Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| transient hypothyroidism associated with prematurity, sepsis, and respiratory distress. | serial tsh and t4 determinations were performed in sixty neonates admitted to our hospital for neonatal intensive care within a period of three months. seven patients (12%) showed transient hypothyroidism on the basis of low t4 and high tsh values. only one of these patients, who had meconium aspiration and pneumonia, did not have the respiratory distress syndrome. in addition, 4 of these patients had sepsis. all of the patients were born before 37 gestational weeks and had birth weights under 2 ... | 1979 | 499263 |
| [triiodothyronine (t3) 3,3',5'-l reverse triiodothyronine (rt3), thyroxine (t4) and free thyroxine index (ft4-i) levels in the blood serum of pregnant women]. | 1979 | 499891 | |
| histochemical study on the localization of glucose-6-phosphate dehydrogenase induced by androgen or thyroxine in the convoluted tubules of mouse submandibular gland. | the effects of 5 alpha-dihydrotestosterone (dht) and thyroxine (t4) on glucose-6-phosphate dehydrogenase (g-6-pdh) activity in mouse submandibular gland were investigated histochemically. a strong positive histochemical reaction for g-6-pdh was observed in the excretory ducts of untreated male and female mice, with a slight reaction in the basal portion of the convoluted tubules (striated ducts) of males. administration of dht to female mice increased g-6-pdh activity specifically in the convolu ... | 1979 | 500409 |
| hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses. | the effect of testosterone (dt) and thyroxin (l-t4) on erythropoiesis and erythropoietin (ep) production was studied in control and nephrectomized sheep fetuses beginning at about 100 d of gestation. fetuses were given injections of either 1.2 mg/d x 13 of l-t4, 12 mg, once every 5 d x 3 of dt or the vehicle alone. fetal plasma samples for ep determinations were obtained before and at intervals after the start of the treatment. reticulocyte and hematocrit levels, and the percent erythrocyte-59fe ... | 1979 | 500805 |
| cleavage map of bacteriophage t4 cytosine-containing dna by sequence-specific endonucleases sali and kpni. | cytosine-containing t4 dna from endoii- endoiv- dctpase- alc2 phage grown in a sup+ rb- mb- host is cleaved by endo r.ecori and endo r.hindiii to greater than 40 fragments and by endo r.sali and endo r.kpni to 8 and 6 fragments, respectively. the latter two fragment sets have been correlated to each other to produce a cleavage map of the genome. the sum of the molecular weights of the fragments calculated from electrophoretic mobility in agarose gels yields a genome molecular weight for cytosine ... | 1979 | 501794 |
| [problems of radioimmunoassay of t3, t4 and tsh (author's transl)]. | 1979 | 502033 | |
| [fundamental study for t3-rsu, t3, t4 and tsh measurement method (author's transl)]. | 1979 | 502034 | |
| the course of untreated mild t3 toxicosis. | a selected group of 12 patients with mild t3 toxicosis, has been assessed without treatment during a period of from seven to 38 months. progression to typical hyperthyroidism with combined t4 and t3 excess occurred in one case of solitary toxic adenoma, while a spontaneous remission with return of the thyrotropin response to thyrotropin-releasing hormone occurred in one patient with a diffuse goitre. the other 10 patients showed persistence of isolated high levels of t3 without clinical or bioch ... | 1979 | 502952 |
| [tsh, t3 and t4 serum concentration in children living in two endemic goiter areas (author's transl)]. | 1979 | 504836 | |
| [further investigations concerning the reaction between haptoglobin and t4-antigen-carrying streptocci (author's transl)]. | the median level of haptoglobin types 2-2 and 2-1 was found to be proportional to the agglutination titer of t4 antigen-carrying streptococci (fig. 1). this relationship need not exist in individual sera since, as seen from table 1, high agglutination titers may be caused by sera with low levels of haptoglobin. thus the agglutination reaction might depend not only on the quantity of haptoglobin but also on other factor(s) (at least in individual serum samples). - on the other hand, different agg ... | 1979 | 506546 |
| variations in plasma thyroxine concentrations throughout one year in penned sheep on a uniform feed intake. | plasma total thyroxine (t4) concentrations were measured by radioimmunoassay throughout one year in 10 sheep maintained indoors under natural light and consuming a constant amount of feed. plasma t4 concentrations varied throughout the year, the highest and lowest values occurring in the spring and autumn months respectively. the mean of all observations was 5.4 +/- 0.1 microgram/dl. the changes observed did not appear to correlate with changes in ambient temperature, day length or with reported ... | 1979 | 508210 |
| the effect of propylthiouracil on thyroid-stimulating hormone-induced alterations in iodothyronine secretion from perfused dog thyroids. | the aim of this study was to see whether the inhibitory effect of propylthiouracil on thyroidal secretion of 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) could be reproduced in intensively stimulated thyroids, and to elucidate whether an increase in the fractional deiodination of thyroxine (t4) to t3 and rt3 during iodothyronine secretion might be responsible for the transient fall in the t4/t3 and t4/rt3 ratios in thyroid secretion seen in the early phase after stimulation of ... | 1979 | 508809 |
| dissociated thyroxine, triiodothyronine and reverse triiodothyronine levels in patients with familial goitre due to iodide organification defects. | the thyroid function of patients with three different types of organification defect was studied. all patients were characterized by a high thyroidal 131i uptake and a positive perchlorate discharge. patients with pendred's syndrome who had goitre and congenital nerve deafness were mostly euthyroid with normal circulating thyroid hormone levels. only two of them had compensated euthyroidism with elevated total t3, high basal tsh and delayed return to basal value with trh. the patients who were e ... | 1979 | 509742 |
| molecular conformation of thyroid hormones: structure and binding interactions of thyroxine. | in an accurately determined x-ray diffraction study of the thyroid hormone thyroxine (t4), the two independent conformations in the crystal lattice show significant differences in the outer phenyl ring geometry when compared with that of 3,5,3'-triiodothyronine (t3). the major differences between the t4 and t3 structures are a shortened c4'-o4' bond, contraction of the c3'-c4'-c5' angle and an increase in the c3' and c5' angles of t4. these changes can be correlated with the difference in acidit ... | 1979 | 510217 |
| the distal half of the tail fibre of bacteriophage t4. rigidly linked domains and cross-beta structure. | 1979 | 513135 | |
| rega protein of bacteriophage t4d: identification, schedule of synthesis, and autogenous regulation. | proteins labeled with 14c-amino acids after infection of escherichia coli b by t4 phage were examined by electrophoresis in the presence of sodium dodecyl sulfate. four rega mutants (rega1, rega8, rega11, and rega15) failed to make a protein having a molecular weight of about 12,000, whereas mutant rega9 did make such a protein; rega15 produced a new, apparently smaller protein that was presumably a nonsense fragment, whereas rega11 produced a new, apparently larger protein. we conclude that the ... | 1979 | 513206 |
| [functional activity of the hypophyseal-thyroid system in oncological patients]. | studies of the hypophyseal-thyroid system in patients with cancer of the lung, stomach, mammary gland have revealed similar changes, manifested in the increased tth concentration with simultaneous fall in the t3 and t4 content with the resultant increase of tth/t3 and ttj/t4 coefficients. the changes observed are characteristic of oncological patients only and may be used for diagnostic purposes. | 1979 | 516575 |
| effects of three-day oral cholecystography on serum iodothyronines and tsh concentrations: comparison of the effects among some cholecystographic agents and the effects of iopanoic acid on the pituitary-thyroid axis. | the effects of repeated doses of oral cholecystographic agents on serum thyroxine (t4), 3,3',5-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3) and thyrotrophin (tsh) concentrations were studied in 37 euthyroid male subjects. iobenzamic acid, tyropanoic acid, iopanoic acid, and ipodate sodium, in a dosage of 3 g for 3 days, respectively, induced a significant decrease in serum t3 and an increase in rt3 within 24 h after the initial dose, followed by an increase in tsh and a slight increase ... | 1979 | 517049 |
| preparation of thyroxine (t4) and triiodothyroxine (t3) free serum avoiding charcoal fines. | 1979 | 517987 | |
| [in vivo regulation by calcium of the thyroidal iodine metabolism and its modulation by sodium, in the rat (author's transl)]. | in vivo experiments, in the rat, using diets deficient in calcium, or sodium or both ions, proved these cations to regulate the thyroidal iodine metabolism. calcium enhanced iodine entry into the thyroid and the intrathyroidal iodine and t4 pools. t4 level in serum was also increased by calcium. sodium enhanced iodine entry and secretion. the two cations have local regulatory functions on the thyroid gland and do not affect tsh levels in serum and the hypophysis. the effects of calcium and sodiu ... | 1979 | 518018 |
| [immunoreactive somatostatin in rat hypophysial portal blood (author's transl)]. | somatostatin levels have been determined by radioimmunoassay in hypophysial portal blood of pentobarbital-anesthetized male rats. in euthyroid rats, the mean level was 158 +/- 27 pg/ml (n = 8); somatostatin was undetectable (less than 30 pg/ml) in systemic blood of these rats. thyroidectomy and excess of t4 did not modify the levels of somatostatin in hypophysial portal blood. | 1979 | 518025 |
| [neonatal screening for hypothyroidism by simultaneous determination of t4 and tsh on filter paper (author's transl)]. | a simultaneous determination of t4 and tsh has been done on 48 000 new borns since january 1st of 1977 in the midi-pyrénées district. 15 cases of hypothyroidism have been detected, an incidence of 1/3 200 new borns. tsh values always were above 80 microu/ml; t4 values are under m-2 sigma in 11 cases, normal in 2 cases (8,8 and 9 micrograms/dl) and between -1 and - 2 sigma in 2 cases. a thyroid scanning with 123 odine or 99 tech, has shown the absence of thyroid in 6 cases, an ectopic gland in 7 ... | 1979 | 518030 |
| [problems encountered during intensive routine scale performace of paper t4 and tsh radioimmunoassays (author's transl)]. | high sensitivity attained in radioimmunoassays explains the important role played by specialized laboratories as screening partners for early neonatal hypothyroidism detection. in this paper, the author tries to point out optimal technical conditions to be followed while performing at routine scale t4 and tsh paper immunoassays choice of filter paper, blood collection and storage, assay, quality control, assay mecanization, computer calculation of results). | 1979 | 518031 |
| influence of age on the endocrine-metabolic response to surgery. | the pathogenesis of the increased operative risk in elderly patients is unknown. from a theoretical point of view, a change in endocrine-metabolic response might be involved. in the present study, a battery of hormonal and metabolic variables were measured in eight young and eight elderly healthy males undergoing elective inguinal hernial repair under general anesthesia. blood was drawn before induction of anesthesia, at skin incision, and one, two, and six hours after skin incision. the finding ... | 1979 | 518178 |
| energy cost of ambulation in paraplegic patients using craig-scott braces. | energy metabolism data were collected in a series of 8 male paraplegic patients with neurologically complete spinal cord lesions between t4 and t12 (1 patient had complete motor paralysis with incomplete sensory function). energy costs were measured at the subject's seated basal rate (mean = 17.12cal/min/kg) and during 2 separate trials at ambulation using craig-scott braces. the rates of ambulation reflected the patient's perceived comfortable rate and ranged from 2.2 to 44.8m/min. (mean = 14m/ ... | 1979 | 518268 |
| [fundamental and clinical evaluation of spac t4 radioimmunoassay kit (author's transl)]. | 1979 | 519888 | |
| effect of thyroxine treatment on metabolic responses to a single insulin injection. | metabolic responses to a single i.v. injection of cristalline insulin (0.2 i.u./kg b.w.) were compared in control and t4-treated dogs both at rest and after prolonged physical exercise. the post-insulin decrease in blood glucose was significantly correlated with the pre-insulin bg concentration. thus, the insulin-induced fall of bg was greatest in t4-treated dogs at rest, in which significantly higher bg levels were found in comparison with controls, and smallest in the same dogs after exercise, ... | 1979 | 521011 |
| effect of neonatal administration of thyroxine on the rate of sebum production in rats. | newborn sprague-dawley rats of both sexes were treated with 28 micrograms thyroxine (t4) daily for the first week of life. at the age of 80 days, the secretion rate of sebum was measured from the amount of skin-surface lipids extractable by acetone and which had been produced during 2 days. treatment with such excess amounts of t4 during the early postnatal period significantly reduced the production of sebum in both male and female rats when compared with control rats and with rats deprived of ... | 1979 | 521736 |
| physiological changes in caged layers during a forced molt. 3. plasma thyroxine, plasma triiodothyronine, adrenal cholesterol, and total adrenal steroids. | the effects of forced molting on plasma levels of thyroxine (t4), triiodothyronine (t3), and adrenal cholesterol and total adrenal steroid content were studied. commercially available strains of single comb white leghorn (scwl) hens, reared and maintained under commercial conditions, were used in the three trials. the hens were moved to environmentally modified facilities prior to the forced molt which was accomplished by reducing daylength and by withdrawing feed and water. egg production cease ... | 1979 | 523391 |
| serum thyroxine, triiodothyronine and thyroid stimulating hormone after prolonged heavy exercise. | serum thyroxine (t4), triiodothyronine (t3) and thyroid stimulating hormone (tsh) was measured before, immediately after and on the following days after a 70 km cross-country ski race in two groups of ten well-trained men, one aged 21--29 years, taking 5.01--7.03 h, and one aged 51--57 years, taking 6.07--7.38 h. t4 was definitely increased immediately after the race, but fell to below the initial level on the following day and was not restored to the pre-race level until 4 days after the race. ... | 1979 | 523989 |
| labeling of lymphocyte surface immunoglobulins with t4 as marker for scanning electron microscopy. | the technique originally described by kumon et al. for the labeling of cell surface antigens under the sem has been adapted to the study of surface immunoglobulins on human lymphocytes. briefly, the peripheral blood lymphocytes are: 1) separated in a ficoll hypaque gradient, 2) rinsed with culture medium, 3) allowed to attach to plastic coverslips, 4) prefixed with 1% glutaraldehyde for 10 minutes, 5) incubated with goat anti-human immunoglobulins for 30 minutes at 24 degrees c, 6) rinsed, 7) in ... | 1979 | 524028 |
| [strategy and results in the treatment of squamous cell carcinoma of the anal canal. a review of 51 cases (author's transl)]. | in this retrospective study of 51 patients treated for squamous cell carcinoma of the anal canal some aspects of the natural history are touched upon. the authors also discuss their results and define their current therapeutic approach. it is a rare lesion; only 2-3% of all colorectal cancers with a predominance for women (4 to 1) and of 2 histological varieties. the epidermoid type (74%) is made more prevalent though the basal layer type (26%). the prognosis is very poor once the stage t, is pa ... | 1979 | 525165 |
| serum thyroxine (t4) and triiodothyronine (t3) uptake values in normal adult cats as determined by radioimmunoassay. | radioimmunoassay procedures employing highly specific antibodies for either serum t4 or t3 were utilized to determine t4 concentrations and t3 uptake values in normal cats. mean values for serum t4 and for t3 uptake were 30.9 ng/ml +/- 19 ng/ml and 59.67% +/- 12.2%, respectively. | 1979 | 525869 |
| supraglottic surgery in vestibular cancer. | this paper deals with the experience acquired in the e.n.t. clinic of the university of ferrara regarding horizontal supraglottic laryngectomy in vestibular cancer. the anatomical background of this functional surgery and the most important principles of the technique are specified. the results regard 121 cases (13 t1 cases, 93 t2 cases and 15 t4 cases) divided into three groups: 1. patients who had only surgery (68 cases); 2. patients who for various reasons also had complementary postoperative ... | 1979 | 526185 |
| [screening for cretinism using clinical check-list and measurement of t4 in filter paper blood sample (author's transl)]. | 1979 | 527236 | |
| comparison of t4, t3, rt3 and tsh concentrations in cord blood and serum of infants up to 3 months of age. | t4, t3, tsh and rt3 concentrations were measured by radioimmunoassay in cord and postnatal (8--94 days of age) serum samples from randomly selected normal newborn infants (group i). t4 and tsh levels also were determined in cord and postnatal sera from an additional group of apparently healthy infants 8--260 days of age, whose cord serum t4 levels were in the upper or lower 10% of the normal range of values (group ii). postnatal t4, t3 and tsh concentrations were stable over this age range; ther ... | 1979 | 527526 |
| effect of l-thyroxine treatment on the levels of various hepatic metabolites in rats. | the effects of l-thyroxine (t4) treatment upon hepatic metabolism of control and t4 treated rats was studied. livers were excised and freeze-clamped rapidly. the levels of adenine nucleotides and glycolytic and tca cycle metabolites were determined. the redox ratios of free pyridine nucleotides of cytoplasm and mitochondria were calculated from selected substrate concentrations. t4 treatment resulted in lower phosphorylation states and caused reduction in ratios of cytoplasmic nad and nadp and r ... | 1979 | 528840 |
| microdot t4 testing. | 1979 | 530243 | |
| endocrinology of pregnancy. i. denominations of concentrations of triiodothyronine, thyroxine, effective thyroxine, thyreotrophin and growth hormone in normal pregnancy, labour and in cord blood. | concentrations and activities of the following agents were estimated: triiodothyronine (t3), thyroxine (t4), effective thyroxine (etr), thyreotrophin (tsh), and growth hormone (hgh). blood samples were collected in pregnancy, labour and from the umbilical cord of the newborns. it was demonstrated that in normal pregnancy the concentrations of t3, etr, and tsh did not differ significantly from the values considered as normal in non-pregnant women. the concentration of t4 was distinctly higher in ... | 1979 | 532436 |
| haptoglobins act similar to antibodies. steps of discovery. analogous conclusions from pure preparations, umbilical cord sera and animal sera. | the haptoglobins in man and in mammals are agglutinin-like-substances for streptococci having the t4 antigen. the kind of the agglutinin-like behaviour depends on the genetic type of the haptoglobins. haptoglobins of the types hp 2-2, hp 2-2 like and hp 2-1 are hightitred complete agglutinins (titre in the range between 1:200 up to 1:3000 and higher) whereas haptoglobins of the type hp 1-1 are "blocking antibodies". - the steps of the discovery and evidence are presented in detail. different que ... | 1979 | 532442 |
| solubilization of thyroxine-5'-deiodinase activity from rat liver microsome fraction. | the greater part of t3 is converted from t4 in liver or kidney. the majority of this activity exists in microsomal fraction. in the present study, we investigated whether this activity can be solubilized from rat liver microsomal pellet with various concentrations of deoxycholate (doc). the extent of solubilization was compared with that of protein, rotenone insensitive nadh cytochrome c reductase or nadh cytochrome b5 reductase, which have been shown to associate with microsomal membrane rather ... | 1979 | 532525 |
| transient infantile hyperthyrotropinaemia. report of a case. | a case of transient hyperthyrotropinaemia was found by mass screening for neonatal hypothyroidism using the paired tsh assay method. the patient was a baby boy born at term after a normal pregnancy who grew without any abnormal signs or symptoms. for the first 7 months after birth, his serum tsh was abnormally high while his total serum t4, t3, and free t4, t3 were within normal limits, exept for slightly low free t4 level at 7 months. the raised serum tsh decreased spontaneously to within norma ... | 1979 | 533303 |
| evaluation of plasma hormone concentrations in relation to clinical staging in patients with prostatic cancer. british prostate study group. | plasma concentrations of testosterone, oestradiol-17 beta, luteinising hormone (lh), follicle stimulating hormone (fsh), prolactin and growth hormone (gh) were measured in patients with histologically proven prostatic cancer, before any form of therapy was given for this disease. patients were categorised according to uicc classification. no systemic change in the group means of any of these hormones was associated with the progression of the disease from the t0 to the t4 stage. when multivariat ... | 1979 | 533596 |
| cavernosography in the management of prostatic cancer. | cavernosograms were used in the investigation of 22 patients with prostatic cancer to determine the incidence of venous invasion. there were 21 patients with t3/t4 category tumours and one with a t2 tumour. all but one, a t3 tumour, had the radiological features of periprostatic venous malignant thrombosis. an attempt was made to correlate these findings with lymphography and tumour grade but no correlations could be made and the clinical relevance of these findings remains uncertain. | 1979 | 533598 |
| thyroid hormones and adipose tissue development. | the effect of thyroid hormones on the cellularity of the retroperitoneal adipose tissue (r.p.a.t.) was investigated in rats that were 3, 6 and 12 weeks old. two groups of rats were respectively made hypothyroid by the antithyroid compound propylthiouracil, or hyperthyroid by thyroxine. the number of adipocytes was less in the hypothyroid rats than in the controls; it was higher in the hyperthyroid rats without any concomitant increase in the weight of their r.p.a.t. moreover, there was no signif ... | 1979 | 533870 |
| reassembly of the bacteriophage t4 tail from the core-baseplate and the monomeric sheath protein p18: a co-operative association process. | 1979 | 533896 | |
| [studies on the measurement of serum thyroxine with "spac t4 ria kit" (author's transl)]. | 1979 | 533936 | |
| [treatment of ureteral obstructions due to prostatic carcinoma. prognostic value of response to medical treatment (author's transl)]. | a retrospective study concerning 146 patients with prostatic cancer showed that 30 of them (20 p.cent) presented ureteral obstacles at some time during the evolution of the disease. the majority of these cases were t3-t4 tumors. when a strickly medical approach allowed to reduce the obstruction, the 1 year survived rate was 71 p.cent. when surgery became necessary due to persistent renal insufficiency, in spite of medical treatment the 1 year survival rate was 15 p.cent. | 1979 | 534164 |
| hormonal factors in osteoporosis. | primary osteoporosis is a ubiquitous disease of unknown etiology. the condition undoubtedly has multiple causes and the metabolic pattern of bone loss may vary significantly from case to case. five hormones, pth, gonadal steroids, ct, t3 and t4, and glucocorticoids, and possibly a sixth, gh, have fundamental actions on bone metabolism and may therefore be causally involved in primary osteoporosis. a consideration of selected data on hormonal interactions culled from a much larger body of experim ... | 1979 | 535238 |
| effects of age on the metabolism of thyroid hormones by rat brain tissue in vitro. | using a newly-devised chromatographic method for the separation of the acetic and propionic analogues of triiodothyronine (t3) and thyroxine (t4), we studied the metabolism of radioactively labeled t3 and t4 in rat brain homogenates to determine whether the rates of metabolism and the types of products formed are influenced by the age of the animal. the separation of metabolites is achieved on silica gel h in a solvent system consisting of methylacetate-2.5% ammonia (w/v) (95:5 v/v). results cle ... | 1979 | 535533 |
| [thyroidal radioiodine uptake and t4 metabolism in nutritionally obese rats]. | 1979 | 535576 | |
| [t4 metabolism in age matched heavy and light rats with good and bad feed efficiency following high- or low-in-fat diet]. | rats, fed two diets (high or low in fat content), were at the and of the feeding-period separated in light and in heavy animal groups. the leaner rats from the diet group high in fat content show opposite to the heavier animals of this diet group significantly increased t4 distribution spaces, significantly shortened t4 half life time and lower feed efficiency. t4 serum values, absolute t4 degradation per day and body mass and free thyroxine index in these leaner rats also increased significantl ... | 1979 | 535577 |
| blood serum triiodothyronine (t3), thyroxine (t4) and thyroid stimulating hormone (tsh) concentrations in healthy children at the age of 1 and 2 years. | the physiological mean concentrations of t3, t4 an tsh in 150 healthy children aged from 1 month to 2 years of life decreased gradually with age. the statistically significant difference was observed only in t3 levels between the first and second year of life. the remaining parameters did not show statistically significant differences. | 1979 | 535584 |
| low muscle and liver glycogen contents in dogs treated with thyroid hormones. | muscle biopsies for glycogen determinations were taken from dogs before (controls) and after prolonged treatment with thyroid hormones (t4 or t3). the glycogen content in quadriceps femoris was measured before exercise, immediately after its cessation, and during 24h of post-exercise recovery. the effect of thyroxine treatment on the liver glycogen content both at rest and following physical effort was also studied. a marked decrease in the muscle glycogen content determined at rest was found bo ... | 1979 | 535882 |
| a study of age-dependent changes in thyroid function tests in adults. | total serum thyroxine (t4), triiodothyronine (t3), t3 resin uptake (t3u), thyrotrophin (tsh), and reverse t3 (rt3) were measured in 209 healthy adults 20--89 yr old. mean t4 values for men were stable throughout life, but in females under age 60, t4 values were significantly higher than in older women. values for t3u in males were significantly higher than in females throughout all decades, although females had a significant increase in t3u after age 60. tsh values increased significantly in fem ... | 1979 | 536771 |
| radioimmunoassay of free thyroxine with prebound anti-t4 microcapsules. | free thyroxine (ft4) may be one of the active throid hormones in contact with target end organs. it is unaffected by alterations in serum protein levels. in most cases, measurement of ft4 reflects an individual's true thyroid function or dysfunction. previous ft4 assay techniques have been difficult, tedious, indirect, and inaccurate. a rapid, simple, and accurate radioimmunoassay for ft4 has been developed using microencapsulated rabbit anti-t4 antiserum to which i-125 t4 tracer of high specifi ... | 1979 | 536842 |
| the effects of post-ganglionic axotomy on selective synaptic connexions in the superior cervical ganglion of the guinea-pig. | stimulation of preganglionic axons arising from different levels of the thoracic spinal cord causes different effects on end-organs supplied by the superior cervical ganglion (langley, 1892; nja & purves, 1977a; lichtman, purves & yip, 1979). for example, stimulation of the first thoracic ventral root (t1) causes pupillary dilatation and widening of the palpebral fissure; stimulation of t4, on the other hand, has little effect on the eye, even though axons arising from this level innervate about ... | 1979 | 536928 |
| three suppressor forms of bacteriophage t4 leucine transfer rna. | 1979 | 537091 | |
| the effect of rapeseed meal and methimazole on levels of plasma hormones in growing broiler cockerels. | the effects of feeding a heat treated rapeseed meal, which has goitrogenic properties, on the concentrations of plasma pituitary and thyroid gland hormones was investigated in broiler cockerels of between 3 and 10 weeks of age. for purposes of comparison, two other groups were included in the study; one was fed the goitrogen, methimazole, and the other a normal control diet. the hormones measured were thyroxine (t4), triiodothyronine (t3), growth hormone (gh), prolactin, and luteinizing hormone ... | 1979 | 537986 |
| the pathogenesis of propranolol-withdrawal syndrome in essential hypertension. | 1. in hypertension, the beta-adrenoreceptor-blocker-withdrawal syndrome comprises tachycardia, sweating, tremor and general malaise, symptoms resembling thyrotoxicosis. 2. the effect of abrupt cessation of propranolol on serum concentrations of thyroxine (t4) and triiodothyronine (t3) was therefore investigated in five patients with uncomplicated essential hypertension, treated with propranolol in doses from 160 to 480 mg/day. 3. four of the five patients developed one or more of the above-menti ... | 1979 | 540462 |
| changes in circulating l-thyroxine and l-triiodothyronine of the masu salmon, oncorhynchus masou accompaning the smoltification, measured by radioimmunoassay. | serum levels of l-thyroxine (t4) and l-triiodothyronine (t3) of the masu salmon, oncorhynchus masou, were measured by radioimmunoassay during the months from march to september. serum levels of t4 and t3 varied from 0.06 to 1.44 microgram and from 0.06 to 0.35 microgram per 100 ml serum respectively, although t4 content could not be detected in some specimens. t4 levels showed a seasonal fluctuation in which a higher value was observed in april when parr-smolt transformation was proceeding. t4 l ... | 1979 | 540573 |
| regulation of imm gene expression in bacteriophage t4-infected cells. | two polypeptides (imm-a and imm-b) which are not induced by an immunity mutant t4dimm2 but by a wild-type strain t4d were identified by sodium dodecyl sulphate (sds)-polyacrylamide gel electrophoresis. their mol. wt. were 77 000 and 45 000, respectively. these polypeptides exhibited a similar kinetic pattern of synthesis. within a few minutes p.i. the primary phage established the system that inhibited imm gene expression of superinfecting phage. this was shown by measuring both the phenotypic e ... | 1979 | 541664 |
| thyroid-hormone concentrations after radioiodine therapy for hyperthyroidism. | fourteen hyperthyroid patients (11 men, three women), ages 28-66, were followed with serial measurements of serum thyroid hormone levels for 1 mo after therapy with i-131. twelve patients had diffuse toxic goiters (25--70 g in size); two patients had multinodular glands (40--100 g). the patients were taking no antithyroid medications; ten patients were treated with propranolol. all patients received the equivalent of 5000 rad, except the two with multinodular glands, who received larger doses. t ... | 1979 | 541694 |
| [correlation between the plasma levels of t3, t4 and tsh in a normal population]. | 1979 | 542676 | |
| [effects of t3, t4 and methyltiouracile short-term treatments on plasma and liver lipid levels in rats (author's transl)]. | the effects of short-term administration of thyroid hormones (t3 and t4) and methyltiouracile (mtu) on liver and plasma lipid levels in female rats have been comparatively studied t3 increases the levels of all the studied liver lipids and decreases the plasma lipids. t4 produces smaller and even, in some cases (liver triglycerides and cholesterol esters), opposite effects. the administration of mtu produces, in general, opposite effects to t3 and t4. | 1979 | 542704 |
| thyroid function in breast cancer patients before and up to two years after mastectomy. | in 41 women newly diagnosed as having breast cancer the thyroid function was assessed by determination of the serum tsh, tririodothyronine (t3), reverse triiodothyronine (rt3), thyroxine (t4), t3-resin uptake and free t4-index. blood samples were drawn before the primary treatment and at follow-up after 7-28 months. there was no significant change in any of these variables during the period of observation. nor was there any difference between the values of the patients who developed recurrent di ... | 1979 | 543051 |
| [iodoamino acid distribution and weight of the thyroid gland, t4 serum level and t4 metabolism in relation to diet, body fat content and age of rats]. | rats were rendered obese by feeding them a fatty diet (hfd, fat: 50% of weight). at the end of the experimental period the animals were divided, also the control rats, which were fed a low-fat diet (lfd, fat: 3% of weight), in light and heavy weight groups. the heavy and obese hfd groups showed, unlike the light lfd-animals, equal absolute but significantly lower relative thyroidal weights. the absolute thyroidal weights of light and heavy animal groups, which received in each case the same diet ... | 1979 | 543366 |
| destruction of bacterial viruses in serum by heat and radiation under conditions that sustain the ability of serum to support growth of cells in suspended culture. | methods for inactivating bacterial viruses in serum were developed through the use of heat and ionizing radiation, and the effects of these treatments on the growth rates of cultured cells were tested. viruses chosen for this study were the radiation-resistant bacteriphage f2 and heat-resistant phage t4. the viabilities of these phages were reduced more than 2 and 4 orders of magnitude, respectively, by a treatment at 60 degrees c for 30 min followed by 420 krads of ionizing radiation. simultane ... | 1979 | 544633 |
| [variations in thyroid hormone levels concomitant with age in a normal population. ii: levels of t4 in plasma]. | 1979 | 545468 | |
| [relative variation of t3, t4 and tsh plasma levels in patients with primary hypothyroidism]. | 1979 | 545481 | |
| synthesis of oligonucleotides with t4 rna ligase. | 1979 | 547234 | |
| antarctic wintering--over, suggestion and transient olfactory stimulation: eeg evoked potential and electrodermal responses. | eeg evoked potential and electrodermal responses to real and suggested olfactory stimulation were recorded on a team of nine men who wintered-over at scott base, antarctica. multi-variate analysis of variance findings indicated some consistent trends despite adverse conditions and marked inter-individual differences. consistent with studies of secondary afferentation olfaction-related eegs were evidenced in the occipital area (o1 and o2) as well as the temporal area (t3 and t4). skin conductance ... | 1979 | 548128 |
| [effect of surgical stress on tsh and on the extra-thyroid metabolism of t4 (preliminary experiment)]. | the effect of the surgery on the tsh and on the extra thyroid t4 metabolism was studied in thirty euthyroid patients. the tsh showed a light increase thirty minutes after the skin cut. there were no remarkable changes of t4 serum levels, while the serum triiodothyronine concentration fell during and after the operation, with a concomitant rise in reverse triiodothyronine. | 1979 | 552848 |
| [correlation between red cell 2,3-dpg and serum levels of thyroid hormones in newborn infants]. | the correlation between red cell 2,3-dpg and serum levels of thyroid hormones (t4 and t3) has been evaluated in full-term newborns, 1 to 4 days old. a direct effect of thyroxine (t4) on the post-natal increase of red cell 2,3-dpg was excluded because no significant correlation was found between the rise of 2,3-dpg concentration and serum t4 level. | 1979 | 553555 |
| [thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient nath diet]. | the administration of drinking-water, added with licl (20mg li+/l) to rats fed on "atherogenic" diet without cholesterol (casein 20% hydrogenated coconut oil 25%, sucrose 49.1%) for 90 days, elicits an expressive diminution of haematic lipids (triglycerides, free fatty acids, total cholesterol) and hepatic cholesterol. the serum dosages of thyroid hormones t3 and t4 show that the li+ concentration used in the experiment do not inhibit the glandular functions. | 1979 | 553577 |
| [metabolism of thyroxine in acute viral hepatitis]. | aim of this report was to define the correlation between hepatic acute damage and thyroxine metabolism. we have studied plasma levels of t4, t3, rt3 and tsh in 18 adult male subjects with acute viral hepatitis. no significant variation of t4, t3 and tsh plasma levels was found in different phases of disease. however, plasma rt3 levels were clearly elevated in 72% of patients in the first 7 days (mean 440 pg/ml vs 198 pg/ml of normal controls) and in 17% of cases in the second 10 days of disease ... | 1979 | 553591 |
| ["low triiodothyronine (t3) syndrome": "thyroxine (t4) euthyroidism" evidence (author's transl)]. | as first described in serious systemic illnesses isolated decreased t3 plasma concentration was related to impaired peripheral conversion of t4, to t3 with preferential production of reverse t3 (rt3). a "low t3 syndrome" was seen in 47 out of 109 patients with extra-thyroidal diseases. metabolic state, tsh and tsh responses to trh were normal despite of low t3 concentration. euthyroidism seems mainly due to t4 itself in these patients. | 1979 | 554102 |
| influence of ethanol on thyroxine accumulation in the hypothalamus, pituitary gland and cerebrospinal fluid in the newborn rabbit. | the effect of ethanol on thyroxine (t4) accumulation in the hypothalamus (h), pituitary gland (p) and cerebrospinal fluid (csf) has been investigated in 1-15-day-old rabbits. it has been found that h or csf serum ratios decreased with age by about 2 in the course of 13 postnatal days. stable t4 resulted in an increase of 125 i-t4 in h, p and csf. ethanol per se caused an increase in transfer and accumulation of radiothyroxine or made the changes after loading animals with carrier t4 more pronoun ... | 1979 | 571351 |
| sinemet and thyroid function in parkinson disease. | patients on chronic carbidopa-levodopa (sinemet) therapy underwent thyroid function testing that included measurement of serum thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), t3 uptake (t3u), free t4 index (ft4i), and free t3 index (ft3i). the subjects were studied both in a random sampling and in a controlled manner, fasting and 2 hours after receiving the drug. all subjects were euthyroid by testing, and there was no significant difference in thyroid hormone levels of patients and co ... | 1979 | 572939 |
| prolactin, lh, tsh, t3 and t4 in patients with urogenital carcinomas. | serum level of peptide hormones lh, fsh, tsh and prolactin have been measured in patients with urogenital tumor. in this randomized study we found a frequent elevation of tsh and prolactin, which did not correlate. increased serum level of tsh was confirmed to be without any elevation of serum t3 and t4. in some of these patients ectopic production of peptides may account for this abnormality. systemic change of peptides in elderly patients, however, must be taken into consideration as well. | 1979 | 573007 |
| diurnal rhythm of pituitary-thyroid axis in male rats and the effect of adrenalectomy. | levels of tsh, thyroxine (t4) and triiodothyronine (t3) were measured by radioimmunoassay in plasma (tsh, t4, t3) and pituitary (tsh) of 60-day old male long-evans rats. definite diurnal rhythms were demonstrated in pituitary tsh, plasma tsh and t3 in intact rats, evidenced by the statistically significant differences between zenith and nadir for pituitary tsh, plasma tsh and t3. the zenith value of pituitary tsh and the nadir values of plasma tsh, t4 and t3 were observed at the same time (2400 ... | 1979 | 573683 |
| plasma thyroid hormone and glucocorticosteroid concentrations in the male rat following prolonged exposure to stress. | exposure of male csf rats to a signalled unpredictable 60-day stress regimen induced a significant elevation in circulating triiodothyronine (t3) concentration above the control for the first 20 days of stress before the rate of secretion returned to normal. on the other hand, circulating thyroxine (t4) concentration fell significantly below the control value for the first 5 days of stress before the normal rate of secretion was reached in 10 days. a histological study of the thyroid gland revea ... | 1979 | 573997 |
| effect of chronic metoclopramide therapy on serum pituitary hormone concentrations. | the effect of chronic (3--9 months) therapy with metoclopramide on serum levels of pituitary and thyroid hormones was studied in 4 males and 1 female. the mean serum prolactin concentration during metoclopramide therapy was significantly higher than after discontinuation of metoclopramide. serum prolactin concentrations increased acutely after each dose of metoclopramide. serum prolactin concentrations increased acutely after each dose of metoclopramide, and gradually returned to normal by 6--12 ... | 1979 | 574121 |
| effect of a single dose of glucocorticoid on the diurnal variations of tsh, thyroxine, 3,5,3'-triiodothyronine, 3,3'5'-triiodothyronine and cortisol in normal men. | plasma thyrotropin (tsh) and cortisol concentrations were suppressed immediately after an intravenous bolus dose of 8 mg betamethasone in 6 male subjects. the circadian variations of these hormones disappeared for 40 hr (tsh) and 44 hr (cortisol). plasma thyroxine (t4), 3, 5, 3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3) levels did not show diurnal variations before betamethasone administration. plasma t3 levels decreased to 66% of the basal levels 20 hr after batamethasone adm ... | 1979 | 575506 |
| [comparative examination of endocrine ophthalmopathy by means of ultrasonography, computerized tomography and fish bioassay]. | in 35 patients with graves' ophthalmopathy (go) thyroid function was tested by t3-ria, t4-ria, tbi, trh-test, thyroid scanning, and determination of thyroid autoantibodies. additional ultrasonography (a-scan), computed tomography (ct) of the orbit, and the determination of an exophthalmogenic serum activity in fish bioassay was performed. typical alterations for go were observed in 26 cases with ultrasonography. ct showed an enlargement of medial and/or lateral rectus muscles in 24 of 33 patient ... | 1979 | 583057 |
| studies on the action of pesticides upon the endocrines using in vitro human thyroid cells culture and in vivo animal models. i. herbicides--aminotriasole (amitrol) and atrazine. | the action of aminotriasole (amitrol) and atrazine in doses of 0.001--1 mg and 0.0001--.01 mg/1.5 ml medium, respectively, upon cell cultures of human thyroid was studied in order to find out their influence on cell multiplication, proteic synthesis, enzymatic activity of thyroid cells, and hormonal synthesis. the results varied according to the dose utilized and the type of thyroid cell studied. the acute experiment carried out on rats treated 15 days with 500 ppm amitol and 50 ppm atrazine rev ... | 1979 | 583081 |
| high-frequency generalised transduction by bacteriophage t4. | 1979 | 15305587 | |
| procedure for a normalised thyroxine determination in small sephadex columns. | a rapid simple test for measuring normalised serum thyroxine is described in detail, using small sephadex columns. a small portion of test serum is reintroduced into the test system at the competitive binding stage, so that corrected t4 values are obtained when the concentrations of thyroxine binding globulin are variable. only 125 microliter serum is required for the whole test. values obtained by the present method correlated well with the product of thyroxine concentration and radioactive t3 ... | 1978 | 417144 |
| separation of very large dna molecules by gel electrophoresis. | very large dna molecules were separated by electrophoresis in horizontal slab gels of dilute agarose. conditions of electrophoresis were developed using intact dna molecules from the bacterial viruses lambda, t4 and g. their dnas have molecular weights (m) of 32 million, 120 million, and 500 million, respectively. several electrophoresis conditions were found which give sufficiently high mobilities and large differences that these dnas are separated in a short time. electrophoresis in 0.1% agaro ... | 1978 | 417296 |
| dose response in radiotherapy for glottic carcinoma. | all consecutive patients with glottic squamous cell carcinoma treated primarily by radiotherapy from 1965 through 1974 have been analyzed to reveal response of the primary tumor in relation to the dose. this study appears to indicate presence of dose response for all stages of the primary lesions (t) of the glottic carcinoma except for the smallest ones namely tis, t1a and t1b. the total number of advanced tumors is small and selected. but they tend to indicate presence of dose response. out of ... | 1978 | 417795 |
| lowering of serum 3,3',5-triiodothyronine thyroxine ratio in patients with myocardial infarction; relationship with extent of tissue injury. | serial measurements of haematocrit (ht), plasma thyroxine (t4), triiodothyronine (t3) and alpha-hydroxybutyrate dehydroxygenase (alpha-hbdh) were performed in patients following myocardial infarction (mi). infarct size was estimated by mathematical analysis of the change in plasma alpha-hbdh activity with time. after an initial small increase ht decreased 12% until day 9 and remained constant thereafter. serum t4 did not change during the entire study. serum t3 decreased to 66% at day 9 and then ... | 1978 | 417942 |
| use of melatonin and synthetic trh to determine site of pineal inhibition of tsh secretion. | an experiment was performed on 21-day-old male rats to determine the combined effects of pinealectomy, constant light and darkness, and intraperitoneal (i.p.) thyrotropin-releasing hormone (trh) on pituitary and plasma radioimmunoassayable thyrotropin (tsh), serum thyroxine (t4), and pituitary, thyroid and body weights at the age of 25 days. in saline-treated rats, pinealectomy or constant illumination decreased pituitary tsh and increased plasma tsh and serum t4. constant darkness with an intac ... | 1978 | 418360 |
| studies on the primary and secondary structure of potato spindle tuber viroid: products of digestion with ribonuclease a and ribonuclease t1, and modification with bisulfite. | potato spindle tuber viroid (pstv), a small infectios rna, has been completely digested with rnase t1 and rnase a, and the resulting oligonucleotides have been sequenced using 5'-terminal 32p-labelling with gamma-32p atp and t4 polynucleotide kinase, fingerprinting and controlled nuclease p1 digestion. modified nucleotides have not been detected in 5'-positions of these oligonucleotides. pstv consists of about 359 nucleotides and contains a remarkable stretch of 18 purines, mainly adenosines; th ... | 1978 | 418383 |
| effect of oral thyrotropin releasing hormone on serum prolactin, thyrotropin and total thyroxine levels in postpartum women. | a study was designed to investigate the effects of oral administration of thyrotropin releasing hormone (trh) on prolactin levels and on thyroid function during the early puerperium. eight lactating mothers took a single dose of oral trh (40 mg) while eight other volunteers had a placebo treatment. serial serum samples taken before and after treatment were assayed for prolactin, thyrotropin (tsh) and total thyroxine (t4) by using specific radioimmunoassays. there was approximately twofold increa ... | 1978 | 418585 |
| [study of the thyroid function by the i-m trh test (2 mg) (author's transl)]. | the responses of tsh, t3 and t4 to intramuscular administration of 2 mg of trh were compared in the same subjects to those observed after intravenous injection of 200 microgram of trh. in 12 normal subjects the tsh and t3 peaks were significantly higher after intramuscular injection. there was no difference in t4 levels. in 15 patients: 5 toxic adenomas after surgery and 10 graves' disease after treatment the results were comparable for tsh and t3 by the two routes. | 1978 | 418731 |
| [chronologic study of free t3 and t4, of responses to trh and of the suppression test during treatment of basedow's disease]. | 32 patients with graves' disease were investigated before treatment, during atd therapy and after recovery with a normal t3 suppression test. before treatment, trh response was negative with elevated values of plasma tt4, aft4, tt3 and aft3. the 3d, 6 - 9 and 12-18 months and after recovery, several patients remained unresponders to trh despite normal aft4 and aft3 in serum. in an opposite way some patients were responders, 1 month after atd withdrawal, at the 6-9 month, with elevated values of ... | 1978 | 418732 |
| [alterations in thyroid hormones and thyrotropin response to trh in cirrhotic patients with or without hyperammonemia (author's transl)]. | serum concentrations of thyroid hormones and tsh response to trh are studied in normal controls and in patients with liver cirrhosis. t3 levels are significantly diminished in the cirrhotic group while the mean total t4 concentration, the basal tsh and the magnitude of the peak response to trh are similar in cirrhotic and control patients. however when the cirrhotic patients are separated in two groups according to the level of arterial ammonemia, it appears that the group with hyperammonemia (n ... | 1978 | 418733 |
| [serum t4 determination with a double-antibody technic--studies of thyroxine(t4) "eiken kit"]. | 1978 | 564763 | |
| serum t4 and t3 in active and torpid ground squirrels, spermophilus richardsoni. | 1978 | 566236 | |
| [sex hormone binding globulin (shbg), a new metabolic in vitro thyroid function test]. | shbg (sex hormone binding globulin) is a carrier protein for the sex hormones testosterone and estradiol with a molecular weight of about 95000 dalton. it can be used as a metabolic test of thyroid function. shbg was measured by the adsorption method of mickelson and petra; the shbg contained in serum is incubated with 3h-5alpha-dihydrotestosterone and adsorbed to a cellulose filter. thirty-eight female patients with hyperthyroidism before treatment had markedly elevated levels of shbg (x +/- sd ... | 1978 | 568820 |