Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| herpes virus type 2 infection and genital symptoms in primary care patients. | we aimed to identify whether genital symptoms were associated with unrecognized herpes simplex virus type 2 (hsv-2) infection in a primary care population. | 2006 | 16601657 |
| herpes simplex virus infection in women in the wihs: epidemiology and effect of antiretroviral therapy on clinical manifestations. | to determine the prevalence of infection with herpes simplex virus types 1 (hsv-1) and 2 (hsv-2) among women with and at high risk for hiv infection, and to evaluate the effect of haart on the recurrence of genital lesions. | 2006 | 16603858 |
| mesenchymal stem cells are susceptible to human herpesviruses, but viral dna cannot be detected in the healthy seropositive individual. | allogeneic stem cell transplantation is often complicated by reactivation of herpesviruses. mesenchymal stem cells (msc) are immunomodulatory and may be used to treat graft-versus-host disease. we investigated if herpesviruses infect and can be transmitted by msc, and if msc suppress immune responses to various infectious agents. mesenchymal stem cells from healthy seropositive donors were evaluated with polymerase chain reaction for the most common herpesviruses: cytomegalovirus (cmv), herpes s ... | 2006 | 16604097 |
| association of two membrane proteins encoded by herpes simplex virus type 2, ul11 and ul56. | herpes simplex virus (hsv) acquires envelope by budding into trans-golgi network (tgn)-derived vesicles. previous studies showed that the ul11 gene product enables efficient virion envelopment and export from infected cells and is incorporated into virions as tegument protein. at its n-terminus, ul11 is dually acylated by myristoic and palmitoic acids. fatty acylation of ul11 provides both membrane binding strength and golgi-targeting specificity. we show here that ul11 interacts with ul56 prote ... | 2006 | 16604447 |
| genital herpes vaccines--cause for cautious optimism. | the high prevalence of herpes simplex virus infections in many communities, its numerous serious physical and psychological complications and its importance in enhancing the transmission of hiv make this virus an obvious target for prevention by vaccination. randomised clinical trials of only one genital herpes vaccine has shown efficacy so far. analysis of clinical results is complicated by the difference between disease and infection, different results for males and females and the interaction ... | 2006 | 16607967 |
| recombinant vesicular stomatitis virus vectors expressing herpes simplex virus type 2 gd elicit robust cd4+ th1 immune responses and are protective in mouse and guinea pig models of vaginal challenge. | recombinant vesicular stomatitis virus (rvsv) vectors offer an attractive approach for the induction of robust cellular and humoral immune responses directed against human pathogen target antigens. we evaluated rvsv vectors expressing full-length glycoprotein d (gd) from herpes simplex virus type 2 (hsv-2) in mice and guinea pigs for immunogenicity and protective efficacy against genital challenge with wild-type hsv-2. robust th1-polarized anti-gd immune responses were demonstrated in the murine ... | 2006 | 16611905 |
| lambda interferon (ifn-lambda), a type iii ifn, is induced by viruses and ifns and displays potent antiviral activity against select virus infections in vivo. | type iii interferons (ifns) (interleukin-28/29 or lambda interferon [ifn-lambda]) are cytokines with ifn-like activities. here we show that several classes of viruses induce expression of ifn-lambda1 and -lambda2/3 in similar patterns. the ifn-lambdas were-unlike alpha/beta interferon (ifn-alpha/beta)-induced directly by stimulation with ifn-alpha or -lambda, thus identifying type iii ifns as ifn-stimulated genes. in vitro assays revealed that ifn-lambdas have appreciable antiviral activity agai ... | 2006 | 16611910 |
| decline in the prevalence of antibodies to herpes simplex virus types 1 and 2 among israeli young adults between 1984 and 2002. | the objective of this study was to estimate the seroprevalence of herpes simplex virus (hsv) types 1 and 2 in male and female soldiers discharged from the israel defense force (idf) over a period of 18 years. | 2006 | 16614586 |
| [trends in antibody prevalence of herpes simplex virus types 1 and 2]. | 2006 | 16615468 | |
| [epidemiology of genital herpes]. | 2006 | 16615470 | |
| [diagnosis of hsv-1, hsv-2 infection]. | 2006 | 16615472 | |
| [serodiagnosis for alphaherpesvirinae infections]. | 2006 | 16615474 | |
| [acute retinal necrosis due to herpesviridae infections]. | 2006 | 16615476 | |
| [herpes encephalitis]. | 2006 | 16615480 | |
| [neonatal herpes]. | 2006 | 16615481 | |
| [meningitis]. | 2006 | 16615482 | |
| [treatment of neonatal herpes]. | 2006 | 16615488 | |
| ribonucleotide reductase inhibitors as anti-herpes agents. | ribonucleotide reductases (rnrs) supply the 2'-deoxyribonucleotide building blocks for dna synthesis in mammalian cells and for herpes viruses. the viral-encoded rnrs have unique protein sequences that differ from mammalian enzyme primary structures. selective inhibition of a viral rnr might provide an approach to new anti-herpes agents with minimal effects on the mammalian host rnrs. this review summarizes efforts to develop anti-herpes agents that selectively target viral-encoded rnrs. | 2006 | 16621038 |
| potent protective cellular immune responses generated by a dna vaccine encoding hsv-2 icp27 and the e. coli heat labile enterotoxin. | a mouse model was employed to evaluate protective cellular immune responses induced by an immediate early antigen of hsv-2. particle-mediated dna vaccination of mice with a dna plasmid-encoding icp27 resulted in the induction of icp27-specific ifn-gamma and tnf-alpha production in balb/c mice, but little protection to intranasal challenge with wild type hsv-2. however, when the dna vaccine was supplemented with as little as 50ng of a vector encoding the a and b subunits of the escherichia coli h ... | 2006 | 16621198 |
| antiviral activity of cyclosaligenyl prodrugs of the nucleoside analogue bromovinyldeoxyuridine against herpes viruses. | a series of 42 lipophilic bromovinyldeoxyuridine monophosphates (bvdumps) are presented as potential prodrugs of the antiviral agent (e)-5-(2-bromovinyl)-2'-deoxyuridine (bvdu). the 5'-cyclosal-masking group technique has been applied to this cyclic nucleoside analogue to achieve delivery of the monophosphate of bvdu inside the target cells. the new substances have been tested for their antiviral activity against herpes simplex virus types 1 and 2 (hsv-1 and -2), thymidine kinase-deficient (tk(- ... | 2006 | 16621459 |
| no evidence of relation between maternal exposure to herpes simplex virus type 2 and risk of schizophrenia? | the authors examined whether maternal exposure to herpes virus type 2 is associated with risk for adult schizophrenia. | 2006 | 17151171 |
| [reversible posterior leukoencephalopathy syndrome in hashimoto's encephalopathy: a case report]. | a 45-year-old woman with breast cancer was admitted to our hospital because of several episodes of disturbed consciousness and generalized convulsions. while these symptoms resolved quickly, dysphagia and bilateral blepharoptosis persisted. neurological findings were improved by steroid therapy. mri on the first hospital day showed t2/flair high intensity lesions in both occipital lobes, but these lesions diminished on the 8th day, indicating reversible posterior leukoencephalopathy syndrome. a ... | 2006 | 17154034 |
| herpes simplex virus infections in preterm infants. | neonatal herpes simplex virus infections cause significant neonatal mortality and morbidity, but the course and prognosis in preterm infants is not well documented. we performed a retrospective review of herpes simplex virus infections at out institution within the first 30 days after birth in infants who were born at <37 weeks to help better define the symptoms and signs of herpes simplex virus infections in preterm infants and to assist in prognosis. | 2006 | 17142491 |
| antibodies against six human herpesviruses in relation to seven cancers in black south africans: a case control study. | infections with certain human herpesviruses have been established as risk factors for some cancer types. for example, epstein-barr virus is considered a cause of burkitt's lymphoma and other immunosuppression related lymphomas, hodgkin lymphoma, and nasopharyngeal cancer. several other human herpesviruses have been linked to cancers but the totality of evidence is inconclusive. | 2006 | 17150131 |
| genital herpes. | 2006 | 17151051 | |
| cutting edge: plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ. | dendritic cells (dcs) are powerful apcs capable of activating naive lymphocytes. of the dc subfamilies, plasmacytoid dcs (pdcs) are unique in that they secrete high levels of type i ifns in response to viruses but their role in inducing adaptive immunity remains divisive. in this study, we examined the importance of pdcs and their ability to recognize a virus through tlr9 in immunity against genital hsv-2 infection. we show that a low number of pdcs survey the vaginal mucosa at steady state. upo ... | 2006 | 17114418 |
| primary herpes simplex virus type-2 infection as a cause of liver failure after liver transplantation. | we report a case of fatal primary herpes simplex virus type-2 (hsv-2) infection following liver transplantation, which manifested with fever and liver failure in the absence of muco-cutaneous disease. the infection was characterized by high levels of hsv dna in blood and the patient's inability to mount hsv-specific t-cell responses while showing preserved t-cell responses against cytomegalovirus. the donor was hsv-1 immunoglobulin g (igg) seronegative and hsv-2 igg seropositive, whereas the rec ... | 2006 | 17116138 |
| impact of suppressive herpes therapy on genital hiv-1 rna among women taking antiretroviral therapy: a randomized controlled trial. | to demonstrate a causal relationship between herpes simplex virus 2 (hsv-2) and increased genital hiv-1-rna shedding in women on haart. | 2006 | 17117016 |
| seroprevalence of herpes simplex virus-1 and -2 in attendees of a sexually transmitted infection clinic in singapore. | we studied the seroprevalance of hsv (herpes simplex virus)-1 and hsv-2 in outpatient attendees of a sexually transmitted infection (sti) clinic in singapore and examined their knowledge and attitudes towards hsv infection. | 2006 | 17112439 |
| bacterial vaginosis in women of low socioeconomic status living in slum areas in chennai, india. | bacterial vaginosis (bv) is a common cause of vaginitis among women of childbearing age. this study was performed to investigate the prevalence of bv and its association with sexually transmitted infections among 487 women of low socioeconomic status. blood, vaginal and endocervical swabs were tested for hiv, herpes simplex virus-2 (hsv-2), treponema pallidum, bv, chlamydia trachomatis, neisseria gonorrhoea and trichomonas vaginalis. of the women screened for bv, 120 (25, 95% ci 20.8-28.4) were ... | 2006 | 17112444 |
| 3'-carbon-substituted pyrimidine nucleosides having a 2',3'-dideoxy and 2',3'-didehydro-2',3'-dideoxy structure: synthesis and antiviral evaluation. | the bis(tributylstannyl) derivative of 2',3'-didehydro-2',3'-dideoxyuridine (d4u) underwent an anionic 5'-o-->3'-c stannyl migration to yield the 3'-tributylstannyl-d4u. this compound, with its vinylstannane structure, allowed ready access to the preparation of 3'-carbon-substituted analogues through the stille reaction. a conventional transformation of the uracil moiety of these d4u analogues led to the corresponding 2',3'-didehydro-2',3'-dideoxycytidine (d4c) counterparts. some 2',3'-dideoxycy ... | 2006 | 17066900 |
| early diffusion-weighted magnetic resonance imaging findings in neonatal herpes encephalitis. | neonatal herpes encephalitis is usually caused by herpes simplex virus type 2 and results in significant morbidity and mortality. imaging diagnosis with ultrasound, computed tomography scan and conventional magnetic resonance imaging may be normal in the early course of the disease. in this case diffusion-weighted magnetic resonance imaging detected the disease process earlier and better than the conventional t2-weighted or fluid-attenuated inversion recovery imaging sequences. the use of diffus ... | 2006 | 17096722 |
| recurrent aseptic meningitis associated with herpes simplex virus type 2. | 2006 | 17098119 | |
| beseiged. | 2006 | 17071158 | |
| seroprevalence of herpes simplex virus type 2 in multiple sclerosis. | it has been proposed that multiple sclerosis (ms) might be a sexually transmitted disorder. there is evidence that seropositivity to herpes simplex virus type 2 (hsv-2) correlates well with the number of sexual partners. accordingly, a raised overall hsv-2 seroprevalence in ms would lend support to this theory. | 2006 | 17083334 |
| [genital herpes]. | genital herpes simplex virus (hsv-1 and hsv-2) infection is an ulcerative, lifelong, recurring sexually transmitted disease of increasing epidemiologic worldwide importance. transmission occurs by close skin contact, usually during asymptomatic virus shedding. the virus persists in the dorsal root ganglion where it is not accessible to the host's immune system. the most important risk factor is a person's number of lifetime sex partners. the more extensive first-episode infection is followed by ... | 2006 | 17089142 |
| immunological profiles of patients with chronic myeloid leukaemia. i. state before the start of treatment. | in view of the increasing interest in the immunotherapy of cml it seems highly desirable to broaden the present knowledge on the immune reactivity of cml patients. a group of 24 patients and 24 healthy controls were studied for the total of 15 immunological parameters, including the prevalence of antibodies against human herpesviruses and papillomaviruses. to clearly discriminate between changes associated with the disease and those induced by the therapy, all patients were enrolled prior to the ... | 2006 | 17089915 |
| antiviral effect of aqueous extracts from species of the lamiaceae family against herpes simplex virus type 1 and type 2 in vitro. | aqueous extracts from species of the lamiaceae family were examined for their antiviral activity against herpes simplex virus (hsv). extracts from lemon balm (melissa officinalis), peppermint (mentha x piperita), prunella (prunella vulgaris), rosemary (rosmarinus officinalis), sage (salvia officinalis) and thyme (thymus vulgaris) were screened. their inhibitory activity against herpes simplex virus type 1 (hsv-1), type 2 (hsv-2) and an acyclovir-resistant strain of hsv-1 (acv (res)) was tested i ... | 2006 | 17091431 |
| longitudinal evaluation of herpes simplex virus dna load during episodes of herpes labialis. | few studies have performed sequential evaluation of the herpes simplex virus (hsv) load using quantitative pcr during episodes of herpes labialis. | 2006 | 17046320 |
| seroprevalence of herpes simplex virus type 1 and type 2 in turkey. | herpes simplex virus (hsv) infections are among the most common infectious diseases in humans. the prevalence of herpes simplex viruses type 1 (hsv-1) and type 2 (hsv-2) varies widely across the world. hsv-2 infection is the primary cause of genital herpes. it is highly prevalent in human populations in many parts of the world, and is the most common cause of genital ulcer disease worldwide. in spite of the large prevalence and growing incidence of herpes simplex infection (hsv-1 and hsv-2), rel ... | 2006 | 17062037 |
| hsv-2 antibodies in female sex workers in vietnam. | little information is available on the prevalence of herpes simplex type-2 (hsv-2) antibodies among groups at potential high risk of hiv in asia. this study was carried out to determine the prevalence of hsv-2 antibodies and correlates of hsv-2 infection in female sex workers (fsws) in border provinces of vietnam. nine hundred and four fsws in five border provinces of vietnam were interviewed about selected sociodemographic and behavioural characteristics, and information about partners by a sta ... | 2006 | 17062180 |
| comparison of different polymerase chain reaction methods for detection of herpes simplex virus types 1 and 2 encephalitis. | 2006 | 17047902 | |
| association of herpes simplex virus type 2 infection and syphilis with human immunodeficiency virus infection among men who have sex with men in peru. | we evaluated associations between human immunodeficiency virus (hiv) infection, herpes simplex virus type 2 (hsv-2) infection, and syphilis among men who have sex with men (msm) in peru. | 2006 | 17054077 |
| famciclovir for the treatment of recurrent genital herpes: a clinical and pharmacological perspective. | herpes simplex virus is one of the most common causes of genital ulcer disease worldwide. herpes simplex virus-2 is the more common cause of genital herpes, a chronic infection that is characterised by periodic reactivation, with the capacity to produce recurrent symptomatic disease in the host (e.g., vesicular eruption), as well as intermittent asymptomatic shedding. relapsing episodes may be physically and psychologically distressing. shedding accounts for the majority of cases of transmission ... | 2006 | 17059383 |
| association between hsv-2 and hiv-1 viral load in semen, cervico-vaginal secretions and genital ulcers of thai men and women. | we studied the association between herpes simplex virus type-2 (hsv-2) and hiv-1 viralload in plasma, semen, cervico-vaginal secretions and genital ulcers. forty-seven (68%) men and 57 (80%) women were hsv-2 antibody positive, of whom 12 (26%, 95% confidence interval [ci] 20, 32) and five (8%, 95% ci 4, 12), respectively, had hsv-2 genital shedding detected by polymerase chain reaction. the mean hiv-1 seminal and cervico-vaginal viral loads did not differ significantly according to the presence ... | 2006 | 17059638 |
| microarray assay for detection and discrimination of orthopoxvirus species. | a microarray method was developed for simultaneous detection and identification of six species of orthopoxvirus (opv) including variola, monkeypox, cowpox, camelpox, vaccinia, and ectromelia viruses. the method allowed us to discriminate opv species from varicella-zoster virus (vzv), herpes simplex 1 virus (hsv-1), and herpes simplex 2 virus (hsv-2) that cause infections with clinical manifestations similar to opv infections. the nucleotide sequences of the c23l/b29r and the b19r genes identifie ... | 2006 | 16927285 |
| effect of valacyclovir on viral shedding in immunocompetent patients with recurrent herpes simplex virus 2 genital herpes: a us-based randomized, double-blind, placebo-controlled clinical trial. | to determine the efficacy of daily suppressive therapy with a 1-g dose of valacyclovir in reducing total (clinical and subclinical) herpes simplex virus 2 (hsv-2) shedding compared with placebo in immunocompetent patients diagnosed as having recurrent hsv-2 genital herpes. | 2006 | 17036557 |
| herpes simplex and epstein-barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with fludarabine. | multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (cll). we describe a patient with a cll who developed an herpes virus lymphadenitis. inmunohistochemical study was positive for hsv-1, hsv-2, and epstein-barr virus (ebv). the coinfection of ebv with a profile of expresion of viral latent genes type iii, is usually seen in inmunodepressed patients. to the best of our knowledge, this is the first reported case of a multiple human herpes vi ... | 2006 | 17044837 |
| hiv among pregnant women in moshi tanzania: the role of sexual behavior, male partner characteristics and sexually transmitted infections. | women continue to be disproportionately affected by hiv in tanzania, and factors contributing to this situation need to be identified. the objective of this study was to determine social, behavioral and biological risk factors of hiv infection among pregnant women in moshi urban, tanzania. in 2002-2004, consenting women (n = 2654), attending primary health clinics for routine antenatal care were interviewed, examined and biological samples collected for diagnosis of hiv and other sexually transm ... | 2006 | 17044932 |
| acidform inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. | the acidic vaginal milieu is presumed to inactivate pathogens but is neutralized by semen. this notion fostered the development of acid-buffering products, such as acidform (developed by program for topical prevention of conception and disease, rush university, and licensed by instead), as microbicides. however, the extent and mechanism of protective activity provided by buffering gels is not known. exposure of herpes simplex virus (hsv) to ph 4.5 or lower irreversibly inactivated hsv and reduce ... | 2006 | 16941346 |
| chapter 1: hpv in the etiology of human cancer. | the causal role of human papillomavirus (hpv) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. most cancers of the vagina and anus are likewise caused by hpv, as are a fraction of cancers of the vulva, penis, and oropharynx. hpv-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus and for about 30-40% of cancers of the vulva, penis, and oropharynx. other cancers causally linked to hpv are non-melanoma skin cancer and canc ... | 2006 | 16949995 |
| role of bcl-2 expression for productive herpes simplex virus 2 replication. | herpes simplex viruses infect a variety of cells in vitro. however, not all infected cells sustain a fully productive replication of these viruses. we have shown that, in u937 monocytoid cells, herpes simplex virus 2 (hsv-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. this effect was associated with a down-regulation of the bcl-2 protein. we therefore asked whether destabilization of bcl-2 expression could act as a limiting fact ... | 2006 | 16950491 |
| invader plus method detects herpes simplex virus in cerebrospinal fluid and simultaneously differentiates types 1 and 2. | we report here on the development and validation of a prototype invader plus method for the qualitative detection of herpes simplex virus types 1 and 2 in cerebrospinal fluid (csf). the method combines pcr and invader techniques in a single, closed-tube, continuous-reaction format that gives an analytical sensitivity of approximately 10 copies per reaction. the clinical sensitivity and specificity were 100.0% and 98.6%, respectively, when the results of the method were validated against the resu ... | 2006 | 16954297 |
| universal prenatal herpes screening is a bad idea in pregnancy. | 2006 | 16962863 | |
| herpes simplex virus in the saliva of peripheral bell's palsy patients. | the first herpes virus to be described was types 1 and 2, whose denomination is herpes simplex 1 and 2 or hsv-1 and hsv-2. these viruses have specific biological characteristics, such as the ability to cause different kinds of diseases, as well as to establish hosts latent or persistent lifetime infections and also of being reactivated, causing lesions that can be located at the same site of the initial primary infection or close to it. it is suggested that this virus reactivation in the genicul ... | 2006 | 16917546 |
| influence of storage temperature on the stability of hiv-1 rna and hsv-2 dna in cervicovaginal secretions collected by vaginal washing. | variability in the handling of samples of genital secretions prior to quantitation of hiv-1 rna and hsv dna may profoundly affect both the detection and quantitation of these nucleic acids. over 144 h, we evaluated, the influence of storage temperature (4 degrees c, 20 degrees c, 30 degrees c) on the quantity of hiv-1 rna and hsv-2 dna in hiv and hsv negative cervicovaginal lavage pools spiked with known amounts of hiv-1 and hsv-2 and in hiv-1 and hsv-2 co-infected cervicovaginal lavage pools. t ... | 2006 | 16919788 |
| trends in herpes simplex virus type 1 and type 2 seroprevalence in the united states. | herpes simplex virus type 1 (hsv-1) and type 2 are common infections worldwide. herpes simplex virus type 2 (hsv-2) is the cause of most genital herpes and is almost always sexually transmitted. in contrast, hsv-1 is usually transmitted during childhood via nonsexual contacts. preexisting hsv-1 antibodies can alleviate clinical manifestations of subsequently acquired hsv-2. furthermore, hsv-1 has become an important cause of genital herpes in some developed countries. | 2006 | 16926356 |
| human cd4+ cd25 high cells suppress proliferative memory lymphocyte responses to herpes simplex virus type 2. | lymphocytes with the regulatory cd4+ cd25+ phenotype frequently suppress memory t-cell responses. murine herpes simplex virus type 1 (hsv-1) models have shown that cd4+ cd25+ cells can limit immunity-mediated corneal damage but slow viral clearance. we investigated the effect of cd4+ cd25+ cells from healthy hsv-2-infected humans on recall proliferative (cd4) responses to hsv-2. depletion and reconstitution experiments were consistent with a suppressive effect of autologous blood-derived cd4+ cd ... | 2006 | 16873284 |
| resveratrol suppresses nuclear factor-kappab in herpes simplex virus infected cells. | resveratrol inhibits herpes simplex virus (hsv) replication by an unknown mechanism. previously it was suggested that this inhibition may be mediated through a cellular factor essential for hsv replication [docherty, j.j., fu, m.m., stiffler, b.s., limperos, r.j., pokabla, c.m., delucia, a.l., 1999. resveratrol inhibition of herpes simplex virus replication. antivir. res. 43, 145-155]. after examining numerous cellular factors, we report that resveratrol suppresses nf-kappab (nf-kappab) activati ... | 2006 | 16876885 |
| [perianal herpetic ulcers in a patient with previously undiagnosed human immunodeficiency virus]. | 2006 | 16978553 | |
| the microenvironment of vulvar skin in women with symptomatic and asymptomatic herpes simplex virus type 2 (hsv-2) infection. | it is not known why some individuals infected with herpes simplex virus type 2 (hsv-2), experience frequent recurrences, while most of those infected have a completely silent infection. | 2006 | 16987263 |
| high incidence of genotypic variance between sequential herpes simplex virus type 2 isolates from hiv-1-seropositive patients with recurrent genital herpes. | we developed a polymerase chain reaction (pcr) method, based on strain-to-strain variation of dna repeats in the herpes simplex virus type 2 (hsv-2) genes us1 and us12, to genotype hsv-2 strains and determine the incidence and risk factors associated with hsv-2 superinfection in patients with recurrent genital herpes (rgh). forty-seven (92%) of 51 unrelated hsv-2 isolates could be distinguished. genotyping of sequential hsv-2 isolates showed a different genotype in all of the 11 human immunodefi ... | 2006 | 16991086 |
| primary treatment of acute retinal necrosis with oral antiviral therapy. | to explore the possibility of oral antiviral therapy in lieu of intravenous acyclovir for treating acute retinal necrosis (arn), a necrotizing retinopathy caused by herpes simplex virus type 1 or 2 or by varicella zoster virus. | 2006 | 16996614 |
| 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. synthesis and antiviral activity of all stereoisomers1. | all stereoisomers of adenine and guanine methylene-3-fluoromethylenecyclopropane analogues of nucleosides 9a, 9b, 10a, 10b, 11a, 11b, 12a, and 12b were synthesized and their antiviral activities were evaluated. a highly convergent approach permitted the synthesis of all these analogues using a single intermediate 15. reaction of aldehyde 13 with fluorotrichloromethane and tri-n-butylphosphine gave fluoroalkenes 14a+14b (83:17). addition of carbene derived from ethyl diazoacetate gave cyclopropan ... | 2006 | 17004726 |
| induction of innate immunity against herpes simplex virus type 2 infection via local delivery of toll-like receptor ligands correlates with beta interferon production. | toll-like receptors (tlrs) constitute a family of innate receptors that recognize and respond to a wide spectrum of microorganisms, including fungi, bacteria, viruses, and protozoa. previous studies have demonstrated that ligands for tlr3 and tlr9 induce potent innate antiviral responses against herpes simplex virus type 2 (hsv-2). however, the factor(s) involved in this innate protection is not well-defined. here we report that production of beta interferon (ifn-beta) but not production of ifn- ... | 2006 | 17005672 |
| quantification of poly(i:c)-mediated protection against genital herpes simplex virus type 2 infection. | alternative strategies for controlling the growing herpes simplex virus type 2 (hsv-2) epidemic are needed. a novel class of immunomodulatory microbicides has shown promise as antiherpetics, including intravaginally applied cpg-containing oligodeoxynucleotides that stimulate toll-like receptor 9 (tlr9). in the current study, we quantified protection against experimental genital hsv-2 infection provided by an alternative nucleic acid-based tlr agonist, polyinosine-poly(c) (pic) (tlr3 agonist). us ... | 2006 | 17005677 |
| prevalence of herpes simplex virus types 1 and 2 among children and adolescents attending a sexual abuse clinic. | children and adolescents with a history of sexual abuse are at risk for acquiring herpes simplex virus (hsv) type 2. we evaluated the prevalence of hsv-1 and hsv-2 and the usefulness for this population of 2 commercially available tests. | 2006 | 17006285 |
| multiphasic encephalomyelitis in a patient with recurrent herpes simplex type 2 meningitis. | we here describe a patient with a history of recurrent hsv-2 meningitis who had been free from symptoms for almost 20 y when he developed an acute encephalomyelitis. the clinical course laboratory and radiological findings support an acute multiphasic disseminated encephalomyelitis induced by a recurrent hsv-2 infection. | 2006 | 17008246 |
| chlamydia trachomatis and herpes simplex virus 2 infection in vulvar intraepithelial neoplasia associated with human papillomavirus. | the role of viral and bacterial co-infection is stressed in vin. a view that vin is a sexually transmitted disease made the area of research larger and stimulated scientists to seek other sexually transmitted factors, among which chlamydia trachomatis and herpes simplex are frequently examined. | 2006 | 17009637 |
| antiviral sulfated polysaccharide from navicula directa, a diatom collected from deep-sea water in toyama bay. | a sulfated polysaccharide named naviculan was isolated from a diatom, navicula directa (w. smith) ralfs, collected in deep sea water from toyama bay. the polysaccharide consisted of fucose, xylose, galactose, mannose, rhamnose and sulfate with an apparent molecular weight of 220000. it showed antiviral activities against herpes simplex viruses type 1 and 2, and influenza a virus with selectivity indices (cc50/ic50) of 270, 510 and 32, respectively. naviculan also showed an inhibitory effect on c ... | 2006 | 17015966 |
| the growth compromised hsv-2 mutant deltarr prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures. | we have previously shown that the hsv-2 anti-apoptotic protein icp10pk is delivered by the replication incompetent virus mutant deltarr and prevents kainic acid (ka)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. the present studies used deltarr and the icp10pk deleted virus mutant deltapk to examine the mechanism of neuroprotection. deltarr-infected neuronal cells expressed a chimeric protein in which icp10pk is fused in frame to lacz ... | 2006 | 17020750 |
| recurrent benign lymphocytic meningitis. | recurrent benign lymphocytic meningitis is a recurring, typically innocuous, painful form of aseptic meningitis. this syndrome is associated with transient neurological symptoms in one-half of afflicted patients. the causative agent is usually herpes simplex virus type 2, which can be confirmed by detection of viral dna in the cerebrospinal fluid using polymerase chain reaction. clinical disease resolves spontaneously; however, acyclovir, valacyclovir, and famciclovir have been administered to s ... | 2006 | 17029141 |
| characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients. | although cytomegalovirus (cmv) disease is a severe complication among immunocompromised patients, its cutaneous features have not been frequently reported. as herpes simple virus (hsv) infection commonly develops in cmv skin lesions, a study is needed on the pathogenetic role of cmv in cutaneous lesion formation. | 2006 | 17034528 |
| five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs. | in 1997-1998, the pharmacological cyclin-dependent kinase (cdk) inhibitors (pcis) were independently discovered to inhibit replication of human cytomegalovirus, herpes simplex virus type 1 and hiv-1. the results from small clinical trials against cancer were then suggesting that pcis could be safe enough to be used clinically. it was thus hypothesized that pcis could have the potential to be developed as novel antivirals targeting cellular proteins. consequently, antiviral chemistry & chemothera ... | 2006 | 17249245 |
| prevalence of sexually transmitted infections in female sex workers in athens, greece - 2005. | there is little data on the prevalence of stis in female sex workers, greek and immigrants, working in athens, greece, since most of them work without any form of official license. our aim was to establish the prevalence of stis in asymptomatic legal greek and immigrant female sex workers in athens, greece. the study involved an evaluation of gonococcal and chlamydial infection, early infectious syphilis, hiv infection, hsv-2 infection, hepatitis b and c in 299 female sex workers who applied for ... | 2006 | 17229607 |
| [herpes simplex virus vaccine studies: from past to present]. | the dramatical increase in the prevalence of herpes simplex virus (hsv) infections and the significant physical and psychosocial morbidity of hsv type 2 infections, generate the need for an efficacious hsv vaccine. the most important properties of hsvs that should be targeted for a successful vaccine are neuronal invasion, latency and reactivation in spite of specific host immune responses. the major expectation for an ideal hsv vaccine candidate is to induce sterilizing immunity, which must be ... | 2006 | 17205702 |
| [effect of huangbai liquid on expression of human beta-defensin-2 mrna in skin lesions of patients with recurrent genital herpes]. | to investigate the expression of human beta-defensin-2 (hbd-2) mrna in skin lesions of patients with recurrent genital herpes (rgh) and the effect of huangbai liquid (hl) on it. | 2006 | 17205827 |
| [genital herpes]. | 2006 | 17190019 | |
| [serologic examination for childhood herpes simplex virus infection]. | this study was designed to investigate the value of serologic examination in the diagnosis of childhood herpes simplex virus (hsv) infection. | 2006 | 17178039 |
| men who have sex with men and transgenders in mumbai, india: an emerging risk group for stis and hiv. | men who have sex with men and transgenders are an important risk group for sexually transmitted infections (stis) and human immunodeficiency virus (hiv). they have risky sexual behaviors but low risk perception. | 2006 | 17179617 |
| famciclovir: a review of its use in herpes zoster and genital and orolabial herpes. | famciclovir (famvir) is the oral prodrug of penciclovir, an agent that has demonstrated antiviral activity against herpes simplex viruses, type 1 (hsv-1) and 2 (hsv-2) [which cause orolabial and/or genital herpes simplex], and against varicella zoster virus (vzv) [a reactivation of which leads to herpes zoster]. famciclovir has efficacy similar to that of aciclovir (in immunocompetent or immunocompromised patients) or valaciclovir (in immunocompetent patients) in the treatment of herpes zoster, ... | 2006 | 17181386 |
| disseminated herpes simplex infection with cystic fibrosis: a case report. | a 6 months old female infant presented with history of fever, cough and severe respiratory distress. there was past history of recurrent attacks of pneumonia. she succumbed to the illness after a hospital stay of 7 days. postmortem revealed morphological evidence of cystic fibrosis along with herpes simplex infection of liver and adrenals. the co-existence of disseminated herpes simplex infection and cystic fibrosis is very rare. | 2006 | 17183874 |
| unilateral twin ectopic pregnancy in a patient with a history of multiple sexually transmitted infections. | the incidence of unilateral twin ectopic pregnancy is a rare condition. several factors increase the risk of ectopic pregnancy, the most important of which is pelvic inflammatory disease, followed by operative trauma, congenital anomalies, tumors, and adhesions resulting in anatomically distorted fallopian tubes. we present a case of a woman with a history of four confirmed sexually transmitted infections (stis) including chlamydia trachomatis, neisseria gonorrhoeae, herpes simplex virus 2, and ... | 2006 | 17485794 |
| stability of lyophilised specimens for the molecular detection of viral dna/rna. | the range of nucleic acid-based technologies for the molecular detection of pathogens has grown rapidly in recent years. the influx of new testing methods into the clinical laboratory, demands for evaluation and standardisation of methods, interpretation of results and evaluation of laboratory performance have highlighted the need for internal and external quality assessment (eqa) systems more than ever before. external quality assessment panels demand reproducible, stable specimens of consisten ... | 2006 | 16024290 |
| seroprevalence of herpes simplex virus 1 and 2 and correlates of infection in israel. | the prevalence of infections with herpes viruses 1 and 2 (hsv1 and hsv2) have significantly changed in the developed countries during the last three decades. this study provides up-to-date estimates of hsv-1 and hsv-2 seroprevalence and information on the correlates of infection in a representative sample of the israeli population. | 2006 | 16213591 |
| deficit schizophrenia: association with serum antibodies to cytomegalovirus. | patients with deficit schizophrenia differ from nondeficit patients with schizophrenia relative to several neurobiological correlates and relative to the risk factors of family history and season of birth. exposure to human herpesviruses is a possible risk factor for schizophrenia. we hypothesized that there would be deficit/nondeficit difference in the prevalence of serum antibodies to human herpesviruses. | 2006 | 16166610 |
| anti-viral activity of the extracts of a kenyan medicinal plant carissa edulis against herpes simplex virus. | herpes simplex virus (hsv) infection is a major opportunistic infection in immunosuppressed persons. it is therefore a serious disease in high hiv/aids prevalence areas as in sub-saharan africa where infections due to hsv have risen significantly. the development of resistant strains of hsv to the available drugs for infection management, as is evident in the first drug of choice acyclovir, has further compounded this situation. there is therefore an urgent need to identify and develop new alter ... | 2006 | 16198524 |
| effect of immunization with herpes simplex virus type-1 (hsv-1) glycoprotein d (gd) plus the immune enhancer gpi-0100 on infection with hsv-1 or hsv-2. | these studies were performed to determine the effects of gpi-0100, a semi synthetic quillaja saponin analog, formulated with herpes simplex virus type-1 (hsv-1) glycoprotein d (gd) on immunity to hsv. skh-1 hairless mice, used as a model of herpes labialis, inoculated with hsv-1 results in facial lesions, virus replication and mortality. mortality rates, lesion scores and viral titers were significantly reduced in skh-1 mice immunized with gd/gpi-0100 prior to cutaneous inoculation with hsv-1 an ... | 2006 | 16288820 |
| development of the loop-mediated isothermal amplification method for rapid detection of cytomegalovirus dna. | cytomegalovirus (cmv) loop-mediated isothermal amplification (lamp) was performed on dna extracted from cmv (ad-169)-, herpes simplex virus (hsv) 1 (kos)-, hsv-2 (186)-, varicella-zoster virus (oka-vaccine)-, human herpesvirus (hhv)-6 a (u1102)-, hhv-6 b (z29)-, and hhv-7 (rk)-infected cells. although amplified cmv demonstrated typical ladder patterns, no lamp product was detected in reactions performed with other viral dnas. the sensitivity of the cmv lamp was 500 copies/tube, as determined by ... | 2006 | 16289345 |
| anti-herpes virus activity of dunbaria bella prain. | the herpes inhibitory effect of dunbaria bella prain (fabaceae), a thai medicinal plant traditionally used to treat viral infections was investigated. using a bioassay-guided fractionation procedure, tertiary fractionation of a dichloromethane-methanol plant extract afforded a partially purified fraction (fr.372) equally active against replication of herpes simplex virus (hsv) types 1 and 2. the 50% inhibitory concentration determined by a viral yield-inhibition assay was 1.21-1.25 microg/ml and ... | 2006 | 16298095 |
| herpes simplex virus and human papillomavirus infection in cervical disease in argentine women. | the aim of the present study was to determine that prevalence of herpes simplex virus (hsv) type 1 and 2 in cervical samples from argentine women and to assess the role of hsv-2 in cervical cancer. a sample of 79 normal and 200 neoplastic cervical tissues (35 invasive cervical carcinomas, 75 high-grade squamous intraepithelial lesions, 79 low-grade squamous intraepithelial lesions and 11 abnormal squamous cells of undermined significance) was analyzed for herpes simplex and human papillomavirus ... | 2006 | 16306783 |
| an sirna-based microbicide protects mice from lethal herpes simplex virus 2 infection. | herpes simplex virus 2 (hsv-2) infection causes significant morbidity and is an important cofactor for the transmission of hiv infection. a microbicide to prevent sexual transmission of hsv-2 would contribute substantially to controlling the spread of hiv and other infections. because rna interference (rnai) provides effective antiviral defence in plants and other organisms, several studies have focused on harnessing rnai to inhibit viral infection. here we show that vaginal instillation of smal ... | 2006 | 16306938 |
| hydrocephalus in herpes simplex type 2 meningitis. | a 34-year-old woman presented to hospital with symptoms of meningitis, later confirmed to be due to herpes simplex virus type 2. she developed hydrocephalus on day 2 of her admission. we describe the first case of hydrocephalus associated with herpes simplex type 2 meningitis in an adult. | 2006 | 16313967 |
| head and neck cancer associated with herpes simplex virus 1 and 2 and other risk factors. | we investigated whether herpes simplex viruses, hsv-1 and hsv-2, are cofactors of head and neck cancer (hnc) in association with tobacco, alcohol, or hpv-16 infection. the study included 164 hnc cases and 295 controls. serologic tests were used to distinguish hsv-1 and hsv-2. antibodies to anti-vlp hpv-16 and hpv-16 e6 and e7 were evaluated by elisa. after adjusting for age, tobacco, alcohol use, and number of sexual partners, risk of cancer was not significantly increased in those with hsv-1 [a ... | 2006 | 16324878 |
| pro 2000 gel inhibits hiv and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial. | microbicides used to prevent the transmission of human immunodeficiency virus (hiv) are advancing to clinical trials on the basis of activity observed in vitro and in animal models. however, no data demonstrate activity of microbicides after application in humans. this study was designed to determine the antiviral activity in cervicovaginal lavage (cvl) samples collected after intravaginal application of 0.5% pro 2000 gel (indevus). | 2006 | 16323128 |
| herpes simplex virus 2 infection increases hiv acquisition in men and women: systematic review and meta-analysis of longitudinal studies. | to estimate the sex-specific effect of herpes simplex virus type 2 (hsv-2) on the acquisition of hiv infection. | 2006 | 16327322 |
| reducing hiv-1 transmission through prevention strategies targeting hiv-1-seropositive individuals. | prevention efforts for hiv-1 have traditionally focused on those at risk for acquiring the virus. recently, there has been growing interest in directing prevention efforts towards hiv-1-seropositive individuals, who are seeking care in increasing numbers as a result of improving access to antiretroviral therapy in resource-limited countries. biomedical interventions aimed at reducing the spread of hiv-1 by targeting those at risk for transmitting the virus will be guided in part by an understand ... | 2006 | 16332729 |
| treatment of intravaginal hsv-2 infection in mice: a comparison of cpg oligodeoxynucleotides and resiquimod (r-848). | the mammalian innate immune system recognizes pathogens via a series of pattern-recognition receptors such as the toll-like receptors (tlr) that interact with pathogen-associated molecular patterns (pamps) and lead to the rapid activation of innate immune cells. in this study, we compared the efficacy of cpg odn (a tlr9 agonist) and resiquimod (r-848; a tlr7/8 agonist) for topical immunoprophylaxis or immunotherapy of vaginal herpes simplex virus type 2 (hsv-2) infection in mice. efficacy agains ... | 2006 | 16377001 |
| etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. | the purpose of the present study was to determine pathogens and behaviors associated with nongonococcal urethritis (ngu) and the usefulness of the urethral smear in predicting the presence of pathogens. | 2006 | 16388480 |
| the receptor-binding region of human apolipoprotein e has direct anti-infective activity. | the apoe genotype has a uniquely strong influence on the outcome of viral infection. the mechanism is unknown, although one possibility is direct inhibition of viral entry into cells. | 2006 | 16388493 |