Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| could the health decline of prehistoric california indians be related to exposure to polycyclic aromatic hydrocarbons (pahs) from natural bitumen? | background: the negative health effects of polycyclic aromatic hydrocarbons (pahs) are well established for modern human populations, but have so far not been studied in prehistoric contexts. pahs are the main component of fossil bitumen, a naturally occurring material used by past societies such as california's chumash indians as an adhesive, as a waterproofing agent, and for medicinal purposes. the rich archaeological and ethnohistoric record of the coastal chumash suggests that they were expo ... | 2011 | 21596651 |
| mortality among antiretroviral-eligible patients in an urban public clinic. | among 1651 antiretroviral therapy (art)-eligible patients attending an urban united states hiv clinic, four-year mortality was 10.0% in 2000-2004 and 11.0% in 2005-2009. despite universal art availability, only 72 (42%) of 172 patients who died, compared to 69% of survivors, ever achieved an hiv viral load <400 copies/mm. leading causes of death were aids (56%), violence/overdose (16%), and pulmonary disease (6%). disadvantaged sub-populations in the developed world can experience high mortality ... | 2011 | 21602697 |
| genetic characterization of swine influenza viruses (h3n2) isolated from minnesota in 2006-2007. | triple-reassortant (tr) h3n2 swine influenza viruses (siv) are a major cause of respiratory disease in swine worldwide, causing considerable morbidity and mortality. continuous surveillance of circulating siv strains is imperative for effective control and prediction of new emerging strains with interspecies transmission potential. the current study characterized siv isolates from commercial swine population in usa (2006-2007). nine isolates were completely sequenced, and the molecular evolution ... | 2011 | 21603982 |
| human jamestown canyon virus infection --- montana, 2009. | jamestown canyon virus (jcv) is a mosquito-borne zoonotic pathogen belonging to the california serogroup of bunyaviruses. although jcv is widely distributed throughout temperate north america, reports of human jcv infection in the united states are rare. this is the first report of human jcv infection detected in montana, one of only 15 cases reported in the united states since 2004, when jcv became reportable. on may 26, 2009, a man aged 51 years with no travel history outside of montana went t ... | 2011 | 21617630 |
| terrestrial sources homogenize bacterial water quality during rainfall in two urbanized watersheds in santa barbara, ca. | microbiological contamination from runoff is a human health concern in urbanized coastal environments, but the contamination sources are often unknown. this study quantified fecal indicator bacteria and compared the distributions of human-specific genetic markers and bacterial community composition during dry and wet weather in urban creeks draining two neighboring watersheds in santa barbara, ca. in a prior study conducted during exclusively dry weather, the creeks were contaminated with human ... | 2011 | 21617896 |
| "man-ing" up and getting drunk: the role of masculine norms, alcohol intoxication and alcohol-related problems among college men. | compared to college women, college men face elevated risks for problematic drinking and negative alcohol-related consequences. these risks highlight the critical need to investigate gender issues and risk factors contributing to intoxication and related problems among men. theoretical models suggest that conforming to masculine norms or the beliefs and expectations of what it means to be a man, may help explain patterns of problematic drinking among men. the current study advances the literature ... | 2011 | 21620570 |
| serum metalloproteinases mmp-2, mmp-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation. | objective: many vascular surgeons construct arteriovenous fistulas (avfs) for hemodialysis access as the primary choice access. a significant number of avfs fail to mature, however, leading to patient frustration and repeated operations. metalloproteinase (mmp) activity, particularly mmp-2 and mmp-9, may be important for avf maturation. we therefore sought to identify whether serum mmp levels could serve as a biomarker for predicting future successful avf maturation. methods: blood was collected ... | 2011 | 21620625 |
| evaluation of ammonia, human sweat, and bovine blood as attractants for the female canyon fly, fannia conspicua (diptera: muscidae), in southern california. | human sweat, liquid ammonia, and bovine blood are known to be attractive to some hematophagous flies. these materials were evaluated with and without carbon dioxide (co(2) ) for their ability to increase capture of female "canyon flies" (fannia conspicua malloch) using cdc-type suction traps (without light). ammonia acted synergistically with co(2) to increase trap catch 89.9% over co(2) alone. there was no synergistic effect of human sweat or bovine blood with co(2) . in the absence of co(2) , ... | 2011 | 21635641 |
| takeru higuchi, the man and the scientist. | madison (united states), december 7th 1941. it is early in the morning. takeru higuchi is listening to the radio when the programme is suddenly interrupted: part of the american naval fleet has just been destroyed in an air-raid on pearl harbour. for the united states, their involvement in the world war is now inevitable. for takeru higuchi, the son of japanese immigrants, this was the beginning of an inner struggle. as a student of physical chemistry at the university of wisconsin, he had recei ... | 2011 | 21640808 |
| circulating angiopoietins-1 and -2, angiopoietin receptor tie-2 and vascular endothelial growth factor-a as biomarkers of acute myocardial infarction: a prospective nested case-control study. | angiogenesis is up-regulated in myocardial ischemia. however, limited data exist assessing the value of circulating angiogenic biomarkers in predicting future incidence of acute myocardial infarction (ami). our aim was to examine the association between circulating levels of markers of angiogenesis with risk of incident acute myocardial infarction (ami) in men and women. | 2011 | 21672190 |
| west nile virus disease and other arboviral diseases --- united states, 2010. | arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. since west nile virus (wnv) was first detected in the western hemisphere in 1999, it has become the leading cause of neuroinvasive arboviral disease in the united states. however, several other arboviruses continue to cause sporadic cases and seasonal outbreaks of neuroinvasive disease (i.e., meningitis, encephalitis, or acute flaccid paralysis). this report summarizes su ... | 2011 | 21814163 |
| do frogs get their kicks on route 66? continental u.s. transect reveals spatial and temporal patterns of batrachochytrium dendrobatidis infection. | the chytrid fungus batrachochytrium dendrobatidis (bd) has been devastating amphibians globally. two general scenarios have been proposed for the nature and spread of this pathogen: bd is an epidemic, spreading as a wave and wiping out individuals, populations, and species in its path; and bd is endemic, widespread throughout many geographic regions on every continent except antarctica. to explore these hypotheses, we conducted a transcontinental transect of united states department of defense ( ... | 2011 | 21811576 |
| the oncofetal protein imp3: a novel molecular marker to predict aggressive meningioma. | context.-one of the major clinical challenges is to predict recurrence of meningioma. recently, we have found that imp3, an oncofetal rna-binding protein, is a biomarker to predict aggressive tumors. objective.-to investigate whether imp3 can be used as a new biomarker to predict the recurrence and overall survival of patients with meningiomas. design.-one hundred seven patients with primary meningiomas were investigated for expression of imp3 by immunohistochemistry and whether expression of th ... | 2011 | 21809995 |
| governing change: land-use change and the prevention of nonpoint source pollution in the north coastal basin of california. | many rural areas in the united states and throughout much of the postindustrial world are undergoing significant ecological, socioeconomic, and political transformations. the migration of urban and suburban dwellers into rural areas has led to the subdivision of large tracts of land into smaller parcels, which can complicate efforts to govern human-environmental problems. non-point source (nps) pollution from private rural lands is a particularly pressing human-environmental challenge that may b ... | 2011 | 21805381 |
| early warning system for west nile virus risk areas, california, usa. | the dynamic continuous-area space-time (dycast) system is a biologically based spatiotemporal model that uses public reports of dead birds to identify areas at high risk for west nile virus (wnv) transmission to humans. in 2005, during a statewide epidemic of wnv (880 cases), the california department of public health prospectively implemented dycast over 32,517 km2 in california. daily risk maps were made available online and used by local agencies to target public education campaigns, surveill ... | 2011 | 21801622 |
| determinants of serum polybrominated diphenyl ether (pbde) levels among pregnant women in the chamacos cohort. | we measured levels of 10 polybrominated diphenyl ether (pbde) congeners in serum collected during pregnancy and at delivery from 416 pregnant, predominantly immigrant, women living in monterey county, ca. the most frequently detected congeners were bde-47, -99, -100, and -153, all components of the penta mixture, detected in >97% of samples. we used multivariable regression models to examine factors associated with exposure to individual pbde congeners as well as their total summed concentration ... | 2011 | 21793581 |
| sewage exfiltration as a source of storm drain contamination during dry weather in urban watersheds. | separating storm drains and sanitary sewers is expected to control sewage pollution, for example from combined sewer overflows, and to reduce excessive stormwater flow to wastewater treatment plants. however, sewage contamination has been found in municipal separate storm drain systems in urban areas during dry weather flow. to determine if transmission of sewage is occurring from leaking sanitary sewers directly to leaking separated storm drains, field experiments were performed in three waters ... | 2011 | 21786744 |
| application of an integrated community analysis approach for microbial source tracking in a coastal creek. | high fecal indicator bacterial (fib) concentrations signal urban coastal water quality impairments that can threaten public health. however fib (total and fecal coliform plus enterococcus sp.) are not specific to human waste and thus microbial source tracking (mst) is employed to assess public health risks and remediation alternatives. currently, water quality diagnosis requires several simultaneous mst assays. relatively unexplored is a community analysis approach for mst where the overall micr ... | 2011 | 21786742 |
| [immunogenicity of inactivated subunit adsorbed monovalent vaccine against influenza a/california/7/2009 (h1n1) strain]. | the immunogenicity of pandeflu subunit vaccine against influenza a/california/7/2009 (h1n1) was evaluated in 70 healthy volunteers aged 18 to 60 years. the vaccine was intramuscularly injected twice at an interval of 28 days. each dose (0.5 ml) contains a(hin1) influenza virus hemagglutinin (15 +/- 2.2 microg), aluminum hydroxide (denmark) (0.475 +/- 0.075 microg), and the preservative thiomerosal (merthiolate) (50 +/- 7.5 microg). the level of antibodies was determined in the microneutralizatio ... | 2011 | 21786622 |
| genome-wide association study of the child behavior checklist dysregulation profile. | a potentially useful tool for understanding the distribution and determinants of emotional dysregulation in children is a child behavior checklist profile, comprising the attention problems, anxious/depressed, and aggressive behavior clinical subscales (cbcl-dp). the cbcl-dp indexes a heritable trait that increases susceptibility for later psychopathology, including severe mood problems and aggressive behavior. we have conducted a genome-wide association study of the cbcl-dp in children with att ... | 2011 | 21784300 |
| assessing allergenic fungi in house dust by floor wipe sampling and quantitative pcr. | in the present study, we modified an existing surface wipe sampling method for lead and other heavy metals to create a protocol to collect fungi in floor dust followed by real-time quantitative pcr (qpcr)-based detection. we desired minimal inconvenience for participants in residential indoor environmental quality and health studies. accuracy, precision, and method detection limits (mdls) were investigated. overall, mdls ranged from 0.6-25 cell/cm(2) on sampled floors. overall measurement precis ... | 2011 | 21767317 |
| cost-effectiveness of targeted human immunodeficiency virus screening in an urban emergency department. | academic emergency medicine 2011; 18:745-753 © 2011 by the society for academic emergency medicine abstract: objectives: although targeted screening of patients at high risk for human immunodeficiency virus (hiv) infection in the emergency department (ed) improves patient outcomes and may prevent hiv transmission, ed-based screening programs incur additional costs and have thus not been widely scaled up. the objective of this study was to evaluate the cost-effectiveness of ed-based targeted hiv ... | 2011 | 21762236 |
| smoking in top-grossing movies --- united states, 2010. | the national cancer institute has concluded that studies indicate a causal relationship between exposure to depictions of smoking in movies and youth smoking initiation. adolescents in the top quartile of exposures to onscreen tobacco incidents have been found to be approximately twice as likely to begin smoking as those in the bottom quartile. the 2010 u.s. department of health and human services strategic plan to reduce tobacco use includes reducing youth exposure to onscreen smoking. to monit ... | 2011 | 21753743 |
| basic subsistence needs and overall health among human immunodeficiency virus-infected homeless and unstably housed women. | some gender differences in the progression of human immunodeficiency virus (hiv) infection have been attributed to delayed treatment among women and the social context of poverty. recent economic difficulties have led to multiple service cuts, highlighting the need to identify factors with the most influence on health in order to prioritize scarce resources. the aim of this study was to empirically rank factors that longitudinally impact the health status of hiv-infected homeless and unstably ho ... | 2011 | 21749972 |
| the incidence of hepatosplenic t-cell lymphoma in a large managed care organization, with reference to anti-tumor necrosis factor therapy, northern california, 2000-2006. | background: hepatosplenic t-cell lymphoma (hstcl), a rare and rapidly progressive subtype of peripheral t-cell lymphoma, has been reported following tnf-+¦-blocker therapy. to better understand this relationship, we conducted an epidemiologic study in the kaiser permanente membership. methods: the retrospective cohort study was conducted among northern california members of all ages. the kaiser permanente cancer registry, supplemented with review of medical charts and pathology slides, was used ... | 2011 | 21823196 |
| fluorescence in situ hybridization and k-ras analyses improve diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses. | objectives:: endoscopic ultrasound (eus)-guided fine-needle aspiration (fna) is the main diagnostic modality for pancreatic mass lesions. however, cytology is often indeterminate, leading to repeat fnas and delay in care. here, we evaluate whether combining routine cytology with fluorescence in situ hybridization (fish) and k-ras/p53 analyses improves diagnostic yield of pancreatic eus-fna. methods:: fifty eus-fnas of pancreatic masses in 46 patients were retrospectively analyzed. mean follow-up ... | 2011 | 21705950 |
| strawberry anthocyanin and its association with postprandial inflammation and insulin. | the present study investigates the effect of strawberry antioxidants in beverage form on meal-induced postprandial inflammatory and insulin responses in human subjects. overweight adults (n 24) consumed a high-carbohydrate, moderate-fat meal (hcfm) accompanied by either a strawberry or a placebo beverage in a cross-over design. postprandial changes in plasma anthocyanins, their metabolites, insulin, glucose and inflammatory markers were assessed for 6-áh. the postprandial concentrations of pelar ... | 2011 | 21736853 |
| reconciling incongruous qualitative and quantitative findings in mixed methods research: exemplars from research with drug using populations. | mixed methods research is increasingly being promoted in the health sciences as a way to gain more comprehensive understandings of how social processes and individual behaviours shape human health. mixed methods research most commonly combines qualitative and quantitative data collection and analysis strategies. often, integrating findings from multiple methods is assumed to confirm or validate the findings from one method with the findings from another, seeking convergence or agreement between ... | 2011 | 21680168 |
| nidicolous ticks of small mammals in anaplasma phagocytophilum-enzootic sites in northern california. | ixodes spp. tick-borne zoonotic diseases are present across the holarctic in humans, domestic animals, and wildlife. small mammals are reservoirs for the rickettsial pathogen anaplasma phagocytophilum and tick vectors may include catholic-feeding bridge vectors as well as host-specialist or nidicolous ticks. far western north american communities in which a. phagocytophilum is maintained are complex ecologically, with multiple reservoir host and tick species, multiple strains of the bacterial pa ... | 2011 | 21686062 |
| histologic and molecular analyses of colonic perineurial-like proliferations in serrated polyps: perineurial-like stromal proliferations are seen in sessile serrated adenomas. | colonic perineuriomas are recently described benign mucosal polyps that are composed of a bland spindle cell proliferation surrounding crypts that often demonstrate hyperplastic/serrated epithelial changes. however, the origin of this unique stromal proliferation is still unclear, and the association with serrated polyps, including sessile serrated adenomas, has not been fully described. we evaluated the pathologic and molecular features of colonic polyps associated with perineurial-like prolife ... | 2011 | 21836484 |
| sources and fate of salmonella and fecal indicator bacteria in an urban creek. | this research aimed to understand the sources and fate of salmonella and fecal bacteria in urban surface waters. an urban creek (san pedro creek, california, usa) that had unusually high levels of salmonella and fecal bacteria relative to other nearby waterbodies was chosen as a model field site. state of the art microbiological methods were used in concert with modeling to investigate salmonella and fecal bacteria sources, and determine field-relevant dark inactivation and photoinactivation rat ... | 2011 | 21687857 |
| fine particulate matter from urban ambient and wildfire sources from california's san joaquin valley initiate differential inflammatory, oxidative stress, and xenobiotic responses in human bronchial epithelial cells. | environmental particulate matter (pm) exposure has been correlated with pathogenesis of acute airway inflammatory disease such as asthma and copd. pm size and concentration have been studied extensively, but the additional effects of particulate components such as biological material, transition metals, and polycyclic aromatic hydrocarbons could also impact initial disease pathogenesis. in this study, we compared urban ambient particulate matter (apm) collected from fresno, california with wildf ... | 2011 | 21703343 |
| distribution and phylogenetic comparisons of a novel mosquito flavivirus sequence present in culex tarsalis mosquitoes from western canada with viruses isolated in california and colorado. | in a previous study, a new flavivirus genome sequence was identified in culex tarsalis mosquitoes obtained in alberta, canada and was shown to be genetically related to but distinct from members of the insect-specific flaviviruses. nonstructural protein 5-encoding sequences amplified from cx. tarsalis pools from western canada have shown a high similarity to genome sequences of novel flaviviruses isolated from mosquitoes in california and colorado. despite wide distribution of this virus, design ... | 2011 | 21734143 |
| role of the gender-linked norm of toughness in the decision to engage in treatment for depression. | given their prevalence and persuasive power in our culture, gender norms--commonly described as socially reinforced, learned expectations of what it means to be a man or a woman--likely contribute to sex differences in service utilization for depression. this study investigated whether sex differences in toughness, a gender-linked norm characterized by a desire to hide pain and maintain independence, were associated with a preference to wait for depression to resolve on its own without active pr ... | 2011 | 21724786 |
| field evaluation of a new plastic film (vapor safe) to reduce fumigant emissions and improve distribution in soil. | preplant soil fumigation is an important pest management practice in coastal california strawberry production regions. potential atmospheric emissions of fumigants from field treatment, however, have drawn intensive environmental and human health concerns; increasingly stringent regulations on fumigant use have spurred research on low-emission application techniques. the objectives of this research were to determine the effects of a new low-permeability film, commonly known as totally impermeabl ... | 2011 | 21712589 |
| costs of necrotizing enterocolitis and cost-effectiveness of exclusively human milk-based products in feeding extremely premature infants. | abstract objective: this study evaluated the cost-effectiveness of a 100% human milk-based diet composed of mother's milk fortified with a donor human milk-based human milk fortifier (hmf) versus mother's milk fortified with bovine milk-based hmf to initiate enteral nutrition among extremely premature infants in the neonatal intensive care unit (nicu). methods: a net expected costs calculator was developed to compare the total nicu costs among extremely premature infants who were fed either a bo ... | 2011 | 21718117 |
| acrylamide formation in almonds (prunus dulcis): influences of roasting time and temperature, precursors, varietal selection, and storage. | acrylamide is a probable human carcinogen that is found in many roasted and baked foods. this paper describes two sensitive and reliable lc-(esi)ms/ms methods for the analysis of (1) acrylamide and (2) common acrylamide precursors (i.e., glucose, fructose, asparagine, and glutamine) in raw and roasted almonds. these methods were used to evaluate the impact of roasting temperatures (between 129 and 182 °c) and times on acrylamide formation. controlling the roasting temperature at or below 146 °c ... | 2011 | 21721575 |
| evidence of neutron leakage at the fukushima nuclear plant from measurements of radioactive 35s in california. | a recent earthquake and the subsequent tsunami have extensively damaged the fukushima nuclear power plant, releasing harmful radiation into the environment. despite the obvious implication for human health and the surrounding ecology, there are no quantitative estimates of the neutron flux leakage during the weeks following the earthquake. here, using measurements of radioactive (35)s contained in sulfate aerosols and so(2) gas at a coastal site in la jolla, california, we show that nearly 4-á+ù ... | 2011 | 21844372 |
| determinants of polycyclic aromatic hydrocarbon levels in house dust. | estimation of human exposures to polycyclic aromatic hydrocarbons (pahs) is often desired for the epidemiological studies of cancer. one way to obtain information about indoor levels of pahs is to measure these chemicals in house dust. in this study, we evaluated the predictive value of self-reported and geographic data for estimating measured levels of nine pahs in house dust from 583 households in the northern california childhood leukemia study (nccls). using multivariable linear regression m ... | 2011 | 20040932 |
| cyp2c9 allele frequency differences between populations of mexican-mestizo, mexican-tepehuano, and spaniards. | earlier we had found that the cyp2c9*2 allelic frequency was lower in mexican-americans living in california than in spaniards (sp). this was assumed to be related to the low cyp2c9*2 and *3 allele frequencies in orientals. this study was therefore aimed at analyzing whether there were also differences in cyp2c9 allele frequencies between mexican-tepehuanos (mt) and mexican-mestizos (mm) living in northwestern mexico and sp. the cyp2c9*2 frequency was expected to be lower in the indigenous mt th ... | 2011 | 20458343 |
| linkage scan of nicotine dependence in the university of california, san francisco (ucsf) family alcoholism study. | nicotine dependence has been shown to represent a heritable condition, and several research groups have performed linkage analysis to identify genomic regions influencing this disorder though only a limited number of the findings have been replicated. | 2011 | 20594377 |
| metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. | the human oropharynx is a reservoir for many potential pathogens, including streptococcal species that cause endocarditis. although oropharyngeal microbes have been well described, viral communities are essentially uncharacterized. we conducted a metagenomic study to determine the composition of oropharyngeal dna viral communities (both phage and eukaryotic viruses) in healthy individuals and to evaluate oropharyngeal swabs as a rapid method for viral detection. viral dna was extracted from 19 p ... | 2011 | 20547834 |
| a regional mass balance of methylmercury in san francisco bay, california, usa. | the san francisco bay (california, usa) is a water body listed as impaired because of hg contamination in sport fish for human consumption, as well as possible effects on resident wildlife. a legacy of hg mining in local watersheds and hg used in au mining in the sierra nevada (usa) has contributed to contamination seen in the bay, with additional more recent and ongoing inputs from various sources. methylmercury is the species of hg most directly responsible for contamination in biota, so bette ... | 2011 | 20872899 |
| high antipredatory efficiency of insular lizards: a warning signal of excessive specimen collection? | we live-captured lizards on islands in the gulf of california and the baja california peninsula mainland, and compared their ability to escape predation. contrary to expectations, endemic lizard species from uninhabited islands fled from humans earlier and more efficiently than those from peninsular mainland areas. in fact, 58.2% (n=146) of the lizards we tried to capture on the various islands escaped successfully, while this percentage was only 14.4% (n=160) on the peninsular mainland. separat ... | 2011 | 22216244 |
| defining asbestos: differences between the built and natural environments. | asbestos - while most think they know what this material is, few understand the current issues surrounding it. few would also realize that asbestos is the form of a mineral, and even fewer would know that there are different types of asbestos, that not only had different industrial applications, but pose differing health risks when inhaled. asbestos was in wide-spread use mid-last century in many consumer products, and no doubt saved thousands of lives, but by the latter part of last century con ... | 2010 | 21138165 |
| mercury contamination in three species of anuran amphibians from the cache creek watershed, california, usa. | fish and wildlife may bioaccumulate mercury (hg) to levels that adversely affect reproduction, growth, and survival. sources of hg within the cache creek watershed in northern california have been identified, and concentrations of hg in invertebrates and fish have been documented. however, bioaccumulation of hg by amphibians has not been evaluated. in this study, adult and juvenile american bullfrogs (lithobates catesbeianus) and foothill yellow-legged frogs (rana boylii), adult northern pacific ... | 2010 | 19353298 |
| response of melon fly (diptera: tephritidae) to weathered splat-spinosad-cue-lure. | studies were conducted in hawaii to measure attraction of male melon fly, bactrocera cucurbitae (coquillett) (diptera: tephritidae), to splat-cue-lure (c-l) and splat-melo-lure (m-l) (raspberry ketone formate). direct field comparisons of splat-c-l and splat-m-l at low (5%) and high (20%) concentrations indicated few differences in attraction over a 15-wk period. subsequently, only splat-spinosad-c-l (5%) was compared with min-u-gel c-l with naled (standard used in california) in weathering stud ... | 2010 | 21061958 |
| flt3 mutation incidence and timing of origin in a population case series of pediatric leukemia. | mutations in flt3 result in activated tyrosine kinase activity, cell growth stimulation, and a poor prognosis among various subtypes of leukemia. the causes and timing of the mutations are not currently known. we evaluated the prevalence and timing of origin of flt3 mutations in a population series of childhood leukemia patients from northern california. | 2010 | 20875128 |
| the saga of our times-government inaction on self-referral: are we getting closer to a solution? | 2010 | 20889099 | |
| probing transplant and living donor candidates about their participation in organ vending. | the selling of human organs for transplant is illegal in the united states and in most countries; however, such transactions still occur. transplant hospitals and their personnel have multiple ethical duties, including (1) protecting the safety of their living donors and transplant recipients and (2) protecting the integrity of living donation and transplantation as clinical practices. to date, few psychosocial screening tools exist that pertain specifically to a person's risk or intent of pursu ... | 2010 | 20929116 |
| association of st2 levels with cardiac structure and function and mortality in outpatients. | st2, an interleukin-1 receptor family member up-regulated in the setting of cardiomyocyte strain, has prognostic value in patients with acute myocardial infarction, chronic severe heart failure, and acute heart failure. the predictive value of st2 levels in outpatients is unknown. we studied the clinical and echocardiographic correlates of st2 levels and evaluated their prognostic use in outpatients referred for echocardiograms. | 2010 | 20934567 |
| study protocol: the adherence and intensification of medications (aim) study--a cluster randomized controlled effectiveness study. | many patients with diabetes have poor blood pressure (bp) control. pharmacological therapy is the cornerstone of effective bp treatment, yet there are high rates both of poor medication adherence and failure to intensify medications. successful medication management requires an effective partnership between providers who initiate and increase doses of effective medications and patients who adhere to the regimen. | 2010 | 20939913 |
| effects of an invasive forest pathogen on abundance of ticks and their vertebrate hosts in a california lyme disease focus. | invasive species, including pathogens, can have important effects on local ecosystems, including indirect consequences on native species. this study focuses on the effects of an invasive plant pathogen on a vertebrate community and ixodes pacificus, the vector of the lyme disease pathogen (borrelia burgdorferi) in california. phytophthora ramorum, the causative agent of sudden oak death, is a non-native pathogen killing trees in california and oregon. we conducted a multi-year study using a grad ... | 2010 | 20941513 |
| asian ethnicity and breast cancer subtypes: a study from the california cancer registry. | the distribution of breast cancer molecular subtypes has been shown to vary by race/ethnicity, highlighting the importance of host factors in breast tumor biology. we undertook the current analysis to determine population-based distributions of breast cancer subtypes among six ethnic asian groups in california. we defined immunohistochemical (ihc) surrogates for each breast cancer subtype among chinese, japanese, filipina, korean, vietnamese, and south asian patients diagnosed with incident, pri ... | 2010 | 20957431 |
| virology, epidemiology, pathogenesis, and control of enterovirus 71. | first isolated in california, usa, in 1969, enterovirus 71 (ev71) is a major public health issue across the asia-pacific region and beyond. the virus, which is closely related to polioviruses, mostly affects children and causes hand, foot, and mouth disease with neurological and systemic complications. specific receptors for this virus are found on white blood cells, cells in the respiratory and gastrointestinal tract, and dendritic cells. being an rna virus, ev71 lacks a proofreading mechanism ... | 2010 | 20961813 |
| pilot study of the antiplatelet effect of increased clopidogrel maintenance dosing and its relationship to cyp2c19 genotype in patients with high on-treatment reactivity. | the objective of this study was to evaluate the antiplatelet effect of clopidogrel 150 mg/day in patients with high on-treatment reactivity (otr) and to further assess this effect according to cyp2c19 genotype. | 2010 | 20965456 |
| the relatedness of hiv epidemics in the united states-mexico border region. | phylogeography can improve the understanding of local and worldwide hiv epidemics, including the migration of subepidemics across national borders. we analyzed hiv-1 sequences sampled from mexico and san diego, california to determine the relatedness of these epidemics. we sampled the hiv epidemics in (1) mexico by downloading all publicly available hiv-1 pol sequences from antiretroviral-naive individuals in genbank (n = 100) and generating similar sequences from cohorts of injection drug users ... | 2010 | 20977301 |
| ultrafine particle concentrations and exposures in seven residences in northern california. | human exposures to ultrafine particles (ufp) are poorly characterized given the potential associated health risks. residences are important sites of exposure. to characterize residential exposures to ufp in some circumstances and to investigate governing factors, seven single-family houses in california were studied during 2007-2009. during multiday periods, time-resolved particle number concentrations were monitored indoors and outdoors and information was acquired concerning occupancy, source- ... | 2010 | 21029183 |
| longitudinal prevalence and molecular typing of escherichia coli o157:h7 by use of multiple-locus variable-number tandem-repeat analysis and pulsed-field gel electrophoresis in fecal samples collected from a range-based herd of beef cattle in california. | to evaluate seasonal patterns and risk factors for escherichia coli o157:h7 in feces in a beef cattle herd and determine strain diversity and transition in e coli over time by use of multiple-locus variable-number tandem-repeat analysis (mlva) and pulsed-field gel electrophoresis (pfge). | 2010 | 21034325 |
| sentinel chicken seroconversions track tangential transmission of west nile virus to humans in the greater los angeles area of california. | in los angeles, california, west nile virus (wnv) has followed a pattern of emergence, amplification, subsidence, and resurgence. a time series cross-correlation analysis of human case counts and sentinel chicken seroconversions revealed temporal concordance indicating that chicken seroconversions tracked tangential transmission of wnv from the basic passeriform-culex amplification cycle to humans rather than antecedent enzootic amplification. sentinel seroconversions provided the location and t ... | 2010 | 21036853 |
| children hospitalized with 2009 novel influenza a(h1n1) in california. | to describe clinical and epidemiologic features of 2009 novel influenza a(h1n1) in children. | 2010 | 21041595 |
| the accuracy of noninvasive and continuous total hemoglobin measurement by pulse co-oximetry in human subjects undergoing hemodilution. | total hemoglobin (thb) is one the most frequently ordered laboratory measurements. pulse co-oximetry™ (masimo corp., irvine, ca) is a multi-wavelength spectrophotometric method for noninvasive and continuous hemoglobin monitoring (sphb). in this study, we evaluated the accuracy of sphb compared with laboratory co-oximeter measurement of thb from arterial blood samples in 20 healthy volunteer subjects undergoing hemodilution. | 2010 | 21048100 |
| clinical signs, imaging features, neuropathology, and outcome in cats and dogs with central nervous system cryptococcosis from california. | cryptococcus spp. is a fungal pathogen with a predilection for the central nervous system (cns). | 2010 | 21054543 |
| 'gay boy talk' meets 'girl talk': hiv risk assessment assumptions in young gay men's sexual health communication with best friends. | young adults, particularly young gay men (ygm), are vulnerable to human immunodeficiency virus (hiv). yet, little is known about how ygm discuss sexual health issues with their friends ('gay boy talk'). we conducted semi-structured interviews with ygm and their best friends (11 ygm/ygm dyads and 13 ygm/heterosexual female dyads). in this paper, we examine risk assessment assumptions conveyed within ygm's communication about sexual health with their friends and how, if at all, the sexual scripts ... | 2010 | 21059803 |
| 2009 pandemic influenza a (h1n1) virus infection in postpartum women in california. | the objective of the study was to characterize severe illness because of the 2009 pandemic influenza a (h1n1) infection in postpartum women. | 2010 | 21074132 |
| infant botulism in australia: availability of human botulinum antitoxin for treatment. | we report the first australian case of treatment of infant botulism with a human botulinum antitoxin developed in the united states by the california department of public health. our patient's clinical improvement was rapid, and although the product is expensive, cost-analysis supports the economical viability of its use. in future cases of suspected infant botulism, we recommend that australian clinicians promptly obtain and administer this antitoxin to their patient. | 2010 | 21077820 |
| higher levels of gata3 predict better survival in women with breast cancer. | the gata family members are zinc finger transcription factors involved in cell differentiation and proliferation. gata3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. our goal was to validate the ability of gata3 expression to predict survival in breast cancer patients. protein expression of gata3 was analyzed on a high-density tissue microarray consisting of 242 cases of breast cancer. we associated gata3 expression with p ... | 2010 | 21078439 |
| lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups. | breast cancer comprises clinically distinct subtypes, but most risk statistics consider breast cancer only as a single entity. to estimate subtype-specific lifetime breast cancer risks, we took advantage of population-based data for which information regarding tumor expression of estrogen receptor (er), progesterone receptor (pr) and her2/neu (her2) was newly available. | 2010 | 21092082 |
| economic conditions predict prevalence of west nile virus. | understanding the conditions underlying the proliferation of infectious diseases is crucial for mitigating future outbreaks. since its arrival in north america in 1999, west nile virus (wnv) has led to population-wide declines of bird species, morbidity and mortality of humans, and expenditures of millions of dollars on treatment and control. to understand the environmental conditions that best explain and predict wnv prevalence, we employed recently developed spatial modeling techniques in a re ... | 2010 | 21103053 |
| a multidisciplinary organ donor council and performance improvement initiative can improve donation outcomes. | the shortage of organs available for transplantation has become a national crisis. the department of health and human services established performance benchmarks for timely notification, donation after cardiac death (dcd), and conversion rates (total donors/eligible deaths) to guide organ procurement organizations and donor hospitals in their attempts to increase the number of transplantable organs. in january 2007, an organ donor council (odc) with an ongoing performance improvement case review ... | 2010 | 21105609 |
| vector-host interactions governing epidemiology of west nile virus in southern california. | southern california remains an important focus of west nile virus (wnv) activity, with persistently elevated incidence after invasion by the virus in 2003 and subsequent amplification to epidemic levels in 2004. eco-epidemiological studies of vectors-hosts-pathogen interactions are of paramount importance for better understanding of the transmission dynamics of wnv and other emerging mosquito-borne arboviruses. we investigated vector-host interactions and host-feeding patterns of 531 blood-engor ... | 2010 | 21118934 |
| nanotechnology and nanomaterials: toxicology, risk assessment, and regulations. | nanomaterials have very unique chemical and physical properties that suggest potential health hazards, but limited health and safety information exists for engineered nanomaterials. this review identifies a need for expanding efforts for addressing health and safety concerns in nanotechnology development and in nanotoxicology of engineered nanomaterials. the efforts include research to generate data for safety evaluation, toxicologic evaluation of potential human health effects, risk assessment ... | 2010 | 21121378 |
| pandemic (h1n1) 2009 infection in patients with hematologic malignancy. | to assess outcomes of patients with hematologic malignancy and pandemic (h1n1) 2009 infection, we reviewed cases during june-december 2009 at the university of california san francisco medical center. seventeen (63%) and 10 (37%) patients had upper respiratory tract infection (urti) and lower respiratory tract infection (lrti), respectively. cough (85%) and fever (70%) were the most common signs; 19% of patients had nausea, vomiting, or diarrhea. sixty-five percent of urti patients were outpatie ... | 2010 | 21122221 |
| gait-specific energetics contributes to economical walking and running in emus and ostriches. | a widely held assumption is that metabolic rate (ė(met)) during legged locomotion is linked to the mechanics of different gaits and this linkage helps explain the preferred speeds of animals in nature. however, despite several prominent exceptions, ė(met) of walking and running vertebrates has been nearly uniformly characterized as increasing linearly with speed across all gaits. this description of locomotor energetics does not predict energetically optimal speeds for minimal cost of transport ... | 2010 | 21123267 |
| pon1 and neurodevelopment in children from the chamacos study exposed to organophosphate pesticides in utero. | paraoxonase 1 (pon1) detoxifies oxon derivatives of some organophosphate (op) pesticides, and its genetic polymorphisms influence enzyme activity and quantity. we previously reported that maternal urinary concentrations of dialkyl phosphate (dap) metabolites, a marker of op pesticide exposure, were related to poorer mental development and maternally reported symptoms consistent with pervasive developmental disorder (pdd) in 2-year-olds participating in the center for the health assessment of mot ... | 2010 | 21126941 |
| a marginal structural model to estimate the causal effect of antidepressant medication treatment on viral suppression among homeless and marginally housed persons with hiv. | depression strongly predicts nonadherence to human immunodeficiency virus (hiv) antiretroviral therapy, and adherence is essential to maintaining viral suppression. this suggests that pharmacologic treatment of depression may improve virologic outcomes. however, previous longitudinal observational analyses have inadequately adjusted for time-varying confounding by depression severity, which could yield biased estimates of treatment effect. application of marginal structural modeling to longitudi ... | 2010 | 21135328 |
| modeled response of the west nile virus vector culex quinquefasciatus to changing climate using the dynamic mosquito simulation model. | climate can strongly influence the population dynamics of disease vectors and is consequently a key component of disease ecology. future climate change and variability may alter the location and seasonality of many disease vectors, possibly increasing the risk of disease transmission to humans. the mosquito species culex quinquefasciatus is a concern across the southern united states because of its role as a west nile virus vector and its affinity for urban environments. using established relati ... | 2010 | 20683620 |
| prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices (acip), 2010. | this report updates the 2009 recommendations by cdc's advisory committee on immunization practices (acip) regarding the use of influenza vaccine for the prevention and control of influenza (cdc. prevention and control of influenza: recommendations of the advisory committee on immunization practices [acip]. mmwr 2009;58[no. rr-8] and cdc. use of influenza a (h1n1) 2009 monovalent vaccine---recommendations of the advisory committee on immunization practices [acip], 2009. mmwr 2009;58:[no. rr-10]). ... | 2010 | 20689501 |
| cancer incidence in female cosmetologists and manicurists in california, 1988-2005. | health concerns have been pronounced for cosmetologists and manicurists, who are exposed daily to cosmetic products containing known or suspected human carcinogens and endocrine disruptors. in this retrospective cohort study, the authors used probabilistic record linkage between california's statewide cosmetology licensee and cancer surveillance files to identify newly diagnosed invasive cancers among female workforce members during 1988-2005. rate ratios and 95% confidence intervals for cancer ... | 2010 | 20693266 |
| epidemiology of ulcerative keratitis in northern california. | to determine the incidence and associated risk factors for ulcerative keratitis in northern california. | 2010 | 20697003 |
| human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories. | the optimal method to assess human epidermal growth factor receptor 2 (her2) status remains highly controversial. before reporting patient her2 results, american society of clinical oncology (asco)/college of american pathologists (cap) guidelines mandate that laboratories demonstrate ≥ 95% concordance to another approved laboratory or methodology. here, we compare central laboratory her2 assessed by fluorescence in situ hybridization (fish) and quantitative reverse transcriptase polymerase chai ... | 2010 | 20697093 |
| ozone, nitric acid, and ammonia air pollution is unhealthy for people and ecosystems in southern sierra nevada, california. | two-week average concentrations of ozone (o3), nitric acid vapor (hno3) and ammonia (nh3) were measured with passive samplers during the 2002 summer season across the central sierra nevada mountains, california, along the san joaquin river drainage. elevated concentrations of the pollutants were determined with seasonal means for individual sites ranging between 62 and 88 ppb for o3, 1.0-3.8 microg m(-3) for hno3, and 2.6-5.2 microg m(-3) for nh3. calculated o3 exposure indices were very high, r ... | 2010 | 20708832 |
| vein tissue expression of matrix metalloproteinase as biomarker for hemodialysis arteriovenous fistula maturation. | failure of arteriovenous fistula (avf) maturation is attributed to impaired vein remodeling. the purpose of this study is to identify whether vein matrix metalloproteinase (mmp) expression and activity is associated with avf maturation. patients with renal insufficiency undergoing surgery had their vein segments harvested and snap-frozen at time of avf construction. expression of mmp-2, mmp-9, membrane type-1 mmp (mt1-mmp), tissue inhibitor of metallopreoteinases type 2 (timp-2), and timp-4 were ... | 2010 | 20724289 |
| human virus and bacteriophage inactivation in clear water by simulated sunlight compared to bacteriophage inactivation at a southern california beach. | few quantitative data exist on human virus inactivation by sunlight and the relationship between human and indicator viruses under sunlit conditions. we investigated the effects of sunlight on human viruses (adenovirus type 2, poliovirus type 3) and bacteriophages (ms2, q-beta sp, fi, m13, prd1, phi-x174, and coliphages isolated from avalon bay, california). viruses were inoculated into phosphate buffered saline or seawater, exposed to a laboratory solar simulator for ≤12 h, and enumerated by do ... | 2010 | 20726507 |
| lipophilic statin use and risk of breast cancer subtypes. | statins are widely used and of high interest as potential chemopreventive agents for cancer. preclinical studies suggest that lipophilic statins have anticancer properties targeting hormone receptor (hr)-negative breast cancer. few epidemiologic studies have investigated the relationship between lipophilic statin use and risk for breast cancer, stratified by hr status. we conducted a large case-control study within kaiser permanente of northern california (kpnc) to determine whether chronic use ... | 2010 | 20729289 |
| cercarial dermatitis transmitted by exotic marine snail. | cercarial dermatitis (swimmer's itch) is caused by the penetration of human skin by cercariae of schistosome parasites that develop in and are released from snail hosts. cercarial dermatitis is frequently acquired in freshwater habitats, and less commonly in marine or estuarine waters. to investigate reports of a dermatitis outbreak in san francisco bay, california, we surveyed local snails for schistosome infections during 2005-2008. we found schistosomes only in haminoea japonica, an asian sna ... | 2010 | 20735918 |
| the property/privacy conundrum over human tissue. | this paper analyzes court rulings on tissue samples as property and critiques objections that have been raised to the recognition of dna samples as personal property. the cases are: moore v. regents of the university of california (1988, 1990), greenberg v. miami children's research institute (2003), and washington university v. catalona (2007). the paper argues that it is possible for the law to support both individual privacy and property rights in dna, recognizing nevertheless that some unres ... | 2010 | 20737193 |
| [swine-origin influenza h1n1/california--passions and facts]. | analysis of pandemic caused by swine influenza virus h1n1/california showed moderate virulence of this virus compared to pandemic viruses, which caused pandemics in 1918, 1957, and 1968. during seasonal influenza epidemic in countries of southern hemisphere (june-august 2009) despite on circulation of h1n1/california strain, epidemics was caused by human influenza viruses h3n2 and h1n1. it was concluded that strain h1n1/california could not be attributed to pandemic strains of influenza viruses. | 2010 | 20795393 |
| endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from fresno, california initiate human monocyte inflammatory responses mediated by reactive oxygen species. | in urban areas, a correlation between exposure to particulate matter (pm) from air pollution and increased cardiovascular morbidity and mortality has been observed. components of pm include bacterial contaminants, transition metals, salts, polycyclic aromatic hydrocarbons (pah), and carbonaceous material, which could interact with various cell types to produce systemic responses when inhaled. we examined the effects of pm collected from fresno, california on activation of human monocytes and the ... | 2010 | 20801209 |
| effect of estuarine wetland degradation on transport of toxoplasma gondii surrogates from land to sea. | the flux of terrestrially derived pathogens to coastal waters presents a significant health risk to marine wildlife, as well as to humans who utilize the nearshore for recreation and seafood harvest. anthropogenic changes in natural habitats may result in increased transmission of zoonotic pathogens to coastal waters. the objective of our work was to evaluate how human-caused alterations of coastal landscapes in california affect the transport of toxoplasma gondii to estuarine waters. toxoplasma ... | 2010 | 20802072 |
| who and where are the children yet to enroll in medicaid and the children's health insurance program? | kathleen sebelius, secretary of health and human services, has issued a challenge to enroll the millions of uninsured children eligible for public insurance in medicaid or the children's health insurance program (chip). this paper provides estimates of the rates at which children in the various states participated in these programs in 2008 as well as the number who were eligible for them but uninsured. according to our coverage estimates, an estimated 7.3 million children were uninsured on an av ... | 2010 | 20817690 |
| food web bioaccumulation model for polychlorinated biphenyls in san francisco bay, california, usa. | we document the development and application of a food web bioaccumulation model for polychlorinated biphenyls (pcbs) in san francisco bay, california, usa. the model calculates spatial distributions of pcb concentrations in a range of invertebrate, fish, avian, and mammalian organisms, including harbor seals, double-crested cormorants, and forster's terns. the performance of the model is evaluated against independent empirical pcb concentrations and shows a mean deviation between observed and mo ... | 2010 | 20821583 |
| effect of influenza vaccination on hospitalizations in persons aged 50 years and older. | to estimate influenza vaccine effectiveness (ve) in preventing hospitalizations in persons over 50 years of age. | 2010 | 20832494 |
| 500 patients in san diego might revolutionize care. | 2010 | 20550053 | |
| accuracy of influenza vaccination status in a computer-based immunization tracking system of a managed care organization. | influenza vaccine safety and effectiveness studies conducted using electronic medical records rely on accurate assessment of influenza vaccination status. however, influenza immunization in non-traditional settings (e.g., the workplace) may not be captured in patient immunization tracking systems. we compared influenza vaccination status from electronic records with self-reported vaccination status for five hundred and two 50-79 years olds enrolled in a large managed care organization. influenza ... | 2010 | 20554065 |
| perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. | hazardous air pollutants are plausible candidate exposures for autism spectrum disorders. they have been explored in recent studies for their role in the development of these disorders. | 2010 | 20562626 |
| brief communication: additional cases of maxillary canine-first premolar transposition in several prehistoric skeletal assemblages from the santa barbara channel islands of california. | this article identifies and discusses seven new cases of complete maxillary canine-premolar transposition in ancient populations from the santa barbara channel region of california. a high frequency of this tooth transposition has been previously documented within a single prehistoric cemetery on one of the channel islands. a total of 966 crania representing 30 local sites and about 7,000 years of human occupation were examined, revealing an abnormally high prevalence of this transposition trait ... | 2010 | 20564519 |
| mapping groundwater dependent ecosystems in california. | most groundwater conservation and management efforts focus on protecting groundwater for drinking water and for other human uses with little understanding or focus on the ecosystems that depend on groundwater. however, groundwater plays an integral role in sustaining certain types of aquatic, terrestrial and coastal ecosystems, and their associated landscapes. our aim was to illuminate the connection between groundwater and surface ecosystems by identifying and mapping the distribution of ground ... | 2010 | 20585640 |
| evaluation of the clinical performance of high-risk human papillomavirus testing for primary screening: a retrospective review of the southern california permanente medical group experience. | we investigated the potential impact of using the high-risk human papillomavirus (hpv) test as a primary screening tool for the detection of cervical cancer and its precursor lesions. | 2010 | 20592555 |
| α-synuclein gene may interact with environmental factors in increasing risk of parkinson's disease. | although of great interest and suggested in prior reports, possible α-synuclein (snca) gene-environment interactions have not been well investigated in humans. | 2010 | 20664293 |