Publications

[serum levels of thyroxine (t4), triiodothyronine (t3) and thyrotropic hormone (tsh) in chronic kidney insufficiency].	the authors studied the serum level of t3, t4 and tth in 30 euthyroid patients with chronic renal insufficiency (cri), distributed in three groups of 10 patients. i group includes patients with cri ii and iii stage without dialysis treatment, patients with cri are included in the ii group, being under hemodialysis treatment from 5 to 12 months, and in iii group--patients dialized three and more years. low average values of t3--0.65 mg/ml were established only in the first group; in 8 patients, o ...	1980	7385804
t4 degradation rate and plasma levels of tsh and thyroid hormones in ten young bulls during feeding conditions and 48 h of starvation.	the effect of starvation on thyroid hormones was studied during a starvation period of 48 h in 10 young bulls. mean thyroxine degradation rate decreased from k/day 0.32 during feeding to 0.23 during fasting. mean plasma concentration of t4 decreased to 75% of normal, and it was calculated that the mean thyroxine secretion rate during the starvation period was 24% of normal. plasma concentration of free thyroxine decreased to 54% of normal, indicating that the concentration of binding protein was ...	1980	7386113
thyroid hormone levels related to energy and nitrogen balance during weight loss and regain in adult sheep.	caloric deprivation (feeding 50 and 25% of the original maintenance requirement for 126 days), followed by overnutrition (feeding 133 and 200% of the original maintenance requirement) for 37 days, were induced in 7 adult sheep. before and after the periods of undernutrition and after overnutrition the animals were fasted (total energy withdrawal) for 5 days. energy- and nitrogen-balances were determined and related to concentrations of thyroxine (total: t4; free: ft4), 3,5,3'-triiodothyronine (t ...	1980	7386114
t4, t3 and reverse t3 in the plasma of rats during the first 3 months of life.	a very sensitive radioimmunoassay for reverse t3 in rat plasma is described. the concentrations of t4, t3 and reverse t3 in plasma of male and female rats were determined during the first 3 months of life. t4 concentrations reached a maximum value of 5.2 +/- 0.7 microgram/100 ml (mean +/- sd) when the rats were about 16 days old. as of day 28 the average serum t4 was approximately 4 microgram/100 ml. concentrations of t3 reached a maximum value of 168 +/- 34 ng/100 ml (mean +/- sd) during the 16 ...	1980	7386115
eeg spectral analysis in schizophrenia.	four channels of eeg (t4-t6, p4-02, t3-t5, p3-01) were recorded from several groups of control subjects and schizophrenia patients on analogue tape. they were later digitized and analysed by computer; power spectra were computed for 30 second epochs of eeg per channel; eyes closed, eyes open. no difference between normal controls and neurotic in-patients was apparent. an acute schizophrenic group had less alpha power, this change being confined largely to the temporal areas. a chronic outpatient ...	1980	7388249
[fundamental and clinical studies on the measurement of serum thyroxine by phadebas t4-ria kit (author's transl)].		1980	7389165
isolation of human spontaneous killer lymphocytes by bacterial adherence.	human lymphocyte subpopulations (b, t1, t2, t3, and t4 our denomination) have been identified previously by bacterial adherence and differences between them in mitogen responses and specific cytotoxic activity have been found. in this study another aspect has been investigated in order to find functions associated with these subpopulations, namely the spontaneous killing (sk) ability. freshly isolated human peripheral blood lymphocytes (pbl) were separated into adherent and non-adherent cells fo ...	1980	7389207
age- and sex-associated differences in the relationship of serum hexosaminidase and t4 levels in human neonates.		1980	7389625
effect of propylthiouracil on nycthemeral and sex related variation of plasma tsh in rats.	studies of the effect on feedback mechanisms in nycthemeral fluctuation of plasma tsh and of its sex-related variation were carried out on normally fed (purina) and propylthiouracil (ptu) treated rats. plasma tsh concentration of purina fed rat was significantly higher in males than in females (m = 96 +/- 14, f = 49 +/- 3 microunits/ml, p less than 0.01). plasma t4 concentration also showed a high tendency in males compared to females (m = 7.4 +/- 0.5, f = 5.8 +/- 1.0 micrograms/dl, 0.05 less th ...	1980	7389671
the early follow-up of 131i-treatment of thyrotoxicosis.	no general agreement exists concerning the optimal time for the first control of patients treated with 131i for thyrotoxicosis. ten consecutive cases were followed clinically, and current laboratory thyroid tests were frequntly performed during a 14 week period to point out the optimal control time and the best setup of control parameters for such patients. it is concluded that clinical examination, supplied with t4, t3, t3-test, and tsh determinations 12--14 weeks after therapy seems rational a ...	1980	7389719
"t4-toxicosis": a source of error in the diagnosis of thyrotoxicosis.		1980	7390745
pilot study for congenital hypothyroidism, preliminary report.	preliminary results of a pilot study on congenital hypothyroidism performed on 8,025 newborns in italy over a 10-month period are reported. the determination of both t4 and tsh on dried blood, spotted on filter paper, as screening procedure at day 3-5 of life revealed three cases of primary hypothyroidism and one case of hypo-thyroxin-binding-globulinemia (hypo-tbg-emia). the diagnosis of primary hypothyroidism was established on the basis of low t4 and high tsh levels in two of the three cases; ...	1980	7391524
effect of tsh stimulation on serum thyroglobulin in metastatic thyroid cancer.	thyroglobulin (tg) is a glycoprotein which has been found to be produced by almost all nonmedullary thyroid cancers, and is present in elevated levels in the serum of most patients with metastatic thyroid cancer. it has long been a clinical impression that many metastatic thyroid cancers are "responsive" to tsh suppression as manifested by a decrease in the size and/or symptoms of the tumor. five athyroid patients with metastatic thyroid cancer were studied to determine the effect of tsh stimula ...	1980	7392641
adrenal, thyroid, and rectal temperature responses of pinealectomized cockerels to different ambient temperatures.	pinealectomized (px), sham-operated (pn), and control (c) cockerels were randomly assigned to three ambient temperatures (7, 23, or 37 c) at eight weeks of age. rectal temperature (tr) and blood were taken from birds either at mid-photophase or mid-scotophase (12l:12d) on five different days of the exposure period (0, 4, 8, 12, and 16 days). after 16 days of exposure to different ambient temperatures (ta), birds were killed and their adrenal and thyroid glands removed. serum t3 and t4 were measu ...	1980	7393843
production of severe iodine deficiency in sheep using a prepared low-iodine diet.	extensive tests on dietary materials suitable for ingestion by sheep have led to the preparation of an appropriate diet which, when fed to the sheep, caused severe iodine deficiency. the deficiency was manifested by daily urinary excretion values which fell to levels of less than 20 micrograms iodine and by thyroxine (t4) and triiodothyronine (t3) concentrations in blood plasma which were reduced from more than 90 and 1.80 nmol/l to the low levels of less than 2.58 and 0.31 nmol/l respectively. ...	1980	7396808
[fundamental study of immo phase t4 by radioimmunoassay using solid phase method (author's transl)].		1980	7398102
the advantage of the use of echocardiographic evaluation in hypothyroid patients.	authors examined 10 patients with untreated myxoedema. the disease lasted at least one year in seven cases. the etiology of disease was autoaggressive thyroiditis in 9 cases and was diagnosed by a high titre of antibodies against thyroglobulin. the levels of t4 and t3 were low in all cases, level of tsh was elevated. the mean level of t4 was 0.91 microgram/dl, of t3 43.5 ng/dl. the level of tsh was over 96 microu/ml in 7 cases, in rest over 54 microu/ml. in all cases echo examination was done: p ...	1980	7398589
conversion of thyroxine to triiodothyronine and reverse triiodothyronine in human placenta and fetal membranes.	conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) and reverse 3,3',5'-triiodothyronine (rt3) was measured in vitro in human placenta and fetal membranes. t4 (5 micrograms/ml) was incubated in 0.15 mol/l phosphate buffer with tissue homogenates for 2 h at 37 degrees c, and the t3 and rt3 generated were determined in ethanol extract using ria methods. the placenta and chorion homogenates converted more t4 to t3 than to rt3; the placenta was more active than the chorion. in both tissues ...	1980	7399397
circular dichroism studies on the interaction between human serum albumin and thyroxine.	the cotten effects induced by the interaction of thyroxine (t4) with human serum albumin (hsa) have been examined at various molar ratios of t4 to hsa. the results suggested the following three distinct modes of interaction, depending on the molar ratio (n). 1. the first mode of interaction appeared at n=0-1. a large difference cd amplitude attributable to t4 was observed in the region between 280 nm and 325 nm. this suggests that the t4 molecule binds tightly to a highest affinity site of hsa. ...	1980	7400119
prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects.	a 48-h dopamine (da) infusion (5-7.5 microgram/kg . min) given to six healthy euthyroid males resulted in a suppression of thyroidal iodine release and serum tsh by 44 +/- 3% (p less than 0.01), serum t3 by 9 +/- 2% (p less than 0.01), and serum t4 by 5 +/- 1% (p less than 0.05) below baseline levels, without a significant change in serum rt3 levels. in critically ill patients receiving da (2-21 microgram/kg . min) for treatment of shock, serum tsh values and t4 production rates were decreased 6 ...	1980	7400302
nodal involvement as a prognostic indicator in patients with prostatic carcinoma.	between 1969 and 1976, 92 patients with proved prostatic carcinoma in stages t0 and t4 underwent pelvic lymphadenectomy. median followup has been 43 months. all patients had normal serum acid phosphatase levels and no clinical evidence of metastases as determined by physical examination, bone scans and metastatic bone surveys. pelvic lymph node metastases were noted in 32 cases. radical prostatectomy was done in 34 cases and 45 patients received radiotherapy, 11 of whom had 125iodine seeds impla ...	1980	7401236
transcriptional control of two gene subclusters in the trna operon of bacteriophage t4.	in bacteriophage t4 dna, transcription units recognized in vitro by host rna polymerase consist of promotor-proximal 'immediate early' (ie) genes and promotor-distal 'delayed early' (de) genes separated from each other by rho-dependent transcription terminators. in vivo, the transition from ie to de transcription requires phage-specific protein synthesis and can be prevented by chloramphenicol (cam). most of the information about ie/de transition has been obtained by hybridizaton analyses of mix ...	1980	7402325
[bone metastases of prostatic cancer in relation to tumor size and grade of malignancy (author's transl)].	in 153 patients with prostatic cancer total body bone scintigraphy was performed. forty six patients showed bone metastases while there was no evidence of skeletal involvement in 101 cases. our results show that the tendency of bone metastases increases when low differentiated type of malignancy is present: patients with low grade malignancy (g1) showed bone metastases in 7.3%, with middle grade malignancy (g2) in 40%, and with high grade malignancy (g3) in 38.5%. we were also able to establish ...	1980	7402942
[problems of treatment with thyroid hormones. thyroxin monotherapy or a t3/t4 combination preparation?].	at the instance of t3- and t4-measurements of the daily profile in the serum after the application of triiodothyronine and the usual t3/t4-combination preparations is referred to the unphysiologically high t3-peaks 2 to 4 hours after the application depending on the proportion of triiodothyronine. the three distributed all over the day doses of e.g. thyreotom do not sufficiently smooth such undulations. the lacking triiodothyronine serum peaks after application of pure thyroxin as a bolus confir ...	1980	7405318
behavioral dysfunction in hyperthyroidism. improvement with treatment.	we measured behavioral dysfunction in hyperthyroid patients to determine if improvement occurred with therapy. the sickness impact profile (sip), an interview designed to measure sickness-related behavior, was administered to 14 hyperthyroid patients on initial diagnosis and at intervals during treatment. all patients received medical therapy (propranolol hydrochloride, propylthiouracil, and/or radioactive iodine) and showed both biochemical improvement as measured by adjusted serum thyroxine (t ...	1980	7406617
t4-throid storm in pernicious anemia.	a 32-year-old woman first had thyrotoxicosis and severe pernicious anemia (pa) in 1975. the initial serum thyroxine (t4) level, 14.5 microgram/dl, rose to 29.2 microgram/dl, with no other therapy except cyanocobalamin injection and blood tranfusions. she again had thyroid storm and pa in 1978. the serum t4 level was only slightly elevated, but the triiodothyronine (t3) level was normal. she received therapy for both diseases and recovered. four months later, with a normal hematocrit reading, thy ...	1980	7406625
[screening for neonatal hypothyroidism by estimation of t4 (author's transl)].	over a 21 month period simultaneous screening for phenylketonuria and hypothyroidism by estimation of t4 was undertaken in 139,730 newborns. tsh was estimated in those with lowest t4 values. 22 cases of primary hypothyroidism, 26 with tbg deficiency and 8 with transient hypothyroidism were detected. there were a relatively high number of false positive results which should in theory be close to 5% (because the cut off fevel for t4 was 1.6 s.d. below the mean). this was reduced at 3.3% on the sec ...	1980	7406637
[carcinoma of the breast: diagnosis of sub-clinical bone metastases. predictive value of isotope bone scan (author's transl)].	the possibility of drawing a distinction between two groups with or without bone metastases is of fundamental importance in the determintion of management. with this in mind, isotope bone scan using tc 99 was performed routinely in 99 cases of locally advanced non-metastatic carcinoma of the breast. amongst 121 "operable" (t1, t2, t3, n0, n1a) carcinomas, 4 (3%) had a positive scan. of these 4 cases, 3 showed evidence of bone metastases within one year, in 3 of which the site was not the same as ...	1980	7407429
d-propranolol and dl-propranolol both decrease conversion of l-thyroxine to l-triiodothyronine.	the effects of propranolol (dl-propranolol) and d-propranolol on thyroid hormone metabolism were studied in six euthyroid volunteers receiving l-thyroxine (t4) and six hypothyroid patients receiving t4 replacement. d-propranolol as well as propranolol decreased l-triiodothyronine (t3) concentrations and the ratio of t3 to t4 in the euthyroid subjects, and d-propranolol decreased these variables in the subjects with hypothyroidism (propranolol was not given to this group). it is concluded from th ...	1980	7407482
biochemical and immunological investigations on hypothyroidism in dogs.	circulating antibody titers (1:20 to 1:2560) against thyroglobulin were demonstrated in 48% of pet dogs with hypothyroidism by the chromic chloride passive hemagglutination test. four of six dogs with acanthosis nigricans (1:20) and one of six male dogs with hyperestrogenism (1:40) had low titers of antibody against thyroglobulin whereas clinically normal pet dogs and dogs with other selected endocrinopathies (hypoadrenocorticism, cortisol-excess, diabetes mellitus) or obesity were consistently ...	1980	7407688
international survey of the radioimmunological measurement of serum reverse triiodothyronine.	an international survey was conducted to study the performance of the radioimmunoassay of serum reverse triiodothyronine (rt3). eight laboratories were provided with 10 serum samples containing several concentrations of rt3 and thyroxine (t4). each laboratory also obtained the same batch of pure rt3. t4 and rt3 were measured by all participants in these samples. half of the investigators routinely correct their data for t4 cross-reactivity. the results demonstrate that the performance of the rt3 ...	1980	7408194
the irradiated radical neck dissection in squamous carcinoma: a clinico-pathological study.	a preliminary clinico-pathological survey is presented of radical neck dissections from 50 patients with advanced (t3, t4) squamous carcinomas of the head and neck, previously treated by irradiation and combination chemotherapy. the total yield of lymph nodes (1411) from these dissections was high--mean of 28 nodes/dissection, range 8-60; the proportion of nodes containing metastatic carcinoma was low--100 (7%)--with only 1 or 2 nodal masses/dissection in most instances. the involved nodes tende ...	1980	7408226
enzyme kinetic and substrate-binding studies of the thyroxine to 3,5,3'-triiodothyronine converting enzyme in the rat liver microsomal fraction.	the conversion of t4 to t3 was studied in the rat liver microsomal fraction. a mean vmax of 0.11 pmol t3 produced per mg microsomal protein/min and a mean apparent km of 2.1 mum t4 were found. an approximation to the real km for the experimental conditions used was obtained by applying free instead of total t4 as the substrate concentration. thus, the km was found to be 9.7 nm free t4, and changes of km with different amounts of microsomal protein added were not detected. rt3 was found to be a c ...	1980	7408767
evidence for circadian variations in serum thyrotropin, 3,5,3'-triiodothyronine, and thyroxine in the rat.	we previously observed that under a 12-h light, 12-h dark schedule (lights off at 1900 h), male sprague-dawley rats showed a circadian rhythm for serum tsh with a zenith near midday. in the present work we further characterized the serum tsh rhythm by appropriate mathematical analysis. the peak of serum tsh occurred at 1130 +/- 0105 h (mean of five experiments), with an amplitude of 0.2 +/- 0.1 microgram/ml, while the tsh level was minimum at the beginning of the dark period; the period of the t ...	1980	7408771
the influence of thyrotropin and growth hormone on the thyroid gland in the hereditary dwarf mouse: a morphometric study.	snell-type dwarf mice were injected with tsh, gh, or both hormones together for 6 days. gh induced an increase in body weight but not in the weight of the thyroid gland itself; on the contrary, tsh caused an increase in the weight of the thyroid but no increase in body weight. after tsh injection, the relative volume of the thyroid parenchyme was enhanced by 45% compared to that in untreated dwarf mice, and the radius of the follicles and follicular lumina increased by 50% and 48%, respectively. ...	1980	7408772
secretion of 3,3'-diiodothyronine by the perfused canine thyroid isolated in situ.	previous studies employing perfused dog thyroid lobes have shown that thyroidal secretion is modulated by intrathyroidal deiodination of t4 to t3 and rt3. to characterize further the intrathyroidal iodothyronine-deiodinating processes 3,3'-diiodothyronine (3,3'-t2) and t4 were measured in hydrolysate and effluent from isolated dog thyroid lobes during single passage perfusion with a synthetic hormone-free-medium. in five experiments the concentrations in effluent from unstimulated thyroid lobes ...	1980	7408779
a possible function of thiols, including glutathione, as cofactors in the conversion of thyroxine to 3,3',5-triiodothyronine in rat liver microsomes.	thyroxine (t4) is known to be converted to triiodothyronine (t3) in rat liver microsomes. an endogenous stimulatory factor for the conversion of t4 to t3 was identified as reduced glutathione (gsh) by sephadex g-15 gel chromatography of rat liver extract. the production of t3 in rat liver microsomes was maximally stimulated above a gsh concentration of 4mm, and an approximately 5-fold stimulation was attained. this degree of stimulation was approximately 10 time less than that observed with dith ...	1980	7408784
[the effect of glucose and 2-deoxy-d-glucose on the monodeiodination of thyroxine by human skin fibroblasts in culture (author's transl)].	the effect of glucose and 2-deoxy-d-glucose on the extrathyroidal monodeiodination of thyroxine (t4) to 3, 5, 3'-triiodothyronine (t3) and 3, 3', 5'-triiodohyronine (reverse t3;rt3) was studied in human skin fibroblasts in culture. when the fibroblasts were maintained in glucose-free eagle's mem fortified with 3% fetal calf serum, intracellular t4 was unchanged, intracellular t3 decreased, and intracellular rt3 markedly increased as compared with those in eagle's mem containing 3% fetal calf ser ...	1980	7409271
[the method of t4 radioimmunoassay using filter paper blood samples and its application for the early detection of neonatal hypothyroidism (author's transl)].	we examined the method of radioimmunoassay of the disc t4 (dried blood spot t4) for the purpose of mass screening of neonatal hypothyroidism and tried the parallel assay of t4 and tsh in dried blood spotted on filter paper at the fifth day of life, and we compared the results. by changing the volumes of t4 antibody and t4 antigen solutions, it is possible to measure thyroxine using two discs 3mm in diameter. disc t4 values obtained in 45 unknown samples by this method were in good correlation wi ...	1980	7409272
the renal clearance of thyroid hormones in the isolated perfused rat kidney.	the isolated perfused rat kidney was used to study renal handling of thyroid hormones. substrate enriched protein free perfusates were chosen which allowed the kidneys to perform a normal glomerular filtration rate of 1.1 ml/g kidney x min and enabled accurate estimation of filtered load and tubular handling of free thyroid hormones without interference from the presence of hormone binding substances. under these conditions we found a high tubular reabsorption capacity for both t3 and t4. this r ...	1980	7409740
squamous-cell carcinoma of the floor of the mouth.	among the histologic parameters described by jakobsson, only the stage (depth) of invasion appears to be of value in predicting lymph node metastases. early carcinomas of the fom examined in our institution (t1 and some t2) grew in a superficial or horizontal manner and none developed metastases or local recurrence. larger neoplasms (some t2 and all t3 and t4) had extensive submucosal and deep soft tissue infiltration and a corresponding high frequency of regional lymph node metastases. t1 and t ...	1980	7410099
seasonal changes in the ultrastructure of the thyrotroph in the wookchuck (marmota monax) adenohypophysis.	throtrophs of the woodchuck anterior pituitary are described through the four seasons of the year. evidence of an increase in number and activity in the spring is presented. activity of the thyrotroph is seen to continue through the summer and decline in the autumn to quiescence during the hibernatory period of winter. the significance of these findings is discussed in relation to thyoid follicular cell morphology, serum t3 and t4 levels and the physiological activities of the animal. high level ...	1980	7410194
influence of thyroid status on dopaminergic inhibition of thyrotropin and prolactin secretion: evidence for an additional feedback mechanism in the control of thyroid hormone secretion.	serum tsh and prl concentrations were measured after the randomized oral administration of either metoclopramide, l-dopa, or placebo on 3 consecutive days to five patients with overt primary hypothyroidism (low serum total t4 and raised serum tsh) and to five patients with subclinical hypothyroidism (normal serum total t4 and raised serum tsh). in both groups there was a rise in serum tsh and prl concentrations after metoclopramide and a fall after l-dopa when compared with the effect of the pla ...	1980	7410535
thyroglobulin and thyroid hormone release after intravenous administration of bovine thyrotropin in man.	to elucidate the mechanism of thyroglobulin (tg) release in man, the effects of an iv injection of a submaximal dose of bovine tsh (btsh) on the serum levels of tg were compared with the effects on serum t3 and t4. after the administration of btsh, short term kinetics (0-4 h) were studied in eight subjects receiving 0.5 iu btsh and seven subjects receiving 1 iu btsh. serum tg did not significantly increase in either of the short term studies. by contrast, serum t3 increased significantly and lin ...	1980	7410536
assembly of bacteriophage t4 head-related structures. iv. isolation and association properties of t4 prehead proteins.		1980	7411605
free t4, free t3, and reverse t3 in critically ill, thermally injured patients.	a prospective study of thyroid function was performed in 25 thermally injured patients. these patients are divided into two groups. the first group contains five patients with greater than 50% burn size studied longitudinally during the first 15 days following thermal injury. significant suppression of serum concentrations of 3,5,3'-triiodothyronine (t3) and elevation of serum concentrations of 3,3',5'-triiodothyronine (rt3) were seen. the free thyroxine index and serum tsh concentrations remain ...	1980	7411659
serum reverse triiodothyronine (3,3',5'-l-triiodothyronine) in chronic renal failure.	serum reverse triiodothyronine (reverse t3), triiodothyronine (t3), thyroxine (t4) and thyrotropin (tsh) concentrations were determined by radioimmunoassay in end-stage chronic renal failure, hypothyroidism and control subjects. in advanced chronic renal failure serum reverse t3 was normal or elevated and serum t3 concentrations were frequently, and serum t4 occasionally, lowered. serum tsh was normal even where serum t3 and t4 concentrations were low. normal or elevated serum reverse t3 associa ...	1980	7412964
[early recognition of autonomous thyroid tissue by a combination of quantitative thyroid pertechnetate scintigraphy with the free t4 equivalent (author's transl)].	autonomously functioning thyroid tissue (aftt) of the circumscribed as well as the disseminated form was found with equal frequency and extent in eumetabolic patients under and over 40 years of age who live in an endemic goitre area. in an area of iodine deficiency this is the most frequent precondition for hyperthyroidism induced by iodine administration. a suspicion of aftt can be raised in 80% of still euthyroid patients by a combined evaluation of an equivalent to the free t4 (fte) and an eq ...	1980	7413438
the role of radiotherapy in the treatment of malignant tumors of the salivary glands.	treatment results in a group of 70 patients with salivary gland tumors were analyzed. prognosis appeared to correlate with both clinical stage and malignancy of tumors. in patients irradiated postoperativey because of nonradical operation, a higher 5-year survival rate was achieved than in patients after radical surgery. it is suggested that postoperative radiotherapy improves treatment results in patients with t2 and t3 lesions. in unresectable cases (t4) a 13% 5-year survival was achieved. in ...	1980	7414711
[state of the hypothalamo-hypophyseo-thyroid system in severe craniocerebral injuries].	the amount of the pituitary thyrotropic hormone and the thyroid hormones (t4, t3, ket) in the serum of 30 patients with severe craniocerebral trauma was studied in dynamics from the 1st and until the 30th day of the disease. marked disorders in the hypothalamo-hypophyseal-thyroid system were revealed in the form of hypersecretion of the thyrotropic hormone and profound inhibition of the thyroid function. both the transport-organic and the metabolic phase of metabolism of the thyroid hormones suf ...	1980	7415734
[discordance of total plasma l-triiodothyronine and l-thyroxine in thyroid diseases].	radioimmunoassay (ria) for plasma t3 has been proposed in the diagnosis of thyroid disease. 1 171 simultaneous determination (ria) of plasma thyrotropin-stimulating hormone (tsh), triiodothyronine (t3) and thyroxine (t4) have been performed in unselected patients under suspicion of a thyroid disease. 81.8% of the cases showed a good agreement between t3 and t4 levels. the remaining 18.2% can be divided into 6 groups: 1. high t3-normal t4 : 51% of the discrepancies: graves disease untreated (16%) ...	1980	7416706
processing of bacteriophage t4 trnas: an rnaase iii- strain contains a precursor for trnag1n and trnaleu.		1980	7417328
combination of external and interstitial irradiation in the primary management of breast carcinoma.	the authors treated 83 patients with carcinoma of the breast using a combination of external and interstitial irradiation at los angeles county--university of southern california medical center and southern california cancer center between february 1, 1974, and may 31, 1977. all 30 patients who had t1 and t2 lesions, and who were followed for a minimum period of 24 months (24-50 months) are clinically still free of disease. thirty-nine of 53 patients with t3 and t4 lesions, who were followed for ...	1980	7417936
[measurement of total t4 and free t4 by solid phase radioimmunoassay (author's transl)].		1980	7418240
[assessment of thyroid function by the phadebas t4 ria (author's transl)].		1980	7418247
[a study of the conversion of thyroxine to 3, 3', 5-triiodothyronine in the rat liver: the mechanism of stimulatory effects of thiols on t4 5'-deiodinase (author's transl)].		1980	7418927
[a clinical evaluation of the increased serum myoglobin: creatine phosphokinase and lactic dehydrogenase in patients with thyroid disorders (author's transl)].	since muscle dysfunction is frequently associated with a hypothyroid state, many clinical reports have indicated that serum enzyme activities derived from the muscle such as creatine phosphokinase (cpk), lactic dehydrogenase (ldh) and glutamic-oxaloacetic transamynase (got) are elevated. these enzyme activities in the serum of hyperthyroidism, euthyroidism and hypothyrodism have been known to have a good inverse correlation with protein-bound iodine (pbi). therefore, as part of a study of the re ...	1980	7418928
normal levels of norepinephrine in short term hypothyroidism.	plasma epinephrine and norepinephrine levels were measured in four cases of short term hypothyroidism which developed after parturition. for comparison, six patients with idiopathic hypothyroidism were included in the study. hypothyroidism was confirmed by clinical evaluation and tests of thyroid function, viz. serum t3, t4, free t4, and tsh. in all patients with idiopathic hyperthyroidism, epinephrine levels were normal and norepinephrine levels were significantly elevated. in the four patients ...	1980	7419674
distribution of subcutaneous thyroxine, triiodothyronine, and albumin in man: comparison with intravenous administration using a kinetic model.	distributional kinetics of radioiodinated t4 (t4), t3 (t3), and albumin (risa), after simultaneous administration by the sc and iv routes of 125i- and 131i-labeled compounds, were measured in normal subjects. data were analyzed by fitting them, using the saam technique, to models with three compartments for the iv administered compounds and a fourth compartment for the site of the sc injection. the radiopharmaceuticals administered sc transfered by first order kinetics from the injection site to ...	1980	7419686
the effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury.	the effect of triiodothyronine (t3) or thyroxine (t4) on functional recovery after acute spinal cord compression injury in the rat was assessed. rats treated with t3 for 14 consecutive days after injury showed significantly improved recovery at 12 and 16 weeks, and rats treated with t4 for 4 days after injury showed significantly improved recovery at 12 weeks as compared with control animals. the possible modes of action of these two hormones on the injured spinal cord are briefly discussed.	1980	7420154
suppression of thyroid radioiodine uptake by various doses of stable iodide.	we studied the effect of various doses of sodium iodide on thyroid radioiodine uptake in euthyroid volunteers by giving single doses of 10, 30, 50, and 100 mg and then daily doses of 10, 15, 30, 50, or 100 mg for 12 days thereafter. all single doses above 10 mg suppressed 24-hour thyroid uptake of 123i to 0.7 to 1.5 per cent. continued daily administration of 15 mg of iodide or more resulted in values consistently below 2 per cent. a small but statistically significant fall in serum thyroxine (t ...	1980	7421914
[thyroxine (t4) turnover and transport in kidney diseases with mild and marked proteinuria].		1980	7422552
the effect on ultraviolet mutagenesis of genes 32, 41, 44, and 45 alleles of phage t4 in the presence of wild-type or antimutator dna polymerase.		1980	7423852
studies on the deiodination of 3,3',5'-t3 (reverse t3) to 3,3'-t2 (diiodothyronine) in rat liver.	properties of the deiodination reaction of rt3 to 3,3' t2 in rat liver homogenate are reported and compared with t4 to t3 conversion under similar conditions. ph optimum and sh-group dependency of these two reactions are quite different, though both are concerned with 5' deiodination. the most potent activator of the reaction rt3 to t2' is dithiothreitol; the enzyme activity increases almost linearly even at very high concentration of this compound (the same is true for mercaptoethanol). glutath ...	1980	7424338
iodine induced thyrotoxicosis in apparently normal thyroid glands.	two male patients aged 36 and 52 years with thyrotoxicosis revealed a serum t3 of 2.8 and 6.5 nmol/l and a serum t4 of 166 and 238 nmol/l, respectively. both had been exposed to iodine (2-10 mg daily) for 2-12 months before thyrotoxicosis was diagnosed. urinary iodine excretion was high, 5000 and 10,000 nmol/24 h (624-1250 microgram). the uptake of 131i in the thyroid glands were low, none had goitre. their iodine intake was interrupted, urinary iodine excretion gradually decreased, and t3 and t ...	1980	7424476
what is the preferred initial method of treatment for squamous carcinoma of the tongue?	the medical records of 152 previously untreated patients with squamous carcinoma of the tongue were reviewed. radiation, surgery and the combination of both were analyzed with respect to the stage of disease treated, local and regional failure and ultimate salvage. the plan of treatment for a prospective patient is formulated based on the data. surgery appears to be the best initial treatment for cancers staged t2, t3 and t4. t1 lesions can be treated with either radiation or surgery, and select ...	1980	7425238
neostigmine, pyridostigmine, and edrophonium as antagonists of pancuronium.	this study was performed to compare the effects of three anticholinesterases on rates of recovery from pancuronium-induced neuromuscular blockade. pancuronium (3 mg/70 kg) was antagonized during nitrous oxide-oxygen-halothane anesthesia, in man, with neostigmine (2.5 or 5.0 mg/70 kg), pyridostigmine (10 or 20 mg/70 kg), or edrophonium (50 or 100 mg/70 kg). reversal was attempted at 10 per cent spontaneous recovery of muscle twitch, which was measured by use of train-of-four stimulation. followin ...	1980	7425377
assessment of serial cea determinations in urine of patients with bladder carcinoma.	carcinoembryonic antigen (cea) levels in urine and serum from 294 patients with bladder cancer in varying stages have been clinically evaluated. all urine samples were obtained from patients with intact renal function and without bacterial infection in the bladder. the samples were collected before, during, and at follow-up examination after radiotherapy. they were perchloric acid extracted before being assayed in a double-antibody radioimmunoassay. the geometric mean of urine cea levels for pat ...	1980	7427883
[aberrant form of t4 phage reorganization].		1980	7428609
photoperiodic control of thyroid function and wool and horn growth in rams and the effect of cranial sympathectomy.	eight adult soay rams (four control and four superior cervical ganglionectomized) were housed in an artificial lighting regimen of alternating 16-week periods of long days [16 h of light, 8 h of darkness (16 l:8d)] and short days (8l:16d) for nearly 3 yr, and the long term variations in growth of the wool and horns were recorded along with measurements of the plasma concentration of t4, t3, and testosterone. in the control rams all of the parameters varied in relation to the imposed lighting reg ...	1980	7428681
changes in hepatic iodothyronine metabolism during ontogeny of the chick embryo.	as a model of the changes in peripheral iodothyronine metabolism that occur during ontogeny, we have studied the metabolism of 125i-labeled t4 and several of its partially deiodinated derivatives by the liver of the chick embryo. homogenates of livers obtained from chicks varying in embryonic age from 8 days to the time of hatching (20-21 days) were incubated with various iodothyronines, all labeled with 125i in their outer or phenolic ring. rates and products of the reactions were analyzed by p ...	1980	7428690
interrelationship between thyroid and gonadal function in female japanese quail kept under short and long photoperiods.	the concentrations of progesterone, testosterone, oestrone, oestradiol, thyroxine (t4) and tri-iodothyronine (t3) in the plasma of 8-week-old female japanese quail exposed to short (6 h light: 18 h darkness; 6l:18d) and long (18l:6d) photoperiods were determined by radioimmunoassay after ovariectomy, thyroidectomy and treatment with t4. in birds exposed to short days treatment with t4 slightly increased both the concentrations of progesterone, oestrone and oestradiol in plasma and the weight of ...	1980	7430916
[morphological aspects of the carcinoma of the hypopharynx (author's transl)].	on an average 35%, of the carcinomas of the pharynx are localized in the hypopharynx. 44 carcinomas of the hypopharynx were analyzed which were observed 1970-1979 in the institute of pathology of the university of hamburg. the age peak lays in the 7th decade of age. 84% of the patients were male. 68% of the cases were localized in the sinus piriformis, 21% in the posterior wall and 11% in the post-cricoid area. the stage t4 of the tnm classification existed in 87% of the cases, a formation of he ...	1980	7464354
reciprocal changes in serum concentrations of triiodothyronine and reverse triiodothyronine between summer and winter in normal adult men.	serum concentrations of thyroxine (t4), 3, 5, 3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3, rt3), thyronine-binding globulin (tbg), thyroid stimulating hormone (tsh) and cortisol in summer and in winter were compared in carefully selected normal adult men (aged 30-49 yr); 107 people from sapporo (59 in summer and 49 in winter) and 15 hospital workers. a modest but significantly higher serum t3 concentration was recorded in winter than in summer, while t4, tsh, tbg and cortisol ...	1980	7460857
lack of effect of acetaminophen on serum t4, t3, reverse t3, 3,3'-diiodothyronine and 3',5'-diiodothyronine in man.		1980	7461602
growth hormone, glucocorticoid and thyroxine response to duration, intensity and wavelength of light in prepubertal bulls.	effects of duration, intensity and wavelength of light on growth hormone (gh), glucocorticoids, thyrotropin (tsh) and thyroxine (t4) concentrations in serum were determined in prepubertal bulls maintained at 18 to 22 c and 60 tp 70% relative humidity. mean gh was 8.3 +/- .8, 9.5 +/- 2.2 and 13.8 +/- 2.2 ng/ml (p greater than .10) during 6 weeks of exposure to 8 hr of light: 16 hr of dark (8l:16d), 16l:8d and 20l:4d, respectively. however, concentrations of gh were more variable (p less than .01) ...	1980	7462118
permissive role of l-thyroxine in the induction of stomach pepsinogen by cortisol in neonatal rats.	subcutaneous injection of cortisol (10 micrograms/g body wt daily for 5 days) into normal neonatal rats increased the activity of stomach pepsinogen after day 5. l-thyroxine (t4; 0.2 microgram/g body wt daily for 5 days) alone did not affect the activity but it somewhat enhanced the effect of cortisol. even before day 5, when no effect of cortisol alone was observed, t4 plus cortisol increased pepsinogen activity. in adrenalectomized, thyroidectomized neonatal rats, injection of cortisol alone d ...	1980	7452127
contribution of unexpected serum thyroxine (t4) abnormality to detection of thyroid disease.	the screening serum thyroxine (t4) was compared to the history and physical examination as a means of detecting new cases of thyroid disease in a university hospital outpatient population. of 13 new cases of hyperthyroidism diagnosed during the study period, 10 were suspected on the basis of history and physical examination, and 3 as a result of an elevated screening t4. of 32 new cases of hypothyroidism, 23 were discovered on the basis of history and physical examination, and 9 as a result of a ...	1980	7452154
the diagnosis and treatment of canine hypothyroidism.	hypothyroidism in dogs should be diagnosed by integrating the history, clinical symptoms and thyroid hormone assay. affected dogs have a slow onset of decreased activity, cold intolerance, and skin changes of thickening and mild hyperpigmentation. the hair coat becomes dry and coarse, and alopecia develops in friction areas. the non-specific clinico-pathological changes of a mild anaemia and hypercholesterolaemia do not occur consistently. the easiest and best documented thyroid hormone assay is ...	1980	7452658
[role of radiotherapy in tumors (t3 and t4) of the penis].		1980	7455216
[age-related changes in peripheral thyroid parameters, it hypophyseal regulation and relation to fat metabolism].	in 50 women and 57 men aged 20 to 80 years serum levels of t3, t4 and rt3 as well as tsh levels before and after intravenous application of trh and serum triglycerid- and cholesterol-levels were determined. regressions and multiple regressions were calculated with broca-index, and age. serum-t3 are significantly lower in old age than in younger people. in men serum t4-levels remain unchanged in old age, in women a significant rise can be observed. with rising age tbk rises in men and falls in wo ...	1980	7456615
amenorrhea.	the evaluation of amenorrhea requires a careful history and physical examination and a systematic, stepwise approach. pregnancy must be excluded. one or more of the following will help establish the diagnosis: prolactin, t4, lateral skull x-ray or tomograms of the sella, fsh, lh, urinary 17-ketosteroids and 17-hydroxysteroids, bone age, buccal smear for barr bodies, karyotype and the presence of withdrawal bleeding after a course of progesterone alone or cyclic estrogen plus progesterone.	1980	7457308
[t3, t4 thyroid hormone values before and after death].		1980	7458837
[fundamental and clinical evaluation of t4 radioimmunoassay by solid phase method. phadebas t4 ria kit (s-8537) (author's transl)].		1980	7460316
[fundamental and clinical evaluation of immo phase t4 ria kit (author's transl)].		1980	7460360
the effect of propranolol withdrawal on thyroid hormones in normal and hyperthyroid subjects.	blood thyroid hormone levels were measured during, and for 6 days after, treatment with propranolol (160 mg/day, 4-8 weeks) in five hyperthyroid patients and six normal volunteers. in hyperthyroid patients triiodothyronine (t3) and free triiodothyronine index (ft3i) rose to peak levels 60 h after propranolol withdrawal without significant change in thyroxine (t4) or thyopac-3 test. in normal subjects no significant change in thyroid hormone levels was seen during propranolol treatment or withdra ...	1980	7438461
effect of 3,5,3'l-triiodothyronine administration on serum thyroid hormone levels in hypothyroid patients maintained on constant doses of thyroxine.	in order to investigate the effect of 3,5,3'l-triiodothyronine (t3) administration on thyroid hormone concentrations in serum, thyroxine (t4), t3, 3,3',5'l-triiodothyronine (reverse t3, rt3) and thyroid stimulating hormone (tsh) concentrations in serum were determined before and after t3 administration in 10 hypothyroid patients maintained on constant doses of t4. ten hypothyroid patients given 100 micrograms of t4 for approximately 3 months had almost normal t4 and t3 concentrations in serum. s ...	1980	7439119
[liver deiodinase activity in rats after high and low fat iodine deficient diets].	male wistar rats were restricted on iodine intake by feeding pure diets, without iodine addition. the high fat diet contained 50% fat (hfd), the low fat diet 3% fat (lfd). control animals received the same diets, but with iodine addition. after feeding the diets for 7 or 19 weeks liver deiodinase activity was estimated. the iodine deficient animals showed a diminished enzyme activity in both diet groups. but after feeding the diet without iodine addition for 7 weeks the deiodinase activity signi ...	1980	7439127
effects and plasma levels of propranolol and metoprolol in hyperthyroid patients.	the effects and plasma concentrations of different doses of propranolol and metoprolol were studied in 34 hyperthyroid patients. the initial daily doses were propranolol 160 mg or metoprolol 200 mg. if the resting heart rate remained above 75 beats per min after treatment for 4-7 days, the dose was increased and the patient re-examined after a further 4-7 days. propranolol (n = 17) caused a reduced heart rate, a decrease in serum 3,3',5-triiodothyronine (t3) and an increase in serum 3,3',5'-trii ...	1980	7439251
the metabolism of t4 and t3 in cultured chick-embryo heart cells.	thyroxine (t4) and tri-iodothyronine (t3) were metabolized in cultured chick-embryo heart cells via inner-ring de-iodination and o-sulfation. the products of t3 metabolism were 3,3't2, 3't1, and sulfated esters of t3 and 3,3't2. the major product of t4 degradation was 3,3',5'-t3 (rt3). ono t3 was produced from t4. propylthioracil inhibited the metabolism of t3. pretreatment of cultures with t3 or t4 enhanced the metabolism of both hormones; actinomycin d and cycloheximide inhibited the stimulato ...	1980	7439522
hypothalamo-adenohypophyseal-thyroid interrelationships in the chick embryo. iii. total t4 levels in the plasma of decapitated chick embryos with adenohypophyseal transplants.		1980	7439666
a reappraisal of the goitre-prevention assay: determination of the thyroid secretion rate in the japanese quail and the relative potencies of t3 and t4 in preventing goitrogenesis.		1980	7439671
study of the kinetics of the thyroid hormones and the peripheral conversion rate of thyroxine to triiodothyronine in acute renal insufficiency under experimental conditions.	we studied the kinetic behavior of triiodothyronine (t3) and thyroxine (t4) in two groups of 10 sheep. one was used as the control group (i) and the other consisted of sheep with acute renal failure (a.r.f.) induced by an iv. injection of mercuric dichloride. five sheep of each group were injected with 125it3 and the remaining five with 125it4, later taking periodical extractions throughout the first 96 hours. the radioactive contaminants in the plasma were eliminated by extracting the hormones ...	1980	7439877
serum coenzyme q10 levels in thyroid disorders.	the correlation between serum coq10 levels and serum thyroid hormones in thyroid disorders was investigated in the present studies. serum coq10 was measured by high speed liquid chromatography utilizing ultraviolet detector. in normal controls, serum coq10 level of the male was higher than that of the female. serum coq10 level in hyperthyroidism was significantly lower than that of euthyroid subjects. but in hypothyroidism, serum coq10 level did not show any significant difference from that of e ...	1980	7439878
intellectual, school and occupational performance in patients with idiopathic hypothalamo-pituitary hypothyroidism and primary hypothyroidism.	intelligence quotient (iq), school and professional performance were reviewed in 33 patients with idiopathic hypothalamo-pituitary hypothyroidism. diagnosis was based on low t4 values and clinical signs. all were treated with growth hormone (hgh). in some, hypothyroidism became manifest only after hgh therapy. birth history revealed breech delivery in 24 and perinatal asphyxia in 15 of them. thyroid treatment was started at a mean age of 9.8 (range 4-18 years). the mean iq was 103.4 +/- 16.7 (sd ...	1980	7440232
canine hypothyroidism: a retrospective study of 108 cases.	hypothyroidism, defined as a serum concentration of less than 70 ng of triiodothyronine (t3)/dl or less than 1.5 microgram of thyroxine (t4)/dl, or both, was diagnosed in 108 dogs by means of radioimmunoassay techniques. both t3 and t4 values were determined in 96 dogs. both values were low in approximately 50% (47/96) of the hypothyroid dogs; 25% (24/96) were t3 hypothyroid (low t3, normal t4), and 26% (25/96) were t4 hypothyroid (normal t3, low t4). the t3 values varied markedly between animal ...	1980	7440313
bovine prolactin, tsh, t and t concentrations as affected by tall fescue summer toxicosis and temperature.	serum concentrations of prolactin (prl), thyrotropin (tsh), thyroxine (t4) and triiodothyronine (t3) were compared between holstein calves fed a toxic fescue (g1-307) and holstein calves fed a less toxic fescue (g1-306) at one of three environmental temperatures (low, 10 to 13 c; medium, 21 to 23 c; high, 34 to 35 c). three calves were assigned to each treatment combination, and hormone concentrations were determined before (basal) and after thyrotropin-releasing hormone (trh) was injected at 15 ...	1980	7440434
tumor host relations. vi. is alpha-ketoglutarate a tumor marker? association with tumor extent in humans--correlation with tumor size in rats.	a 4-year survey is presented on the alpha-ketoglutarate (kg) values in whole blood of 200 patients with malignant neoplasms mainly of the gastrointestinal tract and the female breast. a group of patients with benign surgical diseases served as control. kg showed an association with the extent of the primary tumor classified according to the tnm-scheme. the percentages of single values above the 2s-range of the control were as follows: t2: 18%,t3: 41%, and t4: 64%. the mean value of kg had highly ...	1980	7440629
dopaminergic modulation of circadian thyrotropin rhythms and thyroid hormone levels in euthyroid subjects.	basal tsh levels are known to rise during the evening, but the mechanism by which this rise occurs is poorly understood. the rise in tsh in response to dopamine (da) receptor blockade with metoclopramide in the morning in normal subjects and hypothyroid patients has provided evidence for a tonic inhibitory role for da in the control of tsh secretion. we have tested the hypothesis in normal, euthyroid volunteers (14 females, aged 20--40 yr; 12 males, aged 22--45 yr) that the nocturnal elevation o ...	1980	7440694
iodothyronine kinetic studies in the newborn lamb.	metabolic clearance rates and production rates for thyroxine (t4), triiodothyronine (t3) and reverse t3 (rt3) were determined by pulse injection kinetic techniques in newborn sheep between 7 and 14 days of age. the mean metabolic clearance rate for t3 (39.6 +/- 4.5 l/m2 per day) was significantly greater than that for t4 (7.25 l/m2 per day, p < 0.001). the mean value for rt3 (27.5 +/- 2.8 l/m2 per day) also exceeded that for t4 (p < 0.001) but did not differ from that for t3. the mean production ...	1980	7440940