Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| global analysis of a plasmid-cured shigella flexneri strain: new insights into the interaction between the chromosome and a virulence plasmid. | shigella flexneri is an important human pathogen that causes dysentery, and remains a significant threat to public health, particularly in developing countries. the virulence of this pathogen is dependent on an acquired virulence plasmid. to investigate the crosstalk between the bacterial chromosome and the exogenous virulence plasmid, a virulence plasmid-cured strain was constructed using plasmid incompatibility. the global patterns of gene expression of this strain compared with the wild-type ... | 2010 | 20000779 |
| characterization of wrss2 and wrss3, new second-generation virg(icsa)-based shigella sonnei vaccine candidates with the potential for reduced reactogenicity. | live, attenuated shigella vaccine candidates, such as shigella sonnei strain wrss1, shigella flexneri 2a strain sc602, and shigella dysenteriae 1 strain wrsd1, are attenuated principally by the loss of the virg(icsa) protein. these candidates have proven to be safe and immunogenic in volunteer trials and in one study, efficacious against shigellosis. one drawback of these candidate vaccines has been the reactogenic symptoms of fever and diarrhea experienced by the volunteers, that increased in a ... | 2010 | 19932216 |
| identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: indolenyl sulfonamide derivatives. | synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide, sulfaguanidine, sulfathiazole, sulfamethoxazole, sulfisoxazole, sulfadiazine and sulfamethazine. these synthesized compounds have been used as potential ligands for complexation with some selective divalent transition metal ions (cobalt, copper, nickel & zinc). structure of the synthesized ligands has been deduced from thei ... | 2010 | 20005022 |
| a bacterial e3 ubiquitin ligase ipah9.8 targets nemo/ikkgamma to dampen the host nf-kappab-mediated inflammatory response. | nf-kappab (nuclear factor kappab) has a pivotal role in many cellular processes, including the inflammatory and immune responses and, therefore, its activation is tightly regulated by the ikk (ikappab kinase) complex and by ikappabalpha degradation. when shigella bacteria multiply within epithelial cells they release peptidoglycans, which are recognized by nod1 and stimulate the nf-kappab pathway, thus leading to a severe inflammatory response. here, we show that ipah9.8, a shigella effector pos ... | 2010 | 20010814 |
| transcriptional profile of the shigella flexneri response to an alkaloid: berberine. | berberine, a natural isoquinoline alkaloid found in many medicinal herbs, has been shown to be active against a variety of microbial infections. to examine the potential effects of berberine on shigella flexneri, a whole-genome dna microarray was constructed and a transcriptome analysis of the cellular responses of s. flexneri when exposed to berberine chloride (bc) was performed. our data revealed that bc upregulated a group of genes involved in dna replication, repair and division. intriguingl ... | 2010 | 20030725 |
| age-related efficacy of shigella o-specific polysaccharide conjugates in 1-4-year-old israeli children. | despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. we reported the safety and immunogenicity of shigella o-specific polysaccharide-protein conjugates in adults and young children and efficacy of shigella sonnei conjugate in young adults. | 2010 | 20056180 |
| the structure of the salmonella typhimurium type iii secretion system needle shows divergence from the flagellar system. | the type iii secretion system (t3ss) is essential for the infectivity of many pathogenic gram-negative bacteria. the t3ss contains proteins that form a channel in the inner and outer bacterial membranes, as well as an extracellular needle that is used for transporting and injecting effector proteins into a host cell. the homology between the t3ss and the bacterial flagellar system has been firmly established, based upon both sequence similarities between respective proteins in the two systems an ... | 2010 | 20060835 |
| osmoregulated periplasmic glucans synthesis gene family of shigella flexneri. | osmoregulated periplasmic glucans (opgs) of food- and water-borne enteropathogen shigella flexneri were characterized. opgs were composed of 100% glucose with 2-linked glucose as the most abundant residue with terminal glucose, 2-linked and 2,6-linked glucose also present in high quantities. most dominant backbone polymer chain length was seven glucose residues. individual genes from the opg gene family comprising of a bicistronic operon opggh, opgb, opgc and opgd were mutagenized to study their ... | 2010 | 20062978 |
| tracking the dynamic interplay between bacterial and host factors during pathogen-induced vacuole rupture in real time. | escape into the host cell cytosol following invasion of mammalian cells is a common strategy used by invasive pathogens. this requires membrane rupture of the vesicular or vacuolar compartment formed around the bacteria after uptake into the host cell. the mechanism of pathogen-induced disassembly of the vacuolar membrane is poorly understood. we established a novel, robust and sensitive fluorescence microscopy method that tracks the precise time point of vacuole rupture upon uptake of gram-nega ... | 2010 | 20070313 |
| the extreme c terminus of shigella flexneri ipab is required for regulation of type iii secretion, needle tip composition, and binding. | type iii secretion systems (t3sss) are widely distributed virulence determinants of gram-negative bacteria. they translocate bacterial proteins into host cells to manipulate them during infection. the shigella t3ss consists of a cytoplasmic bulb, a transmembrane region, and a hollow needle protruding from the bacterial surface. the distal tip of mature, quiescent needles is composed of ipad, which is topped by ipab. physical contact with host cells initiates secretion and leads to assembly of a ... | 2010 | 20086081 |
| th17 cells are the dominant t cell subtype primed by shigella flexneri mediating protective immunity. | the t cell response to shigella, the causative agent of bacillary dysentery, remains poorly understood. using a murine model of infection, we report that shigella flexneri primes predominately il-17a- and il-22-producing th17 cells. shigella-specific th1 cells are only significantly induced on secondary infection, whereas specific th2 and cd8(+) t cells are undetectable. apart from th17 cells that are primed in a mhc class ii- and il-6-dependent, but il12/23p40-independent manner, we identified ... | 2010 | 20089698 |
| a novel antisense rna regulates at transcriptional level the virulence gene icsa of shigella flexneri. | the virulence gene icsa of shigella flexneri encodes an invasion protein crucial for host colonization by pathogenic bacteria. within the intergenic region vira-icsa, we have discovered a new gene that encodes a non-translated antisense rna (named rnag), transcribed in cis on the complementary strand of icsa. in vitro transcription assays show that rnag promotes premature termination of transcription of icsa mrna. transcriptional inhibition is also observed in vivo by monitoring the expression p ... | 2010 | 20129941 |
| innate immune detection of the type iii secretion apparatus through the nlrc4 inflammasome. | the mammalian innate immune system uses toll-like receptors (tlrs) and nod-lrrs (nlrs) to detect microbial components during infection. often these molecules work in concert; for example, the tlrs can stimulate the production of the proforms of the cytokines il-1beta and il-18, whereas certain nlrs trigger their subsequent proteolytic processing via caspase 1. gram-negative bacteria use type iii secretion systems (t3ss) to deliver virulence factors to the cytosol of host cells, where they modula ... | 2010 | 20133635 |
| crystal structure of the dna-recognition component of the bacterial virus sf6 genome-packaging machine. | in herpesviruses and many bacterial viruses, genome-packaging is a precisely mediated process fulfilled by a virally encoded molecular machine called terminase that consists of two protein components: a dna-recognition component that defines the specificity for packaged dna, and a catalytic component that provides energy for the packaging reaction by hydrolyzing atp. the terminase docks onto the portal protein complex embedded in a single vertex of a preformed viral protein shell called procapsi ... | 2010 | 20133842 |
| a repulsive electrostatic mechanism for protein export through the type iii secretion apparatus. | many gram-negative bacteria initiate infections by injecting effector proteins into host cells through the type iii secretion apparatus, which is comprised of a basal body, a needle, and a tip. the needle channel is formed by the assembly of a single needle protein. to explore the export mechanisms of mxih needle protein through the needle of shigella flexneri, an essential step during needle assembly, we have performed steered molecular dynamics simulations in implicit solvent. the trajectories ... | 2010 | 20141759 |
| [endodontic approach to injured teeth]. | 2010 | 2897345 | |
| mutagenesis and chemical cross-linking suggest that wzz dimer stability and oligomerization affect lipopolysaccharide o-antigen modal chain length control. | in shigella flexneri, the polysaccharide copolymerase (pcp) protein wzz(sf) confers a modal length of 10 to 17 repeat units (rus) to the o-antigen (oag) component of lipopolysaccharide (lps). pcps form oligomeric structures believed to be related to their function. to identify functionally important regions within wzz(sf), random in-frame linker mutagenesis was used to create mutants with 5-amino-acid insertions (termed wzz(i) proteins), and dna sequencing was used to locate the insertions. anal ... | 2010 | 20453100 |
| carbon metabolism of intracellular bacterial pathogens and possible links to virulence. | new technologies such as high-throughput methods and 13c-isotopologue-profiling analysis are beginning to provide us with insight into the in vivo metabolism of microorganisms, especially in the host cell compartments that are colonized by intracellular bacterial pathogens. in this review, we discuss the recent progress made in determining the major carbon sources and metabolic pathways used by model intracellular bacterial pathogens that replicate either in the cytosol or in vacuoles of infecte ... | 2010 | 20453875 |
| acid stress response in enteropathogenic gammaproteobacteria: an aptitude for survival. | enteric bacteria such as escherichia coli have acquired a wide array of acid stress response systems to counteract the extreme acidity encountered when invading the host's digestive or urinary tracts. these acid stress response systems are both enzyme and chaperone based. the 3 main enzyme-based acid resistance pathways are glutamate-, arginine-, and lysine-decarboxylase pathways. they are under a complex regulatory network allowing the bacteria to fine tune its response to the external environm ... | 2010 | 20453931 |
| enterobacteriaceae associated with eggs of podocnemis expansa and podocnemis unifilis (testudines:chelonia) in nonpolluted sites of national park of araguaia plains, brazil. | fertile eggs of podocnemis expansa and podocnemis unifilis were investigated for the presence of enterobacteria, as these two endangered species have the potential for conservation measures that include egg transfer. knowledge of normal microflora associated with turtles and turtle eggs would help effectively manage the transfer of these eggs among institutions. thirty eggs of each species were collected, aseptically transferred, cracked inside plastic bags containing tetrathionate broth, and sp ... | 2010 | 21370647 |
| ribonucleases and bacterial virulence. | bacterial stress responses provide them the opportunity to survive hostile environments, proliferate and potentially cause diseases in humans and animals. the way in which pathogenic bacteria interact with host immune cells triggers a complicated series of events that include rapid genetic re-programming in response to the various host conditions encountered. viewed in this light, the bacterial host-cell induced stress response (hcisr) is similar to any other well-characterized environmental str ... | 2010 | 21375713 |
| [biological functions and time--the loose coupling mechanism of molecular machines]. | 2010 | 2934765 | |
| knowledge about suicide as a function of experience. | 2010 | 2928057 | |
| the mmpi and psychological factors in chronic low back pain: a review. | the minnesota multiphasic personality inventory (mmpi) is widely used in the psychological assessment of patients with chronic low back pain (lbp). patients' profiles have been used in a number of ways: in attempts to discriminate between cases; as predictors of both medical treatment and pain management program outcomes; and in attempts to assess degree of disability. studies reviewed here indicate that the concept of psychological etiology of chronic lbp, despite widespread use, has failed to ... | 2010 | 2950363 |
| immunosuppressive effects of blood transfusion in anaesthesia and surgery. | the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ... | 2010 | 3067486 |
| immunosuppressive effects of blood transfusion in anaesthesia and surgery. | the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ... | 2010 | 3067486 |
| role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury. | to determine the mechanism responsible for the enhanced susceptibility of endothelial cells to oxidant injury in the absence of glucose, we induced endothelial cell injury with oxygen radicals in the presence of various oxygen radical scavengers and measured endothelial cell levels of glutathione after oxidant injury in the presence and absence of glucose. endothelial cells were damaged with toxic oxygen radicals generated by phorbol myristate acetate (pma)-activated polymorphonuclear leukocytes ... | 2010 | 3091744 |
| an antitumor polypeptide antibiotic neocarzinostatin: the mode of apo-protein--chromophore interaction. | the mode of neocarzinostatin-chromophore (ncs-chr)-apo-neocarzinostatin (apo-ncs) interaction in neocarzinostatin (ncs) complex has been described. the ncs-chr release from the ncs complex in the presence of various reagents, which destroy the high-order structure of the protein under various ph conditions, was examined. we found that (i) sodium dodecylsulfate, nonidet p 40, 8 m urea, and 2-propanol did release ncs-chr from ncs, (ii) no ncs-chr release is detected below ph 7, but it is enhanced ... | 2010 | 2967272 |
| effect of isotretinoin on survival of patients with myelodysplastic syndrome. | 2010 | 2884408 | |
| nmr contrast agents for proton imaging. | 2010 | 2832350 | |
| [personal experience in the diagnosis and therapy of boerhaave's syndrome]. | at the surgical clinic of the faculty hospital in hradec králové during the last 20 years 32 patients with perforation of the oesophagus were treated. of these five had a spontaneous rupture of the oesophagus--boerhaave's syndrome. the authors describe their own experience with the diagnosis of this syndrome. they emphasize the importance of early diagnosis which determines the type of surgical treatment, makes a more radical operation possible, reduces the percentage of complications and thus a ... | 2010 | 2799554 |
| aids out of the closet. | 2010 | 2830567 | |
| [non-enzymatic protein glycosylation and its clinico-biological significance]. | 2010 | 2798209 | |
| ternary representation of trivariate data. | a new fast trivariate display technique based on the ratio of three measured variables and of relative cell number, obtained from flow cytometric measurements, is described. | 2010 | 2917477 |
| misunderstanding possible in scope of work. | 2010 | 2922197 | |
| [use of prostacyclin in patients with ischemic stroke. a double-blind method ii]. | thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. the treatment was started 24 to 72 hours after the onset of stroke. prostacyclin sodium (wellcome, u.k. or chinoin, hpr) or its solvent (glycine buffer) were administered intravenously once daily during 2 weeks in 6-hour infusions. prostacyclin was infused at rates of 2.5-5.0 ng/kg/min. statistically significant improvement appeared from the second day on in t ... | 2010 | 3067105 |
| [use of prostacyclin in patients with ischemic stroke. a double-blind method ii]. | thirty patients with acute ischaemic stroke were allocated randomly into a group treated with prostacyclin and a group receiving placebo. the treatment was started 24 to 72 hours after the onset of stroke. prostacyclin sodium (wellcome, u.k. or chinoin, hpr) or its solvent (glycine buffer) were administered intravenously once daily during 2 weeks in 6-hour infusions. prostacyclin was infused at rates of 2.5-5.0 ng/kg/min. statistically significant improvement appeared from the second day on in t ... | 2010 | 3067105 |
| bspmii and acciii are an isoschizomer pair which differ in their sensitivity to cytosine methylation. | 2010 | 2841649 | |
| distribution and morphology of somatostatin cells. | 2010 | 2863943 | |
| functional significance of the kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. | blood coagulation can be initiated when factor vii or viia, a plasma protease, binds to its essential cofactor, tissue factor (tf), and proteolytically activates factors ix and x, triggering a cascade of events which eventually leads to the formation of thrombin and a fibrin clot. plasma contains a lipoprotein-associated coagulation inhibitor (laci) which inhibits activated factor x (xa) directly and, in a xa-dependent way, inhibits vii(a)/tf activity, presumably by forming a quaternary xa/laci/ ... | 2010 | 2927510 |
| components of depression in attempted suicides. | 2010 | 4748966 | |
| rapid detection of cutaneous herpes simplex virus infection with the polymerase chain reaction. | a simple and specific method for detecting herpes simplex virus infection in routinely processed paraffin-embedded biopsy specimens is described. dna is extracted from paraffin blocks, and subjected to dna amplification with the polymerase chain reaction. after 40 rounds, an amplified band can be detected after agarose gel electrophoresis and ethidium bromide staining. this band is specific for herpes simplex virus, because tissues infected with related viruses do not give this amplified band. w ... | 2010 | 2918243 |
| tardive dyskinesia. | 2010 | 2892565 | |
| safety and efficacy of estrace (micronized 17 beta-estradiol). | 2010 | 2906339 | |
| [atypical variant of cushing's syndrome]. | 2010 | 2897495 | |
| [biochemical aspect in cardiac ischemia--ischemic changes and reperfusion injury]. | 2010 | 2838873 | |
| carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. occurrence of complex-type sugar chains with the gal beta 1----3glcnac beta 1----3gal beta 1----4glcnac beta 1----outer chains. | nonspecific cross-reacting antigen-2 (nca-2) is a glycoprotein purified from meconium as a closely correlated entity with carcinoembryonic antigen (cea). as in the case of cea, only asparagine-linked sugar chains are included in nca-2. in order to elucidate the structural characteristics of the sugar chains of nca-2, they were quantitatively released from the polypeptide backbone by hydrazinolysis and reduced with nab3h4 after n-acetylation. the radioactive oligosaccharides were fractionated by ... | 2010 | 2808357 |
| epidemiological aspects of tardive dyskinesia. | although there continues to be some debate as to the extent to which neuroleptic drug treatment is either necessary or sufficient to produce abnormal involuntary movements in various psychiatric populations, the consensus at present is that neuroleptics do play a major role in producing, precipitating or evoking abnormal involuntary movements. no doubt a variety of other factors play a critical role in predisposing particular individuals to the development of the condition. numerous prevalence s ... | 2010 | 3063513 |
| [tecto-thalamo-telencephalic visual system of the brain in 13-day-old chick embryos]. | light and electron microscopic studies have been made of the nervous tissue in three parts of the tecto-thalamo-telencephalic visual system--i.e. tectum opticum, nucleus rotundus of thalamus and ectostriatum of telencephalon--of 13-day chick embryos. neuroblasts and neurones at various stages of differentiation were described together with various types of synaptic and nonsynaptic intercellular contacts in the neuropil of these brain structures. heterochronous maturation of these parts of the vi ... | 2010 | 3051806 |
| [pathogenetic aspects of schönlein-henoch disease]. | 2010 | 2940752 | |
| multiple gamma radiation sterilization of polyester fibres. | gamma radiation with a dose of 2.5 mrad has been found to be suitable to sterilize polyethylene terephthalate (pet) bulk materials intended for biomedical applications. the radiation stability of pet bulk materials and fibre may not however be taken as identical due to the changes in the polymer structure during the processing of bulk materials for fibre. the chemical changes occurring in pet fibres during single and multiple (prolonged) sterilization in air were investigated. it was found that ... | 2010 | 2975186 |
| hyperresponsiveness to water immersion in sodium retaining cirrhotics: the role of atrial natriuretic factor. | cirrhotics do not respond uniformly to head-out water immersion (hwi). some cirrhotics have an exaggerated natriuresis while others are unresponsive. we studied the humoral and urinary responses to hwi in 5 cirrhotics and compared this to 5 normals on the same 20 mm sodium intake. these cirrhotics had a documented tendency to salt and water retention but had minimal or no evidence of significant ascites. plasma levels of atrial natriuretic factor (anf) increased during immersion in both groups. ... | 2010 | 2976331 |
| arm exercise testing for coronary artery disease in patients with peripheral vascular disease. | we evaluated 74 peripheral vascular disease (pvd) patients (54 men, age 61 +/- 7 years and 17 women, age 63 +/- 7 years) for potential coronary heart disease (cad) using an arm exercise test (aet) protocol. all patients performed upright two-arm cranking using discontinuous stages of 2 minutes of exercise separated by 2 minutes of rest. exercise intensity was increased by +100 or 200 kpm (kilopond meters) with each stage. ecg was monitored continuously and blood pressure and 12-lead ecg tracings ... | 2010 | 2894261 |
| multiple small papular seborrheic keratosis. | 2010 | 2976363 | |
| leads from the mmwr. measles prevention: supplementary statement. | 2010 | 2913378 | |
| [various factors affecting the level of detection of schizophrenics]. | having studied the population of the schizophrenic patients registered at the psychoneurological dispensary of samarkand (n = 678) the authors have revealed that the identification of patients depends on both age/sex structure of the general population and the educational level. it has been found that underdetection of schizophrenics in samarkand is mainly accounted for by favourable cases of schizophrenia in particular in the following social groups: in young people under 19 years; in people wi ... | 2010 | 2950691 |
| initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. iii. sensory inputs to tr1 and tr2. | in papers i and ii of this series, we described two pairs of interneurons, tr1 and tr2, in the leech subesophageal ganglion which can trigger swimming activity in the isolated central nervous system (cns). in this paper, we describe sensory inputs to these trigger neurons from previously identified mechanosensory neurons. we found that: weak mechanical stimulation (stroking) of a body wall flap attached to a segmental ganglion in an otherwise isolated cns excites the contralateral tr1 slightly. ... | 2010 | 3023604 |
| internal medicine in the national resident matching program 1978-1989. | 2010 | 2930105 | |
| [hemorrhagic fever with renal syndrome. a survey of zoonosis]. | 2010 | 2876539 | |
| domestic chlorine poisoning. | 2010 | 2863507 | |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| immunogenetics of graves' ophthalmopathy. | we have performed an immunogenetic analysis of 53 patients with severe graves' ophthalmopathy, 51 patients with graves' disease but little or no clinically apparent eye disease, and 90 controls. the distribution of restriction fragment length polymorphisms was analysed in the three groups, using probes for the hla-dq alpha and dr beta regions, the t-cell receptor c alpha, v alpha, c beta and j gamma genes and the immunoglobulin gene switch regions, s alpha and s mu. there was no abnormal distrib ... | 2010 | 2908181 |
| investigation of the substrate binding and phosphate transfer in adenylate kinase by molecular mechanics. | molecular mechanics calculations of adenylate kinase (adk) complexed with atp, amp, and mg2+ have been carried out with three different model-built geometries. the lowest energy structure is that inferred from the x-ray structure, but such a geometry is not as consistent with the inference of an noe contact between his36 and the atp c2-h proton as the model of the second lowest energy. we have used the latter structure as a basis for modeling the reaction amp + atp----2adp in the presence of mg2 ... | 2010 | 2840275 |
| issues affecting the future of dentistry. | 2010 | 2797616 | |
| the student health center: a unique clinical experience for nursing leadership students. | 2010 | 3035135 | |
| technique for measurement of one-dimensional instantaneous ablation velocity. | an oscillating mirror scanned a he-ne laser beam along the length of a thin rod while the rod was ablated by an argon laser beam. the shadow of the scanning beam on an image plane provides a picture of the instantaneous ablation velocity of the rod. this configuration provides a unique method for investigating one-dimensional ablation. | 2010 | 2976448 |
| dental implications of pharmacological management of the alzheimer's patient. | 2010 | 2975266 | |
| button wires in the treatment of mandibular fractures. | button wiring has been used as an alternative to eyelet wiring in the department of oral and dental surgery of birmingham general hospital since 1977. this clinical update reviews 65 patients with mandibular fractures in which button wires were utilised in their treatment. | 2010 | 3091722 |
| [surgical therapy of prenatally detected abdominal abnormalities]. | 2010 | 3042547 | |
| [surgical therapy of prenatally detected abdominal abnormalities]. | 2010 | 3042547 | |
| [behavior of iron complexes with nucleotides in erythrocytes in the course of blood preservation]. | 2010 | 4671501 | |
| [flexion-distraction injuries of the thoracolumbar spine with complete pancreatic rupture. description of a case]. | a case is reported of an unstable fracture dislocation of the thoracolumbar vertebral column combined with complete rupture of the pancreas. this combination of injuries is rarely encountered but is dangerous in severely injured patients. rapid and decisive operative treatment of both injuries should be performed, whereby adequate treatment of the pancreatic rupture has the highest priority. | 2010 | 2916133 |
| dysplastic nevi. markers for increased risk for melanoma. | a total of 452 white patients, classified into four dysplastic nevi groups, were followed prospectively by repetitive, complete cutaneous examinations using total-body photographs taken on entry into the study. sixteen patients (3.5%) developed 18 newly diagnosed malignant melanomas (mm) during an average follow-up period of 27 months. twelve of the 18 mm were in situ, and all of the six primary invasive mm diagnosed prospectively in this follow-up were less than 0.89 mm in breslow thickness, im ... | 2010 | 2910446 |
| [nutrition in the etiology of breast cancer. results of a survey in austria]. | 2010 | 2934651 | |
| dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons. | glutamate is able to stimulate inositol phosphate (ip) formation in striatal neurons in primary culture, mainly via an excitatory amino acid receptor of the quisqualate subtype. in the present study we show that carbachol (carb)-(a cholinergic agonist), but not neurotensin or norepinephrine-induced ip production could be reduced by 40% when measured in the presence of glu. the inhibition of the carb response by glu was dose dependent and reproduced by n-methyl-d-aspartate (nmda). quisqualate eli ... | 2010 | 2890092 |
| rural health care in the developing world. | 2010 | 2857377 | |
| a variant of mucolipidosis. ii. clinical, biochemical and pathological investigations. | we present in this paper a patient with a clinically intermediate form of mucolipidosis (ml). lysosomal hydrolase activity in fibroblasts was normal and levels of these enzymes in culture media were not elevated. there was a striking elevation of several hydrolases in serum and a deficiency (15% of normal) of n-acetyl-glucosamine phosphotransferase in fibroblasts. atypical electron microscopic findings were also observed. there was no evidence of increased synthesis, slower turnover, unbalanced ... | 2010 | 2839346 |
| the use of dc electric fields to promote regeneration in the mammalian nervous system. | 2010 | 3064792 | |
| the use of dc electric fields to promote regeneration in the mammalian nervous system. | 2010 | 3064792 | |
| morphological characterization of the somatostatin-immunoreactive dendritic skin cells in urticaria pigmentosa patients by computerized image analysis. | by means of computerized image analysis, the somatostatin-immunoreactive epidermal and dermal dendritic cells of certain urticaria pigmentosa patients were characterized. the evidence obtained supported the concept that the epidermal cells correspond to the langerhans cells. | 2009 | 2860719 |
| morphological characterization of the somatostatin-immunoreactive dendritic skin cells in urticaria pigmentosa patients by computerized image analysis. | by means of computerized image analysis, the somatostatin-immunoreactive epidermal and dermal dendritic cells of certain urticaria pigmentosa patients were characterized. the evidence obtained supported the concept that the epidermal cells correspond to the langerhans cells. | 2009 | 2860719 |
| the functional role of the muscle spindle's primary end organs. | 2009 | 4229845 | |
| [osteolytic foci: cancer or not?]. | 2009 | 2797229 | |
| gallbladder perforation seen on hepatobiliary imaging following morphine sulfate injection. | a case of gallbladder perforation imaged during morphine-augmented cholescintigraphy is presented. tc-99m disida imaging dramatically demonstrated the bile leak. whether morphine sulfate contributed to the perforation of the gallbladder is debatable. | 2009 | 2791419 |
| memory deficit caused by compressed air equivalent to 36 meters of seawater. | twenty-four students from a diving school undertook a hyperbaric chamber dive to a pressure equal to 36 m of seawater. tests of cognitive function and manual dexterity, performed in the chamber during the 35-min bottom time and before, or after, the dive included immediate and delayed free recall of words presented as 7 lists of 15 each, recognition of previously presented words, number identification, and a forceps pickup of ball bearings. delayed free recall and immediate free recall (primacy ... | 2009 | 2737993 |
| [computed tomography in the diagnosis of isolated bone metastases and its influence in therapy planning]. | in a collective of 70 patients with bone metastases the importance of ct for detection and extension diagnosis is shown. in 53% ct proved the scintigraphic and/or roentgenologic suspicion. in 30% ct gave more information than scintigraphy and plain radiography, but without any influence in the treatment. in 17% only ct gave such important information, that the planned treatment must be changed. the results led to the conclusion, that ct can be important for the optimization of radiological treat ... | 2009 | 2748800 |
| who are borderline patients? | "borderline" is a term used with increasing frequency to describe certain difficult patients. it refers to a heterogeneous population of patients who tend to get involved in impaired doctor-patient relationships. different areas of psychiatry have their own, often conflicting definitions of these disorders. early trauma, neglect and genetic diatheses to axis i disorders commonly occur in the backgrounds of these patients. most have a combination of factors. with the multiple different definition ... | 2009 | 2688086 |
| morphogen gradients and the control of body pattern in insect embryos. | the basic body plan of insects is set up in response to determinants initially localized at the anterior and posterior poles of the egg. early in development, these determinants give rise to a series of morphogen gradients which in turn trigger a cascade of molecular signals determining the body pattern. this signalling process is outlined and recent experiments testing the roles of these gradient systems in determining anterior and posterior pattern are described. the results of these experimen ... | 2009 | 2673685 |
| letter: comments on scabies. | 2009 | 4852728 | |
| promising drug combination for sickle cell anemia. | 2009 | 2716139 | |
| 45 years ago--the pioneer health centre, peckham. | 2009 | 2681768 | |
| erythropoietin and chronic renal failure. | 2009 | 2771635 | |
| decreased cardiac toxicity of doxorubicin administered by continuous intravenous infusion in combination chemotherapy for metastatic breast carcinoma. | two hundred and seventy-four consecutive patients with measurable metastatic breast cancer, without prior exposure to cytotoxic agents were treated with tamoxifen, 5-fluorouracil, doxorubicin, and cyclophosphamide (fac). the initial 133 patients received doxorubicin by bolus iv administration and for the next group of 141 patients doxorubicin was administered via a central venous catheter over a 48-hour (79 patients) or 96-hour (62 patients) continuous infusion schedule. patients treated with bo ... | 2009 | 2910423 |
| [hepatic mesenchymal hamartoma]. | a case is presented of a 10-year-old female twin with a cystic liver mass that debuted as a painless epigastric mass. the lesion was excised by hepatectomy of segments ii and iii, confirming in the review of the cavity the presence of a common mesentery with cecocolonic malposition. the postoperative course was normal and clinical and echographic study of her twin sister disclosed no anomalies. the anatomopathologic study of the lesion revealed a tumor of difficult filiation that presented featu ... | 2009 | 2652212 |
| training inspiratory resistance in duchenne dystrophy using adapted computer games. | computer games were modified to encourage respiratory effort by two groups of patients with duchenne muscular dystrophy. one group trained during the first six months of the study, the other during the second six months. inspiratory effort was increased by their having to breathe through a mask to both start and continue the games. pulmonary function tests were done at the beginning of the trial and six, 12 and 18 months later, when forced vital capacity, respiratory muscle endurance and strengt ... | 2009 | 2806735 |
| training inspiratory resistance in duchenne dystrophy using adapted computer games. | computer games were modified to encourage respiratory effort by two groups of patients with duchenne muscular dystrophy. one group trained during the first six months of the study, the other during the second six months. inspiratory effort was increased by their having to breathe through a mask to both start and continue the games. pulmonary function tests were done at the beginning of the trial and six, 12 and 18 months later, when forced vital capacity, respiratory muscle endurance and strengt ... | 2009 | 2806735 |
| spontaneous expulsion of a large submucosal colonic lipoma. | 2009 | 2810300 | |
| "a few bad apples?". | 2009 | 2812134 | |
| "a few bad apples?". | 2009 | 2812134 | |
| neuroprostheses in the management of incontinence in children. | 2009 | 2788362 |