Publications

preliminary clinical pharmacological investigations of tylosin and tiamulin in chickens.	the minimal inhibitory concentrations (mic) of tiamulin and tylosin for mycoplasma, gram-positive, and gram-negative micro-organisms isolated from chickens were determinated by the agar dilution method. median mic values for tiamulin against mycoplasma gallisepticum (0.05 microgram/ml) and mycoplasma synoviae (0.10 microgram/ml) were 2 to 4 times lower than the corresponding values for tylosin. tiamulin was also slightly more effective in vitro in inhibiting escherichia coli, pasteurella multoci ...	1980	7444918
virulence and morphology of pasteurella multocida of avian origin.	the virulence of 100, 54 and nine avian isolates of pasteurella multocida for mice, chickens and turkey poults respectively was assessed and rated on a scale from 0 to 5. cellular and colonial morphology of the bacteria was examined after mouse passage. there was evidence of a considerable range in the virulence of the isolates for the test species, but no correlation between cellular or colonial morphology and virulence was detected. the results obtained are discussed in relation to general epi ...	1980	7445378
chemotaxis of fowl monocytes to pasteurella multocida and associated antigens.	the interaction of monocytes and serum from pasteurella multocida-immunized and non-immunized turkeys and chickens was studied for their chemotactic activity to lipopolysaccharide, free endotoxin, and p. multocida whole cells. chemotactic factors were released from the interaction between either normal sera or antisera and the bacterial antigens. heating of the sera affected their ability to interact and release chemotaxins. heated normal sera were ineffective and heated antisera were less effec ...	1980	7447836
preliminary clinical pharmacological investigations of tylosin and tiamulin in chickens.	summary the minimal inhibitory concentrations (m1c) of tiamulin and tylosin for mycoplasma. gram-positive, and gram-negative micro-organisms isolated from chickens were determinated by the agar dilution method. median m1c values for tiamulin against mycoplasma gallisepticum (0.05 µg/ml) and mycoplasma synoviae (0.10 µg/ml) were 2 to 4 times lower than the corresponding values for tylosin. tiamulin was also slightly more effective in vitro in inhibiting escherichia coli, pasteurella multocida, ...	1980	22039981
serotyping of pasteurella multocida isolants from poultry.	a total of 607 pasteurella multocida strains were isolated in israel from turkeys, geese, and chickens. serotyping was carried out by the gel-diffusion precipitin test. the antigens were heat-stable saline extracts of the organisms, and the diagnostic sera were produced in chickens using formalinized bacterins. among 31 serotypes containing one to five antigenic factors, serotypes 1 and 3 accounted for 58.1%, 80.8%, and 88.9% isolants from turkeys, geese, and chickens, respectively. on the basis ...	1979	118742
vaccination of chickens through the drinking water with a live, pasteurella multocida, vaccine.	broiler-type chickens were vaccinated orally at several ages with various dilutions of the clemson university (cu) strain of pasteurella multocida vaccine and then challenged orally with virulent strain p-1059 or strain x-73 of p. multocida to determine the degree of protection produced by vaccination. when vaccinated at 8 and 12 weeks of age for 2 consecutive days with a 1:133 dilution of the vaccine and then challenged at 17 and 19 weeks of age with strain x-73 and p-1059 p. multocida, respect ...	1979	471883
observations on avian pasteurellosis in britain.	an investigation into the extent and significance of pasteurella multocida infections of birds and poultry in britain during a three year period (1974--1977) was undertaken. this was achieved by means of postal questionnaires, coupled with the biochemical and serological examination of bacterial isolates from 91 outbreaks in poultry and from nine cases in other avian species.	1979	473564
pasteurella multocida as a cause of arthrosynovitis and tenosynovitis in broiler chickens.		1979	475684
observations on the differences concerning the immunizing ability of pasteurella multocida of avian origin.		1979	546373
attenutated live fowl cholera vaccine. iii. laboratory and field vaccination trials in turkeys and chickens.	administered via the drinking water, m-3-g, an attenuated strain of pasteurella multocida of serotype 1, was found to immunize turkeys and chickens against fowl cholera. immunity was tested by challenging birds intramuscularly, by palatine cleft swab, or orally after 3 vaccinations. no reactions to vaccination were noted in 390 turkeys in 12 laboratory trials, nor in 20,245 vaccinated in field trials. chickens showed no vaccination reactions, and immunity was elicited by challenge in a laborator ...	1979	546411
vaccination immunity to selected diseases in chickens fed the androgen analog mibolerone.	chickens fed the androgen analog mibolerone during the first 7 weeks of life regress their bursa of fabricius but can be properly immunized by vaccination against avian pathogens of major economic importance such as newcastle disease virus, infectious laryngotracheitis virus, avian encephalomyelitis virus, infectious bronchitis virus, fowl pox virus, marek's disease virus, and pasteurella multocida, the pathogen causing fowl cholera. these findings on immunocompetence to infectious agents are im ...	1978	209430
comparison of effects of dietary t-2 toxin on growth, immunogenic organs, antibody formation, and pathologic changes in turkeys and chickens.	the effect of t-2 toxin (trichothecene mycotoxin) consumption on broad-breasted white turkey poults and white leghorn chicks was studied. groups of ten 8-day-old poults were fed rations containing t-2 at 10 ppm, 2ppm, or 0 ppm (controls) for a period of 4 weeks; a 4th group (inanition control) was fed control rations equal to the amount consumed by the group fed rations containing t-2 at 10 ppm during the previous 24 hours. a similar experimental design was used to study the effect of the toxin ...	1978	362995
response of young chickens and turkeys to virulent and avirulent pasteurella multocida administered by various routes.	groups of 20 young chickens and turkeys obtained from commercial flocks and placed in pens with pine shavings over concrete floors or from the hatchery and grown on wire, were exposed to avirulent pasteurella multocida serotype 3,4 cross or virulent p. multocida serotype 3 by drinking water, ocular, subcutaneous, intracutaneous, or palatine cleft routes. a secondary exposure to virulent p. multocida serotype 1 by the palatine cleft route was given 14 days later, except that birds exposed by pala ...	1978	646754
effect of bursectomy and thymectomy on pasteurella multocida infection in chickens.	the effects of various treatments on the immune response of chickens to vaccine prepared from pasteurella multocida strain p1059 were investigated. the treatments, given on or before the day of hatching, consisted of surgical bursectomy (sb), hormonal bursectomy (hb), surgical thymectomy (st) and x-irradiation (x). in chickens subjected to sb, sbx or hb before vaccination, the production of agglutinin and immunoglobulin was impaired, but the production of resistance against challenge was not. in ...	1978	682178
pasteurella multocida infection of broiler chickens.		1978	716191
subcutaneous vaccination of chickens with a live, avirulent pasteurella multocida, vaccine.	the immunogenic responses to various routes of vaccination of broiler-type chickens to the clemson university strain of pasteurella multocida were evaluated. broilers were vaccinated at 9 or 10 weeks of age using the oral (drinking water), palatine cleft, ocular, or subcutaneous injection routes. all birds were challenged at 11 or 12 weeks of age with virulent x-73 strain of p. multocida by the palatine cleft method. the degree of efficacy of the various vaccination routes differed among three e ...	1978	751031
mechanisms of acquired resistance to pasteurella multocida infection: a review.	pasteurella multocida is an animal parasite of considerable economic and veterinary importance. the organism produces both capsular polysaccharide and somatic (lipopolysaccharide) antigens used to serotype the organisms. correlations exist between antigenic structure, host susceptibility and strain virulence. the host response seems to be predominantly polymorphonuclear in nature, with little evidence of a mononuclear component in the host response to infection. in the absence of specific opsoni ...	1977	832473
immunogenic activity of a ribosomal fraction obtained from pasteurella multocida.	the cells of p. multocida strain p-1059 were destroyed with the french pressure cell; the ribosomal fraction proven to be homogeneous by analytical ultracentrifugation was obtained from the product by centrifugal fractionation, zonal electrophoresis, and sephadex g-200 gel filtration. the ribosomal fraction exhibited intense protective antigenicity in mice and chickens, but the lipopolysaccharide (endotoxin) and the other bacterial cell fraction obtained in this experiment did not. sodium deoxyc ...	1977	832895
fowl cholera: induction of cross-protection in turkeys with bacterins prepared from host-passaged pasteurella multocida.	modified fowl cholera bacterins prepared by inoculating agar medium with infected liver tissue from birds which died of acute fowl cholera induced 70% cross-protection in turkeys, i.e., protection against a different immunologic type of pasteurella multocida. standard bacterins prepared from cultures which had been lyophilized and stored showed variable cross-protection (0--40%). repeated subculturing of the standard inoculum on agar reduced cross-protection. the protection with either the modif ...	1977	843303
fowl cholera: immunization of chickens with potassium thiocyanate (kscn) extract of pasteurella multocida serotype 3.	potassium thiocyanate (kscn) extract of pasteurella multocida, serotype 3, was found to be immunogenic against a challenge infection of homologous as well as one heterologous strain tested (serotype 1). ouchterlony's gel-diffusion analysis revealed the presence of two components in the kscn-extracts of both serotypes 3 and 1, which were antigenically identical.	1977	606217
studies on pasteurella gallinarum.	in two outbreaks of disease in chickens associated with pasteurella gallinarum infection swollen and inflamed wattles were symptoms. a bacteriological study was carried out of 42 p. gallinarum strains isolated from the two outbreaks and from sporadic cases in fowls. serotyping by the gel diffusion precipitin test indicated that all five strains from one outbreak and 82% of isolants from 22 sporadic cases belonged to one serotype, antigenically unrelated to pasteurella multocida. all four isolant ...	1977	18770350
[enzootic dermonecrosis in chickens].	an enzootic of necrotic dermatosis in hen layers was described. the changes consisted in that they had constant localization and demarkated sites on the skin between the back and the neck. the disease was observed on a farm for 5000 layers in the course of two consecutive years. all birds contracted the disease and in the first year they recovered the 10 months; in second year they recovered for three months. each bird showed symptoms for 3 weeks. the skin lesions resulted in cicatrization. the ...	1976	951928
immunogenic and toxic properties of a purified lipopolysaccharide-protein complex from pasteurella multocida.	an immunogenic fraction from pasteurella multocida was found to consist chiefly of a high-molecular-weight protein-polysaccharide complex containing 25 to 27% protein and 10.7% carbohydrate. the starting material was obtained by differential centrifugation at 105,000 x g of saline extract of p. multocida cells and further purified by gel filtration on sepharose 2b. three peaks were usually obtained after gel filtraion.pharose 2b. three peaks were usually obtained after gel filtration. the compon ...	1976	825472
properties of free endotoxin from pasteurella multocida.	free endotoxin (fet) from virulent encapsulated pasteurella multocida or from an avirulent nonencapsulated mutant is capable of inducing active immunity, but the lipopolysaccharide (lps) moiety of the endotoxin is not. these results suggest that a protein of p multocida is involved in the stimulation of active immunity. the serologic specificity of the fet is associated with the lps moiety, which is related to a heat extracted antigen that is used for serotyping p multocida. the fet is capable o ...	1975	1092224
diverse effects of bursectomy on humoral immune responses in the chicken.	chickens bursectomized hormonally or surgically at various ages in embryonic to postembryonic lives were immunized with a mixture of antigens, and the antibodies produced titrated. immune responses to salmonella pullorum (sp), brucella abortus (ba). staphylococcus aureus (staph) and ovalbumin (oa) were more markedly suppressed by the bursal deprivation than those to heterogenous erythrocytes, viruses and such bacteria as pasteurella multocida (pm) and escherichia coli b. the immune response to b ...	1975	1187514
a comparison of commercial mycoplasma gallisepticum antigens in the rapid serum agglutination test.	twenty-three chickens, aged 9 weeks, were housed in contact with a similar group of chickens which were infected with m. gallisepticum. the onset and development of the serum agglutinin responses which were detected by 3 commercial antigens using rapid serum agglutination tests up to 20 weeks of age, differed greatly both between the infected and in-contact groups and, within the latter group, between the antigens. few reactions, which were weak and transient, were detected in 2 similar groups o ...	1975	1222006
fowl cholera; cross-protective turkey antisera and igg antibodies induced with pasteurella multocida-infected tissue bacterins.	turkey antisera induced with formolized pasteurella multocida-infected tissues (t antisera) passively cross-immunized 48 of 55 chickens against a challenge dose of p. multocida organisms, from which 0 of 15 controls survived. however, turkey antisera induced with formalin-killed, agar-cultured p. multocida cells (a antisera) passively cross-immunized only 4 of 30 chickens. cross-immunity refers to protection against a different immunologic type of p. multocida. quantitative precipitin reactions ...	1975	804994
[changes in carbohydrate metabolism in hens experimentally infected with pasteurella multocida kokoshki].	studied were the concentration of blood sugar, the activity of glucose-6-phosphatase and glucose-6-phosphatedehydrogenase, and the level of glycogen in the liver of p. multocida infected chickens. an abrupt decrease of the liver glycogen was found as well as a negligible rise of the blood sugar. the activity of glucose-6-phosphatase remained unchanged, and that of glucose-6-dehydrogenase was twice as high. it is concluded that the intense exhaustion of liver glycogen is in connection with the ac ...	1975	174282
fowl cholera bacterins: host-specific cross-immunity induced in turkeys with pasteurella multocida propagated in embryonating turkey eggs.		1974	4133381
serotype results of pasteurella multocida isolated from poultry in south carolina.		1974	4828583
serological and biochemical characteristics of pasteurella multocida from free-flying birds and poultry.		1972	4628015
observations on the prevalence of avian pasteurella multocida serotypes.		1970	5456432
fowl cholera: active immunity induced in chickens and turkeys by oral administration of killed pasteurella multocida.		1968	4966901
survival of pasteurella multocida in soil, water, carcasses, and in the mouths of various birds and mammals.		1968	5258003
studies on the pathogenicity of pasteurella multocida for mice and chickens on the basis of o-groups.		1964	14140882
a comparison of virulence for mice and chickens of different colonial variants of the three serological types of pasteurella multocida.		1956	13283245
studies on a pasteurella multocida chicken embryo vaccine. ii. type-specific nature of immunity elicited by a monovalent pasteurella multocida vaccine.		1951	14878125
studies on a pasteurella multocida chicken embryo vaccine. i. the comparative immunizing value of broth bacterins and a chicken embryo vaccine in mice.		1950	15425748