Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| human papillomavirus infections in laryngeal cancer. | although the association and clinical significance of human papillomavirus (hpv) infections with a subset of head and neck cancers, particularly for oropharyngeal carcinoma, has recently been well documented, the involvement of hpv in laryngeal cancer has been inadequately evaluated. herein we review the currently known associations of hpv infections in diseases of the larynx and their potential for oncogenicity. using several methods of detection, hpv dna has been detected in benign (papillomat ... | 2011 | 20848441 |
| triggering of death receptor apoptotic signaling by human papillomavirus 16 e2 protein in cervical cancer cell lines is mediated by interaction with c-flip. | human papillomavirus (hpv) e2 gene disruption is one of the key features of hpv-induced cervical malignant transformation. though it is thought to prevent progression of carcinogenesis, the pro-apoptotic function of e2 protein remains poorly understood. this study shows that expression of hpv16 e2 induces apoptosis both in hpv-positive and -negative cervical cancer cell lines and leads to hyperactivation of caspase-8 and caspase-3. activation of these signaling factors is responsible for the obs ... | 2011 | 20882347 |
| adenocarcinoma in situ and associated human papillomavirus type distribution observed in two clinical trials of a quadrivalent human papillomavirus vaccine. | the primary objective of this report is to describe the detection of adenocarcinoma in situ (ais) and associated human papillomavirus (hpv) type distribution that was observed in the context of two phase 3 clinical trials of a quadrivalent hpv6/11/16/18 vaccine. in this intention-to-treat analysis, we include all women who had at least one follow-up visit postenrollment. healthy women (17,622) aged 15-26 with no history of hpv disease and a lifetime number of less than five sex partners (average ... | 2011 | 20949623 |
| immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments. | epidermolytic ichthyosis (ei) is a skin fragility disorder caused by mutations in genes encoding suprabasal keratins 1 and 10. while the aetiology of ei is known, model systems are needed for pathophysiological studies and development of novel therapies. | 2011 | 20977447 |
| cutaneous human papillomavirus-related immune reconstitution-associated disease in human immunodeficiency virus: an under-recognized phenomenon. | 2011 | 21039411 | |
| curcumin suppresses human papillomavirus oncoproteins, restores p53, rb, and ptpn13 proteins and inhibits benzo[a]pyrene-induced upregulation of hpv e7. | curcumin has great potential as a chemopreventive and chemotherapeutic agent; however, its effects on human papillomavirus (hpv)-associated molecular events are inadequately explored. this study examined the effects of curcumin on hpv-associated pathways involved in developing cervical cancer. we demonstrate for the first time that curcumin treatment suppresses cervical cancer cell growth in a three-dimensional raft culture system. curcumin also inhibits tumorigenic characteristics as shown by d ... | 2011 | 21061268 |
| nk1.1+ cells are important for the development of protective immunity against mhc i-deficient, hpv16-associated tumours. | loss or downregulation of mhc class i molecules on tumour cells is a common mechanism by which tumours can escape t-cell mediated immune responses. in this study, we examined the role of different immune cell lineages in the development of immunity against tumours of the same aetiology but with different mhc class i expression. in vivo depletion of cd8+ cells, but not of cd4+ or nk1.1+ cells in the immunization period resulted in complete elimination of the protective effects of immunization wit ... | 2011 | 21109988 |
| procedural and temporal compliance to cervical cancer screening guidelines in a cdc-funded program in alaska. | to estimate changes in clinical practice in a cervical cancer screening program after the american society for colposcopy and cervical pathology's issuance of 2006 consensus guidelines (2006cg) for managing abnormal pap tests. | 2011 | 21169865 |
| association of human papillomavirus-related knowledge, attitudes, and beliefs with hiv status: a national study of gay men. | anal cancer and other diseases caused by human papillomavirus (hpv) are more common among people who are hiv-positive. to understand the potential role of hiv status in hpv prevention efforts, we examined hpv-related knowledge, attitudes, and beliefs among hiv-positive and hiv-negative gay men. | 2011 | 21169868 |
| human papillomavirus vaccine: now for boys too? | 2011 | 21157346 | |
| detection of human papillomavirus in bronchoalveolar lavage samples in immunocompetent children. | human papillomavirus (hpv) has been detected in lungs of adults and has been proposed to play a role in lung carcinogenesis. however, no data are currently available on the incidence of hpv in the lower respiratory tract of children. | 2011 | 21178656 |
| regulation of immune responses to hpv infection and during hpv-directed immunotherapy. | the recent development of vaccines prophylactic against human papillomavirus (hpv) infection has the potential to reduce the incidence of cervical cancer globally by up to 70% over the next 40 years, if universal immunization is adopted. as these prophylactic vaccines do not alter the natural history of established hpv infection, immunotherapies to treat persistent hpv infection and associated precancers would be of benefit to assist with cervical cancer control. efforts to develop immuno-therap ... | 2011 | 21198666 |
| quadrivalent human papillomavirus (hpv) vaccine: a review of safety, efficacy, and pharmacoeconomics. | what is known and background: the introduction of vaccines has lead to a significant reduction in morbidity and mortality from diseases such as measles, rubella and poliomyelitis, as well as the eradication of smallpox (ertl hc, xiang z (1996) the journal of immunology, 156, 3579-3582). a recent vaccine approved by the food and drug administration (fda) is the recombinant quadrivalent human papillomavirus (hpv) vaccine (merck, gardasil®). concerns raised with this preventive measure include safe ... | 2011 | 21198715 |
| preclinical development of highly effective and safe dna vaccines directed against hpv 16 e6 and e7. | to allow vaccination irrespective of hla type, dna vaccines encoding full-length antigens are required. however, here, we demonstrate that the immunogenicity of dna vaccines encoding the full-length human papillomavirus (hpv) type 16 e7 and e6 proteins is highly reduced compared to vaccines encoding only the immunodominant epitope. furthermore, the low remaining immunogenicity is essentially lost for both e7 and e6 when a nononcogenic "gene-shuffled" variant is utilized. to address these issues, ... | 2011 | 21207427 |
| human papillomavirus in brazilian women with and without cervical lesions. | human papillomavirus (hpv) high-risk (hr) types are the causal factor for cervical cancer and premalignant dysplasia. data on frequency of hpv types provide a basis to design and evaluate hpv prevention programs. taking into account the heterogeneity of hpv types across and within populations this study aims to access the hpv frequency in brazilian women. | 2011 | 21208414 |
| long-term persistence of human papillomavirus in environments. | the possibility of its indirect transmission of human papillomavirus (hpv) via formites has been widely raised but with no biological proof. this study explored the durability of hpv16 pseudoviruses and native viruses in different environmental contamination scenarios. | 2011 | 21208649 |
| low prevalence of hpv in brazilian children with retinoblastoma. | retinoblastoma is the most frequent intra-ocular malignant tumor of the childhood, occurring in 1 of 18,000-30,000 live births. little is known about the causes of sporadic retinoblastoma and only a few authors have investigated the etiologic role of human papillomavirus (hpv), with controversial results. formalin-fixed, paraffin-embedded tissue blocks containing retinoblastoma were retrieved from the archives of the department of pathology at hospital a c camargo, são paulo, brazil. all patient ... | 2011 | 21108347 |
| human papillomavirus infection in honduran women with cervical intraepithelial neoplasia or cervical cancer. | the aims of this study were to investigate human papillomavirus (hpv) genotypes in women with cervical intraepithelial lesions and cervical cancer (cc) in honduras and to identify epidemiological cofactors that contribute to the development of cc. | 2011 | 21192177 |
| recurrent laryngeal papillomatosis: successful treatment with human papillomavirus vaccination. | the authors describe the case of a 5-year-old girl with recurrent laryngeal papillomatosis (rlp) due to human papillomavirus (hpv) type 11, who required frequent surgical treatment. complete recovery occurred after hpv vaccination (gardasil). confirmed remission of rlp has continued during the 17 months of follow-up since vaccination. the authors conclude that hpv vaccination may represent a new therapeutic option in this situation. | 2011 | 21220258 |
| population-based frequency assessment of hpv-induced lesions in patients with borderline pap tests in the emilia-romagna region: the pater study. | the pater study assessed the frequency of high-risk (hr) and low-risk (lr) human papillomavirus (hpv) in hpv-induced lesions in patients with borderline cytology. | 2011 | 21222568 |
| molecular characterization of late stomal recurrence following total laryngectomy. | the goal was to determine recurrent or second primary status for late stomal malignancies, 16 and 17 years post-total laryngectomy in two laryngeal squamous cell carcinoma (lscc) patients, based on dna methylation signatures and hpv typing. adopting a literature review based definition of late stomal recurrences as new primaries at the site of the stoma or neopharynx occurring >5 years after total laryngectomy, we employed a multi-gene candidate approach to examine promoter methylation in 24 tum ... | 2011 | 21225233 |
| identification of differential expressed transcripts in cervical cancer of mexican patients. | the aim of this study was to identify the gene expression profile in biopsies of patients with cervical intraepithelial neoplasia (cin) 1, cin 2, cin 3, and microinvasive cancer by suppression subtractive hybridization and southern blotting. after analyzing 1,800 cdna clones, we found 198 upregulated genes, 166 downregulated, and no significant change of gene expression in 86 clones (p = 0.005). these results were validated by northern blot analysis (p = 0.0001) in the identification of 28 overe ... | 2011 | 21225484 |
| a human papillomavirus 8 e7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions. | we investigated the potential of nicotiana benthamiana to express the e7 protein of human papillomavirus 8 (hpv-8), a paradigm genotype among cutaneous hpvs. the protein, modified in its putative prb-binding domain (e7(qgd)), was transiently expressed in leaves following infiltration with agrobacteria carrying either a binary vector combined with silencing suppressor constructs or replicating tobacco mosaic virus (tmv)-based vectors with different targeting signals. hpv-8 e7(qgd) yields ranged f ... | 2011 | 21234770 |
| diagnosis of anal human papillomavirus infection: polymerase chain reaction or cytology? | to investigate the relationship between human immunodeficiency virus (hiv)-positive and hiv-negative patients engaging in promiscuous behaviors and anal human papillomavirus (hpv) infection diagnosed by polymerase chain reaction (pcr) and cytology. | 2011 | 21239202 |
| molecular pathogenesis of cervical cancer. | cervical cancer is a sexually transmitted disease that results from infection with oncogenic types of human papillomavirus (hpv). oncogenic hpv dna is found in over 95% of invasive cervical cancers worldwide. cervical cancer is a leading cause of cancer deaths in developing countries because of high hpv infection rates and lack of comprehensive cervical pap smear testing of susceptible women. vaccination against hpv prevents the acquisition of cervical dysplastic lesions among eligible women who ... | 2011 | 21239888 |
| retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the e7 oncoprotein in hpv 16-positive cells. | "high risk" human papillomavirus strains are the causative agents of the vast majority of carcinomas of the uterine cervix. in these tumors, the physical integration of the hpv genome is a frequent, though not invariable occurrence, but the constitutive expression of the e6 and e7 viral genes is always observed, suggesting key roles for the e6 and e7 oncoproteins in the process of malignant transformation. the "intracellular antibody" technology using recombinant antibodies in single-chain forma ... | 2011 | 21241471 |
| single-tube multiplex pcr using type-specific e6/e7 primers and capillary electrophoresis genotypes 21 human papillomaviruses in neoplasia. | 2011 | 21241508 | |
| detection of human papillomavirus in multiple eccrine poromas in a patient with chronic graft-vs-host disease and immunosuppression. | 2011 | 21242407 | |
| development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. | we found that recircularized high-risk (type 16 and 18) and low-risk mucosal (type 6b and 11) and cutaneous (type 5 and 8) human papillomavirus (hpv) genomes replicate readily when delivered into u2os cells by electroporation. the replication efficiency is dependent on the amount of input hpv dna and can be followed for more than 3 weeks in proliferating cell culture without selection. cotransfection of recircularized hpv genomes with a linear g418 resistance marker plasmid has allowed subclonin ... | 2011 | 21248030 |
| prevalence and type distribution of human papillomavirus in healthy japanese women aged 20 to 25 years old enrolled in a clinical study. | efficacy, immunogenicity and tolerability of the human papillomavirus (hpv)-16/18 as04-adjuvanted vaccine were evaluated in japanese women aged 20-25 years, for which results have been reported previously. we analyzed the baseline data from that study and report the prevalence rates of hpv infection in young healthy japanese women. one thousand and the forty japanese women aged 20-25 years were enrolled in a phase ii, double-blind, controlled, randomized, multicenter study. at study entry, cervi ... | 2011 | 21251162 |
| cd40 is overexpressed by hpv16/18-e6 positive cervical carcinoma and correlated with clinical parameters and vascular density. | cd40 is expressed in many tumor cells, however, its role in tumor biology is yet to be demonstrated. in the present study, we investigated the role of cd40 in cervical carcinoma. in vivo, we evaluated cd40 expression in 56 cervical carcinoma tissues, 43 cervicitis and 38 normal cervix, and investigated the relationship between cd40 and hpv antigen, histopathological parameters, vascular density, and vascular endothelial growth factor (vegf) expressions. the results clearly demonstrated that cd40 ... | 2011 | 21251894 |
| estimating the impact of human papillomavirus (hpv) vaccination on hpv prevalence and cervical cancer incidence in mali. | human papillomavirus vaccines have potential to reduce cervical cancer incidence and mortality; however, cultural and economic barriers may hinder success in developing countries. we assessed impact of a single vaccine campaign in mali with use of mathematical modeling. our model shows that decreases in the prevalence of human papillomavirus infection are proportional to achieved vaccination coverage. | 2011 | 21252142 |
| correlates of receiving recommended adolescent vaccines among adolescent females in north carolina. | immunization is a successful and cost-effective method for preventing disease, yet many adolescents do not receive recommended vaccines. we assessed correlates of uptake of three vaccines (tetanus booster, meningococcal, and human papillomavirus [hpv] vaccines) recommended for adolescent females. methods. we examined cross-sectional data from 647 parents of 11-20 year-old females from north carolina who completed the carolina hpv immunization measurement and evaluation (chime) project follow-up ... | 2011 | 21263224 |
| prevalence of human papillomavirus among women with normal cervical cytology in kuwait. | this study was undertaken to determine the prevalence and type specific distribution of human papillomavirus (hpv) in women with normal cervical cytology in kuwait. the study is the first of its type in kuwait and one of few in the middle east. the age specific distribution of hpv types was determined in 3,011 thinprep samples taken from women seeking routine gynaecological care. thinprep samples were screened for hpv dna by real-time pcr. the type specific distribution of the viruses was determ ... | 2011 | 21264866 |
| expression of human papillomavirus 16 e7ggg oncoprotein on n- and c-terminus of potato virus x coat protein in bacterial and plant cells. | the e7 oncoprotein from human papillomavirus type 16 (hpv16) is an attractive candidate for anti-cancer therapeutical vaccine development. in this study, we engineered different fusions of mutagenized coding sequence of e7 oncoprotein (e7ggg) with coat protein of potato virus x (pvx cp) both on 5'- and 3'-terminus of pvx cp and evaluated the influence of the length of linker (no linker, 4, 15aa) connecting pvx cp and e7ggg on their production. at first the expression in escherichia coli was cond ... | 2011 | 21266198 |
| mutants of plant genes for developing cancer vaccines. | preventive human papillomavirus (hpv) vaccination is an expensive practice and it may be an insufficient tool to tackle cervical cancer worldwide. therapeutic intervention is seeking for safe/effective vaccines inducing the activation of cd8+ cytotoxic t lymphocytes (ctls) that is required to clear the tumor. linking a tumor-specific antigen (i.e. the e7 oncoprotein of the 'high risk' hpvs) to molecules able to increase its immune 'visibility' represents a strategy to force the immune system to ... | 2011 | 21266841 |
| phylogeny and polymorphism in the long control region, e6, and l1 of human papillomavirus types 53, 56, and 66 in central brazil. | several studies related that different human papillomavirus (hpv) types and intratype variants can present different oncogenic potential. in opposite to hpvs 16 and 18 variants, information about variants of other carcinogenic hpv types is still scarce. the aim of this study was to investigate the genetic variability of hpvs 53, 56, and 66 from central brazil isolates. | 2011 | 21270605 |
| clinicopathologic implications of the epidermal growth factor receptor, cyclooxygenase 2 expression, and human papillomavirus status in squamous cell carcinoma of the uterine cervix in the elderly. | to find information on invasive squamous cervical carcinoma in the elderly, 110 invasive squamous cervical carcinomas obtained from 2 groups of patients (aged <60 and >60 years) were analyzed for human papillomavirus (hpv) status by polymerase chain reaction study, for immunohistochemical epidermal growth factor receptor (egfr), cyclooxygenase 2 (cox-2) expression, and clinicopathologic features. | 2011 | 21270615 |
| automated high throughput dna isolation for detection of human papillomavirus in oral rinse samples. | oral hpv infection elevates risk of oropharyngeal cancer, but its natural history is unknown. natural history studies necessitate validation of an automated, high-throughput method for hpv genomic dna detection in oral rinse samples (ors). | 2011 | 21273118 |
| intradermal injection of ppd as a novel approach of immunotherapy in anogenital warts in pregnant women. | immunotherapy for treatment of recalcitrant warts was used through different modalities including intralesional injection of purified protein derivative (ppd), which is an extract of mycobacterium tuberculosis, used for testing exposure to tuberculin protein, either from a previous vaccination or from the environment. this method is used to evaluate the efficacy of a new approach of intradermal injection of ppd in the treatment of anogenital warts in pregnant women. a total of 40 pregnant women, ... | 2011 | 21276168 |
| considerations for human papillomavirus (hpv) vaccination of mid-adult women in the united states. | in the united states, human papillomavirus (hpv) vaccination is recommended for 11 or 12 year old girls, with catch-up vaccination through age 26 years. data are available for women over the age of 26 years on immunogenicity for both quadrivalent and bivalent hpv vaccines and on efficacy for the quadrivalent hpv vaccine. if hpv vaccines are licensed for use in women over 26 years of age (mid-adult women), recommendations for this age group will need to be considered. this review summarizes vacci ... | 2011 | 21277406 |
| prevalence of human papillomavirus genotypes in cytologic abnormalities from unvaccinated women living in north-western spain. | cervical cancer and its precursors low-grade squamous intraepithelial lesions (lsil) and high-grade squamous intraepithelial lesions (hsil) are associated with infection by human papillomavirus (hpv), in particular hpv 16 and 18. the distribution of the hpv genotype varies with the severity of cervical disease, age and the geographic location of the patients. we report the results of a population study carried out in a region of north-western (nw) spain aimed at determining the prevalence of sin ... | 2011 | 21284738 |
| safety of the hpv bivalent and quadrivalent vaccines during pregnancy (february). | objective: to evaluate the safety of the human papillomavirus (hpv) bivalent and quadrivalent vaccines in pregnancy. data sources: pubmed (1966-august 2010) was searched using the terms human papillomavirus, human papillomavirus vaccine, and pregnancy. references were reviewed for relevant information. study selection and data extraction: all studies including humans that were published in english with data describing hpv vaccine administration in pregnancy were evaluated. data synthesis: two co ... | 2011 | 21285408 |
| health-related quality of life in indian patients with three viral sexually transmitted infections: herpes simplex virus-2, genital human papilloma virus and hiv. | health-related quality of life (hrqol) has not been studied in indian patients with viral sexually transmitted infections (stis): herpes simplex virus-2 (hsv-2) and genital human papilloma virus (hpv) infections. furthermore, there is no reported study that compares hrqol among these two viral stis and hiv. | 2011 | 21289022 |
| biphasic vesicles for topical delivery of interferon alpha in human volunteers and treatment of patients with human papillomavirus infections. | purpose. topical biphasic vesicle delivery system encapsulating interferon alpha (ifn a) was developed as an alternative to injections used to treat human papillomavirus (hpv) infections. methods. biphasic lipid vesicles encapsulating increasing doses of ifn a (biphasic ifn a) were characterized for encapsulation efficiency, size, zeta potential and vesicle structure by centrifugation, dynamic light scattering, confocal microscopy and small-angle x-ray scattering. biphasic ifn-a delivery into hu ... | 2011 | 21291377 |
| human papillomavirus infection in women with and without cervical cancer in tbilisi, georgia. | background: no accurate estimates of cervical cancer incidence or mortality currently exist in georgia. nor are there any data on the population-based prevalence of high-risk (hr) human papillomavirus (hpv) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence. methods: we obtained cervical cell specimens from 1309 women aged 18-59 years from the general population of tbilisi, and also from 91 locally diagnosed invasive cervical cancers ... | 2011 | 21292583 |
| distribution of human papillomavirus load in clinical specimens. | the information about the range and distribution of human papillomavirus load in clinical specimens is important for the design of accurate clinical tests. the amount of human papillomavirus in cervical specimens was estimated using the digene hc2 hpv dna test(®) (qiagen). this semi-quantitative assay is based on linear signal amplification with an analytical limit-of-detection of approximately 2500 virus copies per assay and 3-4 log dynamic range. the dynamic range of the assay was extended by ... | 2011 | 21295613 |
| frequency of human papillomavirus infection, coinfection, and association with different risk factors in colombia. | the aims of this study were to provide new insights into infection patterns of six high-risk human papillomaviruses (hr-hpv-16, -18, -31, -33, -45, and -58) and two low-risk hpv types (lr-hpv-6 and -11), their association with risk factors and coinfection. | 2011 | 21296271 |
| bd-proexc as adjunct molecular marker for improved detection of cin2+ after hpv primary screening. | we investigated the efficacy of 8 cervical cancer screening strategies relative to cytology with emphasis on immunocytochemical detection of high-risk human papillomavirus (hrhpv)-induced cell transformation (bd-proexc) as a tool of triage following primary cytology or hrhpv testing. 3,126 women were tested with bd-surepath liquid-based cytology, hrhpv pcr genotyping and bd-proexc immunostaining, and colposcopy verification to calculate sensitivity and positive predictive value (ppv) in detectin ... | 2011 | 21297040 |
| text message reminders to promote human papillomavirus vaccination. | to implement and evaluate text message reminders for the second (hpv2) and third (hpv3) vaccine doses. | 2011 | 21300094 |
| the hpv vaccine: are dosing recommendations being followed? | the aims of this study were to determine the percentage of females who after initiating the human papillomavirus (hpv) vaccine series, both completed it and completed it on-time, as well as to examine factors associated with series completion and on-time completion. using data from the north carolina immunization registry, of 138,823 females analyzed, 55% completed the series, and 28% completed it on-time. over 83% of those who initiated the vaccine series in 2006 completed it by the final study ... | 2011 | 21300098 |
| acceptability of human papillomavirus vaccine among the urban, affluent and educated parents of young girls residing in kolkata, eastern india. | aim: the human papillomavirus (hpv) vaccine is recommended for adolescent girls and young women; however, the social structure in india will not permit vaccination of this age-group without parental approval. our study aimed to explore the attitude of affluent, urban indian parents towards the hpv vaccine. methods: well-to-do married couples with at least one daughter between 9-26 years of age were interviewed using a questionnaire in two parts. the first part was to assess their attitude to v ... | 2011 | 21314807 |
| biomarker expression in cervical intraepithelial neoplasia: potential progression predictive factors for low-grade lesions. | the aim of this study was to reveal whether 3 biomarkers (p16ink4a, proex c, and human papilloma virus dna) are useful in the diagnosis of cervical intraepithelial neoplasia and whether they could predict disease progression of cervical intraepithelial neoplasia-1. we analyzed 252 cervical specimens: nondysplastic mucosa (n = 9), cervical intraepithelial neoplasia (n = 229), and squamous cell carcinoma (n = 14). immunostaining for p16ink4a and proex c, and the hybridcapture ii assay for human pa ... | 2011 | 21315414 |
| survival and human papillomavirus in oropharynx cancer in tax 324: a subset analysis from an international phase iii trial. | the association between human papillomavirus (hpv) and overall survival (os) in oropharynx cancer (opc) was retrospectively examined in tax 324, a phase iii trial of sequential therapy for locally advanced head and neck cancer. | 2011 | 21317223 |
| the role of human papillomavirus infection in breast cancer. | breast cancer is the leading female cancer and the third most common cause of cancer deaths worldwide. many studies have suggested a possible link between breast cancer pathogenesis and viral infection, particularly mouse mammary tumour virus, simian virus 40, epstein-barr virus, and human papillomavirus (hpv). a significant number of recent studies have reported that approximately 29% of human breast cancer tissues were positive for high-risk hpv subtypes, especially hpv subtypes 16, 18, or 33. ... | 2011 | 21318737 |
| identification of key amino acid residues that determine the ability of high risk hpv16-e7 to dysregulate major histocompatibility complex class i expression. | high risk human papillomavirus (hpv) types are the major causative agents of cervical cancer. reduced expression of major histocompatibility complex class i (mhc i) on hpv-infected cells might be responsible for insufficient t cell response and contribute to hpv-associated malignancy. the viral gene product required for subversion of mhc i synthesis is the e7 oncoprotein. although it has been suggested that high and low risk hpvs diverge in their ability to dysregulate mhc i expression, it is no ... | 2011 | 21321113 |
| comparison of hpv genotyping assays and hybrid capture 2 for detection of high-risk hpv in cervical specimens. | high-risk types of human papillomavirus (hr-hpv) are among the primary causes of cervical cancers. hybrid capture 2 (hc-ii) (digene, gaithersburg, md), which detects 13 hr-hpvs as a group, is the only hpv assay approved to date by the united states food and drug administration. in korea, several hpv genotyping assays are commercially available, including hpv rfmp (genematrix co., seoul), hpvdnachip (biomedlab co., seoul), and myhpv chip (mygene co., seoul). we compared the results of these assay ... | 2011 | 21325255 |
| rapid genotyping of human papillomavirus by post-pcr array-based hybridization techniques. | kinetic hybridization measurements on a microarray are expected to become a valuable tool for genotyping applications. a method has been developed that enables kinetic hybridization measurements of pcr products on a low-density microarray. this is accomplished by pumping a solution containing pcr products up and down through a porous microarray substrate. after every pumping cycle, the fluorescently labeled pcr products hybridized to capture probes immobilized on the solid surface of the porous ... | 2011 | 21325552 |
| prevalence and clinical features of human papillomavirus in head and neck squamous cell carcinoma in okinawa, southern japan. | previous studies from okinawa, a subtropical island in southern japan, demonstrated a higher prevalence of human papillomavirus (hpv) in oral carcinoma and a higher incidence of oral and pharyngeal carcinoma than those for mainland japan. the present study aims to investigate epidemiologic and clinical features of hpv in head and neck squamous cell carcinoma (hnscc) in okinawa. a total of 150 dna samples from 150 okinawan patients with head and neck squamous cell carcinoma (hnscc) were screened ... | 2011 | 21328000 |
| casp8 promoter polymorphism is associated with high-risk hpv types and abnormal cytology but not with cervical cancer. | only a small fraction of women infected with human papillomavirus (hpv) progress to cervical cancer pointing to additional risk factors including host genetics that might play a role in development of cervical cancer. caspase-8 (encoded by casp8 gene) is crucial in generating cell death signals to eliminate potentially malignant cells. genetic variation in casp8 might influence the susceptibility to cancer. casp8 -652 6n ins/del polymorphism has been previously reported to influence the progress ... | 2011 | 21328377 |
| hpv types and variants among cervical cancer tumors in three regions of tunisia. | cervical cancer is the second most common cancer among tunisian women, and the incidence rates vary by region. three tunisian registries report age-standardized rates of 6.3/10(5) in the central region, 5.4/10(5) in the north, and 2.7/10(5) in the south. high-risk human papillomavirus (hpv) types and their variants differ in carcinogenic potential and geographic distribution. the hpv type and variant distribution could be a factor in the differing rates between regions of tunisia. tumor tissue w ... | 2011 | 21328380 |
| oral lichen planus: malignant transformation and human papilloma virus: a review of potential clinical implications. | oral lichen planus (olp) occurs in from 2% to 3% of the population and may have a risk of malignant transformation into squamous cell carcinoma (scc). this risk is not necessarily associated with exposure to tobacco and alcohol. an increased awareness of a possible role of human papilloma virus (hpv) and scc led us to review a possible association between this virus infection and malignant transformation of olp. the possible linkage between hpv and the risk of transformation of olp to malignancy ... | 2011 | 21330164 |
| survivin and telomerase expression in the uterine cervix of women with human papillomavirus-induced lesions. | infection by human papillomavirus is the most important risk factor in the pathogenesis of uterine cervical cancer. the aims of this study were to evaluate the expression of survivin protein and telomerase enzyme in samples of uterine cervix from women with human papillomavirus-induced lesions and to determine the relationship between survivin and telomerase expression and the different grades of cervical squamous intraepithelial neoplasia and invasive cervical carcinoma. | 2011 | 21330827 |
| cost-consequences evaluation between bivalent and quadrivalent hpv vaccines in italy: the potential impact of different cross-protection profiles. | two human papillomavirus (hpv) vaccines are currently available: a bivalent hpv-16/18 and a quadrivalent hpv-6/11/16/18 vaccine. the vaccines may have different sustained- and cross-protection levels against non-vaccine oncogenic hpv-types. this study investigated the potential difference in clinical and economic impacts provided by two hpv vaccines in italy. | 2011 | 21334734 |
| women's sexual behavior. population-based study among 65,000 women from four nordic countries before introduction of human papillomavirus vaccination. | sexual behavior is of public health interest because of the association with reproductive health and sexually transmitted infections such as human papillomavirus, which is the causal factor of cervical cancer. the aim of the study was to describe patterns in women's sexual behavior in four nordic countries. | 2011 | 21306319 |
| lack of hpv 16 and 18 detection in serum of colposcopy clinic patients. | persistent infection with high-risk human papillomavirus (hpv) types is necessary for the development of high-grade cervical dysplasia and cervical carcinoma. the presence of hpv dna in the blood of cervical cancer patients has been reported; however, whether hpv dna is detectable in the blood of patients with pre-invasive cervical disease is unclear. | 2011 | 21306941 |
| human papillomavirus-related squamous cell carcinoma of the oropharynx: a comparative study in whites and african americans. | to evaluate the frequency of human papillomavirus-related oropharyngeal squamous cell carcinoma in african americans and whites and to examine patient outcomes in these 2 groups. | 2011 | 21339403 |
| completion of the human papillomavirus vaccine series in females attending an urban immunization clinic. | this project characterized the extent to which women and girls who initiated human papillomavirus vaccination between 2007 and 2009 at the baltimore city health department completed the full vaccine series, and reasons for failure to follow-up. more than 85% of girls and women had an incomplete series, and it was not possible to reach 80% of these girls and women using the phone number provided. those who were contacted reported not knowing they needed further doses, having forgotten, being too ... | 2011 | 21343841 |
| high-risk human papillomavirus testing in women with asc-us cytology: results from the athena hpv study. | this study evaluated the clinical performance of the cobas 4800 hpv test (roche molecular systems, pleasanton, ca) for high-risk human papillomavirus (hr-hpv) testing with individual hpv-16/hpv-18 genotyping in women 21 years or older with atypical squamous cells of undetermined significance (asc-us). women (n = 47,208) were recruited in the united states during routine screening, and liquid-based cytology and hpv testing were performed. the asc-us prevalence was 4.1% (1,923/47,208), and 1,578 w ... | 2011 | 21350104 |
| potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts. | the p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (hpv). the hpv e6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. in our study, we attempted to improve the clinical outcomes of this combined therapy by modifying the p53-targeted adenovirus to become radiation-responsive. the antitumor adenovirus was constructed by inserting a radiat ... | 2011 | 21351100 |
| self-collected human papillomavirus testing acceptability: comparison of two self-sampling modalities. | human papillomavirus (hpv) testing can be used as a primary test for cervical cancer screening. hpv self-sampling has the potential to replace physician/nurse sampling. our objective was to compare the acceptability of two self-sampling methods among 205 women undergoing an excisional procedure for cervical intraepithelial neoplasia (cin) at the european institute of oncology (ieo). | 2011 | 21351869 |
| human papillomavirus detection in moroccan patients with nasopharyngeal carcinoma. | 2011 | 21352537 | |
| immortalisation of normal human urothelial cells compromises differentiation capacity. | the development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade. although tumour grade is an independent prognostic marker for urothelial carcinoma (uc), the molecular events underpinning the loss of urothelial differentiation are poorly understood. | 2011 | 21353380 |
| clinical experience with the cervista hpv hr assay: correlation of cytology and hpv status from 56,501 specimens. | testing for high-risk (hr) human papillomavirus (hpv) is a key component of current recommendations for cervical cancer screening. herein is described our clinical experience using cervista hpv hr, a testing platform recently approved by the us food and drug administration for clinical use. using data from a high-volume commercial laboratory, a retrospective analysis of cytologic and cervista hpv hr test results from 56,501 samples was performed, and an indirect comparison was made with previous ... | 2011 | 21354050 |
| for cancers caused by hpv, two vaccines were just the beginning. | 2011 | 21357595 | |
| epidermal growth factor genetic variation associated with advanced cervical cancer in younger women. | objectives: epidermal growth factor (egf) stimulates cell proliferation by binding to its receptor (epidermal growth factor receptor), and the overexpression of this receptor is associated with poorer prognosis. the egf gene presents a polymorphism at position 61 (a/g), associated with higher egf production. we examined the association between this polymorphism and cervical cancer through a case-control study. methods: this study used the pcr-restriction fragment length polymorphism method on a ... | 2011 | 21358296 |
| prevalence of cervical human papillomavirus infection among married women in hanoi, vietnam, 2010. | human papillomavirus (hpv) is a necessary cause of cervical cancer. this study examined the prevalence of cervical hpv infection and the distribution of hpv specific types among married women in hanoi to provide updated data for planning cancer preventive activities. sample of 750 married women aged 15 to 69 years were interviewed and had gynecological examination. hpv infection status and hpv genotyping tests were done for all participants. results: indicated that the prevalence of cervical hpv ... | 2011 | 21362673 |
| haart and progression to high-grade anal intraepithelial neoplasia in men who have sex with men and are infected with hiv. | human immunodeficiency virus (hiv)-seropositive men who have sex with men (msm) are at risk for anal intraepithelial neoplasia (ain) and cancer. the goal of this study was to identify risk factors associated with high-grade ain (ain-2,3) in hiv-positive msm, including the receipt of highly active antiretroviral therapy (haart). | 2011 | 21364075 |
| human papillomavirus vaccination in males: the state of the science. | human papillomavirus (hpv) is an extremely prevalent sexually transmitted infection that is typically acquired soon after onset of sexual activity. the burden of hpv-related malignant and nonmalignant disease is high in men and women. high-risk or oncogenic types of hpv cause cervical, vaginal, and vulvar cancer in women. these types have also been shown to cause penile cancer in men and a substantial proportion of oropharyngeal and anal malignancy in men and women. low-risk types of hpv cause a ... | 2011 | 21365381 |
| performance of p16ink4a immunocytochemistry as a marker of anal squamous intraepithelial lesions. | protein p16(ink4a) immunocytochemistry (iccp16) has the potential to reveal lesions at risk of progression to anal cancer. this study examined measures of diagnostic validity of iccp16 in hiv-positive patients treated at the tropical medicine foundation of amazonas in the coloproctology outpatient clinic. | 2011 | 21365778 |
| treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the erk1/2 signaling pathway. | numerous epidemiological studies have implicated cigarette smoking as a cofactor in the progression to cervical cancer. tobacco-associated hydrocarbons have been found in cervical mucus, suggesting a possible interaction with human papillomavirus (hpv)-infected cells. the polycyclic aromatic hydrocarbon benzo[a]pyrene (bap) is a major component of cigarette smoke condensate that has received significant attention due to its ability to induce carcinogenesis. we have previously demonstrated by con ... | 2011 | 21367897 |
| new indication approved for hpv vaccine. | 2011 | 21370548 | |
| multiple human papillomavirus infections: the exception or the rule? | 2011 | 21402540 | |
| human papillomavirus infection with multiple types: pattern of coinfection and risk of cervical disease. | we investigated coinfection patterns for 25 human papillomavirus (hpv) types and assessed the risk conferred by multiple hpv types toward cervical disease. | 2011 | 21402543 |
| human papillomavirus in head and neck cancers: biology, prognosis, hope of treatment, and vaccines. | human papillomaviruses (hpvs), especially type 16, are implicated in the development of a subset of head and neck squamous cell cancers (hnsccs). this subset of oropharyngeal cancers possesses distinct clinical and laboratory features and outcome, and is particularly common in individuals who lack the traditional risk factors of tobacco and alcohol abuse. moreover, the annual incidence of hpv-related hnsccs has increased in the usa and europe in the last few years. as hpv-associated hnsccs share ... | 2011 | 21403517 |
| alternative her/pten/akt pathway activation in hpv positive and negative penile carcinomas. | the pathogenesis of penile squamous cell carcinoma (pscc) is not well understood, though risk factors include human papillomavirus (hpv). disruption of her/pten/akt pathway is present in many cancers; however there is little information on its function in pscc. we investigated her family receptors and phosphatase and tension homolog (pten) in hpv-positive and negative pscc and its impact on akt activation using immunohistochemistry and fluorescent in situ hybridisation (fish). | 2011 | 21407808 |
| mechanism of human papillomavirus binding to human spermatozoa and fertilizing ability of infected spermatozoa. | human papillomaviruses (hpvs) are agents of the most common sexually transmitted diseases in females and males. precise data about the presence, mechanism of infection and clinical significance of hpv in the male reproductive tract and especially in sperm are not available. here we show that hpv can infect human sperm, it localizes at the equatorial region of sperm head through interaction between the hpv capsid protein l1 and syndecan-1. sperm transfected with hpv e6/e7 genes and sperm exposed ... | 2011 | 21408100 |
| human papillomavirus's physical state and cyclin a1 promoter methylation in cervical cancer. | cervical cancer is the second biggest cause of death among human female cancers. human papillomavirus (hpv) is the main factor in this cancer, especially hpv types 16 and 18, which constitute the high-risk group. there are 2 physical states of hpv in host cells: integrated and episomal forms. our previous study explored the very high degree of cyclin a1 (ccna1) promoter methylation in invasive cervical cancer in which all cases were infected by hpv. | 2011 | 21412159 |
| risk factors for hpv infection among american indian and white women in the northern plains. | american indian (ai) women living in the northern plains have high incidence and mortality rates for cervical cancer. we assessed risk factors for human papillomavirus (hpv) infection among ai and white women. | 2011 | 21414655 |
| a novel real-time genotyping assay for detection of the e6-350g hpv 16 variant. | it has been suggested that some e6 human papillomavirus (hpv) type 16 variants could be involved in viral persistence and progression of hpv infection. a novel one-step allelic discrimination real-time pcr was evaluated for e6-350g variant detection in 102 endocervical hpv 16 positive samples. this assay was also used to assess the distribution of this variant in spanish women with cervical cancer related to hpv 16. the detection limit for the allelic discrimination assay was 50 copies per react ... | 2011 | 21419166 |
| ki-67 and proexc are useful immunohistochemical markers in esophageal squamous intraepithelial neoplasia. | esophageal squamous intraepithelial neoplasia has been widely recognized as a precursor lesion for esophageal squamous cell carcinoma. early detection offers the best prognosis for esophageal squamous cell carcinoma. the differentiation of squamous dysplasia from reactive change and the classification of squamous dysplasia into high-grade or low-grade are sometimes subjective and challenging. in this study, we sought to evaluate multiple biomarkers and to develop clinically useful adjunct tools ... | 2011 | 21420715 |
| the impact of epithelial biomarkers, local immune response and human papillomavirus genotype in the regression of cervical intraepithelial neoplasia grades 2-3. | 15-30% of cases of cervical intraepithelial neoplasia grades 2-3 (cin2-3) detected in punch biopsies regress spontaneously (ie, show cin1 or less in the follow-up cone). epithelial retinoblastoma protein (prb), tumour suppressor protein (p53), hpv genotype and immunoreactive cells have been reported to be helpful in predicting regression but their interaction in regression prediction is unknown. | 2011 | 21421698 |
| human papillomavirus-induced lesions on tattoos may show features of seborrheic keratosis. | 2011 | 21422356 | |
| [demyelinating disease and vaccination of the human papillomavirus]. | primary prevention by prophylactic vaccination against the major cause of cervical cancer, the carcinogenic human papillomavirus (hpv) types 16 and 18, is now available worldwide. postlicensure adverse neurological effects have been described. the studies realized after the license are descriptive and limited by the difficulty to obtain the information, despite most of the statistical indexes show that the adverse effects by the vaccine of the hpv are not upper compared with other vaccines, the ... | 2011 | 21425100 |
| in vivo longitudinal imaging of experimental human papillomavirus infection in mice with a multicolor fluorescence mini-endoscopy system. | human papillomavirus (hpv) infection is the most common sexually transmitted infection. vaccines for hpv infection can reduce the risk of developing cervical cancer. to further improve such vaccines and to explore other methods of preventing or treating viral infection, longitudinal studies in experimental animals are desirable. here, we describe a newly developed multicolor endoscopic fluorescence imaging system to visualize early hpv infection with fluorescent protein-encoded pseudoviruses (ps ... | 2011 | 21430072 |
| comparison of clinical and analytical performance of the abbott realtime high risk hpv test to the performance of hybrid capture 2 in population-based cervical cancer screening. | the clinical performance of the abbott realtime high risk hpv (human papillomavirus) test (realtime) and that of the hybrid capture 2 hpv dna test (hc2) were prospectively compared in the population-based cervical cancer screening setting. in women >30 years old (n = 3,129), the clinical sensitivity of realtime for detection of cervical intraepithelial neoplasia of grade 2 (cin2) or worse (38 cases) and its clinical specificity for lesions of less than cin2 (3,091 controls) were 100% and 93.3%, ... | 2011 | 21430098 |
| molecular methods for a correct diagnosis of multiple hpv infections and clinical implications for vaccine. | the human papillomavirus (hpv) family is characterized by minimal genotypic differences corresponding to different virus types. the aim of this study was to detect the hpv coinfections and the inner genotype in a series of 336 cervical-vaginal samples. | 2011 | 21430458 |
| high-risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer. | background: the purpose of this study was to determine the role of high-risk human papillomavirus (hpv) in lymph node metastasis and the depth of invasion in oropharyngeal cancer. methods: the study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. high-risk hpv in situ hybridization was performed to detect hpv infection. results: the positive rate of high-risk hpv in situ hybridization was 15.4% (24 of 156). there was a significant difference in the fraction of positive ... | 2011 | 21438064 |
| nuclear translocation of +¦-catenin and decreased expression of epithelial cadherin in human papillomavirus-positive tonsillar cancer: an early event in human papillomavirus-related tumour progression? | high-risk human papillomaviruses (hpvs) constitute an important risk factor for tonsillar cancer. this study describes changes in cell adhesion molecules during metastasis of hpv-related and hpv-unrelated tonsillar carcinomas. | 2011 | 21438909 |
| a cyano analogue of boswellic acid induces crosstalk between p53/puma/bax and telomerase that stages the human papillomavirus type 18 positive hela cells to apoptotic death. | the p53 tumor suppressor pathway is disrupted by human papillomavirus (hpv) in over 90% of cervical cancers. hpv e6 protein promotes the degradation of p53 thereby inhibiting its stabilization and activation. this study demonstrates that treatment with a novel cyano derivative of 11-keto-ß-boswellic acid, i.e. butyl 2-cyano-3, 11-dioxours-1,12-dien-24-oate (bcdd) reduced the viral e6 mrna expression and lead to the accumulation of transcriptionally active p53 in the nucleus of hpv18 hela cells f ... | 2011 | 21440536 |