Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| studies on the heterogeneity of the 5' ends of the protamine mrnas from rainbow trout testis. | the structures of the 5' termini of the protamine mrnas (pmrnas) have been investigated by inhibiting their translation in wheat-germ extracts in the presence of 7-methyl guanosine 5'-phosphate (m7-gmp), an analogue of 'cap' structure in mrnas. second, the cap structures on pmrnas were examined by labelling the rna at the 5' end with t4 polynucleotide kinase and [gamma-32p]atp before and after removal of these structures with tobacco acid pyrophosphatase and alkaline phosphatase. the results ind ... | 1981 | 7284575 |
| thyroid function after radiotherapy and laryngectomy for carcinoma of the larynx. | total levels of thyroxine (t4) and thyroid-stimulating hormone (tsh) were measured in 37 patients who had previously had carcinoma of the larynx treated by radiotherapy and total laryngectomy with thyroid lobectomy. ten percent of the patients had clinical features of hypothyroidism and 30% had total t4 levels below the lower limit of normal. a further 40% had results in the low normal range. forty-four percent of patients had raised tsh levels, 90% of these having low or low normal t4 levels. t ... | 1981 | 7287444 |
| a kinetic model of human thyroid hormones and their conversion products. | we have examined the in vivo distribution and metabolism of radiolabeled t4 and t3 in 14 normal subjects using a kinetic model. tracer amounts of [131i]t4 and [125i]t3 were injected simultaneously, and plasma samples were obtained for up to 7 days thereafter. separation of these samples by thin layer chromatography yielded kinetic curves for 131i- and 125i-labeled t4, t3, iodide, and iodoprotein, which were then used to develop a kinetic model. the model includes several features. 1) submodels w ... | 1981 | 7287869 |
| 3,3',5'-triiodothyronine (reverse t3) in human cerebrospinal fluid. | to examine the metabolic products of thyroid hormones in the central nervous system, total and free rt3 as well as t4 in human cerebrospinal fluid (csf) were determined in 41 patients. total t4, t3, and rt3 concentrations in csf were determined by ria, and free t4, t3, and rt3 fractions were analyzed by the magnesium precipitation method. the mean (+/- se) total t4 and t3 concentrations in csf were 166 +/- 24 and 2.6 +/- 1.5 ng/dl, respectively; the values were approximatey 2% of those in normal ... | 1981 | 7287874 |
| measurement of serum t4 concentration by high performance liquid chromatography. | although ria techniques for the measurement of serum t4 have been extremely useful, this methodology has several disadvantages, including the requirement for the use of radioisotopes, various levels of thyronine cross-reactivity, and the ability to measure only a single iodothyronine in one assay. we have developed a high performance liquid chromatography (hplc) method for quantitating serum t4 that utilizes the detection of dansyl-t4 compounds and obviates the problems described for ria techniq ... | 1981 | 7287878 |
| hepatic bioavailability of serum thyroid hormones in nonthyroidal illness. | serum was obtained from 11 patients with nonthyroidal illness (nti) and from 9 control subjects. patients with nti demonstrated decreased total t4 and t3 levels; increased rt3, t3 resin uptake, and percent free (dialyzable) t4 levels; and normal tsh and free t4 concentrations in vitro. in addition, the effects of control and patient sera on the first pass extraction of labeled t4 and t3 by rat liver was measured with a tissue sampling-single injection technique. the percent of total serum t4 and ... | 1981 | 7287879 |
| kinetic studies of thyroxine, 3,5,3'-triiodothyronine, 3,3,5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine in patients with liver cirrhosis. | turnover studies of t4, t3, rt3, 3',5'-diiodothyronine (3',5'-t2), 3,3'-diiodothyronine (3,3'-t2), and 3'-monoiodothyronine (3'-t1) were performed in 10 patients with alcoholic cirrhosis of the liver and 9 euthyroid, healthy controls using the single injection, noncompartmental approach. the kinetics of all 6 iodothyronines were studied in the same individuals. a newly developed, simple and reproducible gel separation technique, followed by antibody extraction, was used for the quantitation of t ... | 1981 | 7287881 |
| hyperthyroxinemia with bradycardia and normal thyrotropin secretion after chronic amiodarone administration. | pituitary-thyroid function was tested in 15 euthyroid patients before, during, and after long term oral treatment with amiodarone (2-n-butyl-3,4'-diethylaminoethoxy-3',5'-diiodobenzoylbenzofurane; 600-1200 mg daily), an iodine-containing potent antiarrhythmic drug. the drug caused increases in serum total t4, free t4, and rt3, with a concomitant decrease in t3. baseline serum tsh was significantly higher after 1 week of drug treatment and returned to normal levels after 12 weeks of treatment. al ... | 1981 | 7287882 |
| hormone-induced ovulation in ambystoma tigrinum: influence of prolactin and thyroxine. | treatment of hypophysectomized or intact neotenic tiger salamander larvae (ambystoma tigrinum) with ovine prolactin (prl) increased sensitivity of the ovary to the ovulation-inducing hormones, human chorionic gonadotropin and luteinizing hormone (lh). effects of pretreatment in vivo with prl or thyroxine (t4) on the responsiveness of ovarian fragments in vitro to ovulation-inducing agents, lh, or progesterone (prog) in the presence or absence of prl were observed. in november (prior to normal sp ... | 1981 | 7288386 |
| genetic and amber fragment maps of genes 46 and 47 of bacteriophage t4d. | we constructed genetic recombinational maps of genes 46 and 47 by using five amber mutants in gene 46, nine amber mutants in gene 47, and two-factor crosses. two different amber fragments in gene 46 and three different amber fragments in gene 47 were detected on polyacrylamide slab gels in the presence of sodium dodecyl sulfate. the genetic maps agreed with the amber fragment maps; taken together, the data oriented all of the sites in both genes with respect to each other. given the relative map ... | 1981 | 7288925 |
| [determination of serum "free t4" by gammacoat total/free t4 radioimmunoassay kits-principle of the assay and comparative studies with equilibrium dialysis and free t4 index]. | 1981 | 7289214 | |
| [screening for congenital hypothyroidism in austria (author's transl)]. | screening for hypothyroidism is part of the austrian newborn screening for inborn errors and centralized (ca. 85.000 births/year). it began 1976 in 2 provinces and covers the whole country since 7.6.1978. primary t4 and selective tsh on 3 mm discs is used. control frequency is 0.14%, the frequency of permanent primary hypothyroidism is 1:4724. hypothyroidism seems more frequent in western- then in eastern- austria (1:4227 v. 1:5422). hypothyroid babies are almost double as frequently born in sep ... | 1981 | 7289430 |
| serum thyroid hormone abnormalities in psychiatric disease. | psychiatric illness is a cause of "euthyroid sick syndrome" (ess), defined as abnormal concentrations of circulating iodothyronines in euthyroid subjects with nonthyroidal illness (nti). we describe a prospective study of 150 consecutive psychiatric admissions studied by endocrine and psychologic techniques. based on 150 admission blood samples, we found a 7% incidence of ess and with serial samples (74 patients) the incidence was 27%, demonstrating that ess can develop after hospital admission. ... | 1981 | 7289880 |
| [the importance of thyroid hormone determination in the course of acute and chronic liver diseases]. | the ria values of thyroid hormones in the course of acute and chronic liver disease were studied to see whether they were related to the severity of the picture in a series of 50 healthy subjects and 133 with various hepatopathies: 26 with acute viral hepatitis, 18 with alcoholic liver disease, 16 with alcoholic cirrhosis without ascites and 33 with ascites, 14 non-alcoholic cirrhosis without ascites and 24 with ascites. a reduction in t3 proportional to the seriousness of the clinical and labor ... | 1981 | 7290469 |
| influence of ambient temperature on calorigenic action of thyroid hormones in young mice. | in 5- and 7-day-old haicr mice the calorigenic action of thyroxine (t4) and triiodothyronine (t3) was investigated at different ambient temperatures. after treating animals with 5 microgram t4 or 1 microgram t3 per g body weight and day, their oxygen consumption was compared with that of litter mate controls at 23 degree, 27 degree, 31 degree and 35 degree c. the hormone action was highly dependent on ambient temperature, 1 microgram t3 being most effective. a thyroid hormone effect could never ... | 1981 | 7290909 |
| methodological aspects concerning radio-immunoassay of blood thyroxine applicable to population screening. | a research methodology concerning introduction of thyroxine radioimmunoassay applicable to screening programs is reported. the reagents necessary for t4 assay were prepared and tested and the technical parameters, the stages and technical characteristics of ria-t4 in the laboratory were established. the ria method for t4 was compared with the cpba method and with the commercially available kits, both on samples taken from experimental animals and on hypo-, hyper- and normo-thyroid subjects. the ... | 1981 | 7291943 |
| autoregulation of 3, 3',5'-triiodothyronine production by rat liver microsomes. | conversion of thyroxine (t4) to 3,3',5'-triiodothyronine (rt3) was studied in rat liver microsomes. addition of rt3 at a physiological concentration to the incubation medium inhibited the deiodination of thyroxine to rt3. with a concentration of rt3 greater than 37.6 nm no net rt3 production at ph 8.0 was observed. further increases in rt3 concentration resulted only in degradation of added rt3 and no net synthesis of rt3 from t4 could be detected. the inhibitory effect of rt3 upon its own produ ... | 1981 | 7293657 |
| iodine metabolism and the effect of tsh in thyroid glands of early bovine embryos. | the ontogeny of the thyrotrophin-thyroid axis during the first trimester was studied in 104 bovine embryonic thyroids taken from foetuses of crown-rump length 1.4 to 19.2 cm (25-120 days). the uptake of labelled iodine in vitro in the absence or presence of tsh was measured. the per cent incorporation of radioiodine into iodotyrosines and iodothyronines in the presence and absence of tsh was also studied. it was found that the foetal tissue displayed radioiodine uptake by 25 days of foetal life ... | 1981 | 7293668 |
| effect of goitrogen administration on the circadian rhythm of serum thyroid stimulating hormone in the rat. | adult male rats were fed a goitrogen, aminotriazole, for 74 days at a dose known to suppress thyroid function completely. at the end of this period, these animals along with matched controls were killed in groups of seven at 3 hourly intervals throughout a 24 hour period, and serum tsh, t3, t4 and albumin assayed. no significant circadian rhythms of t3, t4 or albumin were found in either, but a highly significant rhythm of tsh was demonstrated both in controls and goitrogen treated groups, with ... | 1981 | 7293669 |
| sequential observation of changes in thyroxine, triiodothyronine and reverse triiodothyronine during the postnatal adaptation of the pig. | principal serum iodothyronines, t4, t3 and rt3, have been simultaneously measured by a specific radioimmunoassay in piglets kept for sequential observation with the mother from 1 to 21 days of age. during several hours postnatally, a high concentration of the hormone was noted as a result of an enhanced secretory activity of the thyroid gland. later, a progressive decrease with a nadir at about day 3 was observed, followed by a second rise in the hormone level. changes in t3 and rt3 levels from ... | 1981 | 7295839 |
| hormonal status in the newborn lamb (cortisol, t3, t4). relationships to the birth weight and the length of gestation: effect of the litter size. | the experiments reported involve 18 romanov lambs born spontaneously between 135 and 145 days of gestation. their birth weights ranged between 1.22 and 3.55 kg. the neonatal changes in plasma cortisol, triiodothyronine and thyroxine levels were observed from birth to 30 days postpartum, and related to the length of gestation and the birth weight. positive correlations were found between: (1) plasma t3 (2, 4, 8 h and 11 days after birth), t4 levels (4 h after birth) and the birth weight; (2) plas ... | 1981 | 7295840 |
| a study of the effect of sodium/meglumine ioxaglate (hexabrix) on thyroid function. | the effect of thyroid function was investigated in 22 patients undergoing arteriography with a new low osmolality contrast medium--sodium and meglumine ioxaglate (hexabrix). plasma thyroxine (t4), thyroxine resin uptake (tru) and free thyroxine index (fti) were measured before and at varying intervals up to 56 days after the arteriogram. despite the large doses of hexabrix used (up to 89.6 g of iodine), these tests of thyroid function did not reveal any significant change from pre-angiographic l ... | 1981 | 7296204 |
| neurenteric cysts of the spinal cord mimicking multiple sclerosis. | a 54-year-old man died following a 20-year course of intermittent neurologic symptoms. he carried a diagnosis of multiple sclerosis, with most severe involvement thought to be in the spinal cord. at autopsy, two neurenteric (enterogenous) cysts were found to indent the anterior spinal cord -- at the t4 and t11 cord levels. partial diplomyelia was present in the lumbo-sacral cord. these findings represent a unique combination of congenital abnormalities. their embryogenesis and pathogenesis are d ... | 1981 | 7296425 |
| effect of aging on the morphology and function of the thyroid gland of the cream hamster. further evidence for two different mechanisms of hormone secretion. | the effect of aging on the morphology and function of the thyroid gland of the cream hamster was studied by light and electron microscopy coupled with autoradiography or histochemistry. morphologically, aging induces an accumulation of lysosomal dense bodies and a loss of the phagocytosis of colloid droplets after stimulation with tsh. iodine uptake and organification occur normally and thyroglobulin synthesis, estimated by autoradiography with 3h-leucine, is not different from that observed in ... | 1981 | 7296644 |
| inner ring monodeiodination of thyroxine and 3,5,3'-l-triiodothyronine in rat brain. | to elucidate the metabolism of thyroid hormone in the central nervous system (cns), 5-monodeiodinating activities were studied by incubating t4 or t3 with an aliquot of the p2 fraction of the rat brain in the presence of dithiothreitol and measuring the amounts of rt3 or 3,3'-l-diiodothyronine (3,3'-t2) produced by ria. the production of rt3 or 3,3'-t2 was dependent upon duration of the incubation, amount of tissue used, temperature, and ph (the optimal ph was 8.0). these findings show that thes ... | 1981 | 7297495 |
| cloning of mouse beta-casein gene sequences. | casein messenger rnas (mrnacsn) were purified from lactating mammary glands of balb/c mice and used as a starting material for cloning of casein gene sequences. double-stranded casein cdna (ds-cdnacsn) was prepared and blunt-end ligated to hindiii-specific dna linker molecules. after digestion with hindiii, the dsdnacsn was inserted into the hindiii site of plasmid pbr322, using t4 dna ligase. escherichia coli strain rh202 was transformed with the hybrid plasmids, and transformants were selected ... | 1981 | 7297856 |
| [bone density and thyroid gland function in adolescents in relation to fluoride content of drinking water]. | in 26 adolescents between 13--15 years of age living in a region with increased fluoride concentration in drinking water (3 ppm = 3 mg naf/l) bone density-measurements by an i-125 profile scanner as well as measurements of thyroid function by means of numerous in vitro tests (t3u, t4, ft4-index, ria-t3, rt3, htg, tsh, thyroglobulin and microsomal thyroid antibodies) have been done. comparing 19 adolescents of same age from a region with low fluoride concentration in the drinking water (0,1--0,2 ... | 1981 | 7297984 |
| immediate opposite effect of salicylate on thyroxine and 3,5,3'-triiodothyronine versus 3,3',5'-triiodothyronine level in plasma in rats. | in a total of 46 male rats polyethylene tubings were introduced into femoral artery and vein under pentobarbiturate anesthesia. then heparin (300 u kg-1) was injected at 60-90 min after pentobarbiturate and two control blood samples were subsequently taken. after that sodium salicylate (200 mg kg-1) was injected i.v. and blood samples were taken at 30-420 min later. an immediate decrease of the thyroxine (t4) level in plasma to about 20% of original level and that of 3,5,3'-triiodothyronine (t3) ... | 1981 | 7298011 |
| metabolic insufficiency as a limiting factor in the dietetic treatment of obesity. | previous observations that acute total fasting decreases serum t3 and increase rt3 has prompted the following study. 17 obese women were placed on a 1000 kcal/day weight-reducing diet, and body weight (bw), serum t4, rt3u, t3, rt3, tsh and the achilles tendon reflex (atr) were estimated before and after each month for 3 consecutive months of the diet. the results showed a consistent decrease in serum t3, and inconsistent increase in rt3, a consistent prolongation of the atr and a levelling-off o ... | 1981 | 7298016 |
| hypercholesterolemia in diabetics with clinically unrecognised primary thyroid failure. | forty-nine diabetics with primary thyroid failure, as indicated by an elevated tsh concentration (tsh 38.0 +/- 5.4 mu/l, t4 63.0 +/- 4.0 nmol/l), without overt clinical evidence of hypothyroidism, had a higher (p less than 0.025) mean plasma cholesterol concentration (6.8 +/- 0.2 nmol/l vs 6.0 +/- 0.2 nmol/l) than 49 euthyroid diabetics (tsh 3.16 +/- 0.2 mu/l, t4 99.1 +/- 2.81 nmol/l) of equivalent age, sex, weight, diabetic treatment and duration of diabetes. no significant difference in trigly ... | 1981 | 7298021 |
| proposed mechanism for increased thyroxine deiodination in cold-acclimated rats. | groups of male rats were administered isoproterenol (iso), thyroxine (t4), or both (iso + t4) daily for 20 days in an attempt to mimic the effect of cold acclimation on the rate of outer-ring deiodination of t4 to triiodothyronine (t3) by 2,000-g supernatants of homogenates of liver and kidney. the rates of hepatic and renal deiodination of t4 to t3 in an additional group of rats exposed to 4 +/- 1 degree c for 20 days were 53 and 71% higher, respectively, than control. administration of iso (10 ... | 1981 | 7298455 |
| a new method for measurement of the conversion ratio of thyroxine to triiodothyronine in euthyroid man. | a new method for the measurement of the conversion ratio (cr) of t4 to t3 in euthyroid man is described. in contrast to previously described studies, this investigation relied on sampling of urine rather than plasma after isotopic labeling of the study subject. the cr value determined in six euthyroid men was 0.482 +/- 0.014. thus, approximately half of the daily t4 production is converted to t3 as determined by this method. a major advantage of this technique is its reproducibility, as demonstr ... | 1981 | 7298801 |
| peripheral responses to thyroid hormone before and after l-thyroxine therapy in patients with subclinical hypothyroidism. | twenty patients with serum levels of t4 and t3 within the normal range but with elevated serum concentrations of tsh were evaluated before and after treatment with l-t4. this therapy increased serum t4 (5.5 +/- 1.1 to 8.8 +/- 1.8 microgram/dl) and t3 (116 +/- 20 to 137 +/- 28 ng/dl) levels. cardiac systolic time intervals (sti) were significantly (p less than 0.01) reduced by this therapy. the preejection period (123 +/- 18 to 114 +/- 14 msec; n = 12), the change in preejection period (+17 +/- 1 ... | 1981 | 7298802 |
| reaccumulation of thyroglobulin and colloid in rat and mouse thyroid follicles during intense thyrotropin stimulation. a clue to the pathogenesis of colloid goiters. | since marine's observations some 50 years ago, it has been generally accepted that colloid goiters invariably result from colloid repletion of originally hyperplastic goiters after cessation of the goitrogenic stimulus. however, clinical observations suggest that many goiters never go through a stage of hyperplasia, but are colloid-rich from the beginning. we have injected rats and mice with thyrotropin (tsh), three times a day for 4 d, while the animals were kept on an iodine-rich diet (hid). a ... | 1981 | 7298855 |
| spinal cord herniation into a congenital extradural arachnoid cyst causing brown-séquard syndrome. case report. | this is a report of a patient who developed sharp intercostal pain and brown-séquard syndrome. displacement of the spinal cord toward an extradural mass was noted at the t4-5 vertebral level on iophendylate myelography and metrizamide computerized tomography myelography. multiple meningeal diverticular lesions of congenital origin were also found. surgical correction of the spinal cord, which had herniated into a laterally located extradural arachnoid cyst and become incarcerated, resulted in a ... | 1981 | 7299475 |
| a survey of schoolchildren from a severe endemic goitre area in spain. | all the boys and girls between six and fourteen years old regularly attending school in three villages from an area in spain known ass las hurdes were studied with respect to thyroid size, body weight and height. casual urine samples were obtained for the determination of iodine and creatine concentrations. capillary blood was spotted on filter paper and used for the determination of thyroxine and thyrotropin by radioimmunoassay. the same survey was carried out in 354 school children from madrid ... | 1981 | 7302120 |
| the comparative value of serum thyroglobulin measurements and iodine 131 total body scans in the follow-up study of patients with treated differentiated thyroid cancer. | this study is an attempt to unify the evaluation of patients with well-differentiated thyroid cancer after ablative therapy. as such serum thyroglobulin determinations on and off thyroid hormone (t4) therapy and iodine 131 total body scans were examined in 53 patient studies. no metastases were found in patients whose thyroglobulin value was undetectable (less than 1 ng/ml). values during t4 therapy that were detectable, even as low as 4.2 ng/ml, were occasionally associated with metastases. aft ... | 1981 | 7304653 |
| hypertrophic and hyperplastic effects of thyroxine on the submandibular gland of the mouse. | the nature of the trophic response of the mouse submandibular gland to thyroxine (t4) was examined. adult female swiss-webster mice were given daily subcutaneous injections of t4 (1 microgram/gm body weight) for two or four days; two injections of tritiated thymidine (3h-tdr) were given 24 and 29 hours after the last injection of hormone, and the mice were killed one hour after the last injection of 3h-tdr. one gland was analyzed chemically for dna content and for incorporation of 3h-tdr, while ... | 1981 | 7305011 |
| existence of intermediates in the refolding of t4 lysozyme at ph 7.4. | 1981 | 7306096 | |
| lysozyme activity of bacteriophage t4 ghosts. | bacteriophage t4 ghosts were found to possess lysozyme (mucopeptide n-acetylmuramoylhydrolase, ec 3.2.1.17) activity. this enzyme is probably responsible for the lysis from without, observed at high multiplicity of infection, a process independent of the presence of the e gene product which is also a lysozyme. the ghost lysozyme and e lysozyme differed with respect to their requirements for maximal catalytic activity and to some extent in substrate specificity. the ghost lysozyme was released fr ... | 1981 | 7306554 |
| autoantibodies to thyroglobulin cross reacting with iodothyronines. | serum thyroxine was consistently unmeasurable by radioimmunoassay in an elderly patient with myxoedema after successful treatment with oral thyroxine. abnormal binding of thyroxine was suspected and shown to be due to the presence in serum of antibodies of the igg variety. the characteristics of these antibodies with respect to their binding of thyroxine (t4), triiodothyronine (t3), reverse triiodothyronine (rt3) and human thyroglobulin (tg) were systematically studied. three preparations of tg, ... | 1981 | 7307280 |
| effects of cimetidine on pituitary function: alterations in hormone secretion profiles. | cimetidine, an h2 receptor antagonist, was given for 6 weeks to six normal male volunteers to study the effects on pituitary, adrenal, thyroid, and testicular hormone secretion. patients were studied before (day 1) and after (day 42) cimetidine (300 mg four times daily) therapy, and four of the six were restudied after discontinuing cimetidine for 1 month (day 72). basal tsh concentrations and responses to trh administration as well as t3 ria and t4 resin uptakes did not change during or after c ... | 1981 | 7307288 |
| [studies on the measurement on serum thyroxine with immophase total t4 ria kit (author's transl)]. | 1981 | 7307303 | |
| [basic and clinical evaluation of the method of free thyroxine levels in serum with radioimmunoassay: gammacoat f-t4 ria kit (author's transl)]. | 1981 | 7307304 | |
| [regulation of long tail fibril assembly and attachment in bacteriophage t4]. | 1981 | 7307913 | |
| [atrioventricular block after carotid pressure in hypothyroidism: normalisation after substitution treatment (author's transl)]. | severe auto-immune hypothyroidism, probably after hyperthyroidism, was diagnosed in a 79-year-old woman with hypothyroidism (t3 and t4 immeasurably low) without the classical signs of myxoedema heart. on carotid sinus pressure transitory first degree av block occurred and, on one occasion, complete av block. this response disappeared after substitution treatment for four weeks with 50 microgram l-thyroxine. further examination half a year later, on a maintenance of 75 microgram thyroxine, also g ... | 1981 | 7307991 |
| a tsh secreting pituitary tumor accompanied by high stature: presentation of a case and review of the literature. | a 23-year-old man of high stature, with hypogonadism and bitemporal-upper-quadrant visual defects was found to have a pituitary tumor. he had a slightly enlarged struma, while he did not show any signs of hyperthyroidism. his serum tsh level (10.4 microunits/ml) was slightly elevated in spite of increased levels of serum thyroid hormone (t3 249 ng/dl, t4 12.0 microgram/dl). neither the elevated serum tsh levels nor thyroidal uptake of 123i were suppressed after 7 days of 75 microgram triiodothyr ... | 1981 | 7308156 |
| cushing's syndrome associated with corticogenic hypothyroidism: a case study. | described here is a 27-year-old female, who had centripetal obesity, broad reddish-purple striae on the lower abdomen and hypertension. serum cortisol levels, the results of a dexamethasone suppression test and an adrenal scintigram with 131i-19-iodocholesterol were all compatible with cushing's syndrome due to an adrenal adenoma that secretes cortisol autonomously. this was confirmed by gross and microscopic examination of the removed adrenal tumor. in addition, the patient had markedly diminis ... | 1981 | 7308157 |
| correlation of t4 to t3 converting activity with t3 concentration in rat tissues. | the correlation between t4 5'-deiodinase activity and thyroid hormone concentration in rat tissues was sought. studies with normal and thyroidectomized rats indicated a significant correlation of the hepatic t3 concentration with the enzyme activity in liver homogenate (r = 0.80, p less than 0.01) or in liver microsomes (r = 0.08, p less than 0.01). the correlation between the hepatic t4 concentration and activity of the enzyme was less significant (r = 0.55, p less than 0.05 for homogenate, and ... | 1981 | 7308161 |
| the specificity requirements of bacteriophage t4 lysozyme. involvement of n-acetamido groups. | bacillus cereus peptidoglycan with n-unsubstituted glucosamine residues was insensitive to treatment with bacteriophage t4 lysozyme. after n-acetylation with acetic anhydride, t4 lysozyme cleared solutions of the peptidoglycan and reducing sugars were liberated. the digestion products were mainly of high molecular weight, since the peptidoglycan is peptide cross-linked to a great extent. n-propylation did not convert the partially n-unsubstituted peptidoglycan to a sensitive form. it is conclude ... | 1981 | 7308203 |
| thyroxine an triiodothyronine kinetics and extrathyroidal peripheral conversion rate of thyroxine to triiodothyronine in healthy elderly humans. | the influence of age on the kinetics of thyroxine (t4) and triiodothyronine (t3), and on peripheral conversion of t4 to t3, has been studied, comparing a group of euthyroid, healthy, elderly individuals to a group of young individuals. a monocompartment model was adopted for the kinetics of t4, while a bicompartment model was used for t3. no significant difference (p greater than 0.05) could be found in any of the kinetic parameters of t4 between the elderly and young groups. however, the follow ... | 1981 | 7308972 |
| lateralized differences associated with semantically varied auditory material. | eegs were recorded from 13 subjects while they listened to four tape-recorded passages differing in semantic content. the distribution of alpha band power over the two hemispheres, measured at t3/t4, was found to show significant task-dependent shifts. more reality-oriented passages tended to be processed with greater left-hemisphere involvement, while "pleasurable" material showed significant right-hemisphere involvement. since the differences in laterality were not related to grammatical measu ... | 1981 | 7309405 |
| the distribution of the sympathetic preganglionic neurons projecting onto the stellate ganglion of the guinea pig. a horseradish peroxidase study. | after injection of horseradish peroxidase (hrp) into the stellate ganglion (sg) of the guinea pig, labelled cells were found in the c8-t11 spinal cord segments. the hrp-positive neurons were located in the nucleus intermedio-lateralis pars principalis and funicularis (ilp and ilf) and in the nucleus intercalatus proprius and pars paraependymalis (icp and icpe). the icp and icpe neurons represented approximately one-fourth of the total number of labelled cells. the ilp and ilf neurons were mainly ... | 1981 | 7310048 |
| external quality control for t3 and t4 assays in italy: outline of the scheme and results of the first semester experience. | 1981 | 7310523 | |
| mutations that detoxify an aberrant t4 membrane protein. | 1981 | 7310885 | |
| translational reinitiation in the riib cistron of bacteriophage t4. | 1981 | 7310886 | |
| loss of thyroid hormones into feces in children on regular hemodialysis. | in 20 children on hemodialysis in vitro tests of thyroid function were made. total t4, free t4, and total t3 were below the normal mean. the daily loss of t3 into feces was significantly higher in dialysis children than in healthy controls. the loss of t4 into feces was somewhat higher in dialysis children than in healthy controls. the amount of hormonal iodine loss into feces was calculated. it was significantly higher in children on hemodialysis than in controls. it is concluded that the loss ... | 1981 | 7312638 |
| spindle density in sleep of normal subjects. | we studied sleep spindle activity in ten normal young subjects, five males and five females. the subjects were recorded on magnetic tapes according to standard procedures, and the tapes were scored automatically by a system described previously. spindle activity was analyzed on the c4-t4 lead of electroencephalogram, using a bandpass filter and discrimination of the integrated output of the filter. results indicated that spindle density was the same in stages 2, 3, and 4, and was much lower in r ... | 1981 | 7313391 |
| the effect of deep hypothermia on the secretion of thyroid hormones and cortisol and oxygen consumption in guinea-pigs. | adult guinea-pigs were exposed to cold (-20 degrees c) to the point of deep hypothermia, and the heart rate (hr), rectal temperature (tr) oxygen consumption (v02), serum concentrations of proteins, thyroid hormones (by t3 and t4 radioimmunoassays) and cortisol (by fluorometry) were determined and compared with those obtained from sham-exposed animals (22 degrees c) vo2, and hr rose to a maximum in 1 h in the cold, but then declined in parallel to tr for 2-3 h. the cold-exposed animals became unc ... | 1981 | 7315422 |
| [thyroid disorders during sarcoidosis (author's transl)]. | a clinical, scintigraphic and hormonal study of the thyroid was performed in 50 patients with intrathoracic sarcoidosis. the patients were divided into two groups: t - : n = 32, no thyroid abnormality; t +, 18 cases, with thyroid disorders (9 moderate diffuse goitres, 2 thyroid nodules, 7 nodular goitres). all had normal t4, t3 and tsh levels, except one patient with graves's disease. scarce sarcoid granulomas were found in 3 out of 4 patients who underwent thyroidectomy. dissemination, activity ... | 1981 | 7316303 |
| systolic time intervals in hyperthyroidism. | pepi (pre-ejection period index), qs2i (total electromechanical systolic index), lveti (left ventricular ejection time index), and pep/lvet ratio were measured in 35 thyrotoxic patients. none of the patients had clinical evidence of heart disease nor received drugs which might have affected the systolic time intervals. the hyperthyroid subjects showed significant shortening of pepi and significant reduction of pep/lvet, which returned within normal limits when the patients became euthyroid durin ... | 1981 | 7316457 |
| [effect of hormonal bursectomy on the serum t4 level in turkey poults (meleagris gallopavo var. domesticus)?]. | 1981 | 7316945 | |
| thyroid function in relation to trimethylamine oxidation in immature domestic fowl fed on rapeseed meal. | 1. two groups of 12-week-old female chicks were selected for their ability to oxidise 14c-trimethylamine (tma) after being fed on a diet containing 100 g high-glucosinolate rapeseed meal (rsm)/kg for 14 d. a third group (control) was fed on a rapeseed-free diet. measurements of thyroid activity and hepatic tma activity were made after a further week on the diets. 2. after feeding rsm, hepatic tma oxidase oxidase was very low (p less than 0.001) in one group (sensitive) but was unaffected in the ... | 1981 | 7317811 |
| hyperthyroidism in gestational trophoblastic neoplasia. | the thyroid status of twenty-seven african patients with gestational trophoblastic neoplasia (gtn) was studied. fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). of these fifteen patients, nine were clinically thyrotoxic. the most serious complication of thyrotoxicosis was life-threatening acute pulmonary oedema with associated cardiac failure. it was found that when serum levels of the human chorionic gonadotrophin ... | 1981 | 7318191 |
| [determination of free thyroxine in serum by anti t4 microcapsules (author's transl)]. | 1981 | 7318199 | |
| [the basic evaluation of spac t4 ria kit for the measurement of serum t4 (author's transl)]. | 1981 | 7318201 | |
| [measurement of serum total t4 concentration by immo phase t4 ria kit (author's transl)]. | 1981 | 7318202 | |
| [t3, t4, tsh and circulating antithyroglobulin antibodies in myasthenia gravis]. | myasthenia gravis (mg) is a rare neuromuscular disease which is known to be associated with hyperthyroidism at high frequency (3-10%). these investigations, however, are basing on studies of the basal metabolic rate, protein bound iodine (pbi) and the thyroidal radioiodine uptake. in our study (104 mg patients, 104 control subjects) we wanted to evaluate thyroid function on the basis of t3, t4, tbg and tsh radioimmunoassays and in addition we looked for the presence of circulating antithyroglobu ... | 1981 | 7318778 |
| 3',5'-diiodothyronine release from perfused dog thyroids. | a new radioimmunoassay for 3',5'-diiodothyronine (3',5'-t2) is described. the detection limit was 1-2 pmol/l with a sample size of 200 microliters. cross-reaction with t4, t3, and rt3 was 0.005, 0.003, and 1.3% respectively. the intra- and interassay coefficients of variation were 5.1% and 9.2%. dilution curves of effluent from perfused thyroid lobes of thyroid hydrolysate were parallel to the standard curve. by addition of 3',5'-t2 or rt3 standards to thyroid effluent sampling tubes or to thyro ... | 1981 | 7319469 |
| the diminished cardiac performance in severe thyrotoxicosis. parabolic correlation of lvet/pep to the circulating levels of thyroid hormones. | fifteen patients with thyrotoxicosis, 8 patients with primary hypothyroidism and 15 normal subjects were studied to assess the correlation between systolic time intervals and serum levels of thyroid hormones. in hypothyroid patients, prolongation of pepc (corrected pre-ejection period), shortening of lvetc (corrected left ventricular ejection time) and low values of lvet/pep ratio and cardiac output were improved after restoration of thyroid function. in thyrotoxic patients, shortening of pepc, ... | 1981 | 7320433 |
| inhibition of peripheral deiodination of 3, 5, 3'-triiodothyronine: an adverse effect of propylthiouracil in the treatment of t3-thyrotoxicosis. | an inhibition of peripheral conversion of t4 to t3 is thought to be of benefit in the treatment of thyrotoxicosis. therefore, propylthiouracil (ptu) has been considered to be more effective in the therapy of hyperthyroidism than methimazole, since the former has the additional peripheral effect of decreasing the conversion of t4 to t3, from in vitro studies ptu is known, however, to inhibit the deiodination at the 5' as well as at the 5 position of the iodothyronine molecule. to study if ptu blo ... | 1981 | 7320437 |
| selective synapse formation during sprouting after partial denervation of the guinea-pig superior cervical ganglion. | 1. the synaptic connexions established by sprouting of intact preganglionic sympathetic axons were examined by intracellular recording in vitro and by observing the sympathetic end organ responses to ventral root stimulation in vivo. 2. the superior cervical ganglion of the guinea-pig was partially denervated (70-85%) by crushing the cervical sympathetic trunk at the level of the subclavian artery, leaving the ansa subclavia intact. the intact nerve carried some preganglionic axons arising from ... | 1981 | 7320928 |
| influence of diverse gene 43 dna polymerases on the incorporation and replication in vivo of 2-aminopurine at a x t base-pairs in bacteriophage t4. | 1981 | 7321044 | |
| partial replication of uv-irradiated t4 bacteriophage dna results in amplification of specific genetic areas. | upon infection of escherichia coli with bromodeoxyuridine-labeled t4 phage that had received 10 lethal hits of uv irradiation, a sizable amount of phage dna was synthesized (approximately 36 phage equivalent units of dna per infected bacterium), although very little multiplicity reactivation occurs. this progeny dna was isolated and analyzed. this dna was biased in its genetic representation, as shown by hybridization to cloned segments of the t4 genome immobilized on nitrocellulose filters. pre ... | 1981 | 7321092 |
| monocistronic and polycistronic bacteriophage t4 gene 23 messages. | we studied transcription of t4 late genes by in vitro translation of size-fractionated late rna and by hybridization of t4 late rna to plasmids containing identified t4 late genes. we identified mrna species that coded for the late proteins gp10, gp18, gp21, gp22, gp23, and gp24. functional mrna's that coded for the early proteins gp32 and ipiii were also detected after fractionation of late rna. as in preparations of early rna, gene 32 message activity was present in two species of rna, which h ... | 1981 | 7321102 |
| bacteriophage t4 alc gene product: general inhibitor of transcription from cytosine-containing dna. | the alc gene of bacteriophage t4 was originally defined on the basis of mutations which allow late protein synthesis directed by t4 dna containing cytosine rather than hydroxymethylcytosine. the question remained whether the normal alc gene product (gpalc) also blocks the transcription of early genes from cytosine-containing dna. complementation experiments were performed between hydroxymethylcytosine-containing phage which direct gpalc synthesis but carry mutations in a given gene(s) and cytosi ... | 1981 | 7321103 |
| semiconservative dna replication is initiated at a single site in recombination-deficient gene 32 mutants of bacteriophage t4. | we have investigated, by electron microscopy, replicative intermediate produced early after infection of escherichia coli with two phage t4 gene 32 mutants (ama453 and tsg26) which replicate their parental dna but are defective in secondary replications and in moderating the activities of recombination nucleases. under conditions completely restrictive for progeny production, both of these mutant produced replicative intermediates, each containing a single internal loop. both branches of these l ... | 1981 | 7321104 |
| [radioimmunoassay of free thyroxine with microencapsulated anti-t4 specific antibody (author's transl)]. | 1981 | 7321329 | |
| the effects of prolonged exercise on spinally injured subjects. | the effects of prolonged exercise on paraplegics have not been reported. seven male paraplegic subjects with spinal lesions from t4 - t12 - l1 underwent an incremental wheelchair treadmill test to exhaustion. heart rate (hr), vo2max, and vestpd were recorded and calculated. one week later, subjects exercised in their wheelchairs at approximately 50% (mean = 52 +/- 2%) of vo2max for 60 min on a motorized treadmill. approximately 10 ml venous blood was withdrawn both 10 min and immediately prior t ... | 1981 | 7321822 |
| in vivo thyroxine release in day-old cockerels in response to acute stimulation by mammalian and avian pituitary hormones. | thyroxine (t4) level in the blood of newly hatched cockerels were measured at different times after the injection of bovine thyrotropin. a linear response to increasing doses of mammalian thyrotropin was seen when a two-injection protocol was used with a fifteen-hour interval between injections. blood t4 levels peaked 5 hr after the second injection and declined thereafter. this response was shown to be highly specific for thyrotropin from both mammalian and avian sources; gonadotropins, prolact ... | 1981 | 7322997 |
| [fundamental study of amerlex t4 ria kit (author's transl)]. | 1981 | 7323319 | |
| partial denaturation mapping of phage t4 dna at low temperature. | the partial-denaturation map of t4 dna is obtained by using benzyldodecyldimethyl ammonium chloride in the presence of a high concentration of formamide. in this way suitable conditions for preparation of electron microscope specimens and partial denaturation within a temperature range low enough to minimize the endonucleolytic cleavage, are realized. it is found that, under our experimental conditions, the denaturation increase depends mainly on the appearance of new denaturation sites rather t ... | 1981 | 7324534 |
| influence of epidural analgesia on postoperative changes in various serum enzyme patterns and serum bilirubin. | postoperative changes in serum bilirubin, various serum enzymes (alanine-amino transferase alat), alkaline phosphatase (ap), lactate-dehydrogenase (ldh), and creatine-phosphokinase (cpk)), plasma glucose and cortisol were studied in 20 healthy, premenopausal women undergoing elective abdominal hysterectomy under either general anaesthesia with halothane or epidural analgesia (t4-s5). surgery under general anaesthesia was followed by increased levels of bilirubin, ldh, cpk, glucose and cortisol, ... | 1981 | 7324821 |
| abnormal brown adipose tissue in genetically obese mice (ob/ob): effect of thyroxine. | lean and genetically obese (ob/ob): mice were treated daily for 2 wk with thyroxine (t4), noradrenaline, or thyroxine plus noradrenaline. t4 treatment of obese mice increased the abnormally low binding of gdp to brown adipose tissue mitochondria and permitted a cold-induced increase to occur. it also brought about a return to a more normal ultrastructure of the mitochondria of the obese mice. t4 treatment did not alter the binding of gdp to brown adipose tissue mitochondria of lean mice. the bin ... | 1981 | 7325226 |
| [plasma t4: adaptation of a commercial radioimmunoassay for use in dogs]. | 1981 | 7325426 | |
| thyroxine and triiodothyronine levels in thyroid vein blood and in thyroid tissue of patients with autonomous adenomas. | thyroxine (t4) and triiodothyronine (t3) concentrations were measured in peripheral and thyroid vein blood and in nodular and extranodular thyroid tissue from twenty-four patients with autonomous thyroid nodules (aftn); fifteen of these patients showed clinical signs of hyperthyroidism and nine were euthyroid. thirteen patients with solitary non-functioning thyroid adenomas who were clinically euthyroid, served as controls; samples of thyroid vein blood and normal thyroid tissue being obtained f ... | 1981 | 7326848 |
| long-term evaluation of thyroidal response to partial calorie restriction in obesity. | twenty obese patients were treated as out-patients with a 3.35 mj (800 kcal) per day diet, and, by the double-blind method, ten of the patients were prescribed 40 micrograms of triiodothyronine (t3) daily and the other ten placebo. body weight and serum thyroxine (t4), t3 and reverse t3 (rt3) concentrations were measured before treatment, then monthly over 6 months. no significant difference in mean weight loss was found between the patients receiving t3 and those on placebo. serum t3 concentrat ... | 1981 | 7326852 |
| [measurement of free thyroxine in serum using "spac-t4" ria kit (author's transl)]. | 1981 | 7326860 | |
| [a potential role of polyamines in goiter formation (author's transl)]. | changes in polyamine contents and in the activity of polyamine biosynthetic enzymes were studied in the rat thyroid. both exogenous and endogenous tsh promptly stimulated the activity of thyroid ornithine decarboxylase (odc) and s-adenosyl-l-methionine decarboxylase. treatment of the animals with antithyroid drugs resulted in an increase in circulating tsh level, the activities of the enzymes and thyroidal contents of putrescine, spermidine and spermine. theophylline, which stimulated methylthio ... | 1981 | 7327291 |
| in vitro estimation of cell kinetic parameters in human urinary bladder cancers. | the dna synthetic time (t4) and the labeling index (li) or urinary bladder carcinomas from 10 patients were measured by using the 3h-thymidine labeling technique in vitro under hyperbaric oxygen, and the potential doubling time (tpot) was determined. the li and tpot were enormously variable depending on the histologic type, and ranged from 3.7 to 18.0% and from 48 to 136 hr, respectively. in contrast, ts values fell in a rather narrow range. on comparing these results with the histologic patter ... | 1981 | 7327379 |
| iodine, thyroxine (t4), triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), 3,3'-diiodothyronine (t2) in normal human thyroids. effect of excessive iodine exposure. | 20 normal glands obtained from euthyroid subjects at autopsy were analysed for total iodine (tl), pbl, l-thyroxine (t4), 3,3',5-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), 3,3'-diiodothyronine (t2) after pronase hydrolysis. the mean tl was 325.1+-47.2 micrograms/g wet tissue, giving a total iodine per gland of 10.01 mg. pretreatment of iodine containing x-ray drugs in 8 patients did not significantly affect these results with the exception of lipiodol. the mean t4, t3 and t2 values we ... | 1981 | 7327524 |
| thyroid hormone concentrations in dialysate during hemodialysis in children. | thyroxine (t4) concentration in dialysate in the course of hemodialysis was determined in 15 children. concentrations were measured by a modified radioimmunoassay. during hemodialysis there was a slight increase in t4 concentration. at the end of hemodialysis t4 concentration was about 50% higher than soon after the onset of hemodialysis. the loss of t4 into dialysate during hemodialysis was 19.2 microgram; the loss of t3 was less than 75 ng. the amount of the daily loss of thyroid hormones into ... | 1981 | 7329808 |
| bacteriophage t4 head assembly. in vivo characterisation of the morphopoietic core. | 1981 | 7330045 | |
| the quaternary structure of the t4 gene product 20 oligomer. | gene product 20 of phage t4, which occurs in the phage particle near the head-tail interface, has been purified under moderate denaturing conditions. upon renaturation the protein forms ring-like structures, sedimenting at 19 s. the rings measure 17 nm in diameter and 7 nm in height. they are characterized by a central hole of 3 nm and have 12-fold rotational symmetry. the data are consistent with a dodecameric structure with a molecular weight of 0.8 x 10(6) daltons. the oligomers are able to a ... | 1981 | 7330050 |
| contraction and dissociation of the bacteriophage t4 tail sheath induced by heat and urea. | 1981 | 7330053 | |
| [comparative radioisotope study of the thyroid in various species of agricultural animals]. | radioisotope functional investigations of the thyroid gland were carried out with weaned lambs and pigs. the 131i captation capacity of the thyroid gland was studied to characterize the inorganic phase of iodine exchange. the evaluation of the hormone producing function of the thyroid gland required the determination of the level of the protein-bound 131i (pb 131i), t3-binding capacity of the thyroxin-binding globulin (tbg) and the ratio of the t3-binding capacity of tbg and the free thyroxin (t ... | 1981 | 7331231 |
| iodothyronines and thyrotrophin in serum after jejunoileostomy with 3:1 or 1:3 jejunoileal ratio. | serum levels of thyroxine (t4), 3,3',5-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3) and thyrotrophin, and t3-uptake were measured in 13 morbidly obese patients preoperatively and during the first five months after jejunoileal bypass surgery, in which period the patients lost 20% in body weight. they were randomized to a ratio of 3:1 or 1:3 between the jejunal and ileal segment included in the bypass, but the results in the two groups did not differ significantly. t4 level showed a sligh ... | 1981 | 7331659 |
| [serum somatomedin activity in children after surgery for craniopharyngioma (authors transl)]. | serum somatomedin activity was measured in 43 sera from 22 children aged 5 to 15 years operated on for a craniopharyngioma. all had a complete growth hormone deficiency and none received growth hormone therapy. at the time of the study, hydrocortisone therapy was given 29 times and thyroid powder 33 times. in these conditions, a highly significant correlation was found (r = 0.652, p less than 0.001) between somatomedin activity and growth velocity during the past three months. a negative correla ... | 1981 | 7332440 |
| effects of phentolamine on serum concentrations of tsh and thyroid hormones in hemithyreoidectomized rats. | the effects of phentolamine on the concentrations of tsh and the thyroid hormones in hemithyreoidectomized (hemitxized) rats have been examined. phentolamine caused a decrease of tsh level in blood serum 30 min after the injection, suggesting an inhibiting effect of phentolamine on tsh secretion. thyroxine (t4) concentration decreased after 30 min. while triiodothyronine (t3) fell 60 min after the injection, as either a consequence of the earlier tsh fall or a result of a direct inhibiting effec ... | 1981 | 7333226 |
| effect of barbital on the pituitary-thyroid axis. | barbital (diethylbarbituric acid), administered via the drinking water (0.1% solution), elicited mild goitrogenic responses in rats (p less than 0.05), accompanied by a slight depression in serum t4 titers (p less than 0.02). the goitrogenic responses appeared to be the result of slight elevations in the serum tsh levels and in the case of neonate rats, whose mothers were fed barbital during pregnancy and lactation, the elevations of tsh in the circulation were pronounced (p less than 0.01). how ... | 1981 | 7334184 |