Publications

immunoassay for serum thyroxine monitored by chemiluminescence.	an immunoassay for thyroxine (t4) monitored by chemiluminescence was evaluated with clinical serums. a thyroxine-label conjugate (t4-l) and serum samples were applied sequentially to alkaline sephadex g-25 columns which adsorbed the thyroxine species. other serum components and potential interferents were washed from the column with barbital buffer. subsequently addition of antibody initiated the binding reaction. after 1 h incubation, the antibody was eluted from the column with a barbital buff ...	1979	762437
adolescent secondary amenorrhea: association with hypothalamic hypothyroidism.	in adolescent girls, secondary amenorrhea can result from a variety of physiologic and psychologic disturbances. previous reports associating amenorrhea and primary hypothyroidism have not distinguished between the alternative etiologic roles of thyroxine deficiency and hyperprolactinemia. we have evaluated two girls with secondary amenorrhea who had clinical and chemical evidence of hypothyroidism. both had low basal t4 values (0.8 and 3.2 microgram/dl), calculated free t4 (0.1 and 0.7 ng/dl), ...	1979	762630
changes in thyroid-stimulating immunoglobulins during antithyroid therapy.	thyroid-stimulating immunoglobulin (tsi) activity was measured by radioreceptor assay in sera from patients with graves' disease, hashimoto's thyroiditis, and thyroid cancer. in untreated graves' disease (47 cases), tsi index was significantly lower [76.7 +/- 1.4 (se)] than the average of a normal control group (30 cases; 94.4 +/- 1.9). in untreated hashimoto's thyroiditis (25 cases), it was also significantly lower (83.0 +/- 2.4). in patients with thyroid cancer (19 cases), there was no signifi ...	1979	581875
[radiotherapy with 131j and 125j of basedow's disease. indications and results relative to the incidence of post-actinic hypothyroidism].	the indications for radioisotope management in basedow's disease and the complications involved are explained. particular reference is made to the possibility of early or late hypothyroidism when 131i and 125i are employed for this purpose. the physiopathogenetic bases for this are examined in relation to dosage and early diagnosis. results obtained with small doses (fractionated in some cases) of these isotopes in 126 patients with thyrotoxicosis. one-year and later follow-up was directed to th ...	1979	581903
propranolol in thyrotoxicosis: ii. serum thyroid hormone concentrations during subtotal thyroidectomy.	propranolol alone was used to prepare 20 thyrotoxic patients, 19 women and 1 man, for subtotal thyroidectomy. serum thyroxine (t4) and triiodothyronine (t3) concentrations were measured immediately before, at several stages during and after the surgical procedure. as judged primarily by the cardiovascular response, an average of 80 mg (range 40 to 120 mg) of propranolol qid for 8 days (range 3 to 18 days) was required to prepare the patients. during the various stages of surgical removal there w ...	1979	582022
alkaline phosphatase isoenzyme patterns in hyperthyroidism.	fifteen of 36 hyperthyroid patients had elevation in serum alkaline phosphatase activity. there was no difference in mean thyroxine (t4), triiodothyronine (t3), age, or duration of illness between the groups with high alkaline phosphatase and normal alkaline phosphatase levels. after treatment, serum alkaline phosphatase levels rose as t4 levels declined; at 3 months, the mean serum alkaline phosphatase value rose from 7.1 bodansky units to 10.3 bodansky units (p less than 0.005), while the mean ...	1979	582089
plasma dopamine-beta-hydroxylase activity and thyroid suppressibility in graves' disease.	plasma dopamine-beta-hydroxylase (dbh) activity, serum t4, t3, t3u, and the 24-hr thyroid uptake before triiodothyronine suppression testing were studied in 34 patients with treated graves' disease. although all of them were in the euthyroid state, there was a statistically significant difference in presuppression plasma dbh activity between those patients who showed suppression of their rai uptake with triidothyronine and those who did not. this suggests a relationship between plasma dbh activi ...	1979	582284
myasthenia gravis, pernicious anemia, and hashimoto's thyroiditis.	a 68-year-old woman with clinical, electromyographic, and pharmacologic evidence of myasthenia gravis experienced increasing proximal and bulbar muscular weakness. the diagnosis of pernicious anemia was established by typical abnormalities in the peripheral blood and bone marrow aspirate, the serum b12 level, by results of the schilling test, and by the presence of serum parietal cell antibody. the diagnosis of hashimoto's thyroiditis was established by the presence of diffuse thyroid enlargemen ...	1979	582504
[new aspects in the treatment of elderly people with carcinoma of the urinary bladder (author's transl)].	50% of the patients with carcinoma of the bladder are older than 70 years. during the first examination a deep muscle invasion was found in about 60%. (stages t3/t4. this situation makes forced surgical intervention in most cases impossible (e.g. radical cystectomy and segmental resection), therefore the transuretheral resection has to be the leading therapeutical procedure. during the past 10 years 80% of the bladder cancer patients were treated by tur most ofter followed by external irradiatio ...	1979	33571
attachment of bacteria to exfoliated cells from the urogenital tract.	to establish urogenital infections, organisms must adhere to the mucosal lining. a differential adherence capacity among various bacterial species was observed when exfoliated urethral and urothelial cells were tested in an in vitro system. no difference in the adherence capacity of a particular species was observed when tested with exfoliated cells obtained from voided urine from different healthy individuals of the same sex. escherichia coli harvested directly from urine specimens of patients ...	1979	34577
[role of proton motive force in the infection of e. coli k-12 cells by bacteriophage t4].	it was shown that infection of e. coli cells by phage t4 is suppressed, when the cells are treated by oxidative phosphorylation uncouplers. the inhibiting effects of the uncouplers manifest themselves at the stage of phage dna entry into the cells. study of the e. coli cells devoid of their h+-atpase activity due to mutation showed that the infection is suppressed by a switch-off of the respiratory chain, the only generator of the proton motive force (pmf) in mutated cells. infection of the e. c ...	1979	35241
the effect of oral thyrotropin-releasing hormone on thyroid function and the composition of breast milk in puerperal women.	to determine the effect of oral administration of thyrotropin-releasing hormone (trh) on the thyroid function and on the composition of breast milk in the early puerperium, six lactating women were treated with a single dose of 40 mg of synthetic trh and six women were treated with placebo. serial serum samples taken before and between one and 25 hours after trh administration were assayed with specific radioimmunoassays for thyrotropin (tsh), triiodothyronine (t3) and total thyroxine (t4). milk ...	1979	35406
tyrosine hydroxylase and the conversion of l-thyroxine into 3',3,5-triiodo-l-thyronone in the rat.	we have studied the effects of alpha-methyl-p-tyrosine (alpha-mpt), an inhibitor of tyrosine hydroxylase, on the in vivo conversion of l-t4 (t4) to 3',3,5-triiodo-l-thyronine (t3), and on the biological effectiveness of t4. thyroidectomized rats were used and were injected daily with t4 maintenance doses. three different types of experiments were carred out. the first involved isotopic equilibration with 125i-labeled t4 and measurement of urinary 125i excretion. the second series involved the in ...	1979	36273
observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting.	studies were performed to explore the mechanism underlying the impaired generation of 125-i-3,5,3'-triiodothyronine (t3) from 125i-thyroxine (t4) (t3-neogenesis)) in preparations of liver from rats fasted for 48 h and the prevention of this effect by the feeding of glucose. t3-neogenesis in livers from fasted animals and those fed chow or glucose was assessed in various mixtures of crude microsomal fractions with either buffer or cytosols. t3-neogenesis was mediated by an enzyme present in the m ...	1979	36408
attachment of neisseria gonorrhoeae to human sperm. microscopical study of trypsin and iron.	pilated neisseria gonorrhoeae of colony type 1 (t1) and non-pilated bacteria of colony type 4 (t4) were observed by transmission (tem) and scanning electron microscopy (sem). no pili were observed on t4 gonogocci, but two types of pili--straight, type a, and bent, type b--were seen on t1 by tem. when incubated with human sperum and examined by either tem or sem, t1 gonococci were seen to attach by individual pili, by several pili wound together as a rope, or by direct contact. gonococci from t4 ...	1979	39583
the relative merits of polyethyleneglycol as a separating agent in the radioimmunoassay of thyroid hormones.	polyethyleneglycol (peg) has been recommended as a separating agent in the assay of some peptide hormones (desbuquois, b. and aurbach, g.d. (1971) j. clin. endocrinol. 33, 732) and several substances of low molecular weight (ratcliffe, j.g. (1974) br. med. bull. 30, 32). in the present study the peg-separation technique has been modified and adapted for the assay of thyroid hormones. separation with peg has the advantage of being cheap, rapid and relatively non-susceptible to disturbances as com ...	1979	39694
iodoamino acid synthesis in thyroid lobes in vitro with excellent yield of iodothyronines.	thyroid lobes of male sprague-dawley rats on an iodine-sufficient diet were incubated in our improved in vitro system with 0.01 microm 127i and 5mu/ml of bovine tsh. thyroidal 131i-uptake and the relative incorporation of iodine into iodothyronines increased with time. the average yield of each iodoamino acid after 8 h of incubation was: monoiodotyrosine 28.0%, diiodotyrosine 46.5%, triiodothyronine 1.9% and thyroxine 13.9%, which showed a striking resemblance to the values obtained in vivo. the ...	1979	40373
[the neuroendocrine response to alfatesine or ethrane anesthesia in humans].	the description of neuro-endocrine effects due to surgical stress and certain anaesthetic products led the authors to look for the action of alfadione and enflurane on the hypothalamic-hypophyseal-thyroidian-adrenal axis. taking 20 subjects who were divided into three groups of 10, the authors measured the plasma levels of t3, t4, tsh, cortisol and acth during anaesthesia with alfadione (without surgery). this was group i. group ii were patients during surgery under alfadione. group iii was duri ...	1979	40485
plasma triiodothyronines in fetal sheep: effects of illness and thyroidectomy.	plasma 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine concentrations were measured in fetal sheep prior to death in utero and after thyroidectomy. in six fetal sheep who subsequently died in utero, plasma rt3 concentrations were elevated in all for 2 to 13 days prior to death. there were no consistent changes in plasma t4 concentrations. in two thyroidectomized fetal sheep, plasma t4 and rt3 concentrations fell to low levels. plasma t3 concentrations remained low and there was no incr ...	1979	40859
requirement for membrane potential in injection of phage t4 dna.	the first stages of infection by phage t4 may be divided into energy-dependent and energy-independent processes. irreversible adsorption, unplugging, and initial exposure of the dna terminus may occur at 4 degrees c, or at 37 degrees c in bacteria whose energy-yielding metabolism has been poisoned. dna injection into the cytoplasm needs higher temperatures and energy from the host cell. the nature of this energy requirements was deduced from the use of metabolic inhibitors. our results show that ...	1979	41245
control of cfuc proliferation by selective endogenous inhibitors.	the susceptibility of mouse bone marrow colony forming cells (cfuc) to three different types of proliferation inhibitors in capillary semisolid agar gel was studied. gi-3, a target specific peptide containing granulocyte fraction, t4-1, an oligospecific thymic factor of proteid nature, and the alkylating cytostatics dianhydrogalactitol (dad) inhibit myeloid colony formation as a function of concentration. the respective med values amount to 8, 10, and 0.002 microgram/ml. when compared with this ...	1979	42209
ph modification of the effects of detergents on the stability of enteric viruses.	the effect of detergents on the stability of enteric viruses was found to be highly dependent on ph. this was demonstrated primarily with two ionic detergents, sodium dodecyl sulfate (an anionic detergent) and dodecyltrimethylammonium chloride (a cationic detergent). both detergents were shown to be potent virucidal agents for reovirus, but the effects of sodium dodecyl sulfate were minimal near neutrality and much more pronounced at low than at high ph values. dodecyltrimethylammonium chloride ...	1979	42351
stability of phage t4 lysozymes. ii. unfolding with guanidinium chloride.	the denaturation by guanidinium chloride of three phage lysozymes (wild type and two mutants) was investigated. the study of solvent denaturation permitted the investigation of the relative stabilities of the proteins at neutral ph, in contrast to thermal denaturation studies reported earlier which could only be performed in acid ph. the results were interpreted assuming that the free energy of solution of proteins is a linear function of denaturant concentration. using standard thermodynamic fo ...	1979	42444
free t4, free t3 and free reverse t3 in dialysates of serum. the influence of electrolytes and ph with special reference to the physiological range.	the influence of electrolyte composition and ph of buffer on free t4, free rt3, and free t3 concentrations in serum dialysates has been evaluated, using an equilibrium dialysis method with subsequent direct radioimmunoassay estimations of the dialysate. cl-, hco3- and h+ were found to be the important ions which at concentrations similar to those occurring in vivo decreased the protein binding of all three hormones in serum, t3 being much less sensitive to these changes than t4 and rt3. the poss ...	1979	42963
effect of beta-blocking agents in hyperthyroidism.	propranolol modifies peripheral thyroxine metabolism, in opposition to the beta blocking agent gyki 41099 which has no such effect. both beta-receptor blockers produce a significant fall in the serum camp level of hyperthyroid subjects. it is suggested that the beneficial effect of the beta-blocking agents in hyperthyroidism is partly due to their depressive effect on camp production. as far as the action of propranolol is concerned, it may well involve an additional effect on t4 metabolism.	1979	45285
physical mapping of the restriction fragments obtained from bacteriophage t4 dc-dna with the restriction endonucleases smai, kpni and bglii.	the cytosine-containing dna of a mutant of bacteriophage t4 was digested with restriction endonucleases smai, kpni and bglii producing 5, 7 and 13 fragments respectively. complete physical maps of the t4 genome were constructed with the enzymes smai and kpni and an almost complete map with the enzyme bglii.	1979	45792
establishment of specific antibody producing human lines by antigen preselection and epstein-barr virus (ebv)-transformation.	specific antibody producing human cell lines were established by preselecting antigen binding b-lymphocytes and subsequently transforming ("immortalizing") them with epstein-barr virus (ebv). nnp-binding b-cells were isolated from the blood of three donors with high anti-nnp titers. ebv-transformation led to polyclonal cell lines that had 15-18% nnp receptor positive cells. a similar fraction of the cells produced nnp-specific plaques in the cunningham-szenberg assay. unconcentrated culture medi ...	1979	95800
t3/t4 ratio in thyroid disease.		1979	84114
raised total thyroxine and free thyroxine index but normal free thyroxine. a serum abnormality due to inherited increased affinity of iodothyronines for serum binding protein.	2 people from different families had high levels of serum-thyroxine (t4) and a high free t4 (ft4) index but a normal serum triiodothyronine (t3) and serum-reverse-t3 (rt3). the abnormal serum thyroid hormone profile appeared to be inherited in an autosomal dominant manner. serum-ft4 in affected relatives was normal. the increases in serum-t4 and ft4 index are explained on the basis of an observed increase in affinity of t4 for thyroxine-binding globulin, thyroxine-binding prealbumin, and albumin ...	1979	85873
euthyroid high total t4, normal t3 syndrome.		1979	86912
euthyroid high total t4, normal t3 syndrome.		1979	86913
[fundamental studies of t4 value by tetra tab kit (author's transl)].		1979	87004
bleomycin fragmentation of duplex dna occurs as staggered single-strand scissions.	electron microscopy of purified full-length linear duplex molecules produced by bleomycin reaction with pm2 dna revealed low frequencies of closed circular duplex molecules as well as linear duplex molecules with opposed ends (cyclized molecules which have dissociated to yield a gap between the termini). the occurrence of these latter forms indicates that double-strand scissions produced by bleomycin reaction consist of two single-strand scissions which are physically staggered on the complement ...	1979	93065
[short-term use of lithium carbonate in the treatment of thyrotoxicosis].	the examinations were performed on 3 groups of altogether 65 persons with thyreotoxicosis, the cause of which was either basedow's disease or struma nodosa. the first group received metizol (thiamazol) in a daily dosage of 60 mg, the second group lithium carbonate (1.0 up to 1.5 g/a day), the third group metizol together with lithium carbonate. the groups were of the same value, concerning the degree of the symptoms of hyperthyroidism. the examinations showed that when lithium carbonate is used ...	1979	93353
function of individual e. coli 30 s ribosomal proteins as determined by in situ immunospecific neutralization: a tentative classification.	the accessibility of each 30s subunit protein to their cognate antibodies (igg or fabs) having been previously well established, the effect of their in situ specific neutralization by monovalent igg fragments (fabi) are reported for five reactions: 1) t4 and r17 rna directed protein synthesis: 2) polyphenylalanine synthesis: 3) enzymatic phe-trna binding in the presence of 30s + 50w subunits: 4) fmet-trnaf binding to the 30s subunit in the presence of initiation factors if1, if2, if3; 5) couplin ...	1979	93493
structure of the rna portion of the rna-linked dna pieces in bacteriophage t4-infected escherichia coli cells.		1979	94107
uptake of thallium-201 in enlarged thyroid glands: concise communication.	we have investigated the thyroid uptake of tl-201 in 37 patients with various types of goiter, and in six with normal thyroids. significant thallium uptake was found in all cases in which there was thyroid enlargement, including graves' disease, toxic thyroid nodule, primary hypothyroidism, simple goiter, hashimoto's disease, thyroid carcinoma, and thyroid adenoma. if goiter was absent, however, there was no demonstrable uptake--e.g., in secondary hypothyroidism, subacute thyroiditis, and the no ...	1979	94354
[changes of the plasmatic correlations between t3, t4 and tsh in patients with hyperthroidism before and after treatment with synthetic antithyroid drugs].		1979	94678
thyroid activity in a hypometabolic primate, the owl monkey (aotus trivirgatus).	serum levels of triiodothyronine (t3) and tetraiodothyronine (t4) were significantly lower in owl monkeys than in long-tailed macaques. these observations were considered to be consistent with the lower metabolic rate of the owl monkey. however, the absence of a significant difference in the levels of thyroid stimulating hormone (tsh) between the two species suggested a lower thyroid sensitivity to tsh in the owl monkeys. there was an inverse relation between levels of t3 and tsh in the owl monk ...	1979	94828
[inhibition of rna synthesis in vitro by antibodies against mononucleotides].	antibodies against purine nucleotides were obtained from rabbits immunized with conjugates of bovine serum albumine with amp or gmp. the antibodies purified by affinity chromatography on nucleoside monophosphate-human serum albumine-sepharose columns inhibited rna synthesis on native t4 phage dna by e. coli rna polymerase. the inhibition of transcription was due mainly to inhibition of the initiation stage of rna synthesis.	1979	94937
[differences in sensitivity of t3, t7, t4 and lambda phages to bleomycin and phleomycin].	in contrast to phage lambda the phages t3, t7 and t4 are not inhibited by as much as 150 microgram bleomycin/ml, while the chemically related antibiotic phleomycin increasingly inhibits the propagation of the phages in the order t4-t3-lambda. 20 microgram phleomycin/ml inhibit t3 by 95%. the resistance against bleomycin is surprising, because 10 microgram bm/ml block completely the colony-forming capacity of the host bacterium. the drug resistance of the phage growth correlates with the weak dec ...	1979	94958
euthyroid high total t4, normal t3 syndrome.		1979	87650
short-term triiodothyronine in prevention of temporary hypothyroidism after subtotal thyroidectomy for graves' disease.	to determine whether short-term thyroid hormone replacement prevents or merely delays temporary hypothyroidism after surgery for graves' disease, serum t3, thyroid-stimulating hormone, and t4 were measured every 2 months for 18 months in two groups of graves' disease patients who had had subtotal thyroidectomy. group i (18 patients) were given t3 20 microgram four times daily from surgery through the twelfth postoperative month. group ii (18 patients) received no treatment. hypothyroidism occurr ...	1979	87965
spinal ganglion cells innervating the stomach of the rat as demonstrated by somatopetal transport of horseradish peroxidase (hrp).	spinal ganglion cells innervating the stomach of the rat were demonstrated using the somatopetal horseradish peroxidase (hrp) transport technique. after injection of the tracer into the anterior wall of the stomach, labelled neurons were observed bilaterally within spinal ganglia t4--l1. they were most numerous in ganglia t8--t10. no clear evidence of somatotopic organization of the labelled cells was found. most of the cells measured 35--40 micrometer in diameter. there was a striking paucity o ...	1979	88192
the influence of non-steroidal anti-inflammatory and antithyroid agents on myeloperoxidase-catalysed activities of human leucocytes.	viable leucocytes obtained fresh from normal human subjects were shown to be able to catalyse the in vitro iodination of bovine serum albumin (bsa) in a h2o2-generating system. the rate and degree of iodination were greatly improved by sonication of the cells. a balanced salt solution was a more favourable medium than phosphate buffer for the myeloperoxidase (mpo)-catalysed iodination of whole cells and sonicated cells. reactions known to be catalysed by other peroxidases (e.g. thyroid peroxidas ...	1979	89704
[investigation of serological features and molecular heterogeneity of virion proteins of morphologically related phages].	some interaction process peculiarites of morphologically related phate t4, ddvi and fi1 with the corresponding antiphageous sera in cross reactions of neutralisation have been investigated. close serological relationship of phage t4 and ddvi was demonstrated. inactivation of phage fi1 in these serological reactions showed anomalous nature and did not submit to the rules of the first step reaction. according to investigations of the protein component of virions of these phages by electrophoresis ...	1979	91945
[measurement for serum thyroxine-binding globulin (tbg) and its clinical assessment in diagnosis of thyroid states (author's transl)].	serum levels of thyroxine (t4)-binding globulin (tbg) were determined by a radioimmunoassay using cellulose-linked antibody to tbg. values obtained in healthy young adults averaged 1.62 +/- 0.25 (sd) mg/100 ml, and no significant difference wwas detected between males and females. the tbg levels remained within the normal limit in hyperthyroidism while they were significantly increased in hypothyroidism. interestingly enough, tbg levels were significantly elevated in chronic thyroidities with no ...	1979	92043
comparisons between serum concentrations of thyroxine and thyroxine-binding proteins in samples simultaneously obtained from capillary, peripheral vein, central vein and aorta in newborn infants.	a total number of 40 newborn infants with various maturity were studied: 13 babies without perinatal events, 19 infants recovered from transient diseases, 6 infants with idiopathic respiratory distress syndrome and 2 infants with asphyxia indicating artificial ventilation. comparisons were performed between serum concentrations of thyroxine (t4), thyroxine-binding globulin (tbg), prealbumin (tbpa) and albumin (alb) in capillary versus peripheral vein, aorta versus central vein and, finally, in p ...	1979	103362
characterization of plasmid transformation in bacillus subtilis: kinetic properties and the effect of dna conformation.	transformation of competent cells of bacillus subtilis with antibiotic resistance plasmid dna has shown that (a) competence for plasmid and chromosomal dna develops with similar kinetics; (b) dna linearized with a variety of restriction endonucleases does not transform; (c) ccc plasmid dna is inactivated for transformation by a single nick; (d) t4 ligase restores transforming activity to both nicked and linearized dna; (e) ccc relaxed dna is fully active in transformation; (f) the dna concentrat ...	1979	105246
effect of tri-iodothyronine replacement on the metabolic and pituitary responses to starvation.	to determine the implication of decreased t3 production during fasting, seven normal men were fasted for 80 hours on two occasions; they received 5 microgram of t3 every three hours durnig the second fast. the mean serum t3 concentration declined during the control fast from 120 to 73 ng per deciliter (p less than 0.01), but remained slightly above base-line values during the t3 fast. mean serum t4 concentrations did not change, and mean serum rt3 concentrations increased, during both fasts. the ...	1979	105290
serum concentrations of thyrotropin, thyroid hormones and thyroid hormone-binding proteins during acute and recovery stages of idiopathic respiratory distress syndrome.	a total number of 27 premature infants with idiopathic respiratory distress syndrome (irds) and 52 healthy controls with comparable gestational age and body weights were studied during the first month of life. in infants with irds a reduced thyrotropin (tsh) response to birth was suggested, as serum tsh was lower in irds patients than in controls during the first two days of life. low serum concentrations of thyroid hormones were found in the acute stage of irds reaching minimal values by day 3- ...	1979	105563
thyroid hormone-aldosterone interaction on na+ transport in toad bladder.	repeated administration of thyroxine (t4) in vivo (2 microgram/100 g body wt for 6 days) lowered by 2.3 times (p less than 0.025, df = 18) the basal rate of na+ transport measured by the short-circuit current (scc) in vitro in the urinary bladder of the toad (bufo marinus). this difference was not accounted for by a change in the plasma aldosterone concentration. moreover the response of the scc to aldosterone in vitro was markedly inhibited in bladders from t4-treated animals (p less than 0.001 ...	1979	106733
thyroid function studies in the nephrotic syndrome.	total serum and urinary thyroxine (t4), triiodothyronine (t3), and thyroxine-binding globulin (tbg) as well as serum free t4, thyroid-stimulating hormone (tsh), and t3 resin uptake (t3ru) were measured in seven patients with the nephrotic syndrome. the nephrotic syndrome was defined by proteinuria exceeding 3 g/24 h. all patients were clinically euthyroid. most values for total serum t4, free t4, t3, t3ru, tbg, and tsh were within normal limits. however, the mean serum t3 and tbg values were sig ...	1979	106751
phenolic and nonphenolic ring deiodinations of iodothyronines in cultured hepatocarcinoma cell homogenate from monkey.	iodothyronine monodeiodinase activities in homogenates of cultured monkey hepatocarcinoma cells were measured by the deiodination of [3.5-(125)i]-diiodo-l-thyronine or 3-[3',5'-(125)i]triiodo-l-thyronine (phenolic ring-labeled 'reverse' triiodothyronine). the assay system utilized a small ion-exchange column (ag50w-x4, o.9 x approximately 1 cm) to measure 125i-. both deiodinases were destroyed by boiling for 1 min. maximal nonphenolic ring deiodination was observed at ph 7.9 whereas maximal phen ...	1979	106899
relationship of iodide-induced increase in tsh response to trh to changes in serum thyroid hormones.	large doses of iodide (500 mg three times a day) administered to normal men for 10--12 days caused a rise in basal serum tsh and a concomitant rise in the peak tsh response to trh. the basal and peak levels of tsh were highly correlated (p less than 0.001). however, the iodide-induced rise in the peak tsh after trh was poorly correlated with concomitant changes in serum thyroid hormones. serum t3 wa not lower after iodide and, while serum t4 was somewhat lower, the fall in serum t4 was unexpecte ...	1979	107106
detection of a thyroxine-binding protein physicochemically similar to serum thyroxine-binding globulin in normal human urine.	urine samples from 10 normal adult males were analyzed for t4-binding globulin (tbg) employing a sensitive and specific ria for serum tbg. urine tbg was detected at a concentration of 1.74 +/- 0.87 microgram/100 ml (mean +/- sd). the excretion rate was 13.2 +/- 6.5 microgram/g creatinine. there was no correlation between the daily excretion rate of tbg and the total urinary protein (r = 0.52). analyses of this t4-binding protein by gel filtration and on both reverse flow paper and gel electropho ...	1979	107183
hyperthyroidism in the elderly.	in 65 elderly hyperthyroid patients (age range 50-78 years), sex differences, signs and symptoms and thyroid function were studied and the data were compared with those on 48 young hyperthyroid patients (age range 20-29 years). the incidence of hyperthyroidism was 3.5 times higher in females than in males among the young patients, whereas it was approximately equal in males and females among the elderly patients. signs and symptoms conformed with the textbook description in the young subjects bu ...	1979	107212
tables to estimate total binding capacity of thyroxine-binding globulin from the in vitro thyroid function tests.	equations for an estimate of the total binding capacity of serum thyroxine-binding globulin (tbg-tc) were developed relating this parameter to serum thyroxine concentration (t4) and in vitro uptake (t3u). this extimate demonstrated a highly significant, positive correlation with tbg-tc as measured by electrophoresis in ten normal subjectdividuals with altered tbg-tc but without thyroid dysfunction (ten normal pregnant women, ten healthy women receiving anovulatories, ten nephrotics, and ten pati ...	1979	107292
thyroid function in preterm infants with respiratory distress syndrome.	thyroid function was evaluated in premature infants 30 to 35 weeks ega with severe rds and was compared to that of healthy control subjects of similar ega. the infants with rds had significantly lower serum levels of t3, t4, and ft4i during the first 60, 90, and 30 days, respectively, and had elevated t3ur during the first 10 days. the mean (+/- sd) postdelivery tsh peak was lower in the rds group (32.8 +/- 9.6 muu/ml) than in the control group (60.9 +/- 21.8 muu/ml; p less than 0.005). after tr ...	1979	107304
[validity of scintigraphic and endocrinological methods in classifying autonomous adenomas of the thyroid (author's transl)].	the validity of various scintigraphic and endocrinological methods was assessed in order to classify confirmed autonomous adenomas (aa) and to differentiate aa from euthyroid and hyperthyroid goitres. methods used included: measurement of 131j-uptake 6, 24 and 48 hours after 131j-application, before and after suppression by t3, thyroid scanning, count-rate measurement in the aa and the paranodular tissue, and determination of t4. all patients received 131j-therapy (40,000 rads). in 8 out of 30 s ...	1979	107394
pituitary-thyroid function in spironolactone treated hypertensive women.	four weeks high dose spironolactone treatment (aldactone searle, 100 mg q. i. d.) significantly enhanced the tsh (delta max. 8.5 +/- 4.1 vs. 4.6 +/- 3.1 microunits/ml, p less than 0.05) and t3 (delta max. 32 +/- 27 vs. 11 +/- 16 ng/100 ml, p less than 0.05) responses to an intravenous trh/lh-rh bolus injection in 6 eumenorrhoeic euthyroid hypertensive women, without affecting basal serum tsh, t3 or t4 levels or the basal and stimulated lh, fsh and prolactin values (p greater than 0.10). the mean ...	1979	107696
hypothalamus-pituitary-thyroid axis interactions with pineal gland in the rat.	we examined in the rat several possible relationships between the pineal gland and the hypothalamus-pituitary-thyroid axis. the pineal gland, the retina, and the hypothalamus exhibited a diurnal rhythm in thyrotropin-releasing hormone (trh) content with peak values occurring around 1200 h. this rhythm in the hypothalamus was abolished by constant light but was not affected by pinealectomy. nor did pinealectomy affect hypothalamic trh content, pituitary content of thyroid-stimulating hormone (tsh ...	1979	107814
stability and viability of neisseria gonorrhoeae in various solutions and buffers.	the stability and viability of neisseria gonorrhoeae wp (t4) was tested in a variety of buffers and solutions, many of which are commonly used in gonococcal research. each solution was tested at room temperature for its ability to maintain stability and viability of gonococci in concentrated suspensions and to maintain viability of gonococci in dilute suspensions. the 14 buffers and solutions tested could be divided into four groups based upon these criteria. only a few solutions satisfied all t ...	1979	107855
seasonal variation and the influence of body temperature on plasma concentrations and binding of thyroxine and triiodothyronine in the woodchuck.	woodchuck plasma was collected during four seasons of the year and assayed for total and dialyzable (free) t4 and t3 and for rt3. plasma concentrations of total and free t4 and t3 were higher in the spring (t4, 5.4 +/- 0.6 microgram/dl; free t4, 3.0 +/- 0.4 ng/dl; t3, 202 +/- 22 ng/dl; free t3, 0.51 +/- 0.04 ng/dl) and lower in the prehibernatory fattening period in summer (t4, 2.3 +/- 1.0 microgram/dl; free t4, 1.2 +/- 0.5 ng/dl; t3, 45 +/- 27 ng/dl; free t3, 0.16 +/- 0.10 ng/dl) and fall (t4, ...	1979	108089
transport of thyroxine in the serum of vitamin a-deficient rats.	thyroxine (t4) transport in the serum of rats deficient in vitamin a was studied by electrophoresis after incubation of serum samples with radioactive t4. in serum from vitamin a-deficient rats, the amount of radioactivity bound to the prealbumin zone of the electrophoretograms decreased, whereas there was an increase in the amount of radioactivity bound to the albumin zone. the serum from vitamin a-deficient rats subsequently fed a normal diet (repletion experiment) had an electrophoretic patte ...	1979	108351
interrelation of the pituitary-thyroid system at birth in man.	samples of cord blood derived from 105 normal babies after uncomplicated deliveries were assayed for thyroxine (t4), tri-iodothyronine (t3), reverse tri-iodothyronine (rt3), thyroxine-binding globulin (tbg) and thyrotrophin (tsh). the values for t3, rt3 and tsh were log-normally distributed (geometric means 0.62 nmol/l, 3.28 nmol/l and 10.9 mu./l respectively) and those for t4 and tbg were normally distributed (means 126 nmol/l and 13.7 mg/l), the data were systematically analysed and no evidenc ...	1979	108352
neonatal hypothyroidism detected by the northwest regional screening program.	the northwest regional screening program to detect congenital hypothyroidism in infants born in oregon, montana, alaska, and idaho (combined birthrate of 69,000/ yr) was added to our ongoing screening program in 1975. the program utilizes dried blood filter paper specimens collected routinely in the first few days of life in all four states and again at about 6 weeks of age in oregon only. the screening test consist of an initial thyroxine (t4) measurement; a thyroid-stimulating hormore (tsh) de ...	1979	108659
the effect of (-) trans-delta9-tetrahydrocannabinol, alone and in combination with ethanol, on human performance.	twenty five volunteers received (-) trans-delta9-tetrahydrocannabinol (thc) (320 microgram/kg) or placebo (both orally, t0), and, 60 min later, they consumed an ethanolic beverage (0.54 g/kg) or placebo. the effects of this medication were measured at t1 (100 min after thc ingestion), t2 (160 min), t3 (220 min) and t4 (280 min) using a battery of cognitive, perceptual and motor function tests. factorial analysis indicated that the test procedures could be adequately expressed by four rotated fac ...	1979	108748
changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins during early infancy. studies in healthy fullterm, small-for-gestational age and preterm infants aged 7 to 240 days.	serum concentrations of thyrotropin (tsh), thyroxine (t4), triiodothyronine (t3), thyroxine-binding globulin (tbg), prealbumin (tbpa) and albumin (alb) were determined in 492 blood samples from 127 fullterm (ft), 91 small-for-gestational age (sga) and 88 preterm (pt) healthy infants aged 7 to 240 days. serum t4 decreased about 20% during the first month of life. in infants aged 7--49 days, serum t4 concentrations were significantly lower in sga than in ft infants, and even lower values were foun ...	1979	108916
corticosteroids and thyroid function. different effects on plasma volume, thyroid hormones and thyroid hormone-binding proteins after oral and intravenous administration.	the influence of glucocorticosteroids on plasma volume, thyroid hormones and thyroid hormone-binding proteins was studied in 17 patients. plasma volume was not affected either by i.v. beta-methasone (6 mg daily) or by oral prednisolone (45--180 mg daily) given for 5 days. the serum t3 concentration decreased while rt3 increased independently of the route of administration of corticosteroids. serum t4 concentration decreased after i.v. but not after oral administration of corticosteroids. oral st ...	1979	108922
lobulo-alveolar development of mouse mammary glands is regulated by thyroid hormones.	the mammary glands of euthyroid female c3h/hen mice undergo a series of morphological changes during development. in glands from immature animals, the epithelial component consists of a sparse ductal system with few branches which fills about one fourth of the fat pad. in the adult virgin gland, the epithelial component fills the fat pad with a highly branched ductal system and a few alveoli. in contrast, glands from adult animals maintained in a hypothyroid state by ingestion of thiouracil sinc ...	1979	109279
effects of obesity, total fasting and re-alimentation on l-thyroxine (t4), 3,5,3'-l-triiodothyronine (t3), 3,3',5'-l-triiodothyronine (rt3), thyroxine binding globulin (tbg), cortisol, thyrotrophin, cortisol binding globulin (cbg), transferrin, alpha 2-haptoglobin and complement c'3 in serum.	the effects of total fasting for 31 +/- 10 days followed by re-alimentation with an 800 calorie diet on thyroid function, i.e. t4,t3,rt3,rt3u (resin t3 uptake), and tsh, and on tbg levels in serum were studied sequentially in obese hospitalized patients (n=18). additionally, cortisol, growth hormone, prolactin, parathyrin and free fatty acids were followed as hormonal and metabolic parameters, respectively. further, cbg, transferrin, alpha 2-haptoglobin and complement c'3 were measured as repres ...	1979	115194
inhibitory effect of certain drugs on thyroid hormone binding by human liver cytosol.	effects of dinitrophenol (dnp), salicylate, diphenylhydantoin (dph) and heparin on thyroid-hormone binding by human liver cytosol were studied using pevikon thin-layer electrophoresis. thyroxine (t4) binding by the major cytosol t4-binding protein, ht4-2, was significantly depressed with these drugs, and the displaced t4 was bound by another cytosol binding protein, ht4-1. triiodothyronine (t3) binding by the major cytosol t3-binding protein, ht3-2, was significantly decreased with dph and hepar ...	1979	115198
plasma thyrotropin-releasing hormone, prolactin, thyrotropin, and thyroxine concentrations following the intravenous or oral administration of thyrotropin-releasing hormone.	in a further evaluation of the use of oral thyrotropin-releasing hormone (trh) in puerperally lactating women, a radioimmunoassay for its measurement has been developed. its concentration in plasma as well as that of prolactin (prl), thyrotropin (tsh) and thyroxine (t4) were measured following either intravenous or oral administration of trh. basal concentrations of trh in 14 normally cycling women ranged from less than 5 to 17 pg/ml. two luteal phase studies produced peaks in plasma trh 5 to 10 ...	1979	115316
a numerical comparison of the use of t3-uptake values and of tbg levels for the estimation of free thyroxine in serum.	the correlation of the diagnostic indices fti and t4/tbg with actual free t4 levels (ft4) was investigated by numerical analysis. it was shown that, ft4 being kept constant, both indices vary with altered tbg concentrations. thus neither index is truly proportional to ft4. in this respect both indices appear doubtful tools for diagnosing patients with abnormal tbg levels. a "map" constructed by plotting t4 versus t3u appeared to offer a higher discriminatory potential with respect to pathologic ...	1979	115623
potentiation by indomethacin of trh-induced tsh secretion in the rat.	we have studied the effect of two inhibitors of prostaglandin synthesis on the basal and trh-stimulated plasma tsh levels in the rat. animals were injected sc daily with indomethacin 3 mg/0.5 ml) or aspirin (16--30 mg/0.5 ml) for 3 days. the plasma t4 and t3 were consistently lower in the indomethacin or aspirin groups than in the controls, while the basal tsh levels did not change. indomethacin treatment significantly potentiated the tsh response to synthetic trh (20 ng. iv) in intact and thyro ...	1979	115671
[changes of plasma levels of trh and its target hormones by two hour constant intravenous infusion of trh tartrate in man (author's transl)].	constant iv infusion of trh tartrate for 2 hours was administered to normal men in a dosage of 0.5 (n=4), 1.0 (n=2) and 2 (n=4) mg/120 minutes. measurements at every 15 minutes were performed for plasma levels of trh, tsh, thyroxine (t4) and triiodothyronine (t3) by radioimmunoassay. plasma levels of trh increased promptly and stayed at the same levels until the end of the infusion. the mean clearance rate (mrc), half-life and volume of distribution of trh were respectively, 4.62 +/- 0.53 l/min. ...	1979	115728
the distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey.	immunohistochemical methods have been used to describe the distribution of neurophysin i- and oxytocin-stained fibers in the spinal cord. in albino rats of either sex, such fibers descend through the dorsal part of the lateral funiculus to the caudal end of the cord. fibers leave the lateral funiculus to innervate the marginal zone of the dorsal horn at all levels, and the intermediolateral column at thoracic, lumbar and sacral levels. some fibers course medially through the intermediate gray to ...	1979	115910
production and metabolism of thyroid hormones in protein-deficient and food-restricted pregnant rats.	thyroxine (t4) and triiodothyronine (t3) concentrations in the plasma and their metabolic clearance and production rates were studied in pregnant protein-deficient and food-restricted rats on the 20th day of gestation. total t3 levels in the plasma were significantly reduced in malnourished dams, with those of food-restricted dams being consistently lower than those of protein-deficient dams. there were no changes in plasma total t4 concentrations as a result of dietary treatment. unbound t4 and ...	1979	115976
bacteriophage t4-coded dihydrofolate reductase: synthesis, turnover, and location of the virion protein.	dihydrofolate reductase plays a dual role in bacteriophage t4, first, as an enzyme of thymidylate metabolism, and second, as a protein component of the tail baseplate. antibody to the purified enzyme has been used to study its synthesis and intracellular turnover. the antibody specifically precipitates one protein from t4d-infected cell extracts. this has been identified as dihydrofolate reductase, although the polypeptide molecular weight (22,000) is lower than that earlier determined for this ...	1979	116011
[thyroxine-binding globulin (tbg). clinical studies on the regulation of tbg concentration in serum and the value of tbg for the evaluation of thyroid function].	1. the radioimmunoassay (ria) and the competitive ligand binding assay (clba) are convenient routine methods for the precise and reproducible measurement of tbg in large numbers of serum samples. 2. there is an age dependent variation of the tbg-concentration in serum. there is a steady decrease of tbg with increasing age with a minimum between the 20th and 50th year. in higher age tbg increases again significantly. 3. there are significantly negative correlation between tbg-serum levels on the ...	1979	116950
further characterization of a cell-free system for measuring replicative and repair dna synthesis with cultured human fibroblasts and evidence for the involvement of dna polymerase alpha in dna repair.	dna repair synthesis can be specifically measured in osmotically opened, confluent cultured human fibroblasts after exposure to dna damaging agents such that both induction and mediation of dna repair synthesis can take place in this cell-free system. alternatively, by utilizing osmotically shocked, log phase cells and altering the dna precursors, ph and ionic strength, replicative dna synthesis can be specifically monitored. autoradiographic studies show that virtually all of the nuclei from th ...	1979	117431
[clinical use of the assay of the thyroxin-binding-globulin (tbg) and of the calculated index: t4/tbg (author's transl)].	the level of tbg in normal adults is 2.21 +/- 0.4 mg/100 ml, without any sex difference. tbg levels are high in the neonatal period (3.26 +/- 0.49 mg/100 ml) and in children under the age of 1 year (2.61 +/- 0.66 mg). estrogens induce a significant increase (3.96 +/- 1.0 mg) and corticoids a significant decrease of tbg (1.44 +/- 0.32 mg). tbg is also decreased in thyrotoxicosis (1.88 +/- 0.34 mg) but normal in hypothyroidism. there is a strong correlation between t4 and tbg levels, and the t4/tb ...	1979	117738
[serum thyroid hormones and tsh response to trh during treatment of graves' disease by carbimazole (author's transl)].	serum concentrations of thyroxine (t4), triiodothyronine (t3) free thyroxine index (f.t.i.) and tsh response to trh were evaluated in 55 graves' diseases treated by carbimazole. there is a good correlation between serum thyroid hormones and clinical state: 83,7% for t4; 79,5% for t3; on the other hand there is a discrepancy between t3 and t4 in many cases and between delta tsh and t4 (47%) or t3 (46%). the decrease of t4 occurs before that of t3: 46,6% normal at the 4th month and 72,5% at the 9t ...	1979	117739
[neonatal screening for hypothyroidism. nord-picardie regional experience (author's transl)].	the routine t4 determination from filter paper blood spots, with supplementary t.s.h. and t.b.g. determinations on subnormal t4 values, is a reliable method for neonatal hypothyroidism screening. preliminary results, presently reported, agree with previous studies. however a larger experience is still necessary to decide the best way for mass-screening of congenital hypothyroidism.	1979	117740
competitive ligand - binding assay for thyroxine binding globulin. comparison with tbg radioimmunoassay and t3 uptake test.	a simple and reproducible competitive ligand binding assay has been utilized to measure serum tbg concentration. in euthyroid subjects tbg concentration (mean +/- sd, mg/l) was 33.7 +/- 4; hyperthyroid 24 -/+ 6; t3-thyrotoxicosis 20 +/- 7; hypothyroid 37 -/+ 7; pregnant 67 -/+ 18; post-partum period 59.8 -/+ 17; oral contraceptives 45 -/+ 7. the correlation of clba with ria measurement of tbg was significant (p less than 0.001). the estimations of serum tbg by clba correlated significantly with ...	1979	117741
chronic dopamine receptor stimulation using bromocriptine: failure to modify thyroid function.	administration of 2.5 mg bromocriptine (parlodel), a dopamine agonist, on two occasions to six normal volunteers did not alter the plasma tsh response to an i.v. injection of 100 micrograms trh, but significantly (p less than 0.01) blunted it after 200 micrograms. chronic bromocriptine treatment (7.5--50 mg/day) of fifteen acromegalic subjects failed to influence basal plasma tsh or the response pattern to 200 micrograms trh. the thyroxine binding index (tbi) and the levels of t3 and t4 were not ...	1979	117954
free thyroxine (ft4) and free triiodothyronine (ft3) in autonomous thyroid nodules.	total and free thyroid hormones (t3, t4, ft3 and ft4), tsh and its response to trh were determined in sixty-three patients affected by autonomous thyroid nodules: mean concentrations of free t3 (ft3) were significantly higher in hot nodules (suppressing extranodular tissue on the scan) as compared to warm ones, even in those cases where total t3 and t4 were within normal ranges (hot nodules, group as a whole: 8.8 +/- 3.5 pg/ml; warm nodules: 5.3 +/- 1.2; hot nodules with normal total t3 and t4 c ...	1979	117956
function of the hypothalamo-hypophysial-thyroid axis in chronic renal failure.	hypothalamo-hypophysial-thyroid function has been studied in twenty-five patients with chronic renal failure. eight were receiving conservative treatment, nine peritoneal dialysis and eight haemodialysis. all were clinically euthyroid. total thyroxine (t4) and triiodothyronine (t3) levels were reduced but free t4 levels were normal, while free t3 was reduced in patients with the most severe renal failure. it is suggested that the binding of thyroid hormones by the transport proteins is reduced a ...	1979	117957
[the psychotropic action of trh].	during a double-blind trial about using trh perfusions, the authors didn't established any antidepressive effect. on the other hand they observed an anxiety reaction under a 1,200 microgram in perfusion. the study of the basic level of t3, t4, t.s.h. and prolactin corroborated the normality of the biological evaluation among the depressed. no difference of the hormonal response under t.r.h. was established depending on different types of depression. the authors reported that the prolactin respon ...	1979	117999
unconjugated thyroxine and triiodothyronine in urine: influence of age, sex, drugs and thyroid function.	the 24 h urinary excretion (du) of t4 and t3, determined by radioimmunoassays using extraction and separation on sephadex columns, is higher in men than in women (mean du-t4 and du-t3 +/- 2 sd: 2.6 +/- 0.9 vs. 2.2 +/- 1.0 and 2.5 +/- 1.0 vs. 2.0 +/- 0.8 nmol, respectively). the excretion of t3 decreases with age, but expressed relatively to du-creatinine there is no effect of age and sex. children have increased t4 and t3 to creatinine excretion ratios and neonates excrete predominantly t4. oest ...	1979	118510
determination of free thyroid hormone fractions using a simple t3-uptake test.	results from a simple, fast and inexpensive sephadex t3-uptake test (t3u) have been compared to free fractions of serum thyroxine (t4) and triiodothyronine (t3) determined by a dialysis procedure in forty-six sera from hypothyroids, 154 sera from euthyroids and ninety-one sera from hyperthyroids. sera with high tbg levels were included in these groups. a second order correlation (r = 0.90) was found between t3u and free t4 and t3 fractions. the t3u had a low diagnostic value for all three groups ...	1979	118511
abnormal thyroid function tests in devere non-thyroidal illness: diagnostic and pathophysiologic aspects.	in vitro thyroid function tests were studied in twenty-three patients with serious non-thyroidal illness. all had reduced protein binding of serum thyroxine (t4) and serum triiodothyronine (t3) as reflected in increased t4 and t3 uptake tests. the mean t4-binding prealbumin (tbpa) capacity and concentration were about one third the normal levels, whereas the decrease in r4-binding globulin (tbg) was much smaller. increased serum free fatty acids and reverse t3 were frequently observed, but in vi ...	1979	118513
serum t3 and t4 determinations during the trh test as a complement to improved discriminatory power in suspect hyperthyroidism.	the aim of the study was to determine whether the addition of t3 and t4 determination in connection with a routine trh-test could increase the discriminatory power of the test. thus, forty-one patients with suspect hyperthyroidism were examined and samples for t3 and t4 and tsh determinations were drawn prior to the administration of trh and at 20 and 60 min thereafter. the results showed that the addition of these thyroid hormone estimations did not increase the clinical value of the trh-test.	1979	119304
tsh and prl response to thyrotrophin-releasing hormone in children with chronic renal failure undergoing haemodialysis.	eight children (aged between 8 1/2 and 15 1/2 years) with chronic renal failure receiving intermittent haemodialysis, and 2 children with renal transplants were studied. the response of tsh and prolactin (prl), and basal t4 and t3 values was measured. basal tsh was normal, and rose only slightly after trh stimulation. plasma t4 and t3 were below normal levels in 6 children. mean basal prl was raised and could not be stimulated by trh. this study demonstrates the involvement of the hypothalamus a ...	1979	119489
effect of danazol on thyroid function in women.	a longitudinal study of thyroid function during danazol treatment was performed in 18 women. serum concentrations of thyroid stimulating hormone (tsh), thyroxine (t4), tri-iodothyronine (t3), free t4-and free t3 index as well as thyroid hormone binding globulin (tbg) were measured before and during 6 months therapy. thyroxine binding globulin showed a marked decrease to one third of the pretreatment level. all the hormones showed significant alterations within the normal ranges for this group. ...	1979	119954
serum thyroxine, serum % -- t3 -- binding, and serum t3 in zambians.	serum total thyroxine (t4) was measured in clinically euthyroid and clinically hyperthyroid subjects, using the method of competitive protein binding. in 26 euthyroid subjects the mean +/- 1sd was 7.7 +/- 1.8 micrograms/dl and in 17 clinically hyperthyroid subjects, the mean +/- 1sd was 18.1 +/- 3.1 micrograms/dl. this difference is statistically significant. serum % 125(1) -- t3 binding was measured using the principle of competition for 125(1) -- t3 between the unknown serum and the resin in t ...	1979	120088
combined effect of ethanol, and thyroid releasing hormone (trh) or org 2766, on serum prolactin, thyroid stimulating hormone (tsh) and thyroid hormones (t3, t4 and rt3).		1979	120107
effect of cyproterone acetate (ca) on growth and endocrine function in precocious puberty.	16 girls with precocious puberty have been studied. following low dosage cyproterone acetate (ca) therapy (mean daily dosage 65 mg/m2bsa) a beneficial effect on growth and skeletal maturation was observed. during high dosage therapy (150 mg/m2 per day) endocrinological studies were performed in 10 of these patients. there was no significant difference in hgh levels (insulin- and arginine-test), t3 and tsh values (trh-test) between patients and controls, t4 concentration was significantly increas ...	1979	120672
prolactin secretion and nodular goiter. (hypothetical correlations).	in a group of 129 female patients with nodular goiter, graves' disease and primary hypothyroidism, the prl and tsh secretions were studied in parallel. concurrent changes in the two hormones were evident only in conditions of marked hyper- or hypothyroidism. in the patients with non-toxic nodular (single or multiple) goiter the tsh showed low or normal values, while the prl appeared normal or elevated. from these results two important conclusions can be drawn: 1. the t3 and t4 levels interact wi ...	1979	120979