Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| lymphoepithelioma-like carcinoma of endometrium; a rare case report. | lymphoepithelioma -like carcinomas (lelcs) are tumors with histological features similar to those of lymphoepithelioma of nasopharynx. they have been described in many organs including female genital tract. their histology is characterized by sheets, nests and cords of large syncytial tumor cells containing round nuclei with prominent nucleoli and dense lymphoplasmacytic infiltrate in the stoma. the association of epstein-barr virus (ebv) with lelcs has not been observed in western patients. but ... | 2015 | 26405421 |
| a novel risk locus at 6p21.3 for epstein-barr virus-positive hodgkin lymphoma. | a proportion of the genetic variants involved in susceptibility to hodgkin lymphoma differ by the tumor's epstein-barr virus (ebv) status, particularly within the mhc region. | 2015 | 26404960 |
| elevated concentrations of serum immunoglobulin free light chains in systemic lupus erythematosus patients in relation to disease activity, inflammatory status, b cell activity and epstein-barr virus antibodies. | in this study, we examined the concentration of serum immunoglobulin free light chains (flcs) in systemic lupus erythematosus (sle) patients and investigated its association with various disease parameters in order to evaluate the role of flcs as a potential biomarker in sle. furthermore, flcs' association with epstein-barr virus (ebv) antibodies was examined. | 2015 | 26402865 |
| modulation of microrna cluster mir-183-96-182 expression by epstein-barr virus latent membrane protein 1. | epstein-barr virus (ebv) is an oncogenic human herpesvirus involved in the pathogenesis of burkitt's lymphoma (bl) and various other lymphoproliferative disorders. in bl, ebv protein expression is restricted to ebv nuclear antigen 1 (ebna1), but small noncoding rnas such as ebv-encoded small rnas (ebers) and micrornas (mirnas) can also be detected. mirnas play major roles in crucial processes such as proliferation, differentiation, and cell death. it has recently become clear that alterations in ... | 2015 | 26401047 |
| nasopharyngeal carcinoma: review of the literature with a focus on therapeutical implications. | nasopharyngeal carcinoma (npc) is a rare neoplasm which is associated with epstein-barr virus (ebv). first of all, we reviewed the literature on npc treatment. radio/chemotherapy is currently the gold standard but unfortunately is affected by rates of failure ranging from 7% up to 58%. because npc development is promoted by the ebv latent life cycle, ebv-targeted treatments were investigated. firstly, forcing cytolytic virus activation through administration of gemcitabine and/or valproic acid b ... | 2015 | 26397290 |
| lmp1 promotes nasal nk/t-cell lymphoma cell function by eif4e via nf-κb pathway. | nasal natural killer t-cell lymphoma (nktl) is a highly malignant tumor that is closely associated with epstein-barr virus (ebv) infection. latent membrane protein 1 (lmp1) is encoded by ebv and plays an important role in ebv-induced cell transformation. therefore, we assessed the function of lmp1 as a stimulant of nktl progression and the underlying mechanism. a human ebv-positive nktl cell line (snk-6) was transfected with pcdna3.1-lmp1, lv-lmp1 shrna or lv-eukaryotic translation initiation fa ... | 2015 | 26397141 |
| increased serum levels of interleukin-10 predict poor prognosis in extranodal natural killer/t-cell lymphoma patients receiving asparaginase-based chemotherapy. | there are currently no prognostic biomarkers for extranodal natural killer/t-cell lymphoma (enktl) patients receiving asparaginase-based chemotherapy. interleukin-10 (il-10) is a pleiotropic cytokine that is involved in the stimulation and suppression of immune responses and influences the prognosis of different subtypes of lymphoma. we retrospectively analyzed 98 newly diagnosed patients with enktl receiving asparaginase-based chemotherapy. baseline serum il-10 levels were tested with sandwich ... | 2015 | 26396532 |
| the epstein-barr virus (ebv) in t cell and nk cell lymphomas: time for a reassessment. | while epstein-barr virus (ebv) was initially discovered and characterized as an oncogenic virus in b cell neoplasms, it also plays a complex and multifaceted role in t/nk cell lymphomas. in b cell lymphomas, ebv-encoded proteins have been shown to directly promote immortalization and proliferation through stimulation of the nf-κb pathway and increased expression of anti-apoptotic genes. in the context of mature t/nk lymphomas (mtnkl), with the possible exception on extranodal nk/t cell lymphoma ... | 2015 | 26449716 |
| case report: a diagnostically challenging conjunctival mass caused by the epstein-barr virus. | we present a paediatric case of infectious mononucleosis in a 13-year old, manifesting with follicular conjunctivitis and a conjunctival mass in one eye with no evidence of leucocytosis on the blood count. the diagnosis was confirmed following surgical excision and biopsy. the case represented a diagnostic challenge due to its atypism and given the steady increase in the prevalence of ebv-related ocular diseases in the last years, this report can serve as an example to prompt earlier serological ... | 2015 | 26447043 |
| spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (hiv)-negative patient. | plasmablastic lymphoma (pbl) is an aggressive lymphoma commonly associated with human immunodeficiency virus (hiv) infection. herein we describe a rare case of pbl that spontaneously regressed. an 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. he had no significant past medical history, and a screening test for hiv was negative. imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bo ... | 2015 | 26445485 |
| primary pulmonary lymphomas. | primary lung lymphoma (pll) is a rare disease that comprises <0.5% of all primary lung tumors. it is defined as lymphoma confined to the lung with or without hilar lymph node involvement at the time of diagnosis or up to 3 months thereafter. patients with pll may be asymptomatic or manifest nonspecific clinical symptoms, for example, cough, chest pain, and dyspnea. some individuals may be immunosupressed or have an autoimmune disorder. radiologically, pll can mimic pneumonia, lung carcinoma, or ... | 2015 | 26452211 |
| memory b-cell reconstitution following allogeneic hematopoietic stem cell transplantation is an ebv-associated transformation event. | allogeneic stem cell transplantation (allo-hsct) provides a unique opportunity to track epstein-barr virus (ebv) infection in the context of the reconstituting b-cell system. although many allo-hsct recipients maintain low or undetectable levels of ebv dna posttransplant, a significant proportion exhibit elevated and rapidly increasing ebv loads which, if left untreated, may lead to potentially fatal ebv-associated posttransplant lymphoproliferative disease. intriguingly, this high-level ebv rea ... | 2015 | 26450987 |
| cord blood t cells mediate enhanced antitumor effects compared with adult peripheral blood t cells. | unrelated cord blood transplantation (cbt) without in vivo t-cell depletion is increasingly used to treat high-risk hematologic malignancies. following t-replete cbt, naïve cb t cells undergo rapid peripheral expansion with memory-effector differentiation. emerging data suggest that unrelated cbt, particularly in the context of hla mismatch and a t-replete graft, may reduce leukemic relapse. to study the role of cb t cells in mediating graft-versus-tumor responses and dissect the underlying immu ... | 2015 | 26450984 |
| a simple procedure for the extraction of dna from long-term formalin-preserved brain tissues for the detection of ebv by pcr. | long-term formalin fixed brain tissues are potentially an important source of material for molecular studies. ironically, very few protocols have been published describing dna extraction from such material for use in pcr analysis. in our attempt to investigate the role of epstein-barr virus (ebv) in the pathogenesis of multiple sclerosis (ms), extracting pcr quality dna from brain samples fixed in formalin for 2-22 years, proved to be very difficult and challenging. as expected, dna extracted fr ... | 2015 | 26450268 |
| fatal epstein-barr virus reactivation in an acquired aplastic anemia patient treated with rabbit antithymocyte globulin and cyclosporine a. | epstein-barr virus (ebv) associated lymphoproliferative disorder (lpd) after immunosuppressive therapy for aplastic anemia (aa) is extremely rare in a nontransplant setting and has not been well described. this report describes a severe aa patient in whom fatal ebv-lpd developed after being treated with rabbit antithymocyte globulins (atg) and cyclosporine a (csa). an 81-year-old man was diagnosed as having severe aa. he was started on csa followed by administration of atg for five consecutive d ... | 2015 | 26425376 |
| the mycotoxin aflatoxin b1 stimulates epstein-barr virus-induced b-cell transformation in in vitro and in vivo experimental models. | although epstein-barr virus (ebv) infection is widely distributed, certain ebv-driven malignancies are geographically restricted. ebv-associated burkitt's lymphoma (ebl) is endemic in children living in sub-saharan africa. this population is heavily exposed to food contaminated with the mycotoxin aflatoxin b1 (afb1). here, we show that exposure to afb1 in in vitro and in vivo models induces activation of the ebv lytic cycle and increases ebv load, two events that are associated with an increased ... | 2015 | 26424750 |
| nasopharyngeal carcinoma: an evolving role for the epstein-barr virus. | the epstein-barr herpesvirus (ebv) is an important human pathogen that is closely linked to several major malignancies including the major epithelial tumor, undifferentiated nasopharyngeal carcinoma (npc). this important tumor occurs with elevated incidence in specific areas, particularly in southern china but also in mediterranean africa and some regions of the middle east. regardless of tumor prevalence, undifferentiated npc is consistently associated with ebv. the consistent detection of ebv ... | 2015 | 26424653 |
| the role of ebv in the pathogenesis of diffuse large b cell lymphoma. | epstein-barr virus (ebv) infection is a common feature of b cell lymphoproliferative disorders (lpds), including diffuse large b cell lymphoma. approximately 10 % of dlbcls are ebv-positive, with the highest incidence in immunocompromised and elderly patients. here, we review the clinical, genetic, and pathologic characteristics of dlbcl and discuss the molecular role of ebv in lymphoma tumorigenesis. using ebv-positive dlbcl of the elderly as a model, we describe the key features of ebv-positiv ... | 2015 | 26424652 |
| contribution of the epstein-barr virus to the pathogenesis of hodgkin lymphoma. | the morphology of the pathognomonic hodgkin and reed-sternberg cells (hrs) of hodgkin lymphoma was described over a century ago, yet it was only relatively recently that the b-cell origin of these cells was identified. in a proportion of cases, hrs cells harbour monoclonal forms of the b lymphotropic epstein-barr virus (ebv). this review summarises current knowledge of the pathogenesis of hodgkin lymphoma with a particular emphasis on the contribution of ebv. | 2015 | 26424651 |
| burkitt's lymphoma. | endemic burkitt's lymphoma (bl) remains the most prevalent pediatric cancer in sub-saharan africa even though it was the first human cancer with a viral etiology described over 50 years ago. epstein-barr virus (ebv) was discovered in a bl tumor in 1964 and has since been implicated in other malignancies. the etiology of endemic bl has been linked to ebv and plasmodium falciparum malaria co-infection. while epidemiologic studies have yielded insight into ebv infection and the etiology of endemic ... | 2015 | 26424650 |
| primary immunodeficiencies associated with ebv disease. | epstein-barr virus (ebv) infects nearly all humans and usually is asymptomatic, or in the case of adolescents and young adults, it can result in infectious mononucleosis. ebv-infected b cells are controlled primarily by nk cells, inkt cells, cd4 t cells, and cd8 t cells. while mutations in proteins important for b cell function can affect ebv infection of these cells, these mutations do not result in severe ebv infection. some genetic disorders affecting t and nk cell function result in failure ... | 2015 | 26424649 |
| infectious mononucleosis. | infectious mononucleosis is a clinical entity characterized by sore throat, cervical lymph node enlargement, fatigue, and fever most often seen in adolescents and young adults and lasting several weeks. it can be caused by a number of pathogens, but this chapter only discusses infectious mononucleosis due to primary epstein-barr virus (ebv) infection. ebv is a γ-herpesvirus that infects at least 90% of the population worldwide. the virus is spread by intimate oral contact among teenagers and you ... | 2015 | 26424648 |
| epstein-barr virus: from the detection of sequence polymorphisms to the recognition of viral types. | the epstein-barr virus is etiologically linked with the development of benign and malignant diseases, characterized by their diversity and a heterogeneous geographic distribution across the world. the virus possesses a 170-kb-large genome that encodes for multiple proteins and non-coding rnas. early on there have been numerous attempts to link particular diseases with particular ebv strains, or at least with viral genetic polymorphisms. this has given rise to a wealth of information whose value ... | 2015 | 26424646 |
| the epigenetic life cycle of epstein-barr virus. | ever since the discovery of epstein-barr virus (ebv) more than 50 years ago, this virus has been studied for its capacity to readily establish a latent infection, which is the prominent hallmark of this member of the herpesvirus family. ebv has become an important model for many aspects of herpesviral latency, but the molecular steps and mechanisms that lead to and promote viral latency have only emerged recently. it now appears that the virus exploits diverse facets of epigenetic gene regulatio ... | 2015 | 26424645 |
| chromatin structure of epstein-barr virus latent episomes. | ebv latent infection is characterized by a highly restricted pattern of viral gene expression. ebv can establish latent infections in multiple different tissue types with remarkable variation and plasticity in viral transcription and replication. during latency, the viral genome persists as a multi-copy episome, a non-integrated-closed circular dna with nucleosome structure similar to cellular chromosomes. chromatin assembly and histone modifications contribute to the regulation of viral gene ex ... | 2015 | 26424644 |
| epstein-barr virus strain variation. | what is wild-type epstein-barr virus and are there genetic differences in ebv strains that contribute to some of the ebv-associated diseases? recent progress in dna sequencing has resulted in many new epstein-barr virus (ebv) genome sequences becoming available. ebv isolates worldwide can be grouped into type 1 and type 2, a classification based on the ebna2 gene sequence. type 1 transforms human b cells into lymphoblastoid cell lines much more efficiently than type 2 ebv and molecular mechanism ... | 2015 | 26424643 |
| ebv-specific immune response: early research and personal reminiscences. | early research on epstein-barr virus (ebv) developed from serological observations that were made soon after the discovery of the virus. indeed, the definition of the humoral response to a variety of ebv proteins dominated the early literature and was instrumental in providing the key evidence for the association of the virus with infectious mononucleosis (im), burkitt's lymphoma (bl), and nasopharyngeal carcinoma (npc). each of these disease associations involved a distinct pattern of serologic ... | 2015 | 26424642 |
| tumor associations of ebv--historical perspectives. | this is a brief history of our collaborative work with werner and gertrude henle, francis wiener, george and yanke manolov, and others on the association of epstein-barr virus (ebv) with burkitt lymphoma and other human tumors. special emphasis is put on the question where ebv is a true cancer virus. | 2015 | 26424641 |
| why and how epstein-barr virus was discovered 50 years ago. | an account is given of the experiences and events which led to a search being undertaken for a causative virus in the recently described burkitt's lymphoma and of the steps which ultimately culminated in the discovery of the new human herpesvirus which came to be known as epstein-barr virus (ebv). | 2015 | 26424640 |
| fulminant adenovirus hepatitis after hematopoietic stem cell transplant: retrospective real-time pcr analysis for adenovirus dna in two cases. | viral infection is one of the major causes of mortality in patients undergoing hematopoietic stem cell transplant (hsct). systemic infection of adenovirus (adv) has emerged as a not uncommon viral infection with significant morbidity and mortality as with cytomegalovirus and epstein-barr virus infection. routine surveillance for these viruses has become a clinical practice and subsequent preemptive therapy improves patients' outcomes; however, the effectiveness of preemptive therapy for adv has ... | 2015 | 26423689 |
| profiling of ebv-encoded micrornas in ebv-associated hemophagocytic lymphohistiocytosis. | epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) is a life-threatening complication of ebv infection. micrornas (mirnas) were small non-coding rna, and ebv could encode mirnas that are involved in the progression of infection. however, the profiles of ebv-mirnas in ebv-hlh were unknown. here, we aimed to profile the expression of ebv-mirnas in children with ebv-hlh by analyzing 44 known ebv-mirnas, encoded within the bamhi fragment h rightward open reading frame 1 (bhrf ... | 2015 | 26423217 |
| [influence of doxorubicin and etoposide on the cd 95 mediated apoptosis in ebv infected lymphoma cells bl-41 and dg-75]. | the aim of work was to study the effect of anticancer drugs on the process of cd 95 mediated apoptosis in bl-41 and dg-75 infected with epstein-barr virus. studies of the effect of anticancer drugs "doxorubicin" "ebewe" and "vepesid" (etoposide) on the apoptosis in ebv infected cells using cytomorphological methods, spectrophotometry and pcr carried out. the influence of the tested drugs in cell culture was assessed by calculating the cc50. it was shown that it was 20 μg ml both for etoposide an ... | 2015 | 26422926 |
| diagnosis and management of cutaneous b-cell lymphoma. | the diagnosis of primary cutaneous b-cell lymphoma (cbcl) requires that the search for a more widespread lymphoma has been negative. the clinical presentation, outlook, and treatment options of the common types of cbcls, with emphasis on differences or similarities to their nodal counterparts, are discussed. treatment may range from observation to topical therapies to systemic therapies, depending on the histology, degree and area of skin involvement, patient performance, and comorbidities. rare ... | 2015 | 26433853 |
| a novel method to expand large numbers of cd56(+) natural killer cells from a minute fraction of selectively accessed cryopreserved cord blood for immunotherapy after transplantation. | umbilical cord blood transplantation (ucbt) is increasingly used to treat acute leukemias. ucb units are thawed and infused in their entirety at transplant, precluding later use as immunotherapy to prevent or treat leukemia relapse. | 2015 | 26432560 |
| elevated il-35 in bone marrow of the patients with acute myeloid leukemia. | acute myeloid leukemia (aml) is the most common hematological malignancy in adults, but the etiology of it remains poorly understood. il-35 is a recently described cytokine composed of an il-12 subunit p35 and an il-27 subunit epstein-barr virus induced gene 3 (ebi3), and has an immunosuppressive effect on inflammation through induction of regulatory t cells (tregs) and suppression of th1 and th17. recently, we have illustrated that concentrations of il-35 in peripheral blood are up-regulated in ... | 2015 | 26431888 |
| differentiation-dependent klf4 expression promotes lytic epstein-barr virus infection in epithelial cells. | epstein-barr virus (ebv) is a human herpesvirus associated with b-cell and epithelial cell malignancies. ebv lytically infects normal differentiated oral epithelial cells, where it causes a tongue lesion known as oral hairy leukoplakia (ohl) in immunosuppressed patients. however, the cellular mechanism(s) that enable ebv to establish exclusively lytic infection in normal differentiated oral epithelial cells are not currently understood. here we show that a cellular transcription factor known to ... | 2015 | 26431332 |
| characterization of the rapamycin-inducible ebv lmp1 activation system. | epstein-barr virus (ebv) latent infection membrane protein 1 (lmp1) is required for ebv-mediated b lymphocyte transformation into proliferating lymphoblastoid cell lines (lcl). lmp1 oligomerizes spontaneously in membrane lipid rafts via its transmembrane domain and constitutively activates signal transduction pathways, including nf-κb, p38 mitogen-activated protein kinase (mapk), and c-jun n-terminal kinase (jnk). since lmp1 mimics the tumor necrosis factor receptor (tnfr), cd40, it may be effec ... | 2015 | 26428925 |
| the biology and clinical utility of ebv monitoring in blood. | epstein-barr virus (ebv) dna in blood can be quantified in peripheral blood mononuclear cells, in circulating cell-free (ccf) dna specimens, or in whole blood. ccf viral dna may be actively released or extruded from viable cells, packaged in virions or passively shed from cells during apoptosis or necrosis. in infectious mononucleosis, viral dna is detected in each of these kinds of specimens, although it is only transiently detected in ccf specimens. in nasopharyngeal carcinoma, ccf ebv dna is ... | 2015 | 26428386 |
| the development of prophylactic and therapeutic ebv vaccines. | over the last century, the development of effective vaccine approaches to treat a number of viral infections has provided the impetus for the continual development of vaccine platforms for other viral infections, including epstein-barr virus (ebv). the clinical manifestations associated with ebv infection occur either following primary infection, such as infectious mononucleosis, or following an extended period of latency, primarily the ebv-associated malignancies and potentially including a num ... | 2015 | 26428385 |
| adoptive t-cell immunotherapy. | epstein-barr virus (ebv) is associated with a range of malignancies involving b cells, t cells, natural killer (nk) cells, epithelial cells, and smooth muscle. all of these are associated with the latent life cycles of ebv, but the pattern of latency-associated viral antigens expressed in tumor cells depends on the type of tumor. ebv-specific t cells (ebvsts) have been explored as prophylaxis and therapy for ebv-associated malignancies for more than two decades. ebvsts have been most successful ... | 2015 | 26428384 |
| ebv infection of mice with reconstituted human immune system components. | epstein-barr virus (ebv) was discovered 50 years ago as the first candidate human tumor virus. since then, we have realized that this human γ-herpesvirus establishes persistent infection in the majority of adult humans, but fortunately causes ebv-associated diseases only in few individuals. this is an incredible success story of the human immune system, which controls ebv infection and its transforming capacity for decades. a better understanding of this immune control would not only benefit pat ... | 2015 | 26428383 |
| non-human primate lymphocryptoviruses: past, present, and future. | epstein-barr virus (ebv) orthologues from non-human primates (nhps) have been studied for nearly as long as ebv itself. cross-reactive sera and dna hybridization studies provided the first glimpses of the closely related herpesviruses that belonged to the same gamma-1 herpesvirus, or lymphocryptovirus, genus, as ebv. over the years, detailed molecular and sequence analyses of lcvs that infect humans and other nhps revealed similar colinear genome structures and homologous viral proteins expresse ... | 2015 | 26428382 |
| immune evasion by epstein-barr virus. | epstein-bar virus (ebv) is widespread within the human population with over 90% of adults being infected. in response to primary ebv infection, the host mounts an antiviral immune response comprising both innate and adaptive effector functions. although the immune system can control ebv infection to a large extent, the virus is not cleared. instead, ebv establishes a latent infection in b lymphocytes characterized by limited viral gene expression. for the production of new viral progeny, ebv rea ... | 2015 | 26428381 |
| t-cell responses to ebv. | epstein-barr virus (ebv) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world's population. despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. nevertheless, the potent growth transforming ability of ebv means the virus has the potential to cause malignancies in infected individuals. indeed, ebv is thought to cause 1% of human malignancies, equating to ... | 2015 | 26428380 |
| epstein-barr virus-specific humoral immune responses in health and disease. | epstein-barr virus (ebv) is widely distributed in the world and associated with a still increasing number of acute, chronic, malignant and autoimmune disease syndromes. humoral immune responses to ebv have been studied for diagnostic, pathogenic and protective (vaccine) purposes. these studies use a range of methodologies, from cell-based immunofluorescence testing to antibody-diversity analysis using immunoblot and epitope analysis using recombinant or synthetic peptide-scanning. first, the ind ... | 2015 | 26428379 |
| innate immune recognition of ebv. | the ability of epstein-barr virus (ebv) to establish latency despite specific immune responses and to successfully persist lifelong in the human host shows that ebv has developed powerful strategies and mechanisms to exploit, evade, abolish, or downsize otherwise effective immune responses to ensure its own survival. this chapter focuses on current knowledge on innate immune responses against ebv and its evasion strategies for own benefit and summarizes the questions that remain to be tackled. i ... | 2015 | 26428378 |
| epstein-barr virus lytic cycle reactivation. | epstein-barr virus, which mainly infects b cells and epithelial cells, has two modes of infection: latent and lytic. epstein-barr virus infection is predominantly latent; however, lytic infection is detected in healthy seropositive individuals and becomes more prominent in certain pathological conditions. lytic infection is divided into several stages: early gene expression, dna replication, late gene expression, assembly, and egress. this chapter summarizes the most recent progress made toward ... | 2015 | 26428377 |
| viral entry. | epstein-barr virus primarily, though not exclusively, infects b cells and epithelial cells. many of the virus and cell proteins that are involved in entry into these two cell types in vitro have been identified, and their roles in attachment and fusion are being explored. this chapter discusses what is known about entry at the cellular level in vitro and describes what little is known about the process in vivo. it highlights some of the questions that still need to be addressed and considers som ... | 2015 | 26428376 |
| latent membrane protein 2 (lmp2). | lmp2a is an ebv-encoded protein with three domains: (a) an n-terminal cytoplasmic domain, which has py motifs that bind to ww domain-containing e3 ubiquitin ligases and an itam that binds to sh2 domain-containing proteins, (b) a transmembrane domain with 12 transmembrane segments that localizes lmp2a in cellular membranes, and (c) a 27-amino acid c-terminal domain which mediates homodimerization and heterodimerization of lmp2 protein isoforms. the most prominent two isoforms of the protein are l ... | 2015 | 26428374 |
| the latent membrane protein 1 (lmp1). | almost exactly twenty years after the discovery of epstein-barr virus (ebv), the latent membrane protein 1 (lmp1) entered the ebv stage, and soon thereafter, it was recognized as the primary transforming gene product of the virus. lmp1 is expressed in most ebv-associated lymphoproliferative diseases and malignancies, and it critically contributes to pathogenesis and disease phenotypes. thirty years of lmp1 research revealed its high potential as a deregulator of cellular signal transduction path ... | 2015 | 26428373 |
| the ebna3 family: two oncoproteins and a tumour suppressor that are central to the biology of ebv in b cells. | epstein-barr virus nuclear antigens ebna3a , ebna3b and ebna3c are a family of three large latency-associated proteins expressed in b cells induced to proliferate by the virus. together with the other nuclear antigens (ebna-lp, ebna2 and ebna1), they are expressed from a polycistronic transcription unit that is probably unique to b cells. however, compared with the other ebnas, hitherto the ebna3 proteins were relatively neglected and their roles in ebv biology rather poorly understood. in recen ... | 2015 | 26428372 |
| ebna2 and its coactivator ebna-lp. | while all herpesviruses can switch between lytic and latent life cycle, which are both driven by specific transcription programs, a unique feature of latent ebv infection is the expression of several distinct and well-defined viral latent transcription programs called latency i, ii, and iii. growth transformation of b-cells by ebv in vitro is based on the concerted action of epstein-barr virus nuclear antigens (ebnas) and latent membrane proteins(lmps). ebv growth-transformed b-cells express a v ... | 2015 | 26428371 |
| targeted therapy for epstein-barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation. | the constant presence of the viral genome in epstein-barr virus (ebv)-associated gastric cancers (ebvagcs) suggests the applicability of novel ebv-targeted therapies. the antiviral nucleoside drug, ganciclovir (gcv), is effective only in the context of the viral lytic cycle in the presence of ebv-encoded thymidine kinase (tk)/protein kinase (pk) expression. in this study, screening of the johns hopkins drug library identified gemcitabine as a candidate for combination treatment with gcv. pharmac ... | 2015 | 26427042 |
| epstein-barr virus latency: current and future perspectives. | ebv drives resting b cells to continuous proliferating latently infected cells. a restricted program of viral transcription contributes to latency and cell proliferation important for growth transformation. recent interest in latency and transformation has provided new data about the roles of the ebv encoded latent proteins and non-coding rnas. we broadly describe the transcription, epigenetic, signaling and super-enhancer functions of the latent nuclear antigens in regulating cellular transcrip ... | 2015 | 26453799 |
| no association of multiple sclerosis activity and progression with ebv or tobacco use in benefit. | to evaluate whether epstein-barr virus (ebv) immunoglobulin g (igg) antibody levels or tobacco use were associated with conversion to multiple sclerosis (ms) or ms progression/activity in patients presenting with clinically isolated syndrome (cis). | 2015 | 26453645 |
| epstein-barr virus-infected cells release fas ligand in exosomal fractions and induce apoptosis in recipient cells via the extrinsic pathway. | epstein-barr virus (ebv; human herpesvirus 4) is an oncogenic herpesvirus implicated in the pathogenesis of several human malignancies. a number of recent studies indicate that ebv can manipulate the local microenvironment by excreting viral and cellular components in nanovesicles called exosomes. in this study, we investigated the impact of ebv-derived exosomes on apoptosis of recipient cells and the molecular pathway involved in this process. exosomes from ebv-infected but not from non-infecte ... | 2015 | 26467838 |
| unique presentation of a plasmablastic lymphoma superficially involving the entire large bowel. | plasmablastic lymphoma (pbl) is an uncommon, aggressive b-cell lymphoma mostly occurring in the oral cavity of human immunodeficiency virus (hiv) positive patients, but also described in extraoral sites and in hiv negative patients. one of the relatively common extraoral sites of pbl is the gastrointestinal (gi) tract. few cases of pbl have been reported in association with inflammatory bowel disease (ibd). here, we describe the unique presentation of a pbl involving the large bowel superficiall ... | 2015 | 26459980 |
| methotrexate-associated lymphoproliferative disorder presenting as extranodal nk/t-cell lymphoma arising in the lungs. | patients having rheumatoid arthritis (ra) treated with methotrexate (mtx) are at an increased risk of developing lymphoproliferative disorder (lpd). epstein-barr virus (ebv) sometimes contributes to the development of mtx-associated lpd. herein, we report the case of a 64-year-old japanese woman with ra who showed complications of ebv-positive mtx-associated lpd. this case is exceedingly rare in that the lpd was confined to the lungs and its subclassification was extranodal nk/t-cell lymphoma. o ... | 2015 | 26459854 |
| murine gammaherpesvirus 68 orf35 is required for efficient lytic replication and latency. | murine gammaherpesvirus (mhv) 68, a natural pathogen of field mice, is related to human gammaherpesviruses, epstein–barr virus (ebv; human herpesvirus 4) and kaposi’s sarcoma-associated herpesvirus (kshv; human herpesvirus 8). the orf35 of mhv-68 and its homologues of ebv and kshv are located in the gene cluster composed of orf34–orf38 in which each gene overlaps with adjacent genes. although mhv-68 orf35 was reported to be an essential gene, its function during infection is presently unknown. i ... | 2015 | 26459827 |
| the full-length dna sequence of epstein barr virus from a human gastric carcinoma cell line, snu-719. | the consistent presence of epstein-barr virus (ebv) in malignant cells of ebv-associated gastric carcinoma (ebvagc) suggests it plays an important role during the development of ebvagc. however, the entire genomic sequence of ebv from ebvagc has yet to be determined. this study first determined, annotated, and analyzed the full genomic sequence of ebv from the naturally infected gastric carcinoma cell line snu-719 using next-generation sequencing and comparative analyses. in consistent with the ... | 2015 | 26459384 |
| long-term tumor-free survival with untreated primary diffuse large b-cell lymphoma of the tonsil: a report of 9 cases. | in some cases, long-term tumor-free survival might be possible for untreated primary diffuse large b-cell lymphoma (dlbcl) of the tonsil. here, we report of 9 untreated patients who had primary tonsil dlbcl with long-term tumor-free survival. all these patients were children or young adults (4 male and 5 female individuals; ages: 6 to 38 y, median age: 25 y) with clinically evident swollen tonsils or papillary neoplasms. tonsillectomy and biopsies indicated partial structural destruction of the ... | 2015 | 26457354 |
| amino acid variation in hla class ii proteins is a major determinant of humoral response to common viruses. | the magnitude of the human antibody response to viral antigens is highly variable. to explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin g response to 14 pathogenic viruses in 2,363 immunocompetent adults. significant associations were observed in the major histocompatibility complex region on chromosome 6 for influenza a virus, epstein-barr virus, jc polyomavirus, and merkel cell polyomavirus. using local imputation and ... | 2015 | 26456283 |
| composite primary breast diffuse large b-cell lymphoma and t lymphoblastic leukemia/lymphoma: report of a case and review of literature. | we reported a rare case of composite diffuse large b-cell lymphoma and t lymphoblastic leukemia/lymphoma (t-lbl) in a 46-year-old woman with progressive enlargement of the breast lump. the patient initially sought care at a local hospital with a single left breast lump without any other physical examination findings. histopathological analysis of which revealed a diffuse infiltration of tumor cells that were rich in cytoplasm with vesicular chromatin and prominent nucleoli. further analysis of i ... | 2015 | 26464729 |
| extranodal nk/t-cell lymphoma, nasal type: a case report of 7-year natural course and review of literature. | we present our experience a vary case of extranodal natural killer (nk)/t-cell lymphomas, nasal type (enkl) who survived for 7 years, and review the recent advances on the differential diagnosis. | 2015 | 26464728 |
| [clinicopathological features and prognositic analysis of epstein-barr virus- positive diffuse large b-cell lymphoma in elderly: 7 cases report and literatures review]. | 2015 | 26462644 | |
| prevalence of human papillomavirus (hpv) and epstein-barr virus (ebv) in oral and oropharyngeal squamous cell carcinoma in south-eastern poland. | the aim of this study was to analyze the prevalence of hpv and ebv in oral and oropharyngeal squamous cell carcinoma in south-eastern poland. the correlation between viral infection, oscc, alcohol use, tobacco smoking, demographic data (gender, age, place of residence), anatomic location, pre-treatment staging, evidence of metastases to lymph nodes, and grading was also investigated. | 2015 | 26462255 |
| sequence variation analysis of epstein-barr virus nuclear antigen 1 gene in the virus associated lymphomas of northern china. | epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is the only viral protein expressed in all ebv-positive tumors as it is essential for the maintenance, replication and transcription of the virus genome. according to the polymorphism of residue 487 in ebna1 gene, ebv isolates can be classified into five subtypes: p-ala, p-thr, v-val, v-leu and v-pro. whether these ebna1 subtypes contribute to different tissue tropism of ebv and are consequently associated with certain malignancies remain to be ... | 2015 | 26460969 |
| primary cns lymphoproliferative disease, mycophenolate and calcineurin inhibitor usage. | immunosuppression for solid organ transplantation increases lymphoproliferative disease risk. while central nervous system (cns) involvement is more rare, we noticed an increase in primary cns (pcns) disease. to investigate a potential association with the immunosuppressive regimen we identified all post-transplant lymphoproliferative disease (ptld) cases diagnosed over a 28-year period at our institution (174 total, 29 pcns) and all similar cases recorded in a united network for organ sharing-o ... | 2015 | 26460822 |
| high viral loads of epstein-barr virus dna in peripheral blood of patients with chronic lymphocytic leukemia associated with unfavorable prognosis. | epstein-barr virus (ebv) is a ubiquitous γ-herpesvirus that infects more than 90% of the world population. the potential involvement of ebv in the clinical course of chronic lymphocytic leukemia (cll) remains unexplained. the aim of this study was to determine whether ebv-dna load in the peripheral blood mononuclear cells (pbmcs) of cll patients may influence heterogeneity in the course of the disease. the study included peripheral blood samples from 115 previously untreated patients with cll (5 ... | 2015 | 26460692 |
| production and characterisation of epstein-barr virus helicase-primase complex and its accessory protein bblf2/3. | the helicase-primase complex is part of the lytic dna replication machinery of herpesviruses, but up to now, almost nothing is known about its structure. for epstein-barr virus it consists in the helicase bblf4, the primase bslf1 and the accessory protein bblf2/3. the accessory protein shows only weak sequence homology within the herpesvirus family but may be related to an inactive b-family polymerase. bslf1 belongs to the archaeo-eukaryotic primase family, whereas the helicase bblf4 has been re ... | 2015 | 26292944 |
| peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. | the etiology of multiple sclerosis (ms) involves both genetic and environmental factors. genetically, the strongest link is with hla drb1*1501, but the environmental trigger, probably a virus, remains uncertain. this investigation scans a panel of proteins from encephalitogenic viruses for peptides homologous to the primary autoantigen from myelin basic protein (mbp), then evaluates candidate peptides against a motif required for t cell cross-reactivity and compares viral prevalence patterns to ... | 2015 | 26319106 |
| evasion of affinity-based selection in germinal centers by epstein-barr virus lmp2a. | epstein-barr virus (ebv) infects germinal center (gc) b cells and establishes persistent infection in memory b cells. ebv-infected b cells can cause b-cell malignancies in humans with t- or natural killer-cell deficiency. we now find that ebv-encoded latent membrane protein 2a (lmp2a) mimics b-cell antigen receptor (bcr) signaling in murine gc b cells, causing altered humoral immune responses and autoimmune diseases. investigation of the impact of lmp2a on b-cell differentiation in mice that con ... | 2015 | 26305967 |
| detection of nasopharyngeal carcinoma in morocco (north africa) using a multiplex methylation-specific pcr biomarker assay. | silencing of tumor suppressor genes (tsgs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. the methylation status of such genes can be used for early detection of cancer. we are pursuing this approach in our efforts to develop markers for early detection and follow-up of nasopharyngeal carcinoma (npc). we set out to develop this approach to allow identification of npc from morocco and then also compared with npc samples from differen ... | 2015 | 26300994 |
| rare variants in the spectrum of human herpesvirus 8/epstein-barr virus-copositive lymphoproliferations. | we report 2 rare variants in the spectrum of human herpesvirus 8 (hhv8)/epstein-barr virus (ebv)-copositive lymphoproliferations arising in hiv-seronegative patients, including a large b-cell lymphoma arising in the setting of multicentric castleman disease and a germinotropic lymphoproliferative disorder. in the first case, histology revealed features of multicentric castleman disease and a proliferation of large lymphoid cells forming clusters or arcs or rings replacing the periphery of follic ... | 2015 | 26299509 |
| establishment and characterization of a cd20-positive nk/t-cell lymphoma cell line. | cd20 positive nk/t-cell lymphoma is extremely rare and difficult for clinical treatment. due to the lack of an established cell model for this disease, less is known about its biological characterization and potential therapeutic options. | 2015 | 26299072 |
| ebv epiglottitis: primary supraglottic viral infection in a pediatric immunocompetent host. | in this report we describe a case in which a previously healthy 7 year-old male developed acute epiglottitis secondary to epstein-barr virus (ebv) infection. this patient required fiberoptic intubation and icu stay. we discuss epiglottitis diagnosis and management with ebv as the primary etiologic agent. | 2015 | 26298621 |
| systemic multi-organ involvement in chronic active epstein-barr virus disease. | 2015 | 26315206 | |
| different mechanisms of regulation of the warburg effect in lymphoblastoid and burkitt lymphoma cells. | the warburg effect is one of the hallmarks of cancer and rapidly proliferating cells. it is known that the hypoxia-inducible factor 1-alpha (hif1a) and myc proteins cooperatively regulate expression of the hk2 and pdk1 genes, respectively, in the burkitt lymphoma (bl) cell line p493-6, carrying an inducible myc gene repression system. however, the mechanism of aerobic glycolysis in bl cells has not yet been fully understood. | 2015 | 26312753 |
| host gene expression is regulated by two types of noncoding rnas transcribed from the epstein-barr virus bamhi a rightward transcript region. | in epstein-barr virus-infected epithelial cancers, the alternatively spliced bamhi a rightward transcripts (barts) are the most abundant viral polyadenylated rna. the bart introns form the template for the production of 44 micrornas (mirnas), and the spliced and polyadenylated exons form nuclear non-protein-coding rnas. analysis of host cell transcription by rna-seq during latency in ags cells identified a large number of reproducibly changed genes. genes that were downregulated were enriched fo ... | 2015 | 26311882 |
| the long-lasting love affair between the budding yeast saccharomyces cerevisiae and the epstein-barr virus. | the epstein-barr gammaherpesvirus (ebv) is the first oncogenic virus discovered in human. indeed, ebv has been known for more than 50 years to be tightly associated with certain human cancers. as such, ebv has been the subject of extensive studies aiming at deciphering various aspects of its biological cycle, ranging from the regulation of its genome replication and maintenance to the induction of its lytic cycle, including the mechanisms that allow its immune evasion or that are related to its ... | 2015 | 26311489 |
| non-epstein-barr virus-associated double primary lymphoepithelioma-like carcinoma of the esophagus and stomach: a case report and literature review. | a 55-year-old chinese male was admitted to the hospital for epigastralgia and dysphagia with a two month history, and hematemesis and melena with a two-day history. two lesions were found in the esophagus and stomach by esophago--gastroduodenoscopy and computed tomography. the patient underwent subtotal esophagectomy and gastrectomy, esophagogastric anastomosis above the aortic arch, and thoracic-abdominal two-field lymph node dissection. pathological and immumohistochemical studies showed that ... | 2015 | 26309699 |
| clinical characteristics and laboratory findings in danish children hospitalized with primary epstein-barr virus infection. | epstein-barr virus (ebv) positive infectious mononucleosis (im) is a common disease in adolescents. however, im is often considered a rare disease in early childhood. we aimed to describe the classical presentation of adolescent ebv-associated im compared to ebv infection at younger age. | 2015 | 26308113 |
| epigenetic silencing of tumor suppressor genes during in vitro epstein-barr virus infection. | dna-methylation at cpg islands is one of the prevalent epigenetic alterations regulating gene-expression patterns in mammalian cells. hypo- or hypermethylation-mediated oncogene activation, or tumor suppressor gene (tsg) silencing mechanisms, widely contribute to the development of multiple human cancers. furthermore, oncogenic viruses, including epstein-barr virus (ebv)-associated human cancers, were also shown to be influenced by epigenetic modifications on the viral and cellular genomes in th ... | 2015 | 26324942 |
| early virological and immunological events in epstein-barr virus infection. | epstein-barr virus (ebv) is a γ-herpesvirus which establishes a chronic yet asymptomatic infection in humans. this saliva transmitted virus has a tropism for b lymphocytes, in which it establishes a latent infection, and epithelial cells where the virus replicates to produce infectious particles. although the majority of infections are apparently benign, primary ebv infection can be associated with an acute febrile syndrome, infectious mononucleosis, while infection is also associated with the d ... | 2015 | 26322696 |
| production of thyrotropin receptor antibodies in acute phase of infectious mononucleosis due to epstein-barr virus primary infection: a case report of a child. | various autoantibodies have been reported to be detected during the progression of infectious mononucleosis. we observed a case of infectious mononucleosis due to epstein-barr virus primary infection for 2 months, and noticed the transiently increased titer of thyrotropin receptor autoantibodies detected at the acute phase on the 3rd day after admission. at that time, real-time quantitative pcr also revealed the mrna expressions of an immediate early lytic gene, bzlf1, and a latent gene, ebna2. ... | 2015 | 26322262 |
| possible relations between epstein-barr virus past infection and classic multiple sclerosis in guilan, iran. | multiple sclerosis (ms) is a demyelinating condition affecting the central nervous system. although the cause of this condition is unknown, patients with ms seem to have genetic vulnerability to certain environmental factors such as infection that could trigger this condition. | 2015 | 26322199 |
| angioimmunoblastic t-cell lymphoma presenting with an acute serologic epstein-barr virus profile. | angioimmunoblastic t-cell lymphoma (aitl) is an aggressive peripheral t-cell lymphoma typically characterized by prominent lymphadenopathy and b-symptoms at the time of presentation, polyclonal hypergammaglobulinemia, autoimmune hemolysis and frequent but highly variable involvement of epstein-barr virus (ebv). lymph node biopsy findings typically include effacement of nodal architecture, polymorphic infiltrate, atypical t-cells (usually cd4+/cd10+/pd1+) and prominent proliferations of high endo ... | 2015 | 26331002 |
| integrated analysis of the differential cellular and ebv mirna expression profiles in microdissected nasopharyngeal carcinoma and non-cancerous nasopharyngeal tissues. | nasopharyngeal carcinoma (npc) is commonly diagnosed in southern asia. micrornas (mirnas) are small non-coding rnas that regulate gene expression post-transcriptionally. increasing evidence suggests that the dysregulation of mirnas promotes npc tumorigenesis. epstein-barr virus (ebv) infection and ebv-encoded mirnas are also associated with the development of npc. however, it is unclear how cellular and ebv mirnas jointly regulate target genes and signaling pathways in npc. in the present study, ... | 2015 | 26330189 |
| [oral hairy leukoplakia induced by topical steroids]. | oral hairy leukoplakia (ohl) is an ebv-associated condition of the oral mucosa, which is often painless. it is found predominantly in hiv-positive patients and is considered a clinical indicator of immunosuppression. ohl has rarely been described in hiv-negative patients, being found most often in association with iatrogenic immunosuppression. ohl induced by topical steroids remains extremely rare. | 2015 | 26362131 |
| sequence analysis of epstein-barr virus (ebv) early genes barf1 and bhrf1 in nk/t cell lymphoma from northern china. | nk/t cell lymphoma is an aggressive lymphoma almost always associated with ebv. bamhi-a rightward open reading frame 1 (barf1) and bamhi-h rightward open reading frame 1 (bhrf1) are two ebv early genes, which may be involved in the oncogenicity of ebv. it has been found that v29a strains, a barf1 mutant subtype, showed higher prevalence in npc, which may suggest the association between this variation and nasopharyngeal carcinoma (npc). to characterize the sequence variation patterns of the epste ... | 2015 | 26337172 |
| dissecting the contribution of ebna3c domains important for ebv-induced b-cell growth and proliferation. | epstein-barr virus (ebv) is an oncogenic gammaherpes virus which is linked to pathogenesis of several human lymphatic malignancies. the ebv essential latent antigen ebna3c is critical for efficient conversion of primary human b-lymphocytes to lymphoblastic cell lines and for continued lcl growth. ebna3c, an ebv latent antigen with oncogenic potential can bind and regulate the functions of a wide range of cellular transcription factors. in our current reverse genetics study, we deleted the full l ... | 2015 | 26336822 |
| effect of latent membrane protein 1 expression on overall survival in epstein-barr virus-associated cancers: a literature-based meta-analysis. | latent membrane protein 1 (lmp1) is identified as the main transforming oncoprotein of epstein-barr virus (ebv). lmp1 is frequently expressed in a variety of ebv-associated cancers, including nasopharyngeal carcinoma (npc), non-hodgkin lymphoma (nhl), hodgkin disease (hd), and gastric cancer (gc). however, due to conflicting results, the prognostic value of lmp1 expression on clinical outcomes in ebv-associated cancers remains unclear. we performed a meta-analysis on 32 studies with a total of 3 ... | 2015 | 26336130 |
| inhibition of autophagy in ebv-positive burkitt's lymphoma cells enhances ebv lytic genes expression and replication. | autophagy, an important degradation system involved in maintaining cellular homeostasis, serves also to eliminate pathogens and process their fragments for presentation to the immune system. several viruses have been shown to interact with the host autophagic machinery to suppress or make use of this cellular catabolic pathway to enhance their survival and replication. epstein barr virus (ebv) is a γ-herpes virus associated with a number of malignancies of epithelial and lymphoid origin in which ... | 2015 | 26335716 |
| decreased activation-induced cell death by ebv-transformed b-cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel faslg mutation. | autoimmune lymphoproliferative syndrome (alps) is a primary immunodeficiency characterized by chronic lymphoproliferation, autoimmune manifestations, expansion of double-negative t-cells, and susceptibility to malignancies. most cases of alps are caused by germline or somatic fas mutations. we report the case of an alps patient due to a novel homozygous fasligand gene mutation (alps-faslg). | 2015 | 26334989 |
| epstein-barr virus-driven b cell proliferation with cd4+ t cell expansion: a lymphomatoid granulomatosis-like disease related to hyperinterleukin-10 secretion of remarkably favourable outcome with rituximab. | granulomatous lymphomatosis is an epstein-barr virus (ebv)-driven b cell proliferation associated with an exuberant cd4(+) t cell reaction with usually histopathological pictures of angiocentrism. so far, the characteristics of cd4(+) t cells in granulomatous lymphomatosis and the mechanism leading to their expansion remain poorly explored. we report a 56-year-old female with a past history of cold agglutinin disease, which was successfully treated with 4 weekly infusions of rituximab. she prese ... | 2015 | 26332210 |
| dna methylation patterns in ebv-positive and ebv-negative hodgkin lymphomas. | hodgkin lymphoma (hl) is characterized by the presence of hodgkin and reed-sternberg cells. epstein-barr virus (ebv) infection is thought to play an important role in the development of hl. although epigenetic alterations, such as aberrant dna methylation, are known to contribute to the pathogenesis of various malignancies, little is known about such alterations in hl and their putative relationships with ebv infection. | 2015 | 26350502 |
| autoimmune and atopic disorders and risk of classical hodgkin lymphoma. | results from previous investigations have shown associations between the risk of hodgkin lymphoma (hl) and a history of autoimmune and atopic diseases, but it remains unknown whether these associations apply to all types of hl or only to specific subtypes. we investigated immune diseases and the risk of classical hl in a population-based case-control study that included 585 patients and 3,187 controls recruited from october 1999 through august 2002. we collected information on immune diseases th ... | 2015 | 26346543 |
| ebv-associated cancer and autoimmunity: searching for therapies. | epstein-barr virus (ebv) infects b-, t-, and nk cells and has been associated not only with a wide range of lymphoid malignancies but also with autoimmune diseases such as lupus erythematosus, rheumatoid arthritis and, in particular, multiple sclerosis. hence, effective immunotherapeutic approaches to eradicate ebv infection might overthrow cancer and autoimmunity incidence. however, currently no effective anti-ebv immunotherapy is available. here we use the concept that protein immunogenicity i ... | 2015 | 26344947 |
| yield of diagnostic tests in obese children with an elevated alanine aminotransferase. | nonalcoholic fatty liver disease (nafld) is associated with obesity and affects roughly 10% of children. however, nafld is often diagnosed by exclusion - that is, obese children with an elevated alanine aminotransferase (alt) are screened for other liver diseases in the absence of a biopsy. this testing is nonstandardized, and professional society recommendations differ. this study examines the yield of testing for disorders other than nafld in this patient population. | 2015 | 26341254 |
| epstein-barr virus associated t-cell lymphoproliferative disease misdiagnosed as ulcerative colitis: a case report. | epstein-barr virus (ebv)-associated t-cell lymphoproliferative disease (lpd) is not uncommon in china, but gastrointestinal involvement is very rare. we report on an immunocompetent patient with ebv-associated t-cell lpd of the colon. the 26-year-old man was initially misdiagnosed with ulcerative colitis (uc). a colon biopsy revealed the presence of small to medium-sized lymphoid cells infiltrating the intestinal wall. the neoplastic cells expressed cd3, cd5, and granzyme b, not cd56. ebv-encode ... | 2015 | 26339440 |