Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| appendix to dialysis centre guidelines: recommendations for the relationship between outpatient haemodialysis centres and reference hospitals. opinions from the outpatient dialysis group. | introduction: the different clinical guidelines backed by the spanish society of nephrology (sen) attempt to homogenise the monitoring of renal patients. however, this effort to homogenise treatment has been obstructed in the case of renal replacement therapy patients on haemodialysis due to, among other reasons, the existence of several different dialysis providers, with private centres located in many cities, each with their own reference hospitals and different criteria for treatment based on ... | 2011 | 22130281 |
| surveillance snapshot: service members with hepatitis b, hepatitis c, and hiv-1, active component, u.s. armed forces. | risk factors and routes of transmission of hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency virus (hiv) are similar; therefore, individuals infected with one of these viruses may be coinfected or at high risk of acquiring another infection. among active component service members diagnosed with hbv infections (n=2,204) between 2000 and 2010, 86 (3.9%) were also diagnosed with hcv and 49 (2.2%) with hiv-1. among service members diagnosed with hcv infections (n=3,185) be ... | 2011 | 21879788 |
| emergence of hbv resistance to lamivudine (3tc) in hiv/hbv co-infected patients in the gambia, west africa. | abstract: background: lamivudine (3tc) is a potent inhibitor of both hepatitis b virus (hbv) and human immunodeficiency virus (hiv) replication and is part of first-line highly active antiretroviral therapy (haart) in the gambia. unfortunately, the effectiveness of 3tc against hbv is limited by the emergence of resistant strains. aim: the aim of this retrospective study was to characterise 3tc-resistant mutations in hbv from co-infected patients receiving haart, by generating hbv polymerase se ... | 2011 | 22195774 |
| ribosome inactivating proteins from plants inhibiting viruses. | many plants contain ribosome inactivating proteins (rips) with n-glycosidase activity, which depurinate large ribosomal rna and arrest protein synthesis. rips so far tested inhibit replication of mrna as well as dna viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (hiv), hepatitis b virus (hbv) and herpes simplex virus (hsv). most of the research work related to rips has been focused on antiviral act ... | 2011 | 22160935 |
| genome-wide association study of hepatocellular carcinoma in southern chinese patients with chronic hepatitis b virus infection. | one of the most relevant risk factors for hepatocellular carcinoma (hcc) development is chronic hepatitis b virus (hbv) infection, but only a fraction of chronic hbv carriers develop hcc, indicating that complex interactions among viral, environmental and genetic factors lead to hcc in hbv-infected patients. so far, host genetic factors have incompletely been characterized. therefore, we performed a genome-wide association (gwa) study in a southern chinese cohort consisting of 95 hbv-infected hc ... | 2011 | 22174901 |
| increased hcmv seroprevalence in patients with hepatocellular carcinoma. | abstract: | 2011 | 22032643 |
| antiviral drugs for viruses other than human immunodeficiency virus. | most viral diseases, with the exception of those caused by human immunodeficiency virus, are self-limited illnesses that do not require specific antiviral therapy. the currently available antiviral drugs target 3 main groups of viruses: herpes, hepatitis, and influenza viruses. with the exception of the antisense molecule fomivirsen, all antiherpes drugs inhibit viral replication by serving as competitive substrates for viral dna polymerase. drugs for the treatment of influenza inhibit the ion c ... | 2011 | 21964179 |
| enchanced levels of apolipoprotein m during hbv infection feedback suppresses hbv replication. | chronic liver diseases can interfere with hepatic metabolism of lipoproteins, apolipoproteins. hepatitis b virus (hbv) is a major etiological agent causing acute and chronic liver diseases. apolipoprotein m (apom) is a high-density lipoprotein (hdl) apolipoprotein and exclusively expressed in the liver parenchyma cells and in the tubular cells of the kidney. this study was to determine the correlation between hbv infection and apom expression. | 2011 | 21875437 |
| expression of pattern recognition receptors in liver biopsy specimens of children chronically infected with hbv and hcv. | pattern recognition receptors (prrs) constitute a pivotal arm of innate immunity. their distribution is widespread and not limited to cells of the immune system. following our previous findings concerning the expression of toll-like receptors (tlrs) 2, 3 and 4 in chronic viral hepatitis c of children, we wished to search for other prrs, including other tlrs, nod-like receptors (nlrs) and rig-1-like helicase receptors (rlr) in infected hepatocytes. liver biopsy fragments from ten children with ch ... | 2011 | 22038219 |
| hepatitis b virus and hepatocellular carcinoma at the mirna level. | to study hepatitis b virus (hbv) infection and its association with hepatocellular carcinoma (hcc) at the mirna level. | 2011 | 21876625 |
| toll-like receptors signaling contributes to immunopathogenesis of hbv infection. | innate and adaptive immune systems have important role in the pathogenesis of acute and chronic infection with hepatitis b virus (hbv). these immune responses are mediated through complex interactions between the innate immune response and adaptive immune response. toll-like receptors (tlrs) are a family of innate immune-recognition receptors that recognize the molecular patterns associated with microbial pathogens. so far, tlr1 to 13 were found in human or mice and investigated to detect the ta ... | 2011 | 22190911 |
| inhibition of hepatitis b virus replication by ciap2 involves accelerating the ubiquitin-proteasome-mediated destruction of polymerase. | cellular inhibitor of apoptosis protein 2 (ciap2) is a potent suppressor of apoptotic cell death. we have shown previously that ciap2 is involved in the tumor necrosis factor alpha (tnf-α)-induced anti-hepatitis b virus (hbv) response; however, the mechanism for this antiviral effect remains unclear. in the present study, we demonstrate that ciap2 can significantly reduce the levels of hbv dna replication intermediates but not the total viral rna or core protein levels. domain-mapping analysis r ... | 2011 | 21865390 |
| first-time donors responding to a national disaster may be an untapped resource for the blood centre. | background on 12 may 2008, a severe earthquake struck sichuan in china. many people donated blood for the first time, leading us to question whether these donors might become repeat donors in the future. the return pattern of post-earthquake first-time donors (peftd) was compared with that of first-time donors (ftd) in a comparable period. methods demographic characteristics, transfusion-transmissible infection rates and 1-year return rates were compared between 5147 peftd (5/13-5/19, 2008) an ... | 2011 | 21988212 |
| prediction of hepatocellular carcinoma development by plasma adamts13 in chronic hepatitis b and c. | chronic liver injury evokes a wound healing response, promoting fibrosis and finally hepatocellular carcinoma (hcc), in which hepatic stellate cells play an important role. although a blood marker of hepatic stellate cells is not known, those cells importantly contribute to the regulation of plasma a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (adamts13) activity, a defect of which causes thrombotic thrombocytopenic purpura. | 2011 | 21876190 |
| the presence of helicobacter pylori in the liver depends on the th1, th17 and treg cytokine profile of the patient. | the hypothesis that helicobactermight be a risk factor for human liver diseases has arisen after the detection of helicobacter dna in hepatic tissue of patients with hepatobiliary diseases. nevertheless, no explanation that justifies the presence of the bacterium in the human liver has been proposed. we evaluated the presence of helicobacterin the liver of patients with hepatic diseases of different aetiologies. we prospectively evaluated 147 patients (106 with primary hepatic diseases and 41 wi ... | 2011 | 22012231 |
| identification of hbsag-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor. | hepatitis b immunoglobulin (hbig) is important in the management of hepatitis b virus (hbv) infection. aiming to develop recombinant monoclonal antibodies as an alternative to hbig, we report the successful identification of hbv surface antigen (hbsag)-specific antibodies from a full-length human antibody library displayed on mammalian cell surface. using total rna of peripheral blood mononuclear cells of a natively immunized donor as template, the antibody repertoire was amplified. combining fo ... | 2011 | 22179672 |
| presteady state kinetic investigation of the incorporation of anti-hepatitis b nucleotide analogues catalyzed by noncanonical human dna polymerases. | antiviral nucleoside analogues have been developed to inhibit the enzymatic activities of the hepatitis b virus (hbv) polymerase, thereby preventing the replication and production of hbv. however, the usage of these analogues can be limited by drug toxicity because the 5'-triphosphates of these nucleoside analogues (nucleotide analogues) are potential substrates for human dna polymerases to incorporate into host dna. although they are poor substrates for human replicative dna polymerases, it rem ... | 2011 | 22132702 |
| Inhibitory effects of silver nanoparticles on H1N1 influenza A virus in vitro. | Silver nanoparticles have demonstrated efficient inhibitory activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). However, the effects of silver nanoparticles against H1N1 influenza A virus remain unexplored. In this study, the interaction of silver nanoparticles with H1N1 influenza A virus was investigated. Silver nanoparticles with mean particle diameters of 10nm were prepared for the hemagglutination inhibition test, the embryo inoculation assay, and the Mosmann-b ... | 2011 | 21945220 |
| [Regulation of hepatitis B virus X protein on the expression of HSP90a gene in human hepatocarcinoma cells.] | Not Abstract. | 2011 | 22152324 |
| Reactivation of hepatitis B virus after glioblastoma treatment with temozolomide--case report. | A 61-year-old man with glioblastoma and positive for hepatitis B surface antigen (HBsAg) developed acute hepatitis due to hepatitis B virus (HBV) reactivation after concomitant postoperative treatment with temozolomide (75 mg/m(2)/day) and radiation therapy (60 Gy in 30 fractions). Corticosteroids were not used during chemo-radiation therapy, and grade 4 lymphocytopenia was observed. The levels of liver function tests (LFTs), including levels of aspartate aminotransferase and alanine aminotransf ... | 2011 | 22027252 |
| Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case-control study. | Human leukocyte antigen DP (HLA-DP) locus has been reported to be associated with hepatitis B virus (HBV) infection in populations of Japan and Thailand. We aimed to examine whether the association can be replicated in Han Chinese populations. | 2011 | 21904616 |
| relationship between hbv cccdna expression in the human ovary and vertical transmission of hbv. | summarythis study aimed to investigate the relationship between hepatitis b virus (hbv) covalently closed circular dna (cccdna) in the ovary and vertical transmission of hbv. hbv dna and hbv cccdna were assayed in the ovaries of 33 pregnant women who were positive for hbv dna. the hbvm (hbv markers, including hbsag, hbsab, hbeag, hbeab, hbcab) level and the hbv dna content in peripheral blood of infants were measured. the overall positive rate of hbv dna and hbv cccdna in samples was 51·52% (17/ ... | 2011 | 22000033 |
| hepatitis b virus induces a novel inflammation network involving three inflammatory factors, il-29, il-8, and cyclooxygenase-2. | chronic inflammation induced by hepatitis b virus (hbv) is a major causative factor associated with the development of cirrhosis and hepatocellular carcinoma. in this study, we investigated the roles of three inflammatory factors, il-8, il-29 (or ifn-λ1), and cyclooxygenase-2 (cox-2), in hbv infection. we showed that the expression of il-29, il-8, and cox-2 genes was enhanced in hbv-infected patients or in hbv-expressing cells. in hbv-transfected human lymphocytes and hepatocytes, il-29 activate ... | 2011 | 21957142 |
| Serological Pattern of Hepatitis B, C, and HIV Infections Among Immigrants in Sicily: Epidemiological Aspects and Implication on Public Health. | The objective of this study was to describe the prevalence of Hepatitis B virus (HBV), Hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections in a cohort of immigrants living in Palermo, Sicily. The study was carried out in the period May 2006-June 2010 and recruited a total of 393 patients (59.8% males-median age of 32.6 years). All patients were tested for serological markers of HBV, HCV, and HIV infection. One-hundred thirty-eight (35.1%) individuals did not show any HBV/H ... | 2011 | 21922163 |
| prevalence and factors associated with hsv-2 and hepatitis b infections among truck drivers crossing the southern brazilian border. | the authors estimate the prevalence of hiv, syphilis, hepatitis b virus (hbv) and herpes simplex virus type-2 (hsv-2) infection and correlates of hbv and hsv-2 infection among truck drivers crossing the southern brazilian border at foz do iguaçu. | 2011 | 21968460 |
| Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis. | Hepatitis B virus (HBV) transcription and replication are essentially restricted to hepatocytes because liver-enriched transcription factors govern viral RNA synthesis. The level of transcription from the HBV promoters depends on both the transcription factors binding to these regulatory sequence elements and their ability to recruit coactivators capable of mediating assembly of the transcription preinitiation complex containing RNA polymerase II. Nuclear receptors are a primary determinant of H ... | 2011 | 21880746 |
| Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice. | Current treatments for HBV chronic carriers using interferon alpha or nucleoside analogues are not effective in all patients and may induce the emergence of HBV resistant strains. Bay 41-4109, a member of the heteroaryldihydropyrimidine family, inhibits HBV replication by destabilizing capsid assembly. The aim of this study was to determine the antiviral effect of Bay 41-4109 in a mouse model with humanized liver and the spread of active HBV. Antiviral assays of Bay 41-4109 on HepG2.2.15 cells c ... | 2011 | 22162746 |
| CMV drives clonal expansion of NKG2C(+) NK cells expressing self-specific KIRs in chronic hepatitis patients. | Natural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV) manifested by increased expression of the HLA-E binding activating receptor NKG2C. We here show that HCMV seropositivity was associated with a profound expansion of NKG2C(+) CD56(dim) NK cells in patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Multi-color flow cytometry revealed that the expanded NKG2C(+) CD56(dim) NK cells displayed a highly differentiated phenotype, expre ... | 2011 | 22105371 |
| a hypoallergenic cat vaccine based on fel d 1-derived peptides fused to hepatitis b pres. | allergen-specific immunotherapy is clinically effective for the treatment of cat allergy but shows a high rate of side effects. | 2011 | 21411130 |
| herpes simplex virus infections among rural residents in eastern china. | herpes simplex virus (hsv) has two types: hsv-1 and hsv-2. both infect epithelial cells and establish latent infections in neurons causing an infection that persists for life. information on age- and gender-specific seroprevalence of hsv-1 and hsv-2 is valuable for understanding hsv transmission dynamics and designing population-based prevention and intervention programs for hsv. however, such information is not available for china. | 2011 | 21414231 |
| [in vitro study on the anti-hsv-1 and hbv activities of extracts from the fruit of eucalyptus maidenii]. | to investigate the antiviral activities of three kinds of extracts from the fruit of eucalyptus maidenii against herpes simplex virus typel and hepatitis b virus. | 2011 | 21823484 |
| ethanol extract from ampelopsis sinica root exerts anti-hepatitis b virus activity via inhibition of p53 pathway in vitro. | ampelopsis sinica root is widely used in chinese folk medicine for treating liver disorders caused by the hepatitis b virus (hbv). the present study was performed in order to investigate the anti-hbv activity and mechanisms of the ethanol extract from a. sinica root (easr) in vitro. the antiviral activity of easr was examined by detecting the levels of hbsag, hbeag and extracellular hbv dnas in stable hbv-producing human hepatoblastoma hepg2 2.2.15 cells. we found that easr effectively suppresse ... | 2011 | 21738555 |
| new technologies for infectious screening of organ donors. | viral, bacterial, parasitic, prion, and fungal infections, although uncommon, have been transmitted via organ and tissue allografts. improved screening techniques for infectious diseases in organ donors have helped to reduce disease transmission. reports of clusters of donor-derived infections illustrate the need to improve the screening of tissue and organ donors. available microbiologic assays, including molecular tests, are generally designed for use as diagnostic tools in individuals believe ... | 2011 | 21839288 |
| epigenetic repression of e-cadherin expression by hepatitis b virus x antigen in liver cancer. | loss of e-cadherin is associated with acquisition of metastatic capacity. numerous studies suggest that histone deacetylation and/or hypermethylation of cpg islands in e-cadherin gene (cdh1) are major mechanisms responsible for e-cadherin silencing in different tumors and cancer cell lines. the hepatitis b virus (hbv)-encoded x antigen, hbx, contributes importantly to the development of hepatocellular carcinoma using multiple mechanisms. experiments were designed to test if in addition to cdh1 h ... | 2011 | 21706058 |
| effects of variant rs346473 in arhgap24 gene on disease progression of hbv infection in han chinese population. | host genetic, environmental and viral factors are classified as three categories that determine clinical outcomes of hepatitis b virus (hbv) infection. the objective of this study was to detect the associations between polymorphisms rs346473 and rs346482 in rho gtpase-activating protein 24 (arhgap24) gene and disease progression of hbv infection in han chinese population. these two snps were found by our dna pooling using affymetrix genome-wide human mapping snp6.0 array in hbv carriers, and ver ... | 2011 | 21823009 |
| inhibition of hepatitis b virus and human immunodeficiency virus (hiv-1) replication by warscewiczia coccinea (vahl) kl. (rubiaceae) ethanol extract. | the primary objective of this study was to search for natural products capable of inhibiting hepatitis b virus (hbv) replication. the research design, methods and procedures included testing hydro-alcoholic extracts (nôçë=ôçë66) of 31 species from the venezuelan amazonian rain forest on the cell line hepg2 2.2.15, which constitutively produces hbv. the main outcomes and results were as follows: the species euterpe precatoria, jacaranda copaia, jacaranda obtusifolia, senna silvestris, warscewiczi ... | 2011 | 21827337 |
| should chronic hepatitis b mothers breastfeed? a meta analysis. | hepatitis b virus (hbv) exists in the breast milk of chronic hepatitis b (chb) mothers. the authors use a meta-analytic technique to quantify the evidence of an association between breastfeeding and risk of chb infection among the infants vaccinated against hbv. | 2011 | 21708016 |
| hiv-related risk behaviors among a sample of men who have sex with men in puerto rico: an overview of substance use and sexual practices. | despite the growing impact of the human immunodeficiency virus (hiv) epidemic in puerto rico (pr), limited epidemiological research on men who have sex with men (msm) has been conducted. the aim of this study was to describe hiv-related risk behaviors in a sample of msm in pr. | 2011 | 21682148 |
| development of chronic hepatitis b virus infection in hepatitis b surface antigen negative hiv/hbv co-infected adults: a rare opportunistic illness. | changes in serologic status in human immunodeficiency virus (hiv)/hepatitis b virus (hbv) co-infected individuals with either isolated anti-hbc or resolved hbv infection have been reported, but the frequency of clinically meaningful long-term serologic changes is not well-defined. this study therefore, examined longitudinal serologic status for hepatitis b surface antigen (hbsag)-negative hiv/hbv co-infected participants in a large cohort. among 5,222 cohort participants, 347 (7%) were initially ... | 2011 | 21739443 |
| proteomic analysis of the interleukin-4 (il-4) response in hepatitis b virus-positive human hepatocelluar carcinoma cell line hepg2.2.15. | hepatitis b virus (hbv) infection is the leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. in recent decades, significant progress toward understanding the molecular virology and pathogenesis of hbv infection has been made. in addition, multiple treatment modalities have been developed for persons with hbv infection. in the present study, we demonstrated that il-4 inhibits the expression of hepatitis b surface antigen and hepatitis b e antigen in a hbv stably transfected h ... | 2011 | 21739463 |
| tgfbr3 polymorphisms and its haplotypes associated with chronic hepatitis b virus infection and age of hepatocellular carcinoma occurrence. | objective: hepatocellular carcinoma (hcc) is one of the most common cancers and is mainly caused by viral infections including hepatitis b virus (hbv). recently, the decreased expression level of the transforming growth factor, beta receptor iii (tgfbr3) gene, has been implicated in hcc and other human cancers. this study investigated whether tgfbr3 polymorphisms might be associated with hbv clearance and hcc occurrence. methods: this study identified 27 single nucleotide polymorphisms (snps) in ... | 2011 | 21829018 |
| synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides. | microwave-assisted optimized transglycosylation reactions were used to prepare eleven modified l-3'-azido-2',3'-dideoxypurine nucleosides. these l-nucleoside analogs were evaluated against hiv and hepatitis b virus. the l-3'-azido-2',3'-dideoxypurines nucleosides were metabolized to nucleoside 5'-triphosphates in primary human lymphocytes, but exhibited weak or no antiviral activity against hiv-1. the nucleosides were also inactive against hbv in hepg2 cells. pre-steady state kinetic experiments ... | 2011 | 21700368 |
| treating patients with hiv and hepatitis b and c infections: croatian dental students' knowledge, attitudes, and risk perceptions. | dentists and dental students can be exposed to the human immunodeficiency virus (hiv), hepatitis b virus (hbv), and hepatitis c virus (hcv) during routine work. the aims of this study were to assess a group of dental students' knowledge about hiv, hbv, and hcv infections; assess their attitudes and risk perceptions about the treatment of patients with hiv, hbv, and hcv; and identify factors associated with their knowledge and willingness to treat these patients. an anonymous survey was administe ... | 2011 | 21828306 |
| the hepatitis b virus-associated estrogen receptor alpha (eralpha) was regulated by microrna-130a in hepg2.2.15 human hepatocellular carcinoma cells. | the estrogen receptors (ers) play important roles in hepatocarcinogenesis, which is always fostered by persistent hepatitis b virus (hbv) infection. recent studies have linked micrornas (mirnas) to viral pathogenesis or oncogenesis. er╬▒ could lead to cell cycle progression or inhibition of apoptosis, while er╬▓ had opposite effects. here we proposed that hbv affected ers expression in viral oncogenesis, which might be triggered by mirnas. the protein expression of er╬▒ in hepg2.2.15 cells was m ... | 2011 | 21712254 |
| Co-infection with hepatitis viruses among HIV-infected individuals at a tertiary care centre in South India. | We studied the occurrence of hepatitis B (HBV) and hepatitis C (HCV) virus co-infections in human immunodeficiency virus (HIV)-infected individuals in a tertiary care centre. The occurrence of co-infections in our study was less than in the literature reported from the West. However, routine screening of these co-infections in HIV patients is recommended to avoid possible liver-related morbidity and mortality as a part of improving their quality of life. | 2011 | 21676983 |
| sixty-two severe and critical patients with 2009 influenza a (h1n1) in shanghai, china. | pandemic influenza a (h1n1) emerged rapidly in china in may 2009. preliminary comparisons with seasonal influenza suggest that pandemic 2009 influenza a (h1n1) disproportionately affects younger ages and causes generally mild disease. to characterize disease progress, comorbidities, and treatment outcomes among consecutive severe and critically ill patients in a hospital served as a reference center for the care of patients with h1n1 in shanghai, china. | 2011 | 21740773 |
| viral hepatitis infection and insulin resistance: a review of the pathophysiological mechanisms. | viral hepatitis is a common cause of morbidity in mexico. insulin resistance (ir) is related to the liver damage caused by some viral infections, especially chronic infections. chronic viral infection is an important risk factor for the development of type 2 diabetes mellitus, disease that is currently among the 10 main causes of morbidity and the most common cause of mortality. although several studies have reported an association between ir and hepatitis b virus or hepatitis c virus (hcv) infe ... | 2011 | 21877073 |
| Sudden death due to polyarteritis nodosa. | Classical polyarteritis nodosa (cPAN) refers to a rare, potentially fatal systemic transmural necrotizing vasculitis that usually affects medium-sized, and occasionally small, muscular arteries, primarily involves the kidneys, gastrointestinal tract, skin, nervous system, joints, and muscles, and is rarely, if ever, expressed in the lungs. The incidence of mortality has significantly decreased with recently developed treatment modalities, in particular antiviral medications. Sudden death due to ... | 2011 | 21983834 |
| restored circulating invariant nkt cells are associated with viral control in patients with chronic hepatitis b. | invariant nkt (inkt) cells are involved in the pathogenesis of various infectious diseases. however, their role in hepatitis b virus (hbv) infection is not fully understood, especially in human species. in this study, 35 chronic hepatitis b (chb) patients, 25 inactive carriers (ic) and 36 healthy controls (hc) were enrolled and the proportions of circulating inkt cells in fresh isolated peripheral blood mononuclear cells (pbmc) were detected by flow cytometry. a longitudinal analysis was also co ... | 2011 | 22194934 |
| viral double-strand rna-binding proteins can enhance innate immune signaling by toll-like receptor 3. | toll-like receptor 3 (tlr3) detects double-stranded (ds) rnas to activate innate immune responses. while poly(i:c) is an excellent agonist for tlr3 in several cell lines and in human peripheral blood mononuclear cells, viral dsrnas tend to be poor agonists, leading to the hypothesis that additional factor(s) are likely required to allow tlr3 to respond to viral dsrnas. tlr3 signaling was examined in a lung epithelial cell line by quantifying cytokine production and in human embryonic kidney cell ... | 2011 | 22016778 |
| A shot at hepatitis prevention. | Recent trends suggest that the prevalence of hepatitis infection has declined in populations vaccinated against the hepatitis viruses. Still, with an estimated 20,000 new infections annually in the United States from human hepatitis A virus, as many as 100,000 annual cases of acute infection from hepatitis B virus, and more than 1 million individuals with chronic hepatitis B virus infection, there is room for further improvement. Although hepatitis A virus infection causes debilitating symptoms ... | 2011 | 22086888 |
| human chimeric upa mouse model to study hepatitis b and d virus interactions and preclinical drug evaluation. | no specific drugs are currently available against hepatitis delta virus (hdv), a defective virus leading to the most severe form of chronic viral hepatitis in men. the lack of convenient hdv infection models hampered the development of effective therapeutics. in this study, naïve and hepatitis b virus (hbv) chronically infected humanized upa/scid mice were employed to establish a small animal model of hbv/hdv co-infection and super-infection. for preclinical antiviral drug evaluation, myrcludex- ... | 2011 | 22031488 |
| abt-263 sensitizes trail-resistant hepatocarcinoma cells by downregulating the bcl-2 family of anti-apoptotic protein. | purpose: tumor necrosis factor-related apoptosis-inducing ligand (trail) is a promising anticancer agent due to its selective cytotoxicity to transformed cells. however, most human hepatocellular carcinomas (hcc) develop resistance to trail. thus, there is an urgent need to investigate the molecular targets and the underlying mechanisms that may be involved in overriding the resistance of tumor cells to trail. methods: ... | 2011 | 22037880 |
| establishment of a viral hepatitis surveillance system--pakistan, 2009-2011. | hepatitis a is thought to infect almost all persons living in pakistan by age 15 years, and hepatitis e is responsible for sporadic infections and outbreaks. the prevalence of hepatitis b virus (hbv) infection is estimated at 2.5% and the prevalence of hepatitis c virus (hcv) infection, estimated at 4.8%, is one of the highest rates in the world. hepatitis surveillance in pakistan has been syndromic, failing to confirm infection, distinguish among viruses, or collect information on risk factors. ... | 2011 | 21993343 |
| licensing virus-specific t cells to secrete the neutrophil attracting chemokine cxcl-8 during hepatitis b virus infection. | t cell functional plasticity helps tailor antiviral immunity during different phases of infections. we tested whether, during different phases of hbv infection, virus-specific t cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. multifunctional analysis of hbv-specific t cells during acute and chronic hbv infection revealed that hbv-specific t cells had the capacity to produce the neutrophil chemokine cxcl-8 but not il-17. cxcl- ... | 2011 | 21876747 |
| soluble human leukocyte antigen-g expression in hepatitis b virus infection and hepatocellular carcinoma. | we investigated soluble human leukocyte antigen-g (shla-g) expression according to the phases of hepatitis b virus (hbv) infections and hepatocellular carcinoma (hcc). a total of 267 sera from anti-hbs positive healthy individuals (n = 50), chronic hbv carriers (n = 45), as well as patients with active hepatitis b (n = 46), liver cirrhosis (lc, n = 46) and early stage hcc (n = 80) were collected and assayed for shla-g. relationships between shla-g levels and clinicopathologic parameters includin ... | 2011 | 22136460 |
| Differential Clinical and Virologic Impact of Hepatitis B Virus Genotypes B and C on HIV-Coinfected Patients Receiving Lamivudine-Containing Highly Active Antiretroviral Therapy. | Background. The impact of hepatitis B virus (HBV) genotypes B and C on the clinical, immunologic, and virologic outcomes of human immunodeficiency virus (HIV)-infected patients with chronic HBV infection remains largely unknown.Methods. Between January 1997 and December 2008, we enrolled 96 HIV-infected patients with HBV genotype B coinfection and 49 with genotype C coinfection; the patients were followed prospectively until December 2010. Clinical and immunologic outcomes in the context of HBV ... | 2011 | 22156858 |
| multi-analyte suspension arrays for the detection of common viruses: how viable are these assays in clinical laboratories? | this article assesses the viability of a recently described multi-analyte suspension array for the detection of herpes simplex viruses-1 and -2, cytomegalovirus, epstein-barr virus, human papillomavirus and hepatitis b virus. this methodology was identified by the authors as a means of providing rapid, high-throughput multiplex assays that were easy to use. when paired with pcr assays, multi-analyte suspension arrays have the ability to overcome drawbacks associated with conventional detection m ... | 2011 | 22029516 |
| klf15 activates hepatitis b virus gene expression and replication. | 2011 | 21503941 | |
| hbx sensitizes cells to oxidative stress-induced apoptosis by accelerating the loss of mcl-1 protein via caspase-3 cascade. | abstract: | 2011 | 21504623 |
| subversion of cellular autophagy machinery by hepatitis b virus for viral envelopment. | autophagy is a conserved eukaryotic mechanism that mediates the removal of long-lived cytoplasmic macromolecules and damaged organelles via a lysosomal degradative pathway. recently, a multitude of studies have reported that viral infections may have complex interconnections with the autophagic process. the findings reported here demonstrate that hepatitis b virus (hbv) can enhance the autophagic process in hepatoma cells without promoting protein degradation by the lysosome. mutation analysis s ... | 2011 | 21507968 |
| acog committee opinion no. 489: hepatitis b, hepatitis c, and human immunodeficiency virus infections in obstetrician-gynecologists. | in the health care setting, bloodborne pathogens such as the hepatitis b virus (hbv), hepatitis c virus, and human immunodeficiency virus (hiv) may be transmitted from infected patients to health care workers as well as from infected health care workers to patients. to reduce the risk of transmission, all practicing obstetrician-gynecologists should receive the hbv vaccine. obstetrician-gynecologists infected with hbv, hepatitis c virus, or hiv are advised to follow the updated society for healt ... | 2011 | 21508783 |
| suspected interaction between sorafenib and haart in an hiv-1 infected patient: a case report. | sorafenib prolongs survival of patients with unresectablehepatocellular carcinoma (hcc). it is likely to be used in human immunodeficiency virus (hiv) infected patients. interactions between sorafenib and highly active antiretroviral therapy (haart) have not been studied yet. we report a case of serious adverse effects in anhiv-1 patient co-infected with hbv. | 2011 | 21510306 |
| cross-species transmission of gibbon and orangutan hepatitis b virus to upa/scid mice with human hepatocytes. | to investigate the potential of cross-species transmission of non-human primate hbv to humans, severe combined immunodeficiency mice transgenic for urokinase-type plasminogen activator, in which the mouse liver has been engrafted with human hepatocytes, were inoculated with non-human primate hbv. hbv-dna positive serum samples from a gibbon or orangutan were inoculated into 6 chimeric mice. hbv-dna, hepatitis b surface antigen (hbsag), and hb core-related antigen in sera and hbv cccdna in liver ... | 2011 | 21510984 |
| multiplexed detection of nucleic acids in a combinatorial screening chip. | multiplexed diagnostic testing has the potential to dramatically improve the quality of healthcare. simultaneous measurement of health indicators and/or disease markers reduces turnaround time and analysis cost and speeds up the decision making process for diagnosis and treatment. at present, however, most diagnostic tests only provide information on a single indicator or marker. development of efficient diagnostic tests capable of parallel screening of infectious disease markers could significa ... | 2011 | 21512691 |
| microrna response to environmental mutagens in liver. | during the recent few years, micrornas emerged as key molecules in the regulation of mammalian cell functions. it was also shown that their altered expression can promote pathologic conditions, such as cancer and other common diseases. because environmental exposure to biological, chemical or physical agents may be responsible for human diseases, including cancer, uncovering relationships between exposure to environmental carcinogens and expression of micrornas may help to disclose early mechani ... | 2011 | 21514310 |
| epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. | epigenetic mechanisms maintain heritable changes in gene expression and chromatin organization over many cell generations. importantly, deregulated epigenetic mechanisms play a key role in a wide range of human malignancies, including liver cancer. hepatocellular carcinoma (hcc), which originates from the hepatocytes, is by far the most common liver cancer, with rates and aetiology that show considerable geographic variation. various environmental agents and lifestyles known to be risk factors f ... | 2011 | 21514401 |
| efficient and rapid purification of drug- and gene-carrying bio-nanocapsules, hepatitis b virus surface antigen l particles, from saccharomyces cerevisiae. | bio-nanocapsules (bncs) are hollow particles (approx. 50nm diameter) consisting of hepatitis b virus surface antigen (hbsag) large (l, pre-s1+pre-s2+s) proteins embedded in a unilamellar liposome, sharing the same transmembrane s region with an immunogen of hepatitis b vaccine (i.e., hbsag small (s) protein particle). bncs can incorporate drugs and genes into the hollow space and systemic administration of the bncs can deliver the products to human liver via the human hepatocyte-specific recepto ... | 2011 | 21515381 |
| [identification of ubiquitously expressed transcript as the potential interactor of hepatitis b virus polymerase.] | objective: to investigate the function of hepatitis b virus polymerase (hbv pol) in the viral life cycle by screening the proteins interacting with hbv polymerase. methods: the hbv pol gene was constructed into the pgbkt7 vector. gal4 yeast two-hybrid system was used to screen the human liver cdna library to obtain proteins which interacted with hbv pol. gst-pull down assay was applied to confirm the protein interactions. results: ubiquitously expressed transcript (uxt) was selected by the yeast ... | 2011 | 21515470 |
| tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer. | the poor prognosis of liver cancer demands the development of new diagnostic markers and therapeutic strategies. cancer/testis (ct) antigens are expressed in the testis and cancerous tissues, but not in adult somatic cells. given their tumor-specific expression, ct antigens are potential molecular markers for tumor diagnosis and targets for cancer immunotherapy. to identify novel ct antigens for liver cancer, we examined mrna expression of hitherto unknown ct antigen candidates, tudor domain-con ... | 2011 | 21515969 |
| targeting hepatitis b virus and human papillomavirus induced carcinogenesis: novel patented therapeutics. | viral infections leading to carcinogenesis tops the risk factors list for the development of human cancer. the decades of research has provided ample scientific evidence that directly links 10-15% of the worldwide incidence of human cancers to the infections with seven human viruses. moreover, the insights gained into the molecular pathogenetic and immune mechanisms of hepatitis b virus (hbv) and human papillomavirus (hpv) viral transmission to tumour progression, and the identification of their ... | 2011 | 21517743 |
| multiple cerebral arterial stenosis associated with hepatitis b virus infection. | there are conflicting findings regarding the association between hepatitis b (hb) virus (hbv) infection and atherosclerosis. | 2011 | 21519526 |
| characterization of woodchuck apolipoprotein a-i: a new tool for drug delivery and identification of altered isoforms in the woodchuck chronic hepatitis model. | apolipoprotein a-i (apoa-i) is the major protein component of high density lipoprotein (hdl) particles in serum, and participates in the reverse transport of cholesterol from tissues to the liver for excretion. the natural hdl tropism to the liver and cancer cells has been used extensively to target encapsulated drugs. the alteration of the plasmatic isoforms of apoa-i is a hallmark of chronic hepatitis and hepatocarcinoma in mice and humans. woodchucks infected with the woodchuck hepatitis viru ... | 2011 | 21520143 |
| modulation of hepatitis b virus replication and hepatocyte differentiation by microrna-1. | micrornas (mirnas) are highly conserved small noncoding rnas participating in regulation of various cellular processes. viruses have been shown to utilize cellular mirnas to increase their replication in host cells. until now, the role of mirnas in hepatitis b virus (hbv) replication has remained largely unknown. in this study, a number of mirna mimics were transfected into hepatoma cell lines with hbv replication. it was noted that microrna-1 (mir-1) transfection resulted in a marked increase o ... | 2011 | 21520166 |
| prevalence of hepatitis b and hepatitis c virus infection in human of mymensingh, bangladesh. | hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are among the most frequent viral infections in humans, and represent a major global public health problem, especially in asia. hbv- and hcv-related chronic hepatitis is the main causes of cirrhosis and hepatocellular carcinoma (hcc) of liver that are responsible for a high rate of morbidity and mortality. the study was done to analyze the prevalence of hbv and hcv among the people of mymensingh city, bangladesh. this cross sectional ... | 2011 | 21522084 |
| a conserved arginine residue in the terminal protein domain of hepatitis b virus polymerase is critical for rna pregenome encapsidation. | hepadnaviruses, including human hepatitis b virus (hbv) and duck hepatitis b virus (dhbv), replicate their dna genome through reverse transcription. although hepadnaviral polymerase (pol) is distantly related to retroviral rts, some of its features are distinct. in particular, besides the rt and rnase h domain, which are commonly encoded by retroviral rts, the n-terminally extended terminal protein (tp) domain confers unique features such as protein priming capability. importantly, the tp domain ... | 2011 | 21525211 |
| real time monitoring of antigenicity development of hbsag virus-like particles (vlps) during heat- and redox-treatment. | the hepatitis b virus major surface antigen (hbsag) is a cysteine-rich, membrane-bound protein which self-assembles into 22-nm spherical virus-like particles (vlps). while this vlp based human vaccine has been demonstrated to be safe and efficacious since 1986, the structural and exact molecular basis for its antigenic determinants has not been elucidated. maturation of the yeast-derived purified vlps was characterized for the changes in 37 their biophysical properties [7]. using rapid and label ... | 2011 | 21527246 |
| hepatitis b and c infection and liver disease trends among human immunodeficiency virus-infected individuals. | to examine trends in and correlates of liver disease and viral hepatitis in an human immunodeficiency virus (hiv)-infected cohort. | 2011 | 21528052 |
| breastfeeding of newborns by mothers carrying hepatitis b virus: a meta-analysis and systematic review. | objective: to perform a systematic review of prospective studies to confirm the role of breastfeeding in mother-to-child transmission (mtct) of hepatitis b virus (hbv). data sources: a database was constructed from medline, embase, cochrane library, national science digital library, and china biological medicine database and through contact with experts in this field from january 1, 1990, to august 31, 2010. study selection: all studies were peer reviewed and met the preset inclusion standards. ... | 2011 | 21536948 |
| understanding the host genetics of chronic hepatitis b and c. | the outcome of hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are heterogeneous, ranging from an asymptomatic self-limiting infection to cirrhosis and hepatocellular carcinoma. several viral environmental and demographic variables have been identified as determinants of disease outcome, but these fail to explain a large proportion of the variability. evidence from twin studies suggests that the host genetic background is an important contributor to disease outcome. identification ... | 2011 | 21538279 |
| crystal structures of hepatitis b virus core 18-27 peptide bound to multiple hla-a2 alleles: implications for therapeutic vaccine design. | binding of specific antigenic peptides with hla molecules is a prerequisite for the initiation of t-cell responses and structural information about the peptide-hla complex is essential for the detailed understanding of such interactions. hla-a2 is the most prevalent hla allele globally but aside from a*02:01 there is a significant lack of crystal structures, particularly for alleles that occur in high frequencies among asian populations. here, we report three hla-a2 structures with the immunodom ... | 2011 | 21538979 |
| hepatitis b virus infection from an evolutionary point of view: how viral, host, and environmental factors shape genotypes and subgenotypes. | hepatitis b virus (hbv) has an overwhelming distribution in the world and causes important human health problems. it has infected one-third of the global population and more than 350 million people are chronic carriers. several aspects of hbv infection confer adaptive advantages that lead to a highly efficient dissemination of the virus through different routes of transmission. hbv genotypes and subgenotypes have been associated with differences in clinical and virological characteristics, indic ... | 2011 | 21539937 |
| the cost-effectiveness of screening for chronic hepatitis b infection in the united states. | (see the editorial commentary by lo re iii, on pages 1307-1309.) background. hepatitis b virus (hbv) continues to cause significant morbidity and mortality in the united states. current guidelines suggest screening populations with a prevalence of ≥2%. our objective was to determine whether this screening threshold is cost-effective and whether screening lower-prevalence populations might also be cost-effective. methods. we developed a markov state transition model to examine screening of asympt ... | 2011 | 21540206 |
| profile of immunoglobulins a, g, and m during breast milk maturation in a tropical area (gabon). | objectives: to study the maturation of breast milk by the course of immunoglobulins a, g and m during the first three weeks of breast feeding. material and methods: this longitudinal and prospective survey took place from august to october, 2007, in libreville, the capital of gabon. the population comprised women with no significant medical history who had given birth in the obstetrics department of center hospital of libreville. women who delivered at home, had stillbirths, or infants positive ... | 2011 | 21550925 |
| serum fatty acid synthase concentration is increased in patients with hepatitis viral infection and may assist in the prediction of liver steatosis. | background: liver steatosis is frequent in patients with chronic hepatitis viral infections. intracellular fatty acid synthase (fasn) seems to play a substantial role in its pathogenesis. fasn can also be found in circulation and is significantly increased in hiv-infected individuals, especially if they are co-infected with hepatitis c virus (hcv). objectives: to assess whether serum fasn concentration is also increased in patients with chronic hepatitis viral infections and its relationship wit ... | 2011 | 21555238 |
| use of rna interference to modulate liver adenoma development in a murine model transgenic for hepatitis b virus. | chronic hepatitis b virus (hbv) infection is closely related to the development of severe liver complications, including hepatocellular carcinoma. in previous studies, we reported that in vivo long-term hbv suppression in transgenic mice can be achieved without apparent toxicity by short hairpin rna sequentially delivered using adeno-associated viral (aav) vectors of different serotypes. our goal herein was to address the clinical utility of this delivery system and, in particular, to determine ... | 2011 | 21562593 |
| role of micrornas in hepatitis b virus replication and pathogenesis. | the hepatitis b virus (hbv) is a widespread human pathogen and chronic hbv infection is a major risk factor for hepatocellular carcinoma (hcc). the role of microrna (mirna) in the replication and pathogenesis was reviewed. so far none of hbv-encoded mirna has been identified. cellular mirnas have shown able to regulate hbv at the transcription level either by targeting to cellular transcriptions factors required for hbv gene expression, or by a directly binding to hbv transcripts. we also summar ... | 2011 | 21565290 |
| up-regulation of foxo4 mediated by hepatitis b virus x protein confers resistance to oxidative stress-induced cell death. | the hepatitis b virus x (hbx) protein, a regulatory protein of the hepatitis b virus (hbv), has been shown to generate reactive oxygen species (ros) in human liver cell lines; however, the mechanism by which cells protect themselves under this oxidative stress is poorly understood. here, we show that hbx induces the up-regulation of forkhead box class o 4 (foxo4) not only in chang cells stably expressing hbx (chang-hbx) but also in primary hepatic tissues from hbx-transgenic mice. hbx also incre ... | 2011 | 21567078 |
| identification of suitable reference genes for qrt-pcr analysis of circulating micrornas in hepatitis b virus-infected patients. | circulating micrornas (mirnas) were found to exist in serum/plasma in a highly stable, cell-free form, and aberrantly expressed in many human diseases. currently, the expression levels of circulating mirnas are estimated by quantitative real-time polymerase chain reaction. however, no study has systematically evaluated reference genes for evaluating circulating microrna expression. this study describes the identification and characterization of an appropriate reference gene for the normalization ... | 2011 | 21567136 |
| interference of replication between hepatitis b and c viruses in patients infected with hiv. | the clinical and cellular interactions between hepatitis b virus (hbv) and hepatitis c virus (hcv) were investigated in patients co-infected with the human immunodeficiency virus (hiv). one hundred ninety-nine patients followed for 6 years were evaluated to compare the level of hbv dna and hcv rna in patients co-infected with hiv and hbv, and patients co-infected with hiv, hbv, and hcv. a full-length hbv genome and hcv jfh1 rna were co-transfected into huh-7.5.1 cells in vitro to examine the imp ... | 2011 | 21567419 |
| upregulated microrna-29a by hepatitis b virus x protein enhances hepatoma cell migration by targeting pten in cell culture model. | hepatitis b virus x protein (hbx) plays important roles in the development of hepatocellular carcinoma (hcc). micrornas (mirnas) contribute to cancer development by acting as oncogenes or tumor suppressors. previously, we reported that hbx was able to promote the migration of hepatoma hepg2 cells. however, the regulation of mirnas in the development of hbv-related hcc is poorly understood. in the present study, we reported that mir-29a was a novel regulator of migration of hepatoma cells mediate ... | 2011 | 21573166 |
| inhibition of hepatitis b virus (hbv) by lna-mediated nuclear interference with hbv dna transcription. | silencing target genes with small regulatory rnas is widely used to investigate gene function and therapeutic drug development. recently, triplex-based approaches have provided another attractive means to achieve targeted gene regulation and gene manipulation at the molecular and cellular levels. nuclear entry of oligonucleotides and enhancement of their affinity to the dna targets are key points of such approaches. in this study, we developed lipid-based transport of a locked-nucleic-acid (lna) ... | 2011 | 21596023 |
| establishment and characterization of a spontaneously immortalized trophoblast cell line (hpt-8) and its hepatitis b virus-expressing clone. | background most trophoblast cell lines currently available to study vertical transmission of hepatitis b virus (hbv) are immortalized by viral transformation. our goal was to establish and characterize a spontaneously immortalized human first-trimester trophoblast cell line and its hbv-expressing clone. methods chorionic villi of asian human first-trimester placentae were digested with trypsin and collagenase i to obtain the primary trophoblast cell culture. a spontaneously immortalized trophobl ... | 2011 | 21596708 |
| molecular characterization and phylogenetic analysis of full-genome hbv subgenotype d3 sequences from serbia. | hepatitis b virus (hbv) is classified into 8 genotypes with distinct geographical distribution. genotype d (hbv/d) has the widest distribution area and is comprised of 7 subgenotypes. subgenotypes d1, d2 and d3 appear worldwide, while d4-d7 have a more restricted distribution. within the mediterranean area, hbv/d and subgenotype d3 are the most prevalent. the purpose of this study was to characterize the full genome of serbian hbv/d3 isolates by comparison and phylogenetic analysis with hbv/d3 s ... | 2011 | 21601012 |
| [development of an amplified luminescent proximity homogeneous immunoassay kit for detecting human hepatitis b virus e antibody.] | objective: to develop an amplified luminescent proximity homogeneous immunoassay (alphalisa) kit for the detection of human hepatitis b virus e antibody (hbeab). methods: the neutralizing and competitive inhibition method was used to develop the alphalisa kit for detection of serum hbeab. results: the working range of the kit was 0.003-16 ncu/ml with a sensitivity up to 0.003 ncu/ml. the intra- and inter-assay coefficient of variation was 5.3% and 6.8%, respectively. the kit showed no cross-reac ... | 2011 | 21602130 |
| seroprevalence of transfusion-transmissible infections and evaluation of the pre-donation screening performance at the provincial hospital of tete, mozambique. | abstract: background: the world health organization recommends universal and quality-controlled screening of blood donations for the major transfusion-transmissible infections (ttis): human immunodeficiency virus (hiv), hepatitis b virus (hbv), hepatitis c virus (hcv) and syphilis. the study objectives were to determine the seroprevalence of these ttis among blood donors at the provincial hospital of tete, mozambique, and to assess the local pre-donation screening performance. methods: all conse ... | 2011 | 21605363 |
| protein expression and fucosylated glycans of the serum haptoglobin-{beta} subunit in hepatitis b virus-based liver diseases. | glycosylation, which regulates the configuration and function of glycoproteins, is the most important post-translational modification. the aim of this study was to observe the differential patterns in glycan and protein parts of the serum haptoglobin-β subunit (hp-β) purified from patients with hepatitis b virus (hbv) infection, liver cirrhosis (lc), or hepatocellular carcinoma (hcc). 2-d gel electrophoresis and multiplexed proteomics staining technique were employed to investigate whether the ... | 2011 | 21606158 |
| infections in hemodialysis: a concise review - part 1: bacteremia and respiratory infections. | hemodialysis (hd) patients are particularly predisposed to infections. it seems that the hd procedure per se as well as disturbances in both innate and adaptive immunity significantly contribute to this susceptibility. infections are the major cause of morbidity and the second cause of death following cardiovascular events in hd patients. episodes of bacteremia and pneumonia account for the majority of severe infections in this population. in addition to these bacterial infections another common ... | 2011 | 21607029 |
| association of hla-g 3' utr 14-bp insertion/deletion polymorphism with hepatocellular carcinoma susceptibility in a chinese population. | the 14-bp insertion/deletion (indel) polymorphism located in the 3' utr of the human leukocyte antigen-g (hla-g) gene plays a role in several autoimmune and chronic inflammatory diseases. hla-g expression is associated with hepatocellular carcinoma (hcc) prognosis, especially in early stage, with high expression independently associated with shortened overall survival and increased tumor recurrence. in the present study, we carried out a case-control study in a chinese population (318 cases and ... | 2011 | 21612396 |
| anal and oral human papillomavirus (hpv) infection in hiv infected subjects in northern italy: a longitudinal cohort study among men who have sex with men. | abstract: background: a study including 166 subjects was performed to investigate the frequency and persistence over a 6-month interval of concurrent oral and anal human papillomavirus (hpv) infections in human immunodeficiency virus (hiv)-infected men who have sex with men (msm). methods: patients with no previously documented hpv-related anogenital lesion/disease were recruited to participate in a longitudinal study. polymerase chain reaction (pcr) was performed to detect hpv from oral and ana ... | 2011 | 21612634 |