fluorescently tagged canine adenovirus via modification with protein ix-enhanced green fluorescent protein. | canine adenovirus type 2 (cav2) has become an attractive vector for gene therapy because of its non-pathogenicity and the lack of pre-existing neutralizing antibodies against this virus in the human population. additionally, this vector has been proposed as a conditionally replicative adenovirus agent under the control of an osteocalcin promoter for evaluation in a syngeneic, immunocompetent canine model with spontaneous osteosarcoma. in this study, a cav2 vector labelled with the fluorescent ca ... | 2005 | 16298964 |
| exposure of free-ranging maned wolves (chrysocyon brachyurus) to infectious and parasitic disease agents in the noël kempff mercado national park, bolivia. | maned wolves (chrysocyon brachyurus) are neotropic mammals, listed as a cites appendix ii species, with a distribution south of the amazon forest from bolivia, through northern argentina and paraguay and into eastern brazil and northern uruguay. primary threats to the survival of free-ranging maned wolves include habitat loss, road kills, and shooting by farmers. an additional threat to the conservation of maned wolves is the risk of morbidity and mortality due to infectious and parasitic diseas ... | 2005 | 17323558 |
| evaluation of the efficacy and duration of immunity of a canine combination vaccine against virulent parvovirus, infectious canine hepatitis virus, and distemper virus experimental challenges. | the results of this study confirmed that dogs vaccinated subcutaneously with a commercially available multivalent vaccine containing modified-live canine distemper virus, canine adenovirus type 2, canine parvovirus type 2b, and canine parainfluenza virus antigens were protected against sequential experimental challenge 55 to 57 months after initial vaccination given at 7 to 8 weeks of age. all 10 vaccinates were protected against clinical diseases and mortality following parvovirus and infectiou ... | 2004 | 15578450 |
| serologic survey for canine infectious diseases among sympatric swift foxes (vulpes velox) and coyotes (canis latrans) in southeastern colorado. | swift foxes (vulpes velox) and coyotes (canis latrans) are sympatric canids distributed throughout many regions of the great plains of north america. the prevalence of canid diseases among these two species where they occur sympatrically is presently unknown. from january 1997 to january 2001, we collected blood samples from 89 swift foxes and 122 coyotes on the us army piñon canyon maneuver site, las animas county, se colorado (usa). seroprevalence of antibodies against canine parvovirus (cpv) ... | 2004 | 15650093 |
| long-term in vivo transduction of neurons throughout the rat cns using novel helper-dependent cav-2 vectors. | numerous genetic and environmental causes, variable pathophysiologies, and the blood-brain barrier create a formidable challenge for the study and treatment of neurodegenerative diseases affecting the central nervous system. although there are many intracellular strategies to address neurodegeneration, for example, which transgene to use, one fundamental criterion for the long-term survival of neurons may be their genetic modification. here, we describe the generation and in vivo efficacy of hel ... | 2004 | 14688208 |
| duration of serologic response to five viral antigens in dogs. | to determine whether vaccinated dogs either remained seropositive or responded serologically to revaccination for 5 key viral antigens after extended periods since their last vaccination. | 2004 | 14710876 |
| serological survey of selected pathogens of free-ranging foxes in southern argentina, 1998--2001. | a serological survey was conducted in the patagonia region of argentina to estimate the prevalence of nine disease agents within the populations of free-ranging culpeo (dusicyon culpaeus) and grey (dusicyon griseus) foxes. the disease agents were aujeszky's disease virus (adv), brucella, canine adenovirus (cav), canine distemper virus (cdv), canine parvovirus (cpv), encephalitozoon cuniculi, leptospira, neospora caninum, and toxoplasma gondii. a total of 84 foxes were sampled (28 culpeo and 56 g ... | 2004 | 15861875 |
| gene transfer to brain and spinal cord using recombinant adenoviral vectors. | recombinant adenoviral (ad) vectors are derived from human adenoviruses: nonenveloped, encapsidated linear, double-stranded dna viruses that commonly cause respiratory and gastrointestinal infections. forty-three different human adenovirus serotypes have been characterized. details about production of recombinant ad vectors are given in chapter 1. ad vectors in widespread use are derived from human ad serotypes 2 and 5 (ad2 and ad5), ad5 being more common for applications in the central nervous ... | 2004 | 14970587 |
| car chasing: canine adenovirus vectors-all bite and no bark? | this review deals primarily with canine adenovirus serotype 2 (cav-2) vectors and gives a simplified overview of how the various domains of virology, cellular and molecular biology, as well as immunology, come into play when trying to understand and ameliorate adenovirus (ad)-mediated gene transfer. the generation of early region 1 (e1)-deleted (deltae1) cav-2 vectors, the lack of pre-existing humoral immunity, trafficking, the use of the coxsackie b adenovirus receptor (car), the surprising neu ... | 2004 | 14978757 |
| serum antibody titres to canine parvovirus, adenovirus and distemper virus in dogs in the uk which had not been vaccinated for at least three years. | antibody titres to canine distemper (cdv), canine parvovirus (cpv) and canine adenovirus (cav) were measured in 144 adult dogs that had not been vaccinated for between three and 15 years. protective antibodies to cpv were present in 95 per cent of the population, to cdv in 71.5 per cent and to cav in 82 per cent. the prevalence of protective titres did not decrease with increasing time interval from the last vaccination for any of the three diseases studied. booster vaccination increased the dog ... | 2004 | 15119729 |
| exposure to feline and canine pathogens in bobcats and gray foxes in urban and rural zones of a national park in california. | exposure of bobcats (lynx rufus) and gray foxes (urocyon cinereoargenteus) to a range of common canine and feline pathogens was assessed in urban and rural zones of golden gate national recreation area, a national park in the san francisco bay area, (california, usa) from 1992 to 1995. testing included serology for canine distemper virus, canine parvovirus (cpv), canine adenovirus, leptospira interrogans, feline calicivirus (fcv), feline panleukopenia virus, feline herpesvirus, feline enteric co ... | 2004 | 15137484 |
| a placebo-controlled trial of two intranasal vaccines to prevent tracheobronchitis (kennel cough) in dogs entering a humane shelter. | a placebo-controlled field trial was conducted to compare the effectiveness of intranasal (in) vaccines containing bordetella bronchiseptica and canine-parainfluenza virus, with (in-bpa) or without (in-bp) canine-adenovirus type 2, for prevention of kennel cough at a humane shelter. dogs were examined on admission to the shelter and those without respiratory signs of disease were assigned daily, on a rotating basis, to receive one of three vaccines. we enrolled 972 healthy dogs. dogs were monito ... | 2004 | 15156996 |
| canine distemper and related diseases: report of a severe outbreak in a kennel. | an outbreak of canine distemper in a kennel of german shepherds in the province of bari is reported. six 42-day-old pups developed typical signs of canine distemper (fever, conjunctivitis, respiratory distress and enteritis) and died within 7-10 days. neurological symptoms were observed only in one pup. four additional pups, which had shown no sign of illness, were separated and vaccinated, but two of these developed a severe, fatal nervous form 15 days later. post-mortem examination, carried ou ... | 2004 | 15164629 |
| an adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism. | many clinically relevant tissues are refractory to ad5 transduction because of negligible levels of the primary ad5 receptor, the coxsackie and adenovirus receptor (car). thus, development of ad vectors that display car-independent tropism could lead directly to therapeutic gain. the toronto strain of canine adenovirus type 2 (cav2) exhibits native tropism that is augmented by, but not fully dependent upon, car for cellular transduction. we hypothesized that an ad5 vector containing the nonhuman ... | 2004 | 15183058 |
| antibodies to selected pathogens in free-ranging terrestrial carnivores and marine mammals in canada. | antibody titres to selected pathogens (canine adenovirus [cav-2], feline herpesvirus [fhv], phocine herpesvirus [phv-1], canine distemper virus, dolphin morbillivirus [dmv], phocine distemper virus [pdv], parainfluenza virus type 3 [pi3], rabies virus, dolphin rhabdovirus [drv], canine coronavirus, feline coronavirus, feline leukaemia virus, borrelia burgdorferi and toxoplasma gondii) were determined in whole blood or serum samples from selected free-ranging terrestrial carnivores and marine mam ... | 2004 | 15338705 |
| longitudinal study of viruses associated with canine infectious respiratory disease. | in this investigation a population of dogs at a rehoming center was monitored over a period of 2 years. despite regular vaccination of incoming dogs against distemper, canine adenovirus type 2 (cav-2), and canine parainfluenza virus (cpiv), respiratory disease was endemic. tissue samples from the respiratory tract as well as paired serum samples were collected for analysis. the development of pcr assays for the detection of cpiv, canine adenovirus types 1 and 2, and canine herpesvirus (chv) is d ... | 2004 | 15472304 |
| a canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model. | oncolytic adenoviruses, which selectively replicate in and subsequently kill cancer cells, have emerged as a promising approach for treatment of tumors resistant to other modalities. although preclinical results have been exciting, single-agent clinical efficacy has been less impressive heretofore. the immunogenicity of adenoviruses, and consequent premature abrogation of replication, may have been a partial reason. improving the oncolytic potency of agents has been hampered by the inability to ... | 2003 | 12597904 |
| serologic survey for diseases in free-ranging coyotes (canis latrans) from two ecologically distinct areas of utah. | the influence of habitat and associated prey assemblages on the prevalence of canine diseases in coyotes (canis latrans) has received scant attention. from december 1997 through december 1999, we captured 67 coyotes in two ecologically distinct areas of utah (usa): deseret land and livestock ranch and us army dugway proving ground. these areas differ in habitat and prey base. we collected blood samples and tested for evidence of various canine diseases. prevalence of antibodies against canine pa ... | 2003 | 12910777 |
| characterization of cis-acting sequences involved in packaging porcine adenovirus type 3. | encapsidation of adenovirus dna involves specific interactions between cis-acting genomic dna sequences and trans-acting proteins. the cis-acting packaging domain located near the left inverted terminal repeat is composed of a series of redundant but not functionally equivalent motifs. such motifs are made up of the consensus sequence 5'-tttgn(8)cg-3' and 5'-tttg/a-3' in human adenovirus 5 (hav-5) and canine adenovirus-2 (cav-2), respectively. to gain comparative insight into adenovirus encapsid ... | 2003 | 14554092 |
| [canine adenovirus: useful for gene transfer in humans?]. | 2003 | 14648469 | |
| clinical and microbiologic characterization of hemorrhagic pneumonia due to extraintestinal pathogenic escherichia coli in four young dogs. | over a 21-month period, three beagle dogs and one mixed-breed dog at our facility developed fatal pneumonia. the four dogs, all purpose bred, came from three vendors and had received the standard canine vaccines prior to shipment. in each instance, the affected dog had been shipped to our facility within the past 10 days. three cases presented as a peracute clinical syndrome, and all had gross and microscopic findings consistent with hemorrhagic pneumonia. escherichia coli was isolated from the ... | 2003 | 14727816 |
| neurotropism and retrograde axonal transport of a canine adenoviral vector: a tool for targeting key structures undergoing neurodegenerative processes. | viral tropism refers to the ability of a virus to selectively infect a given subset of cells. it relies on a variety of viral and host determinants that entail virus binding and entry into target cells, in addition to the presence of genetic elements that allow or enhance viral gene expression in a specific manner. here we report the results of neuroanatomical studies in rat brains injected in different cerebral structures with vectors derived from the canine adenovirus type 2 (cav2), whose natu ... | 2002 | 11786042 |
| generation of e3-deleted canine adenoviruses expressing canine parvovirus capsid by homologous recombination in bacteria. | e3-deleted canine adenovirus type 1 (cav-1) was generated by homologous recombination in bacterial cells, using an antibiotic resistance marker to facilitate the recovery of recombinants. this marker was flanked by unique restriction endonuclease sites, which allowed its subsequent removal and the insertion of cassettes expressing the canine parvovirus capsid at the e3 locus. infectious virus was recovered following transfection of canine cells and capsid expression was observed by rt-pcr from o ... | 2002 | 11853396 |
| glomerulonephritis associated with simultaneous canine adenovirus-1 and dirofilaria immitis infection in a dog. | this article describes a case of glomerulonephritis and immunocomplex (igm, igg and c3c) deposition in the mesangium and basement membranes of a 2-year-old dog with canine viral hepatitis and dirofilariasis. the deposits observed in the mesangium were in the vicinity of cells with viral replication. however, no clear relationship was found between viral replication and the deposition of immunocomplexes in the glomerular capillary basement membranes, which may be the reason why these deposits hav ... | 2002 | 12121044 |
| vaccination of puppies born to immune dams with a canine adenovirus-based vaccine protects against a canine distemper virus challenge. | none of the currently available distemper vaccines provides a satisfactory solution for the immunization of very young carnivores in the face of maternal-derived immunity. since mucosal immunization with replication-competent adenovirus-based vaccines has been proven effective in the face of passive immunity against the vector, it has the potential to provide a solution for the vaccination of young puppies born to canine distemper virus (cdv)-immune dams. we report the engineering and the charac ... | 2002 | 12297394 |
| polymerase chain reaction analysis for viruses in paraffin-embedded myocardium from dogs with dilated cardiomyopathy or myocarditis. | to perform polymerase chain reaction (pcr) analysis on paraffin-embedded myocardium from dogs with dilated cardiomyopathy (dcm) and dogs with myocarditis to screen for canine parvovirus, adenovirus types 1 and 2, and herpesvirus. | 2001 | 11197551 |
| detection and differentiation of cav-1 and cav-2 by polymerase chain reaction. | canine adenovirus type 1 (cav-1) and type 2 (cav-2) can be categorized in the laboratory by haemagglutination and neutralization tests, but they are difficult to differentiate from each other in specimens, especially when infection occurs in the digestive tract. the object of this study was to develop a simple method of detecting and differentiating them. one pair of common primers was designed and synthesized according to the sequences of the e3 and flanking regions and a polymerase chain react ... | 2001 | 11214675 |
| characterization of cis-acting sequences involved in canine adenovirus packaging. | the cis-acting packaging domain in adenovirus serotype 5 (ad5) is a series of redundant, albeit not functionally equivalent, "a-repeats" made up of the consensus sequence 5'-tttgn(8)cg-3'. a-repeats may bind trans-acting factors that direct packaging of the adenovirus genome into the preformed capsid. to try to understand this basic mechanism, we examined the packaging domain from a nonhuman adenovirus. we delimited the canine adenovirus type 2 (cav-2) packaging domain to within 156 bp via a con ... | 2001 | 11319926 |
| expression of canine interferon-gamma by a recombinant vaccinia virus and its antiviral effect. | a recombinant vaccinia virus-expressing canine interferon (ifn)-gamma (vv/cifn-gamma) was constructed. in rabbit kidney (rk13) and canine a72 cells infected with vv/cifn-gamma, ifn activity was detected in the culture supernatants of both cell types. canine ifn-gamma was also detected in both cell extracts by western blot. the activity of the recombinant canine ifn-gamma in rk13 cells was higher than that in a72 cells. the vv/cifn-gamma could not grow in a72 cells at a low multiplicity of infect ... | 2001 | 11325466 |
| hepatic cirrhosis in a five-month-old dog. | the clinicopathological features of an unusual case of a five-month-old male spanish mastiff, which was presented with clinical signs indicative of severe hepatic failure, are reported. fluid replacement therapy, colloid plasma expanders, antibiotics and diuretic drugs were unsuccessful in improving the animal's general condition, and euthanasia was elected by the owner. on necropsy, ascites and severe cirrhosis, with extensive periacinar necrosis, was found. cirrhosis is a rare lesion in young ... | 2001 | 11380017 |
| recent epidemiological status of canine viral enteric infections and giardia infection in japan. | epidemiology of canine enteric infections was studied. rectal swabs collected from 95 dogs presented at animal hospitals during a period from january to june of 2000 were examined for enteric pathogens, including viruses and giardia lamblia (g. lamblia). most frequently detected in both diarrheal and normal feces were canine coronavirus (55.4%) and g. lamblia (48.2%). canine parvovirus type 2 (cpv-2) was specifically associated with diarrheal cases and cpv-2b was the predominant antigenic type. ... | 2001 | 11411507 |
| antibody testing against canine coronavirus by immunoperoxidase plaque staining. | the application of the immunoperoxidase (ip) plaque staining procedure (ip test) to the diagnosis of canine coronavirus (ccv) infection was investigated. the ip test did not react with sera from either 15 specific pathogen-free (spf) dogs or 7 spf dogs immunized with a multivalent vaccine, including canine parvovirus type 2, canine distemper virus, canine adenovirus type 2, and canine parainfluenza virus. to compare the ip test with the neutralizing test (nt), sera from 240 healthy dogs and from ... | 2001 | 11432433 |
| severe enteric disease in an animal shelter associated with dual infections by canine adenovirus type 1 and canine coronavirus. | an outbreak of dual infection in dogs with canine adenovirus type 1 (cav-1) and canine coronavirus (ccv) infection is reported in an animal shelter that comprised approximately 200 adults stray dogs and 30 puppies. twenty puppies died 7-8 days after the onset of the clinical signs (severe enteritis, leucopoenia, respiratory distress and dehydration). both cav-1 and ccv were isolated from tissue or swab samples. antibodies to ccv and, at high levels, to cav-1 also were detected in several puppies ... | 2001 | 11471849 |
| preferential transduction of neurons by canine adenovirus vectors and their efficient retrograde transport in vivo. | in the central nervous system (cns), there are innate obstacles to the modification of neurons: their relative low abundance versus glia and oligodendrocytes, the inaccessibility of certain target populations, and the volume one can inject safely. our aim in this study was to characterize the in vivo efficacy of a novel viral vector derived from a canine adenovirus (cav-2). here we show that cav-2 preferentially transduced i) rat olfactory sensory neurons; ii) rodent cns neurons in vitro and in ... | 2001 | 11511531 |
| immunogenicity of an e1-deleted recombinant human adenovirus against rabies by different routes of administration. | the immunogenic properties of an e1-deleted, human adenovirus type 5 (ad5) vaccine virus with activity against rabies were examined in mice, foxes and dogs using different routes of administration. nmri mice received 10(5.8), 10(5.3), 10(4.3), 10(3.3) and 10(2.3) tcid(50) by peroral or intramuscular (i.m.) administration. furthermore, six mice received 10(5.8) tcid(50) intracerebrally (i.c.). the construct elicited marked seroconversion in mice after oral administration. immunoreactivity in mice ... | 2001 | 11514729 |
| trafficking and propagation of canine adenovirus vectors lacking a known integrin-interacting motif. | canine adenovirus type 2 (cav-2) vectors may be attractive tools for gene transfer thanks to the lack of pre-existing immunity in humans, and because of the preferential transduction of neurons when the vector is injected into the brain and some innervated tissues. the coxsackievirus-adenovirus receptor (car) appears to play a major role during infection of most human serotypes, whereas the alpha(v)beta(3/5) integrins have been reported to play a significant auxiliary role. we showed that cav-2 ... | 2001 | 11560774 |
| [development of a canine adenovirus type 1 vaccine strain e3-deleted based expression vector]. | to evaluate canine adenovirus type 1 vaccine strain (cannaught laboratory limited, cll) as recombinant vaccine and gene transfer vector. | 2001 | 12905816 |
| canine adenovirus vectors: an alternative for adenovirus-mediated gene transfer. | preclinical studies have shown that gene transfer following readministration of viral vectors is often inefficient due to the presence of neutralizing antibodies. vectors derived from ubiquitous human adenoviruses may have limited clinical use because preexisting humoral and cellular immunity is found in 90% of the population. furthermore, risks associated with the use of human adenovirus vectors, such as the need to immunosuppress or tolerize patients to a potentially debilitating virus, are av ... | 2000 | 10590140 |
| cellular uptake and infection by canine parvovirus involves rapid dynamin-regulated clathrin-mediated endocytosis, followed by slower intracellular trafficking. | canine parvovirus (cpv) is a small, nonenveloped virus that is a host range variant of a virus which infected cats and changes in the capsid protein control the ability of the virus to infect canine cells. we used a variety of approaches to define the early stages of cell entry by cpv. electron microscopy showed that virus particles concentrated within clathrin-coated pits and vesicles early in the uptake process and that the infecting particles were rapidly removed from the cell surface. overex ... | 2000 | 10644365 |
| nedocromil sodium inhibits canine adenovirus bronchiolitis in beagle puppies. | nedocromil sodium is a nonsteroidal anti-inflammatory drug used to control asthmatic attacks. our hypothesis is that nedocromil sodium inhibits virus-induced airway inflammation, a common trigger of asthma. we nebulized nedocromil sodium into beagle dogs (n = 10, mean +/- sem ages: 149 +/- 13 days) before and after inoculation with canine adenovirus type 2 (cav2). control dogs (n = 10) received saline aerosols and were either infected with cav2 (sal/cav2, n = 7, mean +/- sem ages: 140 +/- 11 day ... | 2000 | 10805150 |
| the removal of viruses during the purification of equine antisera using filtration aids hyflo super-cel and fulmon super a. | the manufacturing process in australia for equine antisera against various venoms/toxins is based primarily on ammonium sulphate precipitation of pepsin-digested igg, whereby fc and f(ab')(2)fragments are separated. the capacity of the process to remove non-enveloped and enveloped model viruses was assessed using a scaled-down process. each virus was added to mid-process samples from equine plasma before the material was applied to hyflo super-celtrade mark filtration followed by fulmonttrade ma ... | 2000 | 10964443 |
| serologic survey of selected viral agents in recently captured wild north american river otters (lontra canadensis). | blood samples were collected from 64 wild north american river otters (lontra [lutra] canadensis) from northern and eastern new york state and analyzed for serologic evidence of exposure to selected viral agents during a 1995 1996 translocation program. no clinical signs of disease nor lesions suggestive of prior viral exposure were seen. titers were detected for antibodies against canine distemper virus, canine herpesvirus-1, and canine parvovirus-2 but not for antibodies against canine adenovi ... | 2000 | 10982127 |
| canine adenovirus type 2 attachment and internalization: coxsackievirus-adenovirus receptor, alternative receptors, and an rgd-independent pathway. | the best-characterized receptors for adenoviruses (ads) are the coxsackievirus-ad receptor (car) and integrins alpha(v)beta(5) and alpha(v)beta(3), which facilitate entry. the alpha(v) integrins recognize an arg-gly-asp (rgd) motif found in some extracellular matrix proteins and in the penton base in most human ads. using a canine adenovirus type 2 (cav-2) vector, we found that cho cells that express car but not wild-type cho cells are susceptible to cav-2 transduction. cells expressing alpha(m) ... | 2000 | 11044108 |
| [cloning and sequence analysis of 55 k protein of egg drop syndrome virus]. | for understanding the characteristics of genomic structure of egg drop syndrome virus(edsv). | 1999 | 12569783 |
| canine viral vaccines at a turning point--a personal perspective. | the most important canine viral infections are distemper and cpv-2. problems of variable cd vaccine safety and efficacy persist, but cd vaccines have greatly reduced the prevalence of disease and cases in vaccinated dogs are now rare. canine hepatitis (ich, cav-1 infection) also has been controlled well by vaccines for more than 35 years and it is now rare; the sporadic cases seen in the 1990s have usually occurred in unvaccinated dogs. cav-2 vaccines should, therefore, continue to be given sinc ... | 1999 | 9890023 |
| novel human gene transfer vectors: evaluation of wild-type and recombinant animal adenoviruses in human-derived cells. | major disadvantages of human adenovirus (had) vectors in gene therapy include preexisting or induced immune responses, and possible coreplication of recombinant had in the presence of wild-type hads. these disadvantages may be overcome by using nonhuman, animal adenoviruses (aads). we evaluated four different aads for their potential use as viral vectors. the canine adenovirus type 2 (cav2) and bovine adenovirus type 3 (bav3) appeared to be suitable systems, as they infect human cells. cav2, but ... | 1999 | 10566887 |
| presence of antibodies to canine distemper virus, canine parvovirus and canine adenovirus type 1 in free-ranging jackals (canis adustus and canis mesomelas) in zimbabwe. | a survey of free-ranging jackals (canis adustus and canis mesomelas) in zimbabwe was conducted to determine the prevalence of serum antibodies to canine distemper virus (cdv), canine parvovirus (cpv) and canine adenovirus type 1 (cav-1). sera from 16 canis adustus and 22 canis mesomelas were collected from 1990 to 1993 from various regions of zimbabwe and assayed by means of immunofluorescent techniques. seroprevalence in c. adustus and c. mesomelas respectively were 50% and 63.6% for cdv, 12.5% ... | 1999 | 10631712 |
| isolation and identification of canine adenovirus type-2 from the upper respiratory tract of a dog. | to report on the isolation and identification of canine adenovirus type-2 (cav-2) from a greyhound dog with tracheitis/tonsillitis. | 1998 | 16032028 |
| viral antibodies in coyotes from california. | prevalence of antibodies against canine parvovirus (cpv), canine distemper virus (cdv), and canine adenovirus type 1 (cav) were determined among 152 coyotes (canis latrans) at the naval petroleum reserves (nprc; california, usa) from 1985 to 1990. overall prevalence of antibodies to cpv, cdv, and cav was 66%, 37%, and 68%, respectively. prevalence of cpv and cdv varied significantly among years. antibody prevalence did not differ between sexes for any disease, but did vary significantly among ag ... | 1998 | 9577772 |
| seroprevalence of selected disease agents from free-ranging black bears in florida. | sera obtained from 66 free-ranging florida black bears (ursus americanus floridanus) from three geographic areas of florida (usa) between november 1993 and august 1995 were tested for antibodies to 13 disease agents. antibody prevalences were 3 positive of 37 tested (8%) coxiella burnetti, 37 of 66 (56%) toxoplasma gondii, 3 of 61 (5%) bluetongue virus/epizootic hemorrhagic disease virus (btv/ehdv), 4 of 66 (6%) canine adenovirus-type 1, 5 of 66 (8%) canine distemper virus (cdv), 10 of 62 (16%) ... | 1998 | 9706572 |
| use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. | to assess the possible involvement of canine adenovirus type 1 (cav-1) in naturally occurring cases of canine chronic liver disease, a polymerase chain reaction (pcr)-based assay was developed to detect a conserved region of the major core protein gene (pvii) of cav-1 in formalin-fixed, paraffin-embedded liver sections. results were compared with a standard avidin-biotin immunoperoxidase complex technique that detected cav-1 antigens using a commercial monoclonal anti-adenovirus antibody. sevent ... | 1998 | 9786518 |
| survey on viral pathogens in wild red foxes (vulpes vulpes) in germany with emphasis on parvoviruses and analysis of a dna sequence from a red fox parvovirus. | the seroprevalence of canine parvovirus (cpv), canine distemper virus (cdv), canine adenovirus (cav) and canine herpesvirus (chv) infections in red foxes (vulpes vulpes) was determined in fox sera collected between 1991 and 1995. a total of 500 sera were selected and the seroprevalences were estimated to be 13% (65 of 500 sera) for cpv, 4.4% (17 of 383 sera) for cdv, 35% (17 of 485 sera) for cav, and 0.4% (2 of 485 sera) for chv, respectively. no statistically significant differences were observ ... | 1998 | 9825797 |
| protection of dogs against canine distemper by vaccination with a canarypox virus recombinant expressing canine distemper virus fusion and hemagglutinin glycoproteins. | to evaluate the safety and efficacy of a live canarypox virus recombinant-canine distemper virus (cdv) combination vaccine against virulent cdv challenge exposure, and to document lack of interference among the other modified-live virus (mlv) components. | 1997 | 9256965 |
| a recombinant e1-deleted canine adenoviral vector capable of transduction and expression of a transgene in human-derived cells and in vivo. | human adenovirus (hav) serotypes 2 and 5 are commonly used as vector backbones for adenovirus-mediated gene transfer. however, havs were chosen as a backbone for the vectors for historical reasons and have a number of significant disadvantages when used as a shuttle for gene transfer in humans. as an initial trial to circumvent some of the shortcomings of hav vectors, we have produced an e1-deleted canine adenovirus type 2 (cav-2) vector for gene transfer. initially, we demonstrated that cav-2 u ... | 1997 | 9414258 |
| seroepidemiological survey of sympatric domestic and wild dogs (lycaon pictus) in tsumkwe district, north-eastern namibia. | disease is a potential threat to many endangered populations and may originate from sympatric domestic species. this paper describes a cross-sectional serological survey of canine pathogens carried out in domestic (n = 70) and wild dogs (lycoan pictus) (n = 6), in tsumkwe district, northeastern namibia. evidence of past exposure to canine distemper virus, canine adenovirus and parainfluenza virus was evident in both wild and domestic dogs with this, the first, documented exposure of free-living ... | 1997 | 9551484 |
| complete dna sequence of canine adenovirus type 1. | the complete dna sequence of a field strain of canine adenovirus type 1 was determined by sequencing random fragments of viral dna cloned into pbluescript. the virus has a genome of 30536 bp flanked by two identical 161 bp inverted terminal repeats. thirty orfs have been identified, based on genomic location or sequence identity with published adenoviruses. these are arranged into similar discrete regions found in the human adenoviruses. orfs in the late region show greatest identity with publis ... | 1997 | 9129661 |
| serologic survey for selected viral pathogens in brown bears from italy. | blood samples were collected from six captive bears and nine free-ranging marsican brown bears (ursus arctos marsicanus) in the abruzzo national park, italy, between 1991 and 1995. sera were tested for evidence of exposure to canine distemper virus (cdv), canine adenovirus type 2, canine coronavirus, and canine parvovirus type 2 (cpv-2). serologic evidence of cdv and cpv-2-exposure was found in both captive and free-ranging bears. this may be the first report of cdv exposure in free-ranging bear ... | 1997 | 9131563 |
| fractal analysis of lung alveoli during the acute phase vs. repair phase of an adenoviral infection in canines. | acute viral respiratory infections are commonly associated with alterations in lung growth. recently, fractal techniques have been demonstrated to show changes in alveolar perimeter after canine adenovirus type 2 (cav2) infection in a beagle puppy model. in the present study, we investigated whether the fractal dimension (df) of the alveolar perimeter was changed in the acute phase (2-3 weeks after inoculation, 131d cav2 group) or during the recovery phase (approximately 22 weeks after inoculati ... | 1997 | 9144835 |
| [sequencing of right terminal fragment of canine adenovirus type 1 vaccine strain dna]. | current studies show that adenoviruses are more advantageous as expression vectors than other viruses. canine adenovirus type 1 (cav-1) vaccine strain, cll (cannaught laboratory limited), as vectors will play more important role for the prophylaxis of zoonosis than human adenoviruses. studies on molecular biology of cav-1 or cll are necessary for construction of vectors of cll. in this paper, the right terminal of cll dna cleaved by hind ii was sequenced. authors found that it contained a 238 bp ... | 1996 | 9208578 |
| infectious canine hepatitis: detection of canine adenovirus type 1 by polymerase chain reaction. | a primer pair and a polymerase chain reaction (pcr) method earlier tested for the detection of human and animal adenoviruses were used to demonstrate the presence of canine adenovirus type 1 (cav-1) in tissue culture and clinical specimens. a simple procedure of sample preparation was elaborated making the pcr easily applicable in rapid confirmation of the diagnosis of infectious canine hepatitis. | 1996 | 8908749 |
| adenovirus protease expressed in insect cells cleaves adenovirus proteins, ovalbumin and baculovirus protease in the absence of activating peptide. | the adenovirus type 2 protease (ep) was expressed by infecting insect cells with a recombinant baculovirus. immunoblot and activity analysis showed ep to be present in both the nucleus and cytoplasm. while the insect cell expressed ep was more soluble than the escherichia coli expressed ep, its activity was one quarter of the latter, suggesting that eukaryotic postsynthetic modifications are not essential for enzyme activity. ep inactivated a cytoplasmic cathepsin-like baculovirus-encoded cystei ... | 1995 | 7483830 |
| sequence analysis of the canine adenovirus 2 fiber-encoding gene. | the gene coding for the fiber protein (fip) of canine adenovirus type 2 (cav-2) has been cloned and sequenced. the putative protein has 80% sequence similarity with the cav-1 fip. the observed differences may contribute to the known differences in cell tropism and virulence of the two types of cav. | 1995 | 7622065 |
| sequence analysis of putative pviii, e3 and fibre regions of porcine adenovirus type 3. | sequence analysis of a region of the genome of porcine adenovirus type 3 from map unit 79.5 to map unit 92 was performed. homology studies revealed genes coding for the hexon-associated protein pviii on the left and for the fibre protein on the right of the sequenced region. by analogy with the genomic organization of other adenoviruses, the 1179 bp sequence between the pviii and fibre open reading frames, extending from map unit 81.3 to map unit 84.7, was identified as the equivalent of the e3 ... | 1995 | 7625129 |
| ultrastructural study of unidentified inclusions in the cornea and iridocorneal angle of dogs with pannus. | the corneas and/or the iridocorneal angles of 13 dogs were examined morphologically by use of transmission electron microscopy. virologic identification techniques also were used for tissue from 2 dogs. four dogs had clinical signs of chronic superficial keratitis or pannus, 9 dogs had normal eyes. in the tissue from 7 dogs (4 german shepherd dogs with chronic superficial keratitis; 2 german shepherd dogs and 1 mixed-breed dog with normal eyes) we found unusual cytoplasmic inclusions. inclusions ... | 1995 | 7653888 |
| two genomic variations in the e1 region of canine adenovirus type 2 strains. | we amplified the e1 region of canine adenovirus type 2 genomes by the polymerase chain reaction (pcr) and analyzed the pcr products by using eight restriction endonucleases. restriction patterns of the e1 region cleaved with haeiii and rsai revealed two genomic variations among the canine adenovirus type 2 strains. although the clinical significance of two distinct genotypes among the canine adenovirus type 2 strains is currently unknown, these genomic variations are well conserved among differe ... | 1994 | 7941300 |
| serologic survey of giant pandas (ailuropoda melanoleuca), and domestic dogs and cats in the wolong reserve, china. | sera from captive and recently rescued giant pandas (ailuropoda melanoleuca) in the wolong reserve, china, were examined by serum neutralization or hemagglutination inhibition for antibodies to canine distemper virus (cdv), canine coronavirus (ccv), canine herpesvirus (chv), pseudorabies virus (prv), canine adenovirus type 2 (cav), and canine parvovirus (cpv). serum samples from village domestic dogs and cats, which run free throughout the reserve also were examined. antibodies against cpv were ... | 1994 | 8151830 |
| dual infection with canine distemper virus and infectious canine hepatitis virus (canine adenovirus type 1) in a dog. | a 72-day-old, female, golden retriever dog showed anorexia, coughing, nasal discharge, diarrhea and hematochezia, and died on the 15th clinical day. pathological examination revealed dual infection with canine distemper virus (cdv) and canine adenovirus (cav). cav inclusion bodies occurred only in the liver, and biliary and respiratory system, whereas cdv inclusions were demonstrated in the visceral organs systematically. the cav inclusions were associated with multifocal hepatocellular necrosis ... | 1993 | 8399762 |
| fractal and morphometric analysis of lung structures after canine adenovirus-induced bronchiolitis in beagle puppies. | acute viral respiratory infections are commonly associated with alteration in lung growth and with chronic obstructive disease. however, it is difficult to quantify these changes in lung function. we determined that the recently described techniques of fractal analysis gave additional information about the changes in lung function after viral illness compared to standard morphometric techniques. fractal and morphometric parameters change with lung growth after acute infection with canine adenovi ... | 1993 | 8414744 |
| primary structure of the canine adenovirus pvii protein: functional implications. | the dna sequence of an open reading frame (orf) corresponding to the canine adenovirus type 1 (can 1, utrecht strain) pro-vii (pvii) protein gene was determined. 560 base pairs were sequenced from the upstream end of the hindiii-a genomic fragment. the sequence gives the 33 c-terminal residues of the penton base protein followed by the 132 residue pvii protein, thus conforming to the same order and location of these genes as in ad2. the authenticity of this putative pvii-orf was confirmed by n-t ... | 1993 | 8460501 |
| hemagglutination properties and nucleotide sequence analysis of the fiber gene of adenovirus genome types 11p and 11a. | the fiber has been suggested to serve as the ligand between the adenovirus capsid and the host cell receptor. the two genome types, ad11p and ad11a, of adenovirus serotype 11 display different tropisms. the fiber amino acid sequences of the two genome types have been deduced from the 975 nucleotides that encoded a fiber polypeptide of 35,500 da. the fiber consists of a tail, a shaft, and a knob region. the amino acids 44 to 140 form a typical shaft domain of six 15-residue repetitive motifs. ten ... | 1993 | 8503168 |
| multiple enlargements in the right inverted terminal repeat of the dna of canine adenovirus type 2. | the manhattan strain of canine adenovirus type 2 (cav 2) was examined. restriction endonuclease analysis and blot hybridization experiments revealed the heterogeneity of the viral dna. at least 9 unequally expanded species of the viral genome have been recognized. this diversity is caused by different enlargements in the right inverted terminal repeat (itr) of the virus. the differences between the individual enlargements were shown to be the different multiples of 150 base pairs. relatedness of ... | 1992 | 1307439 |
| a serologic survey of the island fox (urocyon littoralis) on the channel islands, california. | the island fox is listed as a threatened species in california. a serologic survey of 194 island foxes (urocyon littoralis) was conducted over the entire range of the species on the channel islands (california, usa). antibody prevalence against canine adenovirus and canine parvovirus reached 97% and 59%, respectively, in some populations sampled. antibody prevalence of canine herpesvirus, canine coronavirus, leptospirosis and toxoplasmosis were low. antibodies against canine distemper virus were ... | 1992 | 1318424 |