Publications

effect of vasectomy on thyroid function.	long-evans rats vasectomized unilaterally or bilaterally at 2 months of age showed marked reductions in weight of testes, seminal vesicles and prostate glands 2 and 12 months post-vasectomy. thyroid weight, thyroid 131i uptake, serum pb131i, circulating levels of serum t4 and chromatographic analysis of thyroid hydrolysates revealed no alterations due to vasectomy. these findings indicate that vasectomy, unilateral or bilateral, and whether of 2 or 12 months duration, did not exert an effect on ...	1978	569891
effects of experimental hypothyroidism on skeletal muscle metabolism in the rat.	hind-limb perfusion was used to study the effect of thyroidectomy on some metabolic parameters in the skeletal muscle of the rat. a week after thyroidectomy obtained by one dose of 3/4 mci 131i, neither t4 nor t3 was detected in the blood. lactate production and glycerol production were already decreased a week after the treatment and reached a base level at two weeks. at that time, the oxygen consumption was significantly lower (70% of initial level) than in the control animals and decreased fu ...	1978	579526
correlation between per cent discharge of thiocyanate test and thyroid functions in patients with hashimoto's disease.	the thiocyanate test was carried out in 18 patients with hashimoto's disease. thiocyanate was given orally several hours after the administration of tracer doses of 131i when the thyroid counts seemed to have reached a plateau. the per cent discharge of thiocyanate test was significantly higher in the groups with lower level of t4 (less than 5.5 microgram/100 ml), rsh (less than 25.5%) and bmr (less than +2.5%), and higher levels of tsh (greater than 10.0 muu/ml). a chi-square (chi2) test with y ...	1978	579536
opposite variations in serum t3 and reverse t3 during propylthiouracil treatment of thyrotoxicosis.	blood samples for determination of serum total and free reverse triiodothyronine (rt3), triiodothyronine (t3) and thyroxine (t4) were obtained daily in 6 previously untreated thyrotoxic patients during periods of propylthiourazil (ptu) (600 mg per day) or methimazol (mmi) (45 mg per day) administration. ptu induced about 60 per cent increase in both total and free serum rt3. this was accompanied by a rapid decrease in serum t3 and a more gradual decline in serum t4. mmi administration to untreat ...	1978	579537
iodoamino acid composition of poorly iodinated human thyroglobulin fractionated by isopycnic centrifugation.	the distribution of iodotyrosines and iodothyroinines has been studied in poorly iodinated 19 s thyroglobulins isolated by sucrose gradient centrifugation from five human thyroid tissue. the 19 s thyroglobulins have been fractionated by isopycnic centrifugation and 34.5% rubidium chloride gradient. the distribution of iodoamino acids depends on the total iodine content of each fraction. the variations in mit) and dit residues with increasing levels of iodination are not identical, the elevation ...	1978	580134
inappropriate triiodothyronine (t3) and thyroxine (t4) radioimmunoassay levels secondary to circulating thyroid hormone autoantibodies.		1978	580230
correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with graves' disease and subacute thyroiditis.	serum thyroglobulin (tg), triiodothyronine (t3), and thyroxine (t4) concentrations were measured in sera from selected patients with hyperthyroidism due to graves' disease and with subacute thyroiditis. in agreement with previous reports, the concentration of serum tg was elevated in untreated hyperthyroidism due to graves' disease, being 132 +/- 124 ng/ml (mean +/- sd) as opposed to 11 +/- 6.4 ng/ml in normal subjects. during treatment of hyperthyroidism with antithyroid drugs with or without i ...	1978	580305
chemical determination of iodinated compounds in human thyroid.	as a tool with which to detect iodinated compounds in human thyroid specimens, we have reevaluated a nonincineration technique which has so far been employed in the determination of thyroxine-iodine in peripheral blood. the catalytic action of iodoamino acids in the ce-as reaction was enhanced by a small amount of cl2. on the contrary, a large amount of cl2 inhibited the reaction unexpectedly. among iodide, iodotyrosine and iodothyronine, iodide was the most effective catalyst in the ce-as react ...	1978	580417
thyroid hormone formation in ectopic thyroid gland. a case study.	several steps of thyroid hormogenesis were studied on a subhyoid ectopic thyroid tissue in a case of compensated hypothyroidism with simultaneous sublingual and subhyoid ectopic thyroid. the patient, a 19-year-old girl, had normal values for serum t4, t3u and t3, and an elevated serum tsh level. the thyroidal 131i uptake was elevated both at 3 h and 24 h after oral 131i intake. no significant discharge of radioiodine was observed after perchlorate load. on the thyroid biopsy specimen, peroxidase ...	1978	580519
thyroxine: studies concerning its intrinsic physiological activity.	the importance of the monodeiodination of t4 to t3 in the physiological action of t4 was explored by assessing the role of t4 in maintaining prophylthiouracil (ptu)-treated rats during exposure to 4 degrees c. (ptu inhibits both thyroid hormone biosynthesis and t4 to t3 conversion in peripheral tissues.) firstly, the effects of cold exposure on the metabolism of t4 in control and ptu-treated rats equilibrated with [125i]t4 (2 microgram/100 g b. w./day) were determined. ptu was administered in th ...	1978	580539
the relative distribution of thyroxine, triiodothyronine and 3,3',5'-(reverse)-triiodothyronine in various fractions of thyroglobulin.	thyroglobulin fractions rich and poor in new thyroglobulin were separated by means of deae-cellulose chromatography of dog thyroid extracts and by zonal ultracentrifugation in a sucrose gradient of guinea pig thyroid extract incubated at low temperature. the distrubtion of thyroxine, triiodothyronine and 3,3',5'-(reverse)-triidothyronine in hydrolysates of the different fractions was estimated by radioimmunoassays. following deae-cellulose chromatography there was a small but statistically signi ...	1978	580831
thyroid hormone uptake and t4 derived t3 formation in different skeletal muscle types of normal and hyperthyroid rats.		1978	580832
serum levels of tsh, t3, rt3, t4 and t3-resin uptake in surgical trauma.	changes in thyroid hormone metabolism induced by surgical trauma were studied by determination of tsh, t3, rt3, t4 and t3-resin uptake before, during and after mastectomy in 20 women and cholecystectomy in 10 women. pronounced and reciprocal changes, explained by altered peripheral t4 metabolism were found concerning t3 and rt3. the decreased t3 and increased rt3-levels approached or exceeded the limits of the reference range on the first post-operative day. a significant increase in t3-resin up ...	1978	581019
relationship between peroxidase activity and serum tsh, t4 and t3 levels in rats in the course of iodine deficiency.		1978	581021
the relationship between levels of thyroid stimulating hormone and of thyroxine and triiodothyronine in blood of hypothyroid patients.	serum tsh values and the free concentration of t4 and t3 in serum expressed as the free t4- and t3-indices showed a curvilinear relationship in 24 patients with manifest hypothyroidism mainly due to extremely elevated serum tsh levels associated with very low thyroid hormone levels. the same degree of negative correlation was found between the log serum tsh concentration and serum free t4-index (r = -0.51, p less than 0.05) and between log serum tsh concentration and serum free t3-index (r = -0. ...	1978	581111
short-term effect of acetylsalicylic acid analogue on pituitary-thyroid axis and plasma cortisol level in healthy human volunteers.	the effect of acetylsalicylic acid analogue (aloxiprinum; superpyrin spofa) administered perorally in a daily dose of 1 g per 10 kg body weight on serum levels of free thyroxine (ft4), total thyroxine (t4), triiodothyronine (t3), cortisol (f) and thyrotrophin (tsh) was studied in healthy human volunteers. in a first experiment the drug was administered for 3 days to 7 subjects, the total daily dose being divided into 4-5 aliquots, while the same total dose was administered within 4 h to another ...	1978	581112
low serum thyroxine due to anti-thyroxine antibody.	in one case of untreated hashimoto's thyroiditis, the serum thyroxine (t4) value, obtained by radioimmunoassay (ria) employing resin to separate bound and free t4, was significantly lower than that obtained by competitive protein binding analysis (cpba). the discrepancy was found to be due to the presence of anti-thyroxine autoantibody in the serum. this phenomenon is considered to be of practical importance in interpreting the t4 value by ria in cases with autoimmune thyroid diseases.	1978	581194
t4 toxicosis in graves' disease.		1978	581293
[hyperthyroidism in older patients].	this study comprises 81 thyrotoxic patients with onset after the age of 60. in elderly persons, toxic multinodular goiter is the most common cause (68%) of hyperthyroidism, followed by solitary thyroid nodules (16%) and graves' disease (16%). cardiovascular disorders (cardiac failure, arrythmias etc.) constitute the first and often the only symptom in 62% of the cases. the other forms of appearance are both various and deceptive: depression, slight fever, asthenia or nausea. separate analysis of ...	1978	581312
[clinico-diagnostic considerations on lymphocytic thyroiditis. presentation of clinical cases].	personal experience with autoimmune lymphocyte thyroiditis, represented by 11 cases observed between 1972 and today, is reported. after some brief aetiopathogenetic notes on the lesions in question, the problems of diagnosing the nature of the thyropathy are stressed. after reviewing the examinations that have been proposed in the literature, it is noted that the preoperative recognition of a thyroiditis with autoimmune genesis is still problematical. the institution of a diagnostic protocol bas ...	1978	581513
genetic transformation of pilation and virulence into neisseria gonorrhoeae t4.	genetic transformation of nonpilated strains of neisserai gonorrhoeae to pilated forms is described. the transformants displayed phenotypic t1 and t2 colonial morphology on agar and possessed pili visualized by electron microscopy. when t1 or t2 transformant cells were injected into 11-day-old chicken embryos, they exhibited virulence characteristics only slightly less than the parental donor strains, though the parental recipient strains were avirulent. competence was maximal in the late log ph ...	1978	415054
thyroid-stimulating hormone (tsh), triiodothyronine (t3) and thyroxine (t4) response to intravenous and oral stimulation with synthetic thyrotropin-releasing hormone (trh) in young healthy adults.	tsh, t3 and t4 response to stimulation with thyrotropin releasing hormone (trh) has been investigated in 24 young healthy adults after intravenous injection and in 25 young healthy adults upon oral application of 40 mg of trh. after intravenous injection the tsh concentration raises from a mean of 1.6 to a mean maximum of 11.7 muu/ml. a statistically significant sex difference could not be found. t3 shows a statistically significant increase which is however too small to be of diagnostic value i ...	1978	415173
sporadic non-toxic goitre: an investigation of the hypothalamic-pituitary-thyroid axis.	thyrotrophin releasing hormone (trh) tests have been carried out on sixty-two patients with sporadic non-toxic nodular goitre. 61% gave a subnormal thyroid stimulating hormone (tsh) response but had normal plasma thyroxine (t4) and triiodothyronine (t3) levels. t3 administration suppressed 131i uptake by the thyroid adequately in 74% of these and there was normal stimulation of thyroid uptake by exogenous tsh. prolactin (prl) rose normally after trh in all the trh non-responders. normal tsh resp ...	1978	415831
effect of selective goitre resection on absent thyrotrophin response to thyrotrophin releasing hormone in idiopathic euthyroid goitres.	absent thyrotrophin (tsh) response to thyrotrophin releasing hormone (trh) was found in ten of fifty consecutive nodular goitrous patients who were clinically and biochemically euthyroid. these ten patients together with a reference group engaging fifty-eight healthy individuals matched for sex, age, and geographic region form the basis of the present study. patients with autonomously functioning single adenomata were excluded from the investigation. in the patient group, values of serum thyroxi ...	1978	415833
thyroxine-binding globulin, triiodothyronine, thyroxine and thyrotropin in newborn infants and children.	thyroxine-binding globulin (tbg), triiodothyronine (t3), thyroxine (t4) and thyrotropin (tsh) have been determined by radioimmunoassay in plasma of newborn infants and throughout childhood until puberty. mean maternal tbg concentration was 1.65 +/- 0.09 mg/100 ml (sem) and significantly higher (p less than 0.01) than cord blood levels of tbg (1.16 +/- 0.08 mg/100 ml (sem). throughout infancy and childhood tbg remained significantly elevated (p less than 0.01) compared to a middle age control gro ...	1978	415959
purification and properties of the bacteriophage t4 gene 31 protein required for prehead assembly.	a low molecular weight (approximately 16,000), early protein is characterized as the product of the essential t4 head assembly gene 31. this gene is known to be required to allow formation of any ordered head structure from the major t4 capsid protein, p23 (laemmli, u.k., beguin, f., and gujer-kellenberger, g. (1970) j. mol. biol. 47, 69-85). in wild type infection p31 synthesis ceases at late times; in contrast, p31 is overproduced in certain early or regulatory t4 mutant infections, particular ...	1978	416025
enzymatic synthesis of a segment of bacteriophage qbeta coat protein gene.	the oligoribonucleotide, a-a-a-c-u-u-u-gp, constituting a segment of rna bacteriophage qbeta coat protein gene was efficiently synthesized at a milligram scale by a combination of enzymatic methods using bacteriophage t4 rna ligase and the thermophilic polynucleotide phosphorylase. a-a-a-cp was synthesized from a-a-a and pcp by the newly developed mononucleotide addition method using t4 rna ligase in a yield of 83%, followed by dephosphorylation with bacterial alkaline phosphatase to obtain a-a- ...	1978	416426
extrathyroidal effects of propylthiouracil and carbimazole on serum t4, t3, reverse t3 and trh-induced tsh-release in man.	a possible extrathyroidal effect of propylthiouracil (ptu) and carbimazole on serum levels of thyroxine (t4), triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3) and on thyrotrophin-releasing hormone (trh) induced thyrotrophin (tsh) release was estimated in 19 patients with severe hypothyroidism treated with t4. during ptu medication a significant decrease in serum t3 from 90 +/- 16 (sd) to 79 +/- 23 ng/100 ml (p less than 0.01) and a reciprocal increase in serum reverse t3 from 51 +/- ...	1978	413302
parameters of thyroid function in patients with active acromegaly.	in order to determine if acromegaly per se may be associated with abnormalities in thyroidal economy, serum thyroxine-binding globulin (tbg), resin t3 uptake, total and free t4, t3, and reverse t3 concentrations were measured in 21 patients with active acromegaly. mean (+/- se) total t4, t3, and reverse t3 levels were 7.1 +/- 0.2 microgram/dl, 111 +/- 4 ng/dl, and 45 +/- 2 ng/dl, respectively, and the mean tbg concentration was 3.6 +/- 0.2 mg/dl. similarly, mean free t4, t3, and reverse t3 conce ...	1978	414050
mammalian tyrosinase. structural and functional interraltionship of isozymes.	the isozymes of tyrosinase from normal and malignant melanocytes were studied; the data indicates that each consists of a basic tyrosinase polypeptide, and differs by post-translational modifications. t3 represents the de novo form of the enzyme; it is converted to t1 in vivo by the addition of sialic acids and neutral sugars, and in turn, to t4 by complexing with mealanosomal membrane constituents. the t2 isomer is suggested to be an artefact of the electrophoretic procedure, and due to deamida ...	1978	414782
response to thyrotrophin releasing hormone in klinefelter's syndrome.	in eleven patients with klinefelter's syndrome tsh, t4 and t3 levels have been measured after stimulation with trh. the eleven patients included three who had been noted to have a low radioactive iodine uptake and two of these also had abnormally low t4 levels. three of the patients were receiving androgen replacement therapy. a normal response to trh was observed in all cases.	1978	416925
evidence for thyroidal secretion of 3,3',5'-triiodothyronine in man and its control by tsh.	thyroidal secretion of 3,3',5'-triiodothyronine (reverse t3, rt3) and its control by tsh was assessed by measuring (1) arterio-venous hormone gradients in patients undergoing surgery, (2) changes of hormone concentrations after induction of anaesthesia, and (3) changes induced by trh administration. in ten patients in whom thyroid activity was under tsh control (parathyroidectomy and non-toxic goitre) increased thyroid vein/carotid artery ratios (tv/ca) for rt3 (mean tv/ca ratio 2.53) were found ...	1978	416927
metabolism of thyroid hormones during aging.	the paper presents experimental data on extrathyroidal metabolism of thyroid hormones in rats of various ages (1.5--32 months):: t4-131i distribution in an organism, indices of t4 and t3 kinetics, tissue deiodinative capacity, formation of t4 tissue metabolism products and their clearance from cells and organism, t4 binding with tissue proteins. essential changes in t4 peripheral tissue metabolism have been found with aging: t4 binding by tissues is decreased; t4 distribution space and metabolic ...	1978	618772
dose-response studies on the inhibitory effect of thyroid hormones on insulin secretion in the rat.	dose-response studies have been performed to investigate the effect of thyroid hormones on insulin secretion from the rat pancreas with special reference to the time course of the hormone effect, doses of triiodothyronine (t3) and thyroxine (t4), and glucose concentration in the perfusion medium. the prominent effect of thyroid hormones was the inhibition of the late phase of glucose-induced insulin secretion. as the late phase comprises at least 98%-99% of insulin released from the pancreas dur ...	1978	619228
thyroid function in lung cancer.	thyroid function was assessed at the time of initial diagnosis in 204 patients with lung cancer and compared with that of age and sex-matched patients with non-malignant lung disease. abnormalities in thyroid function were found in 67 patients (33%). the most prevalent abnormality was a low t3 concentration; this was not associated with other clinical or biochemical evidence of hypothyroidism, but the short-term prognosis of these patients was worse than that of matched patients with lung cancer ...	1978	620266
nuclear binding of triiodothyronine and thyroxine in lymphocytes from subjects with hyperthyroidism, hypothyroidism and resistance to thyroid hormones.	binding of triiodothyronine (t3) and thyroxine (t4) to nuclei of intact human lymphocytes was studied. the binding characteristics were analysed by scatchard's method. in lymphocytes from euthyroid healthy subjects there was a single set of saturable nuclear t3 and t4 binding sites with an apparent mean equilibrium association constant of 3.3 x 10(10) l/mol and 1.7 x 10(10) l/mol, respectively. the estimated mean maximal specific binding capacity for t3 was 50 fmol/mg dna and for t4 was 55 fmol/ ...	1978	620467
modification of a screening program for neonatal hypothyroidism.	from our experience in the screening of 212,000 newborn infants, we have devised a flow chart for processing t4 and tsh measurements obtained from initial filter paper blood spots. to date, all infants with thyroid dysfunction or tbg deficiency have been detected. of the population screened, 1.84% require a spot tsh determination, and 1.1% require repeat determinations of t4.	1978	621609
revised location of the riii gene on the genetic map of bacteriophage t4.	two- and three-factor crosses showed that the t4 riii gene is located between genes 31 and 30 rather than between genes 31 and 63.	1978	621784
mutator and antimutator phenotypes of suppressed amber mutants in genes 32, 41, 44, 45, and 62 in bacteriophage t4.	bacteriophage t4 genes 32, 41, 44, 45, 56, and 62 are essential to dna replication. amber mutants (suppressed by su+1, su+2, or su+3 bacteria) in these genes were examined for any mutator or antimutator effects on the reversion of a transition mutation. in every case except for mutations in gene 56, elevated or lowered error frequencies were observed. these results indicate the importance of all of the replicative proteins in the determination of error frequency.	1978	621787
enhancement of fetal lung maturity by intra-amniotic administration of thyroid hormone.	following preliminary results in animal studies demonstrating that thyroxine (t4) injected directly into the fetus or the amniotic sac is capable of enhancing fetal lung maturity, a trial of thyroxine treatment in mean was carried out. two hundred micrograms of t4 were injected intra-amniotically in eight women with high-risk pregnancies in which premature delivery was inevitable or indicated. fetal lung maturity was evaluated by a recently developed, accurate, and rapid method using the microvi ...	1978	623168
increased urinary excretion of triiodothyronine (t3) and thyroxine (t4) and decreased serum thyreotropic hormone (tsh) induced by motion sickness.	we exposed 35 male subjects to a rotary chair and motion sickness was provoked by coriolis effect. this stress caused an increased excretion of urinary t3 and t4 and a decrease of tsh levels in serum. the increment in urinary excretion of thyroid hormones may serve as a very useful measure for the quantitation of physical stress. although no statistically significant change of t3, t4, and tbg levels in serum could be observed by the employed techniques, the hypothesis is favoured that motion sic ...	1978	623566
t4 polynucleotide ligase catalyzed joining of short synthetic dna duplexes at base-paired ends.	the self-complementary octanucleotide dt-a-g-t-a-c-t-a has been synthesized and its sequence confirmed by two-dimensional fingerprinting. under conditions used for the t4 polynucleotide ligase reaction, this oligonucleotide forms a dimeric duplex which shows a tm of 18 degrees c. the optimal rate of joining of the 32p-labeled duplex occurs between 12 and 15 degrees c. the rate is highly concentration dependent, as expected for a bimolecular process. polyacrylamide gel electrophoretic analysis of ...	1978	623741
interaction of normal and unusually modified microbial dna with cultured mammalian cells. breakdown and reincorporation vs. uptake of polymerized dna.	the uptake of radioactively labeled bacterial and phage dna and the incorporation of acid-soluble dnaase i digests of these dnas by cultures of human foreskin and 3t3 cells were studied. the presence of large amounts of unusually modified pyrimidine residues in donor phage dnas allowed radioactive donor dna in the nuclei of dna-treated cells to be distinguished from host dna labeled with breakdown products derived from donor dna. this distinction could be made because it was found that radioacti ...	1978	623763
thyroid hormone concentrations in a large scale community survey. effect of age, sex, illness and medication.	total thyroid hormone concentrations have been measured in the course of a large scale community survey to determine the distribution of these variables in the normal population and to assess the effect of age, sex, previously undectected thyroid disease and medication upon these parameters. 2779 subjects were studied. serum t4 concentrations were normally distributed. a progressive increase in t4 levels with age was noted in the males, and a smaller increase in females which was concealed by th ...	1978	624178
distant metastases in nasopharyngeal carcinoma.	three hundred and fifty-two consecutive cases of nasopharyngeal carcinoma were analysed to determine the pattern of distant metastases. diagnosis of distant metastases was made wholly on clinical signs and radiography. ninety-nine patients developed distant metastases, an incidence rate of 28.1%. there did not appear to be any difference in "risk" by age or sex. the predilection of this cancer to develop skeletal metastases is further confirmed. pulmonary and hepatic involvement were the next co ...	1978	624198
thyroid function tests in elderly hyperthyroid patients.	several tests of thyroid function were performed in 35 hyperthyroid patients over the age of 65 (elderly). the results were compared to those of similar tests in 48 hyperthyroid patients under the age of 65 (young). total serum thyroxine (t4) was within the normal range in 14 percent of the elderly and 11 percent of the young hyperthyroid patients. the free thyroxine index (fti) was within the normal range in 11 percent of both groups. the triiodothyronine uptake (t3u) proved to be a poor test i ...	1978	624818
structure of the lysozyme from bacteriophage t4: an electron density map at 2.4 a resolution.		1978	625058
neural and endocrine development after chronic tryptophan deficiency in rats: ii. pituitary-thyroid axis.	long-evans female rats, 21 days of age, were weaned and placed on a control (purina rat chow) diet, on a tryptophan deficient diet (t-) and on a diet complete in quality (purina rat chow) but restricted to the daily amount consumed by the rats on the t- diet (pair-feeding). all animals were maintained on these diets for 1 and 2 months and then one group of t- rats was returned to the complete (purina) diet and kept on this diet for several periods of time (up to 2 months). growth was interrupted ...	1978	625148
[contritution of correction to genetic recombination in t4 phage measured by the effect of map contraction].	marker-dependence of the fine structure map contraction in t4 phage is studied in two-factor crosses between riib mutants separated by indicator distances. the genetic intervals, which were short as compared with mean length of the heteroduplex region in hybrid dna molecules but which exceeded the length of the dna strand involved in a single correction event, were selected as indicator ones. on the basis of a deviation of measured frequencies from additivity (map contraction) the marker-specif ...	1978	627341
the usefulness of pretreatment dncb in 85 patients with squamous cell carcinoma of the upper aerodigestive tract.	pretreatment dncb skin testing and absolute lymphocyte counts were studied in 85 consecutive head and neck cancer patients. all patients were treated primarily with radiation therapy alone or combined radiation plus surgery. the results of dncb testing and absolute lymphocyte counts were not sufficiently predictive of outcome, (no evidence of disease after 2 years) to be useful in making treatment decisions on an individual patient. this applied to the good prognosis (t1, t2, n0-n3) and poor pro ...	1978	628221
[analysis of the neuronal activity of the lateral geniculate body in cats].	activity of the lateral geniculate body neurons was studied in immobilized cats. four parameters of impulse activity of every neuron were determined by computer analysis: t1, minimal, t2, average interspike intervals of the spontaneous activity, t3, latent period, and t4, duration of the first cluster of poststimulation activity. classification of neuronal groups was made according to these parameters. this classification was used as a basis for the construction of a scheme of neuronal interacti ...	1978	628469
pyrazole-induced thyroid necrosis: a distinct organ lesion.	one oral dose of pyrazole caused necrosis of rat thyroid follicular epithelial cells but spared the parafollicular (c) cells and the parathyroid glands. serum thyroxine (t4) and triiodothyronine (t3) were significantly decreased on day 3 after pyrazole administration and were immeasurable on day 5. at day 5 the thyroid was enlarged and the concentration of thyroid-stimulating hormone in the serum was increased, indicating an appropriate pituitary response to a primary lesion in the thyroid. dose ...	1978	628835
why does anyone still use desiccated thyroid usp?	the effect on thyroid status of changing from thyroid usp to sodium l-thyroxine was evaluated in 40 patients. with thyroid, abnormally high triiodothyronine (t3) levels were seen in 36 of 38 patients receiving doses of 90 to 240 mg; compared to sodium l-thyroxine, 0.15 to 0.2 mg, the serum t3 was higher (289 +/- 15 ng/dl versus 176 +/- 9 ng/dl, p less than 0.0005) and the thyroxine (t4) lower (7.4 +/- 0.3 microgram/dl versus 11.6 +/- 0.5 microgram/dl, p less than 0.01). thyrotoxic symptoms occur ...	1978	629277
[serum t4 determination with radioimmunoassay--studies of tetra-tab ria kit].		1978	630732
[bacteriophage t4 as a model for the study of cooperative movement processes].		1978	631007
reciprocal changes in serum free thyroxine fraction and thyrotropin level after administration of thiocyanate to rats.	the administration of thiocyanate to rats caused a significant increase of serum free thyroxine fraction, which coincided with the significant decrease of tsh level. the other components (aft4, t4, t3) in serum at this time were decreased or unchanged. the finding suggests the role of free thyroxine fraction in feed-back regulation of tsh secretion.	1978	631286
[a radioimmunoassay for the measurement of thyroglobulin in human serum and its application to clinical study (author's transl)].	a sensitive and specific double antibody radioimmunoassay for the measurement of serum thyroglobulin (tg) has been developed. the minimum detectable concentration of tg was 5.0 ng/ml. coefficients of within and between assay variation were 2.4% and 12.0%, respectively. the mean recovery of tg added to normal serum was 102.9%; and t4, t3, dit and mit did not crossreact in this assay system. dilution curves of normal thyroid extract, tumor extract and patient's serum were shown to be parallel with ...	1978	631380
effect of fasting on t3 and t4 concentrations in chicken serum.		1978	631553
structural changes in the t4 gene 32 protein induced by dna polynucleotides.	alterations in the structure of the dna-binding protein specified by gene 32 of bacteriophage t4 have been detected using partial trypsin digestion as a conformational probe. limited tryptic hydrolysis of the gene 32 protein removes a fragment ("b" region), of 21 amino acids from the nh2 terminus and a 6,200-dalton fragment ("a" region) from the cooh terminus. poly(dt), poly(dc), and single-stranded dna increase the rate of tryptic hydrolysis of the "a" region but decrease the rate of tryptic hy ...	1978	632279
serum thyroid hormone concentrations during prolonged reduction of dietary intake.	in nine obese but otherwise healthy subjects the effect of caloric restriction on the serum concentrations of thyroxine (t4), 3,3',5-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), urea, uric acid, creatinine, and bilirubin was studied. blood was obtained before and 2, 4, and 6 wk after the subjects had changed to a chemically defined diet (31 g amino acids, 44 g carbohydrate, and 1.5 g fat; 300 kcal/day). a decline of body weight to 88% and of serum t3 to 70% of the pretreatment values w ...	1978	634142
[determination of normalized t4 as a screening method for congenital hypothyroidism].		1978	634243
[serum concentrations of thyroid hormones in severe non-thyroidal illnesses (author's transl)].	pathologically low serum total triiodothyronine (t3) concentrations are a characteristic finding in patients with severe non-thyroidal illnesses. no adequate explanation has yet been offered for this phenomenon. we have, therefore, investigated the serum concentrations of total thyroxine (t4), total t3 and total 3,3',5'-triiodothyronine (reverse t3)--the metabolically-inactive metabolite of thyroxine--and of tsh in 13 patients with acute myocardial infarction, in 12 patients with compensated liv ...	1978	636438
the free triiodothyronine (t3) index.	in a large number of normal men (n = 111) and women (n = 110) the free triiodothyronine (t3), index, calculated from serum total t3 and t3-uptake, was highly correlated with free t3, measured by equilibrium dialysis. the correlation was almost as high as that of the free thyroxine (t4) index with free t4. the correlations of the total t3, free t3, and free t3 index with, respectively, the total t4, free t4, and free t4 index were much lower, though still statistically significant. the free t3 in ...	1978	637426
an analysis of factors in the successful management of cancer of tonsillar region.	a total of 117 consecutive primary cancers of the tonsillar region was irradiated at the university of illinois hospitals from 1955 to 1973. results with 94 patients treated with radiotherapy alone and 23 with a combination of surgery and radiotherapy were analyzed. the modalities of radiation used were electron beam, 22 mev photons and cobalt-60. lymph node metastases were noted in 70% of the patients at the initial examination. in patients treated with radiation alone the determinant 5-year su ...	1978	638946
immune and non-immune t4 radioassays utilizing albumin magnetic microparticles.	albumin magnetic microparticles reversibly adsorb thyroxine. they quickly establish equilibrium allowing time and temperature independent measurements in t4 radioassays. we used these particles to compare the efficiency of naoh, hcl, pepsin, sodium trichloroacetate, and 8-anilino-1-naphthalene sulfonic acid to release 125i-t4 from serum, t4-free serum and human serum albumin. we found that the efficiency of the reagents to extract 125i-t4 depended on the concentration and type of proteins to whi ...	1978	639318
effects of iodides on the hypothalamic-pituitary-thyroid axis in neurological endemic cretinism: evidence for compensated thyroidal failure in adult life.	thyroid function studies, performed after iodide administration to five patients with neurological endemic cretinism, were indicative of hypothyroidism. all five subjects had either a low serum thyroxine (t4) or a high basal thyrotrophin (tsh) level and a clearly exaggerated tsh response to thyrotrophin releasing hormone (trh). these findings are in sharp contrast with those we have previously described in goitrous patients without cretinism from the same geographical area. one interpretation of ...	1978	639333
thyroid function and blood pressure in two new strains of spontaneously hypertensive and normotensive rats.	1. the influence of thryoid function on the development of hypertension was studied in strains of spontaneously hypertensive (sh) and normotensive rats. 2. surgical thyroidectomy decreased systolic blood pressure more markedly in sh rats than in normotensive rats. the effects of oral administration of 5 and 100 micrograms of thyroxine 24 h-1 100 g-1 were studied in the thyroidectomized animals. in the two strains the blood pressure returned to control levels only after administration of the larg ...	1978	639469
the structure of phage t4 lysozyme in solution noticeably differs from its crystalline struction.		1978	639977
the optic nerve of the brush-tailed possum, trichosurus vulpecula: fibre diameter spectrum and conduction latency groups.	the principal findings of this report on the morphology and electrophysiology of the possum optic nerve are: (i) there are about 230,000 fibres in the optic nerve. this fibre count, based on electron microscopy, is slightly less than a previously reported estimate of the total number of ganglion cells in the possum retina. (ii) the majority (greater than 98%) of the fibres of the optic nerve are myelinated axons of retinal ganglion cells. the diameters of these fibres range from 0.4--4.6 microme ...	1978	641234
complete primary structure of the small outer capsid (soc) protein of bacteriophage t4.		1978	642009
head maturation pathway of bacteriophages t4 and t2. iii. isolation and characterization of particles produced by mutants in gene 17.	we have isolated and characterized two types of particles produced in comparable amounts by mutants in gene 17: the empty large particle and the empty small particle. dimensions, morphology, stability, and protein composition of the empty large particle are very similar to those of the capsids or empty heads of mature phage. the other type of particle (empty small particle) is very similar in dimensions and stability to the prehead, but differs in that it is composed of processed proteins (gp23, ...	1978	642076
screening for congenital hypothyroidism. results in the newborn population of new england.	during the first year of operation, the new england regional hypothyroidism screening program determined the concentration of thyroxine (t4) levels in dried blood on filter paper from 129,028 infants born in connecticut, maine, massachusetts, new hampshire, and rhode island. specimens from approximately 3,800 neonates were found to have levels of t4 below the lower limit of normal (less than 6.0 microgram/dl) and were assayed for thyroid-stimulating hormone (tsh) content. levels of tsh were elev ...	1978	642171
[determinations of plasma tsh, t4, t3, cortisol and hgh in 2 anencephalic newborn infants].		1978	642898
[breast cancer in the male (author's transl)].	the prognosis of breast cancer in the male is considerably worse than in the female. the longer neglect and the quicker formation of metastases are responsible for it. modified radical mastectomy is the procedure of choice up to stage t3. in stage t4 only mastectomy should be performed. radiotherapy with the megavolt technique is necessary in any case. the experience with castration, adrenalectomy and hypophysectomy is limited, further experience must be awaited.	1978	645271
t3 thyrotoxicosis in a child.	we report the case of a 5-year-old hyperthyroid boy with normal serum t4 levels are elevated serum t3 levels. the findings are diagnostic of t3 thyrotoxicosis, a condition that has been very infrequently reported in childhood. we postulate that low dietary iodine intake may be an etiologic factor in some cases of t3 thyrotoxicosis.	1978	645654
metastatic squamous cell carcinoma of the lip.	squamous cell carcinoma of the lip is a common lesion that is not always acknowledged as a potentially lethal disease. we reviewed the cases of 27 patients with metastatic squamous cell carcinoma of the lip. our data confirm that patients in an older age group are at greater risk for development of metastases than the general population of patients with squamous cell carcinoma of the lip. we also found a universally grave prognosis for patients who exhibit fixation of tumor to the mandible or er ...	1978	646724
a unified theory of nucleation-rate-limited dna renaturation kinetics.	dna renaturations under nucleation-rate-limiting conditions on simple dna such as bacterial and bacteriophage dna show significant deviation from ideal second-order kinetics when followed by optical density measurements at 260 nm. ideal second-order kinetics yield linear plots when the data is plotted in the standard reciprocal second-order (rso) manner. the observed deviations from ideal second-order behavior take the form of steadily downward-curving rso plots. in this paper, experiments are p ...	1978	647102
[determination of serum thyroxine by t4 peg ria-pack].		1978	648000
propranolol withdrawal and thyroid hormones in patients with essential hypertension.	the effect of abrupt withdrawal of propranolol on serum concentrations of triiodothyronine (t3) and thyroxine (t4) was investigated in 5 patients with uncomplicated essential hypertension. the patients had been treated from 2 to 18 mo before the study was begun. doses varied from 160 to 480 mg propranolol daily. four of the patients studied developed tachycardia, sweating, or tremor within 2 to 6 days after withdrawal of propranolol. in 1 patient reversible ischemic ecg changes were recorded. th ...	1978	648076
age-related glucose intolerance in hyperthyroid patients.	in an attempt to study age-related metabolic abnormalities, glucose intolerance and serum insulin were examined in normal subjects and hyperthyroid patients. for comparison, serum concentrations of thyroxine (t4), triiodothyronine (t3), and total cholesterol were also measured in normal subjects and hyperthyroid patients. although serum t4 concentration remained unchanged, serum t3 concentration decreased significantly in an elderly group of normal subjects. similarly, serum t4 did not change wi ...	1978	648744
the effect of thyroid hormones on rat pineal indoleamine metabolism in vitro.	the effect of tsh, triiodothyronine (t3) and thyroxine (t4) on basic and noradrenaline (na)-induced indoleamine metabolism was investigated in rat pineal culture based on the observation that, under the experimental system used, melatonin is formed from its amino acid precursor tryptophan. when added to the culture medium, alone or in the presence of na, tsh in dosages of 5 and 20 mu had no significant effect on pineal tryptophan metabolism.t4 and 2.5 microgram increased the melatonin concentrat ...	1978	650203
neonatal thyrotoxicosis: alterations in serum concentrations of lats-protector, t4, t3, reverse t3, and 3,3't2.		1978	650321
binding of the structural protein soc to the head shell of bacteriophage t4.		1978	650689
[results of therapy in cases of tumors of the nasal cavity and paranasal sinuses in relation to different tumor classifications (author's transl)].	the primary findings in 128 patients with malignancies of the nasal cavity and the paranasal sinuses were classified by 4 tumor classifications. the survival times and the rates of recurrences in relation to the stage of tumor were compared. mostly cancers of advanced stages t3 and t4 with bad prognosis were treated: only 35% of the examined patients survived longer than 5 years. there was no obvious difference in the results of therapy in tumor cases t3 and t4 in relation to the different tumor ...	1978	651499
[study of thyroxine synthesis in non-toxic goiters using dispersed thyroid cells (author's transl)].	the ability of thyroid tissue from non-toxic goiter to synthesis thyroid hormones was investigated by measuring 131 i-iodide incorporation in t4 in dispersed thyroid cell system. dispersed thyroid cells were prepared by trypsinization from 5 pathological and 2 normal thyroid specimens. the patients with non-toxic goiter were euthyroid or in mild hypothyroidism. the capacity of t4 synthesis was decreased in 4 cases and increased in 1 as compared to that of normal thyroid tissue. in one case, the ...	1978	655613
[interference of t4 in different serum t3 radioimmunologic determination kits].	the cross reactivity of t3 antibodies for t4 was studied with five t3 ria kits. t4 used was provided from t4 ria kits (abbot beckman, corning). the results are shown on the table indicating the concentration of t3 or t4 required to displace 50% of the t3 125 from anti t3. the cross reactivity for t4 of t3 antibodies from lepetit and phadebas was the same and was smaller than cross reactivity with the other laboratories. in clinical practice serum t4 levels of hypo and euthyroid subjects are not ...	1978	655615
[in vitro synthesis of 3,5,3'-triiodothyronine catalyzed by thyroid peroxidase (author's transl)].	3,5,3'-triiodotyronine formation was studied in vitro after iodination of goiter thyroglobulin catalyzed by purified thyroid peroxidase. a fractionnal number of t3 is always obtained per mole of thyroglobulin in both in vitro and in vivo. this result cannot be explained by a heterogeneity in thyroglobulin iodination or in a partial conversion of t3 to t4. it is suggested that thyroglobulin is heterogenous either in its primary sequence or in its teritiary configuration. thyroglobulin contains ty ...	1978	655617
[fetal and neonatal triiodothyronine (author's transl)].	thyroid hormones of amniotic fluids give informations about their presence in the fetus. t3 and t4, determined by radioimmunoassay, are found as soon as 12 weeks of gestation. their amounts are higher at 17 weeks than at 30-40 weeks of gestation. thyroid tissues of premature and full term neonates were analysed by chromatography after hydrolysis and 127i determined. t3 amount was very low near birth and increased with duration of survival. these results may be related to hormonal serum changes o ...	1978	655618
[serum t4, t3, rt3 and t.s.h. concentration in cancer (author's transl)].		1978	655619
[the low serum triiodothyronine syndrome in nonthyroid diseases. distribution of plasma tsh concentrations].	t3 serum concentrations (ria) was low in 25 cases and normal low in 10 among 57 patients with serious systemic illnesses. these 35 patients were in clinical euthyroid state and had a normal t4 serum concentration and f.t.i. t.s.h. serum concentration was normal in 28 cases of 31 low t3 syndrome observed.	1978	655621
effect of atp analogues on t4 polynucleotide ligase.		1978	656099
use of ethidium bromide fluorescence enhancement to detect duplex dna and dna bacteriophages during zone sedimentation in sucrose gradients: molecular weight of dna as a function of sedimentation rate.	duplex dna molecules and dna bacteriophages have been sedimented through 5--25% sucrose gradients containing ethidium bromide. the location of dna within the gradients has been determined by illuminating gradients with ultraviolet light and observing the ethidium bromide fluorescence enhancement induced by the dna. the relative sedimentation rates of linear, duplex dnas from bacteriophages t4, t5, t7 and an 8.3% t7 deletion mutant have been determined. the distances sedimented by dna have been c ...	1978	656381
excision repair of ultraviolet damage in mammalian cells. evidence for two steps in the excision of pyrimidine dimers.	the incidence of pyrimidine dimer formation and the kinetics of dna repair in african green monkey kidney cv-1 cells after ultraviolet (uv) irradiation were studied by measuring survival, t4 endonuclease v-sensitive sites, the fraction of pyrimidine dimers in acid-insoluble dna as determined by thin layer chromatography (tlc), and repair replication. cv-1 cells exhibit a survival curve with extrapolation number n = 7.8 and do = 2.5 j/m2. pyrimidine dimers were lost from acid-insoluble dna more s ...	1978	656544
red cell 2,3-diphosphoglycerate and oxygen affinity of hemoglobin in patients with thyroid disorders.	we measured red blood cell 2,3-diphosphoglycerate (2,3-dpg), adenosine triphosphate (atp), and the p50 value in vitro of the oxyhemoglobin dissociation curve, which is the oxygen tension at half saturation of hemoglobin, in order to quantitate red blood cell oxygen transport function in individuals who were diagnosed as hypothyroid, euthyroid, or hyperthyroid based on measurements of thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), and their clinical status. hypothyroid (mean t4 2.8 mic ...	1978	656626
investigations on the deiodination of thyroxine (t4) to 3,3'-diiodothyronine (3,3'-t2) in rat liver homogenate.	properties of an inactivating pathway of t4 to 3,3'-diiodothyronine (t2') in rat liver homogenate are described. the intermediate product (of this reaction sequence) is reverse t3 (rt3) which is very labile and cannot be measured at ph 7.5. the apparent km of the reaction rt3 to t2' is 2 x 10(-8) m. the activities catalyzing the reactions t4 to t3, t4 to t2' and rt3 to t2' are found in the 100 000 x g pellet. propylthiouracil inhibits all three activities to a similar degree; alpha-methyl-p-tyro ...	1978	657520
[serum t4 determination with thyroxine (t4) "eiken"--experimental and clinical studies].		1978	657558
uv-induced mutation in bacteriophage t4.	two late gene am mutants of bacteriophage t4 that can be induced to revert by uv were crossed to a temperature-sensitive ligase mutant. in the double mutants, uv-induced reversion was eliminated at a semirestrictive temperature. when the single am mutants were irradiated and then allowed a single passage in a permissive host, the uv-induced reversion frequency was increased by 15- to 25-fold. this increased mutagenesis was also abolished by the presence of the ligase allele. when the uv-irradiat ...	1978	660716
head maturation pathway of bacteriophages t4 and t2. iv. in vitro transformation of t4 head-related particles produced by mutants in gene 17 to capsid-like structures.	t4 mutants in gene 17 accumulate particles which contain the main head protein in the cleaved form (gp23*) arranged in an unexpanded lattice (empty small particles), together with other expanded capsids (empty large particles). the isolated empty small particles can be transformed in vitro, by lowering the ionic strength, to capsid-like structures. this structural transformaton is not coupled to chemical modification of the structural proteins of the empty small particles. in contrast to unexpan ...	1978	660719
[neonatal screening for hypothyroidism. preliminary results from different methods (author's transl)].	in a regional study 2062 newborns were screened for congenital hypothyroidism by determination of tsh in plasma or dried blood spots on the fifth day of life. three newborns with congenital hypothyroidism were detected. all of them showed high tsh-levels between 462 and 2192 micromicron/ml. one newborn with a congenital goiter had a tsh-level of 143 micromicron/ml. additionally, in a follow-up study of 50 newborns with jaundice tsh, t4, t3 and reverse t3 during the first 120 h of life were measu ...	1978	661833
in vitro transcription and isolation of a polycistronic rna product of the t4 trna operon.		1978	661965