Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| helicobacter pylori caga phosphorylation-independent function in epithelial proliferation and inflammation. | caga, a major virulence factor of helicobacter pylori (hp), is delivered into gastric epithelial cells and exists in phosphorylated and nonphosphorylated forms. the biological activity of the phosphorylated form is well established; however, function(s) of the nonphosphorylated form remain elusive. here, we report that a conserved motif in the c-terminal region of caga, which is distinct from the epiya motifs used for phosphorylation and which we designate crpia (conserved repeat responsible for ... | 2009 | 19154985 |
| cdx2 expression is induced by helicobacter pylori in ags cells. | 2009 | 18991163 | |
| the peopling of the pacific from a bacterial perspective. | two prehistoric migrations peopled the pacific. one reached new guinea and australia, and a second, more recent, migration extended through melanesia and from there to the polynesian islands. these migrations were accompanied by two distinct populations of the specific human pathogen helicobacter pylori, called hpsahul and hspmaori, respectively. hpsahul split from asian populations of h. pylori 31,000 to 37,000 years ago, in concordance with archaeological history. the hpsahul populations in ne ... | 2009 | 19164753 |
| differences in genome content among helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes. | helicobacter pylori establishes a chronic infection in the human stomach, causing gastritis, peptic ulcer, or gastric cancer, and more severe diseases are associated with virulence genes such as the cag pathogenicity island (pai). the aim of this work was to study gene content differences among h. pylori strains isolated from patients with different gastroduodenal diseases in a mexican-mestizo patient population. h. pylori isolates from 10 patients with nonatrophic gastritis, 10 patients with du ... | 2009 | 19237517 |
| effect of helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells. | host cell responses to helicobacter pylori infection are complex and incompletely understood. here, we report that autophagy is induced within human-derived gastric epithelial cells (ags) in response to h. pylori infection. these autophagosomes were distinct and different from the large vacuoles induced during h. pylori infection. autophagosomes were detected by transmission electron microscopy, conversion of lc3-i to lc3-ii, gfp-lc3 recruitment to autophagosomes, and depended on atg5 and atg12. ... | 2009 | 19164948 |
| epidermal growth factor receptor activation protects gastric epithelial cells from helicobacter pylori-induced apoptosis. | helicobacter pylori infection disrupts the balance between gastric epithelial cell proliferation and apoptosis, which is likely to lower the threshold for the development of gastric adenocarcinoma. h pylori infection is associated with epidermal growth factor (egf) receptor (egfr) activation through metalloproteinase-dependent release of egfr ligands in gastric epithelial cells. because egfr signaling regulates cell survival, we investigated whether activation of egfr following h pylori infectio ... | 2009 | 19250983 |
| helicobacter pylori mutants defective in the clpp atp-dependant protease and the chaperone clpa display reduced macrophage and murine survival. | the atp-dependent caseinolytic proteases (clp) are important in resistance against environmental stresses, antibiotic treatments and host immune defences for a number of pathogenic bacteria. clpp is the proteolytic subunit, whilst clpa acts both as a chaperone and as an atpase driving the degradation of damaged or mis-made proteins. the gastric pathogen helicobacter pylori infects approximately half of the world's population and can cause gastric or duodenal ulcers, gastric malignancies and muco ... | 2009 | 18992803 |
| importance of egf receptor, her2/neu and erk1/2 kinase signalling for host cell elongation and scattering induced by the helicobacter pylori caga protein: antagonistic effects of the vacuolating cytotoxin vaca. | helicobacter pylori is the causative agent of gastric pathologies ranging from chronic gastritis to peptic ulcers and even cancer. virulent strains carrying both the cag pathogenicity island (cagpai) and the vacuolating cytotoxin vaca are key players in disease development. the cagpai encodes a type iv secretion system (t4ss) which forms a pilus for injection of the caga protein into gastric epithelial cells. injected caga undergoes tyrosine phosphorylation and induces actin-cytoskeletal rearran ... | 2009 | 19046339 |
| helicobacter pylori vaca-induced inhibition of gsk3 through the pi3k/akt signaling pathway. | helicobacter pylori vaca toxin contributes to the pathogenesis and severity of gastric injury. we found that incubation of az-521 cells with vaca resulted in phosphorylation of protein kinase b (akt) and glycogen synthase kinase-3beta (gsk3beta) through a pi3k-dependent pathway. following phosphorylation and inhibition of gsk3beta,beta-catenin was released from a gsk3beta/beta-catenin complex, with subsequent nuclear translocation. methyl-beta-cyclodextrin (mcd) and phosphatidylinositol-specific ... | 2009 | 18996844 |
| a single nucleotide change affects fur-dependent regulation of sodb in h. pylori. | helicobacter pylori is a significant human pathogen that has adapted to survive the many stresses found within the gastric environment. superoxide dismutase (sodb) is an important factor that helps h. pylori combat oxidative stress. sodb was previously shown to be repressed by the ferric uptake regulator (fur) in the absence of iron (apo-fur regulation) [1]. herein, we show that apo regulation is not fully conserved among all strains of h. pylori. apo-fur dependent changes in sodb expression are ... | 2009 | 19399190 |
| does the expression of cyclin e, prb, and p21 correlate with prognosis in gastric adenocarcinoma? | cyclin e is a protein that plays a key role in the g1 --> s transition of the normal cell cycle. the product of retinoblastoma gene (prb) is the master regulator of entry into the cell cycle and p21 protein is a cyclin-dependent kinase inhibitor that disturbs the progression through the cell cycle. the expression of these proteins, among many others, is being deregulated in tumorogenesis. the aim of this study was to investigate whether cyclin e, prb, and p21 can be used as prognostic indicators ... | 2009 | 19058005 |
| identification of small noncoding rnas in helicobacter pylori by a bioinformatics-based approach. | small noncoding rnas (srnas) are a group of regulatory rna molecules normally without a protein-coding function. in recent years, the importance of srnas as mediators of gene expression in bacteria has begun to be recognized. more than 70 srnas have been known in escherichia coli. however, little is known about srnas in helicobacter pylori, a human pathogen associated with gastric diseases. here, we systematically identified srnas in the h. pylori genome by a computational approach based on gene ... | 2009 | 19123032 |
| genome sequence analysis of helicobacter pylori strains associated with gastric ulceration and gastric cancer. | persistent colonization of the human stomach by helicobacter pylori is associated with asymptomatic gastric inflammation (gastritis) and an increased risk of duodenal ulceration, gastric ulceration, and non-cardia gastric cancer. in previous studies, the genome sequences of h. pylori strains from patients with gastritis or duodenal ulcer disease have been analyzed. in this study, we analyzed the genome sequences of an h. pylori strain (98-10) isolated from a patient with gastric cancer and an h. ... | 2009 | 19123947 |
| methylation of p16ink4a and mitotic arrest defective protein 2 (mad2) genes in gastric marginal-zone b-cell lymphomas. | products of cyclin-dependent kinase inhibitor p16(ink4a)and mitotic arrest defective protein 2 (mad2) genesare key regulator proteins at the g1 restriction point and mitotic checkpoint of the cell cycle. the objective of this study was to investigate the role of promoter methylation of p16(ink4a) and mad2 genes in gastric marginal-zone b-cell lymphoma (mzbcl). | 2009 | 19174606 |
| expression of helicobacter pylori caga domains by library-based construct screening. | highly pathogenic strains of helicobacter pylori use a type iv secretion system to inject the caga protein into human gastric cells. there, caga associates with the inner side of the membrane and is tyrosine-phosphorylated at epiya motifs by host kinases. the phosphorylation triggers a series of interactions between caga and human proteins that result in a dramatic change of cellular morphology. structural and functional analyses of the protein have proved difficult, due to the proteolytically s ... | 2009 | 19143840 |
| the relationship between updated sydney system score and ldl cholesterol levels in patients infected with helicobacter pylori. | helicobacter pylori (h. pylori) chronically infects the human stomach and may cause extra-gastrointestinal diseases. the role of h. pylori in the pathogenesis of atherosclerosis and its effect on lipids remains controversial. the aim of this study was to examine lipid levels in patients with and without h. pylori infection. | 2009 | 18649137 |
| parp-1 val762ala polymorphism, caga+ h. pylori infection and risk for gastric cancer in han chinese population. | parp-1 plays important role in the ber (base excision repair) and maintenance of genomic integrity. previous study found the val762ala genetic variant in the parp-1 gene contributed to susceptibility of some cancers and decreased parp-1 enzyme activity in response to oxidative damage. helicobacter pylori (h. pylori) infection was thought to be one of the major causes of gastric cancer. in this study, we investigated the association between the parp-1 val762ala polymorphism, caga(+) h. pylori inf ... | 2009 | 18716896 |
| ulcers and gastritis. | 2009 | 19058127 | |
| tight junctions as targets of infectious agents. | the epithelial barrier is a critical border that segregates luminal material from entering tissues. essential components of this epithelial fence are physical intercellular structures termed tight junctions. these junctions use a variety of transmembrane proteins coupled with cytoplasmic adaptors, and the actin cytoskeleton, to attach adjacent cells together thereby forming intercellular seals. breaching of this barrier has profound effects on human health and disease, as barrier deficiencies ha ... | 2009 | 19059200 |
| helicobacter pylori: pathological mechanism involved in gastric colonization. | since 1982, when marshall and warren highlighted the presence of h. pylori at the apical pole of the epithelial gastric cells, the medical literature has registered a cascade of subsequent researches concerning this amazing bacterium, its action on the human body and the body response. the apogee of these studies and conclusions about the pathogenic role of hp was touched with its certain recognition as class one carcinogenic agent (peura 1997, who), becoming the first bacteria with such an acti ... | 2009 | 21179915 |
| infectious causes of chronic immune thrombocytopenia. | persistent thrombocytopenia may be the consequence of chronic infections with hepatitis c virus (hcv), human immunodeficiency virus (hiv), and helicobacter pylori, and should be considered in the differential diagnosis of primary immune thrombocytopenia (itp). studies have shown that on diagnosis of infections, treatment of the primary disease often results in substantial improvement or complete recovery of the thrombocytopenia. in patients with thrombocytopenia due to hcv-related chronic liver ... | 2009 | 19932434 |
| [effect of cyp2c19 gene polymorphism on eradication treatment efficacy of helicobacter pylori infection]. | 2009 | 19961004 | |
| clinicopathological characteristics of primary gastric t-cell lymphoma. | to investigate the clinicopathological characteristics of 20 primary gastric t-cell lymphoma (gtcl) cases without human t-lymphotropic virus type i infection in japan, a non-endemic area for coeliac disease. | 2009 | 20002766 |
| host-dependent lewis (le) antigen expression in helicobacter pylori cells recovered from leb-transgenic mice. | variation of surface antigen expression is a mechanism used by microbes to adapt to and persist within their host habitats. helicobacter pylori, a persistent bacterial colonizer of the human stomach, can alter its surface lewis (le) antigen expression. we examined h. pylori colonization in mice to test the hypothesis that host phenotype selects for h. pylori (le) phenotypes. when wild-type and le(b)-expressing transgenic fvb/n mice were challenged with h. pylori strain hp1, expressing le(x) and ... | 2009 | 20008521 |
| helicobacter pylori--a seasoned pathogen by any other name. | helicobacter pylori is a well known inhabitant of human stomach which is linked to peptic ulcer disease and gastric adenocarcinoma. it was recently shown in several studies that h. pylori can be harnessed as a surrogate marker of human migration and that its population structure and stratification patterns exactly juxtapose to those of homo sapiens. this is enough a testimony to convey that h. pylori may have coevolved with their host. several protective effects of h. pylori colonization have be ... | 2009 | 20030808 |
| activation of the abundant nuclear factor poly(adp-ribose) polymerase-1 by helicobacter pylori. | modification of eukaryotic proteins is a powerful strategy used by pathogenic bacteria to modulate host cells during infection. previously, we demonstrated that helicobacter pylori modify an unidentified protein within mammalian cell lysates in a manner consistent with the action of a bacterial adp-ribosylating toxin. here, we identified the modified eukaryotic factor as the abundant nuclear factor poly(adp-ribose) polymerase-1 (parp-1), which is important in the pathologies of several disease s ... | 2009 | 19897724 |
| evidence for transepithelial dendritic cells in human h. pylori active gastritis. | despite extensive experimental investigation stressing the importance of bacterial interaction with dendritic cells (dcs), evidence regarding direct interaction of helicobacter pylori or its virulence products with dcs in the human gastric mucosa is lacking. | 2009 | 19702851 |
| helicobacter pylori moves through mucus by reducing mucin viscoelasticity. | the ulcer-causing gastric pathogen helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. h. pylori survives in acidic conditions by producing urease, which catalyzes hydrolysis of urea to yield ammonia thus elevating the ph of its environment. however, the manner in which h. pylori is able to swim through the viscoelastic mucus gel that coats the stomach wall remains poorly understood. previous rheology studies on gastric mucin, the key vi ... | 2009 | 19706518 |
| neutrophil gelatinase-associated lipocalin (ngal/lcn2) is upregulated in gastric mucosa infected with helicobacter pylori. | helicobacter pylori infection is one of the most significant risk factors for gastric cancer. the infection is established early in life and persists lifelong leading to a sustained chronic inflammation. iron is essential for most living organisms. bacteria use several mechanisms to acquire iron from their hosts, including the synthesis of the potent iron chelators known as siderophores. hosts cells may express the siderophore-binding protein neutrophil gelatinase-associated lipocalin (ngal/lipo ... | 2009 | 19727808 |
| increased expression and cellular localization of lipocalin-type prostaglandin d synthase in helicobacter pylori-induced gastritis. | immunological responses in the host can result in different disease outcomes of helicobacter pylori-induced gastritis. prostaglandin e2 derived from cyclooxygenase (cox) and prostaglandin e synthase contribute to gastric protection. recently, prostaglandin d2 was shown to be involved in host immunity by chemotactic activity through chemoattractant receptor-homologous molecule expressed on th2 cells (crth2), but its role in h. pylori-induced gastritis has not been clarified. we determined the exp ... | 2009 | 19768745 |
| genetic factors associated with intestinal metaplasia in a high risk singapore-chinese population: a cohort study. | intestinal metaplasia (im) is an important precursor lesion in the development of gastric cancer (gc). the aim of this study was to investigate genetic factors previously linked to gc risk for their possible association with im. a total of 18 polymorphisms in 14 candidate genes were evaluated in a singapore-chinese population at high risk of developing gc. | 2009 | 19822020 |
| geographic distribution of methyltransferases of helicobacter pylori: evidence of human host population isolation and migration. | helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. this ubiquitous association between h. pylori and humans is thought to be present since the origin of modern humans. the h. pylori genome encodes for an exceptional number of restriction and modifications (r-m) systems. to evaluate if r-m systems are an adequate tool to determine the geographic distribution of h. pylori strains, we typed 221 strains from africa, america, asia, and ... | 2009 | 19737407 |
| interaction of helicobacter pylori with genetic variants in the mdm2 promoter, is associated with gastric cancer susceptibility in chinese patients. | mdm2 is a major negative regulator of p53, and a single nucleotide polymorphism (snp) in the mdm2 promoter region snp309 (rs2279744) has been shown to increase the affinity of the transcriptional activator sp1, resulting in elevated mdm2 transcription and expression in some cancers. the aim of this study was to determine whether snp309 is associated with susceptibility to gastric cancer in chinese patients. | 2009 | 19751436 |
| helicobacter pylori hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo. | helicobacter pylori-derived peptide rpl1 aa 2-20 (hp(2-20)) in addition to its antimicrobial action exerts several immunomodulatory effects in eukaryotic cells by interacting with formyl peptide receptors (fprs). it has recently been shown that activation of fprs facilitates intestinal epithelial cell restitution. we investigated whether hp(2-20) induces healing of injured gastric mucosa and assessed the mechanisms underlying any such effect. we investigated the expression of fprs in two gastric ... | 2009 | 19692643 |
| promoter hypermethylation of multiple genes in early gastric adenocarcinoma and precancerous lesions. | promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. to date, several reports on methylation of various genes in gastric cancer have been published. however, most of these studies have focused on cancer tissues or only a single gene. in this study, we determined the methylation frequency of 5 genes, including p16, runx3, mgmt, dapk, and rassf1a, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin- ... | 2009 | 19695681 |
| helicobacter pylori sequences reflect past human migrations. | the long association between the stomach bacterium helicobacter pylori and humans, in combination with its predominantly within-family transmission route and its exceptionally high dna sequence diversity, make this bacterium a reliable marker for discerning both recent and ancient human population movements. as much of the diversity in h. pylori sequences is generated by recombination and mutation on a local scale, the partitioning of h. pylori sequences from a large globally distributed data se ... | 2009 | 19696494 |
| helicobacter pylori typing as a tool for tracking human migration. | helicobacter pylori strains from different geographic areas exhibit clear phylogeographical differentiation; therefore, the genotypes of h. pylori strains can serve as markers for the migration of human populations. currently, the genotypes of two virulence factors of h. pylori, caga and vaca, and multilocus sequence typing (mlst) are widely used markers for genomic diversity within h. pylori populations. there are two types of caga: the east asian type and the western type. in addition, the rig ... | 2009 | 19702588 |
| effect of helicobacter pylori eradication on incidence of gastric cancer in human and animal models: underlying biochemical and molecular events. | gastric cancer remains one of the most common cancers worldwide. a strong association exists between helicobacter pylori infection and the risk of developing noncardia gastric cancer. h. pylori eradication by antibiotic treatment is regarded as a primary chemoprevention strategy to reduce gastric cancer incidence. | 2009 | 19702845 |
| diagnostic esophago-gastro-duodenoscopy (egd) in patients with aids-related upper gastrointestinal abnormalities. | gastrointestinal (gi) diseases are common among patients infected with human immunodeficiency virus (hiv), and may involve the entire gi tract. the aim of the article is to investigate the prevalence of various upper gastrointestinal abnormalities in patients with aids. | 2009 | 20214216 |
| helicobacter urease: niche construction at the single molecule level. | the urease of the human pathogen, helicobacter pylori, is essential for pathogenesis. the ammonia produced by the enzyme neutralizes stomach acid; thereby modifying its environment. the dodecameric enzyme complex has high affinity for its substrate, urea. we compared urease sequences and derivative 3d homology model structures from all published helicobacter genomes and an equal number of genomes belonging to strains of another enteric bacterium, escherichia coli. we found that the enzyme's arch ... | 2009 | 19920336 |
| relevance of helicobacter pylori virulence factors for vaccine development. | helicobacter pylori infection increases the risk for a wide spectrum of clinical outcomes, ranging from peptic ulcer disease to gastric cancer. however, the infection induces gastric and duodenal ulceration or gastric cancer in only a minority of infected subjects because h. pylori strains are genetically diverse and express different virulence factors. individuals infected with strains that express these virulence factors probably develop severe diseases such as gastric cancer. nevertheless, th ... | 2009 | 20464218 |
| a case of hypereosinophilic syndrome presenting with intractable gastric ulcers. | we report a rare case of hypereosinophilic syndrome (hes) presenting with intractable gastric ulcers. a 71-year-old man was admitted with epigastric pain. initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. he underwent helicobacter pylori (h pylori) eradication therapy followed by proton pump inhibitor (ppi) therapy. however, follow-up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. the proporti ... | 2009 | 20027690 |
| cross-reaction of antibody against helicobacter pylori urease b with platelet glycoprotein iiia and its significance in the pathogenesis of immune thrombocytopenic purpura. | many clinical investigations have suggested that helicobacter pylori (h. pylori) infection might be associated with immune thrombocytopenic purpura (itp), but its role in the pathogenesis of itp is unsettled. in this study, we cultured h. pylori, produced recombinant h. pylori urease (ure) b, and then prepared monoclonal antibody (moab) against ureb, 1f11, both 1f11 and moab against human platelet glycoprotein (gp) iiia, sz21, could bind to the band of gp iiia of normal platelet lysate, but not ... | 2009 | 19184277 |
| [carcinogenic mechanisms of helicobacter pylori]. | 2009 | 21089532 | |
| helicobacter pylori protein hp0175 transactivates epidermal growth factor receptor through tlr4 in gastric epithelial cells. | the pathophysiology of helicobacter pylori-associated gastroduodenal diseases, ulcerogenesis, and carcinogenesis is intimately linked to activation of epidermal growth factor receptor (egfr) and production of vascular endothelial growth factor (vegf). extracellular virulence factors, such as caga and vaca, have been proposed to regulate egfr activation and vegf production in gastric epithelial cells. we demonstrate that the h. pylori secretory protein, hp0175, by virtue of its ability to bind tl ... | 2008 | 18806258 |
| helicobacter pylori induces beta3gnt5 in human gastric cell lines, modulating expression of the saba ligand sialyl-lewis x. | chronic helicobacter pylori infection is recognized as a cause of gastric cancer. h. pylori adhesion to gastric cells is mediated by bacterial adhesins such as sialic acid-binding adhesin (saba), which binds the carbohydrate structure sialyl-lewis x. sialyl-lewis x expression in the gastric epithelium is induced during persistent h. pylori infection, suggesting that h. pylori modulates host cell glycosylation patterns for enhanced adhesion. here, we evaluate changes in the glycosylation-related ... | 2008 | 18483624 |
| [gastric lymphoma. morphological and immunohistochemical study]. | most of extranodal lymphomas are localized in gastrointestinal tract, gastric lymphoma representing more than 50% of them. the role that helicobacter pylori (h. pylori) plays in pathogenesis of gastric lymphoma has changed the therapeutic approach. | 2008 | 18677925 |
| hancornia speciosa: indications of gastroprotective, healing and anti-helicobacter pylori actions. | mangaba (hancornia speciosa gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomach ache. | 2008 | 18761076 |
| helicobacter pylori suppresses glycogen synthase kinase 3beta to promote beta-catenin activity. | the human pathogen helicobacter pylori influences cell adhesion, proliferation, and apoptosis and is involved in gastric adenocarcinoma formation. in our study we analyzed the impact of h. pylori infection on the regulation of beta-catenin, which plays a central role in both cell adhesion and tumorigenesis. infection of madin-darby canine kidney cells with h. pylori led to suppression of ser/thr phosphorylation and ubiquitin-dependent degradation of beta-catenin and to up-regulation of lymphoid ... | 2008 | 18772141 |
| evaluation of the clinical significance of homb, a novel candidate marker of helicobacter pylori strains associated with peptic ulcer disease. | homb codes for a putative helicobacter pylori outer membrane protein and has previously been associated with peptic ulcer disease (pud) in children. | 2008 | 18811585 |
| effect of helicobacter pylori eradication on oncogenes and cell proliferation. | helicobacter pylori , the main cause of chronic gastritis, is a class 1 gastric carcinogen. however, it remains unclear whether h. pylori affects molecular alterations in chronic gastritis. thus, this study was designed to investigate the effect of h. pylori eradication on the expression of human telomerase rna (htr), human telomerase reverse transcriptase (htert), c-myc and proliferation nuclear cell antigen (pcna) in h. pylori associated chronic gastritis. | 2008 | 18837738 |
| expression, purification, crystallization and preliminary x-ray analysis of an nad-dependent glyceraldehyde-3-phosphate dehydrogenase from helicobacter pylori. | helicobacter pylori is a dangerous human pathogen that resides in the upper gastrointestinal tract. little is known about its metabolism and with the onset of antibiotic resistance new treatments are required. in this study, the expression, purification, crystallization and preliminary x-ray diffraction of an nad-dependent glyceraldehyde-3-phosphate dehydrogenase from h. pylori are reported. | 2008 | 18678942 |
| [assessment of rate of hydroxyl anions production by helicobacter pylori in stomach]. | production of hydroxyl anions by tissue samples of pylorus mucous membrane obtained from 45 patients with gastric or duodenal ulcers was investigated. the production was estimated using the recently developed method based on measurement of rate of ph change in urea-containing reaction mixture. the rate of [oh-] generation as a result of h. pylori metabolism accounted on pylorus square varied from 0.4 to 1318.9 mcmol [oh-]/min, and in 90.2% of cases it did not exceed 128.1 mcmol [oh-]/min. this r ... | 2008 | 19004294 |
| the frequency of lymphocytic gastritis in baboons. | in 1985, two independent reports highlighted a novel subtype of chronic inflammation in the gastric mucosa, characterized by the intraepithelial lymphocytic infiltration (ili) both in the surface and the foveolar epithelium. the disease, subsequently called lymphocytic gastritis (lg) is a rare form of gastritis (0.8%-1.6% of cases), with unclear pathogenesis. more recently, lg was recorded in pigs and in non-human primates. | 2008 | 18396790 |
| novel protein antigen (jhp940) from the genomic plasticity region of helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages. | the plasticity region of the helicobacter pylori genome comprises strain-specific gene loci. we performed genotyping and functional biology analysis of one such locus (jhp940) that was previously found to be functionally unknown but present in gastric cancer-associated strains from many different countries. we found its geographic prevalence to be independent of caga presence and disease status. cloning, expression, and purification of jhp940 revealed a novel, approximately 36-kda protein in a b ... | 2008 | 17993522 |
| a new algorithm for cluster analysis of genomic methylation: the helicobacter pylori case. | the genomic methylation analysis is useful to type bacteria that have a high number of expressed type ii methyltransferases. methyltransferases are usually committed to restriction and modification (r-m) systems, in which the restriction endonuclease imposes high pressure on the expression of the cognate methyltransferase that hinder r-m system loss. conventional cluster methods do not reflect this tendency. an algorithm was developed for dendrogram construction reflecting the propensity for con ... | 2008 | 18086685 |
| effects of helicobacter pylori infection on gastric mucin expression. | this study was performed to determine the gastric distributions of muc5ac and muc6 depending on helicobacter pylori (h. pylori) infection, and to evaluate whether the expressions of muc5 and muc6 change in h. pylori-associated gastroduodenal diseases. in addition, muc5ac and muc6 expressional changes were investigated before and after h. pylori eradication. | 2008 | 18097286 |
| role of toll-like receptors in gastrointestinal malignancies. | mounting evidence supports the tenet that innate immune responses to luminal microbes participate in the development of gastrointestinal malignancies. the gastrointestinal tract is relatively unique in that it has evolved in the presence of diverse enteric microflora. intestinal flora is required to develop a normal adaptive immune response in the periphery. with the characterization of the innate immune system, we have begun to understand the adaptations the intestine has made to the microbiota ... | 2008 | 18176605 |
| polymorphisms in toll-like receptor genes and risk of cancer. | host genetic factors are emerging as key determinants of disease risk for many cancers. identifying candidate genes is a major challenge that has to stem from a profound understanding of the pathophysiology of the disease. the toll-like receptors are important members of the host's innate immune response and their genes have been found to be polymorphic. this genetic variation allows for a more intricate repertoire that enables the host to withstand microbial challenges. while this may be advant ... | 2008 | 18176606 |
| ccl28 is increased in human helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin a-secreting cells. | human helicobacter pylori infection gives rise to an active chronic gastritis and is a major risk factor for the development of duodenal ulcer disease and gastric adenocarcinoma. the infection is accompanied by a large accumulation of immunoglobulin a (iga)-secreting cells in the gastric mucosa, and following mucosal immunization only h. pylori-infected volunteers mounted a b-cell response in the gastric mucosa. to identify the signals for recruitment of gastric iga-secreting cells, we investiga ... | 2008 | 18426876 |
| quadruple rescue therapy for helicobacter pylori infection after two treatment failures. | a standard third-line therapy for helicobacter pylori infection is lacking, and antimicrobial sensitivity data for patients who failed eradication therapy are often unavailable in clinical practice. we therefore designed the prospective study to assess the efficacy of levofloxacin, amoxicillin, bismuth and rabeprazole quadruple therapy as a third-line treatment for h. pylori infection. | 2008 | 18435764 |
| helicobacter pylori protein response to human bile stress. | the ability of helicobacter pylori to tolerate bile is likely to be important for its colonization and survival in the gastrointestinal tract of humans. as bile can be acidified after reflux into the low ph of the human stomach, the inhibitory effect of fresh human bile with normal appearance on h. pylori before and after acidification was tested first. the results showed that acidification of bile attenuated its inhibitory activity towards h. pylori. next, the protein profiles of h. pylori unde ... | 2008 | 18201979 |
| long-term follow-up of gastrectomized patients with mucosa-associated lymphoid tissue lymphoma: need for a revisit of surgical treatment. | gastric mucosa-associated lymphoid tissue (malt) lymphoma is characterized by multifocality of the tumors, which often scatter over the mucosa of the stomach and adjacent upper gastrointestinal tract, and is therefore theoretically not curable by surgical resection. | 2008 | 18216531 |
| severe hypoglycemia from clarithromycin-repaglinide drug interaction. | many drugs have been reported to interact with repaglinide in patients with type 2 diabetes mellitus, resulting in hypoglycemia. however, to our knowledge, an interaction between clarithromycin and repaglinide in these patients has not been previously reported. we describe an 80-year-old man with end-stage renal disease and well-controlled type 2 diabetes (hemoglobin a1c < 7%) who was hospitalized for treatment of severe hypoglycemia. he had been receiving repaglinide 0.5 mg 3 times/day for the ... | 2008 | 18447665 |
| chronic active gastritis in x-linked lymphoproliferative disease. | gastric lesions in primary constitutive immune deficiencies include multifocal atrophic gastritis, erosive pangastritis, and a pattern of gastric lesions reminiscent of graft-versus-host disease. we describe the genetic anomalies in 2 monozygotic twins with an x-linked lymphoproliferative disease (xlp; mim 308240), a rare familial setting of high susceptibility to epstein-barr virus (ebv). since early childhood, both twin brothers exhibited a severe chronic active atrophic pangastritis. a germli ... | 2008 | 18223336 |
| probiotics, prebiotics, and synbiotics. | according to the german definition, probiotics are defined viable microorganisms, sufficient amounts of which reach the intestine in an active state and thus exert positive health effects. numerous probiotic microorganisms (e.g. lactobacillus rhamnosus gg, l. reuteri, bifidobacteria and certain strains of l. casei or the l. acidophilus-group) are used in probiotic food, particularly fermented milk products, or have been investigated--as well as escherichia coli strain nissle 1917, certain entero ... | 2008 | 18461293 |
| chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: a fluorescent in situ hybridization study using a tissue microarray approach. | extranodal marginal zone b-cell lymphomas (mucosa-associated lymphoid tissue [malt] lymphomas) of the gastrointestinal tract have been known to have characteristic chromosomal aberrations including trisomies of chromosomes 3, 12, and 18. however, knowledge of the clinical significance of cytogenetic changes in malt lymphomas is still limited. in the present study, the frequency of the numeric and structural aberrations of the chromosomes 1, 3, 12, 18 and x and of the malt1 gene as well as their ... | 2008 | 18234275 |
| h pylori (caga) and epstein-barr virus infection in gastric carcinomas: correlation with p53 mutation and c-myc, bcl-2 and bax expression. | to investigate the interrelationship between h pylori and epstein-barr virus (ebv) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-myc, bcl-2 and bax expression. | 2008 | 18240345 |
| breast cancer and microbial cancer incidence in female populations around the world: a surprising hyperbolic association. | current literature on cancer epidemiology typically discusses etiology of cancer by cancer type. risks of different cancer types are, however, correlated at population level and may provide etiological clues. we showed previously an unexpected very high positive correlation between breast cancer (bc) and young-adult hodgkin disease incidence rates. in a population-based case-control study of bc, older ages at the first epstein-barr virus exposure, indicated by older ages at onset of infectious m ... | 2008 | 18537160 |
| the effects of physical and psychological stress on the gastro-intestinal tract: lessons from animal models. | physical and psychological stresses are widely accepted as triggers and / or modifiers of the clinical course of diverse gastrointestinal disorders such as peptic ulcer, irritable bowel syndrome or inflammatory bowel disease. growing experimental evidence from a variety of models such as immobilization, thermal injury or early maternal deprivation in laboratory animals uniformly supports the ability of stress to induce the development of gastric ulcers, altered gastrointestinal motility and ion ... | 2008 | 18537637 |
| loss of imprinting of igf2 and h19, loss of heterozygosity of igf2r and ctcf, and helicobacter pylori infection in laryngeal squamous cell carcinoma. | imprinting analyses of igf2 and h19, loss of heterozygosity (loh) analyses of igf2r and ctcf and helicobacter pylori detection, were performed on 35 human laryngeal squamous cell carcinomas (lscc). forty-six percent of the tumors were heterozygous for igf2, and 54% were informative for the h19. biallelic expression of igf2 was observed in 33% (5 out of 15) of the tumors and in 27% (4 out of 15) of adjacent non-tumorous laryngeal tissues. h19 loss of imprinting (loi) was observed in 24% (4 out of ... | 2008 | 18604514 |
| the effects of cyclooxygenase2-prostaglandine2 pathway on helicobacter pylori-induced urokinase-type plasminogen activator system in the gastric cancer cells. | urokinase-type plasminogen activator (upa) and its receptor (upar) play an important role in the destruction of the extracellular matrix and basement membrane. the induction of upa and upar in the gastric cancer cells with h. pylori has been demonstrated previously. the involvement of cox-2-pge2 pathway in the upa system (upa and upar) expression is unclear. | 2008 | 18466392 |
| aetiology of cancer in asia. | cancer has become the leading cause of death in many asian countries. there is an increasing trend in breast, prostate and colon cancers, which are considered as typical of economically developed countries. although breast and prostate cancer rates are still lower than in western countries, they are particularly rapidly increasing. in this paper, we review recently published literature to identify important etiologic factors affecting the cancer risk in asian populations. infectious agents such ... | 2008 | 18990005 |
| infectious agents and colorectal cancer: a review of helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus. | based on the high volume of bacteria and viruses that the intestine is exposed to and the importance of infectious agents in some gastrointestinal and anogenital cancers, it is not surprising the many studies have evaluated the association between colorectal cancer and infectious agents. this review highlights investigations of four agents in relation to colorectal cancer. helicobacter pylori, streptococcus bovis, jc virus, and human papillomavirus have all been evaluated as possible etiologic a ... | 2008 | 18990738 |
| [decrease of the prevalence of helicobacter pylori infection in the czech republic]. | helicobacter pylori (hp) is the most common chronic bacterial infection in humans. hp has been demonstrated worldwide and in individuals of all ages. the overall prevalence of hp infection has fallen dramatically in the czech republic over recent 15 years (from 70% in 1993 to 35% in 2006). this decrease can be explained mostly by the relatively favourable and improving socioeconomic conditions after the fall of communist regime. however, it is necessary to consider also the fundamental determina ... | 2008 | 18630179 |
| causality and gastrointestinal infections: koch, hill, and crohn's. | the gastrointestinal tract contains a complex mix of microorganisms. therefore, the finding of a particular microbe in the gastrointestinal tract or stools of a patient with intestinal disease does not necessarily indicate that the clinical state resulted from the presence of this organism. for this reason, extending from epidemiological association to causality is particularly challenging for gastrointestinal diseases. most established agents of acute bacterial gastroenteritis (eg, escherichia ... | 2008 | 18992408 |
| helicobacter pylori activates gastric epithelial cells to produce interleukin-8 via protease-activated receptor 2. | recently, it has been shown that serine proteases derived from microorganisms stimulate epithelial cells to produce inflammatory mediators through protease-activated receptor (par). we investigated the involvement of par2 in the interleukin (il)-8 production by helicobacter pylori-infected gastric epithelial cells. | 2008 | 18196899 |
| dynamic colonization of helicobacter pylori in human gastric mucosa. | to investigate the dynamic behaviour of helicobacter pylori in the colonization of the human gastric mucosa in patients previously treated for h. pylori infection. | 2008 | 17918004 |
| discovering differential protein expression caused by caga-induced erk pathway activation in ags cells using the seldi-proteinchip platform. | to identify the protein expression differences related to the caga-induced erk pathway activation in ags cells. | 2008 | 18203287 |
| il-4 -588c>t polymorphism and il-4 receptor alpha [ex5+14a>g; ex11+828a>g] haplotype concur in selecting h. pylori caga subtype infections. | the th2 cytokine il-4 might limit h. pylori associated gastric inflammation and favour h. pylori clearance. the aim of the study was to verify whether il-4 -588c>t snp, or two snps of the gene coding the alpha chain of il-4 receptor (il-4ra ex5+14a>g, il-4ra ex11+828a>g) considered singly or as haplotypes, are correlated with h. pylori virulence genes or h. pylori associated diseases. | 2008 | 18179773 |
| toll-like receptor 2 (tlr) -196 to 174del polymorphism in gastro-duodenal diseases in japanese population. | toll-like receptors (tlrs) play important roles in the signaling of many pathogen-related molecules and endogenous proteins associated with immune activation. -196 to -174del polymorphism affects the tlr2 gene and alters its promoter activity. we investigated the influence of tlr2 -196 to -174del polymorphism on the risk of gastro-duodenal diseases, on the severity of helicobacter pylori-induced gastritis in a japanese population. the study was performed on 309 patients with abdominal discomfort ... | 2008 | 17934843 |
| periodontitis may increase the risk of peripheral arterial disease. | the aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (pad). | 2008 | 17964192 |
| enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from helicobacter pylori. | cystathionine gamma-synthase (cgs) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human. in this report, we identified a new metb gene from helicobacter pylori strain ss1, and the recombinant h. pylori cystathionine gamma-synthase (hpcgs) was successfully cloned, expressed and purified in escherichia coli system. enzymatic study of hpcgs indicated that the k(m) and k(cat)/k(m) values against the s ... | 2008 | 17981822 |
| pseudomyxoma peritonei: is disease progression related to microbial agents? a study of bacteria, muc2 and muc5ac expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. | pseudomyxoma peritonei (pmp) is characterized by peritoneal tumors arising from a perforated appendiceal adenoma or adenocarcinoma, but associated entry of enteric bacteria in the peritoneum has not been considered as a cofactor. because gram-negative organisms can upregulate muc2 mucin gene expression, we determined whether bacteria were detectable in pmp tissues. | 2008 | 18299935 |
| vitamin c supplementation does not protect l-gulono-gamma-lactone oxidase-deficient mice from helicobacter pylori-induced gastritis and gastric premalignancy. | in human studies, low vitamin c intake has been associated with more severe helicobacter pylori gastritis and a higher incidence of gastric cancer. however, vitamin c supplementation has not been definitively shown to protect against gastric cancer. using vitamin c-deficient b6.129p2-gulo(tm1umc/mmcd) (gulo(-/-)) mice lacking l-gulono-gamma-lactone oxidase, we compared gastric lesions and th1 immune responses in h. pylori-infected gulo(-/-) mice supplemented with low (33 mg/l) or high (3,300 mg/ ... | 2008 | 17990318 |
| transgenic expression of helicobacter pylori caga induces gastrointestinal and hematopoietic neoplasms in mouse. | infection with caga-positive helicobacter pylori is associated with gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (malt) lymphoma of b cell origin. the caga-encoded caga protein is delivered into gastric epithelial cells via the bacterial type iv secretion system and, upon tyrosine phosphorylation by src family kinases, specifically binds to and aberrantly activates shp-2 tyrosine phosphatase, a bona fide oncoprotein in human malignancies. caga also elicits junctional and ... | 2008 | 18192401 |
| autoantibodies against appetite-regulating peptide hormones and neuropeptides: putative modulation by gut microflora. | peptide hormones synthesized in gastrointestinal and adipose tissues in addition to neuropeptides regulate appetite and body weight. previously, autoantibodies directed against melanocortin peptides were found in patients with eating disorders; however, it remains unknown whether autoantibodies directed against other appetite-regulating peptides are present in human sera and whether their levels are influenced by gut-related antigens. | 2008 | 18262391 |
| yeast of the oral cavity is the reservoir of heliobacter pylori. | frequent occurrence of helicobacter pylori in the human gastrointestinal tract and its persistence due to unsuccessful antimicrobial therapy might be related to a stage in the life cycle of h. pylori in which the bacterium establishes itself as an intracellular symbiont in yeast. in this study, occurrence of non-culturable h. pylori in the oral yeast was assessed by targeting vacuolating cytotoxin a (vaca s1s2) and ureab genes in the total dnas of yeasts. | 2008 | 18266659 |
| difference of p53aip1 mrna expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with helicobacter pylori. | to examine the significance of alteration of p53-regulated apoptosis-induced protein 1 (p53aip1) expression in gastric carcinogenesis in patients with helicobacter pylori infection. | 2008 | 18277906 |
| association of helicobacter pylori and epstein-barr virus with gastric cancer and peptic ulcer disease. | helicobacter pylori and epstein-barr virus (ebv) infections are common world-wide. though h. pylori infection is a major factor in gastroduodenal diseases, its role in association with ebv infection is unknown. we prospectively studied the association of h. pylori and ebv in patients with gastric cancer (gc) and peptic ulcer disease (pud). | 2008 | 18569983 |
| the role of infectious agents in the etiology of ocular adnexal neoplasia. | given the fact that infectious agents contribute to around 18% of human cancers worldwide, it would seem prudent to explore their role in neoplasms of the ocular adnexa: primary malignancies of the conjunctiva, lacrimal glands, eyelids, and orbit. by elucidating the mechanisms by which infectious agents contribute to oncogenesis, the management, treatment, and prevention of these neoplasms may one day parallel what is already in place for cancers such as cervical cancer, hepatocellular carcinoma ... | 2008 | 18572051 |
| effects of different helicobacter pylori culture filtrates on growth of gastric epithelial cells. | to study the effects of different helicobacter pylori (h pylori) culture filtrates on growth of gastric epithelial cells. | 2008 | 18595143 |
| identification of proteins related to nickel homeostasis in helicobater pylori by immobilized metal affinity chromatography and two-dimensional gel electrophoresis. | helicobacter pylori (h. pylori) is a widespread human pathogen causing peptic ulcers and chronic gastritis. maintaining nickel homeostasis is crucial for the establishment of h. pylori infection in humans. we used immobilized-nickel affinity chromatography to isolate ni-related proteins from h. pylori cell extracts. two-dimensional gel electrophoresis and mass spectrometry were employed to separate and identify twenty two ni-interacting proteins in h. pylori. these ni-interacting proteins can be ... | 2008 | 18288244 |
| effect of eradication of helicobacter pylori on the histology and cellular phenotype of gastric intestinal metaplasia. | eradication of helicobacter pylori appears to reduce gastric cancer incidence. we examined the effect of successful h pylori therapy on histology, phenotype of gastric intestinal metaplasia (gim) (complete vs incomplete), and expression of several biomarkers related to carcinogenesis. | 2008 | 18321787 |
| helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. | we have characterized the adaptations of helicobacter pylori to a rarely captured event in the evolution of its impact on host biology-the transition from chronic atrophic gastritis (chag) to gastric adenocarcinoma-and defined the impact of these adaptations on an intriguing but poorly characterized interaction between this bacterium and gastric epithelial stem cells. bacterial isolates were obtained from a single human host colonized with a single dominant strain before and after his progressio ... | 2008 | 18332421 |
| chronic autoimmune thyroiditis (hashimoto's thyroiditis) in patients with malt lymphoma. | autoimmune diseases have been implicated in the genesis of malt lymphoma of various localizations. the development of thyroidal malt lymphoma has been described as an adverse event in patients suffering from long-standing chronic autoimmune thyroiditis (cat, hashimoto's thyroiditis). the percentage and possible association between cat and extrathyroidal malt lymphoma, however, have not been assessed so far. | 2008 | 18334510 |
| significantly elevated helicobacter pylori density and different genotype distribution in erosions as compared with normal gastric biopsy specimen detected by quantitative real-time pcr. | determination of the local densities of helicobacter pylori and its genotypic variations in gastric biopsy specimens by using novel real-time pcr-based methods could support the precise diagnosis and understanding of h. pylori infections. | 2008 | 18334874 |
| the alpha and beta classes carbonic anhydrases from helicobacter pylori as novel drug targets. | helicobacter pylori (h. pylori) successfully resides in the human stomach in highly acidic conditions, causing a variety of gastroduodenal lesions, including gastric ulcer, gastric cancer and malt lymphoma. for acid acclimation of h. pylori, two types of enzymes, urease and carbonic anhydrase (ca), play a central role. they cooperatively function to maintain neutral ph in the bacterial cytoplasm and periplasm. the genome project of h. pylori identified two different classes of ca with different ... | 2008 | 18336307 |
| cdh1 gene polymorphisms, smoking, helicobacter pylori infection and the risk of gastric cancer in the european prospective investigation into cancer and nutrition (epic-eurgast). | despite declining incidence rates, gastric cancer (gc) is a major cause of death worldwide. e-cadherin is an adhesion molecule that is thought to be involved in gc. germline mutations in the e-cadherin gene (cdh1) have been identified in hereditary diffuse gc. also, a promoter polymorphism at position -160 c/a has been suggested to lead to transcriptional down regulation and has been shown to affect gc risk in some studies. however, very little information exists on the gc risk association of ot ... | 2008 | 18342503 |
| the distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients. | this study used monoclonal antibody specific for 4-hydroxynonenal (hne)-histidine to evaluate immunohistochemical distribution of hne-protein adducts in gastric mucosa biopsies of 52 peptic ulcer patients (all positive for h. pylori) and of 20 healthy volunteers (eight positive and 12 negative for h. pylori). hne-modified proteins were present in glandular epithelium in all subjects, both patients with duodenal peptic ulcer and healthy subjects. hence, the presence of hne did not appear to be re ... | 2008 | 18344114 |