Publications

genetic analysis of human hematological malignancies rewarded.		2007	17404608
evaluation of the risk for tay-sachs disease in individuals of french canadian ancestry living in new england.	the assessment of risk for tay-sachs disease (tsd) in individuals of french canadian background living in new england is an important health issue. in preliminary studies of the enzyme-defined carrier frequency for tsd among franco-americans in new england, we found frequencies (1:53) higher than predicted from the incidence of infantile tsd in this region. we have now further evaluated the risk for tsd in the franco-american population of new england.	2007	17259242
tag polymorphisms at the a20 (tnfaip3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.	a20 or tumor necrosis factor (tnf)-induced protein 3 (tnfaip3) is a negative regulator of nuclear factor-kappab (nf-kappab). we have investigated whether polymorphisms in this gene are associated with increased atherosclerosis in diabetic patients. five tag single nucleotide polymorphisms (snps) were typed in 479 type 2 diabetic patients from boston, including 239 coronary artery disease (cad)-positive case subjects and 240 cad-negative control subjects. two tag snps (rs5029930 and rs610604) wer ...	2007	17259397
open-access database of candidate associations from a genome-wide snp scan of the framingham heart study.		2007	17262019
human eastern equine encephalitis in massachusetts: predictive indicators from mosquitoes collected at 10 long-term trap sites, 1979-2004.	human eastern equine encephalitis (eee) is a life-threatening mosquito-borne disease. to determine whether mosquito abundance and eee virus infection rates are associated with human eee disease, we evaluated retrospectively a total of 592,637 mosquitoes and onset dates for 20 confirmed human cases over 26 years in massachusetts. annual culiseta melanura populations at 10 defined sites decreased over the study period (p = 0.002). weekly infection rates and number of infected culiseta melanura cap ...	2007	17297037
breast milk iodine and perchlorate concentrations in lactating boston-area women.	breastfed infants rely on adequate maternal dietary iodine intake.	2007	17311853
adult and pediatric emergency department sexually transmitted disease and hiv screening: programmatic overview and outcomes.	to measure the prevalence of gonorrhea, chlamydia, and human immunodeficiency virus (hiv) infection among emergency department (ed) patients who accept screening, and to assess treatment outcomes and risks for infection.	2007	17331918
america's changing attitudes toward homosexuality, civil unions, and same-gender marriage: 1977-2004.	on may 17, 2004, massachusetts became the first state to legalize same-gender marriage. from california to missouri, nearly all states now face legislative challenges to the once firmly entrenched notion that marriage can only exist between a man and a woman. public opinion polls conducted from 1977 to 2004 found that americans' attitudes toward gay men and lesbians and marriages or civil unions for same-gender couples have evolved. opposition persists, however. the most recent data indicate sup ...	2007	17388085
human exposure to pbdes: associations of pbde body burdens with food consumption and house dust concentrations.	this study was designed to determine the body burden of polybrominated diphenyl ethers (pbdes) among first-time mothers in the greater boston, massachusetts area and to explore key routes of exposure. we collected breast milk samples from 46 first-time mothers, 2-8 weeks after birth. we also sampled house dust from the homes of a subset of participants by vacuuming commonly used areas. data on personal characteristics, diet, home furniture, and electrical devices were gathered from each particip ...	2007	17396645
klebsiella pneumoniae necrotizing fasciitis and septic arthritis: an appearance in the western hemisphere.	necrotizing fasciitis caused by klebsiella pneumoniae is rare, with 11 documented cases in the literature, all occurring in asia and the middle east. these reports have become more frequent in recent years in association with the emergence of the highly virulent k1 capsular serotype of klebsiella. we report a case of klebsiella necrotizing fasciitis and con-current septic arthritis in the western hemisphere.	2007	17437368
auto identification technology and its impact on patient safety in the operating room of the future.	automatic identification technologies, such as bar coding and radio frequency identification, are ubiquitous in everyday life but virtually nonexistent in the operating room. user expectations, based on everyday experience with automatic identification technologies, have generated much anticipation that these systems will improve readiness, workflow, and safety in the operating room, with minimal training requirements. we report, in narrative form, a multi-year experience with various automatic ...	2007	17442879
lyme disease--united states, 2003-2005.	lyme disease is caused by the spirochete borrelia burgdorferi and is transmitted to humans by the bite of infected blacklegged ticks (ixodes spp.). early manifestations of infection include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. left untreated, late manifestations involving the joints, heart, and nervous system can occur. a healthy people 2010 objective (14-8) is to reduce the annual incidence of lyme disease to 9.7 new cases per 100,000 population in 1 ...	2007	17568368
synthetic musk fragrances in human milk from the united states.	synthetic musk compounds are used as additives in many consumer products, including perfumes, deodorants, and detergents. earlier studies have reported the occurrence of synthetic musks in environmental and wildlife samples collected in the united states. in this study, human breast milk samples collected from massachusetts, were analyzed for the determination of concentrations of synthetic musks such as musk xylene (1-tert-butyl-3,5-dimethyl-2,4,6-trinitrobenzene), musk ketone (4-tert-butyl-2,6 ...	2007	17612154
xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery.	in the national emphysema treatment trial (nett), marked variability in response to lung volume reduction surgery (lvrs) was observed. we sought to identify genetic differences which may explain some of this variability.	2007	17686149
modifying effects of the hfe polymorphisms on the association between lead burden and cognitive decline.	as iron and lead promote oxidative damage, and hemochromatosis (hfe) gene polymorphisms increase body iron burden, hfe variant alleles may modify the lead burden and cognitive decline relationship.	2007	17687449
the association of abuse and symptoms suggestive of chronic prostatitis/chronic pelvic pain syndrome: results from the boston area community health survey.	to determine the effect of reported sexual, physical, or emotional abuse on the symptoms suggestive of chronic prostatitis/chronic pelvic pain syndrome (cp/cpps) and to determine the effect of race/ethnicity on these patterns.	2007	17763912
nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring.	there is a paucity of information about risk factors for the human eye anomalies anophthalmia and microphthalmia. in this population-based case-control study we investigated whether periconceptional intakes of supplemental folic acid, dietary folate, vitamin a, and several other nutrients were associated with these eye defects.	2007	17847120
a 100k genome-wide association scan for diabetes and related traits in the framingham heart study: replication and integration with other genome-wide datasets.	to use genome-wide fixed marker arrays and improved analytical tools to detect genetic associations with type 2 diabetes in a carefully phenotyped human sample.	2007	17848626
the framingham heart study, on its way to becoming the gold standard for cardiovascular genetic epidemiology?	the framingham heart study, founded in 1948 to examine the epidemiology of cardiovascular disease in a small town outside of boston, has become the worldwide standard for cardiovascular epidemiology. it is among the longest running, most comprehensively characterized multi-generational studies in the world. such seminal findings as the effects of smoking and high cholesterol on heart disease came from the framingham heart study. at the time of publication these were novel cardiovascular disease ...	2007	17916250
blinded comparison of computer-aided detection with human second reading in screening mammography.	the purpose of this study was to compare a human second reader with computer-aided detection (cad) for the reduction of false-negative cases by a primary radiologist. we retrospectively reviewed our clinical practice.	2007	17954651
blinded comparison of computer-aided detection with human second reading in screening mammography: the importance of the question and the critical numbers game.		2007	17954652
impact of september 11 on refugees and those seeking asylum.	september 11, 2001 profoundly affected the american public. we share the views of a cohort of refugees and those seeking asylum from the boston center for refugee health and human rights. of the 63 individuals from 18 countries interviewed, many had concerns about their personal safety following september 11, as well as fears related to deportation, arrest, detention, imprisonment, discrimination, physical violence and the destruction of property, and war. asylum seekers were more likely than re ...	2007	18089639
integrating professional behavior development across a professional allied health curriculum.	professional behaviors are an integral part of clinical practice in all allied health and medical fields. a systematic process for instruction, the education, and development of professional behaviors, cannot be taught in the same way that memorization of human anatomy or medical terminology is taught. one cannot expect professional behaviors to just appear in an individual upon graduation and entry into a health care field. professional behavior development is an essential component of physical ...	2007	19759999
legislating fear and the public health in gilded age massachusetts.	between 1876 and 1881 massachusetts experienced an outbreak of human rabies (hydrophobia). the entire state--the governor, the legislature, the state board of health, newspapers, and the citizenry and elected officials of every town and city--reacted to the disease. central to the response was the commonwealth's legislature--called the general court. through public hearings, their own debates, and the passage of legislation, it resolved widespread fear and anger, mediated conflicting concepts of ...	2007	16980330
reproductive deficits in male freshwater turtle chrysemys picta from cape cod, massachusetts.	contaminated groundwater plumes have formed on the massachusetts military reservation (mmr), a superfund site on cape cod, massachusetts, as a result of chemical waste disposal. the plumes are of concern to the local people who rely on groundwater as a drinking water source. we used the freshwater turtle as a sentinel species to monitor the reproductive effects of exposure and, by inference, the potential for impact on human health. our observations of male chrysemys picta field-trapped from moo ...	2007	17123946
polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome.	the variant alleles in the mannose binding lectin-2 (mbl-2) gene have been associated with mbl deficiency and increased susceptibility to sepsis. we postulate that the variant mbl-2 genotypes are associated with increased susceptibility to and mortality in acute respiratory distress syndrome (ards).	2007	17133182
cross-cultural considerations in the conduct of community-based participatory research.	this article explores cross-cultural challenges that arise when university and community members collaborate in community-based participatory research. as part of a project for primary prevention of human immunodeficiency virus (hiv) infection, researchers trained community leaders to jointly develop a research question and conduct a pilot qualitative study in a puerto rican community in massachusetts. different priorities of the community and university members about hiv as a research topic und ...	2007	17149031
organochlorine exposures during pregnancy and infant size at birth.	organochlorines, including polychlorinated biphenyls (pcbs) and pesticides, are environmentally persistent contaminants that concentrate in the food chain as well in human adipose tissue and readily cross the placenta.	2007	17179760
incessant ovulation, mucin 1 immunity, and risk for ovarian cancer.	risk for ovarian cancer correlates directly with "ovulatory years or cycles" estimated from time not pregnant, breast-feeding, or using oral contraceptives. recently, we reported that several factors known to reduce ovarian cancer risk may operate by inducing antibodies against mucin 1 (muc1), a glycoprotein overexpressed in ovarian cancer. conversely, other events might increase risk by interfering with the development of protective immunity. in this study, we examined whether the total number ...	2007	17220329
global dna methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma.	head and neck squamous cell carcinoma (hnscc) is commonly associated with tobacco and alcohol exposures, although dietary factors, particularly folate, and human papillomavirus, are also risk factors. epigenetic alterations are increasingly implicated in the initiation and progression of cancer. genome-wide (global) hypomethylation seems to occur in early neoplasia and is a feature of genomic dna derived from solid tumor tissues, including hnscc. this study aimed to determine whether global meth ...	2007	17220338
reengineering real time outbreak detection systems for influenza epidemic monitoring.	in the wake of fears over pandemic influenza, triggered by concern about avian influenza, a top national priority is to adapt surveillance systems, such as biosense, for influenza monitoring. while real time surveillance system architects have been largely focused on the problem of discrete outbreak detection, the data in these systems have been shown to have unique advantages for the timely detection of influenza. in this study, we evaluate the utility influenza detection by real-time surveilla ...	2006	17238486
phylogenetic and biologic evidence that babesia divergens is not endemic in the united states.	the causative agent of human babesiosis in a kentucky case, which was first identified as babesia divergens, is identical to a parasite of eastern cottontail rabbits on nantucket island, massachusetts based on piroplasm size, morphology, and ribosomal rna sequence analysis. studies showing differential infectivity for cattle, host erythrocyte specificity in vitro, parasite size and morphology in vitro, and ribosomal rna sequences clearly demonstrate that the parasite from the rabbit (conspecific ...	2006	17135561
hfe genotype, particulate air pollution, and heart rate variability: a gene-environment interaction.	particulate air pollution has been associated with cardiovascular mortality and morbidity. transition metals such as iron bound to the particles may be responsible for those associations. the protein product of the hemochromatosis (hfe) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. two hfe polymorphisms (c282y and h63d) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system.	2006	17145987
optimizing resource allocation in united states aids drug assistance programs.	us acquired immunodeficiency syndrome (aids) drug assistance programs (adaps) provide medications to low-income patients with human immunodeficiency virus (hiv) infection/aids. nationally, adaps are in a fiscal crisis. many states have instituted waiting lists, often serving clients on a first-come, first-served basis. we hypothesized that cd4 cell count-based adap eligibility would improve adap outcomes, allowing them to serve more-diverse patient populations and to prioritize persons who are a ...	2006	17051505
social hazards on the job: workplace abuse, sexual harassment, and racial discrimination--a study of black, latino, and white low-income women and men workers in the united states.	this study documents the prevalence of workplace abuse, sexual harassment at work, and lifetime experiences of racial discrimination among the united for health cohort of 1,202 predominantly black, latino, and white women and men low-income union workers in the greater boston area. overall, 85 percent of the cohort reported exposure to at least one of these three social hazards; exposure to all three reached 20 to 30 percent among black women and women and men in racial/ethnic groups other than ...	2006	16524165
low risk of relapse after achieving undetectable hcg levels in women with partial molar pregnancy.	we evaluated the risk of gestational trophoblastic neoplasia (gtn) for women with partial molar pregnancy whose human chorionic gonadotropin (hcg) levels fall spontaneously to undetectable levels using a sensitive hcg assay.	2006	16880311
influenza vaccine for school-aged children.		2006	16882851
a tale of three cities--where rhios meet the nhin.	regional health information exchanges in california, indiana, and massachusetts have been collaborating on a prototype for a nationwide health information network, first under the auspices of the markle foundation's connecting for health program and now under contract to the department of health and human services' office of the national coordinator for health information technology. since mid-2004, this collaboration has evolved from a collection of regional efforts to a standards-driven cooper ...	2006	16903663
the rise and demise of a collection of human fetuses at mount holyoke college.	when i found myself at the center of a controversy over the disposition of an old collection of human fetal specimens at mount holyoke college, i was motivated to explore the historical transformation that turned embryo collecting for research and pedagogical purposes from a noble to a disparaged practice, and dead fetuses from prized anatomical specimens to ugly, anomalous entities. using linda layne's analysis of the literal and symbolic erasure of dead fetuses from american cultural discourse ...	2006	16960312
boston hospital drill tests pandemic flu readiness.		2006	16390922
hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the framingham offspring study.	endothelial dysfunction may precede development of type 2 diabetes. we tested the hypothesis that elevated levels of hemostatic markers of endothelial dysfunction, plasminogen activator inhibitor-1 (pai-1) antigen, and von willebrand factor (vwf) antigen predicted incident diabetes independent of other diabetes risk factors. we followed 2,924 framingham offspring subjects (54% women, mean age 54 years) without diabetes at baseline (defined by treatment, fasting plasma glucose > or =7 or 2-h post ...	2006	16443791
detection of babesia and anaplasma species in rabbits from texas and georgia, usa.	rabbits have been shown to harbor a suite of zoonotic organisms, including a babesia species, borrelia burgdorferi, and anaplasma phagocytophilum. in this study, we conducted a molecular survey for various tick-borne pathogens in three species of rabbits from texas and georgia. of 18 black-tailed jackrabbits (lepus californicus) tested from texas, six (28%) were polymerase chain reaction (pcr) positive for babesia, and nucleotide sequencing revealed two distinct species or strains. two jackrabbi ...	2006	16584322
utilization of the medical librarian in a state medicaid program to provide information services geared to health policy and health disparities.	objective: the role of two solo medical librarians in supporting medicaid programs by functioning as information specialists at regional and state levels is examined. setting: a solo librarian for the massachusetts medicaid (masshealth) program and a solo librarian for the new england states consortium systems organization (nescso) functioned as information specialists in context to support medicaid policy development and clinical, administrative, and program staff for state medicaid programs. b ...	2006	16636710
characteristics and utilization of primary care services in a torture rehabilitation center.	we conducted a retrospective chart review to look into the utilization of healthcare services of refugees. between december 1998 and june 2001, 146 refugees received care at the boston center for refugee health and human rights. the mean age was 39+/- 1 years; 57% were males, and 84% were survivors of torture. a significant number of patients were diagnosed with major depression (70%), post-traumatic stress disorder (58%), past hepatitis a infection (77%), and tuberculosis classes 2 and 3 (42%). ...	2006	16649131
estrogenic activity of polychlorinated biphenyls present in human tissue and the environment.	this study evaluated the estrogenicity of polychlorinated biphenyls (pcbs) present in environmental media and human tissue and assessed exposure pathways for pcb-derived estrogenic potency in air, soil, and dust from new bedford, ma, an area with a pcb-contaminated superfund site. thirty-four pcb congeners were assayed for estrogenic potency using e-screen, an assay based on the estrogen-dependent proliferation of mcf-7 cells in vitro. childhood exposure to estradiol-equivalents via pcbs in envi ...	2006	16683629
forearm electromyographic changes with the use of a haptic force-feedback computer mouse.	to examine changes in biomechanical and motor control associated with a force-feedback computer mouse.	2006	16696263
becoming the harvard man: person-environment fit, personality development, and academic success.	the continuity and change of the needs and evaluations of the college environment and person-environment fit (pe fit) with the college environment were studied in a 4-year longitudinal study of students (n = 191). perceptions of the environment changed more dramatically than corresponding self-perceived needs. pe fit demonstrated moderate levels of consistency over the 4-year span, but no significant increases in mean levels were found over time. antecedents to pe fit in the college environment ...	2006	16738020
blood cultures do not change management in hospitalized patients with community-acquired pneumonia.	to determine if blood cultures identify organisms that are not appropriately treated with initial empiric antibiotics in hospitalized patients with community-acquired pneumonia, and to calculate the costs of blood cultures and cost savings realized by changing to narrower-spectrum antibiotics based on the results.	2006	16766742
corticosterone responses change seasonally in free-living house sparrows (passer domesticus).	avian corticosterone (cort) concentrations vary seasonally for many species, but most studies examined species from extreme environments or from only a few times of the year. it is unclear how general a phenomenon this is. we examined both baseline and stress-induced cort from house sparrows (passer domesticus) in two habitats-massachusetts, similar to their ancestral habitat; and new mexico, a semi-arid desert where the house sparrow only thrives as an obligate human commensal. we captured both ...	2006	16774754
global health database.	the global health database is available from ovid technologies, inc., and also from cabi publishing, ebsco, and datastar/ dialog. this database is really the combination of two others--the public health and tropical medicine database, formerly produced by the bureau of hygiene and tropical diseases, as well as human health and diseases information that is extracted from the cab abstracts database. this column will provide readers with an overview of the global health database, as well as present ...	2006	16782667
comparison of reactivity and epitope recognition between sera from american and italian patients with oral pemphigoid.	mucous membrane pemphigoid (mmp) (also known as cicatricial pemphigoid) is a rare autoimmune mucocutaneous blistering disease that affects mucous membranes derived from stratified squamous epithelium and the skin. a subset of mmp affects only the oral cavity and is referred to as the oral pemphigoid (op). mmp and op are characterized by subepithelial vesicles on histology and in vivo deposition of immunoglobulins and complement at the basement membrane zone (bmz) on immunopathology. previous stu ...	2006	16792670
eastern equine encephalitis--new hampshire and massachusetts, august-september 2005.	during august-september 2005, the new hampshire department of health and human services reported seven cases of human eastern equine encephalitis virus (eeev) disease, the first laboratory-confirmed, locally acquired cases of human eeev disease reported from new hampshire in 41 years of national surveillance. also during august--september 2005, the massachusetts department of public health reported four cases of human eeev disease, five times the annual average of 0.8 cases reported from massach ...	2006	16810146
influenza and other respiratory virus-related emergency department visits among young children.	influenza and other winter respiratory viruses cause substantial morbidity among children. previous estimates of the burden of illness of these viruses have neglected to include the emergency department, where a large number of patients seek acute care for respiratory illnesses. this study provides city- and statewide population estimates of the burden of illness attributable to respiratory viruses for children receiving emergency department-based care for respiratory infections during the winte ...	2006	16818524
gb virus c (gbv-c) infection in hepatitis c virus (hcv)/hiv-coinfected patients receiving hcv treatment: importance of the gbv-c genotype.	persistent gb virus c (gbv-c) coinfection leads to slower human immunodeficiency virus (hiv) progression. despite the existence of multiple gbv-c genotypes, their relevance to the progression of hiv disease is unknown. we therefore investigated (1) the prevalence and genotype of gbv-c in hepatitis c virus (hcv)/hiv-coinfected patients and (2) the impact of hcv treatment on gbv-c rna clearance.	2006	16845623
effects of local variation, specialty, and beliefs on antiviral prescribing for influenza.	in 2004, we conducted a survey of physician knowledge, attitudes, and practices regarding influenza diagnosis and treatment at baystate medical center in massachusetts and scott & white hospital and clinic in texas. of the 579 physicians we contacted, 336 completed the survey. sixty-one percent of the respondents prescribed antivirals, and 62% used rapid testing. prescribing practices were associated with location, practice size, use of rapid testing, and belief in the efficacy of antivirals.	2006	16323098
menstrual cycle characteristics: associations with fertility and spontaneous abortion.	epidemiologists often use menstrual cycle patterns as indicators of endocrine function in environmental and occupational studies, yet few studies have considered whether menstrual cycle characteristics are associated with fertility or pregnancy outcome.	2006	16357595
blood lead levels of wild steller's eiders (polysticta stelleri) and black scoters (melanitta nigra) in alaska using a portable blood lead analyzer.	sea duck populations are declining in alaska. the reasons for the decline are not known; environmental lead exposure is one suspected cause. thirty wild steller's eider ducks (polysticta stelleri) and 40 wild black scoter ducks (melanitta nigra) were tested for blood lead levels using a portable blood lead analyzer (leadcare; esa, inc., chelmsford, massachusetts 01824, usa). sixty-seven and one-tenth percent of the sea ducks had undetectable blood lead levels, 30.0% had values indicating normal ...	2006	17319136
the top 10 health stories of 2006.		2006	17297726
spondylitic changes in long-finned pilot whales (globicephala melas) stranded on cape cod, massachusetts, usa, between 1982 and 2000.	the primary bone pathology diagnoses recognized in cetacea are osteomyelitis and spondylosis deformans. in this study, we determined the prevalence, type, and severity of vertebral pathology in 52 pilot whales, a mass stranding species that stranded on cape cod, massachusetts, between 1982 and 2000. eleven whales (21%) had hyperostosis and ossification of tendon insertion points on and between vertebrae, chevron bones, and costovertebral joints, with multiple fused blocks of vertebrae. these les ...	2005	16456160
genome-wide linkage analysis to age at natural menopause in a community-based sample: the framingham heart study.	to identify chromosomal regions linked to age at natural menopause.	2005	16359963
rabies surveillance in the united states during 2004.	during 2004, 49 states and puerto rico reported 6,836 cases of rabies in nonhuman animals and 8 cases in human beings to the cdc, representing a 4.6% decrease from the 7,170 cases in nonhuman animals and 3 cases in human beings reported in 2003. approximately 92% of the cases were in wildlife, and 8% were in domestic animals (compared with 91% and 9%, respectively, in 2003). relative contributions by the major animal groups were as follows: 2,564 raccoons (37.5%), 1,856 skunks (27.1%), 1,361 bat ...	2005	16379626
genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the framingham heart study.	microalbuminuria is a powerful risk factor for cardiovascular disease. it is not known whether genetic factors play a role in the expression of microalbuminuria in population-based samples.	2005	15610229
evidence for a gene influencing haematocrit on chromosome 6q23-24: genomewide scan in the framingham heart study.		2005	15635079
population-based surveillance for childhood invasive pneumococcal disease in the era of conjugate vaccine.	heptavalent pneumococcal conjugate vaccine was licensed in the united states in february 2000 and, following national guidelines, universally distributed in massachusetts starting in july 2000 to children younger than 2 years of age and selected children 2-5 years of age. we performed statewide surveillance for all cases of invasive pneumococcal disease (ipd) in children younger than 18 years of age to determine risk features and contribution of vaccine failure to ongoing pneumococcal invasive d ...	2005	15665705
urologic complications of sexual trauma among male survivors of torture.	to describe the urologic and sexual complications of male survivors of sexual torture, including prevalence, sequelae, diagnosis, and treatment.	2005	15667857
professor joseph warren horton (1889-1967): biological engineer.	joseph warren horton graduated with a degree in electrical engineering from the massachusetts institute of technology (mit) in 1914. he became involved in the early development of electrical measurement devices, televised image transmission, and the detection of underwater sound transmission. in the mid-1930s he was appointed the first leader of the newly created department of biological engineering at mit and in this position he made major contributions to the application of physics to human ph ...	2005	15682231
therapies for viral hepatitis workshop. 2-3 november 2004, boston, ma, usa.		2005	15696414
benefits for employees with children with adhd: findings from the collaborative employee benefit study.	parents of most children with attention-deficit hyperactivity disorder (adhd) are employed. employers have interest in decreasing employee absenteeism and improving workplace productivity, partly through employee benefits. the authors interviewed employers to (1) determine how they view the needs of employees with children with adhd and (2) identify benefits that might help employees with children with adhd. the authors carried out a systematic interview study of mainly family-friendly, large em ...	2005	15718875
[new study on the history of anesthesiology--(11) three japanese doctors who observed william tg morton's ether anesthesia at the gross clinic in 1860].	in january of 1860 the tokugawa shogunate dispatched a group of japanese mission headed by masaoki niimi, the first ambassador, to washington d.c. to exchange ratification of japan-united states treaty of commerce and amity. on may 22nd the ratification was approved. they left washington d.c. to move to baltimore and philadelphia to visit various sites and institutions. the niagara sailed from new york with the japanese mission on board on june 30th. in philadelphia three japanese medical doctor ...	2005	15747522
challenges in the treatment of patients coinfected with hiv and hepatitis c virus: need for team care.	we estimate that only one-third of patients coinfected with hepatitis c virus (hcv) and human immunodeficiency virus (hiv) are eligible for therapy for hcv with interferon (ifn) and ribavirin, and, of those who are eligible, two-thirds decline treatment. to date we have initiated treatment with ifn and ribavirin for 8% of coinfected patients evaluated, and <1% of patients have had a sustained virological response. during this process, we have identified many problems that significantly limit our ...	2005	15768347
jacobson v massachusetts: it's not your great-great-grandfather's public health law.	jacobson v massachusetts, a 1905 us supreme court decision, raised questions about the power of state government to protect the public's health and the constitution's protection of personal liberty. we examined conceptions about state power and personal liberty in jacobson and later cases that expanded, superseded, or even ignored those ideas. public health and constitutional law have evolved to better protect both health and human rights. states' sovereign power to make laws of all kinds has no ...	2005	15798113
genome-wide linkage analyses and candidate gene fine mapping for hdl3 cholesterol: the framingham study.	high density lipoprotein cholesterol (hdl-c) is inversely associated with coronary heart disease and has a genetic component; however, linkage to hdl-c is not conclusive. subfractions of hdl, such as hdl(3)-c, may be better phenotypes for linkage studies. using hdl(3)-c levels measured on 907 framingham heart study subjects from 330 families around 1987, we conducted a genome-wide variance components linkage analysis with 401 microsatellite markers spaced approximately 10 centimorgan (cm) apart. ...	2005	15805549
integrating the criminal justice system into mental health service delivery: the worcester diversion experience.	the substantial number of persons with mental illness encountered in many sectors of the criminal justice system has spurred actors from various agencies within that system to take actions aimed at reducing the growth of this population. these actions have included the development of specialty police units, jail diversion programs, and other mechanisms for channeling persons with mental illness out of the criminal justice system and into mental health treatment. the courts, too, have become invo ...	2005	15818600
seeds of change: using peacemaking circles to build a village for every child.	roca, inc., a grassroots human development and community organization, has adopted the peacemaking circle as a tool in its relationship building with youth, communities, and formal systems. circles are a method of communication derived from aboriginal and native traditions. in massachusetts, the department of social services and the department of youth services are exploring the application of the circle in programming with youth and families. by providing a consistent structure for open, democr ...	2005	15828408
a model to provide comprehensive testing for hiv, viral hepatitis, and sexually transmitted infections at a short-term drug treatment center.	substance users are at high risk for blood-borne infections as well as those that are transmitted sexually. substance abuse treatment centers present an opportunity to offer comprehensive counseling and testing (cct) for hiv, viral hepatitis, and sexually transmitted infections (stis) to this high-risk population. we examined the feasibility and acceptability of one model of cct among substance users. cct was offered to 145 consecutive inpatients; study participants completed a risk factor quest ...	2005	15916492
decision making for hiv prevention planning: organizational considerations and influencing factors.	the purpose of this cdc-funded project was to better understand how behavioral data were used in hiv prevention community planning, and use this knowledge to develop and evaluate tools for increasing the use of data in hiv prevention planning. hiv prevention community planning represents one of many efforts, in a variety of health and human service areas, to formulate plans and policies that are evidence-based and reflective of community input. the attention to evidence-based planning and the in ...	2005	15933825
carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities.	animal studies suggest a role for dietary carbohydrate in cataractogenesis. however, few published human studies have evaluated associations between carbohydrate nutrition and lens opacification.	2005	15941895
occurrence and correlations between coliphages and anthropogenic viruses in the massachusetts bay using enrichment and icc-npcr.	we evaluated a two-step enrichment procedure to detect coliphages and an integrated cell culture-nested polymerase chain reaction (icc-npcr) to detect human astrovirus, enteroviruses, rotavirus and adenovirus type 40 and 41 in marine water samples collected by the massachusetts water resource authority (mwra). mwra has been monitoring its receiving waters for coliphages, anthropogenic viruses and indicator bacteria in order to evaluate the impact of boston's deer island sewage treatment plant di ...	2005	15952453
the predictable swarm: staying on top of radiology's cyclical staffing "bug".	partners healthcare system in boston, ma, took some progressive and bold steps to address the recent staffing shortages in radiology. by addressing the shortage at the system level versus the individual hospital level, partners was able to successfully recruit and support more than 80 new radiologic technologists from initial interest through graduation in 2 years. the recruitment effort helped reduce the utilization of temporary/agency personnel that cost the system more than dollar 6 million i ...	2005	15988868
identifying pediatric age groups for influenza vaccination using a real-time regional surveillance system.	evidence is accumulating that universal vaccination of schoolchildren would reduce the transmission of influenza. the authors sought to identify target age groups within the pediatric population that develop influenza the earliest and are most strongly linked with mortality in the population. patient visits for respiratory illness were monitored, using real-time syndromic surveillance systems, in six massachusetts health-care settings, including ambulatory care sites and emergency departments at ...	2005	16107568
ccl2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the framingham heart study.	monocyte chemoattractant protein-1 (mcp-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory.	2005	16116069
common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community.	sequence variants at the endothelial nitric oxide synthase (nos3) locus have been associated with endothelial function measures, but replication has been limited.	2005	16129794
support for the use of thermoplastic bite impressions to aid in the identification of missing and unknown children.	this paper presents a response to the editorial opinion expressed in the position paper "promotion of the use of a thermoplastic material to aid in the identification of unidentified human remains," published on page 14 of this issue of the journal of the massachusetts dental society. no references were cited in that paper: because the mission of the american board of forensic odontology (abfo) is to "promote and enhance the science of forensic odontology" and realizing that the abfo guidelines ...	2005	16149396
the rage gly82ser polymorphism is not associated with cardiovascular disease in the framingham offspring study.	the receptor for advanced glycation end-products (rage) is expressed to enhance degrees in human atherosclerotic plaques and co-localizes with inflammatory and pro-oxidant mediators in the vulnerable regions of the plaque. previous studies highlighted a number of variants in the gene encoding the receptor, including a gly to ser substitution at amino acid 82 within the ligand-binding domain of rage. the ser82 allele enhanced ligand-binding affinity and increased ligand-stimulated generation of i ...	2005	16159602
genome scan of systemic biomarkers of vascular inflammation in the framingham heart study: evidence for susceptibility loci on 1q.	vascular inflammation plays a central role in atherosclerosis and inflammatory biomarkers predict risk of cardiovascular disease (cvd). thus, finding genes that influence systemic levels of inflammatory biomarkers may provide insights into genetic determinants of vascular inflammation and cvd. we conducted variance-component linkage analyses of blood levels of four biomarkers of vascular inflammation [c-reactive protein (crp), interleukin-6 (il-6), monocyte chemoattractant protein-1 (mcp-1), sol ...	2005	16159603
diagnostic dilemmas resulting from the immunoreactive trypsinogen/dna cystic fibrosis newborn screening algorithm.	to quantitate the proportion of infants identified through cystic fibrosis (cf) newborn screening (nbs) by an immunoreactive trypsinogen (irt)/dna screening algorithm who have an unclear diagnosis as defined by the findings of an elevated irt level and either 1) 2 cf gene (cftr) mutations detected and sweat chloride level <60 meq/l; or 2) 0 or 1 cftr mutations and a "borderline" sweat chloride level >or=30 and <60 meq/l.	2005	16202789
battered mothers speak out: participatory human rights documentation as a model for research and activism in the united states.	this article describes the work of the battered mothers' testimony project, a multiyear effort that documented human rights violations against battered women and their children in the massachusetts family court system. this article (a) presents the battered mothers' testimony project's participatory human rights methodology as an alternative model for research and activism on violence against women and children in the united states, (b) summarizes the authors' findings and human rights analysis ...	2005	16204730
the fatty acid-binding protein-2 a54t polymorphism is associated with renal disease in patients with type 2 diabetes.	the intestinal fatty-acid binding protein-2 (fabp2) gene codes a protein responsible for the absorption of long-chain fatty acids. to test whether fabp2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional a54t polymorphism was genotyped in 1,042 brazilians with type 2 diabetes. patients were classified as having normoalbuminuria (urinary albumin excretion [uae] <20 microg/min; n = 529), microalbuminuria (uae 20-199 microg/min; n = 217), or proteinuria (uae >199 m ...	2005	16249461
reliable exposure assessment strategies for physical ergonomics stressors in construction and other non-routinized work.	the objective of this research was to provide guidelines for the reliable assessment of ergonomics exposures in non-routinized work. using a discrete-interval observational sampling approach, two or three observers collected a total of 5852 observations on tasks performed by three construction trades (iron workers, carpenters and labourers) for periods of several weeks. for each observation, nine exposure variables associated with awkward body postures, tool use and load handling were recorded. ...	2005	16251156
genome-wide search for genes affecting serum uric acid levels: the framingham heart study.	serum uric acid levels are associated with hypertension, cardiovascular disease, and renal disease. uric acid has been shown to be heritable; however, genome-wide linkage analyses have not been reported. genome-wide multipoint variance components linkage analyses with 401 markers spaced at approximately 10 centimorgan (cm) were conducted on 1258 subjects of the framingham heart study, using the average of two serum uric acid measurements obtained in examinations 1 and 2 around 1971 and 1979. cov ...	2005	16253630
proper positioning of clients: a risk for caregivers.	the primary objective of this study was to learn more about the occupational risk of client repositioning by caregivers. this study also included information on frequency demands and factors contributing to the need to reposition clients and future risk-reduction solutions and interventions. a questionnaire was administered to caregivers at 12 hospitals. targeted groups were client care units with caregivers who are required to reposition clients in bed. the task of client repositioning presents ...	2005	16255526
variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the framingham heart study.	to examine the association between variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in men and women.	2005	16269961
comparative infectivity of babesia divergens and a zoonotic babesia divergens-like parasite in cattle.	babesia divergens-like parasites identified in human babesiosis cases in missouri and kentucky and in eastern cottontail rabbits (sylvilagus floridanus) on nantucket island, massachusetts, share identical small subunit ribosomal rna gene sequences. this sequence is 99.8% identical to that of babesia divergens, suggesting that the u.s. parasite may be b. divergens, a causative agent of human and bovine babesiosis in europe. holstein-friesian calves were inoculated with cultured nantucket island b ...	2005	16282295
aligning systems to create full-service schools: the boston experience, so far.	leaders of full-service schools in boston seek to expand the number and increase the impact of boston's full-service schools, catalyzing a realignment of public resources and an expansion of private investment. the full-service schools roundtable, led by a dynamic staff and supported by the mayor and the superintendent of schools, is a steadily growing coalition of educators, public agencies, human service providers, and community leaders. challenges for the roundtable are to build the public wi ...	2005	16315519
immigration policies increase south asian immigrant women's vulnerability to intimate partner violence.	to explore forms of immigration-related partner abuse and examine the association of such abuse and immigration status with physical and sexual intimate partner violence (ipv) among south asian women residing in greater boston.	2005	16845767
genotype-by-sex interaction in the regulation of high-density lipoprotein: the framingham heart study.	low levels of high-density lipoprotein (hdl) are widely documented as a risk factor for cardiovascular disease (cvd). furthermore, there is marked sexual dimorphism in both hdl levels and the prevalence of cvd. however, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. we examined the evidence for genotype-by-sex effects on hdl in a longitudinal sample of 1562 participants from 330 families in the framingham heart study at three times points correspon ...	2005	16715837
transcendent pluralism and the influence of nursing testimony on environmental justice legislation.	environmental justice is an important issue affecting health disparities. using the framework of transcendent pluralism, this article describes nursing actions and research in a legislative coalition for an environmental justice bill. two descriptive studies are conducted: a focus group with six legislative aides and an evaluation of a nursing presentation given to 10 massachusetts state legislators. pretest and posttest results showed a small but significant increase in the legislators' disposi ...	2005	16443961
human cell mutagens in respirable airborne particles from the northeastern united states. 2. quantification of mutagens and other organic compounds.	few reports have characterized mutagenic compounds in respirable airborne particles (<2.5 micrometers in diameter; pm2.5) collected at different sites on a regional scale (hundreds of km). previously, we reported differences in the human (h1a1v2) cell mutagenicity of whole and fractionated organic extracts of pm2.5 samples collected in boston, ma, rochester, ny, and quabbin reservoir, a rural site in western ma. herein we describe the analysis of mutagens and other organic compounds in these sam ...	2005	16475335
the 50th anniversary of the first successful human organ transplant.		2005	16524047
[progress on oecd chemicals programme (7)--siam 15 in boston, 2002].	the 15th screening information data set (sids) initial assessment meeting (siam 15) was held in boston, usa. the initial assessment documents of twelve substances at siam 15 (cas numbers: 79-39-0, 88-60-8, 92-70-6, 102-76-1, 110-83-8, 135-19-3, 7647-01-0, 8007-18-9, 10043-52-4, 11070-44-3, 25321-09-9, 68186-90-3) were submitted by the japanese government with or without the international council of chemical associations (icca) and all of them on the human health effect parts were agreed at the m ...	2005	16541752