Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| monoamine oxidase inhibitory modulators in rat heart cytosol: evidence for induction by thyroid hormone. | inhibitory modulators of monoamine oxidase (mao) were found in rat heart 105,000 x g supernatant. the modulators inhibited mao activity present in the outer mitochondrial membrane. the inhibition was noncompetitive when using membrane-associated mao as enzyme source. the modulators did not, however, inhibit the enzyme activity in the soluble fraction prepared from outer mitochondrial membranes. mao inhibitory modulator concentration in rat heart cytosol was increased by the administration of t4 ... | 1982 | 7140633 |
| the effect of some iodine-containing radiocontrast agents on iodothyronine secretion from the perfused canine thyroid. | the effects of the iodine-containing radiocontrast agents ipodate, iopanoic acid, and iothalamate on the secretion of t4, t3, and rt3 were studied using perfused canine thyroid lobes. the experiments were performed as paired comparisons, with one thyroid lobe acting as a control. at 10(-5) m, the two agents used for cholecystography (ipodate and iopanoic acid) inhibited the tsh-stimulated secretion of t3 [ipodate, 69 +/- 8% of control (p less than 0.05); mean +/- se; n =4] and rt2 [iopanoic acid ... | 1982 | 7140639 |
| comparison of thyroid hormone binding to heptic nuclei of the rat and a teleost (oncorhynchus kisutch). | a modified t3 binding assay was used with coho salmon liver nuclei. purified nuclei were incubated with [125i]t3 (or [125i]t4), nonradioactive thyroid hormone, or thyroid hormone analog. bound hormone was separated from hormone by use of polyethylene glycol. salmon liver nuclei specifically bound t3 with a high affinity [ka = 1.031 +/- 0.174 x 10(9) m-1 (mean +/- se); n = 12] which was 50% of the affinity measured with rat liver nuclei using the same assay. salmon nuclear t3-binding capacity was ... | 1982 | 7140642 |
| the effect of experimental hyperthyroidism and hypothyroidism on 5'-monodeiodination of 3,3',5'-triiodothyronine and 3',5'-diiodothyronine by rat liver and kidney. | to study the effect of alterations in thyroid status on 5'-monodeiodinase activity, conversions of rt3 to 3,3'-diiodothyronine and 3',5'-diiodothyronine (3',5'-t2) to 3'-monoiodothyronine were examined in vitro. rats were injected either with t4 (10 micrograms/100 g bw, ip, daily for 12 days) to make them thyrotoxic or thyroidectomized to render them hypothyroid, and liver and kidney homogenates were prepared. liver homogenates from hyperthyroid animals demonstrated a 2-fold increase in 5'-monod ... | 1982 | 7140645 |
| planned preoperative radiation therapy for advanced laryngeal carcinoma. | one hundred ten patients with predominantly advanced laryngeal carcinoma were treated in the period 1969-1978 with planned preoperative radiation therapy followed by surgery. site distribution was: 63 supraglottic, 26 glottic, 15 transglottic and 6 subglottic. there were 4 stage ii patients, 66 stage iii and 40 stage iv. preoperative radiation therapy consisted of telecobalt irradiation to a total dose of 25 gy given to a target volume encompassing the larynx and regional neck nodes, given in 5 ... | 1982 | 7141928 |
| osseous proliferation on the cranial and caudal borders of the dorsal spinous processes of t4-t6, suggestive of osteitis. | 1982 | 7141957 | |
| serum myoglobin in primary hypothyroidism and effect of l-thyroxine therapy. | serum myoglobin (mb) concentrations have been measured by radioimmunoassay in normal subjects, in hypothyroid patients examined 20 days after withdrawal of thyroid hormone therapy ("short-term" hypothyroidism), and in untreated hypothyroids ("long-term" hypothyroidism). in "short-term" hypothyroids, serum mb levels were significantly higher (p less than 0.01) than those observed in normal controls, although only a minority or patients showed elevated mb levels. in "long-term" hypothyroids, serum ... | 1982 | 7143091 |
| spontaneous remission of t4-thyrotoxicosis caused by multiple autonomous thyroid nodules. | 1982 | 7143099 | |
| unusual presentation of head and neck neoplasm. | we have a 67-year-old caucasian male presenting with a (t4, n1b, mo) stage iii squamous cell carcinoma of the larynx. he subsequently underwent a total laryngectomy and right radical neck dissection. it was only determined by the pathology report that the cervical nodes in the neck specimen obtained the associated disease, hodgkin's (mixed cellular lymphoma), rather than the expected well differentiated squamous cell carcinoma found in the larynx. metastatic work-up was unrevealing. reviewing th ... | 1982 | 7144395 |
| effect of cold and glucoprivation of tsh and t4 release in normothermic and hyperthermic rats. | 1982 | 7146056 | |
| effect of theophylline on thyroid status in the rat. | the effect of administration of theophylline, thyroxine (t4), or a combination of the two, for 14 days on body weight, food intake, serum concentrations of t4 and 3,5,3'-triiodothyronine (t3), and on the rate of 5'-monodieodination of t4 to t3 by hepatic and renal homogenates was evaluated. administration of t4 (25 micrograms/kg b.w./day) increased the serum concentration of t4 and t4 5'-deiodinase activity. administration of theophylline (191 mg/kg b.w./day) increased the serum concentration of ... | 1982 | 7146082 |
| [liver glycogen, blood glucose, somatotropic hormone, and hypophyseal thyrotropin in neonatal rats treated with cortisol and in malnourished ones]. | a population of rats treated with a single dose of cortisol on their first day of life and a population of rats underfed since day sixteen of gestation until sacrificed have been studied. body, brain and liver glycogen content have been measured at eight, twelve and twenty-two days of life and compared to controls of the same age. pituitary growth hormone and thyrotrophin content have also been measured in the same population of animals and at the same stages of life. results are compared to tho ... | 1982 | 7146580 |
| consequences of the chronic cutaneous application of iodinated antiseptics on the thyroid function in the guinea-pig. | the effect of the chronic cutaneous application of iodine-containing substances on the thyroid function was studied in the guinea-pig. six iodinated products were daily applied at the rate of 2 g/kg/day for 90 days. we find a quasi-abolition in the thyroid 131i-uptake (reflecting the transcutaneous absorption of free iodine) and an important transient thyroidal hyperproduction during the first month. then, this primary hyperthyroidism induces a strong pituitary negative feed-back so that the lev ... | 1982 | 7148202 |
| low serum 3, 5, 3'-triiodothyronine (t3) and raised 3, 3', 5'-triidothyronine (reverse t3 or rt3) in diabetes mellitus: normalization on improvement in hyperglycemia. | in several pathophysiologic states, i.e., cirrhosis of liver, protein calorie malnutrition, starvation, carbohydrate deprivation, etc., thyroid hormone metabolism is reported to be altered with a decrease in serum t3 and a reciprocal increase in tr3. uncontrolled diabetes mellitus is a similar state in which glucose does not enter the cells causing cellular starvation and hyperglycemia ensues. therefore, serum t4, t3, rt3, t3-resin uptake, tsh, and glucose were determined after an overnight fast ... | 1982 | 7148329 |
| characteristics of rt3 5'-monodeiodination in rat brain: comparison with t4 and t3 5-monodeiodinations. | the present study revealed the existence and some characteristics of rt3 5'-deiodinase in rat brain by measuring the production of 3,3'-t2 from rt3 by radioimmunoassay. the conversion of rt3 to 3,3'-t2 was dependent on the duration of the incubation, tissue amount, temperature and ph (the optimal ph was 8.0), suggesting its enzymatic nature. apparent km was estimated to be 0.16 microm and the vmax was 139.3 fmol/mg protein/min. the converting activity was dependent on the concentration of dithio ... | 1982 | 7148334 |
| effect of long-term iodide refeeding on the synthesis and secretion of t3, t4 and tsh in severe iodine deficient rats. | 1982 | 7148335 | |
| [serum bupivacaine concentrations in patients with continuous peridural anesthesia administered by thoracic catheter]. | continuous infusion of a 0.2% solution of bupivacaine via a peridural catheter in a rate of 0.2 ml/kg x h is sufficient to make a patient pain-free for any time required following upper abdominal or abdomino-thoracic surgery. the zone of analgesia extends segmentally from t4 to t12/l1 so that the patient can be mobilized. if necessary an insufficient blockade can be completed by bolus injection of 10 to 15 ml of 0.2% solution. using this technique over a period of four days after surgery, serum ... | 1982 | 7149216 |
| purification of t4 rna ligase by dextran blue-sepharose 4b affinity chromatography. | 1982 | 7149245 | |
| [hypothyroidism acquired in childhood. apropos of case]. | authors present a patient who, when three years old, was studied because of weight and psychic retardation. physical data were as following: weight, 9.9 kg (less than 93); height, 90 cm (p 10-25); head circumference, 43,5 cm (less than p3); bone age, 2 3/12 years, and the thyroid function, normal. i131 uptake, 43.5% after 24 h. tbi: t3 index, 1.07; t4, 7.7 gamma %. ft4 index, 7.2. thyroid scan, normal. diagnosis was: intrauterine dwarfism and iron-deficiency anemia. at 6 6/12 years old, he had m ... | 1982 | 7149478 |
| microwave sterilization of plastic tissue culture vessels for reuse. | a simple protocol has been developed for recycling plastic tissue culture vessels. the killing properties of microwaves were used to decontaminate plastic tissue culture vessels for reuse. nine bacterial cultures, four gram-negative and five gram-positive genera, including two bacillus species, were used to artificially contaminate tissue culture vessels. the microwaves produced by a "home-type" microwave oven (2.45 ghz) were able to decontaminate the vessels with a 3-min exposure. the same expo ... | 1982 | 7149721 |
| phosphorothioate substrates for t4 rna ligase. | stereochemical details of the t4 rna ligase reaction mechanism have been delineated by examining the reactivity of phosphorothioate analogues in the adenosine 5'-triphosphate (atp) dependent and atp-independent rna ligase reactions. only the sp isomer of the diastereomeric dinucleoside thiopyrophosphate, app(s)i, was active as an activated donor substrate in the atp-independent rna ligase reaction. the thiophosphodiester linkage in the ligation product, apapap(s)i, that is formed by the reaction ... | 1982 | 7150532 |
| effect of l-thyroxine on metabolism in japanese quails (cotournix cotournix japonica)--ii. activity of got and gpt in liver, ldh and icdh in heart and kidney after multiple injections of l-thyroxine. | 1. quails hatched from eggs incubated at physiological temperature (37.5 degrees c--normal quails) and elevated (39.3 degrees c--warm quails) were injected with l-thyroxine (t4) at the dose of 600 micrograms/kg of body weight, every 48 hr for 17 days. 2. twenty-four hours after the last injection activity of aspartate aminotransferase (got), alanine aminotransferase (gpt) was determined in liver homogenates and lactate dehydrogenase and isocitrate dehydrogenase in homogenates of heart and kidney ... | 1982 | 7151409 |
| properties of hexosaminidases in cell-free extracts of rainbow trout livers and effects of thyroid hormones. | 1. the kinetic and physical properties of hexosaminidase (ec 3.2.1.30) activity were studied in liver extracts of juvenile rainbow trout. 2. differential centrifugation studies failed to unequivocally demonstrate the sub-cellular localization of hexosaminidase, but indicated that the hexosaminidase activity was associated with the mitochondrial and lysosomal fractions. 3. cell-free, triton x-100 liver extracts indicated a ph optimum and activation energies comparable to those of mammals, but for ... | 1982 | 7151413 |
| [therapeutic effect and change of serum tsh, t3 and t4 levels after treatment of primary hypothyroidism with different dosages of desiccated thyroid tablets]. | 1982 | 7151567 | |
| preferential secretion of triiodothyronine in man. | the directly measured secretion rates of thyroxine (t4), 3,5,3'-triiodothyronine (t3), and 3,3',5'-triiodothyronine (rt3) were compared to the tissue concentrations of these hormones and to the distribution of follicular iodoproteins in 15 patients submitted to thyroid or parathyroid surgery. the t4/t3 and rt3/t3 ratios were higher for thyroid tissue than for the secretion rates, indicating a preferential secretion of t3. the concentrations of t4 and t3 were higher in the 27s iodoprotein fractio ... | 1982 | 7152470 |
| propranolol induced changes in plasma catecholamine, corticosterone, t4, t3 and prolactin levels in the pigeon. | concentrations of plasma noradrenaline, adrenaline, corticosterone, thyroxine (t4), triiodothyronine (t3) and prolactin were measured in pigeons at 22 degrees c after intravenous injection of propranolol (1 mg/kg). an increase in catecholamines occurred in 5 or 15 min. t4, t3 and prolactin increased within 30 and 60 min after injection, however, after correction for the differences in plasma protein content, only the concentration of prolactin was significantly above the control values. it is co ... | 1982 | 7152474 |
| effects of antiepileptic drugs on hgh, tsh, and thyroid hormone concentrations during pregnancy. | the effects of antiepileptic drugs on thyrotropin (tsh), thyroid hormone, and growth hormone (gh) concentrations in sera of 16 pregnant women with epilepsy were studied. the drugs markedly depressed thyroxine (t4) concentration in maternal and umbilical cord sera, and partly depressed tsh in maternal and umbilical artery sera and gh in umbilical artery sera, but not triiodothyronine (t3) or reverse t3 (r-t3) concentration. the effect of antiepileptic drugs on t4 concentration in maternal serum w ... | 1982 | 7152712 |
| serial blood t4 and tsh determinations in low birth weight infants. influence of gestational age, birth weight and neonatal pathology on thyroid function. | serial blood t4 and tsh determinations were performed on a total number of 352 low birth weight (lbw) infants: 210 healthy newborns and 142 infants affected by respiratory distress syndrome (rds), sepsis, hyperbilirubinaemia, hypocalcemia, or hypoglycemia. the healthy infants have been divided into three groups in relation to gestational age (less than or equal to 33 wk, 34-36 wk, greater than or equal to 37 wk). statistical evaluation among groups shows that reduced t4 concentration in lbw infa ... | 1982 | 7153056 |
| temperature and adrenocortical responses in rhesus monkeys exposed to microwaves. | to determine if the endocrine response to microwave exposure was similar in a primate to that reported for other animals, rectal temperature and plasma levels of cortisol, thyroxine (t4), and growth hormone (gh) were measured in rhesus monkeys exposed to 1.29 ghz microwave radiation. exposures were carried out under far-field conditions with the monkey restrained in a chair. incident power densities of 0, 20, 28, and 38 mw/cm2 were used, with corresponding specific absorption rates of 0, 2.1, 3. ... | 1982 | 7153151 |
| management of myxedema coma: report on three successfully treated cases with nasogastric or intravenous administration of triiodothyronine. | three consecutive cases of myxedema coma treated successfully with either nasogastric or intravenous route of administration of i-triiodothyronine, followed by oral thyroxine, are described. all were hypothermic, had biochemical evidence of advanced hypothyroidism (t4 less than 1.0 micrograms/dl, t3 less than 20 ng/dl and tsh greater than 150 microu/ml), severe hypoxemia, respiratory acidosis, hypercarbia and temporary depression of respiratory center responsiveness. in only one patient it was f ... | 1982 | 7153477 |
| gene 67, a new, essential bacteriophage t4 head gene codes for a prehead core component, pip. i. genetic mapping and dna sequence. | 1982 | 7154087 | |
| gene 67, a new, essential bacteriophage t4 head gene codes for a prehead core component, pip. ii. the construction in vitro of unconditionally lethal mutants and their maintenance. | 1982 | 7154088 | |
| [fundamental and clinical study of the amerlex free t4 ria kit and the in vitro effect of added hemoglobin on free t4 values]. | 1982 | 7154422 | |
| effects of cortisol administration on development of the thyroid and adrenal axes in rats. | intraperitoneal (ip) injections of cortisol were administered to neonatal male rats on postnatal days 1 to 4. plasma triiodothyronine (t3), thyroxine (t4) and corticosteroids were determined on days 5, 10, 13, 16, 20, 30 and 60 of age, and all animals were weighed weekly. neonatal cortisol treatment resulted in depressed body weight gain and transient depression in plasma t4. these results indicate that while body weight is significantly affected by cortisol treatment ontogenic patterns of plasm ... | 1982 | 7154853 |
| thyroid function and continuous ambulatory peritoneal dialysis. | thyroid function was evaluated in 16 patients with end-stage renal failure, 8 treated by maintenance haemodialysis (hd) and 8 by continuous ambulatory peritoneal dialysis (capd), and compared with 8 healthy subjects. serum total thyroxine (t4) and triiodothyronine (t3) concentrations were low in both groups (p less than 0.01) with t3 significantly lower in the capd than the hd group (p less than 0.01). serum-free thyroxine (ft4) concentrations were low in capd patients with respect to normal (p ... | 1982 | 7155243 |
| methodological background of the amersham amerlex free thyroxine ria. | this contribution describes the essential rules underlying a valid estimation of ft4 and compares the way in which various methods deviate from ideal behaviour. the amerlex ft4 ria test has been validated by several approaches. a practical demonstration of the ability of various methods to correct for differences in t4-binding protein concentration has been made by independent studies in a uk hospital on euthyroid non-pregnant, euthyroid contraceptive and euthyroid pregnant women. the amersham k ... | 1982 | 7155903 |
| [a radiochemically stable, t4-analogous tracer of high specific activity suitable for the measurement of ft4]. | 1982 | 7155904 | |
| [comparison of ft4 and total t4 estimates as single parameters in the evaluation of thyroid state]. | 1982 | 7155905 | |
| thyroxine, triiodothyronine and iodide in different breeds of newborn calves. | plasma thyroxine (t4), triiodothyronine (t3) and iodide levels were measured from birth until 30 days of age in 17 holstein x friesian (hf), 7 salers and 7 charolais calves born at term. the response of plasma t4 and t3 levels to bovine thyrotropin (tsh) injection was also compared in two groups of 9 hf calves 3hrs and 21 days, respectively, after birth. in the hf calves, plasma t4 and t3 levels increased from birth to 6 hrs (when the rectal temperature of these calves decreased slightly), then ... | 1982 | 7156485 |
| plasma iodothyronine levels in lambs during the perinatal period: influence of thyrotropin injection. | plasma thyroxine (t4) and triiodothyronine (t3) levels were measured in 7 pregnant ewes and their 9 chronically cannulated foetuses during the last 37 days of gestation and the first 5 days after parturition. the highest plasma t4 and t3 levels were measured in lambs during the hours following parturition. in 7 chronically cannulated 139-day old foetal lambs, the intravenous injection of ovine thyrotropin (otsh; 7 mu per foetus) induced a significantly more intense increase in plasma t4 and t3 l ... | 1982 | 7156497 |
| effects of thoracic dorsal rhizotomy or vagotomy on inspiratory muscle activity at various levels of chemical drive. | the relationship between relative peak activity (moving average emg) of the diaphragm (adi) and of the cranial (2nd and 3rd) external intercostal or parasternal muscles (aic) was assessed during rebreathing in animals before and after bilateral thoracic (t1-t4) dorsal rhizotomy (tdr) and/or bilateral vagotomy (vgt). the relationship had the form aic=a adib under all conditions. in intact rabbits and cats mean values for b were 1.48 and 1.79, respectively, a being unity by definition. neither tdr ... | 1982 | 7156533 |
| iodothyronine and thyrotropin concentrations after iodoamide administration for angiographic studies. | in order to study the effect of iodoamide (a contrast medium widely used for urographic and arteriographic studies) on thyroid function, seventeen subjects were studied before and after arteriographic examinations employing this contrast compound. serum concentrations of t4, t3, rt3 and tsh were not modified during the observation period by the administration of iodoamide. this finding is in contrast with the observation that iopanoic acid and ipodate, used for cholecystographic examinations, ca ... | 1982 | 7156708 |
| thyroid hormone resistance in a 35-year old man with recurrent goitre. | without firm diagnosis a 16-year old boy was submitted to subtotal thyroidectomy because of a diffuse goitre and emotional instability. no definite improvement was obtained in the alleged toxic symptoms and the goitre recurred. during subsequent years increased serum concentrations of thyroid hormones have repeatedly been observed in the absence of clear-cut hyperthyroid symptoms. judging from clinical examination and a normal basal metabolic rate the patient, now 35 years old, was euthyroid at ... | 1982 | 7156868 |
| [endemic goiter in austria. is iodine deficiency the primary cause of goiter?]. | in spite of government-regulated iodide admixture to table salt, the incidence of goiter is still high in austria. iodine excretion and thyroid function were therefore investigated in 80 patients suffering from ordinary goiter in whom thyroid size and resulting symptoms had increased lately. 25 euthyroid non-goitrous subjects served as controls. 48% of the goitrous patients investigated presented with iodine excretion of less than 70 micrograms/24 h, suggesting an insufficient iodine supply. thy ... | 1982 | 7156942 |
| a longitudinal study of serum tsh, and total and free iodothyronines during normal pregnancy. | serum t4, t3, rt3, free t4, free t3 and tsh were measured during and after normal pregnancy in 20 women. special methodological precautions were taken to avoid interference of other hormones and protein alterations in the assays. serum t4 and t3 were steadily increasing during the last part of the 1st trimester, and remained high and nearly stable during the 2nd and 3rd trimester of the gestation period. the high levels were approximately 1.5 times the values measured 10 weeks post-partum. serum ... | 1982 | 7158229 |
| modifications of the pituitary-thyroid axis induced by hypobaric hypoxia. | the effects of simulated altitude induced by a decompression chamber upon the blood levels of thyrotropin (tsh), thyroxine (t4) and triiodothyronine (t3), measured by radioimmunoassay, were studied in male wistar rats. when blood was extracted during the first 15 minutes after the rats were removed from the chamber and analysed, it was found that tsh levels decreased at 380 mmhg during 24 hours and sometimes at 440 mmhg during 24 hours, but this did not happen when the exposure lasted a week. li ... | 1982 | 7158375 |
| [effect of surgery on the level of total and free thyroid hormones, reverse t3 and tsh]. | changes in total and free thyroid hormones, reverse triiodothyronine (rt3) and tsh were followed in 64 patients undergoing surgery and divided into three groups according to nature of surgery. group i patients underwent extraperitoneal surgery, group ii mild and group iii heavy intraperitoneal surgery. a significant fall in total and free triiodothyronine (t3), a rise in rt3, free thyroxine (ft4) and in tsh were noted in each group after surgery, while total t4 levels remained unchanged. there w ... | 1982 | 7159046 |
| stress by immobilization, with food and water deprivation, causes changes in plasma concentration of triiodothyronine, thyroxine and corticosterone in poultry. | measurements were sought for assessment of stress during investigations of welfare in intensively housed poultry. immobilization was used as a stressor in experiments involving 64 cockerels of various ages. two parameters were found to be related to acute stress: plasma triiodothyronine (t3) concentration, which fell markedly, and plasma corticosterone concentration, which rose considerably, in all birds during severe stress. concurrently, plasma thyroxine (t4) concentration also fell in most, b ... | 1982 | 7159295 |
| interaction of ageing, photoperiod and melatonin on plasma thyroid hormones and cholesterol levels in female syrian hamsters (mesocricetus auratus). | plasma levels of thyroxine (t4), triiodothyronine (t3) and growth hormone (gh) as well as the free t4 and free t3 index (ft4i, ft3i) in 20-month-old female syrian hamsters kept under long daily photoperiod [light:dark (ld) cycles of 14:10] were significantly depressed compared to the values of 2-month-old animals kept under the same photoperiodic conditions. cholesterol levels in old females were significantly elevated compared to those in young animals. in a subsequent experiment, young (4 mont ... | 1982 | 7160621 |
| thyroidal status in uremia - effects of hemodialysis and capd. | thyroid function was explored in 27 capd patients and 25 hd patients. dialysis was associated with low t3 and t4 levels, increased rt3 concentrations, normal t4 : t3 and reduced t4 : rt3 ratios, normal ft3 and thyroglobulin concentrations. tsh levels increased during dialysis but still fell within normal limits. the data rule out a condition of primary hypothyroidism and point out to increased thyroidal dismission associated with the block t4-t3 in peripheral cells. also the increased ft4 levels ... | 1982 | 7160930 |
| growth and sexual maturation in ewes: the role of photoperiod, diet and temperature on growth rate and the control of prolactin, thyroxine and luteinizing hormone secretion. | the relationship of photoperiod, temperature and diet on growth rate and serum concentrations of thyroxine (t4), prolactin (prl) and luteinizing hormone (lh) were studied in ewe lambs from 9 to 32 wk of age. lambs reared on a diet supplying 1.78 kcal/g net energy had higher (p less than .025) serum t4 concentrations and greater average daily gain (adg) than lambs fed a lower energy ration (1.5 kcal/g). long artificial photoperiod of 16 h of light neither improved adg nor altered t4 concentration ... | 1982 | 7161216 |
| processing of bacteriophage t4 primary transcripts with ribonuclease iii. | 1982 | 7161796 | |
| physiology of turkey embryos during pipping and hatching. iv. thyroid function in embryos from selected hens. | embryos from turkey hens selected for high and low hatchability were blood sampled at 24, 25, 26, 27, and 28 days of incubation. the plasma was recovered and assayed for thyroxine (t4) and triiodothyronine (t3) to observe differences in plasma t3 and t4 concentrations relative to reduced hatchability. plasma t3 did not differ significantly between the high and low hatchability groups, but plasma t4 concentrations were significantly greater during pipping at 26 and 27 days of incubation in the hi ... | 1982 | 7163123 |
| pharmacokinetics of resorcinol in the rat. | pharmacokinetic data on resorcinol were obtained from studies in the rat. the drug, administered subcutaneously in an aqueous solution, rapidly cleared plasma vir urine and did not accumulate in tissues. in the urine, the major metabolite of resorcinol was the glucuronide. repeated dosing for 30 days with maximum tolerated daily doses of 100 mg/kg did not alter pharmacokinetic parameters, nor did it cause overt toxic signs or adverse reactions. the animals' body weight, blood values, levels of s ... | 1982 | 7163635 |
| changes of triiodothyronine and thyroxine in patients with thyrocardiac disease and their relationship to systolic time intervals. | the relationship between the ejection time from the left ventricle (lvet), the pre-ejection period (pep) of the left ventricle, the q-kd interval, the course of the achilles tendon reflex (atr) and the thyroxine (t4) and triiodothyronine (t3) serum level in 184 patients with different grades of thyroid function was investigated. some of these patients suffered from cardiac affection caused by thyrotoxicosis or ischemic heart disease. the significant inverse correlations between the t3 level and ... | 1982 | 7166163 |
| the nature of inhibition of thyroid monoamine oxidase by thyroxine in rat thyroid. | the effect of thyroxine on rat thyroid monoamine oxidase (mao) activity in vivo and in vitro was studied in order to evaluate the nature of the inhibition of the enzyme. monoamine oxidase activity was measured in rat thyroid homogenate. thyroxine (200 micrograms kg-1) or triiodothyronine (40 micrograms kg-1) injected in vivo inhibited the activity of monoamine oxidase (mao) significantly (p less than 0.05). thyroxine (t4), 10 micrograms added to the incubation mixture during 20 min also inhibite ... | 1982 | 7166166 |
| structural changes during the transformation of bacteriophage t4 polyheads. ii. evidence that a conformational change in the major capsid protein precedes the expansion. | 1982 | 7166758 | |
| a correlative quantitative study comparing the nerve fibers in the cervical sympathetic trunk and the locus of the somata from which they originate in the rat. | correlative quantitative analyses were performed on the rat comparing the number of fibers in the cervical sympathetic trunk (cst) and the horseradish peroxidase (hrp)-labeled neurons in the superior cervical sympathetic ganglion (scg), stellate ganglion, as well as in the spinal cord. the total number of nerve fibers in the left cst was 4180 +/- 169 (mean +/- s.e.m.) among which 92 +/- 3 (mean +/- s.e.m.) were myelinated. the diameter of unmyelinated fibers was 0.68 +/- 0.22 (mean +/- s.d.) mic ... | 1982 | 7169501 |
| [measurement of free t4 in the blood by radioimmunoassay]. | 1982 | 7170356 | |
| squamous cell carcinoma of bladder. a review of 114 patients. | a retrospective review of 114 cases of squamous cell carcinoma of bladder presenting in glasgow between 1964 and 1978 is described with emphasis on treatment and survival. ninety-seven patients (92.4%) were found to have invasive tumours (t2-t4) at diagnosis. metastatic disease was confirmed in only 10 patients (8.8%). only 23.8% of patients were alive one year after diagnosis, the overall 5-year survival rate being 1.9%. the 5-year survival rates for patients with t2 and t3 disease following ra ... | 1982 | 7171960 |
| a case report on disequilibrium hypercalcemia in hyperthyroidism. comparison of calcium metabolism with other patients with hyperthyroidism. | the patient, a 30-year-old woman, was admitted to itoh hospital in february, 1979 for hyperthyroidism. she had a history of pyelonephritis and recurrent urinary tract infection. laboratory data on admission revealed overt hyperthyroidism (t3: 405 ng/dl, t4: 22.5 micrograms/dl and t3u: 57.--%), severe hypercalcemia of 12.6 mg/dl and hypercalciuria. the psp excretion and gfr were both decreased. serum c-pth was nondetectable. as the thyroid function improved, there was a gradual decrease and later ... | 1982 | 7173116 |
| influence of photoperiod and temperature on weight gain, food consumption, fat pads and thyroxine in male golden hamsters. | weight gain in control and pinealectomized male golden hamsters is enhanced by exposure to short photoperiods (ld 8:16). modest temperature reductions (10 degrees c) enhanced weight gain also, especially in the blinded animals. in the absence of both eyes and the pineal gland, neither temperature nor photoperiod had much or any effect on weight gain. food consumption on the other hand increased only as a consequence of lowered temperature. efficiency of food utilization was maximal at higher (22 ... | 1982 | 7173701 |
| reciprocal effects of an acute load of thyroxine or triiodothyronine on their peripheral metabolism and deiodination in the cold-acclimated rat. | wistar rats acclimated to cold received iv 25 micrograms t 4/100 g bw, 21 micrograms t 3/100 g bw or 2.5 micrograms t 3/100 g bw, to observe the changes induced in the peripheral metabolism of 125i-t4 and 125i-t3 relative to cold-adapted untreated animals. each animal was injected with a tracer dose of either labelled hormone in addition to the t4 or t3 load, and placed in metabolic cages for 24 hour collection of urine and feces. sequential heparinized blood samples were obtained by cardiac pun ... | 1982 | 7175104 |
| reciprocal changes in serum 3, 3', 5'-tri-iodothyronine concentration and the peripheral thyroxine inner ring monodeiodination during food restriction in the young pig. | utilizing the difference in ph optima between two distinct enzyme systems responsible for the thyroxine (t4) inner and outer ring monodeiodination, and a specific radioimmunoassay for iodothyronines, the net t4 conversion to 3, 3', 5'-tri-iodothyronine (rt3) and 3, 5', 3'-tri-iodothyronine (t3) in growing pigs kept under various food restrictions was determined in vitro. it has been found that fasting lowers deiodination of t4 to t3 by liver and kidney homogenates. the conversion of t4 to rt3 wa ... | 1982 | 7175423 |
| immunological aspects associated with suppression of hormone levels in rats infected with plerocercoids of spirometra mansonoides (cestoda). | the effect of the plerocercoid larvae of spirometra mansonoides on hormone levels and the immune system of intact and hypophysectomized (hx) rats was studied. intact rats exhibited a decrease in serum growth hormone (gh) and thyroxine (t4) concentrations and a suppression of the humoral immune response 2 wk postinfection. at 4 and 9 wk postinfection, hormone concentrations and the humoral immune response returned to normal levels in the rats. when rats were infected with plerocercoids and then r ... | 1982 | 7175621 |
| the lipogenic effect of the growth factor produced by plerocercoids of the tapeworm, spirometra mansonoides, is not the result of hypothyroidism. | plerocercoid larvae of the tapeworm, spirometra mansonoides produce a growth hormone-like factor that stimulates body growth of a variety of normal and hormone-deficient animals. plerocercoid infection (15 per hamster) stimulated an increase in body weight, and markedly suppressed pituitary weight and growth hormone (gh) concentrations of serum and pituitaries of syrian hamsters. the suppression of serum gh persisted for at least 4 mo after the initiation of infection. the presence of plerocerco ... | 1982 | 7175622 |
| crystallization of a tryptic core of the single-stranded dna binding protein of bacteriophage t4. | 1982 | 7175942 | |
| neurogenic pulmonary edema associated with autonomic dysreflexia. | neurogenic pulmonary edema is associated with a variety of central nervous system injuries and results from a massive centrally mediated sympathetic discharge. another syndrome characterized by sympathetic overactivity is autonomic dysreflexia, which occurs in patients with spinal cord injury above t4 to t6. we describe a patient with a cervical spinal cord injury who had intense, prolonged autonomic dysreflexia following external sphincterotomy, which culminated in pulmonary edema. traction on ... | 1982 | 7176031 |
| [high doses of map in the treatment of prostatic carcinoma in stage t3-t4. four-year study]. | 1982 | 7177068 | |
| lithium treatment and thyroid function. a survey of 237 patients in long-term lithium treatment. | in a cross-sectional study of 237 patients treated with lithium for more than six months, 10 patients had serum thyroid stimulating hormone (tsh) values above 35 mu/l and concomitantly low triiodothyronine (t3) and abnormally low serum thyroxine (t4). eight patients had tsh values of 10.0-34.9 mu/l, while t3 and t4 were within or close to the normal ranges. most of the patients had tsh values of 0.9-9.9 mu/l and normal or close to normal t3 and t4 values. three male patients had tsh below 0.9 mu ... | 1982 | 7178229 |
| interaction of selenium and lead on several aspects of thyroid function in pekin ducklings. | lead shot recovered at necropsy 2 and 3 weeks after being dropped down the throats of pekin ducklings caused significant increases in thyroid gland weight and 24-hr thyroid uptake of 125i while serum pb125i levels were maintained at or above control values. supplementation of lead shot with 1 ppm selenium in drinking water reduced these increases. selenium in the drinking water incurred no increase in thyroid gland weight at 2 weeks but some goitrogenicity at 3 weeks and significant reductions i ... | 1982 | 7178658 |
| the possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people. | healthy subjects aged 70-90 and 20-40 years were investigated for the level of reverse triiodothyronine (rt3). the mean level in 57 old subjects was higher and the triiodothyronine (t3) level lower than in 30 young persons. no negative correlation was observed. a serum t3 elevation caused by liothyronine administration (5-15 micrograms/day for two weeks) was not followed by a change of the mean rt3 level in 12 old subjects. after a single intramuscular thyrotropin (tsh) injection, the rt3 elevat ... | 1982 | 7180357 |
| [acute suppurative thyroiditis]. | authors present a case of acute suppurative thyroiditis gland being normal before in a 5 8/12 year old. plasma tsh, t3 and t4 remained within normal ranges. an alpha haemolytic streptococcus was isolated from suppuration and thyroglossal duct remnant was not identified. surgical treatment was quickly followed by recovery. some considerations about clinical picture, pathogenesis, etiology, prognosis and treatment are made. usefulness of thyroid scan is emphasized. | 1982 | 7183218 |
| [preclinical and manifest hypothyroidism following thyroid gland operation]. | 62 patients who were strumectomized on account of carcinoma of the thyroid gland, hyperthyroidism and thyroiditis underwent an after-examination on an average 6 years after operation. in preclinical hypothyroidism which cannot be differed from euthyroidism on the basis of the thyroid hormone concentrations, or only by means of the trh-tolerance test, an increased tsh-response after trh-tolerance and a t3-preference in comparison to t4 were observed. in manifest hypothyroidism the compensatory me ... | 1982 | 7184228 |
| [renal handling of 3,5,3'-triiodothyronine (t3) in the dog studied by stopflow analysis]. | in order to investigate the renal handling of 3,5,3'-triiodothyronine (t3), we studied the clearance of t3 (ct3) in dogs and the site of tubular secretion and reabsorption of t3 in dog kidney using the stopflow technique (malvin et al.). four female dogs, weighing between 12.2 and 17.8 kg, were used for ct3 measurement. fourteen anesthetized dogs, weighing between 7.8 and 17.5 kg, were used for the stopflow study. after the catheter was inserted into the left ureter, 15% mannitol solution and is ... | 1982 | 7185575 |
| [monodeiodination of thyroxine to 3,3',5'-triiodothyronine in the human placenta]. | we investigated the characteristics of the monodeiodination of thyroxine to t3 and rt3 in human placentas which were obtained at normal delivery. the placentas were homogenized in a cold sucrose tris-hcl buffer, ph 7.5. the microsomal fraction was incubated at 37 degrees c in air for 1 hr with 2 micrograms of t4 in the presence of 50mm dtt. the t3 and rt3 generated in the reaction mixture were extracted into cold ethanol and measured by ria. among the usal subcellular fractions of the placental ... | 1982 | 7185576 |
| human t-cell malignancies: correlative clinical, histopathologic, immunologic, and cytochemical analysis of 23 cases. | twenty-three t-cell neoplasms were investigated for their reactivity with the okt monoclonal antibodies and expression of certain cytochemical markers. fourteen neoplasms with diverse histopathologic features, t-cell chronic lymphocytic leukemia, mycosis fungoides, the sézary syndrome, t-immunoblastic sarcoma, and a pleomorphic large-cell lymphoma, expressed the t helper cell phenotype, okt3+t4+. nine other neoplasms displayed marked inter- and intra- tumor heterogeneity. seven of these cases, l ... | 1982 | 6978074 |
| phenotypic heterogeneity of human t-cell malignancies: demonstration by monoclonal antibodies and cytochemical markers. | the present study sought to delineate the phenotypic heterogeneity of the human t-cell malignancies. twenty t-cell neoplasms were investigated for reactivity with the okt hybridoma monoclonal antibodies and expression of acid alpha-naphthyl acetate esterase (anae), beta-glucuronidase (bg), and acid phosphatase (ap) activity. twelve cases (mycosis fungoides, sezary syndrome, cutaneous t-cell lymphoma, chronic lymphocytic leukemia) were okt3't4', ie, expressed the phenotype commonly associated wit ... | 1982 | 6979245 |
| [study of t-lymphocyte subpopulations through monoclonal antibodies]. | we studied the lymphocyte subpopulations t4+ and t8+ through monoclonal antibodies (mcab). the end of our study was focused in understanding the differences between the values mentioned by the literature and, consequently, determining our range of normality. thus, we determined the subpopulations t4 and t8 using the antibodies okt4 ind and okt8 sup, which define respectively the subpopulations t helper and t suppressor. such determinations have been fulfilled whether on the total lymphocytes or ... | 1982 | 6979343 |
| identification by monoclonal antibodies of t-cell subpopulations activated by 12-o-tetradecanoylphorbol-13-acetate (tpa). | two major t-cell subpopulations obtained from human peripheral blood were studied their capacity to be activated by the tumor promoting agent, 12-o-tetradecanoylphorbol-13-acetate (tpa). the subpopulations were identified and separated from each other by their reactivity either to the monoclonal antibody, okt4 or okt8, followed by complement-dependent lysis. the fraction enriched in t8+ cells showed approximately a 1.2-2.0-fold greater proliferative response to tpa (20 ng/ml) than did the t4+ ce ... | 1982 | 6980189 |
| preliminary observations on the absorption of biliary iodothyronines from the intestine in vivo in rats. | from a drained bile duct of the rats injected i. v. with various doses of l-thyroxine (50 to 200 microgram per animal) bile was obtained which was then injected to various parts of intestine in recipient rats. the recipient animals were anesthetized with pentobarbiturate and their bile duct as well as femoral artery and vein were cannulated with polyethylene tubings. the level of thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) in plasma and biliary excretion of th ... | 1982 | 6980784 |
| insulin binding and response to insulin of adipocytes from thyroxine-treated rats. | insulin binding to isolated fat cells from rats rendered hyperthyroid by daily injections of t4 (1 mg/kg) for 5 days was approximately doubled. the scatchard curves reflected a large increase in receptor number, as well as an elevation in affinity of the high affinity binding sites. the response to insulin of the fat cells, however, was not increased accordingly: glucose incorporation into lipid in the presence of insulin did not differ significantly from that observed in the control group, wher ... | 1982 | 7035151 |
| [replication characteristics of colicinogenic plasmid colk in escherichia coli cells]. | a fraction of plasmid dna from k and x colicins producing escherichia coli k235 cells was studied. cells of this strain are shown to contain four types of plasmids with molecular weights of 21.6.10(6), 38.8.10(6) daltons. transformation of e. coli c600 by a total plasmid dna yielded clones containing a single plasmid - colicinogenic k factor (colk, a mol wt 4.4.10(6)). colk dna is present in cells in a large number of copies, replicates in the presence of chloramphenicol, requires dna polymerase ... | 1982 | 7035291 |
| in situ immunologic characterization of cellular constituents in lymph nodes and spleens involved by hodgkin's disease. | the cellular constituents in lymph nodes and spleens of patients with hodgkin's disease were studied with a series of monoclonal antibodies directed against human thymocyte, peripheral t-cell, and la antigens. utilizing both an immunoperoxidase technique on frozen tissue sections and indirect immunofluorescence on cell suspensions, wer found that a majority of lymphocytes were t cells, since they stained with anti-t1 and anti-t3 antibodies, which react with all peripheral t cells. in addition, m ... | 1982 | 7034810 |
| follow-up results from a randomized trial for t3 and t4 breast cancer patients: previous bcg immunotherapy improves response to chemotherapy in the relapse patient. | following locoregional treatment, patients were randomized into three groups: the first groups received no complementary treatment; the second group received adjuvant chemotherapy (vincristine, cyclophosphamide, and 5-fluorouracil once a month for 12 months); and the third group was treated by immunotherapy (150 mg bcg once a week for 1 year). sixty-two of the 82 patients studied were menopausal. no significant difference was observed between the three groups. all patients were followed-up for a ... | 1982 | 7036278 |
| defective thyroid hormone action in fibroblasts cultured from subjects with the syndrome of resistance to thyroid hormones. | two preadolescent girls and their mother with the syndrome of central and peripheral resistance to thyroid hormones are reported. the sisters had goiters, high radioiodine uptakes, high plasma levels of thyroid hormones, normal tsh levels, and brisk increases in tsh after trh administration, but had no clinical evidence of thyrotoxicosis. the mother, who had undergone partial thyroidectomy and radioiodine therapy, presented with mild hypothyroid symptoms, normal thyroid hormone levels, and a hig ... | 1982 | 7037814 |
| effect of endotoxin fever on plasma clearance of thyroxine and tri-iodothyronine: concise communication. | endotoxin-induced fever in rabbits causes a rapid decrease in serum t3, a reciprocal rise of 3,3',5'-tri-iodothyronine (rt3), and a less marked reduction in t4 with a rebound at 24 hr. to answer the question whether the alteration in hormone levels was the result of a decrease in t3 or t4 production and release or of an increase in t3 and t4 metabolism, we measured the disappearance of [125i]t4 and [125i]t3 during endotoxin-induced fever and externally applied heat. results showed no significant ... | 1982 | 7038056 |
| the role of rho in bacteriophage t4 development. i. control of growth and polarity. | 1982 | 7039086 | |
| the role of rho in bacteriophage t4 development. ii. mot-dependent (middle mode) rna synthesis. | 1982 | 7039088 | |
| caffeine inhibits dna polymerase i from escherichia coli: studies in vitro. | caffeine inhibits the activity of dna polymerase i (e. coli) and its proteolytic large fragment in in vitro dna replication system. dna polymerase from micrococcus luteus is also equally inhibited by caffeine. the extent of inhibition was more with the activated adenovirus, t4 and calf thymus dna than with synthetic dna template-primers. results obtained from time-course studies indicated that caffeine inhibition reached maximum by 30 min of incubation. enzyme kinetic studies showed that inhibit ... | 1982 | 7039855 |
| roles of cell surface components of escherichia coli k-12 in bacteriophage t4 infection: interaction of tail core with phospholipids. | the cell surface of escherichia coli k-12, reconstituted from the ompc protein, lipopolysaccharide, and the peptidoglycan layer, was active as a receptor for phage t4, resulting in the contraction of the tail sheath and the penetration of the core through the cell surface (furukawa et al., j. bacteriol. 140:1071--1080, 1979). in the present work the process of dna ejection from the contracted t4 phage particle was studied. contracted phage particles were adsorbed to phospholipid liposomes by the ... | 1982 | 7040345 |
| in vitro system for middle t4 rna. i. studies with escherichia coli rna polymerase. | we describe crude in vitro systems from t4-infected cells which reflect in vivo t4 regulation. lysates from cells which had been infected in the presence of chloramphenicol manifest the same polarity of rna synthesis as did the infected cells. next, we describe a complementation system between lysates which have no rna synthetic capacity and purified rna polymerase; in this system, delayed early rna synthesis in vitro depends on the presence of an active mot gene product. mot activity controls m ... | 1982 | 7040377 |
| in vitro system for middle t4 rna. ii. studies with t4-modified rna polymerase. | 1982 | 7040378 | |
| structural characteristics of the short-tail fibers of t4 bacteriophage. | the characteristics of pure preparations of short-tail fibers of bacteriophage t4 have been studied in the optical and electron microscope. three main structures were observed: 1) spheres of 8.1 nm diameter; 2) fibers 43 nm long and 3.8 nm thick; and 3) fibers 54 nm long and 3.2 nm thick. both types of fibers exhibited a regular beaded appearance. the 43-nm fibers were the most abundant structure. during the process of purification of the short-tail fibers, the formation of aggregates was observ ... | 1982 | 7040434 |
| enzymatic replacement of the anticodon of yeast phenylalanine transfer ribonucleic acid. | an efficient procedure for the replacement of the anticodon and the adjacent hypermodified nucleotide (residues 34-37) of yeast trnaphe with any desired oligoribonucleotide sequence has been developed. the four residues are removed by chemical cleavage at y-37 and partial ribonuclease a digestion at u-33. an oligonucleotide is inserted in three steps by using t4 rna ligase and t4 polynucleotide kinase. when different oligonucleotides are inserted, both the size of the loop and the sequence of nu ... | 1982 | 7041969 |
| the role of pre-operative adjuvant therapy in the management of borderline operability rectal cancer. | one hundred and forty-three patients with potentially operable primary rectal cancer (of stage t2, t3 and t4), were allocated to one of three regimens of therapy, i.e. surgery only (s), pre-operative radiotherapy followed by surgery (r), or pre-operative radiotherapy combined with daily intravenous fluorouracil during the first 4 days of irradiation followed by surgery (c). the adjuvant therapy was well tolerated. it had no adverse effects on surgical procedures or morbidity. there was improveme ... | 1982 | 7042179 |
| effects of thyroid hormone on the insulin receptor in rat liver membranes. | although many studies have investigated the complex interrelationships between thyroid hormone levels and insulin-glucose secretion and action, there is at present a lack of information concerning the effects of various thyroid hormone levels on insulin receptors. in the present study, rat liver membranes were prepared from control, hyperthyroid [10 micrograms l-t4 (t4)/100 g bw for 14 days], and hypothyroid rats and the binding characteristics of [125i]iodoinsulin to these membranes were studie ... | 1982 | 7042320 |
| comparison of peripheral thyroid hormone metabolism in normal rats and in rats receiving prolonged glucagon infusion. | an elevated plasma glucagon concentration and reduced t3 production from t4 have both been observed in several clinical disorders, including hepatic cirrhosis, uremia, diabetes mellitus, and starvation. the question of whether glucagon has a direct effect on t3 production was studied in normal rats infused iv with [125i]t4 of [125i]t3 and 3 micrograms t4/day, using implanted minipumps. the blood [125i]t4 and [125i]t3 levels maintained a plateau between the fifth and ninth days of infusion. each ... | 1982 | 7042321 |
| genetic and physiological studies of the role of the rna ligase of bacteriophage t4. | 1982 | 7042981 | |
| processing of bacteriophage t4 transfer rnas. structural analysis and in vitro processing of precursors that accumulate in rnase e-strains. | 1982 | 7042984 |