Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| trichomonas vaginalis: clinical relevance, pathogenicity and diagnosis. | trichomonas vaginalis is the etiological agent of trichomoniasis, the most prevalent non-viral sexually transmitted disease worldwide. trichomoniasis is a widespread, global health concern and occurring at an increasing rate. infections of the female genital tract can cause a range of symptoms, including vaginitis and cervicitis, while infections in males are generally asymptomatic. the relatively mild symptoms, and lack of evidence for any serious sequelae, have historically led to this disease ... | 2016 | 25383648 |
| a pilot study on trichomonas vaginalis in women with recurrent urinary tract infections. | trichomoniasis and recurrent urinary tract infections (utis) shared similar risk factors, age distribution and overlapping symptoms. the aim of this study was to determine the prevalence of trichomonas vaginalis (tv) in women with recurrent utis, attending a urology clinic in a medical center, in order to inform screening and treatment policies. | 2016 | 27793272 |
| trichomoniasis immunity and the involvement of the purinergic signaling. | innate and adaptive immunity play a significant role in trichomoniasis, the most common non-viral sexually transmitted disease worldwide. in the urogenital tract, innate immunity is accomplished by a defense physical barrier constituted by epithelial cells, mucus, and acidic ph. during infection, immune cells, antimicrobial peptides, cytokines, chemokines, and adaptive immunity evolve in the reproductive tract, and a proinflammatory response is generated to eliminate the invading extracellular p ... | 2016 | 27793265 |
| signalling pathways associated with il-6 production and epithelial-mesenchymal transition induction in prostate epithelial cells stimulated with trichomonas vaginalis. | trichomonas vaginalis (tv) has been found in patient tissue of benign prostatic hyperplasia (bph), and suggested to cause chronic prostatitis. il-6 is known as one of the important factors of chronic inflammation in prostate cancer. patients with chronic prostatitis/chronic pelvic pain syndrome (cp/cpps) had higher levels of il-6 in seminal plasma. furthermore, inflammatory conditions induced by pathogen infections have been shown to promote epithelial-mesenchymal transition (emt). here, we inve ... | 2016 | 27543848 |
| trichomonas vaginalis infection in nigerian pregnant women and risk factors associated with sexually transmitted infections. | trichomoniasis poses a public health threat to pregnant women and neonatal health. this study evaluated trichomonas vaginalis and other common sexually transmitted infections (stis) status in pregnant women, and risk factors associated with them. the study was cross-sectional and descriptive and a total of 198 pregnant women were recruited for t. vaginalis screening by microscopic examination. questionnaires were also administered to 108 pregnant women to access information related to socio-demo ... | 2016 | 26438604 |
| multilocus sequence typing of trichomonas vaginalis clinical samples from amsterdam, the netherlands. | in this cross-sectional epidemiological study we aimed to identify molecular profiles for trichomonas vaginalis and to determine how these molecular profiles were related to patient demographic and clinical characteristics. | 2016 | 27737887 |
| challenges and persistent questions in treatment of trichomoniasis. | trichomoniasis is a sexually transmitted disease (std) caused by infection with the protozoan parasite trichomonas vaginalis. it is considered the most prevalent non-viral sexually transmitted disease worldwide. recently, the infection has been associated with adverse outcomes of pregnancy and increased risks of hiv acquisition and transmission, besides the association with cervical and prostate cancers. the consequences of trichomoniasis are likely much greater than previously recognized, both ... | 2016 | 27697044 |
| trichomonas vaginalis infection is uncommon in the british general population: implications for clinical testing and public health screening. | variable use of new molecular assays, asymptomatic infections and a lack of population data mean that the population burden of trichomonas vaginalis is uncertain. we investigated the age-specific prevalence of t. vaginalis within the sexually active british general population to inform testing strategies. | 2016 | 27686884 |
| anti-trichomonas vaginalis activity of betulinic acid derivatives. | caused by trichomonas vaginalis, trichomoniasis is the most common non-viral std worldwide. currently, metronidazole and tinidazole are the only drugs approved for treatment of the condition. however, problems such as metronidazole-resistant t. vaginalis isolates and allergic reactions have been reported. based on data previously published by our group, structural changes in betulinic acid (1) were performed, generating three new compounds that were tested for in vitro anti-t.vaginalis activity ... | 2016 | 27685791 |
| trichomonas vaginalis prevalence and risk factors for women in southern brazil. | trichomonas vaginalis infections have been associated with other diseases so that epidemiological studies of the parasite are important and help to prevent the spread of the disease. this study aimed to determine the prevalence of t. vaginalis in female patients of 19 counties in southwestern rio grande do sul, brazil. for diagnosis, was used direct examination, followed by applying a socio-epidemiological questionnaire. we analyzed 300 women and 9% were infected by trichomonas vaginalis. the hi ... | 2016 | 27680166 |
| technical note: preservation of trichomonas vaginalis viability in urine for laboratorial diagnosis by the wet mount examination. | this study compared preservative solutions at different temperatures aiming to improve the wet mount for trichomoniasis diagnosis. the glucose-saline ph6.0 solution preserved the trophozoites up to 6h. the urine samples preservation is crucial for diagnosis and we suggest this solution as part of the clinical laboratorial routine. | 2016 | 27666653 |
| 2-methyl-4/5-nitroimidazole derivatives potentiated against sexually transmitted trichomonas: design, synthesis, biology and 3d-qsar study. | trichomoniasis is the most prevalent, non-viral sexually transmitted diseases (std) caused by amitochondriate protozoan trichomonas vaginalis. increased resistance of t. vaginalis to the marketed drug metronidazole necessitates the development of newer chemical entities. a library of sixty 2-methyl-4/5-nitroimidazole derivatives was synthesized via nucleophilic ring opening reaction of epoxide and the efficacies against drug-susceptible and -resistant trichomonas vaginalis were evaluated. all th ... | 2016 | 27643640 |
| auranofin inactivates trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo. | trichomoniasis, caused by the protozoan parasite trichomonas vaginalis, is the most common, non-viral, sexually transmitted infection in the world, but only two closely related nitro drugs are approved for its treatment. new antimicrobials against trichomoniasis remain an urgent need. several organic gold compounds were tested for activity against t. vaginalis thioredoxin reductase (trxr) in cell-free systems as well as for activity against different trichomonads in vitro and in a murine infecti ... | 2016 | 27839893 |
| comparative protein structure modeling using modeller. | comparative protein structure modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). the prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. this unit describes how to calculate comparative models using the program modeller and how to use the modbase database of such models, and discusses all four steps of comparativ ... | 2016 | 27801516 |
| benefits of cervical cancer screening by liquid-based cytology as part of routine antenatal assessment. | to determine the prevalence of abnormal cervical cytology, as diagnosed using a liquid-based cytology technique, in pregnant women attending the antenatal care (anc) clinic at siriraj hospital. | 2016 | 27797261 |
| epidemiology of trichomoniasis in south korea and increasing trend in incidence, health insurance review and assessment 2009-2014. | trichomoniasis, which is caused by trichomonas vaginalis, is one of the most common non-viral sexually transmitted infections; however, limited population-based data are available that describe patterns and trends of the disease. we summarized insurance claims of trichomoniasis cases reported during 2009-2014 to south korea health insurance review and assessment service. the average annual incidence in south korea was 276.8 persons per 100,000 population, and a substantial sex-associated variati ... | 2016 | 27936227 |
| antiprotozoal effects of the tomato tetrasaccharide glycoalkaloid tomatine and the aglycone tomatidine on mucosal trichomonads. | the present study investigated the inhibitory effects of the commercial tetrasaccharide tomato glycoalkaloid tomatine and the aglycone tomatidine on three mucosal pathogenic protozoa that are reported to infect humans, cattle, and cats, respectively: trichomonas vaginalis strain g3, tritrichomonas foetus strain d1, and tritrichomonas foetus strain c1. a preliminary screen showed that tomatine at 100 μm concentration completely inhibited the growth of all three trichomonads. in contrast, the inhi ... | 2016 | 27934291 |
| ginger (zingiber officinale) induces apoptosis in trichomonas vaginalis in vitro. | trichomoniasis is the most common sexually transmitted protozoan diseases in the worldwide. metronidazole is the choice drug for trichomoniasis treatment, however, metronidazole resistant trichomonas vaginalis (t.vaginalis) has been reported. natural products are the source of most new drugs, and zingiber officinale (ginger) is widely used ingredient in the traditional medicine. | 2016 | 27981254 |
| prevalence and associated factors of genital and sexually transmitted infections in married women of iran. | this study aimed to determine the prevalence of genital and sexually transmitted infections and its related factors in married women in iran. | 2016 | 27974960 |
| [investigation of the prevalence of trichomonas vaginalis among female syrian refugees with the complaints of vaginitis aged between 15-49 years]. | since the syrian civil war began in 2011, most of the syrian refugees have immigrated to turkey due to its open gate policy and the width of the border. by the end of 2015, it was estimated that there were 2.5 million syrian refugees in turkey. many of the syrian refugees live in sanliurfa due to its location on the border with syria. trichomonas vaginalis, apart from viral agents is the most common parasite among sexually transmitted infection agents. the aim of this study was to determine the ... | 2016 | 28124964 |
| can trichomoniasis cause pharyngitis? a case report. | we report on a heterosexual male with sore throat diagnosed as oral trichomoniasis vaginalis. | 2016 | 28228954 |
| trichomoniasis - are we giving the deserved attention to the most common non-viral sexually transmitted disease worldwide? | trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted disease (std) in the world. transmission: trichomoniasis is transmitted by sexual intercourse and transmission via fomites is rare. epidemiology, incidence and prevalence: the who estimates an incidence of 276 million new cases each year and prevalence of 187 million of infected individuals. however, the infection is not notifiable. pathology/symptomatology: the t. vaginalis infection r ... | 2016 | 28357378 |
| urinary infection due to balantioides coli: a rare accidental zoonotic disease in an addicted and diabetic young female in iran. | balantiosis, a rare zoonotic infection resulting in dysentery, is caused by the large ciliated protozoan parasite balantioides coli. humans acquire this organism via the faecal-oral route. very rarely, extraintestinal infections can occur in the urinary tract system. there are very few case reports of urinary balantiosis in humans. | 2016 | 28348744 |
| activity of pyrrolizidine alkaloids against biofilm formation and trichomonas vaginalis. | crotalaria genus belongs to the subfamily papilionoideae comprising about 600 species spread throughout tropical, neotropical and subtropical regions. in this study, seeds of crolatalaria pallida were used to the isolation of usaramine, a pyrrolizidine alkaloid. thus, pseudomonas aeruginosa and staphylococcus epidermidis were utilized as strains to test some activities of this alkaloid, such as antibiofilm and antibacterial. meanwhile, monocrotaline obtained from crotalaria retusa seeds, was use ... | 2016 | 27399809 |
| [investigation of in vitro metronidazole resistance in the clinical isolates of trichomonas vaginalis]. | trichomonas vaginalis, a flagellated, urogenital anaerobic protozoon is reported as an important cause of vaginitis with a global distribution. although metronidazole is the primary choice of drug for the treatment of trichomoniasis, the presence of resistant isolates from many different countries highlights the need of novel drugs for the treatment. many studies from turkey mostly dealing with the in vitro effects of compounds and natural products against t.vaginalis have been reported, however ... | 2016 | 28124960 |
| vulvovaginite : dépistage et prise en charge de la trichomonase, de la candidose vulvovaginale et de la vaginose bactérienne. | analyser les données probantes et formuler des recommandations quant au dépistage et à la prise en charge de la candidose vulvovaginale, de la trichomonase et de la vaginose bactérienne. | 2016 | 28063567 |
| the cytoskeleton of parabasalian parasites comprises proteins that share properties common to intermediate filament proteins. | certain protist lineages bear cytoskeletal structures that are germane to them and define their individual group. trichomonadida are excavate parasites united by a unique cytoskeletal framework, which includes tubulin-based structures such as the pelta and axostyle, but also other filaments such as the striated costa whose protein composition remains unknown. we determined the proteome of the detergent-resistant cytoskeleton of tetratrichomonas gallinarum. 203 proteins with homology to trichomon ... | 2016 | 27744090 |
| [in vitro susceptibility of trichomonas vaginalis to metronidazole, ornidazole and proton pump inhibitors pantoprazole and esomeprazole]. | the current treatment of trichomoniasis is based on the use of 5-nitroimidazole derivatives. although metronidazole is reliable, inexpensive and highly effective against anaerobic microorganisms and protozoa, the development of metronidazole-resistant t.vaginalis strains pose to an increasing problem. nitroimidazoles are compounds having azomycin (2-nitroimidazole) chemical structure and are obtained from streptomyces strains. benzimidazole, which is found in the structure of proton pump inhibit ... | 2016 | 27058337 |
| responding to a zoonotic emergency with multi-omics research: pentatrichomonas hominis hydrogenosomal protein characterization with use of rna sequencing and proteomics. | pentatrichomonas hominis is an anaerobic flagellated protist that colonizes the large intestine of a number of mammals, including cats, dogs, nonhuman primates, and humans. the wide host range of this organism is alarming and suggests a rising zoonotic emergency. however, knowledge on in-depth biology of this protist is still limited. similar to the human pathogen, trichomonas vaginalis, p. hominis possesses hydrogenosomes instead of mitochondria. studies in t. vaginalis indicated that hydrogeno ... | 2016 | 27828770 |
| mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics. | a series of mono- and multimeric polyamine-containing ferrocenyl complexes containing a quinoline motif were prepared. the complexes were characterised by standard techniques. the molecular structure of the monomeric salicylaldimine derivative was elucidated using single crystal x-ray diffraction and was consistent with the proposed structure. the antiplasmodial activity of the compounds were evaluated in vitro against both the nf54 (chloroquine-sensitive) and k1 (chloroquine-resistant) strains ... | 2016 | 27485032 |
| leukocyte lysis and cytokine induction by the human sexually transmitted parasite trichomonas vaginalis. | trichomonas vaginalis (tv) is an extracellular protozoan parasite that causes the most common non-viral sexually transmitted infection: trichomoniasis. while acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased hiv susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. heightened inflammation resulting from tv infection could account for these complication ... | 2016 | 27529696 |
| symbiotic association with mycoplasma hominis can influence growth rate, atp production, cytolysis and inflammatory response of trichomonas vaginalis. | the symbiosis between the parasitic protist trichomonas vaginalis and the opportunistic bacterium mycoplasma hominis is the only one currently described involving two obligate human mucosal symbionts with pathogenic capabilities that can cause independent diseases in the same anatomical site: the lower urogenital tract. although several aspects of this intriguing microbial partnership have been investigated, many questions on the influence of this symbiosis on the parasite pathobiology still rem ... | 2016 | 27379081 |
| [usefulness of conventional polymerase chain reaction for the detection of mycoplasma hominis, ureaplasma spp. and trichomonas vaginalis in female outpatient's genital samples]. | trichomonas vaginalis, mycoplasma hominis and ureaplasma spp. are microorganisms responsible for genitourinary and pregnancy pathologies. nucleic acid amplification methods have shown several advantages, but have not been widely studied for the detection of these microorganisms. | 2016 | 26965874 |
| sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in jalisco, mexico. | to determine the frequency of nine sexually transmitted pathogens, coinfections and risk factors in patients attending obstetrics and gynecology clinics in jalisco, mexico. | 2016 | 27599076 |
| antiprotozoal screening of the cuban native plant scutellaria havanensis. | scutellaria havanensis jacq. (lamiaceae) is a native medicinal herb with a history of use in cuba. | 2016 | 27564587 |
| in vitro effect of octenidine dihydrochloride against trichomonas vaginalis. | trichomoniasis is the most common non-viral sexually transmitted disease. it is associated with a wide spectrum of complications, including infertility and increased susceptibility to human immunodeficiency virus (hiv). a rising number of reports of trichomonas vaginalis strains resistant to metronidazole has driven the search for new compounds. in the present study, the in vitro effects of the common antiseptic octenidine dihydrochloride against t. vaginalis were tested on metronidazole-resista ... | 2016 | 26899578 |
| perturbing purinergic signaling: a pathogen's guidebook to counteracting inflammatory responses. | in this issue of the biomedical journal, we learn how bacteria and parasites alike counteract inflammatory signaling by manipulating purinergic signaling. we also focus on an original article shedding light on the role of an epstein-barr virus encoded gene in metastasis in nasopharyngeal carcinoma. finally, we learn about a possible link between trichomonas vaginalis and recurrent urinary tract infection. | 2016 | 27793264 |
| the incidence of trichomonas vaginalis infection in women attending nine sexually transmitted diseases clinics in the usa. | trichomoniasis (tv) is associated with an increased risk of acquisition of sexually transmitted diseases (stds) and hiv. the purpose of this study is to evaluate factors associated with incidence tv among female std clinic attendees in the usa. | 2016 | 26071390 |
| associations between vaginal infections and potential high-risk and high-risk human papillomavirus genotypes in female sex workers in western kenya. | infection with and persistence of high-risk human papillomavirus (hr hpv) are the strongest risk factors for cervical cancer. little is known about the prevalence and role of concurrent sexually transmitted infections (stis) found in hpv-infected female sex workers (fsw) in africa. this study purports to test our a priori hypotheses that stis are associated with genotypes pertaining to the α-group species 9. the objectives were to determine the prevalence of bacterial vaginosis (bv), trichomonas ... | 2016 | 27836494 |
| reproductive tract infections and premalignant lesions of cervix: evidence from women presenting at the cancer detection centre of the indian cancer society, delhi, 2000-2012. | burden of cervical cancer (cc) is highest for women in low- and middle-income countries (lmics). human papillomavirus (hpv) is implicated as the necessary cause of cc although a number of other factors aid the long process of cc development. one among them is the presence of reproductive tract infections (rtis). this study investigated the associations between rtis and cc from india. | 2016 | 27651644 |
| association of genital infections other than human papillomavirus with pre-invasive and invasive cervical neoplasia. | human papillomavirus (hpv) is a well-established causative agent of malignancy of the female genital tract and a common sexually transmitted infection. the probable co-factors that prevent spontaneous clearance of hpv and progression to neoplasia are genital tract infections from organisms like chlamydia, trichomonas vaginalis etc, smoking, nutritional deficiencies and multiparity. inflammatory conditions can lead to pre-neoplastic manifestations in the cervical epithelium; however their specifi ... | 2016 | 27042571 |
| bacterial vaginosis, aerobic vaginitis, vaginal inflammation and major pap smear abnormalities. | the purpose of this investigation was to evaluate the impact of the vaginal milieu on the presence of abnormal pap smears and a positive human papilloma virus (hpv) test. a cross-sectional study was conducted between june 2014 and may 2015, evaluating the vaginal discharge by fresh wet mount microscopy and comparing these data with pap smear findings. wet mount slides were scored for bacterial vaginosis (bv), aerobic vaginitis (av), presence of candida and trichomonas vaginalis. cytologic evalua ... | 2016 | 26810061 |
| trichomonas vaginalis and human immunodeficiency virus coinfection among women under community supervision: a call for expanded t. vaginalis screening. | the united states has a large community supervision population, a growing number of whom are women. trichomonas vaginalis infection is strongly associated with an increased risk of human immunodeficiency virus (hiv) acquisition and transmission, particularly among women, but there is a paucity of research on hiv and t. vaginalis co-infection among women under community supervision. | 2016 | 27631355 |
| trichomonas vaginalis nucleic acid amplification testing at an urban hiv clinic. | trichomonas vaginalis is the most common nonviral sexually transmitted infection. t. vaginalis nucleic acid amplification testing (naat) recently became available at the university of alabama at birmingham human immunodeficiency virus (hiv) clinic. the objective of this study was to determine the uptake of t. vaginalis naat testing among clinic providers during the first year of test availability in addition to t. vaginalis prevalence and predictors based on naat results. | 2016 | 27419815 |
| synthesis, screening and in silico simulations of anti-parasitic propamidine/benzimidazole derivatives. | propamidine, an antiseptic aromatic diamidine is a toxic compound with potential use as antiprotozoal drug. on the other hand, benzimidazole derivatives have shown excellent antiparasitic effects. we designed hybrid molecules between propamidine and benzimidazole in order to retain the antiprotozoal action, but decreasing the toxic effect of the molecule. objetive: design and prepare 12 hybrids from propamidine and benzimidazole for testing their antiparasitic effect over three protozoa: giardia ... | 2016 | 27527618 |
| analysis of the vaginal microbiome by next-generation sequencing and evaluation of its performance as a clinical diagnostic tool in vaginitis. | next-generation sequencing (ngs) can detect many more microorganisms of a microbiome than traditional methods. this study aimed to analyze the vaginal microbiomes of korean women by using ngs that included bacteria and other microorganisms. the ngs results were compared with the results of other assays, and ngs was evaluated for its feasibility for predicting vaginitis. | 2016 | 27374709 |
| [vaginal infections in pregnant women at the regional hospital of sokode (togo) in 2010 and 2011]. | the aim of this study was to evaluate the prevalence of the major microorganisms causing vaginal infections in pregnant women consulting at the regional hospital of sokodé and to assess their sensitivity to antibiotics. | 2016 | 23692693 |
| [characteristics of vaginal ecosystem in endocervicitis chlamydialis]. | the study aims: 1. to analyze and study the specifics of microbiocenoses of exocervix at endocervicitis chlamydialis, to differentiate the spectrum of stimuli, and establish the leading role of chl. trachomatis in the genesis of this process. 2. to determine the leading role of the method of direct (bed-side) microscopy for early and rapid diagnosis of cervicitis and conducting etiotropic therapy. we determined the incidence of endocervicitis chlamydialis, with cause chl. trachomatis-45.1%, (319 ... | 2016 | 27514125 |
| structure of methionine γ-lyase from clostridium sporogenes. | methionine γ-lyase (mgl) is a pyridoxal 5'-phosphate-dependent enzyme that catalyzes the γ-elimination reaction of l-methionine. the enzyme is a promising target for therapeutic intervention in some anaerobic pathogens and has attracted interest as a potential cancer treatment. the crystal structure of mgl from clostridium sporogenes has been determined at 2.37 å resolution. the fold of the protein is similar to those of homologous enzymes from citrobacter freundii, entamoeba histolytica, pseudo ... | 2016 | 26750487 |
| nitroimidazole carboxamides as antiparasitic agents targeting giardia lamblia, entamoeba histolytica and trichomonas vaginalis. | diarrhoeal diseases caused by the intestinal parasites giardia lamblia and entamoeba histolytica constitute a major global health burden. nitroimidazoles are first-line drugs for the treatment of giardiasis and amebiasis, with metronidazole 1 being the most commonly used drug worldwide. however, treatment failures in giardiasis occur in up to 20% of cases and development of resistance to metronidazole is of concern. we have re-examined 'old' nitroimidazoles as a foundation for the systematic dev ... | 2016 | 27236016 |
| [detection of echinococcus granulosus and echinococcus multilocularis in cyst samples using a novel single tube multiplex real-time polymerase chain reaction]. | cystic echinococcosis (ce) and alveolar echinococcosis (ae) caused by echinococcus granulosus and echinococcus multilocularis, respectively, are important helminthic diseases worldwide as well as in our country. epidemiological studies conducted in turkey showed that the prevalence of ce is 291-585/100.000. it has also been showed that the seroprevalence of ae is 3.5%. for the diagnosis of ce and ae, radiological (ultrasonography, computed tomography, magnetic resonance) and serological methods, ... | 2016 | 27175499 |
| drug repurposing: mining protozoan proteomes for targets of known bioactive compounds. | to identify potential opportunities for drug repurposing by developing an automated approach to pre-screen the predicted proteomes of any organism against databases of known drug targets using only freely available resources. | 2016 | 23757409 |
| multilocus sequence typing of dientamoeba fragilis identified a major clone with widespread geographical distribution. | the flagellated protozoan dientamoeba fragilis is often detected in humans with gastrointestinal symptoms, but it is also commonly found in healthy subjects. as for other intestinal protozoa, the hypothesis that genetically dissimilar parasite isolates differ in their ability to cause symptoms has also been raised for d. fragilis. to date, only two d. fragilis genotypes (1 and 2) have been described, of which genotype 1 largely predominates worldwide. however, very few markers are available for ... | 2016 | 27555056 |
| human parasitic protozoan infection to infertility: a systematic review. | protozoan parasitic diseases are endemic in many countries worldwide, especially in developing countries, where infertility is a major burden. it has been reported that such infections may cause infertility through impairment in male and female reproductive systems. we searched medline, pubmed, and scopus databases and google scholar to identify the potentially relevant studies on protozoan parasitic infections and their implications in human and animal model infertility. literature described th ... | 2016 | 26573517 |
| structure-based design of inhibitors of the crucial cysteine biosynthetic pathway enzyme o-acetyl serine sulfhydrylase. | the cysteine biosynthetic pathway is of fundamental importance for the growth, survival, and pathogenicity of the many pathogens. this pathway is present in many species but is absent in mammals. the ability of pathogens to counteract the oxidative defences of a host is critical for the survival of these pathogens during their long latent phases, especially in anaerobic pathogens such as entamoeba histolytica, leishmania donovani, trichomonas vaginalis, and salmonella typhimurium. all of these o ... | 2016 | 26303427 |
| comparison of substance use typologies as predictors of sexual risk outcomes in african american adolescent females. | african american female adolescents have a disproportionate risk of sexually transmitted infections (stis) and other adverse sexual health outcomes. both alcohol and marijuana use have been shown to predict sexual risk among young african american women. however, no studies have attempted to differentiate alcohol and marijuana typologies use as predictors of sexual risk outcomes exclusively among adolescents who use these substances. this study compared recent alcohol and/or marijuana use as pre ... | 2016 | 25929200 |
| sexually transmitted diseases: epidemiological and clinical aspects in adults. | sexually transmitted diseases (stds) are the first 10 causes of unpleased diseases in young adult women in the world. the concept of stds includes a series of syndromes caused by pathogens that can be acquired by sexual intercourse or sexual activity.adolescents and young adults are responsible for only 25% of the sexually active population and they represent almost 50% of all newly acquired stds.in this way, we evaluated the epidemiological and clinical aspects of most relevant pathogens as nei ... | 2016 | 25532465 |
| prevalence of microorganisms co-infections in human papillomaviruses infected women in northern china. | due to scarce data on the prevalence of genital microorganism infections among individuals with human papillomavirus (hpv) infections, the present study aimed to evaluate microorganism co-infections and associated risk factors in hpv-infected women in northern china. | 2016 | 26280325 |
| large two-centre study into the prevalence of mycoplasma genitalium and trichomonas vaginalis in the netherlands. | mycoplasma genitalium and trichomonas vaginalis are common sexually transmitted infections (stis). in the netherlands, testing for m. genitalium and t. vaginalis is not recommended for first-line sti screening. recent reports about the increasing antimicrobial resistance in m. genitalium raise concern about the adequacy of current empirical treatment regimens. it is necessary to have insight in the prevalence of m. genitalium and t. vaginalis in order to evaluate current first-line sti screening ... | 2016 | 26199286 |
| human papillomavirus positivity in women undergoing intrauterine insemination has a negative effect on pregnancy rates. | sexually transmitted infections are a major cause of infertility. human papillomavirus (hpv) infection is one of the most common viral infections of the female genital tract. only a limited number of studies have investigated the influence of hpv on fertility and its impact remains controversial. | 2016 | 26160018 |
| cervicitis aetiology and case definition: a study in australian women attending sexually transmitted infection clinics. | studies examining cervicitis aetiology and prevalence lack comparability due to varying criteria for cervicitis. we aimed to outline cervicitis associations and suggest a best case definition. | 2016 | 26586777 |
| pelvic inflammatory disease associated with chlamydia trachomatis but not mycoplasma genitalium in new zealand. | background there is a paucity of studies looking at associations between mycoplasma genitalium and pelvic inflammatory disease (pid). the objectives of this study were to estimate the prevalence of m. genitalium in women attending a sexual health service in new zealand and secondly to examine for an association of m. genitalium with pid. | 2016 | 26547264 |
| prevalent bacterial vaginosis infection - a risk factor for incident sexually transmitted infections in women in durban, south africa. | the association between bacterial vaginosis (bv) and incident sexually transmitted infections (stis) in a cohort of high-risk women from durban, south africa was investigated in this study. we undertook a secondary analysis of the methods for improving reproductive health in africa trial that assessed effectiveness of the latex diaphragm and lubricant gel on hiv prevention among women. during study visits, urine specimens were collected for testing for neisseria gonorrhoeae, chlamydia trachomati ... | 2016 | 26538552 |
| multiplex pcr testing for nine different sexually transmitted infections. | current sexually transmitted infection (sti) testing is not optimal due to delays in reporting or missed diagnoses due to a lack of comprehensive testing. the filmarray® (biofire diagnostics, llc, salt lake city, utah) is a user-friendly, fully automated, multiplex pcr system that is being developed for rapid point-of-care use. a research-use-only sti panel including multiple pcr primer sets for each organism was designed to detect chlamydia trachomatis, neisseria gonorrhoeae, treponema pallidum ... | 2016 | 26538551 |
| a scottish multi-centre service evaluation examining the prevalence and diagnosis of trichomonas vaginalis in symptomatic women attending sexual health clinics. | trichomoniasis caused by the protozoan parasite trichomonas vaginalis (tv) is one of the most commonly occurring sexually transmitted infections of non-viral origin. this study examines the prevalence of tv infection amongst consenting symptomatic women attending three of the largest sexual health clinics in scotland, united kingdom. in addition, an evaluation of three testing methods to identify tv from vaginal fluid was performed involving the commercial hologic aptima tv transcription-mediate ... | 2016 | 26429895 |
| trichomonas vaginalis and mycoplasma genitalium: age-specific prevalence and disease burden in men attending a sexually transmitted infections clinic in amsterdam, the netherlands. | men are not routinely tested for trichomonas vaginalis (tv) and mycoplasma genitalium (mg) in the netherlands and, therefore, very few studies have looked into their prevalence and/or role in urogenital complaints in the dutch male population. | 2016 | 26283740 |
| prevalence and correlates of trichomonas vaginalis infection among female sex workers in a city in yunnan province, china. | sexual transmission is the fastest growing route of hiv transmission in china, and trichomonas vaginalis(tv) can facilitate hiv transmission and acquisition. our goal was to determine the prevalence and correlates of tv infection among female sex workers (fsws). this cross-sectional study was conducted in a city of yunnan province in southern china, with confidential face-to-face interviews and laboratory tests for tv (wet mount) and other sexually transmitted infections. a total of 734 fsws par ... | 2016 | 25957327 |
| trichomonas vaginalis infection: how significant is it in men presenting with recurrent or persistent symptoms of urethritis? | persistent or recurrent non-gonococcal urethritis has been reported to affect up to 10-20% of men attending sexual health clinics. an audit was undertaken to review the management of persistent or recurrent non-gonococcal urethritis in men presenting at whittall street clinic, birmingham, uk. detection of trichomonas vaginalis infection was with the newly-introduced nucleic acid amplification test. a total of 43 (8%) of 533 men treated for urethritis re-attended within three months with persiste ... | 2016 | 25663246 |
| 2nd bashh oxford diagnostics course, november 2015. | the second british association for sexual health and hiv oxford diagnostics course of 2015 focussed on recent challenges and emerging concepts within diagnostics and service design. in response to increasing sexually transmitted infection rates and subsequent demand on uk sexual health services, multiple approaches to improving patient flow and reducing waiting times were presented. the value of novel remote sexually transmitted infection testing was explored, with a description of the patient j ... | 2016 | 26787639 |
| combination emtricitabine and tenofovir disoproxil fumarate prevents vaginal simian/human immunodeficiency virus infection in macaques harboring chlamydia trachomatis and trichomonas vaginalis. | genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (hiv), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (prep). we investigated whether coinfection of macaques with chlamydia trachomatis and trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (ftc)/tenofovir disoproxil fumarate (tdf). macaques were exposed to simian/human immunodeficiency virus ... | 2016 | 26743846 |
| usefulness of a novel multiplex real-time pcr assay for the diagnosis of sexually-transmitted infections. | sexually transmitted infections (sti) are currently on the increase worldwide. new molecular tools have been developed in the past few years in order to improve their diagnosis. an evaluation was carried out using a new commercially available real-time pcr assay, anyplex™ ii sti-7 (seegene, seoul, korea), which detects seven major pathogens in a single reaction - chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, mycoplasma hominis, mycoplasma genitalium, ureaplasma urealyticum ... | 2016 | 26706392 |
| prevalence of chlamydia trachomatis, trichomonas vaginalis and neisseria gonorrhoeae based on data collected by a network of clinical microbiology laboratories, in italy. | bacterial and protozoal sexually transmitted infections (stis), such as chlamydia trachomatis, trichomonas vaginalis and neisseria gonorrhoeae, may cause acute symptoms, chronic infections and severe long-term complications. the complications of these infections in women include pelvic inflammatory disease, chronic pelvic pain, tubal infertility, ectopic pregnancy, and infertility. moreover, infection during pregnancy is associated with premature rupture of the membranes, low birth weight and mi ... | 2016 | 26691509 |
| urethritis-associated pathogens in urine from men with non-gonococcal urethritis: a case-control study. | the aetiology of non-gonococcal urethritis (ngu) remains unexplained in 30-40% of patients. urine samples from men attending swedish sexually transmitted disease clinics were examined by species-specific quantitative pcrs for chlamydia trachomatis, mycoplasma genitalium, trichomonas vaginalis, ureaplasma urealyticum, u. parvum, adenovirus, herpes simplex virus, neisseria meningitidis, haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae. a total of 187 men with acute ngu (s ... | 2016 | 26658669 |
| sexually transmitted infections in children as a marker of child sexual abuse and direction of future research. | this review considers recent evidence on sexually transmitted infections (stis) as a marker of child sexual abuse (csa), when diagnosed after the neonatal period. it also aims to identify if there are specific areas where additional research is required. | 2016 | 26658657 |
| pelvic examination at the 6-week postpartum visit after cesarean birth. | the objective of this study was to assess the utility of the pelvic examination at the 6-week postpartum visit after cesarean birth. | 2016 | 26971582 |
| alterations in the genital microbiota in women with spinal cord injury. | to evaluate the vaginal and cervical microbiota in women with spinal cord injury compared with mobile women. | 2016 | 26942354 |
| male non-gonococcal urethritis: from microbiological etiologies to demographic and clinical features. | to detect microorganisms responsible for male acute urethritis and to define the microbiology of non-gonococcal urethritis. | 2016 | 26845624 |
| vijana vijiweni ii: a cluster-randomized trial to evaluate the efficacy of a microfinance and peer health leadership intervention for hiv and intimate partner violence prevention among social networks of young men in dar es salaam. | intimate partner violence (ipv) and sexually transmitted infections (stis), including hiv, remain important public health problems with devastating health effects for men and women in sub-saharan africa. there have been calls to engage men in prevention efforts, however, we lack effective approaches to reach and engage them. social network approaches have demonstrated effective and sustained outcomes on changing risk behaviors in the u.s. our team has identified and engaged naturally occurring s ... | 2016 | 26842360 |
| sexually transmitted infections other than hiv/aids among women of low socio-economic class attending antenatal clinics in khartoum, sudan. | sexually transmitted infections (stis) are major health threats affecting people globally; however, the burden of stis is greatest in low-income countries. since they are physiologically more vulnerable, women are mostly affected. the risk is increased dramatically during pregnancy leading to serious health complications that may affect the newborn. underprivileged pregnant women attending antenatal clinics for routine checkups in displaced camps, a women's prison and several peripheral health c ... | 2016 | 27582306 |
| performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and mycoplasma genitalium by nucleic acid amplification assays. | men were enrolled in a study to assess the performance and acceptability of self-collected penile meatal swabs as compared to clinician-collected urethral swabs for sexually transmitted infections (stis). we expected penile-meatal swabs to perform favorably to urethral swabs for chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), and mycoplasma genitalium (mg) detection by nucleic acid amplification assays (naats). of 203 swab pairs tested; for ct, penile-meatal s ... | 2016 | 27497595 |
| evaluation of syndromic management guidelines for treatment of sexually transmitted infections in south african women. | to evaluate the performance of three different guidelines for the management of vaginal discharge syndrome (vds) for women living in a rural setting in south africa. | 2016 | 27350659 |
| prevalence of curable sexually transmitted infections in pregnant women in low- and middle-income countries from 2010 to 2015: a systematic review. | current literature comparing the prevalence rates of curable sexually transmitted infections (stis) in pregnant women in various global regions is limited. as a result, antenatal screening practices for curable stis in pregnant women, specifically treponema pallidum (syphilis), neisseria gonorrhoeae (ng), chlamydia trachomatis (ct), and trichomonas vaginalis (tv) vary around the world, differing by country and particular sti. | 2016 | 27322048 |
| prevalence and risk factors of chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis and other sexually transmissible infections among women attending antenatal clinics in three provinces in papua new guinea: a cross-sectional survey. | background: papua new guinea (png) is estimated to have among the highest prevalences of hiv and sexually transmissible infections (stis) of any asia-pacific country, and one of the highest burdens of maternal syphilis globally. the prevalence of curable stis, such as chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv), among pregnant women in png is relatively unknown. methods: a cross-sectional bio-behavioural survey to investigate the epidemiology of ct, ng, ... | 2016 | 27248708 |
| chronic cervicitis: presenting features and response to therapy. | chronic nongonococcal nonchlamydial cervicitis is a condition of unknown etiology. data about treatment options are limited. our goal was to review a single center's experience in managing women with chronic ngncc. | 2016 | 27243142 |
| 2016 european guideline on the management of non-gonococcal urethritis. | we present the updated international union against sexually transmitted infections (iusti) guideline for the management of non-gonococcal urethritis in men. this guideline recommends confirmation of urethritis in symptomatic men before starting treatment. it does not recommend testing asymptomatic men for the presence of urethritis. all men with urethritis should be tested for chlamydia trachomatis and neisseria gonorrhoeae and ideally mycoplasma genitalium using a nucleic acid amplification tes ... | 2016 | 27147267 |
| detection of hpv and co-infecting pathogens in healthy italian women by multiplex real-time pcr. | several pathogens can be transmitted sexually and are an important cause of morbidity among sexually active women. the aim of the study was to detect the presence of human papillomavirus (hpv), chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), mycoplasma hominis (mh), mycoplasma genitalium (mg), ureaplasma urealyticum (uu), and ureaplasma parvum (up) in a group of 309 healthy women enrolled at the san camillo - forlanini hospital of rome by using two multiplex r ... | 2016 | 27031891 |
| association of human papillomavirus, neisseria gonorrhoeae and chlamydia trachomatis co-infections on the risk of high-grade squamous intraepithelial cervical lesion. | the link between high-risk human papillomavirus (hr-hpv) and other sexually transmitted diseases (stds) in the risk of developing cervical cancer still unclear. thus, in this report we investigated the rates of co-infections between hpv and other important non-hpv stds in different cervical findings using a multiplex polymerase chain reaction (m-pcr) to simultaneously detect chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, trichomonas vaginalis, hsv-1 and -2, and treponema pa ... | 2016 | 27429850 |
| association of human papillomavirus and chlamydia trachomatis with intraepithelial alterations in cervix samples. | the influence of different infectious agents and their association with human papillomavirus (hpv) in cervical carcinogenesis have not been completely elucidated. this study describes the association between cytological changes in cervical epithelium and the detection of the most relevant aetiological agents of sexually transmitted diseases. samples collected from 169 patients were evaluated by conventional cytology followed by molecular analysis to detect hpv dna, chlamydia trachomatis, herpes ... | 2016 | 26841046 |
| screening for abnormal vaginal microflora by self-assessed vaginal ph does not enable detection of sexually transmitted infections in ugandan women. | is self-assessed vaginal ph measurement to detect abnormal vaginal bacterial microflora (avf) an adequate prescreening method for detection of genital sexually transmitted infections (stis)? | 2016 | 27112831 |
| prevalence of trichomonas vaginalis and candida albicans among brazilian women of reproductive age. | there are no studies assessing the simultaneous occurrence of candida albicans (c. albicans) and trichomonas vaginalis (t. vaginalis) in the primary health care in brazil. despite different conditions to establishment of each one, the co-detection of both has been reported by some authors in previous studies from other regions. | 2016 | 28050410 |
| loop-mediated isothermal amplification (lamp) assay for the rapid detection of the sexually-transmitted parasite, trichomonas vaginalis. | a loop-mediated isothermal amplification (lamp) assay was developed to detect the sexually-transmitted parasite, trichomonas vaginalis in vaginal swabs. the presence of t. vaginalis was detected from 121 female sex workers attending a social hygiene clinic in balibago, angeles city, pampanga, philippines using culture, polymerase chain reaction (pcr), and the developed lamp assay. the high analytical sensitivity of lamp detected a higher prevalence of t. vaginalis (42.06%) compared to culture (8 ... | 2016 | 27262954 |
| a prospective observational study of vulvovagintis in pregnant women in argentina, with special reference to candidiasis. | to evaluate the frequency of yeast, bacteria or protozoa in pregnant women and to correlate the possible associations of these microorganisms and their relationships with vulvovaginitis (vv) and cervicitis. vaginal specimens were collected and prepared for smears in microscope slides for the evaluation of yeast, trichomonas vaginalis and bacteria. samples were cultured in specific culture medium. cervical specimens were used to investigate the presence of neisseria gonorrhoeae, chlamydia trachom ... | 2016 | 26931504 |
| affirm vpiii microbial identification test can be used to detect gardnerella vaginalis, candida albicans and trichomonas vaginalis microbial infections in korean women. | the aim of this study was to compare affirm vpiii microbial identification test results for korean women to those obtained for gardnerella vaginalis through nugent score, candida albicans based on vaginal culture and trichomonas vaginalis based on wet smear diagnostic standards. | 2016 | 26787446 |
| ammonium salts of carbamodithioic acid as potent vaginal trichomonacides and fungicides. | chemical attenuation of the reactive oxygen species (ros)-sensitive anaerobes trichomonas vaginalis, which is the most prevalent non-viral sexually transmitted infection, and two often coexisting vaginal infections, namely candida albicans and staphylococcus aureus, which are opportunistic reproductive tract infections, was attempted with novel ammonium salts of carbamodithioic acid through inhibition of free thiols. in vitro and in vivo efficacies of the designed compounds were evaluated as top ... | 2016 | 26706422 |
| gentamicin versus ceftriaxone for the treatment of gonorrhoea (g-tog trial): study protocol for a randomised trial. | gonorrhoea is a common sexually transmitted infection which causes genital pain and discomfort; in women it can also lead to pelvic inflammatory disease and infertility, and in men to epididymo-orchitis. current treatment is with ceftriaxone, but there is increasing evidence of antimicrobial resistance which is reducing its effectiveness against gonorrhoea. a small, but increasing, number of patients have already been found to have highly resistant strains of gonorrhoea which has been associated ... | 2016 | 27881151 |
| menstrual cups and sanitary pads to reduce school attrition, and sexually transmitted and reproductive tract infections: a cluster randomised controlled feasibility study in rural western kenya. | conduct a feasibility study on the effect of menstrual hygiene on schoolgirls' school and health (reproductive/sexual) outcomes. | 2016 | 27881530 |
| sti tests and proportion of positive tests in female sex workers attending local public health departments in germany in 2010/11. | in germany, local public health departments (lphd) are required to offer low-threshold access to confidential counselling and testing for sexually transmitted infections (sti) for sex workers. we collected data from lphd in germany to estimate the number of performed sti tests and the proportion of positive sti tests among attending female sex workers (fsw) in order to formulate recommendations for improving sti testing and care for fsw in germany. | 2016 | 27871264 |
| the performance of the vaginal discharge syndromic management in treating vaginal and cervical infection: a systematic review and meta-analysis. | this review aimed to synthesize and analyze the diagnostic accuracy and the likelihood of providing correct treatment of the syndromic approach vaginal discharge flowchart in managing cervical infections caused by neisseria gonorrhoeae (ng) and chlamydia trachomatis (ct), and vaginal infections caused by trichomonas vaginalis (tv) and bacterial vaginosis (bv) and candida albicans. this review will inform updating the who 2003 guidelines on vaginal discharge syndromic case management. | 2016 | 27706174 |
| detection of trichomonas vaginalis in prostate tissue and serostatus in patients with asymptomatic benign prostatic hyperplasia. | despite a worldwide common and progressive nature of benign prostate hyperplasia (bph) in older men, no association has been observed between a causative pathogen and other etiology so far. | 2016 | 27660027 |
| mycoplasma genitalium prevalence, coinfection, and macrolide antibiotic resistance frequency in a multicenter clinical study cohort in the united states. | the prevalence rates of mycoplasma genitalium infections and coinfections with other sexually transmitted organisms and the frequency of a macrolide antibiotic resistance phenotype were determined in urogenital specimens collected from female and male subjects enrolled in a multicenter clinical study in the united states. specimens from 946 subjects seeking care from seven geographically diverse clinical sites were tested for m. genitalium and for chlamydia trachomatis, neisseria gonorrhoeae, an ... | 2016 | 27307460 |