Publications

gene 20 product of bacteriophage t4 its purification and structure.		1981	7334518
[radioimmunoassay of free thyroxine by amerlex free t4 ria kit (author's transl)].		1981	7335892
[a fundamental and clinical evaluation of amerlex free t4 ria kit (author's transl)].		1981	7335913
[normocalcemic hyperparathormonemia and articular chondrocalcinosis. study of 69 patients compared to 57 controls].	the level of parathyroid hormone was measured by heterologue c terminal radio-immunological assay in 69 patients with clinical or radiological manifestations of the type seen in primary articular chondrocalcinosis. they were divided into three groups: p1 with undetermined clinical arthropathies; p2 with sub-chondral and arthosic arthropathies; p3 with radiologically definite chondrocalcinosis. they were compared with 57 control subjects broken up into four groups: t1 with chronic rheumatic arthr ...	1981	7336102
[serum concentration of total thyroxine (t4), j-125-labeled triiodothyronine binding index (t3cu) and free thyroxine index (ft4i) in newborn infants].		1981	7336723
validation of radioimmunoassay for triiodothyronine, thyroxine, and hydrocortisone (cortisol) in canine, feline, and equine sera.	radioimmunoassay kits were validated for triiodothyronine (t3), thyroxine (t4), and hydrocortisone (cortisol) in canine, feline, and equine sera. in each assay, serial dilutions of serum inhibited binding of radioiodinated hormone to the antibody in a manner parallel to inhibition by standard solutions. parallel inhibition curves indicated that the same substance of standard solutions and serum inhibited binding and that the assays were specific. further examination of specificity indicated that ...	1981	7337299
thyroid influence on the growth of hepatoma hw-165 in wistar rats.	the development of a fast-growing hepatoma (hw-165) in normal euthyroid wistar rats, was shown to be stimulated by daily injection of a dose of triiodo-l-thyronine (t3) as low as 1.5 microgram/100 g body weight. administered to thyroidectomized rats, t3 completely restored the frequency of tumor initiation and accelerated the growth of the hepatoma, which had been considerably slowed down in hypothyroid rats. contrary to other investigators, working on fast-growing morris hepatomas, we did not o ...	1981	7337800
dna sequence of the tail fibre genes 36 and 37 of bacteriophage t4.		1981	7338921
male fertility and thyroid hormones.	on the basis of the results in vitro, it seems that the testicle does not respond to the action of the thyroid hormones. the study of the relationship between the blood concentrations of these hormones and the reproductive function of the organ is being made by the authors as a means of verifying this in vivo. the total blood concentrations of t4, (triioothyronine), and the index of free thyroxine (it4l) were therefore evaluated both in normal and infertile subjects. the concentrations of t4 sho ...	1981	7340368
[modulation of t4 to t3 conversion. comparative aspects (author's transl)].	the peripheral conversion of t4 to t3 has been demonstrated in primitive vertebrates, larval lampreys (which do not have thyroid follicles but synthesize t3 and t4 in the endostyle) and in more evolved vertebrates. up to now the presence of rt3 has never been demonstrated in fish, its eventual role in amphibia remains to be established but seems important in chick embryo. the conversion of t4 to t3 is stimulated during amphibian metamorphosis and in salt water fish, concurrently with stimulation ...	1981	7340699
[interference in the conversion of t4 to t3 and rt3 by medications in man].	several drugs are known to interfere in thyroid hormone metabolism: 1) they can affect directly and specifically t4 to t3 conversion. this can be observed in vivo and in vitro. in vivo serum t3 concentrations will decrease and rt3 concentrations increase. amiodarone, other iodinated compounds (cholecystographic agents: ipodate and iopanoic acid), propylthiouracil and propranolol are known to act in this way. 2) other drugs which induce the hepatic capacity to catabolize drugs will also affect th ...	1981	7340700
[detection of t4 by tetrabead-125 kit (author's transl)].		1981	7341007
the effects of floor temperature, supplemental heat and drying at birth on neonatal swine.	the objective was to determine the effects of floor temperature (20 or 30 c), supplemental heat (heat lamp or light bulb) and drying at birth on piglet survival to day 5. rectal and infrared skin temperatures were taken on 326 piglets for the first 8 hr postpartum. blood samples were obtained at birth, day 2 and day 5 and analyzed for thyroxine (t4), triiodothyronine (t3) and cortisol by radioimmunoassay. weight of each pig was recorded at birth and on days 1, 2, and 5. survival rates were monit ...	1981	7341612
[fundamental and clinical evaluation of amerlex free t4 radioimmunoassay system (author's transl)].		1981	7341808
[an assessment of measuring serum free thyroxine with a ria kit utilizing prebound anti-t4 microcapsules (damon) (author's transl)].		1981	7341810
[thyrotropic and thyroid hormone (t3 and t4) content in horton' s headache patients].	in 18 men with horton's headaches the levels of the following hormones were determined in the serum: tsh, t3 and t4. the determinations were performed during disease relapse and before starting treatment. the control group included 18 blood donors. in the control group the mean tsh level was 3.97 +/- 0.88 microunits/ml, t4 level was 109.06 +/- 26.88 nmol/l, and t3 1.48 +/- 0.14 nmol/l. in the group of patients the mean values were: 2.58 +/- 2.09 microunits/ml, 97.62 +/- 21.81 nmol/l, 1.07 +/- 0. ...	1981	7342000
[determination of serum thyroxine t4 in normal subjects and pregnant women (author's transl)].		1981	7343208
[another type of interaction between blood levels of digitalis and anti-arrhythmic drugs: digoxin and amiodarone. experience with long-term therapy].	in clinical arrhythmology it is often necessary to associate digitalis and antiarrhythmic agents. this calls for study of possible interaction between the employed drugs. we found a statistically significant correlation between digitalis and amiodarone plasma level in patients on long term treatment with both drugs. a statistically significant linear correlation between plasma amiodarone level and digoxin (0.25 mg/day) or beta-methyldigoxin (0.20 mg/day) was documented in 33 patients. 23 patient ...	1981	7343376
[screening for neonatal hypothyroidism by estimation of t4 and tsh. experience of three years on 6.340 new-borns (author's transl)].	since june 1977 to june 1980 screening program for neonatal hypothyroidism was carried out in the area of vicence. 6.340 newborns were screening, in the fifth day of life, primarily by measuring t4 levels, later by measuring both t4 and tsh levels in the blood serum. three babies were proved to have neonatal hypothyroidism: two cases showed athyreotic hypothyroidism, and one case was due to familial thyroid dyshormonogenesis. the incidence of this condition in our area is much higher than 1:3.00 ...	1981	7343914
placental inner ring iodothyronine deiodination: a mechanism for decreased passage of t4 and t3 from mother to fetus.		1981	7344219
relationship of thyroid hormone levels to the severity of the narcotic withdrawal syndrome.	serum t3, t4 and thyroid stimulating hormone (tsh) were evaluated in 24 neonates of mothers taking methadone and compared with 16 normal controls using cord serum and serum taken on days 1, 2, 3, 4, 7, and 14. patients were divided into treated (rx; n = 14) and not treated (no rx; n = 10) groups based on withdrawal scores and correlated to thyroid hormone levels. t4 levels were greater in the rx group when compared to controls on days 2, 4 and 7 (p less than 0.01) and when compared to the no rx ...	1981	7344878
plasma levels of thyroxine and triiodothyronine in women with breast cancer.	24-hour mean plasma levels of t3 and t4 were compared in 29 rigorously selected breast cancer patients (all stages) and 27 healthy women, and 8 a.m. "spot" plasma t4 levels were compared in 43 consecutive unselected breast cancer patients (all stages), 22 women with other-than-breast cancer, 21 women with miscellaneous non-cancerous illnesses, and the same 27 healthy women. the 24-hour t3 levels were the same in the breast cancer patients and healthy controls, but the 24-hour t4 levels were sign ...	1981	7345972
modulation of t4 5'-monodeiodination in rat anterior pituitary and liver homogenates by thyroid states and fasting.	in order to clarify the role of the pituitary conversion of l-thyroxine (t4) to 3, 5, 3'-l-triiodothyronine (t3) in regulating thyrotropin (tsh) secretion, the effect of altered thyroid states and fasting on intrapituitary t3 generation was investigated by a paperchromatographic procedure using the anterior pituitary homogenates. hepatic t3 generation was also studied for comparison. the rate of pituitary and hepatic t3 generation in normal rats averaged 25.2 +/- 12.4 (mean +/- se) fmoles t3/mg ...	1981	7346264
changes in thyroid hormones following liver intoxication with carbon tetrachloride.	the metabolism of thyroid hormones was studied after carbon tetrachloride (ccl4) liver damage. thyroxine (t4) and triiodothyronine (t3) levels fell and reached a nadir in the first 24 hours after ccl4 administration. thyroxine binding globulins (tbg) and thyroid stimulating hormone (tsh) also decreased, reaching their lower values in the same period. blood and liver t4 turnover measured in ccl4 treated rats were faster than in control animals. therefore, at least three phenomena appear to be inv ...	1981	7185882
alterations of thyroid hormone indices in acute renal failure and in acute critical illness with and without acute renal failure.	the present study evaluated thyroid hormone indices of patients with acute renal failure without other systemic illnesses (n = 12), as compared to patients with critical illnesses in the presence (n = 16) and absence (n = 6) of acute renal failure. abnormalities in the group with acute renal failure alone included decreased serum levels of total t4 and t3, and elevated levels of free rt3. serum levels of free t4 by equilibrium dialysis and the enzyme immunoassay, t3 uptake ratios, tsh and total ...	1981	6817640
"euthyroidal' goiter and menstrual disorders.	we selected 5 patients, between 18 and 31 years of age, presenting menstrual irregularities and thyroidal goiter with no apparent functional change (normal, t4 and t3 tests). these patients underwent further examinations: tsh (basal and after trh stimulation), hprl (basal-circadian rhythm and after trh stimulation), fsh and lh (basal and after gn-rh stimulation), thyroidal scintiscan, search for antithyroid antibodies. basal and post-stimulation tsh was fundamental in 2 cases of subclinical hypo ...	1981	6809358
the effects of acute exercise on the level of blood serum tri-iodothyronine (t3), thyroxine (t4) and free thyroxine index (fti) in the aging male.		1981	6803066
thyroid function after thermal trauma.	the thyroid function was analyzed for 4-6 weeks in a prospective study of 12 thermally injured patients. the burn size range was 15-90%. serum concentrations of 3,5,3'-triidothyronine (t3) was suppressed and 3,3',5'-triidothyronine (rt3) was increased. the ratio t3/rt3 was subnormal on the third day after the trauma and normalized after 3 weeks. thyroxine and the free t4-index were within the normal range. the free t3-index were within the normal range. the tsh concentration was initially low bu ...	1981	6803354
suppression of the night increase in serum tsh during development of ketosis in diabetic patients.	the alterations in metabolic parameters, circulating iodothyronines and serum tsh were studied during a 21 h period of insulin withdrawal in 6 young patients with juvenile type diabetes mellitus. concomitant with the derangement of metabolic state a significant fall in serum t3 (in average 27%), serum free t3 (28%), and t4 (12%) was observed. serum free t4 remained unchanged. before and after the period of ketosis the normal diurnal pattern of high serum tsh at night and low levels during the da ...	1981	6801106
familial inappropriate tsh secretion: evidence suggesting a dissociated pituitary resistance to t3 and t4.	the study of pituitary thyroid relationships of a 40-year-old woman, suffering from recurrent goiter, is presented. the characteristics of this case were the following: i) constant hyperthyrotropinemia (range 8.2 to 29 micro u/ml) despite high thyroid hormone levels (mean total t4:13.4 microgram/dl; mean total t3:255 ng/dl) and clinical euthyroidism; ii) this tsh hypersecretion is not regulated by an excess of t4, while a suppressive effect is easily observed with t3. together with the clinical ...	1981	6801107
the relationship between metoclopramide and milk secretion in puerperium.	the authors administered metoclopramide to women in puerperium with poor lactation. an increased lactation and high serum prolactin levels were noted. the administration of this medicine did not provoke any variations in serum t3, t4 and tsh levels. thyroid screening of the treated mothers' babies resulted negative.	1981	6804132
[two cases of familial thyroxine-binding globulin (tbg) deficit identified by the screening of neonatal hypothyroidism (author's transl)].	thyroxine-binding globulin deficiency is a well-known condition transmitted as a x-linked dominant trait or as autosomal dominant trait. this condition is benign and hypothyroidism is never associated. values of t4 in the serum are abnormally low, tsh values are normal, rt3u values are high. tbg deficiency probably are much more diffuse than we believed in past. therefore it's possible to detect this deficit through screening programs for neonatal hypothyroidism. in this paper we describe two c ...	1981	6806781
a case of idiopathic hypothalamic hypothyroidism.	the availability of thyrotropin hormone (trh) has made it possible to determine whether tropic hormone deficiency is caused by pituitary or hypothalamic dysfunction. a case of hypothalamic hypothyroidism was described ina a 17 year old woman. this patient was admitted for the evaluation of hypothyroidism and secondary amenorrhea. her t3 and t4 were decreased, with an undetectable level of base line thyrotropin. the trh test revealed normal but delayed response of tsh. her base line prolactin and ...	1981	6803047
[behavior of triiodothyronine, tetraiodothyronine and thyrotropin during the trh test].	much confusion seems to exist on the timing and intensity of thyroid hormones (t4 and t3) response to trh. as a first approach to the problem, the authors performed trh test in 5 healthy women. tsh showed a significant increase immediately after the trh injection and kept high until the 90th minute. t3 decreased at first-still not significantly--then increased steadily and at 60 min it reached values significantly higher than the basal ones. some increase was seen for t4 too, but it did not show ...	1981	6802152
carcinoma of the tonsillar region: a comparison of radiation therapy with combined preoperative radiation and surgery.	ninety-six patients with cancer of the tonsillar region in all stages were studied to compare full-course radiation therapy with surgical salvage to planned radiation and surgery. full-course radiation therapy was effective in controlling t1 and t2 tumors without neck node involvement. combined therapy was much more effective in treating t3 tumors with neck node disease. patients with t4 tumors did poorly regardless of therapy.	1981	6801602
the effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man.	the effect of three different live microsomal enzyme inducing drugs on thyroid hormone metabolism was investigated. seven volunteers were randomly allocated in a crossover design to either antipyrine (1200 mg), phenobarbital (100 mg) or rifampicin (1200 mg) daily for 14 days. before and after each treatment the following parameters of enzyme induction were measured: antipyrine clearance, gamma-glutamyltranspeptidase, d-glucaric acid and 6-beta-hydroxycortisol urinary excretion. in addition, thyr ...	1981	6800809
atrial fibrillation and isolated suppression of the pituitary-thyroid axis: response to specific antithyroid therapy.	four patients are described with persistent atrial fibrillation associated with normal plasma total thyroxine (t4) and triiodothyronine (t3) but an absent plasma thyrotrophin (tsh) response to intravenous thyrotrophin releasing hormone (trh). initial cardioversion failed to establish sinus rhythm in three of the four patients. following specific antithyroid therapy to lower thyroid hormone levels sufficient to allow a normal tsh response to trh sinus rhythm was established in all four patients, ...	1981	6800967
dissociation of thyrotropin and prolactin responsiveness to thyrotropin releasing hormone stimulation in l-dopa treated parkinsonian patients.	the hprl, htsh and t3 response to thyrotropin releasing hormone (trh) stimulation (200 microgram i.v.) were studied in 8 parkinsonian patients under chronic l-dopa-carbidopa therapy. in 6 out of the 8 patients studied, treatment was stopped for a period of 2 weeks and the trh stimulation test was repeated under similar experimental conditions. in the l-dopa-carbidopa treated patients basal htsh levels and the htsh response to trh were significantly suppressed. by contrast, in the 6 patients 2 we ...	1981	6799381
[thyroid hormones and thyroid reserve in preclinical hypothyroidism].	preclinical hypothyroidism (i.e. basal thyroxine within the normal laboratory range, basal tsh normal or elevated and exaggerated tsh response to trh) is a biochemical constellation of uncertain clinical relevance. the oral trh test with simultaneous measurements of tsh and thyroid hormones before and 3 h after 40 mg trh provides information about both pituitary and thyroid reserve. in a group of female patients with preclinical hypothyroidism, basal thyroxine but not triiodothyronine was found ...	1981	6800029
small size t4 breast cancer. natural history and prognosis.	the clinical records of 66 patients with t4 (for skin infiltration or ulceration) breast cancer not larger than 5 cm treated with primary radiotherapy at the istituto nazionale tumori of milan from 1968 through 1977 were reviewed. the tumor measured no more than 3 cm in 19 patients and 3-5 cm in 47 patients. in the first group axillary involvement was lower (32% vs 55%) and mean age was older (68 years vs 58). thirty-four patients were irradiated with orthovoltage and 32 with cobalt, at full dos ...	1981	6792758
[effects of muscular exercise on non-glucoregulatory hormones (t3, rt3, t4, tsh, prolactin, fsh, lh) in type i diabetics (author's transl)].	in the present investigation the influence of muscular exercise on non-glucoregulatory hormones (t3, rt3, t4, tsh, prolactin) was analyzed in non-ketotic, juvenile-onset type diabetics (jd) in relation of their metabolic control. the plasma hormonal concentrations were measured in 8 well-controlled jd, 8 moderately controlled jd and in 8 healthy subjects, before, during and after a 30 min. bicycle ergometer test of moderate work intensity. the exercise-induced rise in t4, and rt3 was similar in ...	1981	6792851
alterations in thyroxine metabolism in crohn's disease.	to evaluate the possible alterations in thyroxine metabolism in patients with crohn's disease (c.d.), the serum concentrations of thyroxine (t4), triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), and thyroxine binding globulin (tbg) were determined in 23 patients with c.d. and in 25 healthy controls. while concentrations of t4 and rt3 in patients with c.d. were similar to those seen in healthy controls, serum t3 was lower in patients with c.d. (0.93 +/- 0.4 ng/ml) than in controls (1.20 +/- ...	1981	6783498
the tsh response to trh is exaggerated in primary testicular failure and normal in the male castrate.	basal tsh levels and the tsh response to trh have been evaluated in 26 males aged 20-48 years with primary testicular failure, and 6 males aged 58-69 years who had been orchidectomised for prostatic carcinoma. the patients with testicular failure were sequentially challenged at 30 min intervals with iv lrh (100 microgram), trh (200 microgram) and the dopaminergic antagonist, metoclopramide (10 mg). the castrates received a bolus of lrh and trh given together. the responses in the 2 patient group ...	1981	6784424
pathogenic mechanisms of neisseria gonorrhoeae: observations on damage to human fallopian tubes in organ culture by gonococci of colony type 1 or type 4.	the relative virulence of isogenic clones of colony type 1 (t1) (piliated) and colony type 4 (t4) (nonpiliated) gonococci was assessed in organ cultures of human fallopian tubes. the rate of damage to fallopian tube mucosa was determined by measurements of ciliary activity and was correlated with the sequential pathologic events observed by light and electron microscopy. during the first 24 hr of the infection, t1 gonococci attached to and damaged the mucosa more rapidly than did t4 gonococci. t ...	1981	6785363
the basal levels of serum prolactin (prl), luteinizine hormone (lh), follicle stimulating hormone (fsh), testosterone, thyroxine (t4), and cortisol in patients with pituitary mass: detection and evaluation.		1981	6785372
peripheral markers of thyroid status unaffected by endurance training in rats.	in order to more clearly define the relationship between endurance exercise training and thyroid activity we have measured t4 turnover in exercise-trained and sedentary rats under conditions of controlled food intake and body weight. rats were run on rodent treadmills at gradually increasing speeds and durations until at the end of 12 weeks they were running 2 h per day at 31 m/min. sedentary rats were either allowed to eat ad libitum or were food restricted so that they gained weight at the sam ...	1981	6785718
thyroxine-binding globulin deficiency in early childhood. postnatal changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins.	serial determinations of serum thyroxine (t4), triiodothyronine (t3), thyrotropin (tsh), thyroid hormone-binding globulin (tbg), prealbumin (tbpa) and albumin were performed in a euthyroid girl with tbg deficiency and in her mother for a period of 22 months after delivery. at 8 days old the child had a serum tbg concentration around 50% of normal level which remained essentially unchanged during infancy. total serum t4 and t3 concentrations were low, the free serum t4, free serum t3 and serum ts ...	1981	6785995
reduced active thyroid hormone levels after delivery.	the effect of delivery on the serum concentration of thyroid hormones was studied in 25 euthyroid women. after delivery serum free and total t3 and t4 fell transiently with a simultaneous increase in reverse t3 while serum tsh and thyroxine binding globulin (tbg) concentrations showed no significant variation. these data suggest that i) similar to what happens in other stressful situations, delivery influences peripheral t4 metabolism, and ii) an elevation of tbg in serum in the early puerperium ...	1981	6798093
significance of transient postnatal hypothyroxinemia in premature infants with and without respiratory distress syndrome.	the significance of relatively low thyroxine (t4) levels in preterm infants with and without respiratory distress syndrome (rds) was assessed by evaluating the free t4 level, the thyrotropin (tsh) response to thyrotropin releasing hormone (trh), and intellectual development in infants less than or equal to 35 weeks with cord blood t4 concentrations less than 6.5 microgram/100 ml. fifty-four (19 well, 28 with rds, and seven without rds and sick) of 215 premature infants (25%) and 27 of 8,831 term ...	1981	6798539
effect of the thyroid status and protein-calorie malnutrition on the rate of myofibrillar protein degradation in mature male rats.	the urinary excretion of n tau-methylhistidine (3-methylhistidine: 3-mehis), an index of the rate of myofibrillar protein catabolism, was determined in intact and thyroid ectomized mature male rats, receiving intraperitoneally either vehicle (0.9% nacl) or thyroxine (t4) replacement (2 microgram/100 g body weight/day) during 20 days. rats were fed either an adequate control of a low-protein low-energy diet. in addition, body weight changes and food intake were recorded throughout the experiment. ...	1981	6798648
rapid adaptation of pituitary responsiveness to trh in the post-surgical state. the role of free t3.	in eight clinically and biochemically euthyroid patients undergoing routine major non-thyroidal surgery preoperative and daily postoperative serum concentrations of total and free thyroid hormones were measured. thyrotrophin-releasing hormone (trh) tests were performed preoperatively and on the first 3 postoperative days. there was a significant fall in mean serum total and free triiodothyronine (t3) concentrations on the postoperative days and mean reverse t3 concentrations rose reciprocally. t ...	1981	6799234
effect of thyroid hormones on the in vivo protein synthesis in rats.	the studies were made in order to estimate the rate of tissue protein synthesis in euthyroid, hyperthyroid and hypothyroid rats (110 g body weight). hyperthyroidism was simulated by daily oral application of 4,44 micrograms thyroxine (t4) and 0,89 micrograms triiodothyronine (t3)/100 g body weight. hypothyroidism was induced by oral application of 17,8 mg of methylthiouracil (mtu) per day and 100 g body weight. in both cases the treatment lasted for 7 days. the concentration of both hormones in ...	1981	6786263
[changes in the intestines of obstetrical toad (alyte obstetrician) larvae during spontaneous metamorphosis or metamorphosis induced by thyroxine. morphometric study and changes in the protein/dna ratio].	during spontaneous metamorphosis of alytes obstetricans tadpoles (anuran amphibia), the gut undergoes important modifications. the gut weight/total weight and gut length/body length decrease by stage xviii. they reach maximum reductions of 83 and 90%, respectively, by stage xxiii. tail regression begins only by stage xx. the intestinal protein/dna ratio peaks to a maximum by stage xix, decreases greatly by stage xx then increases slightly by stage xxii. during thyroxine-induced metamorphosis, th ...	1981	6786774
inhibition of thyroxine binding to serum proteins by fenclofenac and related compounds.	the anti-inflammatory drug fenclofenac lowers the serum concentrations of thyroxine (t4) and triidothyronine (t3) in subjects taking a regular dose of 600 mg twice daily. in eight male volunteers the concentration of t4 in serum was reduced to almost a third of the pre-treatment value while the concentration of t3 fell by about a half. the interaction of fenclofenac, and related compounds, while the thyroid hormone binding proteins of serum was studied in vitro by equilibrium dialysis with measu ...	1981	6786805
the "abnormal" screening serum thyroxine (t4): analysis of physician response, outcome, cost and health effectiveness.		1981	6787061
thyroid status in elderly sick patients.	thyroid investigations were performed on 55 euthyroid patients hospitalized for chronic disease or recovering from acute illness. three age groups were considered. abnormalities were found only in patients over 75 years: 1) in the trh test the maximum increase in serum tsh (delta tshmax) was less marked and frequently delayed to 60 min, whereas the increase in t3 in 120 min (delta t3) was maintained; basal tsh was normal; 2) in 15 out of 28 cases, the pattern of circulating thyronines was abnorm ...	1981	6787108
effects of a single high oral dose of thyroxine on the pituitary-thyroid-axis.	ten euthyroid and 9 hypothyroid volunteers were orally administered 2 mg l-thyroxine (t4) to study the interaction between substitutive and suppressive effects of a single high t4 dose. after a significant rise the serum t4 concentration for 5 days in euthyroid and for 11 days in hypothyroid patients an inhibition of basal and of trh stimulated tsh release was observed. maximal inhibition of the tsh response in hypothyroid patients occurred 1 to 7 days after the individual t4 peak. this interval ...	1981	6787109
thyroid hormone abnormalities in patients with diabetes mellitus.	thyroid hormone abnormalities in serum were investigated in 47 patients with diabetes mellitus. although no significant differences in t4 were found between normal subjects and diabetics, a group of diabetics whose fasting blood sugar levels were over 250 mg/dl showed significantly higher reverse t3 (rt3) (p less than 0.01) and lower t3 levels (p less than 0.05) than healthy controls. a significant correlation was observed between rt3 and ffa levels in diabetics. moreover, patients in diabetic k ...	1981	6787111
augmentation of prolactin response to trh after cyproheptadine.	serum prl, tsh, t3 and t4 were estimated in the basal state and following iv bolus injection of 100 micrograms synthetic thyrotropin releasing hormone before and 7 days after cyproheptadine treatment in 5 healthy adult males. only the prl response to trh was augmented after cyproheptadine. this is perhaps related to the antidopaminergic effect of cyproheptadine.	1981	6787112
thyroid function and circulating antithyroid antibodies in myasthenia gravis.	evaluation of thyroid function in 104 patients with myasthenia gravis by t3, t4, tbg, and tsh radioimmunoassays and the trh-stimulation test in 47 patients disclosed thyrotoxicosis in 5.7%, preclinical hyperthyroidism probably due to autonomously functioning thyroid tissue in about 10% of patients stimulated with trh, hypothyroidism in 1.9%, and preclinical hypothyroidism in 3.4%. eighty-four percent were euthyroid. antithyroid antibody activity was detected by hemagglutination tests. twelve pat ...	1981	6787459
[studies on hypothalamic-pituitary thyroid regulation in hemodialysis patients (author's transl)].	during hemodialysis a continuous determination of free thyroid hormone and the basic tsh value was performed in 43 patients. a significant increase of free thyroxine and triodthyronine was found as well as a significant decrease of the tsh basal concentration in serum, which was already subnormal before hemodialysis. in 14 patients a tsh-trh-test was performed before, during and after hemodialysis. a considerable reduction of the pituitary sensitivity to trh administration during dialysis was fo ...	1981	6787568
hypothyroidism in severely iodine-deficient rats.	the thyroid status of severely iodine-deficient rats was assessed by measurement of the resting metabolic rate (rmr) and liver mitochondrial alpha-glycerophosphate dehydrogenase (alpha-gpd). rats maintained on the iodine-deficient diet for 2 or 3 months showed significantly reduced rmr and alpha-gpd, compared to rats on the same diet supplemented with ki in the drinking water. they also displayed markedly reduced serum t4 levels, slightly reduced serum t3 levels, and highly elevated serum tsh le ...	1981	6788539
hormone profile in lepromatous leprosy. a preliminary study.	in a preliminary study, 11 male patients with lepromatous leprosy were evaluated with regard to endocrinopathy and hormonal status. basal circulating hormone levels were estimated with a view to correlating the biochemical findings and clinical features. thyroid hormones t3 and t4, free thyroxine index (fti), tsh, and cortisol were within normal limits, indicating that further study of these hormones would not be worthwhile. the finding of elevated levels of prolactin as well as the gonadotrophi ...	1981	6788722
thyrotoxicosis and a thyrotropin-secreting pituitary tumor causing unilateral exophthalmos.	hyperthyroidism due to a tsh-secreting pituitary tumor has been noted by a number of investigators. we describe a unique case in which a 17-yr-old female presented with clinical hyperthyroidism, a goiter, and unilateral exophthalmos. serum t4, free t4, and t3 (ria) were consistently elevated along with elevated tsh levels (range, 10-100 microunits/ml). skull x-rays and computed tomography scan revealed a tumor invading the right orbit. other pituitary function studies were normal and lats was un ...	1981	6788793
the pituitary-thyroid axis after hemithyroidectomy in euthyroid man.	the pathogenesis of euthyroid goiter is assumed to be tsh dependent, but most studies have not demonstrated elevation of serum tsh. to elucidate the early events involved in thyroid growth, we studied thyroid function in eight euthyroid patients subjected to hemithyroidectomy for solitary cold nodules preoperatively and 2, 15, 60, and 90 days and 36 months, postoperatively. although within the euthyroid range, serum t4 decreased at 30 days and thereafter up to 90 days (p less than 0.01). basal s ...	1981	6788794
selective performance of the t3 uptake; a practical approach to thyroid function studies. concise communication.	of 5008 patients with normal serum thyroxine concentrations (t4 = 4.8-12.2 micrograms/dl) assayed by our laboratory during an 11-mo period, only 41 (0.82%) had an abnormal free thyroxine index (fti). narrowing the t4 normal range by 0.5 microgram/dl at both ends to create a discriminatory range of 5.3-11.7 microgram/dl reduced this number to 13 (0.26%). evaluation of the medical records for 11 of these 13 patients revealed his histories of estrogen and thyroid-hormone administration, individuall ...	1981	6788906
trh testing, t4-thyrotoxicosis and the aging thyroid gland.	secondary thyroid function tests were compared in 41 mildly thyrotoxic and 36 euthyroid patients with an elevated free thyroxine index (ft4i). a serum tsh measurement 20 minutes after intravenous trh (delta tsh) most reliably separates these two groups. a significant delta tsh response (greater than 0.5 microu/ml) is also helpful in excluding clinical thyrotoxicosis in patients with nodular goitre. the free t3 index was normal in one-third of mildly thyrotoxic patients and in all euthyroid patie ...	1981	6789262
syndrome of 'inappropriate secretion of thyroid-stimulating hormone' by partial target organ resistance to thyroid hormones.	a 74 year old woman was found to have elevated serum thyroid-stimulating hormone (tsh) levels and elevated serum thyroid hormone levels, with clinical euthyroidism. there was no evidence of a pituitary tumor. tsh levels increased substantially during methimazole therapy. administration of dexamethasone was followed by a prompt fall in serum tsh levels. triiodothyronine (t3) was administered over a period of 20 days in doses from 25 micrograms to as much as 100 micrograms daily causing a rise in ...	1981	6789594
plasma thyronine levels in carcinoma of the breast and colon.	plasma triiodothyronine (t3), reverse t3 (rt3), thyroxine (t4), total thyroid hormone-binding globulin (tbg) capacity, and serum albumin were assayed in patients with early and advanced breast and colonic cancer and in healthy women. plasma t3 levels were reduced in both breast cancer group, but were reduced only in colonic cancer patients with systemic metastases. plasma rt3 was normal in early cancer, but increased in nine of 38 (24%) with advanced breast cancer and four of 17 (24%) with metas ...	1981	6789787
alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism.	the present study concerns eighteen chronic alcoholics with minimal liver damage. a significant reduction in total serum t4 with an accompanying drop in circulating tbg was observed in these otherwise euthyroid patients. during alcohol withdrawal, we observed a rapid increase in t4 and tbg into the normal range. we suggest that the fall in the level of circulating thyroxine-binding globulin is related to a defect in its synthesis or secretion by the liver due to ethanol consumption. caution is r ...	1981	6790200
glutathione deficiency induced by cystine and/or methionine deprivation does not affect thyroid hormone deiodination in cultured rat hepatocytes and monkey hepatocarcinoma cells.	to elucidate the recently advanced hypothesis that glutathione [l-gamma-glutamyl-l-cysteinyl glycine (gsh)] regulates deiodinating enzyme activities, accounting for the decreased conversion of t4 to t3 in the liver of fetal and starved animals, we investigated thyroid hormone metabolism in gsh-depleted neoplastic and normal hepatocytes. in monkey hepatocarcinoma cells, intracellular total gsh decreased below 10% of the control value (approximately 25 micrograms/mg protein) when cells were grown ...	1981	6790265
clinical and biochemical effects of stanozolol therapy for hereditary angioedema.	stanozolol, an inexpensive anabolic steroid with a 30:1 anabolic:androgenic ratio, was administered to 12 male and 15 female patients with biochemically proven hereditary angioedema over a 2-yr period to obtain a systematic assessment of the relationship between drug dosage and clinical response, incidence of side effects, and amelioration of complement abnormalities. all 27 patients attained the minimal effective dose, ranging from 0.5 to 2 mg daily, which controlled the frequency and intensity ...	1981	6790595
stereospecific determination of d-thyroxin and l-thyroxin in serum.	a new method for separate determination of d-thyroxin and l-thyroxin in the serum was applied to study the response of serum levels of these isomers and of radioimmunologically determined total t3, total t4, free t4 and tsh upon administration of 2, 4 and 6 mg of a highly purified d-thyroxin preparation in six male patients with diffuse nontoxic goiter. d- and l-thyroxin are determined separately following extraction of the hormone from the serum and formation of diastereomeric dipeptides. the s ...	1981	6790815
assessment of thyroid function.	the thyroid hormones thyroxine (t4) and triiodothyronine (t3) can be measured directly in serum by radioimmunoassay. most serum t4 and t3 circulates bound to specific serum-binding proteins but the small unbound fraction, free t4, correlates best with hormonal activity. the free t4 concentration can be measured directly and also can be estimated from the t3-resin uptake as the free t4 index (ft4-i). in hypothyroidism, t4 and ft4-i are decreased and when the disorder results from thyroid gland fa ...	1981	6791080
[inappropriate thyrotropin secretion. part 2: non tumoral (author's transl)].	some patients are clinically euthyroid despite high thyroid hormones levels associated with detectable but not elevated serum tsh. these patients are considered as being resistant to thyroid hormones. the resistance may be severe or partial and in most cases seems to be autosomal dominant; it affects some tissues more than others, thus giving rise to a variety of clinical symptoms. in a few patients with high tsh levels extensive studies have failed to provide evidence of pituitary tumour of res ...	1981	6791128
[comparison of 100 micrograms trh intravenously and 40 mg trh orally in euthyroidism (author's transl)].	euthyroid in-patients were investigated with 100 micrograms trh given intravenously and with 40 mg trh given orally in order to compare the sensitivity of intravenous and oral trh-test. in all patients (age 15-91 years) maximal tsh-levels 180 min after 40 mg trh are significantly (p less than 0.01) higher than maximal tsh-levels 30 min after 100 micrograms trh. in patients under 50 years of age tsh-30 and tsh-180 are identical on average (6.42 +/- 0.29 microunits/ml vs. 6.53 +/- 0.54 microunits/ ...	1981	6791450
effect of di-n-propylacetic acid (valproic acid) on the tsh response to trh--a presumptive role for gamma aminobutyric acid.	the effect of di-n-propylacetic acid (valproic acid), an inhibitor of gamma aminobutyric acid (gaba) transaminase, was studied with reference to its effect on the serum concentration of thyroid hormones, baseline serum tsh concentration and trh stimulated tsh release, in seven normal controls and six patients with primary hypothyroidism. all volunteers took 250 mg of valproic acid administered orally, four times daily for 3 days. baseline serum t4 and tsh concentrations were unaffected by valpr ...	1981	6792461
effect of prolonged exercise on plasma prostaglandin levels.	the effects of a strenuous marathon run of 42.2 kilometers on the presence of prostaglandins in blood was investigated in 24 healthy males and females. testosterone, fsh, lh, epinephrine, norepinephrine, dopamine, t4 and t3 were also measured. with the exercise of the marathon run, a significant elevation of plasma pge2, pgf2 alpha and 6 keto pgf1 alpha was observed in the runners following the race. significant increases were also noted in blood catecholamine, dopamine and testosterone levels w ...	1981	6792640
familial thyroid hormone resistance.	eight patients with thyroid hormone resistance were found in four generations of a kindred containing 19 members. results of studies in this family are consistent with an autosomal dominant mode of inheritance for this disorder. the affected family members were clinically euthyroid but all had goiters and markedly increased serum thyroid hormone levels: thyroxine (t4) = 21.1 +/- 2.1 microgram/dl; triiodothyronine (t3) = 323 +/- 60 ng/dl; free t4 = 5.4 +/- 0.9 ng/dl; and free t3 = 1,134 +/- 356 p ...	1981	6792914
disordered breathing during sleep in hypothyroidism.	a 58-yr-old man with hypothyroidism and sleep apnea syndrome was studied to determine the cause of the nocturnal obstructive apnea and oxygen desaturation. control studies showed free thyroxine (t4) concentration of 0.7 ng/dl (normal, 0.8 to 2.3 ng/dl), and thyroid-stimulating hormone of 32 microiu/ml (normal, less than 12 microiu/ml). weight, pulmonary function, arterial blood gases, minute ventilation to carbon dioxide production ratio (ve/vco2), and the ventilatory response to exercise (delta ...	1981	6792957
thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses.	this study reports in vitro and in vivo parameters of t4 metabolism in patients with critical nonthyroidal illnesses who were selected because of serum total t4 values less than 3 micrograms/dl and normal tsh levels. despite the depressed total t4 concentrations, the normal serum free t4 values (7 of 9 patients), t4 production rates (8 of 9), and tsh responses to trh (8 of 8) provided evidence for normal free t4 availability to peripheral tissues. elevated rt3 values in 10 of 14 patients were co ...	1981	6793608
effect of iopanoic acid on the pituitary-thyroid axis: time sequence of changes in serum iodothyronines, thyrotropin, and prolactin concentrations and responses to thyroid hormones.	we have previously shown that some oral cholecystographic agents induce marked increase in basal and trh-stimulated tsh concentrations in normal subjects. to define the relationship between circulating iodothyronines and pituitary secretion after oral cholecystography, temporal changes in the responses of serum tsh and prl to a fixed dose of trh (500 micrograms iv) and in serum t4, t3, and rt3 concentrations were assessed before, immediately after, and then at weekly intervals after the three da ...	1981	6793610
human cord blood concentrations of thyrotropin, thyroglobulin, and iodothyronines after maternal administration of thyrotropin-releasing hormone.	trh or saline was administered to 214 term pregnant women at various time intervals (8-820 min) before delivery. cord blood (cb) was obtained, and plasma tsh, t4, t3, rt3, and thyroglobulin concentrations were measured by specific ria. cb tsh was significantly elevated within 20 min after trh administration and remained elevated for 180 min. cb t3 rose significantly by 60 min and remained elevated for 820 min. cb t4 was significantly increased from 120 to 820 min after trh administration. there ...	1981	6793611
peripheral resistance to thyroid hormone in an infant.	peripheral resistance to thyroid hormone, a syndrome characterized by elevated serum total and free thyroid hormone levels and abnormal tsh suppression without manifestations of hyperthyroidism, was studied in a clinically euthyroid 6-month-old infant. initial serum concentrations of t4, t3, and tsh were 22.1 micrograms/dl, 334 ng/dl, and 7.6 microunits/ml, respectively; infusion of synthetic trh increased the serum tsh to 47.4 microunits/ml, an exaggerated response. pituitary insensitivity to t ...	1981	6793616
endocrinologic studies in men exposed occupationally to carbon disulfide.	the effect of long-term occupational exposure to cs2 on various endocrinologic parameters was studied in 15 exposed men and 16 age-matched controls. duration of exposure varied between 10 and 36 yr. the cs2 concentrations in the viscose rayon plant have been below the finnish threshold limit value of 30 mg/m3 (10 ppm) under normal operating conditions for the past 10 yr. before this the exposure was considerably greater. of the various endocrinologic parameters, serum follicle stimulating hormon ...	1981	6793731
pituitary function in idiopathic haemochromatosis: hormonal study in 36 male patients.	thirty-six male patients with idiopathic haemochromatosis were subjected to measurements of basal plasma values of testosterone, lh and fsh and to an lrh test. nineteen were also subjected to basal plasma determinations of t3, t4, cortisol, tsh and prolactin and to a trh test. in 11 cases gh values were measured before, during and after an arginine infusion. seventeen patients were found to hae low levels of testosterone, lh and fsh, and no gonadotrophin responses to lrh. seventeen others had no ...	1981	6794282
[low serum thyroxin and thyroxin-binding globulin in neonatal respiratory distress (author's transl)].	measurements of thyroxin (t4), thyroxin-binding globulin (tbg) and tsh were carried out in 34 full-term newborns, 21 prematures and 11 neonates with respiratory distress (6 with hyaline membrane disease) at 5 days of age. in cases with neonatal respiratory distress and to a lesser extent in prematures, low t4 due to a decrease of tbg was found, tsh being identical in all groups. the positive correlation between tbg and transferrin suggests a disturbance in hepatic synthesis. the authors conclude ...	1981	6794534
increase in plasma thyrotropin-releasing hormone in normal human pregnancy.	maternal thyroid regulation in pregnancy was examined by measuring the concentrations of trh, t4, t3, free t4 (by ria), t4-binding globulin, tsh, prl, and hcg in the sera of 30 normal pregnant women, 10 puerperally lactating women, and 10 normal pregnant women, 10 puerperally lactating women, and 10 normal nonpregnant female controls. results showed that serum t4, t3, t4-binding globulin, prl, and hcg, but not free t4 (by ria), increased significantly during pregnancy. the plasma level of trh wa ...	1981	6795226
[pseudohypoparathyroidism with hypothyroidism (author's transl)].	this is a report about three children suffering from pseudo-hypoparathyroidism type i and moderate primary hypothyroidism. the thyroid dysfunction was characterised by slightly low plasma thyroxine and high basal tsh showing an increased response to trh. t3 and rt3 were within normal limits, the size of the thyroid glands and also bone age were normal. the plasma concentrations of t4 and tsh and the response of tsh to trh were no different during hypocalcemia from those obtained in normocalcemia ...	1981	6795572
influence of phenylalanine and lysine deficiencies on thyroid morphology in the chick.	a study was conducted to investigate the effects of dietary phenylalanine and lysine deficiencies on thyroid morphology in chicks fed crystalline amino acid diets. both mean follicle diameter and epithelial cell height were significantly reduced in birds fed either of the deficient diets as compared with controls. these results agree with previous studies on serum t4 and t3 concentrations where the effects of an amino acid deficiency were general and not limited to precursors of thyroxine.	1981	6795617
abnormal hypothalamic-pituitary function in polyostotic fibrous dysplasia.	hypothalamic-pituitary dysfunction was found in two patients with polyostotic fibrous dysplasia and leontiasis ossea. both patients probably had mccune--albright syndrome with early sexual development, disfiguring craniofacial bone lesions, cutaneous hyperpigmentation and gigantism in childhood. endocrinological studies revealed measurable plasma growth hormone throughout a 24-h sampling period with preservation of sleep augmented rises. the mean 24-h values were 329 and 7 ng/ml, respectively. b ...	1981	6796294
the effect of fenclofenac on thyroid function.	the non-steroidal anti-inflammatory agent fenclofenac competitively inhibits the binding of thyroxine(t4) and triiodothyronine (t3) by thyroxine-binding globulin(tbg). eight male volunteers completed a 4-week study during which they took fenclofenac 600 mg twice daily. the concentration of fenclofenac in serum reached a plateau after 1 week of therapy after which the mean concentration(+/sem) of the drug in serum was 78.6 o.2 mg/1. during the steady state period on treatment there were reduction ...	1981	6796298
the influence of carbamazepine on thyroid hormones and thyroxine binding globulin in hypothyroid patients substituted with thyroxine.	carbamazepine (cbz) decreases the serum concentration of thyroid hormones. it is proposed that cbz increases the extra-thyroidal metabolism of thyroid hormones. in order to test this hypothesis cbz was given to nine hypothyroid patients substituted with thyroxine (t4). a significant decrease in serum concentrations of t4, calculated free t4 (ft4), triiodothyronine (t3), and calculated free t3(ft3) was found after 3 weeks of cbz medication. the serum concentrations of tsh and the t4:t3 ratios wer ...	1981	6796303
limitations of a new free thyroxine assay (amerlex free t4).	we have assessed a new method of free t4 measurement (amerlex) which uses a novel unidentified t4-labelled analogue, said to be unreactive with t4 binding proteins in serum, together with an antibody that binds both analogue and t4. free t4 is assessed by competition with analogue for antibody binding-sites. the test method has been compared with free t4 measured by equilibrium dialysis and with a technique using an immobilized t4 antibody. all methods gave the expected free t4 levels in normal, ...	1981	6796307
pattern of thyrotropin and thyroxine plasma concentrations during the 24-hour sleep-wake cycle in the male rhesus monkey.	the 24-h pattern of the plasma tsh concentration was investigated in five male rhesus monkeys prepared chronically with right atrial catheters and electroencephalogram (eeg) electrodes. the preparation allowed frequent blood sampling (every 15 min), tv monitoring, and eeg recording from the adjacent room for extended periods of time from undisturbed animals. in addition, nap deprivation, 5 h total sleep deprivation, and specific sleep stage deprivation experiments were performed in order to test ...	1981	6796388
tsh and prolactin secretions in hashimoto's thyroiditis following withdrawal of thyroid hormone therapy.	changes in the pituitary-thyroid axis in patients with hashimoto's thyroiditis following withdrawal of thyroid suppressive therapy were analyzed. the group of patients with thyroid adenoma served as control (group i). patients with hashimoto's thyroiditis were divided into 2 groups on the basis of serum tsh levels 8 weeks after discontinuing the exogenous thyroid hormone (group ii, less than 10 microunits/ml; group iii, more than 10 microunits/ml). during treatment with l-t4(200 micrograms/day) ...	1981	6796396
free thyroxine levels in critically ill patients. a comparison of currently available assays.	two indices of free thyroxine (t4) and four methods of free t4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. all of the methods of free t4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. since the ideal screening test should be both sensitive and specific, all tests for free t4 used in this study should ...	1981	6796703
free thyroxine, thyroxine/tbg ratio and other in vitro tests of thyroid function evaluated by discriminant analysis.	t4, t3, tsh, ft4 (corning method), tbg, t3u and a diversity of free thyroid hormone indices were determined in serum from 72 reference persons and 337 patients with either thyroid diseases, tbg abnormalities, non-thyroid illnesses, or medications known to affect the results of thyroid function tests. ninety-six per cent were 20 years or older. none of the laboratory parameters showed significant age or sex dependence, whereas systemic illness and medications frequently influenced test results. t ...	1981	6797036
serum thyroxine, triiodothyronine, reverse triiodothyronine, thyroid stimulating hormone, thyroxine binding globulin and thyroxine binding pre-albumin concentrations in healthy african adults.	a study of the serum concentrations of the thyroid hormones thyroxine (t4), triiodothyronine (t3) and reverse triiodothyronine (rt3), thyrotropin (tsh) and the thyroid hormone binding proteins (thyroxine binding globulin (tbg), and thyroxine binding pre-albumin (tbpa)) in non-hospitalized adult nigerian african subjects was conducted. the subjects were divided into three subgroups, male subjects, non-pregnant female subjects and pregnant female subjects to highlight peculiarities of each sub-gro ...	1981	6797113
the variations in thyroid function tests compatible with clinical euthyroidism after medical and surgical treatment for graves' disease.	eight widely used tests of thyroid function (clinical and biochemical) were performed simultaneously on 46 thyrotoxicosis patients who were clinically well at a standardised interval after medical or surgical treatment. the aim was to establish the range of thyroid function compatible with clinical normality. while clinical scoring systems gave broadly similar results between surgically and medically-treated patients, thyroid biochemistry showed major differences. thus while 87% of medically-tre ...	1981	6797344