Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| complete and incomplete hepatitis b virus particles: formation, function, and application. | hepatitis b virus (hbv) is a para-retrovirus or retroid virus that contains a double-stranded dna genome and replicates this dna via reverse transcription of a rna pregenome. viral reverse transcription takes place within a capsid upon packaging of the rna and the viral reverse transcriptase. a major characteristic of hbv replication is the selection of capsids containing the double-stranded dna, but not those containing the rna or the single-stranded dna replication intermediate, for envelopmen ... | 2017 | 28335554 |
| extracellular vesicles deliver host and virus rna and regulate innate immune response. | the innate immune system plays a crucial role in controlling viral infection. pattern recognition receptors (prrs), such as toll-like receptors and rig-i-like receptors, sense viral components called pathogen-associated molecular patterns (pamps) and trigger signals to induce innate immune responses. extracellular vesicles (evs), including exosomes and microvesicles, deliver functional rna and mediate intercellular communications. recent studies have revealed that evs released from virus-infecte ... | 2017 | 28335522 |
| erbb4 acts as a suppressor in the development of hepatocellular carcinoma. | erbb4, one member of the epidermal growth factor receptor (egfr) family, plays a key role in physiological and pathological processes. recently, we identified that erbb4 played a protective role from chronic hepatitis b virus infection. however, the role of erbb4 in hepatocellular carcinoma (hcc) is still unclear. here, we explore the role of erbb4 in the development of hcc using in vitro models, in vivo animal models and clinical samples of hcc. liver-specific erbb4 knockout alleles and full er ... | 2017 | 28334319 |
| the incidence of low seroimmunity to hepatitis b virus in children with inflammatory bowel disease. | patients with inflammatory bowel disease (ibd) often receive immunosuppressive therapy which may make them vulnerable to infections such as hepatitis b. we hypothesized that hepatitis b virus (hbv) titers are low in the vaccinated pediatric ibd population. the aims of our study were to identify the incidence of lower titers of hepatitis b surface antibody (hbsab) and determine which patient factors may be associated with lower hbsab titers. | 2017 | 28333769 |
| occult hbv among anti-hbc alone: mutation analysis of an hbv surface gene and pre-s gene. | the aim of this study is to investigate the molecular characteristics of occult hepatitis b virus (hbv) infection in 'anti-hbc alone' subjects. | 2017 | 28332361 |
| entecavir to telbivudine switch therapy in entecavir-treated patients with undetectable hepatitis b viral dna. | this study examined 2-year outcome of consecutive therapy using entecavir (etv) followed by telbivudine (ldt) in subjects with undetectable hepatitis b virus (hbv) dna level and normal alanine aminotransferase level after the initial 6 months of etv treatment. | 2017 | 28332360 |
| the mitochondrial hinge protein, uqcrh, is a novel prognostic factor for hepatocellular carcinoma. | alterations in mitochondrial respiration contribute to the development and progression of cancer via abnormal biogenesis, including generation of reactive oxygen species. ubiquinol-cytochrome c reductase hinge protein (uqcrh) consists of the cytochrome bc1 complex serving respiration in mitochondria. in the present study, we analyzed uqcrh abnormalities in hepatocellular carcinoma (hcc) and its association with clinical outcomes of patients. uqcrh expression in hcc was determined via semiquantit ... | 2017 | 28332314 |
| transmission of hepatitis d virus between spouses: a longitudinal study of the first reported canadian case. | in chronic hepatitis b (chb), hepatitis d virus (hdv) superinfection can lead to acute liver failure. the incidence of hdv superinfection is unknown, but is often detected in immigrants from hdv endemic countries. in this report, we characterize long-term clinical and virological outcomes in a hepatitis b virus (hbv) infected carrier before and after hdv superinfection, acquired from their spouse having hbv/hdv co-infection. a 38 year-old mongolian male with chb on anti-hbv therapy developed acu ... | 2017 | 28331807 |
| natural killer cell activation contributes to hepatitis b viral control in a mouse model. | the roles of cd4 + t cells and cd8 + t cells in hepatitis b virus (hbv) infection have been well documented. however, the role of innate immunity in hbv infection remains obscure. here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (polyi:c) on hbv infection. a chronic hbv replication mouse model was established by hydrodynamical injection of paav/hbv1.2 plasmid into c57bl/6 mice. we found that hbv did not seem to induce an active nk-cell response in ... | 2017 | 28331190 |
| dynamic and specific immune responses against multiple tumor antigens were elicited in patients with hepatocellular carcinoma after cell-based immunotherapy. | hepatocellular carcinoma (hcc) is one of the most common cancers in china and frequently occurs with chronic hepatitis b virus infection. to investigate whether cell-based cancer immunotherapy induces tumor specific immune responses in patients with hcc and provides clinical benefits, as well as to elucidate the most immunogenic tumor associated antigens (taas), multiple antigen stimulating cellular therapy (masct) was applied in addition to standard of care. | 2017 | 28330473 |
| off-treatment hepatitis b virus (hbv) dna levels and the prediction of relapse after discontinuation of nucleos(t)ide analogue therapy in patients with chronic hepatitis b: a prospective stop study. | the optimal management remains unknown after nucleos(t)ide analogue (na) discontinuation in patients with chronic hepatitis b (chb). this prospective study investigated the role of off-treatment viral kinetics in predicting relapse after discontinuation of na therapy. | 2017 | 28329347 |
| association of mutations in tlr2 signaling genes with fulminant form of hepatitis b related acute liver failure. | fulminant form of hepatitis b related acute liver failure (fhb-alf) is a rare but highly fatal outcome of acute hepatitis b virus (hbv) infection. its related host factors have not been studied. | 2017 | 28329297 |
| pegylated interferon alfa-2b add-on treatment in hepatitis b virus envelope antigen-positive chronic hepatitis b patients treated with nucleos(t)ide analogue: a randomized, controlled trial (pegon). | we studied whether 48 weeks of pegylated interferon alfa-2b (peginterferon) add-on therapy increases serological response in hepatitis b virus (hbv) envelope antigen (hbeag)-positive patients receiving nucleos(t)ide analogue (na) therapy, compared with continued na monotherapy. | 2017 | 28329061 |
| frequency and role of nkp46 and nkg2a in hepatitis b virus infection. | natural killer (nk) cells are involved in the control of viral infection. however, the role of nk cells in chronic hepatitis b (chb) remains unclear. this study investigated the frequencies and roles of nk cells in chb, with a focus on activating receptor nkp46 and inhibitory receptor nkg2a. | 2017 | 28328926 |
| evaluation of apri and fib-4 for noninvasive assessment of significant fibrosis and cirrhosis in hbeag-negative chb patients with alt ≤ 2 uln: a retrospective cohort study. | to evaluate the performance of aspartate transaminase-to-platelet ratio index (apri) and fibrosis index based on four factors (fib-4) to predict significant fibrosis and cirrhosis in hepatitis b virus e antigen (hbeag)-negative chronic hepatitis b (chb) patients with alanine transaminase (alt) ≤ twice the upper limit of normal (2 uln).histologic and laboratory data of 236 hbeag-negative chb patients with alt ≤ 2 uln were analyzed. predicted fibrosis stage, based on established scales and cut-off ... | 2017 | 28328813 |
| infectious diseases prevalence, vaccination coverage, and diagnostic challenges in a population of internationally adopted children referred to a tertiary care children's hospital from 2009 to 2015. | infectious diseases are common in internationally adopted children (iac).with the objective to evaluate infectious diseases prevalence in a large cohort of iac and to explore possible risk factors for tuberculosis (tb) and parasitic infections, clinical and laboratory data at first screening visit of all iac (<18 years) consecutively referred to our center in 2009 to 2015 were collected and analyzed.in total, 1612 children (median age: 5.40 years; interquartile range: 3.00-7.90) were enrolled, 1 ... | 2017 | 28328809 |
| influence of polymorphisms in the wnt/β-catenin pathway genes on hepatocellular carcinoma risk in a chinese han population. | the wnt/β-catenin pathway plays a vital role in initiating and sustaining hepatocellular carcinoma (hcc). however, few studies have investigated polymorphisms in the wnt/β-catenin signaling pathway genes in the chinese han population. the aim of the present retrospective study was to investigate the correlations between polymorphisms of the wnt/β-catenin signaling pathway genes (ctnnb1 and wnt2) and hcc susceptibility, development, and progression.twenty tagging single nucleotide polymorphisms w ... | 2017 | 28328801 |
| predictive model for inflammation grades of chronic hepatitis b: large-scale analysis of clinical parameters and gene expressions. | liver biopsy is the gold standard to assess pathological features (e.g. inflammation grades) for hepatitis b virus infected patients, although it's invasive and traumatic; meanwhile, several gene profiles of chronic hepatitis b (chb) have been separately described in relatively small hbv-infected samples. we aimed to analyze correlations among inflammation grades, gene expressions and clinical parameters (serum alanine amino transaminase, aspartate amino transaminase, and hbv-dna) in large-scale ... | 2017 | 28328162 |
| clinical features and viral quasispecies characteristics associated with infection by the hepatitis b virus g145r immune escape mutant. | coexistence of the hepatitis b surface antigen (hbsag) and hepatitis b surface antibody (anti-hbs) is an uncommon phenomenon, and the underlying mechanisms remain largely unknown. amino-acid (aa) substitution from glycine to arginine at aa 145 (g145r), in the major hydrophilic region, has been reported in patients with hbsag and anti-hbs coexistence. however, there is limited knowledge about the clinical features and viral quasispecies characteristics associated with g145r mutant hepatitis b vir ... | 2017 | 28325923 |
| "waiting for daas": a retrospective chart review of patients with untreated hepatitis c in rwanda. | access to treatment for hepatitis c virus (hcv) in sub-saharan africa is extremely limited. with the advent of direct acting antivirals (daas), highly effective and easy-to-deliver oral regimens are now available on the global market. this study was conducted to understand the background and characteristics of a national cohort of patients with hcv infection enrolled in care and awaiting therapy with daas. | 2017 | 28323868 |
| serum aminotransferase flares in pregnant and postpartum women with current or prior treatment for chronic hepatitis b. | antiviral therapy is recommended for pregnant women with chronic hepatitis b (chb) and hepatitis b virus (hbv) dna>200,000 iu/ml, but there is less consensus on management of women who discontinue therapy in anticipation of pregnancy or who become pregnant while on therapy. the goal of this study was to describe flares in alanine aminotransferase (alt) during pregnancy and postpartum in chb women with current and/or prior treatment. | 2017 | 28323748 |
| update on viral hepatitis in pregnancy. | pregnant women with acute viral hepatitis are at higher risk of morbidity and death than pregnant women with chronic viral hepatitis. the risk of death is highest with acute viral hepatitis e, and the rate of transmission to the baby may be highest with hepatitis b virus (hbv) infection. managing viral hepatitis in pregnancy requires assessing the risk of transmission to the baby, determining the gestational age at the time of infection and the mother's risk of decompensation, and understanding ... | 2017 | 28322675 |
| nanofluidic devices with 8 pores in series for real-time, resistive-pulse analysis of hepatitis b virus capsid assembly. | to improve the precision of resistive-pulse measurements, we have used a focused ion beam instrument to mill nanofluidic devices with 2, 4, and 8 pores in series and compared their performance. the in-plane design facilitates the fabrication of multiple pores in series, which, in turn, permits averaging of the series of pulses generated from each translocation event. the standard deviations (σ) of the pulse amplitude distributions decrease by 2.7-fold when the average amplitudes of eight pulses ... | 2017 | 28322548 |
| declining antibody levels after hepatitis b vaccination in down syndrome: a need for booster vaccination? | we determined the anti-hbs titer in 227 children of all ages with down syndrome (ds). only 48.1% (95% ci: 35.1-61.3) of the ds children aged 7-10 years and 31.9% (95% ci: 22.1-43.6) of the ds children aged >10 years had a protective anti-hbs titer (≥10 iu/l). the geometric mean anti-hbs titer was significantly lower in the ds children; this suggests booster vaccination for hbv may be needed. this article is protected by copyright. all rights reserved. | 2017 | 28322457 |
| reduction of acute hepatitis b through vaccina-tion of adolescents with no decrease in chronic hepatitis b due to immigration in a low ende-micity country. | with a hepatitis b prevalence of 0.3%, switzerland is a country with low endemicity. unlike most other countries, switzerland's recommendation for vaccination against hepatitis b has since 1998 focused on adolescents aged 11 to 15 years rather than on infants, in addition to risk groups since 1982. this paper describes the evolution of the incidence of acute hepatitis b virus (hbv) infection and newly reported chronic cases in switzerland, as well as their epidemiological features, in order to d ... | 2017 | 28322417 |
| pharmacological interventions for acute hepatitis b infection: an attempted network meta-analysis. | infection with hepatitis b virus (hbv) can be symptomatic or asymptomatic. apart from chronic hbv infection, the complications related to acute hbv infection are severe acute viral hepatitis and fulminant hepatitis characterised by liver failure. the optimal pharmacological treatment of acute hbv infection remains controversial. | 2017 | 28321877 |
| adjusted particle size eliminates the need of linkage of antigen and adjuvants for appropriated t cell responses in virus-like particle-based vaccines. | since the discovery of the first virus-like particle (vlp) derived from hepatitis b virus in 1980 (1), the field has expanded substantially. besides successful use of vlps as safe autologous virus-targeting vaccines, the powerful immunogenicity of vlps has been also harnessed to generate immune response against heterologous and even self-antigens (2-4). linking adjuvants to vlps displaying heterologous antigen ensures simultaneous delivery of all vaccine components to the same antigen-presenting ... | 2017 | 28321220 |
| diabetes mellitus, insulin resistance and hepatitis c virus infection: a contemporary review. | to summarise the literature data on hepatitis c virus (hcv)-infected patients concerning the prevalence of glucose abnormalities and associated risk. | 2017 | 28321170 |
| association between tlr7 copy number variations and hepatitis b virus infection outcome in chinese. | to explore whether copy number variations (cnvs) of toll-like receptor 7 (tlr7) are associated with susceptibility to chronic hepatitis b virus (hbv) infection. | 2017 | 28321161 |
| different mechanisms may exist for hbsag synthesis and secretion during various phases of chronic hepatitis b virus infection. | background the aim of this study was to characterize the expression and secretion of hepatitis b surface-antigen (hbsag) in the hepatocytes of hepatitis b virus (hbv)-infected patients at different phases of infection; as such, the association of intrahepatic hbsag expression with virological markers and the histological characteristics were analyzed. material and methods 302 chronic hbv infection patients who had not received antiviral therapy were stratified by hbeag status. the proportion of ... | 2017 | 28321112 |
| 3-hydroxypyrimidine-2,4-diones as novel hepatitis b virus antivirals targeting the viral ribonuclease h. | hepatitis b virus (hbv) ribonuclease h (rnh) is an appealing therapeutic target due to its essential role in viral replication. rnh inhibitors (rnhis) could help more effectively control hbv infections. here, we report 3-hydroxypyrimidine-2,4-diones as novel hbv rnhis with antiviral activity. we synthesized and tested 52 analogs and found 4 that inhibit hbv rnh activity in infected cells. importantly, 2 of these compounds inhibited hbv replication in the low micromolar range. | 2017 | 28320718 |
| the practice pattern of hepatitis b testing in rheumatoid arthritis patients: a cross-national comparison between us and taiwan. | the hepatitis b virus (hbv) testing rates and patterns in rheumatoid arthritis (ra) patients starting disease modifying anti-rheumatic drugs (dmards) have not been well studied. we describe and compare the practice patterns of hbv testing among ra patients in u.s. and taiwan. | 2017 | 28320050 |
| hepatocyte nuclear factor 1α downregulates hbv gene expression and replication by activating the nf-κb signaling pathway. | the role of hepatocyte nuclear factor 1α (hnf1α) in the regulation of gene expression and replication of hepatitis b virus (hbv) is not fully understood. previous reports have documented the induction of the expression of viral large surface protein (lhbs) by hnf1α through activating viral sp1 promoter. large amount of lhbs can block the secretion of hepatitis b surface antigen (hbsag). here we found that hnf1α overexpression inhibited hbv gene expression and replication in huh7 cells, resulting ... | 2017 | 28319127 |
| bone marrow-derived mesenchymal stem cells attenuate immune-mediated liver injury and compromise virus control during acute hepatitis b virus infection in mice. | mesenchymal stem cells (mscs) have been used as therapeutic tools not only for their ability to differentiate toward different cells, but also for their unique immunomodulatory properties. however, it is still unknown how mscs may affect immunity during hepatitis b virus (hbv) infection. this study was designed to explore the effect of bone marrow-derived mscs (bm-mscs) on hepatic natural killer (nk) cells in a mouse model of acute hbv infection. mice were injected with 1 × 10(6) bm-mscs, which ... | 2017 | 28318408 |
| high rate of hepatitis b virus infection among hairdressers in ibadan, nigeria. | hepatitis b virus (hbv) infection is a major public health problem for over two billion people infected globally. occupationally exposed persons are at high risk of hbv infection and, apart from medical personnel, there is dearth of information concerning the prevalence and awareness of hbv among this population in nigeria. this study was designed to determine the levels of hbv awareness and prevalence of hbv infection among hairdressers in ibadan, nigeria. hairdressers and teachers (unmatched c ... | 2017 | 28318369 |
| statins decrease the risk of decompensation in hbv- and hcv-related cirrhosis: a population-based study. | statin decreased the risk of decompensation and mortality in veteran patients with cirrhosis due to hepatitis c virus (hcv). whether this beneficial effect can be extended to cirrhosis in general population or cirrhosis with other causes, such as hepatitis b virus (hbv) infection and alcohol, remains unknown. statin also decreased the risk of hepatocellular carcinoma (hcc) in patients with chronic hbv and hcv infection. it is unclear whether the effect can be observed in patients already with ci ... | 2017 | 28318053 |
| nucleos(t)ide analogues for preventing hbv reactivation in immunosuppressed patients with hematological malignancies: a network meta-analysis. | we aimed to evaluate the efficacy of five oral nucleos(t)ide analogues (nas), including lamivudine, entecavir, adefovir, telbivudine and tenofovir, for the prevention of hepatitis b virus (hbv) reactivation and hbv-related complications in chronic hepatitis b virus (chb) infected patients with hematological malignancies receiving chemotherapy or hematopoietic stem cell transplantation (hsct) by network meta-analysis. | 2017 | 28317397 |
| hepatitis b virus and human t-cell lymphotropic virus type 1 co-infection in the northern territory, australia. | to establish the relationship between hepatitis b virus (hbv) and human t-cell lymphotropic virus type 1 (htlv-1) serological markers in the northern territory, australia. | 2017 | 28315754 |
| stimulation of inducible nitric oxide by hepatitis b virus transactivator protein-hbx requires mta1 coregulator. | 2017 | 28314778 | |
| on-treatment hbv dna level could predict hbeag seroclearance in patients with hbeag-positive chronic hepatitis b with entecavir therapy. | hepatitis b e antigen (hbeag) status is associated with clinical outcomes, and seroconversion of hbeag is one of the treatment goals. in this study, we determined the association of on-treatment serum hepatitis b virus (hbv) dna levels in hbeag-positive chronic hepatitis b patients who were receiving entecavir (etv) treatment. | 2017 | 28314596 |
| diagnosis of viral hepatitis. | chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infections and hiv-hbv and hcv coinfection are major causes of chronic liver disease worldwide. testing and diagnosis is the gateway for access to both treatment and prevention services, but there remains a large burden of undiagnosed infection globally. we review the global epidemiology, key challenges in the current hepatitis testing response, new tools to support the hepatitis global response (2016-2020 global hepatitis health sector ... | 2017 | 28306597 |
| therapeutic plasma exchange versus double plasma molecular absorption system in hepatitis b virus-infected acute-on-chronic liver failure treated by entercavir: a prospective study. | therapeutic plasma exchange (tpe) and double plasma molecular absorption system (dpmas) were two extracorporeal liver support systems. few studies compared their efficacy profile. | 2017 | 28304106 |
| silent killers: transfusion transmissible infections-tti, among asymptomatic population of pakistan. | to analyse transfusion transmissible infections in asymptomatic population. | 2017 | 28303984 |
| sb 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant hcv variants. | sb 9200 is a novel, first-in-class oral modulator of innate immunity that is believed to act via the activation of the rig-i and nod2 pathways. sb 9200 has broad-spectrum antiviral activity against rna viruses including hepatitis c virus (hcv), norovirus, respiratory syncytial virus and influenza and has demonstrated activity against hepatitis b virus (hbv) in vitro and in vivo. in phase i clinical trials in chronically infected hcv patients, sb 9200 has been shown to reduce hcv rna by up to 1.9 ... | 2017 | 28303593 |
| seroepidemiology of hepatitis a, hepatitis b and varicella virus in people living with hiv in ireland. | epidemiological studies investigating seroprevalence of vaccine preventable infections at both individual and population level are important in guiding screening and vaccination practices. data on seroprevalence of common vaccine preventable infections in hiv-infected individuals is lacking. we carried out a retrospective cohort study to investigate serological immunity and factors associated with immunity to hepatitis a virus (hav), hepatitis b virus (hbv) and varicalla virus (vzv) in a cohort ... | 2017 | 28302512 |
| active immunization against transforming growth factor-beta1 prevents hepatic fibrosis in a rat model of liver disease. | transforming growth factor-beta1 (tgf-β1) plays an important role in hepatic fibrogenesis. to document the effects of active immunization against tgf-β1 on hepatic fibrosis in an animal model of chronic liver disease. balb/c mice were immunized against three different peptides of tgf-β1 ligated into hepatitis b virus core protein (hbvc). titers of tgf-β1 antibodies were documented by enzyme linked immunoassays and antibody activity by cell membrane receptor binding and proliferation assays. the ... | 2017 | 28301738 |
| association between the telomerase rs2736098_tt genotype and a lower risk of chronic hepatitis b and cirrhosis in chinese males. | chronic hepatitis b (chb) is caused by infection of hepatitis b virus (hbv) and liver cirrhosis (lc) is its most common complication. the accumulated evidence indicates a genetic context of hbv infection phenotypes. here we determine a potential association of chb/lc with the genetic variant of telomerase reverse transcriptase (tert), a key player in aging including immune-senescence. | 2017 | 28300824 |
| the enrichment of hbv immune-escape mutations during nucleoside/nucleotide analogue therapy. | drug-resistant hbv mutants frequently arise during nucleos(t)ide analogues (nas) therapy, while the resistance mutations on polymerase also have consequent changes in the s protein. besides, the enrichment of immune-escape mutations was negatively correlated with hbsag clearance under nas therapy. this study aims to characterize the variability of hepatitis b virus polymerase and surface antigen in patients with virologic breakthrough under nucleos(t)ide analogues therapy. | 2017 | 28300730 |
| complete genome sequence of a hepatitis b virus isolate of genotype d2, subtype adrq+, from brazil. | hepatitis b virus (hbv) has been classified into 10 distinct serological subtypes of the surface antigen (hbsag) that can be predicted by sequencing of the corresponding s gene. hbv genotype d usually displays determinants of subtypes ayw2 or ayw3. on the other hand, subtype adrq+ has been found exclusively in association with genotype c. here, we describe the first hbv genome (isolate br32) belonging to genotype d with the serological subtype adrq+. this isolate had a genome length of 3,062 nuc ... | 2017 | 28181035 |
| correlation between hepatitis b surface antigen titers and hbv dna levels. | to assess the correlation between serum hbsag titers and hepatitis b virus (hbv) dna levels in patients with hepatitis b envelop antigen-negative (hbeag -ve) hbv genotype-d (hbv/d) infection. | 2017 | 24195978 |
| hepatitis b virus sequencing and liver fibrosis evaluation in hiv/hbv co-infected nigerians. | molecular characteristics of hepatitis b virus (hbv), such as genotype and genomic mutations, may contribute to liver-related morbidity and mortality. the association of these characteristics with liver fibrosis severity in sub-saharan africa is uncertain. we aimed to characterize molecular hbv features in hiv/hbv co-infected nigerians and evaluate associations between these characteristics and liver fibrosis severity before and after antiretroviral therapy (art) initiation. | 2017 | 28376292 |
| permissive, in vitro replication of hepatitis b virus genotype e. | a cloned stable cell line, hepg2-hbve6, was established following transfection of hepg2 cells with a retroviral plasmid into which a 1.1-fold genomic construct of hepatitis b virus (hbv) belonging to genotype e (hbv/e) was inserted. the cell line retains the entire hbv/e insert, and produces episomal hbv dna. it expresses hbv pregenomic, pres1 and pres2/s transcripts, and sheds hepatitis b surface and e antigens as well as structures resembling hbv-subviral and dane particles. the hepg2-hbve6 ce ... | 2017 | 28122202 |
| origin and evolutionary dynamics of hepatitis b virus (hbv) genotype e in madagascar. | africa is one of the endemic regions of hbv infection. in particular, genotype e is highly endemic in most of sub-saharan africa such as west african countries where it represents more than 90% of total infections. madagascar, which is classified as a high endemic area for hbv and where the most prevalent genotype is e, might play a relevant role in the dispersion of this genotype due to its crucial position in the indian ocean. the aim of this study was to investigate the origin, population dyn ... | 2017 | 28081689 |
| first epidemiological and phylogenetic analysis of hepatitis b virus infection in migrants from mali. | the armed conflict in mali caused a migration crisis since 2012. most malian refugees were in italy. in sub-saharan africa, the seroprevalence of anti-hbv antibodies is particularly high. genotype e is the most prevalent throughout a crescent covering area from angola to senegal, including mali. we report 16 hbv positive individual from 136 malian asylum seekers in order to investigate the genetic diversity of hbv in this population. sequencing and phylogenetic analysis has been used. the hbv ge ... | 2017 | 27576107 |
| nitrative and oxidative dna damage in infection-related carcinogenesis in relation to cancer stem cells. | infection and chronic inflammation have been recognized as important factors for carcinogenesis. under inflammatory conditions, reactive oxygen species (ros) and reactive nitrogen species (rns) are generated from inflammatory and epithelial cells, and result in the formation of oxidative and nitrative dna lesions, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodg) and 8-nitroguanine. the dna damage can cause mutations and has been implicated in inflammation-mediated carcinogenesis. it has bee ... | 2017 | 28163802 |
| evaluation of helicobacter pylori infection in patients with chronic hepatic disease. | the 13c urea breath test (13c-ubt) is the gold standard for detecting helicobacter pylori infection. h. pylori pathogenesis in patients with hepatitis b virus (hbv) and related diseases remains obscure. we used 13c-ubt to detect h. pylori infection in patients with chronic hbv infection, hbv-related cirrhosis, hbv-related hepatic carcinoma, and other chronic hepatic diseases. | 2017 | 28091405 |
| [the potential use of serum hbv rna to guide the functional cure of chronic hepatitis b]. | hepatitis b virus (hbv) covalently closed circular dna (cccdna) in infected hepatocytes is the main cause of off-therapy viral rebound. the half-life of cccdna is only 33-50 days, so the conversion of newly synthesized rcdna to cccdna in the nucleus is essential for the maintenance of cccdna pool in infected hepatocytes. though not directly targeting the existing cccdna, current nucleos(t)ide analogues (nas) may exhaust the cccdna reservoir by blocking the rcdna formation. indeed, a prolonged co ... | 2017 | 28297795 |
| [research advances in diagnosis and treatment of liver failure in 2016]. | liver failure has various clinical types, a complex pathogenesis, and rapid disease progression, as well as a high mortality rate. liver failure caused by hepatitis b virus infection is the most common type in china with severe conditions, various complications, and a mortality rate as high as 40%-90%. invasive fungal disease secondary to acute-on-chronic liver failure can affect patients' prognosis and increase mortality rate. this article introduces the research advances in hepatitis b-related ... | 2017 | 28297793 |
| [advances in clinical research on rta181 mutation in hepatitis b virus]. | nowadays, nucleos(t)ide analogues (nas) are important drugs for the treatment of chronic hepatitis b and can suppress the virus through inhibiting the activity of hepatitis b virus (hbv) polymerase. however, rta181 mutation in hbv can reduce the sensitivity of hbv to various nas, which brings new challenges to antiviral therapy. this article briefly introduces the research advances in the clinical detection rate of rta181 mutation and its influence on therapeutic effect and prognosis. | 2017 | 28297788 |
| [risk factors for hospital-acquired infection in patients with liver cirrhosis and value of immuknow assay in monitoring immune cell function]. | 2017 | 28297778 | |
| genetic variation in the vitamin d pathway cyp2r1 gene predicts sustained hbeag seroconversion in chronic hepatitis b patients treated with pegylated interferon: a multicenter study. | evidence of a role of vitamin d in the immune system is increasing. low serum vitamin d is associated with increased hepatitis b virus replication. genome-wide association study (gwas) data has revealed a number of the single nucleotide polymorphisms (snps) within the vitamin d synthetic pathway that affect vitamin d functions. we aimed to determine the association between snps in the vitamin d gene cascade and response to pegylated interferon (pegifn) therapy in hepatitis b e-antigen (hbeag)-po ... | 2017 | 28296915 |
| ugt1a1*28 relationship with abnormal total bilirubin levels in chronic hepatitis c patients: outcomes from a case-control study. | gilbert syndrome (gs) is a frequent benign clinical condition, marked by intermittent unconjugated hyperbilirubinemia, mostly due to the polymorphism uridine diphosphate-glucuronosyltransferase 1a1*28 (ugt1a1*28). hyperbilirubinemia has been reported in a gs patient undergoing hepatitis c treatment, and other ugt isoforms polymorphisms have been linked to worse outcomes in viral hepatitis. yet, little is known to gs contributions' to the liver disease scenario. our aim was to assess ugt1a1 genot ... | 2017 | 28296739 |
| severity and outcome of acute-on-chronic liver failure is dependent on the etiology of acute hepatic insults: analysis of 368 patients. | acute-on-chronic liver failure (aclf) may be precipitated by various hepatic insults. the present study evaluated the outcomes of aclf with different acute insults. | 2017 | 28296656 |
| the full length genomic sequence of a novel hla-a*24 allele, hla-a*24:353, identified in a patient with hepatitis b infection. | hla-a*24:353 differs from hla-a*24:02:01 by an amino acid exchange glutamine to glutamate at position 316. | 2017 | 28296275 |
| long term outcome of inactive and active, low viremic hbeag negative hepatitis b virus infection: benign course towards hbsag clearance. | the difference between the long-term outcome of low-viremic (hbv-dna≤20,000-iu/ml, lv-ac) and inactive hbsag carriers (hbv-dna≤2,000-iu/ml, ic) remains to be defined. we studied prospectively 153 hbeag-negative hbsag-carriers with baseline hbv-dna≤20,000-iu/ml and normal transaminases. | 2017 | 28296013 |
| low hepatitis b virus-specific t-cell response in males correlates with high regulatory t-cell numbers in murine models. | hepatitis b virus (hbv) infection shows significant gender-related differences in pathogenesis, disease progression, and development of hepatocellular carcinoma. the gender-associated differences in hbv replication and viral protein levels may be associated with distinct hbv-specific immune responses in the host. in the present study, we examined the impact of gender on hbv-specific immune responses in two different mouse models representing transient and persistent hepadnaviral infection; hydro ... | 2017 | 28295453 |
| elimination of hepatitis b: is it a mission possible? | chronic hepatitis b virus (hbv) infection is a global public health issue. although the disease cannot be cured effectively, disease management has been improved over the past decade. the introduction of potent nucleos(t)ide analogues (nas) to suppress viral replication represented a giant leap in the control of this disease. it has been shown that tenofovir treatment, a potent na, complements current immunoprophylaxis to diminish mother-to-infant transmission in pregnant women with a high viral ... | 2017 | 28292309 |
| a preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis c virus infection in hunan, china. | european researchers have underscored associations between single nucleotide polymorphism (snp) rs2287622 of the hepatobiliary bile salt export pump (bsep) gene and the risk of hepatitis c virus (hcv) infection. the distributions of snp rs2287622 are racially specific. this study was aimed to preliminarily investigate the distribution of bsep gene snp rs2287622 in the han patients with chronic hcv-infection (chc) in hunan, china. | 2017 | 28292275 |
| transmission of hbv dna mediated by ceramide-triggered extracellular vesicles. | an extracellular vesicle (ev) is a nanovesicle that shuttles proteins, nucleic acids, and lipids, thereby influencing cell behavior. a recent crop of reports have shown that evs are involved in infectious biology, influencing host immunity and playing a role in the viral life cycle. in the present work, we investigated the ev-mediated transmission of hepatitis b virus (hbv) infection. | 2017 | 28275693 |
| advancing the regulatory path on hepatitis b virus treatment and curative research: a stakeholders consultation. | hepatitis b infection remains a significant disease burden around the world, with an estimated two billion individuals infected and 350 million living with chronic hepatitis b. current antivirals are efficacious, but require lifelong treatment for the majority of infected individuals. the field is galvanised to improve diagnostics and treatment with the goal to develop shorter, finite treatments leading to viral control after treatment discontinuation. achievement of complete and functional cure ... | 2017 | 28275452 |
| [exogenous hbx promotes epithelial-mesenchymal transition of hepatic progenitor cells in kunming mice]. | objective to construct an animal model in which hepatitis b virus x protein (hbx) directly affect hepatic progenitor cells (hpcs), and investigate the potential mechanisms underlying epithelial-mesenchymal transition (emt) of hpcs. methods kunming mice were given 2 ml/l carbon tetrachloride (ccl4) in oil solution by gavage twice a week. four weeks later, hpcs transfected with recombinant lentiviral vectors stably expressing hbx gene as well as empty vectors were separately injected into the mice ... | 2017 | 28274311 |
| [recombinant hbcag promotes secretion of il-15 in myeloid dendritic cells via p38mapk signaling pathway]. | objective to study the mechanism by which recombinant human hepatitis b virus core antigen (rhhbcag) induces interleukin-15 (il-15) secretion in myeloid dendritic cells (mdcs). methods human peripheral blood monocytes were isolated from peripheral blood of healthy volunteers by dynabeads untouched human monocytes kit. we obtained mdcs by culturing the monocytes in the presence of gm-csf, il-4 and tnf-α. in one group, mdcs were cultured in rpmi1640 and stimulated by rhhbcag at the final concentra ... | 2017 | 28274303 |
| effect of 48-week pegylated interferon α-2a or nucleos(t)ide analogue therapy on renal function in chinese patients with chronic hepatitis b. | controversy remains as to whether antiviral agents contribute to renal dysfunction in patients with chronic hepatitis b virus (hbv) infection. thus, the aim of study was to analyze the changes in renal function of chronic hepatitis b (chb) patients in response to anti-hbv therapy and the association with treatments. | 2017 | 28274240 |
| nkg2d modulates aggravation of liver inflammation by activating nk cells in hbv infection. | hepatitis b virus (hbv) infection is thought to be an immune-mediated liver disease. the mechanisms underlying natural killer (nk) cell group 2d receptor (nkg2d) that activates nk cells and participates in anti-hbv immunity and immunopathology has not been thoroughly elucidated. peripheral nkg2d(+) and ifn-γ(+) nk cells frequencies and intrahepatic nkg2d and ifn-γ mrna and protein expressions were determined in hbv-infected patients. levels of nkg2d and ifn-γ mrna and protein in nk cells, co-cul ... | 2017 | 28273905 |
| long term trends in chronic hepatitis b virus infection associated liver transplantation outcomes in the united states. | with effective antiviral therapies, rates of hepatitis b virus (hbv)-related hepatocellular carcinoma (hcc) and decompensated liver disease requiring liver transplantation (lt) are expected to decrease. we aim to evaluate overall trends in lt waitlist registrations, waitlist survival, and likelihood of receiving lt among chronic hbv patients in the u.s. using the united network for organ sharing database, we retrospectively evaluated adults (age >18) with chronic hbv (with and without hcc) liste ... | 2017 | 28273387 |
| expression of microrna-122 and microrna-22 in hbv-related liver cancer and the correlation with clinical features. | micrornas (mir) participate in cell proliferation, apoptosis and transformation, as they can regulate gene expression and intracellular signal transduction for various physiological processes. mir-122 and mir-22 are known to be related with occurrence and progression of hepatitis b virus (hbv)-related hepatocellular cancer (hcc). this study recruited hbv-related hcc patients, whose expression levels of mir-122 and mir-22 were determined to analyze the correlation with clinical and pathological i ... | 2017 | 28272709 |
| nucleic acid-based polymers effective against hepatitis b virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells. | nucleic acid polymers (naps) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis b virus (hbv) in patients. analysis of immunostimulatory properties of naps were conducted with several nap species: rep 2006, the prototypic degenerate nap [dn]40, containing tlr9-stimulatory cpg; rep 2055 a clinically active nap with a sequence [dadc]20 devoid of cpg content; rep 2139 (also clinically active) and rep 2165 (rep 2055 analog ... | 2017 | 28272460 |
| knowledge, attitude and behaviours towards recommended vaccinations among healthcare workers. | healthcare workers (hcws) are an important group of professionals exposed to biological risk during their work activities. so, the aim of this study is to perform a survey on the knowledge, attitude and behaviour of italian hcws towards the vaccinations recommended by the ministry of health. a cross-sectional study was carried out during the period september 2014-august 2015 in the lazio region. the study was conducted by recruiting hcws and biomedical students. the sample was comprised of 571 r ... | 2017 | 28272332 |
| a new oleanolic acid derivative against ccl₄-induced hepatic fibrosis in rats. | a novel hepatoprotective oleanolic acid derivative, 3-oxours-oleana-9(11), 12-dien-28-oic acid (oxy-di-oa), has been reported. in previous studies, we found that oxy-di-oa presented the anti-hbv (hepatitis b virus) activity (ic50 = 3.13 µg/ml). remarkably, it is superior to lamivudine in the inhibition of the rebound of the viral replication rate. furthermore, oxy-di-oa showed good performance of anti-hbv activity in vivo. some studies showed that liver fibrosis may affiliate with hbv gene mutat ... | 2017 | 28272302 |
| predictive value of serum alt and t-cell receptor beta variable chain for hbeag seroconversion in chronic hepatitis b patients during tenofovir treatment. | effective antiviral therapy plays a key role in slowing the progression of chronic hepatitis b (chb). identification of serum indices, including hepatitis b e antigen (hbeag) expression and seroconversion, will facilitate evaluation of the efficacy of antiviral therapy in hbeag-positive chb patients. the biochemical, serological, virological parameters, and the frequency of circulating cd4cd25 regulatory t cell (treg) in 32 patients were measured at baseline and every 12 weeks during 96 weeks of ... | 2017 | 28272219 |
| the expression of b7-h3 in circulating cd4+cd25high t cells, circulating cd14+ monocytes and plasma during hepatitis b virus infection progression. | b7-h3 is frequently upregulated in response to autoantigens and pathogens during host t cell immune responses. however, the role of b7-h3 which express in cd14+ monocytes and cd4+cd25high t cells had not been investigated. | 2017 | 28271685 |
| antiviral therapy in chronic hepatitis b with mild acute exacerbation. | the aim of this study was to assess the efficacy and safety of peginterferon α-2a (pegifn) and nucleos(t)ide analogues (na) treatments in patients with hepatitis b envelope antigen (hbeag)-positive chronic hepatitis b (chb) with mild acute exacerbation (ae). | 2017 | 28270871 |
| characterization of occult hepatitis b virus infection among hiv positive patients in cameroon. | occult hepatitis b infection (obi) among hiv positive patients varies widely in different geographic regions. we undertook a study to determine the prevalence of occult hepatitis b infection among hiv infected individuals visiting a health facility in south west cameroon and characterized occult hbv strains based on sequence analyses. | 2017 | 28270215 |
| role of hla-dp and hla-dq on the clearance of hepatitis b virus and the risk of chronic infection in a multiethnic population. | hbv infection exhibits geographical variation in its distribution in south america. while hbv rates are low in central argentina, the north-western region exhibits intermediate hbv rates. unfortunately, the reasons that could explain this difference are still unknown. | 2017 | 28267888 |
| microrna-125b-5p mediates post-transcriptional regulation of hepatitis b virus replication via the lin28b/let-7 axis. | micrornas (mirnas) are able to modulate hepatitis b virus (hbv) replication and play an important role in the pathogenesis of hbv infection. recently, we have identified that serum mir-125b-5p levels correlated with hbv dna levels and liver necroinflammation. in the present study, we addressed how mir-125b-5p regulated hbv replication at the different steps, inclduing viral transcription, assembly, and virion production and investigated the underlying mechanisms. we found that mir-125b-5p overex ... | 2017 | 28267418 |
| hepatitis b virus vaccination in hiv-infected people: a review. | hbv immunization is highly recommended in people infected with hiv. however, the classical schedule used in the general population has been shown to be insufficient in people living with hiv. this review summarizes the main studies dealing with hbv vaccination in people living with hiv, depending on their baseline status (in particular, never vaccinated, already vaccinated, or with an isolated anti-hbc serological profile). it shows that reinforced 40µg intramuscular hbv vaccination schedules ar ... | 2017 | 28267387 |
| reply to letter: "adjuvant antiviral therapy with nucleos(t)ide analogs in patients with hepatitis b virus--related hepatocellular carcinoma". | 2017 | 28266989 | |
| postoperative antiviral therapy with nucleos(t)ide analogs in patients with hepatitis b virus--related hepatocellular carcinoma. | 2017 | 28266988 | |
| prevention of liver tumor formation in woodchucks with established hepatocellular carcinoma by treatment with cationic liposome-dna complexes. | approximately 250 million people worldwide are chronically infected with hepatitis b virus (hbv) and more than half of the hepatocellular carcinoma (hcc) cases are attributed to this infection. as hcc has a high mortality rate, and current treatment options are remarkably limited, the development of new therapeutic treatment strategies is warranted. | 2017 | 28264666 |
| cure strategies for hepatitis b virus: the promise of immunotherapy. | chronic hepatitits b virus remains a public health challenge, infecting more than 240 million people globally and causing 600,000 deaths per year from end-stage liver disease and/or hepatocellular carcinoma. current antiviral therapeutic agents are highly effective at blocking viral replication, but discontinuation of therapy prior to loss of hepatitis b surface antigen generally leads to relapse. new modalities that target host factors of viral persistence such as immune response pathway inhibi ... | 2017 | 28263466 |
| characterization of gene expression profiles in hbv-related liver fibrosis patients and identification of itgbl1 as a key regulator of fibrogenesis. | although hepatitis b virus (hbv) infection is the leading cause of liver fibrosis (lf), the mechanisms underlying liver fibrotic progression remain unclear. here, we investigated the gene expression profiles of hbv-related lf patients. whole genome expression arrays were used to detect gene expression in liver biopsy samples from chronically hbv infected patients. through integrative data analysis, we identified several pathways and key genes involved in the initiation and exacerbation of liver ... | 2017 | 28262670 |
| adverse effects of oral antiviral therapy in chronic hepatitis b. | oral nucleoside/nucleotide analogues (nas) are currently the backbone of chronic hepatitis b (chb) infection treatment. they are generally well-tolerated by patients and safe to use. to date, a significant number of patients have been treated with nas. safety data has accumulated over the years. the aim of this article is to review and update the adverse effects of oral nas. nas can cause class adverse effects (i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. all nas ... | 2017 | 28261380 |
| preoperative lymphocyte-to-monocyte ratio predicts survival in primary hepatitis b virus-positive hepatocellular carcinoma after curative resection. | both inflammation and immunity are associated with the development of malignancy. the lymphocyte-to-monocyte ratio (lmr) has been confirmed as a prognostic factor for several malignant diseases. the purpose of our study was to analyze prognostic significance of preoperative lmr in hepatitis b virus (hbv)-related hepatocellular carcinoma after curative resection. | 2017 | 28260933 |
| higher serum interleukin-17a levels as a potential biomarker for predicting early disease progression in patients with hepatitis b virus-associated advanced hepatocellular carcinoma treated with sorafenib. | although sorafenib is the only available drug with proven efficacy for patients with advanced hepatocellular carcinoma (hcc), the clinical efficacy of sorafenib is variable and unpredictable. the aim of the current study was to identify potential serum biomarkers predicting cancer progression and overall survival (os) in patients with hepatitis b virus (hbv)-related advanced hcc treated with sorafenib. | 2017 | 28260649 |
| differential regulation of hepatitis b virus core protein expression and genome replication by a small upstream open reading frame and naturally occurring mutations in the precore region. | hepatitis b virus (hbv) transcribes two subsets of 3.5-kb rnas: precore rna for hepatitis b e antigen (hbeag) expression, and pregenomic rna for core and p protein translation as well as genome replication. hbeag expression could be prevented by mutations in the precore region, while an upstream open reading frame (uorf) has been proposed as a negative regulator of core protein translation. we employed replication competent hbv dna constructs and transient transfection experiments in huh7 cells ... | 2017 | 28260621 |
| a danish nationwide questionnaire study of hepatitis b virus screening before immunosuppressive therapy. | difficulty in identifying patients who are at risk for hepatitis b virus (hbv) reactivation makes it import-ant to screen for hbv before initiating immunosuppressive therapy. the aim of this study was to investigate screening procedures for hbv infection before initiation of immunosuppressive therapy and to explore hbv treatment strategies. | 2017 | 28260595 |
| living kidney donor cancellation at king hussein medical center. | living-related kidney donation is the main source of renal grafts in jordan, since kidneys from deceased donors are scarce. although the jordanian community accepts the idea of kidney donation to family members, not all potential donors manage to complete the required psychologic and medical evaluations. we review the causes of kidney-donation cancellation and suggest options to increase the number of available organs. | 2017 | 28260449 |
| low utility of fluorodeoxyglucose-positron emission tomography/computed tomography for detecting hepatocellular carcinoma in patients before liver transplantation. | our program routinely used fluorodeoxyglucose-positron emission tomography/computed tomography as part of the liver transplant evaluation of patients with hepatocellular carcinoma. the aim of this study was to evaluate the role of this imaging modality in the pretransplant work-up. | 2017 | 28260429 |
| th17/treg imbalance and increased interleukin-21 are associated with liver injury in patients with chronic severe hepatitis b. | th17/treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. the aim of the current study was to assess the treg/th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepatitis b virus (hbv) infection. | 2017 | 28259000 |
| [antiviral therapy in the third trimester to prevent mother-to-infant transmission of hepatitis b virus:benefit or harm?] | 2017 | 28253569 |