Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| distribution of mrna for cck-b receptor in the brain of mastomys natalensis: abundant expression in telencephalic neurons. | the distribution of cholecystokinin b (cck-b) receptors in the mastomys brain was studied using northern blot analysis and in situ hybridization technique. by northern blot analysis using 32p-labeled cdna probe, the cortex had the highest hybridization signal of cck-b receptor mrna in the brain. the olfactory bulb and hippocampus showed a moderate level of signals. in situ hybridization using 35s-labeled crna probes revealed a wide and region-specific distribution of cck-b receptor mrna in the t ... | 1994 | 8004467 |
| rapid induction of enterochromaffinlike cell tumors by histamine2-receptor blockade. | the effect of acid inhibition on gastric endocrine cells was investigated in praomys (mastomys) natalensis. long-term treatment (1 to 32 weeks) with an irreversible histamine 2-receptor blocker (loxtidine) caused a sustained increase in plasma gastrin levels, which was accompanied by a gradual increase in histamine and histidine decarboxylase activity of the gastric oxyntic mucosa. the density of endocrine cells in the oxyntic mucosa increased gradually, doubled by 8 weeks, and was three times t ... | 1993 | 8097370 |
| gastrin/cck-b receptors on brain, gastric parietal cells and ecl carcinoid tumor of mastomys natalensis. | cholecystokinin (cck)-8 and human gastrin i (gastrin) were found to be almost equipotent in displacing the specific binding of not only 125i-cck-8 but also 125i-gastrin to both ecl carcinoid tumor and parietal cell membranes of mastomys natalensis. these binding specificities of the native gastrin receptors for cck-8 and gastrin were identical to that of the cloned gastrin receptor from the ecl carcinoid tumor expressed on cho-k1 cells. in contrast, cck-8 was approximately 10-20 times as potent ... | 1993 | 8182917 |
| immunoreactive proteins of acanthocheilonema viteae (nematoda: filarioidea) adults: solubilization in various detergents. | for optimal solubilization of immunoreactive proteins of filarial parasites, adult worms of acanthocheilonema viteae were extracted in different detergents including anionic, cationic, nonionic and zwitterionic agents under varying incubation periods. each preparation was then analysed by sds-page and immunoblotting using pooled sera from mastomys natalensis infected with a. viteae. amongst the detergents used, maximum immunoreactive proteins were exposed by sodium dodecylsulphate (sds), closely ... | 1993 | 8314178 |
| characterization of gastrin/cck receptors on gastric carcinoid tumor membrane of mastomys natalensis. | recently, we identified the specific binding site for gastrin on the gastric carcinoid tumor of mastomys (praomys) natalensis. in this study, precise characterization of the gastrin binding site on these tumors was performed. both 125i-human gastrin i (gastrin) and 125i-cck-8 bound specifically to the cell membrane, and scatchard analysis revealed a high affinity binding site for each ligand with similar kd and bmax values. the specific binding of both 125i-gastrin and 125i-cck-8 was displaced i ... | 1993 | 8441820 |
| role of free radicals in plasmodium berghei infected mastomys natalensis brain. | lipid peroxide, lipid hydroperoxide, reduced glutathione, oxidised glutathione, lipofuscin contents and the activity of the enzyme superoxide dismutase were assessed in p. berghei infected m. natalensis brain. the results showed significant increase in the levels of lipid peroxides, lipid hydroperoxides and lipofuscin in brain subcellular fractions of p. berghei infected m. natalensis. furthermore, a depressed superoxide dismutase activity was observed along with regulation in glutathione conten ... | 1992 | 1294484 |
| studies on the infectivity of gametocytes of plasmodium berghei (nk 65) in anopheles stephensi. | the infectivity of gametocytes of plasmodium berghei (nk 65) has been studied in laboratory bred anopheles stephensi. mosquitoes were fed daily on infected male and female mastomys natalensis and subsequent development of the oocysts was monitored in the midguts. maximum number of oocysts were found in mosquitoes which were fed on infected female mastomys on d8 and in male mastomys on d7 post-inoculation. during the next peak of gametocytaemia, very few oocysts developed. these findings suggest ... | 1992 | 1296945 |
| primary structure of the e6 protein of micromys minutus papillomavirus and mastomys natalensis papillomavirus. | 1992 | 1319576 | |
| a decade of plague epidemiology and control in the western usambara mountains, north-east tanzania. | outbreaks of human plague have been occurring in the western usambara mountains since 1980, involving many cases and deaths. epidemiological surveys and control activities were carried out from june 1980 to may 1990. rodents were trapped live, identified and serologically tested for plague, using the passive haemagglutination and passive haemagglutination inhibition tests. rodent fleas were collected, processed, identified and counted. house fleas were caught with light traps and similarly treat ... | 1992 | 1356303 |
| plague in lushoto district, tanzania, 1980-1988. | rodents were live-trapped in selected plague-inflicted villages from june 1980 to march 1988. flea infestation rates were determined and the animals were serologically tested for plague. clinically suspected and clinically healthy people in the affected areas were similarly tested for plague antibodies. of 1596 rodent sera tested, 91 (5.7%) were positive for plague. these were mostly from rattus rattus, mastomys natalensis, otomys spp. and pelomys fallax. a total of 1772 fleas, of which dinopsyl ... | 1992 | 1440831 |
| effect of picroliv on glutathione metabolism in liver and brain of mastomys natalensis infected with plasmodium berghei. | administration of picroliv, the active principle from picrorhiza kurrooa, at a dose of 6 mg/kg, po for two weeks showed significant protection against changes in liver and brain glutathione metabolism of plasmodium berghei infected mastomys natalensis. the depletion of reduced glutathione level and inhibition of glutathione-s-transferase, glutathione reductase and glutathione peroxidase activities due to p. berghei infection were markedly recovered by picroliv. the increased levels of lipid pero ... | 1992 | 1459651 |
| identification of circulating parasite acetylcholinesterase in human and rodent filariasis. | in the present study, the enzyme acetylcholinesterase (ache) from filarial parasites was identified in sera from humans infected with onchocerca volvulus as well as in mastomys natalensis infected with brugia pahangi. the enzyme was present in immune complexes precipitated with cold 4% polyethylene glycol. the infected sera showed 3-4 times more ache activity than did normal sera, and enzyme activity could be demonstrated in 5% polyacrylamide gels by specific staining. the enzyme from infected s ... | 1992 | 1480604 |
| effect of 2,2'-dicarbomethoxylamino-5,5'-dibenzimidazolyl ketone on antioxidant defenses of acanthocheilonema viteae and its laboratory host mastomys natalensis. | the effect of the macrofilaricidal agent of 2,2'-dicarbomethoxylamino-5,5'-dibenzimidazolyl ketone (c.d.r.i. compound 82/437), on the metabolism of reactive oxygen species (ros) in acanthocheilonema viteae and mastomys natalensis was measured following intraperitoneal administration at therapeutic doses. the recovered worms possessed substantially reduced levels of catalase and glutathione peroxidase (gpx), and thus were less able to detoxify h2o2. nonetheless, the subcutaneous and adjoining mus ... | 1992 | 1510719 |
| cloning and characterization of gastrin receptor from ecl carcinoid tumor of mastomys natalensis. | we report here the cdna cloning of a putative gastrin receptor from enterochromaffin-like (ecl) carcinoid tumor of mastomys natalensis. for this study, we used the polymerase chain reaction technique to amplify transmembrane domain sequences related to rat pancreatic cholecystokinin (cck)-a receptor from the ecl tumor cdna library. the amino acid sequence deduced from the cloned cdna showed 85.7% and 49.0% identity to canine parietal cell gastrin receptor and rat pancreatic cck-a receptor, respe ... | 1992 | 1530611 |
| brugia malayi in mastomys natalensis: efficacy of mebendazole in combination with freund's complete adjuvant. | the chemotherapeutic efficacy of mebendazole given in combination with freund's complete adjuvant (fca) against brugia malayi in multimammate rat was evaluated. animals treated with mebendazole, orally at 200 mg/kg x 5 consecutive days along with fca given subcutaneously (s.c.) on day -10, day 0 and day +15 of the drug treatment killed 48.51% of the adult worms. this drug given alone at the same regimen and by the same route showed only 18.7% mortality rate on adults. mebendazole given intraperi ... | 1992 | 1644349 |
| humoral immune response to infective larval antigen in brugia malayi infected mastomys natalensis. | the sequential changes in the humoral immune response against infective larval antigens during the course of brugia malayi infection in mastomys natalensis have been studied using enzyme linked immunosorbent assay. igm antibody against b. malayi infective larval excretory secretory (es) antigen was detected in the peripheral circulation within a week of infection, whereas igm antibody against b. malayi infective larval somatic antigen and igg antibody against both somatic and es antigens were de ... | 1991 | 1674404 |
| the ngf complex from the african rat mastomys natalensis. | the 7s ngf complex from the male mouse submaxillary gland consists of the alpha, gamma, and beta subunits in the ratio alpha 2 gamma 2 beta. the beta (ngf) subunit contains all the known biolocial activity of 7s ngf. the alpha and gamma subunits are both members of glandular kallikrein gene family, yet only gamma subunit has protease activity. the gamma subunit plays a role in the processing of preprongf to its mature form, while the role of the alpha subunit is not yet understood. despite the f ... | 1991 | 1791910 |
| impact of surface modifications of acanthocheilonema viteae microfilariae on cell adhesion. | exposure of a. viteae microfilariae to various lectins reduced their capacity to react with the peritoneal exudate cells of the host, mastomys natalensis. sugars corresponding to these lectins with the exception of n-acetyl glucosamine, did not affect the adhesion per se. they however, protected the parasite against the adverse effect of lectins. neuraminidase and chitinase also suppressed adhesion capacity of the microfilariae. except sodium dodecylsulphate which enhanced cell attachment, other ... | 1991 | 1814837 |
| cyclic amp level in red blood cells of plasmodium berghei-infected mastomys natalensis. | the present report describes the changes in cyclic amp level which occur upon parasitization of red cells by plasmodium berghei. parasitized erythrocytes were separated from the non-parasitized population by percoll density-gradient centrifugation. an increase in the cyclic amp content of both non-parasitized and parasitized erythrocytes of infected animals compared with that of uninfected animals was observed. the patterns of physiological response to isoproterenol in normal, parasitized and no ... | 1991 | 1849086 |
| on the pathogenesis of anaemia and leukopenia in filarial (litomosoides carinii) infection of mastomys natalensis. | mastomys natalensis infected with the filarial parasite litomosoides carinii show anaemia and leukopenia. alterations start with the onset of microfilaraemia. anaemia is temporally macrocytic (up to 80 days after infection), subsequently normocytic and hypochromic, accompanied by reticulocytosis. increased intravascular haemolysis (i) and functional disorders of the haemopoetic system (ii) are involved in the pathogenesis. i: circulating erythrocytes showed increased osmofragility. hypoglycaemia ... | 1991 | 1853669 |
| ultrastructure of the submandibular gland in the african multimammate rodent, praomys natalensis. | praomys natalensis, an african rodent that is phenotypically and cytogenetically intermediate to rats and mice, possesses a submandibular gland that is histologically similar to that in both of these near relatives, but is ultrastructurally unique. acinar cells, which are seromucous in nature, contain secretory granules that often contain a perfect "bull's eye" inclusion (or some variant of this configuration) suspended in a dense matrix. the golgi apparatus in these cells has an unusual structu ... | 1991 | 2012308 |
| immune responses of two mastomys sibling species to yersinia pestis. | this study assessed the in vitro cell-mediated immune responses of mastomys natalensis, with a diploid chromosome number of 2n = 32, and mastomys coucha, with a diploid chromosome number of 2n = 36, to yersinia pestis. splenic mononuclear (mn) cells of uninfected m. natalensis proliferated in response to crude fraction 1 of y. pestis and two subfractions derived from fraction 1 in vitro. proliferation was dose dependent and followed the time kinetics of other well-known mitogens. further charact ... | 1991 | 2037358 |
| ultrastructure of the sublingual gland in the african multimammate rodent. | the sublingual gland of praomys natalensis, an african rodent that is phenotypically and cytogenetically intermediate to mice and rats, is a mixed gland, consisting of mucous acini that are capped by serous demilunes, of intercalated ducts, and of some short striated ducts that quickly become excretory ducts. the mucous cells are typical in appearance, with lucent granules that contain an assortment of scattered vermiform or particulate densities. the serous cells display an array of secretory g ... | 1991 | 2048752 |
| receptors for gastrin on gastric carcinoid tumor membrane of mastomys natalensis. | specific binding sites for human gastrin i (gastrin) were identified in a crude membrane preparation from the gastric carcinoid tumor of mastomys (praomys) natalensis. the binding of 125i-gastrin to the carcinoid tumor membrane was saturable, and scatchard analysis of the data revealed a single class of binding site with a dissociation constant of 139.2 pm and a maximal binding capacity of 23.5 fmol/mg protein. gastrin and cck8 equipotently and dose-dependently displaced the binding of 125i-gast ... | 1991 | 2049096 |
| activation of latent papillomavirus genomes by chronic mechanical irritation. | the skin of animals of a laboratory strain of mastomys natalensis carrying endogenous, latent papillomavirus genomes was irritated by scratching with glasspaper. hyperproliferation of the epidermis and amplification of viral dna followed this treatment, and in approximately 27% of the animals virus-producing papillomas were induced. | 1991 | 1658206 |
| significance of gastric endocrine tumor and age-related gut peptide alterations in mastomys. | the mastomys (praomys natalensis) species are a unique natural model in which the bioactivity of gastric carcinoids may be studied. several investigators have previously demonstrated that these tumors contain large amounts of histamine. in this study we investigated the presence of peptides associated with the neoplasm. the levels and location of gastrin, gastric inhibitory peptide (gip), neurotensin, peptide yy (pyy), pancreatic polypeptide (pp), glucagon, bombesin, vasoactive intestinal peptid ... | 1990 | 2326498 |
| cell renewal in non-specific duodenitis, ulcer-related duodenitis and duodenal ulcer. experiments in mastomys (praomys natalensis). | cell renewal in the duodenal mucosa of mastomys was studied by autoradiography 1 and 24 h after intraperitoneal injection of tritiated thymidine. non-specific duodenitis and duodenal ulceration were produced with a continuous infusion of histamine. mucosal renewal in the duodenum of 30 control mastomys was compared with 30 which received histamine dihydrochloride for 5 days. no abnormality developed in the controls, but 11 of the experimental group developed non-specific duodenitis and 12 duoden ... | 1990 | 2351240 |
| antifilarial activities of benzazole derivatives. 3. effects of benzothiazoles on third stage larvae and preadult worms of acanthocheilonema viteae, brugia malayi and b. pahangi in mastomys natalensis. | ten structurally defined benzothiazoles (5-methyl and the analogous 5-methoxy derivatives) with known macrofilaricidal and microfilaricidal activities were tested for efficacy against third stage larvae and preadult worms in acanthocheilonema viteae, brugia malayi, and b. pahangi infected mastomys natalensis. drugs were administered in single oral doses of maximally 100 mg/kg. the benzothiazoles were active against the two stages of the three species. generally the 5-methoxy derivatives displaye ... | 1990 | 2075385 |
| absence of papillomavirus in skin tumors induced in sencar mice by a two-stage carcinogenesis protocol. | sencar mice are unusually sensitive to induction of papillomas and squamous cell carcinomas by initiation with 7,12-dimethylbenzanthracene (dmba) and promotion by 12-o-tetradecanoylphorbol-13-acetate (tpa). tumors induced by this protocol were tested for the presence of papillomavirus by immunohistochemistry, southern blot, reverse southern blot and dot blot hybridization techniques. papillomavirus antigens were not detected in any of 235 tumors or 142 non-tumor-bearing skin samples analyzed. so ... | 1990 | 2154340 |
| evaluation of hepatoprotective activity of picroliv (from picrorhiza kurroa) in mastomys natalensis infected with plasmodium berghei. | administration of picroliv, a standardized fraction of alcoholic extent of picrorhiza kurroa (3-12 mg/kg/day for two weeks) simultaneously with p. berghei infection showed significant protection against hepatic damage in mastomys natalensis. the increased levels of serum glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), alkaline phosphatase, lipoprotein-x (lp-x) and bilirubin in the infected animals were marked reduced by different doses of picroliv. in the liver, ... | 1990 | 2189829 |
| igg response of rats to the excretory-secretory products of litomosoides carinii. | the nature of antibody responses to the excretory-secretory (es) products of adult worms and microfilariae (mf) of litomosoides carinii in albino rats and their possible role in protection have been studied. rats were immunized with es products derived from in vitro incubation of adults or mf. the sera from these rats promoted neutrophil-mediated killing of mf in vitro. the antibody responsible for the cytocidal activity was identified as igg isotype. indirect fluorescent antibody test showed th ... | 1990 | 2191288 |
| hepatic superoxide dismutase, catalase and lipid peroxidation products in mastomys natalensis infected with plasmodium berghei. | p. berghei infection in m. natalensis caused a significant reduction in the hepatic sod and catalase activities. cu-zn sod was more susceptible to infection than mn sod. the inhibition of enzyme activities was associated with marked increase in the levels of lipid peroxides, lipid hydroperoxides and conjugated dienes in infected m. natalensis. the alterations in the hepatic sod, catalase and lipid peroxides are related with the severity of infection. | 1990 | 2196223 |
| acute and chronic bacterial prostatitis due to e. coli. description of an animal model. | inoculation of escherichia coli (serotype o:6) into the bladder of male and female mastomys (praomys) natalensis produced severe prostatitis. in this rodent both male and female animals possess a well developed prostatic gland. the histologic and microbiologic course of the prostatic infection resembled strongly the human disease. acute bacterial prostatitis was followed by the development of chronic bacterial or nonbacterial prostatitis. the infection persisted in some animals for up to six mon ... | 1990 | 2204173 |
| susceptibility of mastomys natalensis to brugia malayi following pretreatment with antifilarials. | mastomys natalensis pretreated with diethylcarbamazine (dec), levamisole or centperazine were exposed to the standard inoculum of infective larvae of brugia malayi. percentage 'take' of infection, duration of prepatent period, course of microfilaraemia and number of adult worms recovered were compared with those of untreated infected mastomys (control). dec and centperazine did not alter the 'take' (dec/centperazine: 100%; control: 88.24%) and the average prepatent period (dec: 105.44 days; cent ... | 1990 | 2227711 |
| antioxidant enzymes in acanthocheilonema viteae and effect of antifilarial agents. | adult worms of acanthocheilonema viteae were found to be susceptible to the reactive oxygen intermediates (roi) generated by the xanthine-xanthine oxidase (x-xo) system. the damage caused by this system was completely abolished by superoxide dismutase (sod) and catalase but not by mannitol. the results, therefore, suggest that superoxide anions (o2-) and hydrogen peroxide (h2o2) alone or in combination might be toxic to the filariid. a. viteae exhibited the presence of an active enzyme system to ... | 1990 | 2244937 |
| a comparative study of the infectivity of t.b. rhodesiense isolates from man to 3 species of small laboratory rodents. | to confirm an earlier observation, that some t.b. rhodesiense isolates from sleeping sickness cases had failed to infect normally susceptible wistar rats, blood samples, freshly drawn from 21 patently parasitaemic ss patients, were each inoculated simultaneously into 3 swiss t.o. white mice, 3 young wistar rats and 3 mastomys natalensis. with the sole exception of one mastomys, which failed to become infected, the 21 stocks infected all the inoculated rodents. levels and durations of parasitaemi ... | 1990 | 2279470 |
| [the dynamic activity of lymphocyte succinate dehydrogenase and its correlations in experimental malaria]. | succinic dehydrogenase (sdh) activity in peripheral blood lymphocytes has been studied in progressing experimental malaria on a p. yoelii model, the strain 265 by; the multinipple rats mastomys natalensis. cytochemical method employing n-nitrotetrazolium violet was used. comparative analysis of changes in sdg activity in peripheral blood lymphocytes and changes in the level of parasitemia has demonstrated that day 10 was a critical period when there was an evident inverse correlation between the ... | 1990 | 2290392 |
| immune response to acanthocheilonema viteae infection in multimammate rats (mastomys natalensis). | the multimammate rat mastomys natalensis, when infected with the filarial parasite acanthocheilonema viteae, develops amicrofilaraemia. worm recovery and the duration and intensity of microfilaraemia were analysed and related to the humoral and cellular immune responses of the host by using an antibody-dependent cell-mediated cytotoxicity (adcc) assay towards microfilariae (mf). mf were detected in the peripheral blood at 7 weeks post-infection (p.i.), reaching maximum levels by 20 weeks p.i., a ... | 1990 | 2318510 |
| intra-ocular transplantation of carcinoid tumours from mastomys and humans. | carcinoid tumours from man and mastomys (praomys) natalensis produce a variety of peptide hormones. the study of these peptide-secreting tumours has been difficult because of the small amount of tissue available and because of limitations with present cell culture systems. the aim of this study was to establish an experimental model where carcinoid tumours could be maintained and their hormone secretion studied. the intra-ocular transplantation technique was chosen for its simplicity and high ra ... | 1990 | 2358971 |
| effect of ivermectin on filariae of mastomys natalensis. | the efficacy of ivermectin (iv) was evaluated against four species of filariae, litomosoides carinii, acanthocheilonema viteae, brugia pahangi and brugia malayi in mastomys natalensis. animals with patent infections, induced with l3 larvae, by intravenous (iv) infusion of the respective microfilariae (mf) (5 x 10(4) mf per animal) or by intraperitoneal (ip) route (2 x 10(4) mf per animal) were used in this study. a single dose of iv (100 micrograms.kg-1) given subcutaneously (sc) to mastomys inf ... | 1990 | 2381895 |
| mastomys natalensis or mastomys coucha. correct species designation in animal experiments. | haemoglobin electrophoresis and chromosome analysis indicate that the widely used multimammate rat (chamois coloured) as experimental animal belongs to the species mastomys coucha (smith, 1836) and not, as commonly assumed, to mastomys natalensis (smith, 1834). | 1990 | 2382103 |
| immunoprophylaxis against filarial parasite, dipetalonema viteae in multimammate rat mastomys natalensis: immunisation with adult worm antigens. | 1990 | 2401531 | |
| gamma-glutamyl-transpeptidase in lymphatic tissues of mastomys natalensis during an infection with acanthocheilonema viteae. | during acanthocheilonema viteae infection, the specific activity of gamma-glutamyltranspeptidase (gamma-gt) increased in peritoneal exudate cells and bone marrow and decreased in lymph nodes of mastomys natalensis throughout the course of infection. however, though there was an increase in specific activity of gamma-gt in thymus and spleen during the prepatent phase of a. viteae infection, the level either returned to normal or decreased during the latent phase of infection. a close correlation ... | 1990 | 1973658 |
| viremia and antibody response of small african and laboratory animals to crimean-congo hemorrhagic fever virus infection. | eleven species of small african wild mammals, laboratory rabbits, guinea pigs, and syrian hamsters were infected with crimean-congo hemorrhagic fever (cchf) virus. low-titered viremia followed by development of antibody was observed in scrub hares (lepus saxatilis), cape ground squirrels (xerus inauris), red veld rats (aethomys chrysophilus), white tailed rats (mystromys albicaudatus), bushveld gerbils (tatera leucogaster), striped mice (rhabdomys pumilio), and guinea pigs. the maximum viremic t ... | 1989 | 2499205 |
| adenocarcinoma and carcinoid developing spontaneously in the stomach of mutant strains of mastomys natalensis. | neoplastic and nonneoplastic lesions developing spontaneously in antral and fundic mucosae of stomachs of mutant chamois-coloured z (130 animals) and y (67 animals) strains of mastomys aged 18 to 24 months were examined histologically and histochemically. the z strain developed both antral lesions (hyperplasia 29.2%; dysplasia 23.8%; adenocarcinoma 17.7%) and fundic carcinoid(s) (72.3%). the antral lesions were limited to the lesser curvature near the pyloric ring. macroscopically, adenocarcinom ... | 1989 | 2512742 |
| seasonal patterns of rodents, fleas and plague status in the western usambara mountains, tanzania. | field and commensal rodents were live-trapped at three villages in an active focus of plague (yersinia pseudotuberculosis pestis) in lushoto district, western usambara mountains, tanga region, tanzania, from december 1983 to november 1984. their flea ectoparasites were collected, identified and counted. the rodent carcasses were serologically examined for specific plague antibodies and antigens, and bacteriologically examined for bipolar staining bacilli. a total of 1758 traps were set during th ... | 1989 | 2519642 |
| brugia malayi: status of host during different stages of infection. | the status of glycogen, protein, lipid components, lipid peroxides and a few enzymes of energy metabolism was studied in liver of mastomys natalensis during the development of brugia malayi infection. glycogen and lipid contents were decreased during the patent phase of infection while total protein was slightly altered in latent animals. phospholipid and triglyceride contents declined at prepatent and patent phase of infection. the levels of lactate and malate dehydrogenases, as well as of aden ... | 1989 | 2527791 |
| identification of papillomaviral dna sequences in hairless mouse tumours induced by ultraviolet irradiation. | papillomas, carcinomas in situ and squamous cell carcinomas were induced using ultraviolet irradiation in the hairless mouse strain mus musculus hra/skh. dna extracted from biopsies was examined using mastomys natalensis papillomaviral dna as a hybridization probe at reduced stringency. sequences homologous to the probe were detected in 16 of 24 papillomas, five of five carcinomas in situ and six of 38 squamous cell carcinomas. a number of tumour dnas (16/33) also hybridized with mixed dnas of h ... | 1989 | 2543760 |
| enhancement of u.v.-induced skin carcinogenesis in the hairless mouse by inoculation with cell-free extracts of skin tumours. | the presence of papillomaviral-like dna has been described in ultraviolet light-induced tumours in the skin of the hairless mouse (14). here we describe the effects of the inoculation of cell-free extracts of ultraviolet light-induced tumours into the scarified skin of normal hairless mice, prior to exposure of the mice to a cumulative carcinogenic dose of ultraviolet light. extracts from papillomas or squamous cell carcinomas enhanced the susceptibility of the inoculated mice to ultraviolet lig ... | 1989 | 2560465 |
| 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone--a new antifilarial agent. | the activity of 2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl ketone (ii, c.d.r.i. comp. 82/437) has been evaluated for its micro- and macro-filaricidal efficacy against litomosoides carinii in rodents. a dose of 3 mg/kg (i.p.) and 50 mg/kg (oral) x 5 days of comp. 82/437 was found to eliminate almost 100% of adult worms and microfilariae of l. carinii in cotton rat. it also killed 100% and 97% of adult worms and microfilariae of dipetalonema viteae and brugia malayi in mastomys natalensis resp ... | 1989 | 2575867 |
| in vitro drug sensitivity of trypanosoma gambiense isolates. | drug sensitivities of seven trypanosoma b. gambiense isolates from patients in the ivory coast were measured for mel b, suramin and lomidine using an in vitro incorporation test. bloodstream forms were isolated from mastomys natalensis, incubated in serial drug dilutions in a microtiter plate, after 24 h, radiolabeled hypoxanthine was added, and the plate incubated for another 15 h. trypanosomes were then harvested onto glass fiber filters with a cell harvester and incorporation of label was det ... | 1989 | 2575872 |
| xanthine oxidase, superoxide dismutase, catalase and lipid peroxidation in mastomys natalensis: effect of dipetalonema viteae infection. | status of xanthine oxidase, superoxide dismutase, catalase and lipid peroxidation, the enzymes metabolizing reactive oxygen intermediates in liver, lungs and spleen of m. natalensis during d. viteae infection was investigated. xanthine oxidase and lipid peroxidation exhibited stimulation, while superoxide dismutase and catalase showed depression in liver and spleen of the infected animals. the filarial infection therefore appears to create o2 toxicity in these tissues. lungs, on the other hand w ... | 1989 | 2633968 |
| ontogeny of ookinete of plasmodium berghei (nk 65): a scanning electron microscopic study. | the ontogeny of ookinete of plasmodium berghei (nk 65) was studied in vector anopheles stephensi fed on infected mastomys natalensis. the round zygote transformed into an ookinete after passing through following stages-1 gram-seed shaped zygote, 2 comma-shaped stage, 3 semilunar and 4 banana shaped ookinete. each fully formed ookinete had a 'conule' at the anterior end of the body. in some ookinetes under sem a depression was observed in the posterior half of the body. the function of the depres ... | 1989 | 2681394 |
| binding properties of diethylcarbamazine. | diethylcarbamazine (dec) reacted with liver cell plasma membrane of rodent hosts-cotton rat, albino rat and mastomys natalensis exhibiting the presence of both saturable and unsaturable components. the presence of lectins or sugar derivatives did not affect the binding significantly. the drug showed similar binding pattern with serum but the saturation was reached at a much lower concentration of the ligand. data obtained with a variety of macromolecules, particularly with the homopolymers of am ... | 1989 | 2695456 |
| hepatoprotective activity of silymarin against hepatic damage in mastomys natalensis infected with plasmodium berghei. | silymarin, a flavolignan from the seeds of silybum marianum, showed significant hepatoprotective activity in p. berghei-induced hepatic damage in m. natalensis, as assessed by changes in several serum and liver biochemical parameters. changes in lipoprotein-x, got, gpt, alkaline phosphatase and bilirubin were found to be protected by silymarin at different doses. maximum activity was observed at a dose of 5 mg/kg bw, po. silymarin had no effect on parasitaemia. | 1989 | 2697691 |
| hepatic low density lipoprotein receptor binding and lipid profile in mastomys natalensis during plasmodium berghei infection. | plasmodium berghei infection to mastomys natalensis showed hyper beta-lipoproteinemia. the increase in serum cholesterol is associated with decreased uptake of low density lipoprotein (ldl) by the liver through receptor mediated endocytosis. the membranes prepared from infected m. natalensis exhibit up to 50% decline in high affinity binding sites for human 125i-ldl. significant increases in serum lipids, cholesterol, triglyceride and lipid peroxide (lpo) contents of liver membrane were observed ... | 1989 | 2698856 |
| altered immune response (humoral and delayed-type hypersensitivity reactions) to sheep red blood cells in the course of experimental filarial infections (litomosoides carinii, brugia malayi, acanthocheilonema viteae) of mastomys natalensis. | litomosoides carinii-, acanthocheilonema viteae- or brugia malayi-infected mastomys natalensis were sensitised against sheep red blood cells (srbc) on various occasions after infection to determine the effect of filarial infections on the immune response to a non-filarial antigen. the phagocytic activity of the reticuloendothelial system (res) was controlled in vivo by the elimination of 51cr-labelled srbc. antibody titres against srbc (agglutinating and lytic antibodies) were similar to those o ... | 1989 | 2726721 |
| studies on the activity of the ciba geigy compounds cgp 6140, 20376, 20309 and 21833 against third and fourth stage larvae of onchocerca volvulus. | the effect of four new antifilarial compounds, (cgp 6140, 20376, 20309 and 21833, ciba geigy ltd. basle) on the viability of third and fourth stage larvae of onchocerca volvulus was tested in vitro and in vivo. the motility of the larval stages and the moulting process from the third to the fourth stage were used as parameters for the drug activity in vitro. all four compounds showed good effects in vitro on the moulting rates compared to the controls after incubation at different concentrations ... | 1989 | 2740728 |
| 19s and 7s antibody response of mastomys natalensis in experimental filarial (litomosoides carinii, acanthocheilonema viteae, brugia malayi, b. pahangi) infections. | specific total antibody (ab), 19s and 7s ab levels in the serum of m. natalensis were investigated after infection with l. carinii, a. viteae, b. malayi and b. pahangi for period of about 500 days p.i., using elisa (homologous adult antigen) and indirect immunofluorescence tests (iift: homologous adult and microfilariae antigen). total ab levels in l. carinii infected animals rose moderately during prepatency maximum levels occurred during patency. the response during prepatency was stronger in ... | 1989 | 2781895 |
| mammary gland growth and response to hormones in mastomys compared with mice. | mammary gland growth with or without hormone manipulation was examined in virgin mastomys (praomys (mastomys) natalensis) and compared with c3h/he mice having a low mammary tumor incidence. mammary glands of mastomys consisted mostly of duct systems even at 720 days of age, whereas conspicuous formation of normal end-buds and preneoplastic hyperplastic alveolar nodules were seen in the glands of mice after 180 days of age. mammary glands of mastomys showed a higher response to estrogen or proges ... | 1989 | 2761236 |
| characterization of histamine receptors in tracheal smooth muscle of mastomys natalensis. | the tracheal smooth muscle of mastomys natalensis contracted with carbachol administration while histamine (h) caused concentration-dependent relaxation. the specific h2-receptor agonists 4-methyl histamine, dimaprit, impromidine and a high concentration of 2-methyl histamine (h1-agonist) caused relaxation similar to h which was selectively blocked by cimetidine. low concentrations (10(-5)-10(-4) mol/l) of 2-methyl histamine and of h (10(-8)-10(-7) mol/l) occasionally produced small contractions ... | 1989 | 2816396 |
| blood leucocytes in mastomys natalensis with filarial infections. | 1988 | 3229786 | |
| intracisternal a particle gene related sequences are present in multiple copies in normal tissues and tumors of mastomys natalensis (muridae). | 1988 | 3340555 | |
| cytochemical demonstration of enzymatic activities of the parotid, submandibular, and sublingual glands of praomys (mastomys) natalensis. | histochemical techniques were applied to salivary glands removed from adult multimmate rodents (praomys) of either sex to detect and localize the following enzymatic activities: acid and alkaline phosphatase, arylsulphatase, ali-esterases, beta-glucuronidase, n-acetyl-betaglucosaminidase, and l-leucyl-aminopeptidase. no reaction was observed for alkaline phosphatase and glucuronidase. the glands reacted differently to the other enzymatic activities. alkaline phosphatase and glucosaminidase were ... | 1988 | 3415628 |
| angiostrongylus sandarsae alicata, 1968 (nematoda: metastrongyloidea) from praomys natalensis in kenya. | 1988 | 3373927 | |
| cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the european harvest mouse (micromys minutus). | individuals in a colony of european harvest mice (micromys minutus) were diagnosed with a variety of skin tumors including papillomas, trichoepitheliomas, and sebaceous carcinomas. papillomavirus group-specific antigens and viruslike particles were detected in the papillomas. a 7.6-kilobase supercoiled circular dna, which was cleaved once by ecori, was visualized in papilloma extracts by low-stringency southern blot hybridization with a bovine papillomavirus type 2 probe. the molecule was cloned ... | 1988 | 2824849 |
| comparison of cortical adrenergic, cholinergic and benzodiazepine receptors between albino rat and desert rat (mastomys natalensis) using radioreceptor binding. | cortical alpha-adrenergic, beta-adrenergic, cholinergic (muscarinic) and benzodiazepine receptors have been studied in the albino rat and mastomys natalensis (desert rat) using radioligand binding. scatchard analysis was performed to determine affinity (kd) and density (bmax) of receptors. compared to the albino rat, the desert rat was found to have higher affinity and density of alpha-adrenergic receptors. beta-adrenergic receptors had similar kd in both species but bmax was significantly lower ... | 1988 | 2841694 |
| [stimulation of the development of chloroquine-sensitive and -resistant strains of plasmodium falciparum by cocultivation with mastomys natalensis cells]. | 1988 | 3050413 | |
| stage-specific protective immunity to microfilariae of litomosoides carinii in mastomys natalensis. | 1988 | 3058997 | |
| litomosoides carinii in rodents: immunomodulation in potentiating action of diethylcarbamazine. | the antifilarial activity of combination of diethylcarbamazine (dec) and an immunomodulator, n-palmitoylmuramyl-l-alanyl-d-isoglutamine (np-mdp) was evaluated against litomosoides carinii in cotton rat (sigmodon hispidus) and mastomys natalensis. dec was used at 6 mg/kg in cotton rat whereas it was 75 mg/kg x 5 days in mastomys. the immunomodulator was administered at 62.5 to 500 micrograms/animal x 2 days. combination therapy with optimum dose of immunomodulator resulted in prolonged and signif ... | 1988 | 3075985 |
| the ngf and kallikrein genes of mouse, the african rat mastomys natalensis and man: their distribution and mode of expression in the salivary gland. | the kallikrein genes and their expression in the salivary glands of mouse, the african rat mastomys natalensis and human were compared. the mastomys kallikrein genes comprise a family of genes similar to those of mouse. androgen markedly enhances transcription of glandular nerve growth factor (ngf) and kallikrein in both male and female mastomys suggesting the presence of testosterone regulated kallikrein genes for growth factor precursor-processing in both sexes. in contrast, although a kallikr ... | 1988 | 3133079 |
| stage-specific antibody response of mastomys natalensis during the course of dipetalonema viteae infection. | stage-specific haemagglutinating (ha) and precipitin antibodies (pa) to infective larvae (l3), adult worms and microfilariae (mf) have been demonstrated in sera of mastomys natalensis during the course of dipetalonema viteae infection using indirect haemagglutination (iha) and ouchterlony's gel-diffusion tests. l3-specific ha antibody titre was shown to be quite low and lasted for shorter period whereas adult-specific antibody response was significantly higher and persisted for longer duration ( ... | 1988 | 3143649 |
| status of biogenic amines in lungs of mastomys natalensis during development of brugia malayi infection. | 1988 | 3182033 | |
| the high molecular weight nerve growth factor complex from mastomys natalensis differs from the murine nerve growth factor complex. | both the male and the female of mastomys natalensis, an african rat, have high levels of nerve growth factor (ngf) in their submaxillary glands. mastomys high molecular weight (hmw) ngf was purified by gel filtration and ion-exchange chromatography and was compared with hmw ngf from the male mouse submaxillary gland. mastomys hmw ngf sediments as a 5s species, does not exhibit esterase activity, and is more difficult to dissociate at acid ph than mouse 7s ngf. the biological activity could be is ... | 1988 | 3196680 |
| antifilarial activities of benzazole derivatives. 2. microfilaricidal effects against litomosoides carinii, acanthocheilonema. vitae, brugia malayi and b. pahangi in mastomys natalensis. | the spectrum of antimicrofilarial activities of eighteen 2-tertbutylbenzazole derivatives was evaluated comparatively in mastomys natalensis infected with litomosoides carinii, acanthocheilonema viteae, brugia malayi or b. pahangi. the minimal effective dose (dem) against microfilariae (greater than 95% reduction of microfilariae counts in the peripheral blood) was determined on day 3 (dem-3), on day 7, 14, 21, 28 and 42 (dem-7, dem-14, dem-21, dem-28 and dem-42) after the first treatment. all c ... | 1988 | 3227232 |
| molecular cloning of a cdna encoding the nerve growth factor precursor from mastomys natalensis. | mastomys natalensis is an african rat that has high levels of nerve growth factor (ngf) in its submaxillary glands. like in the mouse, mastomys ngf is found as a high-molecular-weight complex. however, the mastomys complex differs from the mouse complex, in that the gamma-subunit is either missing or is less tightly bound in the mastomys ngf complex. in the mouse, the gamma-subunit has been implicated in the processing of the beta-ngf precursor. the possible lack of gamma-subunits in the mastomy ... | 1988 | 3234767 |
| macrofilaricidal activity of oral flubendazole on brugia pahangi. | the macrofilaricidal effect of orally administered flubendazole on brugia pahangi was studied in the multimammate rat, mastomys natalensis. a micronized formulation was incorporated in the routine feed for 2 weeks, starting 16 weeks after infection. in the treated rats the microfilarial density dropped to zero 20 weeks after infection, whereas it remained high in untreated animals. when killed between 40 and 41 weeks after infection, the treated group yielded a mean of 2 male and 0.16 female wor ... | 1988 | 3256991 |
| antifilarial activities of benzazole derivatives. 1. macrofilaricidal effects against litomosoides carinii, dipetalonema viteae, brugia malayi, and b. pahangi in mastomys natalensis. | eighteen 2-tert-butyl-benzazole derivatives were evaluated comparatively as macrofilaricidal agents against l. carinii (l.c.), d. viteae (d.v.), b. malayi (b.m.) and b. pahangi (b.p.). upon repeated treatment (once daily) for five consecutive days the eight benzoxazole derivatives were invariably less potent than the corresponding benzothiazole derivatives. the minimal curative dose (dcm) of the benzoxazoles varied depending on the species and on the chemical structure between 25 and 100 mg/kg p ... | 1988 | 3387822 |
| dipetalonema viteae in mastomys natalensis: effect of pregnancy and lactation on establishment and course of infection. | the susceptibility of hosts to filarial infection during pregnancy and lactation was studied using dipetalonema viteae in mastomys natalensis as working model. though no difference in prepatency could be observed yet significantly higher density of microfilaraemia than controls was detected in both pregnant and lactating groups. extended duration of patency was also found in both pregnant and lactating animals. on autopsy, animals exposed at the time of pregnancy or lactation revealed significan ... | 1988 | 3387824 |
| response of dipetalonema viteae in mastomys natalensis to some known antifilarials. | 1988 | 3403011 | |
| an analysis of stereotyped behaviour in mastomys natalensis. | the stereotyped behaviour was analysed in mastomys natalensis, a species of desert rat recently introduced in laboratory practice. the components of stereotyped behaviour were similar to rat characterised by repetitive sniffing, rearing, licking, head movements and biting. apomorphine (0.5-2.0 mg/kg), amphetamine (2.5-10 mg/kg), methylphenidate (10-30 mg/kg) and adamantanamine (10-50 mg/kg) administered intraperitoneally, induced stereotyped behaviour in dose-dependent manner. positive response ... | 1988 | 3412495 |
| brugia malayi microfilariae share epitopes with aedes aegypti. | shared antigens between brugia malayi and aedes aegypti were studied. the experiments carried out with sera from infected mastomys natalensis indicated that an immunological response against a. aegypti antigens (mr 185, 35, 32 kda) appeared often when animals became microfilaraemic and increased progressively in intensity during the time-course of infection. sera of animals immunized with b. malayi reacted with the crude extract of mosquitoes and conversely, antibodies from animals immunized wit ... | 1988 | 2462205 |
| effect of cyclosporin a and some derivatives in litomosoides carinii-infected mastomys natalensis. | litomosoides carinii-infected mastomys natalensis were treated 85 days post infection with cyclosporin a (cya) or 8 derivatives with different immunosuppressive capacities. cya (oral doses of 5 x 25 mg/kg, 5 x 50 mg/kg, 5 x 80 mg/kg on consecutive days) reduced parasitaemia levels in a dose dependent way, beginning 3 weeks after first drug administration. using 5 x 50 and 5 x 80 mg/kg animals were free from circulating microfilariae on the day of necropsy (day 56). derivatives were administered ... | 1987 | 3437108 |
| detection of circulating and urinary antigens in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. | the time-course of the detection of circulating and urinary filarial antigens was followed with a 2s-irma assay, using a mouse monoclonal antibody raised against brugia malayi larvae, in mastomys natalensis experimentally infected with brugia malayi, brugia pahangi, or litomosoides carinii. in the prepatent phase of the infections, filarial antigen was detected 4-7 weeks before microfilariae appeared in the peripheral blood. moreover, the sensitivity of the test was greater with urine than with ... | 1987 | 3438300 |
| studies on the comparative gametocytaemia of p. berghei (nk 65) in male and female mastomys natalensis. | 1987 | 3326752 | |
| dipetalonema viteae infection in three species of rodents: species specific patterns of the antibody response. | groups of jirds (meriones unguiculatus), multimammate rats (mastomys natalensis) and golden hamsters (mesocricetus auratus) were infected with third stage larvae (l3) of dipetaloneam viteae and the course of infection was followed until 20 weeks post infection. worm growth was best and microfilaraemia was high and long lasting in jirds and in multimammate rats, whereas golden hamsters were poor hosts as measured by these parameters. the igg and igm antibody responses of the species were compared ... | 1987 | 3550602 |
| lysosomal enzymes in mastomys natalensis during different stages of infection with brugia malayi. | 1987 | 3583352 | |
| reaginic and homocytotropic igg antibody response of mastomys natalensis in experimental infections of filarial parasites (litomosoides carinii, dipetalonema viteae, brugia malayi, b. pahangi). | reaginic and homocytotropic igg antibodies in sera using passive cutaneous anaphylaxis (pca) test and antigen from litomosoides carinii were followed in mastomys natalensis, infected with l. carinii, dipetalonema viteae, brugia malayi or b. pahangi. groups of animals with infections of various ages so as to cover a total infection period of up to 300 to 420 days post-infection (p.i.), depending on the species of parasites, were bled at 1- to 3-week intervals over periods of 50-112 days. in addit ... | 1987 | 3588585 |
| histopathological and electron microscopical studies in litomosoides carinii infected mastomys natalensis. | 1987 | 3591109 | |
| morphological alterations in female litomosoides carinii after treatment with two benzthiazole derivatives in vivo. | multimammate rats (mastomys natalensis) infected with litomosoides carinii were treated 65 days after infection with a single oral dose of 50 mg/kg of cgp 20308 or cgp 20376 (ciba geigy limited, basel). autopsies were performed between 1 and 28 days after treatment. the numbers of worms and the numbers and condition of intrauterine developmental stages in the females were determined. other female filariae were investigated by transmission electron microscopy (tem). female filariae were observed ... | 1987 | 3602833 |
| effect of ivermectin in dipetalonema viteae and litomosoides carinii infections of mastomys natalensis. | in d. viteae infected m. natalensis oral or subcutaneous (s.c.) treatment with ivermectin on 5 consecutive days with at least 0.05 mg/kg and single dose treatment with 0.1 mg/kg caused a 100% reduction of microfilaraemia throughout the investigation period of 42 days. using lower doses (lowest dose used 5 x 0.003 mg/kg) animals were free from circulating microfilariae at least until day 7. the drug was active against adult worms. treatment with doses of 5 x 0.2 mg/kg and above resulted in 81-93% ... | 1987 | 3629133 |
| effect of ivermectin on serum dependent cellular interactions to dipetalonema viteae microfilariae. | the effects of ivermectin (iv) on the filarial infection has been investigated using dipetalonema viteae--mastomys natalensis model system. in vitro, iv (3 micrograms/ml) had no effect on the microfilariae (mf) in the presence or absence of serum from normal or infected mastomys (nms, ims). however, the sera promoted cell-mediated cytotoxicity with macrophages or eosinophils to the mf when iv was added at 3 ng/ml. sera isolated from normal or infected mastomys after subcutaneous treatment with i ... | 1987 | 3629134 |
| homocytotropic antibodies of the multimammate rat, mastomys natalensis. demonstration and characterization of 2 types classified as ige and igg3. | 1987 | 3673297 | |
| stage-specific homocytotropic antibody response of mastomys natalensis to dipetalonema viteae infection. | 1987 | 2884834 | |
| a prospective study of the epidemiology and ecology of lassa fever. | in studies of lassa fever in sierra leone, the prevalence of human antibody to lassa virus ranged from 8% to 52%. mastomys natalensis, the reservoir of lassa virus, constituted 50%-60% of the rodents captured in houses but only 10%-20% of those captured in surrounding agriculture and bush areas (chi 2 = 90.2, p less than 10(-6), df = 1), a finding suggesting that houses are the most-important location for transmission of lassa virus. viral infection of mastomys from houses ranged from 0% to 80%. ... | 1987 | 3805771 |
| experimental infections of the multimammate rat (mastomys natalensis) with leishmania donovani and leishmania major. | the susceptibility of the multimammate rat, mastomys natalensis, to experimental infections with leishmania donovani and l. major was examined. inoculations of l. major promastigotes into the skin resulted in nonulcerating lesions in which parasites could be detected for more than 30 weeks later. intravenous inoculations of l. donovani promastigotes produced visceral infections characterized by a continuing increase in splenic parasite burdens and liver parasite burdens which peaked during the f ... | 1987 | 3826485 |
| comparative morphology of the prostate in adult male and female praomys (mastomys) natalensis studied with electron microscopy. | comparative study at the cellular and subcellular levels of the adult male and female prostates of a unique species of rodent--praomys (mastomys) natalensis--was made. the female possesses a well-developed prostate throughout life that may be considered homologous to the ventral prostatic lobe in the male praomys. histologically, only small differences exist to indicate that the female prostate is somewhat less active than the male (less secretion and the presence of fewer supranuclear light are ... | 1987 | 3560297 |
| histochemical and proliferative changes preceding the onset of spontaneous gastric adenocarcinoma in mastomys natalensis. | the histochemical and proliferative changes preceding spontaneously developing gastric adenocarcinoma were examined in mastomys natalensis. the stomachs of 86 inbred animals from the dwz strain were examined between 1 and 24 months of age. two thirds of the animals had a small solitary ulcer in the middle of the lesser curvature which was observed by the first month of age. with increasing age, more and more dysplastic glands invading the submucosa were seen around the ulcer and eventually adeno ... | 1987 | 3113067 |
| ontogenic studies on biogenic amines in heart, lung and adrenal glands of mastomys natalensis. | 1986 | 3596628 | |
| ontogenic studies on brain biogenic amines in mastomys natalensis. | 1986 | 3781597 |