Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| hormonal regulation of epidermal growth factor and protease in the submandibular gland of the adult mouse. | the structure of the granular convoluted tubules of the mouse submandibular gland is influenced by androgens, adrenal steroids, and thyroid hormones. we wished to investigate the effects of variations in hormonal status on the quantitative and qualitative distribution of two secretory products of these tubules, epidermal growth factor (egf) and protease. the effects of the thyroid and adrenal glands on egf content and protease activity of the submandibular glands of adult female mice were studie ... | 1981 | 7021131 |
| thyroid hormone metabolism in primary cultured rat hepatocytes. effects of glucose, glucagon, and insulin. | primary cultured adult rat hepatocytes were used to study regulation of thyroid hormone deiodination. control studies showed that these cells survived for at leas 4 d, during which time they actively deiodinated both the phenolic (5'-) and non-phenolic (5-) rings of l-thyroxine (t4),3,5,3'-triiodo-l-thyronine, and 3,3',5'-triiodothyronine. increasing the substate concentration caused a decrease in fractional iodide release and a corresponding increase in conjugation with sulfate and glucuronide. ... | 1981 | 7021591 |
| changes in the promoter range of rna polymerase resulting from bacteriophage t4-induced modification of core enzyme. | primary transcripts made in vitro on bacteriophage t4 dna by rna polymerase isolated from normal or t4-infected escherichia coli were compared by gel electrophoresis. bacteriophage-modified rna polymerase fails to initiate transcription at certain promoters recognized by unmodified enzyme. in the t4trna gene region, only one of the two promoters is active with the modified rna polymerase. reconstitution of separated rna polymerase components demonstrates that this change in promoter site selecti ... | 1981 | 7022450 |
| enumeration of t cell subsets in atopic dermatitis using monoclonal antibodies. | peripheral blood lymphocytes from 22 patients with atopic dermatitis, 17 age-matched healthy controls, 10 patients with other skin diseases, and 14 patients with either asthma or allergic rhinitis were characterized by reactivity with monoclonal antibodies to the surface antigens of helper-inducer (t4) and suppressor-cytotoxic (t8) t cell subsets and to a common t cell antigen (t3). in contrast to healthy controls and controls with other skin diseases or respiratory allergic disease, patients wi ... | 1981 | 6980906 |
| identification and separation by bacterial adherence of human lymphocytes that suppress natural cytotoxicity. | human lymphocyte subpopulations (b1, b2t1, t2t3, and t4, our denomination) have been previously identified by bacterial adherence, and differences in functions (mitogen responses, specific cytotoxicity, and natural killing activity) have been associated with some of these subpopulations. the natural killing activity (nk) was located in the t4 lymphocyte subpopulation. here we investigated the possibility that lymphocytes capable of suppressing the nk activity of the t4 cells could be identified ... | 1981 | 6969743 |
| the t-cell deficiency in atopic disease and its relation to hyperproduction of ige. | recent studies have given ample evidence that atopy is associated with a t-cell deficiency. this deficiency appears to be primary and not merely a consequence of disease manifestations. several studies have indicated that the t-cell defect displays a certain selectivity, resulting in imbalance between helper and suppressor t-cell in atopics. suppressor cells, carrying fc igg marker (t gamma cells) or being inducible by concanavalin a, have been found to be deficient, and recent data suggest that ... | 1981 | 6979840 |
| prolactin, growth hormone, thyrotropin, 3,5,3'-triiodothyronine, and thyroxine responses to exercise after fat- and carbohydrate-enriched diet. | the effect of 4 days of intake of a fat-enriched (76%) diet (f1 and f2 experiments) or a carbohydrate-enriched (77%) diet (ch experiment) on circulating levels of glucose, insulin, gh, prl, and thyroid hormones during prolonged exercise was studied in seven healthy males. after each of the three diet periods, the subjects ran on a treadmill at 70% of individual maximal oxygen uptake. at exhaustion, a 10-min rest was allowed, after which the subjects were encouraged to run while glucose (f1 and c ... | 1981 | 7005258 |
| serum concentrations of the iodothyronines in elderly subjects: decreased triiodothyronine (t3) and free t3 index. | in four groups of subjects free of thyroid disease, the following determinations were made: serum concentrations of thyroxine (t4), triiodothyronine (t3), reverse t3(rt3) and diiodothyronine (t2), and calculated indices of free thyroxine (ft4) and free triiodothyronine (ft3). group a comprised healthy subjects aged 16-64; group b, 24 healthy elderly subjects aged 68-95; group c, 23 elderly patients with mild well-controlled chronic illnesses, aged 70-85; group d, 40 nursing home residents aged 6 ... | 1981 | 7005294 |
| decrease of blood glucose, liver glycogen, and insulin and changes in glucose tolerance in suckling rats treated neonatally with high l-thyroxine doses. | the neo-t4 syndrome was induced by sc administration of high doses (30 microgram) of l-t4 (t4) during 5 consecutive days in the early postnatal period. rats were injected starting on the 3rd or 6th day of life. blood glucose and insulin levels as well as liver glycogen levels were determined between the 5th and 20th days of life. this covers the critical period for brain development (the 7th to 12th day) during which most myelination takes place. blood glucose and insulin and liver glycogen star ... | 1981 | 7007022 |
| trna2gln su+2 mutants that increase amber suppression. | we selected mutants of lambda psu+2 which had an increased ability to suppress on escherichia coli trp b9601 amber mutation on translationally stringent rpsl594 streptomycin-resistant ribosomes. trna2gin su+2 molecules produced from eight independent mutants were purified, and their ribonucleic acid sequences were determined. two types of mutations were mapped to the trna2gin su+2(glnv) gene by this method. both altered the pseudouridine at position 37 of the trna anticodon loop. seven of the is ... | 1981 | 7007345 |
| in vitro thermal inactivation of a temperature-sensitive sigma subunit mutant (rpod800) of escherichia coli rna polymerase proceeds by aggregation. | a temperature-sensitive mutant sigma subunit (rpod800) purified from escherichia coli was inactivated in vitro by temperatures in excess of 37 degrees c whereas wild type sigma remained stable up to 49 degrees c. both temperature-sensitive and wild type sigma formed multimeric aggregates upon thermal inactivation which were visualized by electron microscopy as polymeric chains. conditions favoring sigma monomer (low sigma concentration and binding to core polymerase) protected temperature-sensit ... | 1981 | 7007376 |
| enzyme immunoassay for the prostate-specific acid phosphatase (e. c. 3.1.3.2). | the clinical application of enzyme immunoassay for the determination of the prostate-specific acid phosphatase is reported. 227 sera were investigated in the diagnosis as well as in tumour monitoring and a good correlation with the clinical stage was found. in prostatic carcinomas 5 of 13 with stage t1, 11 or 12 patients with stage t2, 16 of 16 patients with t3 and 19 of 19 patients with stage t4 disease had values above 1 ng/ml. in prostatic adenomas (n = 69) in prostatitis (n = 40) and in othe ... | 1981 | 7022994 |
| [serologic affinity and specificity of action of pseudotuberculosis and coli-dysentery phages]. | the study of serological properties, specificity and the range of action has revealed affinity between y. pseudotuberculosis phages (pst, 3m, kotlyarova, 2344, 2391), some coliphages (t2, t3, t4) and sh. dysenteriae phage (dd iv). the existence of serovar iii of y. pseudotuberculosis phages has been established; to this serovar phage pst belongs. newly isolated 2344 and 2391 belong to serovar i. the problem of the existence of y. pseudotuberculosis phages as an independent group is discussed. | 1981 | 7023155 |
| enhanced release of t3 and rt3 compared to t4 from thyroglobulin during autolysis of dog thyroid homogenate. | previous studies on the secretion of thyroxine (t4), 3,5,3'-triiodothyronine (t3), and 3,3',5'-triiodothyronine (rt3) from perfused dog thyroids have indicated that a differential rate of secretion of various iodothyronines may take place. the aim of the present study was to evaluate whether the proteolysis of thyroglobulin taking place during secretion could be involved in this phenomenon. homogenate from the same dog thyroid was incubated either at ph 3.6 for 18 h without added protease or wit ... | 1981 | 7023163 |
| the effect of a very-low-calorie diet with and without chronic exercise on thyroid and sex hormones, plasma proteins, oxygen uptake, insulin and c peptide concentrations in obese women. | in 18 obese women a very-low-calorie diet (vlcd) has been combined with exercise (three times a week = 1650 kcal/week; 6.9 mj) and compared with the effects of diet alone. the adherence and tolerance of the diet was quite good. oxygen uptake decreased significantly only in the exercising group. sex hormones binding globulin increased while prealbumin and retinol binding protein decreased in both groups. changes in t4, t3, rt3, tsh, tbg and insulin secretion appeared to be equal in both groups. n ... | 1981 | 7024157 |
| childhood thyromegaly: recent developments. | evaluation of a child with goiter includes historical review, physical examination, and measurement of serum concentrations of pbi, t4 and t3ru, tsh, and titers of antithyroglobulin and antithyroid microsomal antibodies. if there are no indications for more intensive evaluation such as history of cervical irradiation, a palpable abnormality of the thyroid gland or unusual laboratory findings (e.g., a significant pbi-thyroxine iodine discrepancy in the absence of a positive antithyroid antibody t ... | 1981 | 7024497 |
| mapping of transcription units in the bacteriophage t4 trna gene cluster. | 1981 | 7024554 | |
| mutagenic specificity of nitrosomethylurea in bacteriophage t4. | in contrast to alkylating agents such as ethyl methanesulphonate which can induce mutation after treatment of free phage particles, nitrosamides induce mutations only when phage are treated intracellularly during infection of the host. the basis of this intracellular dependence is not currently understood. in this study the mutational specificity of nitrosomethylurea (nmu) in bacteriophage t4 was investigated by measuring the reversion of well-characterized mutants in the rii genes. while no mut ... | 1981 | 7024791 |
| mapping of in vitro transcription units and identification of primary transcripts of the d region of bacteriophage t4. | the d region of bacteriophage t4 is comprised of six closely linked genes which are situated between 161 kb and 165 kb on the t4 chromosome. we studied the transcription of these genes in vitro by using dna templates derived from a series of deletion mutants in this region. the mixture of primary products made by escherichia coli rna polymerase were fractionated by gel electrophoresis into discrete rna species. the results obtained together with the known map positions of the deletions allowed t ... | 1981 | 7024905 |
| production of thyroxine (t4) and triiodothyronine (t3) in nontoxic thyroid tumors. an immunohistochemical study. | thyroid tissue specimens from 27 patients with thyroid tumors were examined for thyroxine (t4) and triiodothyronine (t3) by the peroxidase-labeled antibody method. the result revealed localization of t4 in 12 of the 14 follicular adenomas, in all the 8 papillary carcinomas and in 1 of the 3 follicular carcinomas studied, and of t3 in 13 of the 14 follicular adenomas, in all the 8 papillary carcinomas and in all the 3 follicular carcinomas. in the tumor tissue, the thyroid hormones were demonstra ... | 1981 | 7025437 |
| a three-year streptococcal survey among singapore school children. part i--carriership of streptococci. | a prospective three years' survey, conducted on a total of 491 children attending four schools in singapore showed that the throat carrier rates for beta-haemolytic and group a streptococci varied from 15-31 percent and 6.6-15.7 per cent respectively. malays had the highest streptococcal throat carrier rates followed by indians/pakistanis and the chinese. there was no significant difference in streptococcal throat carrier rates between the sexes. children from lowest family income of less than $ ... | 1981 | 7025738 |
| membrane-associated dnase activity controlled by genes 46 and 47 of bacteriophage t4d and elevated dnase activity associated with the t4 das mutation. | lethal, amber mutations in t4 genes 46 and 47 cause incomplete degradation of host dna, premature arrest of phage dna synthesis, accumulation of abnormal dna replication intermediates, and defective recombination. these phenotypes can be explained by the hypothesis that genes 46 and 47 control a dna exonuclease, but in vitro demonstration of such a nuclease has not yet been reported. membrane and supernatant fractions from 46- and 47- mutant-infected and 46+ 47+ control-infected cells were assay ... | 1981 | 7026800 |
| total blood thyroxine and tsh levels in the newborns of an endemic goiter area in romania. | a neonatal screening of two approximately equal groups (376 in all) from (a) bucharest (a non-endemic area) and (b) cimpulung (an endemic area) was undertaken. ria of t4 and tsh in dry whole blood spots was performed using blood collected 3--5 days after birth. the results show a significantly lower t4 valu in group (b) as against group (a), i.e. 105.5 +/- 3.61 nmol. l-1 as against 146.3 +/- 1.61 nmol. l-1, and a significantly increased tsh value, i.e. 19.1 +/- 0.76 microu. ml-1 as against 10.9 ... | 1981 | 7027428 |
| visualization of dna in various phages (t4, chi, t7, phi 29) by ethidium bromide epi-fluorescent microscopy. | 1981 | 7028505 | |
| circulating diiodotyrosine: studies of its serum concentration, source, and turnover using radioimmunoassay after immunoextraction. | this report describes the application of a sensitive, specific, and reproducible ria for diiodotyrosine (dit) in human serum and metabolic studies on the source and kinetics of circulating dit. interference by cross-reactivity of t4 and other analogs was completely eliminated by isolation of dit from serum with an efficient preparative immunoprecipitation technique. mean (+/- sd) serum dit levels were 161 +/- 133 pmol/liter (7.0 ng/100 ml) in 41 normal subjects, 64 +/- 30 pmol/liter in 46 pregna ... | 1981 | 7028774 |
| translational regulation: identification of the site on bacteriophage t4 riib mrna recognized by the rega gene function. | the bacteriophage t4 gene rega encodes a protein that diminishes the expression of many unlinked early t4 genes. previous work demonstrated that rega-mediated repression occurs after transcription. we report here on the identification of the target site on one rega-sensitive mrna, the message encoding the phage t4 riib protein. the target for rega-mediated action overlaps the translational initiation domain of the riib messenger. the rega protein may be a repressor that operates translationally ... | 1981 | 7029523 |
| fast responses of bacterial membranes to virus adsorption: a fluorescence study. | after collision with their host cells, virus particles may remain mobile on cell surfaces until they become attached at firm binding sites. we propose that a virion will arrive within a typical median time at such a site, generating a membrane signal such as an increased membrane fluorescence in cells labeled with the voltage-sensitive dyes 8-anilino-1-naphthalene-sulfonate (mg-salt) (ans), n-phenylnaphthylamine (npa), or 3,3'-dipentyl-2,2'-oxacarbocyanine (di-o-c5[3]). we found that the time sp ... | 1981 | 7029540 |
| nonrandom substitution of 2-aminopurine for adenine during deoxyribonucleic acid synthesis in vitro. | the incorporation of the deoxyribonucleotide of 2-aminopurine [(ap)] for deoxyadenylate into deoxyribonucleic acid (dna) in vitro has been examined by using five highly purified dna polymerases: calf thymus polymerase alpha, escherichia coli polymerase i, and the polymerases induced by t4 phage mutant l56 (mutator phenotype), wild-type t4 phage, and t4 phage mutant l141 (antimutator phenotype). on a template of gapped salmon sperm dna, the overall incorporation of (ap) relative to the incorporat ... | 1981 | 7030386 |
| analysis in vivo of translational mutants of the riib cistron of bacteriophage t4. | 1981 | 7031268 | |
| dna ligase is required for encapsidation of bacteriophage t4 dna. | 1981 | 7031271 | |
| control of promoter utilization by bacteriophage t4-induced modification of rna polymerase alpha subunit. | after infection of escherichia coli cells, bacteriophage t4 induces several changes in the host dna-dependent rna polymerase. a well-characterized chemical change is a two-step adp-ribosylation of the enzyme's alpha subunit (1). in order to investigate the effect of this change on rna polymerase transcriptional properties in an in vitro system, we have reconstituted the enzyme from separated individual subunits which were obtained from normal or t4-modified rna polymerases. it is demonstrated th ... | 1981 | 7031602 |
| fine mapping of secondary structures of fd phage dna in the region of the replication origin. | a synthetic heptaribonucleotide, gaccccc, which is complementary to a unique site on fd bacteriophage dna, primes dna synthesis of fd by t4 bacteriophage dna polymerase. the rate of the gaccccc-primed dna synthesis was not uniform as reflected by the appearance of discrete dna fragments as replication intermediates on an alkaline agarose gel. after 10 minutes of synthesis a significant fraction of the dna product ran as a single band with a length of about 1960 nucleotides. we have isolated this ... | 1981 | 7031605 |
| 32p-labeling test for dna damage. | covalent adducts formed by the reaction of dna with chemical carcinogens and mutagens may be detected by a 32p-labeling test. dna preparations exposed to chemicals known to bind covalently to dna [n-methyl-n-nitrosourea, dimethyl sulfate, formaldehyde, beta-propiolactone, propylene oxide, streptozotocin, nitrogen mustard, and 1,3-bis(2-chloroethyl)-1-nitrosourea] were digested to a mixture of deoxynucleoside 3'-monophosphates by incubation with micrococcal endonuclease (ec 3.1.31.1) and spleen e ... | 1981 | 7031643 |
| [determination of serum t4 content in turkeys by the "enzyme multiplied immunoassay" (emit)]. | 1981 | 7032499 | |
| t cell subsets and langerhans cells in lichen planus: in situ characterization using monoclonal antibodies. | skin biopsies from four patients with lichen planus were studied using monoclonal antibodies directed against t lymphocytes. anti-ti and anti-t3 antibodies, which react with all peripheral t cells, stained most cells in the dermal infiltrates. the majority of infiltrating cells also stained with anti-t4 and anti-t4b antibodies, which react with helper/inducer cells, whereas a minority of cells stained with anti-t8 antibody, which reacts with cytotoxic/suppressor cells. surface igm was not identi ... | 1981 | 7032570 |
| fasting plasma hormones and metabolites in feral and domestic newborn pigs. | newborn yorkshire and ossabaw (feral) pigs were examined under thermoneutral conditions to determine whether survival rate during fasting differs between these breeds and whether any blood-borne factors are associated with improved survival. newborn pigs were removed from the sow before suckling. body composition was determined on 10 newborn ossabaw and 12 newborn yorkshire pigs. another group of animals (eight ossabaw, 12 yorkshire) was fasted for 72 hr, with blood samples drawn at birth and 12 ... | 1981 | 7033195 |
| effect of continuous thyroxine administration on thyrotropin secretion in thyroidectomized rats. | we have studied the effect of t4 itself (i.e. without extrapituitary conversion to t3) on the feedback regulation of pituitary tsh secretion in thyroidectomized rats receiving continuous t4 or t3 replacement. continuous sc infusion of 1.0 or 2.0 microgram t4/100 g . day in 0.01 n naoh, 20% 1,2-propanediol vehicle failed to maintain the plasma t4 concentration in thyroidectomized rats for more than 48 h, despite the verification of t4 delivery. continuous sc infusion of 1.0 or 2.0 microgram t4/10 ... | 1981 | 7227298 |
| effects of total fasting in obese women. iv. response of serum triiodothyronine (t3) and reverse triiodothyronine (rt3) to administered t3. | serum levels of t4, t3, rt3, rt3u and tsh were estimated in 12 obese women in the course of a 14-day fasting. seven of these patients were treated with t3 in a daily dose of 60--80 micrograms. fasting led to a small increase of serum t4, while fasting combined with t3 administration was accompanied by a small decrease of serum t4. serum t3 decreased in the course of the first 2 days of fasting to 40--50% of initial values and remained at this low level up to the 15th day of fasting. in the t3 tr ... | 1981 | 7227325 |
| synthesis, characterization and properties of ppp(a2'p)napcp and related high-specific-activity 32p-labelled derivatives of ppp(a2'p)na. | t4 rna ligase (ec 6.5.1.3) has been used to link cytidine 3',5'-[5'-32p]bisphosphate or unlabelled cytidine 3',5'-bisphosphate (pcp) covalently to the 3'-oh of individual components of 5'-triphospho-oligo[(2'-5')adenylyl]adenosine [ppp(a2'p)na with n = 2 or 3] and adenylyl(2'-5')adenylyl(2'-5')adenosine [(a2'p)2a] to yield 5'-triphospho-oligo[(2'-5')adenylyl]adenylyl(3'-5')cytidine 3'-phosphate [ppp(a2'p)napcp with n = 2 or 3] and adenylyl(2'-5')adenylyl(2'-5')adenylyl(3'-5')cytidine 3'-phosphat ... | 1981 | 7227373 |
| free thyroxine and free thyroxine index in women taking oral contraceptives. | this study compares the accuracy of the free thyroxine index and free serum thyroxine radioassay in evaluating the metabolic status of 36 euthyroid women, 17 of whom were taking oral contraceptive drugs. results indicate that the free thyroxine index does not uniformly compensate for estrogen-induced elevations in total serum thyroxine concentrations and that the free serum thyroxine is the test of choice in assessing the functional thyroid status of women taking oral contraceptive drugs. | 1981 | 7214772 |
| thyroid status in chronic alcoholics. | serum thyroxine (t4), triiodothyronine (t3) and thyrotrophin (tsh) were measured by radioimmunoassay in 39 chronic alcoholics on admission. two patients had a reduced circulating serum t4 and eight showed a low serum t3 level but basal tsh was not raised in any of the 39 patients. interestingly, low t4 and t3 levels returned to normal after abstinence and high protein and vitamin supplemented diet for one week. it is clear from our observations that a normo- or hypo- rather than a hypermetabolic ... | 1981 | 7215157 |
| plasma t4 and t3 levels in ambystoma tigrinum at various stages of metamorphosis. | 1981 | 7227809 | |
| changes in thyroid hormones in obese women following jejuno-ileal bypass surgery. | the serum concentrations of thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3'5'-triiodothyronine (reverse t3) in 10 massively obese women were studied before and at intervals for one year after jejuno-ileal bypass operation. a significant rise in t3 (p less than 0.01) over the immediately preoperative value, a significant fall in rt3 (p less than 0.01) but no significant change in t4 was found during the post-recovery follow-up period. it is concluded that maintaining a relatively high t3 le ... | 1981 | 7228473 |
| hypercalcemia in hyperthyroidism. role of age and goiter type. | hyperthyroidism is often associated with hypercalcemia which is provoked by osteoclastic activity of the thyroid hormones. these data show that hypercalcemia develops with increasing age and in the presence of a special type of hyperthyroid goiter. total serum calcium, total protein, and albumin as well as different parameters of thyroid function, namely t3 ria1, t4 test, etr and trh test were determined in a group of 147 patients. the ionized calcium level was estimated from total calcium and a ... | 1981 | 7230726 |
| basepairing potential of the 3' terminus of 16s rna: dependence on the functional state of the 30s subunit and the presence of protein s21. | the deoxyoctanucleotide 5'd (aaggaggt) which is complementary to the 3' terminus of 16s rna has been used as a probe to measure the potential of this rrna region to engage in intermolecular basepairing. the site specific binding of the octanucleotide is shown by labeling 16s rna in situ at its 3' end with [32p]pcp and t4 rna ligase (ec 6.5.1.3.). the label can be released as pa[32p]pcp by the simultaneous action of rnase h (ec 3.1.4.34) and 5'd(aaggaggt). we show that (1) 30s subunits prepared a ... | 1981 | 7232220 |
| [metastatic ovarian tumors in rectal cancer patients]. | under investigation were 207 female patients with carcinoma of the rectum aged 17 to 68 subjected to bilateral ovariectomy in addition to radical operation. a control group (95 women) subjected only to radical operations for carcinoma of the rectum was also analyzed. it was found that the metastatic spreading of the rectum carcinoma into the ovaries took place in 8.2% of cases. the ovaries were established to be involved in patients with a considerable spread of the primary tumor (t3-t4) growing ... | 1981 | 7233717 |
| treatment of maternal hyperthyroidism with antithyroid agents and changes in thyrotrophin and thyroxine in the newborn. | eleven pregnant women with concomitant hyperthyroidism were treated with antithyroid drugs. at monthly intervals serum thyroxine (t4) and triiodothyronine (t3) were measured with radioimmunoassay, the sephadex uptake of radioactive triiodothyronine (t3u) determined the free t4 and t3 indices calculated (ft4i, ft3i). tsh-binding inhibiting immunoglobulins (tbii) were determined by the radiomembrane assay. serum tsh and t4 were measured at delivery from cord blood and/or from the newborn infants s ... | 1981 | 7234286 |
| the disappearance of l-thyroxine and triiodothyronine from plasma and red and white skeletal muscle after administration of one sc dose of l-thyroxine to hyperthyroid and euthyroid rats. | rats were made hyperthyroid by repeated sc injections of l-thyroxine (t4) in a two-week period. at several time-points after the last injection, the triiodothyronine (t3) and t4 concentrations in plasma and red and white skeletal muscle were determined by a radioimmunoassay. this was done to investigate the relationship between the change in thyroid-hormone concentration in plasma and muscle and to see whether this change was similar in both muscle types. the results show that: 1. information ab ... | 1981 | 7234290 |
| [early prediction of hypothyroidism after subtotal thyroidectomy (author's transl)]. | 30 patients were classified euthyroid (group a, n = 13) and hypothyroid (group b, n = 17) 4 years after subtotal thyroidectomy. a retrospective analysis of the hormonal status was then performed. in both groups (a and b) a significant decrease of serum t3 was found 3 days after surgery. 3 months later t3 levels had returned to normal. serum t4 showed no significant change, neither at day 3 nor 3 months after the operation. serum thyrotropin (tsh) also showed no significant change 3 days after su ... | 1981 | 7234310 |
| screening for congenital hypothyroidism. i. laboratory results of a pilot study based on dried blood samples collected for pku screening. | a pilot study was performed to establish optimal conditions for nation-wide screening for congenital hypothyroidism in sweden. the levels of t4 and tsh were determined by automated radioimmunoassay in the dried blood spots, routinely collected for pku screening on the fifth postnatal day, from all 19 792 infants born in the stockholm area during a 14-month period. to identify safe minimum recall criteria for routine use, infants were recalled if the tsh level was more than 30 mu/l of plasma or-- ... | 1981 | 7234397 |
| screening for congenital hypothyroidism. ii. clinical findings in infants with positive screening tests. | in a pilot screening programme for congenital hypothyroidism, pku filter paper blood samples from 20 000 infants born in stockholm were analysed for tsh and t4 to identify optimal conditions for routine nationwide screening. among 160 infants with positive screening tests, 7 infants (group i) had true-positive results, 6 had primary and one secondary hypothyroidism. the 153 infants with false-positive tests were divided into group ii:74 infants with an isolated increased tsh level; group iii: 71 ... | 1981 | 7234398 |
| optimized blood sampling protocols and sequential design of kinetic experiments. | design of optimal blood sampling protocols for kinetic experiments is discussed and evaluated, with the aid of several examples--including an endocrine system case study. the criterion of optimality is maximum accuracy of kinetic model parameter estimates. a simple example illustrates why a sequential experiment approach is required; optimal designs depend on the true model parameter values, knowledge of which is usually a primary objective of the experiment, as well as the structure of the mode ... | 1981 | 7235042 |
| elevations of thyroid-stimulating hormone during acute nonthyroidal illness. | to determine whether the incidence of unrecognized thyroid disorders is high enough to warrant screening, we studied a group of 95 elderly hospitalized women with the use of clinical examinations, along with thyroid function tests. we found that 13 (13.7%) of the 95 women had elevated serum thyroid-stimulating hormone (tsh) levels and mean serum thyroxine (t4) levels, and their free t4 indexes and triiodothyronine levels (measured by radioimmunoassay) were lower than the levels in the normal con ... | 1981 | 7235805 |
| factors altering thyroid hormone metabolism. | thyroxine, the major secretory product of the thyroid gland, is metabolized in the peripheral tissues by phenolic conjugation, deamination, decarboxylation, and a cascade of monodeiodinations. this brief review focuses on the deiodination reactions, which currently are under intensive investigation. one product, 3,5,3'-triiodothyronine (t3), is the major active form of the thyroid hormone, and about 80% of the t3 produced in the body is derived extrathyroidally. furthermore, a greater fraction o ... | 1981 | 7238448 |
| lack of distant relationship between lysozyme ch and hen egg white lysozyme: computer comparison studies. | a computer search, made for distant relationships between lysozyme ch, hen egg white lysozyme, and bacteriophage t4 lysozyme, revealed no unusual similarities in their amino acid sequences. also, antibodies generated against lysozyme ch failed to cross react with hen egg white lysozyme and vice versa. these lysozymes most likely represent examples of convergent evolution. | 1981 | 7238802 |
| the kinetics of the thyroid hormones and the peripheral conversion rate of thyroxine to triiodothyronine in acute liver insufficiency under experimental conditions. | the kinetics of triiodothyronine (t3) and thyroxine (t4) were studied in 20 ewes. ten were used as the control group, the other 10 received massive hepatic lesions induced by the ingestion of carbon tetrachloride. half of each group were i.v. injected with 125it3 or 125it4, following a plasma disappearance over 96 hours. the amount of hormone present in each plasma sample was determined by immunoextraction procedure. the data was adjusted to the open two-compartment model. the hepatic insufficie ... | 1981 | 7239425 |
| correlation between plasma thyroxine levels and corticosterone-binding activity in intact, ovariectomized, and ovariectomized estrogen-treated rats. | plasma levels of total thyroxine (t4) and corticosteroid-binding activity (cba) were determined in intact, ovariectomized, or ovariectomized, estrogen-treated rats during treatment with propylthiouracil (ptu) and following recovery from ptu. propylthiouracil treatment reduced the mean plasma t4 concentration to 9 ng/ml and the mean plasma cba to 39% of normal, while following recovery from ptu, the mean values for plasma t4 and cba were 56 ng/ml and 108%, respectively. there was a strong (r equa ... | 1981 | 7239427 |
| euthyroid "thyroxine toxicosis". | a survey was made of thyroid function tests on 1,153 patients screened for thyroid disease during a two-year period in a geriatric department; 13 percent of the test results fell outside the normal range. of 88 patients who showed above-normal results, only 12 presented with clinical features of thyrotoxicosis. in 37 patients, the biochemical findings indicated euthyroid "thyroxine toxicosis"; high values were found for serum thyroxine (t4) and the free thyroxine index (ft4i) but there were no c ... | 1981 | 7240624 |
| combined effects of neonatal thyroxine treatment and neonatal castration on sebum production in adult male rats. | newborn sprague-dawley rats were castrated within 24 h of birth and control animals were sham-operated. intact female rats were also included for comparison. one-half of the rats in each group was treated with 28 micrograms thyroxine (t4) daily for the first week of life. the secretion rate of sebum was measured at the age of 80 days from the amount of skin-surface lipids that could be extracted with acetone and which had been produced during 2 days. castration of rats at birth decreased the rat ... | 1981 | 7241010 |
| [synthesis and investigation of substituted iodothyronines with the aim of obtaining radiochemically stable 125i-tracers of high specific activity (author's transl)]. | various substituents were tested for their ability to replace 3'-iodine of t4 without affecting binding to t4 antibodies and without exchanging with 125i during synthesis of high specific activity t4. measured cross-reactivities of 3'-bromo-t3 and 3'-isopropyl-t3 relative to t4 were 85.6 and 8.9%, respectively, thus suggesting a high contribution of the ionised 4'-hydroxy group to antibody binding. the 3'-bromo substituent is not exchanged with 125i during labelling by the chloramine-t method. t ... | 1981 | 7241055 |
| [a 125i-thyronine derivative of high specific activity and radiochemical stability (pseudo-t4) (author's transl)]. | under the described reaction conditions for the synthesis of 125i-labelled thyroid hormones by the chloramine-t method, electrophilic substitution of the phenolic ring at positions 3' and 5' is accompanied by an exchange reaction. the proportions of mono- and diiodo-thyronine derivatives formed in this reaction depend on the specific activity of the 125i starting material. doubly labelled molecules are far less stable than mono products, because the radioactive decay of one iodine atom is follow ... | 1981 | 7241056 |
| therapeutic results in 265 cases of laryngeal cancer. | between january 1, 1970 and december 31, 1974, 265 patients were treated for laryngeal cancer at hôpital notre-dame, university of montreal. results have been studied according to initial stage and treatment. it seems that combined treatment significantly improves the survival rate in patients with t3 t4 lesions although distant metastasis appeared in 12.4 per cent of cases treated. there is a high incidence of distant metastasis in advanced lesions despite local control. | 1981 | 7241629 |
| [t3-hyperthyroidism under the aspects of secretion and peripheral production of thyroid hormones (author's transl)]. | in contrast to t4/t3-hyperthyroidism, where t4, t3, and r-t3 serum concentrations (sc) are elevated, in t3-hyperthyroidism the t3-sc alone is increased, whereas t4-sc is normal and r-t3 may be decreased. endogenous labelling of t4 with 131i is increased in t3-hyperthyroidism similarly as in t4/t3-hyperthyroidism, clearly reflecting an increased thyroidal formation of t4 in t3-hyperthyroidism. the contradiction of a normal sc to t4 in the presence of enhanced thyroidal formation of t4 may be expl ... | 1981 | 7241949 |
| thyroid function and thyroid hormone metabolism in elderly people. low t3-syndrome in old age? | t4-, t3- and reverse-t3 concentrations were measured in the sera of 365 subjects beyond the age of 65 in order to evaluate if the decrease of serum t3 frequently observed in old age can be attributed to old age per se or to concomitant nonthyroidal disease. the results obtained from a carefully selected healthy group of elderly people show that 1) total and free t3 levels are lower in senescence but well within the range for euthyroidism in younger healty controls;2) the decrease of serum t3 is ... | 1981 | 7241955 |
| treatment of carcinoma of the vocal cord. a review of 20 years experience. | at the university of california, san francisco, 323 patients were treated for carcinoma of the vocal cord between january 1956 and december 1975. patients with early t1 or t2 lesions were treated with radiotherapy or conservative surgery. patients with t3 or t4 lesions were treated with total laryngectomy, radiation alone, or combined therapy. of the 247 patients treated with definitive radiotherapy, initial control of the primary lesion was achieved in 100% of t1s, 80% of t1, 52% of t2, and 50% ... | 1981 | 7242207 |
| hepatic thyroxine (t4) uptake as a mechanism for regulation of triiodothyronine (t3) generation in rat liver slices. | 1981 | 7242256 | |
| interaction of thyroid status and diet on muscle protein breakdown in the rat, as measured by n tau-methylhistidine excretion. | the effects of thyroid status and of dietary protein and energy content on muscle protein breakdown have been compared in young rats, using urinary n tau-methylhistidine (3-methylhistidine; 3-mehis) output as a measure of myofibrillar protein breakdown. recently, thyroidectomized young rats receiving an adequate diet grew slowly and showed a reduction in 3-mehis output, relative to the weight of their leg muscles. when the thyroidectomized rats were given 2-5 microgram thyroxine (t4) per 100 g b ... | 1981 | 7242372 |
| [two cases of the diencephalic syndrome were reported with hormonal studies (author's transl)]. | two cases of the diencephalic syndrome were reported with hormonal studies. the first case was initially admitted at her age of 4 years and 10 months old. progressive visual disturbance and horizontal nystagmus had developed one year prior to the admission. her weight gain had stopped since 10 months old. partial removal of the hypothalamic pilocytic astrocytoma and 5,000 rad of lineac radiotherapy brought satisfactory effects on her previous symptoms. she was readmitted, however, at her age of ... | 1981 | 7242842 |
| [endemic goiter in austria's youth?]. | after 17 years the efficiency of iodine prophylaxis of endemic goiter (1 : 100000) in austria was checked by control field studies in 3 tyrolean towns n austria. the data obtained there were compared with those of 123 school age children from the iodine deficient endemic goiter area of the province of bolzano (italy). the results show a reduction in goiter incidence from 50 to 35% in the total population in austria, where goiter incidence in schoolchildren dropped from 45.9% to 12%. urinary iodi ... | 1981 | 7243330 |
| repair of psoralen plus near ultraviolet light damage in bacteriophages t3 and t4. | 1981 | 7243904 | |
| changes in thyroid function in pregnancy and with oral contraceptive use. | we measured t4, t3, t3 uptake, and tsh in nonpregnant patients, pregnant patients in the early and late first, and third trimesters, and patients using oral contraceptives. mean t4 levels increased and t3 uptake decreased during pregnancy. concentrations of t3 decreased in early pregnancy, then increased during the rest of pregnancy. thyroid-stimulating hormone (tsh) values were elevated in the second trimester. decreased t3 concentration in the early first trimester suggests increased use of t3 ... | 1981 | 7244747 |
| transaxillary sympathectomy (t2 to t4) for relief of vasospastic/sympathetic pain of upper extremities. | experience with 22 consecutive thoracic sympathectomies is presented. diagnoses included minor causalgia (12), mixed vasospastic and occlusive disease (4), raynaud's disease (4), and frostbite with ulceration (2). the operation was a transaxillary resection of ganglia t2, t3, and t4. both objective and subjective results indicate that this type of sympathectomy is as good as more extensive resections without the risk of a horner's syndrome. morbidity was minor but frequent and included dysesthes ... | 1981 | 7245038 |
| hyperthyroxinemia and hypotriiodothyroninemia with clinical euthyroidism. | a clinically euthyroid woman had substernal goiter and thrombocytopenia. there was a striking elevation in serum thyroxine (t4) level when the level of triiodothyronine (t3) ws low, reverse t3 (rt3) was normal i131 uptake was suppressed, and thyroid stimulating hormone (tsh) response to thyrotropin-releasing hormone (trh) was blunted. the elevation of t4 was transient and required no treatment. postmortem examination revealed a thyroid gland that showed only multinodular goiter. multiple factors ... | 1981 | 7246597 |
| the effect of surgery with carbohydrate infusion on circulating triiodothyronine and reverse triiodothyronine. | the blood levels of thyrotrophin (tsh), thyroxine (t4), triiodothyronine (t3), and reverse triiodothyronine (rt3) were measured in a group of patients undergoing cholecystectomy and receiving 2000 kcal of glucose daily throughout the study. tsh changes suggested a peroperative peak followed by a fall and subsequent rise. t4 showed no significant changes. t3 fell and rt3 rose postoperatively, with a highly significant fall in the t3/rt3 ratio (p less than 0.001). surgery and carbohydrate deprivat ... | 1981 | 7247276 |
| strain differences among rats in response to remington iodine-deficient diets. | male rats of five different strains (simonsen albino, wistar, long-evans, holtzman sprague-dawley, and charles river sprague-dawley) were tested for their response to the u.s. biochemical corp. remington low iodine diet containing 15-18 microgram i/kg. measurements made after the diet had been fed for 28-30 days indicated that simonsen albino and wistar strains consistently showed the greatest response, based on degree of thyroid enlargement, depletion of thyroidal iodine, reduction in serum t4, ... | 1981 | 7250050 |
| evidence for the absence of dna proofreading in hela cell nuclei. | [3h]2-aminopurine deoxyribonucleoside triphosphate and [32p]datp were added exogenously at equimolar concentrations to washed hela cell nuclei both in the presence and absence of cell cytoplasm. the observed ratio of 2-aminopurine/adenine deoxyribonucleotide incorporation into dna was about 12%, which is consistent with 2-aminopurine misinsertion frequencies measured in cell-free assays, for various dna polymerases including alpha-polymerase from calf thymus, escherichia coli polymerase i, and s ... | 1981 | 7251586 |
| effects of neonatal thyroxine, genotype, and noise on the ear and audiogenic seizures. | seyfried, glasser, and yu recently reported that the dba/2j mouse genotype, which is innately susceptible to audiogenic seizures, has high neonatal levels of thyroxine (t4) and that neonatal injections of t4 induce susceptibility in the c57bl/6j mouse. in the c57bl/6j mouse, neonatal t4 injections produced a temporary peripheral auditory dysfunction which appeared to be conductive in nature. a cochlear dysfunction was also seen in the dba/2j mouse and in the acoustically primed c57bl/6j mouse. s ... | 1981 | 7251951 |
| auditory brain stem responses in thyroid dysfunction. | a characteristic pattern of abr was observed in hyper-and hypofunction of the thyroid gland. the most conspicuous change took place in the bsct. its value correlated well with the level of serum t4. dynamic changes of abr pattern were recorded during the development of myxedema and on return to an euthyroid state. this preliminary study suggests that examinations of abr may serve as a tool in the overall assessment of thyroid status. | 1981 | 7252347 |
| cut-off for supplementary tsh testing in a t4 screening program for congenital hypothyroidism. | 1981 | 7252659 | |
| [radioimmunoassay for triiodothyronine and thyroxine--fundamental and clinical studies of amerlex t3, t4 (author's transl)]. | 1981 | 7253330 | |
| radioimmunological assays for triiodothyronine(t3) or thyroxine(t4) in sera containing antibodies against the hormones. | for serum samples containing antibodies in vivo against triiodothyronine or thyroxine, the radioimmunoassays in use may give highly erroneous results. we wanted to compare the effects of two different radioimmunoassay systems on such sera, and to develop a suitable extraction procedure for use before such assays. very different results were obtained with the use of single antibody or double antibody techniques on unextracted sera. the highest recoveries of total t3 and t4 from sera were found wi ... | 1981 | 7237736 |
| altered ontogenesis of muscarinic cholinergic receptor in mouse brain: effect of l-thyroxine and betamethasone. | the effects of l-t4 and betamethasone treatment of newborn mice on the development of the cholinergic muscarinic receptor in certain brain regions was studied using the potent labeled muscarinic antagonist [3h]4-n-methyl-piperidyl benzilate. treatment with both l-t4 and betamethasone caused an accelerated accumulation of muscarinic receptors in the cortex 16 days post partum, with a subsequent reduction in level at 30 days. in the cerebellum and caudate putamen, only betamethasone caused a simil ... | 1981 | 7238406 |
| functioning of the thyroid gland in sheep infected with trichostrongylus colubriformis. | radioactive tracers were used to to study the kinetic behaviour of inorganic iodine (i) and thyroxine (t4) in sheep (1) uninfected and fed ad libitum, (2) infected with trichostronglylus colubriformis and fed ad libitum and (3) uninfected but pair-fed to the infected animals. plasma concentration and pool size of inorganic i were each significantly lower in groups 2 and 3 than in 1. irreversible loss of inorganic i in both groups 2 and 3 was significantly greater than in 1. the turnover rate of ... | 1981 | 7244386 |
| control of puberty in female rats: the effect of ptu-induced hypothyroidism and systematic undernutrition. | sprague-dawley rats were fed purina lab chow with or without propylthiouracil (ptu), 0.001%, 0.01% or 0.1% ptu, ad libitum from weaning to vaginal opening. mean values for all pubertal measurements are included in tables 1 and 2. growth rate (mean +/- s.e.) was significantly reduced (neuman-keuls test; p less than 0.05 level) in all ptu-fed rats (controls 4.9 +/- 0.1 g/day, 0.001% ptu 4.2 +/- 0.2 g/day, 0.01% ptu 3.4 +/- 0.2 g/day, 0.1% ptu 2.5 +/- 0.1 g/day), while age at vaginal opening in rat ... | 1981 | 7254943 |
| improved rapid methodology for the isolation of nucleic acids from agarose gels. | improved methodology is presented with which dna may be rapidly isolated from agarose gels. hydroxyapatite is used to bind the nucleic acid after agarose solubilization and a sodium citrate buffer is used to elute the nucleic acid free of agarose. rapid concentration of the sample may then be effected by ethanol precipitation. purified oyster glycogen may be used as carrier in this regard and does not inhibit restriction endonucleases nor t4 dna ligase in the concentrations used. this methodolog ... | 1981 | 7255356 |
| [detection of inborn errors of metabolism in san pablo, brazil]. | the authors report their experience in populational screenings, first regarding hyperphenylalaninemias at the city of s paulo, by own programmation. in the same aminoacidopathies detection program, a similar methodology is being used in urine, in the children's health services of the state of s. paulo. the same urine procedure is being used to select iem of carbohydrates and mucopolysaccharides a programme similar to the one used for hyperphenylalaninemia is being performed for the detection of ... | 1981 | 7259843 |
| biofeedback regulation of temporal eeg alpha asymmetries. | integrated eeg alpha was recorded from t3 and t4. larger r alpha/l alpha ratios were defined as right asymmetry, relatively smaller ratios as left asymmetry. in different phases of the study, participants attempted to identify the presence of the eeg asymmetries and to produce the eeg asymmetries during auditory biofeedback, and were tested on hemisphere-specialized cognitive tasks while attempting to produce the eeg asymmetries. experiential descriptions of the eeg asymmetries were obtained thr ... | 1981 | 7260181 |
| thyroid abnormalities associated with treatment of malignant lymphoma. | the effects on the thyroid of radiation therapy to the neck and/or chemotherapy were investigated in 54 hodgkin's and 72 non-hodgkin's lymphoma patients. these patients had received radiation therapy with doses ranging from 2000 to 4000 rad (median 3600 rad) to the cervical or mantle fields and/or multiple-agent chemotherapy following usual staging procedures. palpable abnormalities of the thyroid were found in 15 patients. the patients with irradiation to the neck had a higher incidence of hypo ... | 1981 | 7260863 |
| serum levels of t4, t3, reverse t3, 3,3'-diiodothyronine and 3',5'-diiodothyronine in obesity, before and after jejuno-ileal bypass. | serum t4, 3,5,3'triiodothyronine (t3), 3,3',5'-triiodothyronine (reverse t3, rt3), 3,3'-diiodothyronine (3,3'-t2), 3',5'-diiodothyronine (3',5'-t2) and thyrotrophin (tsh) levels were studied in nineteen obese patients before and 6, 12, and 18, months after a jejuno-ileal bypass. before surgery, the obese patients had increased serum t3 levels compared with a group of lean, matched controls (median: 1.94 nmol/l v. 1.44 nmol/l, p less than 0.01). serum t3 decreased to normal (1.64 nmol/l) 18 month ... | 1981 | 7261411 |
| the effects of mild iodine deficiency on neonatal thyroid function. | in order to assess neonatal thyroid function in the endemic goitre areas of greece, t4 and tsh have been measured. previous studies had shown that in these endemic areas, adults had low t4 but normal tsh values, probably because of an increase in the serum t3 level. in this study, t4 and tsh were measured in dried blood spots from 259 neonates. the fifty-four full-term neonates from the greek endemic villages had a lower t4 value (8.8 +/- 0.66 micrograms/dl se) but a higher tsh (15.37 +/- 1.12 m ... | 1981 | 7261415 |
| thyroid hormones in acute myocardial infarction. | thyroid hormones were serially measured over a 2-week period in thirty-four consecutive patients with acute myocardial infarction (ami). a transient increase in plasma rt3 and a decrease in plasma t3 was found, with the maximum changes occurring on the third day after the onset of ami. the changes in plasma rt3 and t3 were greater in the seventeen patients with a complicated ami (mean peak sgot 145 mu/l) than in the seventeen patients with an uncomplicated ami (mean peak sgot 79 mu/l). a correla ... | 1981 | 7261419 |
| presence of l-thyroxine and 3,5,3'-triiodo-l-thyronine in tissues from thyroidectomized rats. | female rats were killed 15 days, 2 months, and 4 months after surgical thyroidectomy that was followed by injection of 100 microci 131i. the concentrations of t3 and t4 were measured in tissues (liver, kidney, brain, heart, and hindleg muscle) specific rias. results were compared to those found in intact rats. thyroidectomy resulted in severe hypothyroidism by 2 and 4 months after the operation, as assessed by undetectable levels of t4 and t3 in unextracted plasma, high circulating tsh, hypother ... | 1981 | 7262025 |
| results of 60co-teletherapy in oral cancer. | our study reports 282 oral cancer cases treated with 60co-teletherapy (tct), taken from 736 oral carcinomas treated with radiotherapy on the primary tumor from january 1959 to december 1970. they were mainly locally advanced cases which often had regional node involvement. in fact, during that period, the more advanced cases were submitted to tct. there were only 9 (3.2%) patients with t1 lesions, while there were 134 (47.5%) t2 and 139 (49.3%) t3, t4 cases; there were respectively 106 (37.6%) a ... | 1981 | 7256879 |
| dna repair-recombination functions in the dna processing pathway of bacteriophage t4. | 1981 | 7257182 | |
| [value of computer tomography in the staging of bladder and prostatic cancer]. | in carcinomas of the urinary bladder we regard a humpy contour of the outer wall of the bladder as a transmural growth of the tumour, i.e. stage t4. a retraction of the wall or a plateau phenomenon was assigned to an intramural infiltration (stage t2 or t3). contrary to the caudal lymphography in several cases changes in the nodes of the iliaca interna-group could be proved. the computer tomography seems to prove in such cases, in which the arteriography of the urinary bladder could not fulfil t ... | 1981 | 7257632 |
| suppressors of mutations in the rii gene of bacteriophage t4 affect promoter utilization. | homyk, rodriguez and weil (1976) have described t4 mutants, called sip, that partially suppress the inability of t4rii mutants to grow in lambda lysogens. we have found that mutants sip1 and sip2 are resistant to folate analogs and overproduce fh2 reductase. the results of recombination and complementation studies indicate that sip mutations are in the mot gene. like other mot mutations (mattson, richardson and goodin 1974; chace and hall 1975; sauerbier, hercules and hall 1976), the sip2 mutati ... | 1981 | 7262547 |
| secondary hypothyroidism in severe non thyroidal illness? | in severely ill patients of an intensive care unit overt peripheral thyroid hormone deficiency was noted in 22 of 33 subjects. the trh-test was performed in 7 of these 22 patients and was negative in all. thus, the laboratory data suggest secondary hypothyroidism. the laboratory diagnosis, however, could not be supported by clinical signs probably due to the short period of observation and to the strongly elevated body temperature of the respective patients. the pathogenetic mechanism is not cle ... | 1981 | 7262826 |
| dynamics of inhibition of iodothyronine deiodination during propylthiouracil treatment of thyrotoxicosis. | serum 3,3',5'-triiodothyronine (rt3), 3,5,3'-triiodothyronine (t3), thyroxine (t4) and propylthiouracil (ptu) were measured before and at short intervals for 8 hours after oral administration of 200 mg ptu to six patients with untreated thyrotoxicosis. the study was repeated on the 4th day of treatment with 200 mg ptu every 8 hours. six other patients with untreated thyrotoxicosis were studied after a single administration of 800 mg ptu. the results indicated that ptu inhibition of t4 deiodinati ... | 1981 | 7262827 |
| [identification of pasteurella serotypes by indirect hemagglutination]. | the indirect haemagglutination test was used for serological type identification of pasteurella strains. the pasteurella multocida strains were tested by parallel application of antigen production methods (common method plus hyaluronidase treatment). thirty-nine (72.2 per cent) of 54 pasteurella multocida strains, which had been obtained from cattle and swine, were serologically tested by the common technique of antigen production, their types being identified, while 42 (77.7 per cent) were test ... | 1981 | 7283648 |
| [influence of the spinal cord on the cerebral cortex nystagmogenic area]. | we have investigated the effect of section of the spinal cord, at cervical and thoracic levels, on the excitability of the nystagmogenic area in the rabbit. cervical transection (c2 level) induced a modification of excitability of this area since the threshold for cerebral eye nystagmus was lowered and the frequency of eye jerks was increased. dorsal spinal transection (t4 level) did not affect the cerebral nystagmogenic area. during electrical stimulation of the dorsal quadrants of the proximal ... | 1981 | 7284102 |