Publications

influence of age and sex on the concentrations of thyroid hormone in serum in the rat.	studies of the influence of age and sex on the concentrations of total thyroxine (t4) and 3,5,3'-tri-iodothyronine (t3) in serum and on the free t4 and free t3 indices, were conducted in sprague-dawley rats of the cd strain varying in age between 10 days and 12 months. both sex- and age-related differences were found. in all age-groups studied, serum t4 concentrations were higher in the male than in the female, whereas serum t3 concentrations were higher in the female. in both sexes, concentrati ...	1982	7086320
serum free thyroxine values in term, premature, and sick infants.	free thyroxine concentrations were determined by radioimmunoassay in 96 infants within an intensive care nursery and in 32 healthy term infants. sera for free t4 levels were drawn simultaneously with the filter paper specimens for t4 obtained to screen these infants for congenital hypothyroidism. the mean free t4 level in 20 adults was 1.38 +/- 0.03 ng/dl (mean +/- sem). the mean in the icn infants was 3.48 +/- 0.18 ng/dl and in healthy term infants, 4.24 +/- 0.23 ng/dl. like t4, free t4 correla ...	1982	7086610
effects of chronic treatment with thyroxine and estradiol on estrogen concentration in serum and on hepatic microsomal catechol estrogen formation in female rats.	the effects of chronic treatment with thyroxine (t4) and estradiol on hepatic microsomal metabolism of estrogens to catechol products were studied and the extent to which activity in vitro correlated with serum estradiol concentrations in vivo was assessed. female rats were treated with either estradiol benzoate (eb; 56 micrograms/kg/day from silastic implants), t4 (50 micrograms/kg/day, s.c.) or combined eb + t4 for 35 days. animals treated with eb + t4, but not t4 alone, showed a significant i ...	1982	7086671
genetic analysis of bacteriophage t4 transducing bacteriophages.	mutations in the genes for nuclear disruption (ndd), endonuclease iv (denb), and the d1 region of the t4 genome are essential for converting bacteriophage t4 into a generalized transducing phage. these mutations gave rise to a very low frequency of transduction, about 10(-8) per infected bacterium. the addition of an rii mutation raised the transduction frequency about 20-fold. an additional 100-fold increase in the transduction frequency was observed with mutations in genes 42, 56, and alc. hig ...	1982	7086957
late events in t4 bacteriophage dna replication. iii. specificity of dna reinitiation as revealed by hybridization to cloned genetic fragments.	through the use of the technique of hybridization to cloned genes, the site specificity of the reinitiation of t4 dna replication was examined at late times after infection, when a large amount of dna had accumulated in the infected cell. replication was examined under two conditions; (i) when there was recombination but the repair of the recombinants was inhibited, and (ii) when recombination was followed by covalent joining. when no covalent repair of recombinant was allowed, reinitiation occu ...	1982	7086964
rat bladder irrigation with pvp-i2.	despite technical advances, foley catheter associated urinary tract infections continue to be the leading cause of nosocomial infections. pvp-i2 has been shown to be nonirritating to abraded tissue and we have shown that dilute solutions are bactericidal for organisms causing foley catheter associated urinary tract infections. the purpose of this study was to ascertain the toxicity of pvp-i2 on the catheterized rat bladder and to measure the systemic absorption of i2. bladder catheters were surg ...	1982	7087043
carcinoma of the base of the tongue: results of radical irradiation with surgery reserved for irradiation failure.	between 1964 and 1977, 95 previously untreated patients with squamous cell carcinoma of the base of the tongue received treatment with curative intent at the university of florida. eighty-six of the 95 patients (91%) had stage iii or iv disease at presentation. eighty-nine patients received radical courses of irradiation to the primary with or without neck dissection(s), with surgery reserved for salvage of irradiation failure. six patients underwent planned combined treatment of the primary les ...	1982	7087632
"unbound-analogue" methods for free t4: a note of caution.		1982	7088047
effect of chronic douching with polyvinylpyrrolidone-iodine on iodine absorption and thyroid function.	daily vaginal douching with polyvinylpyrrolidone-iodine in 12 euthyroid volunteers for 14 days resulted in a significant increase in serum total iodine concentration and urine iodine excretion. the increase in serum total iodine was associated with a marked decrease in 24-hour iodine 123 uptake by the thyroid and a small but significant increase in serum thyrotropin (tsh) concentration. however, values for serum tsh never rose above the normal range. no significant changes in serum thyroxine (t4 ...	1982	7088448
estramustine phosphate (estracyt) treatment of t3-t4 prostatic carcinoma.	from september, 1978, to november, 1980, 69 consecutive patients with locally advanced (t3-t4) prostatic adenocarcinoma, with or without distant metastases, were treated with oral estramustine phosphate. dosage was 15 mg/kg/day for 2 months, followed by 5 mg/kg/day until progression. in the 48 evaluable patients with progressive disease that entry in the study, 1 complete response, 7 partial responses, 31 disease stabilizations, and 9 progressions were encountered (81.2% npcp response rate). kar ...	1982	7088731
posthatch growth and development of a circadian rhythm for thyroid hormones in chicks incubated at different temperatures.	rhode island red eggs were incubated at 33.8 and 376.8 c from day 17 until hatching under a photoperiod of 12l:12d. after hatching, the same light schedule was maintained, and all chicks were raised at 25 +/- 1 c and 50% relative humidity. infrared lamps were used up to 7 days. pipping and hatching occurred significantly later in chicks incubated at 33.8 c, and the interval between events was prolonged. chicks of the 33.8 c group had a lower body weight on day 3 posthatch, but relative growth wa ...	1982	7088804
residual non-depolarising neuromuscular block assessed by train-of-four stimulation in the dog.	a technique is described for assessing the extent of residual neuromuscular block following non-depolarising agents in the dog. the ulnar nerve was electrically stimulated with a train-of-four impulses and the muscle responses recorded. heights of the control and, following the administration of the muscle relaxant, the first, second and fourth twitch tensions (t1, t2 and t4) of the train were measured. there was a highly significant linear correlation between the ratio t1/control, used to deter ...	1982	7089375
anatomical and biomechanical factors in the curve pattern formation of idiopathic scoliosis.	the maximum range of motion between two adjacent vertebrae without soft tissues was measured from c1-c2 down to l5-s and factors such as rotation, lateral bending, extension, and flexion, during surface contact movement of the facet joints, were investigated. thirty human cadaveric spines were studied. it was found that the individual spines had a characteristic level-dependent difference in the capacity for elementary motions at the facet joints. those segments with restricted motion capacity w ...	1982	7090760
hyperthyroidism caused by inappropriate thyrotropin hypersecretion: studies in patients with selective pituitary resistance to thyroid hormone.	we have identified the condition of thyrotropin (thyroid-stimulating hormone [tsh])-induced hyperthyroidism secondary to selective pituitary insensitivity to thyroid hormone in three patients. each patient was clinically hyperthyroid, with elevated serum levels of thyroxine (t4) and triiodothyronine (t3) and detectable levels of serum tsh before therapy. after therapy each patient had notably elevated tsh levels at a time that peripheral levels of thyroid hormones were in the hyperthyroid range. ...	1982	7092445
influence of tetraiodothyronine on hearing maturation in rats.	thyroid hormones are essential to the maturation of the central nervous system and sensory organs. hypothyroidism induced various kinds of neural retardation, including hearing deficits. despite careful attention to replacement therapy in human neonatal hypothyroidism, psychological disorders and cerebellar malfunction may occur in later life and may be related to overdoses. brain stem response audiometry (bsra) is used in this study as an indicator of acoustic pathway maturation in newborn rats ...	1982	7092704
ph-dependency of iodothyronine metabolism in isolated perfused rat liver.	1. isolated livers from fed male rats were perfused for 2 h with t4 (l-thyroxine), t3 (l-3,3',5-tri-iodothyronine) or rt3 (l-3,3',5'-tri-iodothyronine) at different ph values (7.1--7.6) in a fully synthetic medium, whereby normal metabolic functions were maintained without addition of rat blood constituents or albumin. 2. t3 output into the medium and net t3 production reached a maximum at a ph of the medium of 7.2 and significantly decreased with alteration of the ph when livers were perfused w ...	1982	7092838
thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage.	we have previously shown that changes occur in pyramids of area 17 of the rat visual cortex both after thyroidectomy (t) at 10 and at 40 days of age. to assess the effects of thyroxine treatment, instituted at different ages after t, two series of experiments were performed. a : rats were t at 10 days of age and either left untreated, or injected once daily with 1.5 micrograms thyroxine (t4)/100 g body weight. treatment was started at 12, 15, 20, 30 or 40 days of age. groups of untreated and t4- ...	1982	7093702
[monodeiodination of thyroxine to 3,3', 5-triiodothyronine and 3,3', 5'-triiodothyronine in human kidney homogenate (author's transl)].	the renal cortex, later proved by histology to be free of carcinoma, was obtained from the kidneys of 9 patients undergoing nephrectomy for hypernephroma or ureteral carcinoma. the cortex was homogenized in a cold 50mm tris-hcl buffer, ph 7.5, and centrifuged at 800 x g. supernatants (1.8 mg protein, referred to as "homogenate") were enriched with 2 micrograms of t4 and were incubated for varying periods at different temperatures. the t3 and rt3 formed were extracted into ethanol and measured by ...	1982	7095210
the interaction of free fatty acids in radioimmunoassays for reverse triiodothyronine.	we have investigated the effect of ffa on the ria of rt3 because of our previous findings of a correlation between serum rt3 values and increased ffa concentrations during prolonged exercise and reports of interference by ffa in other thyroid hormone assays. apparent rt3 values increased by 19% and 34% in in vivo studies of acute lipolysis in subjects 5 min post exercise or 10 min post heparin, respectively, while t3 and t4 concentrations were unchanged. varying concentrations of palmitic acid w ...	1982	7096540
acute effect of atenolol on serum thyroid hormones in hyperthyroid patients.	the effect of atenolol on serum thyroid hormones levels is controversial. to get more information on this problem we studied the effect of propranolol and atenolol on plasma thyroid hormone concentrations in 20 thyrotoxic patients. propranolol but not atenolol caused a significant decrease in t3 levels whereas no significant changes wee observed in t4 levels after both propranolol and atenolol administration.	1982	7096914
[cryotherapy in 141 cases of carcinoma of the prostate reviewed after 5 years (author's transl)].	141 patients with prostatic cancer, checked by biopsy, have been treated since 1975 till 1980 with cryotherapy and hormonotherapy. they have been compared with 60 patients who have received only hormones. there is a statistical difference in favour of the patients treated with cryotherapy, particularly in t3 and t4 stage. the best survival is plain especially in the first and third year. this improvement might depend on an immunologycal answer.	1982	7097031
a proposed structure of the prolate phage t4 prehead core. an electron microscopic study.		1982	7097842
identification of some bacteriophage t4 prereplicative proteins on two-dimensional gel proteins.	profiles of bacteriophage t4 early proteins resolved by a two-dimensional nonequilibrium ph gradient electrophoresis system (p. z. o'farrell, h. m. goodman, and p. h. o'farrell, cell 12:1133--1142, 1977) are presented. over 65 phage-induced proteins were resolved. amber or deletion mutants were used to identify 17 proteins in the gel patterns as the products of specific genes.	1982	7097860
response of thyroxine and triiodothyronine to thyroid-stimulating hormone in adult female baboons (papio cynocephalus).	the thyroxine (t4) and triiodothyronine (t3) response of the female baboon to injection of exogenous thyroid stimulating hormone was studied. this response established reference values for baseline and post-stimulation serum levels of t4 and t3. the reference values for t4 and t3 by radioimmunoassay were 9.9 +/- 2.2 micrograms/dl and 121 +/- 18 ng/dl, respectively. the t4 response to thyroid-stimulating hormone reached its peak level of 22.7 +/- 1.8 micrograms/dl at 12 +/- 2.5 hours. the corresp ...	1982	7098428
correlation of hepatic thyroxine 5'-monodeiodination with hexose monophosphate shunt in young rats.	the role of nadph and glutathione (gsh) in hepatic thyroxine (t4) 5'-deiodination and possible metabolic linkage between t4 converting system ad hexose monophosphate shunt were studied in young rats during maturation. low activity of t4 5'-deiodinase in young rats was enhanced 2-4-fold with the addition of 1 mm nadph and gsh in vitro, the effect of which was more prominent with nadph than with gsh. the highest enhancement was observed at 2-3 wk of age, whereas basal t4 5'-deiodinase activity was ...	1982	7099756
effect of dietary thyroid hormone on survival time during heat stress.	broilers were fed corn-soybean meal diets supplemented with either 3, 5, 3'-triiodothyronine (t3) or thyroxine (t4) for various time periods ranging from 8 to 26 days. survival times during heat stress were determined for females and males fed the control, t3, and t4 diets. serum hormone concentration for serums collected prior to heat stress was determined by radioimmunoassay. the combined results of both trials show significantly shortened survival times for t3 and t4 and that t3 had a much gr ...	1982	7100062
[radiotherapy of bladder malignomas with rapid electrons (author's transl)].	after having been submitted to mainly transurethral electroresection, a not selected group of patients (n = 143) with bladder carcinomas of different, mostly advanced stages (tis and ti = 4 patients, t2 = 33, t4 = 13) was irradiated with the circular accelerator (betatron) applying a telecentric pendulum method with a small angle. the total dose of 5100 rd (51 gy) which we wanted to achieve hitherto was administered to 129 patients; 14 patients received a lower dose. radiogenic complications wer ...	1982	7101332
effects and clinical significance of exogenous thyroxine therapy in patients with circulating thyroid hormone autoantibodies.	the effects of exogenous l-thyroxine therapy (0.2-0.3 mg/day) on spontaneously occurring thyroid hormone autoantibodies (thaa) and on serum levels of thyroxine (t4), triiodothyronine (t3) and reverse triiodothyronine (rt3) are described in a boy with lymphocytic thyroiditis. prior to t4 medication, thaa bound virtually all thyroid hormones as noted by serum gamma globulin binding of tracer hormones. during t4 therapy, however, gamma globulin binding of tracer thyroid hormones decreased markedly. ...	1982	7102608
clinical and hormonal characteristics in women with anovulation and insulin-treated diabetes mellitus.	clinical characteristics and basal hormonal parameters related to ovulatory function were investigated in 22 diabetic patients with anovulation (group 1) and in nine normally menstruating diabetic patients (group 2) and 45 nondiabetic patients with anovulation (group 3). no significant differences according to control of the diabetes were demonstrated within the two diabetic groups. groups 1 and 3 did not differ according to classification of anovulation. group 1 had significantly (p less than 0 ...	1982	7102763
thyroid function in patients with hyperemesis gravidarum.	an increased free thyroxine (t4) index was observed in 73% of 33 consecutive pregnancies complicated by severe hyperemesis gravidarum. the free triiodothyronine (t3) index was increased in only four of 11 hyperthyroxinemic patients. in five hyperthyroxinemic patients tested, no increase in serum thyrotropin was observed after the injection of thyrotropin-releasing hormone (thr). goiter, exophthalmos, or previous history of hyperthyroidism was absent in all patients. the thyroxinemia returned to ...	1982	7102767
bovine anaplasmosis: clinical, hematologic, and serologic manifestations in cows given a long-acting oxytetracycline formulation in the prepatent period.	the prophylactic efficacy of a long-acting oxytetracycline formulation was determined in 36 susceptible cows experimentally inoculated with anaplasma marginale. each of 10 cows in 3 treatment groups (t2, t3, t4) were given im injections of 20 mg of oxytetracycline/kg of body weight once, twice, or three times during the prepatent period. the t2 group was treated once at 1 week after experimental inoculation, the t3 group was treated 2 times (at 1 and 2 weeks) after exposure, and the t4 group was ...	1982	7103219
hypothyroidism secondary to biologically inactive thyroid-stimulating hormone secretion by a pituitary chromophobe adenoma: recovery after removal of the tumor.	a 50-year-old man, suffering from a large pituitary adenoma and panhypopituitarism, was found to have severely elevated thyrotrophin (thyroid-stimulating hormone [tsh]) levels (greater than 20.2 microunits/ml). the thyroxine (t4) level was low (less than 3.0 micrograms/dl). thyroid sodium iodide i 131 uptake was low (5% at 24 hours). a tsh test result was normal, with a 24-hour 131i uptake of 52% and a normal-looking thyroid gland on scintiscan. after surgical removal of the pituitary chromphobe ...	1982	7103637
one enzyme for the 5'-deiodination of 3,3',5'-triiodothyronine and 3',5'-diiodothyronine in rat liver.	many studies suggest that one enzyme is involved in the phenolic ring deiodination of iodothyronines in rat liver and kidney and another one in the tyrosyl ring deiodination. this study describes some characteristic of the phenolic ring (5'-) deiodination of rt3 and 3',5'-t2 by rat liver microsomes. at ph 7.2 the km values of the 5'-deiodination of rt3 and 3',5'-t2 were 0.103 and 0.77 microm, respectively. 3',5'-t2 and rt3 inhibited the respective 5'-deiodination reactions competitively, the ki ...	1982	7104033
the crystal structure of a major metabolite of thyroid hormone: 3,3',5'-triiodo-l-thyronine.	two independent conformations of the thyroinactive thyroid hormone metabolite, 3,3',5'-triiodo-l-thyronine (rt3) were determined by x-ray diffraction methods. the conformations show significant difference in the lettering geometry when compared with those of the thyroactive thyroxine (t4) and 3,5,3'-triiodo-l-thyronine (t3). the diphenyl ether conformation of the two conformers of rt3 is an anti-skewed one, in which the torsion angles, phi (c5-c4-o4-cl') are 8 degrees and -6 degrees, and phi' (c ...	1982	7104388
lack of sprouting and its presence after lesions of the cat spinal cord.	degeneration methods were used to study the dorsal root and descending projections after chronic partial denervation of adult cat spinal cord. conventional mapping methods were used, supplemented in some cases by densitometric measurements of the amounts of degeneration present. the amount of shrinkage of spinal gray matter in some sections was estimated by planimetric measurement. two preparations were used: (1) partial unilateral rhizotomy in which all dorsal roots caudal to t4 were cut except ...	1982	7104712
glucose turnover, gluconeogenesis from glycerol, and estimation of net glucose cycling in cancer patients.	a double isotope method was used in patients with progressive malignancy and in control patients to measure: glucose turnover, conversion rate of carbon skeleton of glycerol into glucose, and the interorgan cycling of glucose carbons (cori-cycle plus alanine-glucose cycle). [u-14c]glycerol and [6-3h]glucose were given intravenously as a single dose injection. the time course of the specific radioactivities of [6-3h] and [u-14c]glucose was followed in blood. the pool size and the turnover rate of ...	1982	7104955
cardiac catheterization dye does not affect serum thyroid hormone concentrations or tsh secretion.	the iodinated contrast agents used in oral cholecystography impair peripheral iodothyronine-5'-deiodinase activity, resulting in a transient decrease in serum 3,5,3'-triiodothyronine (triiodothyronine, t3) and in increases in serum 3,3',5'-triiodothyronine (reverse t3, rt3) and thyroxine (t4) concentrations. a related iodinated contrast agent, diatrizoate, is employed in coronary angiography. the effect of diatrizoate (renografin-76) on serum t4, t3, rt3, and thyroid stimulating hormone (thyrotr ...	1982	7105168
[combined surgical and radiologic treatment of anal cancer].	the different ways of metastases of carcinoma of the anus can hardly be removed by radical surgery and require other procedures than the lower carcinoma of the rectum. in comparing miles operation in t3/t4 carcinomas of the anus with the combined therapy of local excision and radiotherapy results showed no great difference in t1/t2 tumors the miles operation is not necessary. in t3/t4 carcinomas irradiation derives its worth from the few possible procedures ro radical surgery. in t1/t2 tumors ir ...	1982	7105898
[the use of competitive protein binding assay method for determining the amount of thyroxine (t4) in umbilical blood (author's transl)].		1982	7105905
autoradiographic demonstration of thyroid hormone binding to intact liver cells in vivo.	adult rats were injected intravenously with [125i]-3,5,3'-triiodothyronine (t3) of [125i]-thyroxine (t4). others were similarly treated, except for the addition of a 500-fold excess of the appropriate unlabeled hormone. light microscopic autoradiography of semi-thin sections of liver from these animals demonstrated high affinity, low capacity binding of t3 and, to a much lesser extent, t4 to the nuclei of the liver cells. labeling over the cytoplasmic portion of the cells was greater than that o ...	1982	7106046
ontogenesis of placental inner ring thyroxine deiodinase and amniotic fluid 3,3',5'-triiodothyronine concentration in the rat.	human and rat placentae contain enzymatic activity which converts t4 to rt3 and t3 to 3,3'-diiodothyronine and 3'-monoiodothyronine. this study presents data on the ontogeny of this inner ring iodothyronine deiodinase activity (p-t4ase) in rat placenta. p-t4ase was measured by quantitating the conversion of t4 to rt3 in 700 x g supernatants of placental homogenates. groups of rats were mated to permit the dams to be killed on the same day, on days 12, 14, 16, 18, and 20 of gestation. sufficient ...	1982	7106057
generation of a cloned nk cell line derived from the "null cell" fraction of human peripheral blood.	the present studies were designed to determine the conditions for generation of human nk clones. first the "null cell" (nc) fraction of human peripheral blood mononuclear cells, which contains the nk effectors, was purified using negative selection with anti-t3, anti-t8, anti-b1, and anti-mo2 monoclonal antibodies. subsequently, nc were cloned by limiting dilution using a combination of phytohemagglutinin (pha) and lymphocyte-conditioned medium (lcm) as an initial stimulus. colonies could be eas ...	1982	7108207
isolation and preliminary characterization of amber mutants of bacteriophage phi w-14 defective in dna synthesis.	of 42 amber mutants of bacteriophage phi w-14, 6 were defective in dna synthesis. three of the mutants synthesized dna in the nonpermissive host, but were defective in post-replicational modification of the dna. the dna synthesized by two of these mutants, am36 and am42, contained more thymine and less alpha-putrescinylthymine than did wild-type dna; that synthesized by the third mutant, am37, contained the normal amount of thymine, no alpha-putrescinylthymine, and hydroxymethyluracil. the prope ...	1982	7109031
genetic studies on capsid-length determination in bacteriophage t4. i. isolation and partial characterization of second-site revertants of a gene 23 mutation affecting capsid length.	the t4 mutation ptg19-80 affects the mechanism of capsid-length determination. it is located in gene 23, which encodes the major structural protein of the capsid. the mutation results in the production of abnormal-length capsids in high frequencies. this paper describes the isolation and partial characterization of second-site revertants of ptg19-80. in the course of their analysis, it was discovered that ptg19-80 is itself a double mutation consisting of a gene 23 mutation (ptg19-80c), which ca ...	1982	7109034
genetic studies on capsid-length determination in bacteriophage t4. ii. genetic evidence that specific protein-protein interactions are involved.	a bacteriophage t4 mutation (ptg19-80c) located in gene 23, which encodes the major structural protein of the t4 capsid, results in the production of capsids of abnormal length. mutations outside gene 23 which partially suppress ptg19-80c have been described in the accompanying paper (d. h. doherty, j. virol. 43:641-654, 1982). characterization of these suppressors was extended. a complementation test suggested that the suppressors were in genes 22 and 24. these genes coded for the major compone ...	1982	7109035
evidence for an internal component of the bacteriophage t4d tail core: a possible length-determining template.	the length of the t4 tail is precisely regulated in vivo at the time of polymerization of the tail core protein onto the baseplate. since no mutations which alter tail length have been identified, a study of in vivo-assembled tail cores was begun to determine whether the structural properties of assembled cores would reveal the mechanism of length regulation. an assembly intermediate consisting of a core attached to a baseplate (core-baseplate) was purified from cells infected with a t4 mutant i ...	1982	7109039
[measurement of free t4 and its clinical significance (author's transl)].		1982	7109265
[the thyroid hormones in alcoholic liver cirrhosis. clinical and prognostic aspects].	the authors confirm the clinical and prognostic importance of the measurement of circulating thyroid hormones - especially of triiodothyronine (t3) - in evaluating the decompensated phases of alcoholic liver cirrhosis. the assay was performed in 90 patients affected by liver cirrhosis and was compared with the clinical manifestations and other laboratory test: only prothrombin time was showed to be as useful as t3 concentration in following the clinical course of cirrhosis. low levels of tetraio ...	1982	7110605
effect of blocking t4-monodeiodination on hatching in chickens.	chick embryos were injected with iopanoic acid (iop) on either day 17 or 18 of incubation, and radioimmunoassays of triiodothyronine (t3) and thyroxine (t4) in serum and thyroid glands were performed from day 19 on through pipping and hatching and 1 day after hatching. the iop was able to block t4 to t3 conversion in chick embryos from day 19 of incubation. blocking t4 conversion did not delay hatching significantly, nor did it affect embryonic mortality significantly. yolk sac retraction was no ...	1982	7111131
effects of blinding or afternoon melatonin injections on plasma cholesterol, triglycerides, glucose, tsh and thyroid hormone levels in male and female syrian hamsters.	adult male and female hamsters (mesocricetus auratus) were divided into 3 treatment groups: intact, blinded, and intact hamsters which received daily sc injections of 25 microgram melatonin (mel) at 1700 h. after 10 weeks of treatment, thyroxine (t4), triiodothyronine (t3) and cholesterol levels in both male and female blinded or mel-treated animals were depressed compared to plasma titers of their respective intact control groups. plasma thyrotropin (tsh) levels were depressed by mel treatment ...	1982	7111335
thyroid hormones in male hamsters with activated pineals or melatonin treatment.	blinding resulted in gonadal and prostatic atrophy and reduced plasma thyroxine (t4), free t4 index (ft4i) and reverse triiodothyronine (rt3) levels in adult male hamsters housed in light-to-dark, 14:10 h. similar effects were seen after daily evening injections of 25 microgram melatonin. pinealectomy prevented the effects of blinding or melatonin injections. there were no pineal- or melatonin-induced decrements in t3 or thyrotrophin (tsh) concentrations. tsh was elevated by blinding in one expe ...	1982	7111336
[therapy of thyroid cysts with fine needle aspiration].	in a study extending over a period of 4 years, therapeutic fine-needle aspirations were carried out in 194 thyroid patients with thyroid cysts. the cyst contents of 3-130 ml cyst fluid were completely removed by suction in 2-3 month intervals by 1-17 fine-needle aspirations on an outpatient basis. malignancy was ruled out in all patients by repeated cytological tests. complete emptying of the cyst, verified by twice-repeated check at 3-month intervals, was achieved in 86 patients (44.3%). a redu ...	1982	7112060
the effect of acute spinal cord compression injury on thyroid function in the rat.	the effect of acute spinal cord injury on thyroid function was studied in rats subjected to severe spinal cord compression at t1. serum thyroxine (t4), effective thyroxine index (eti), and thyroid stimulating hormone (tsh) were measured at 1 and 100 minutes at one, three, and seven days after laminectomy and spinal cord injury. control animals were subjected to laminectomy only. t4 was decreased at 1 minute after laminectomy with or without spinal cord injury, though the animals with cord injury ...	1982	7112391
experimental conditions leading to a low degree of thyroglobulin iodination without loss in coupling efficiency.	the hormone content of in vitro iodinated thyroglobulin is a constant fraction of the iodine content of the protein under most, but not all, experimental conditions. in contrast, in vivo iodinated human thyroglobulin may contain as little as 10% or as much as 50% of its total iodine in the t4 molecules. surprisingly, in some poorly iodinated thyroglobulins up to 30% of the iodine may be found in t4. the mechanism of the apparent dissociation between iodination and coupling efficiency (i.e. perce ...	1982	7113586
the effect of starvation and refeeding with oral versus intravenous glucose on serum 3,5-,3,3'-and 3'-5'-diiodothyronine and 3'-monoiodothyronine.	the effect of complete fasting on the serum concentrations of the iodothyronines 3,5-diiodothyronine (3,5-t2), 3,3't2, 3', 5'-t2 and 3'-monoiodothyronine (3'-t1) was evaluated. fourteen obese women underwent a complete fasting for 4 days. caloric restriction resulted in the following serum hormone levels (before vs 3. day): t4: 103 vs 109 nmol/l (ns), t3: 1.83 vs 1.24 nmol/l (p less than 0.01), rt3: 0.276 vs 0.407 nmol/l (p less than 0.01), 3.5-t2: 70 pmol/l (ns), 3.3'-t2: 42 vs 39 pmol/l (p les ...	1982	7113605
peripheral metabolism of thyroid hormones in vitamin a-deficient rats.	some aspects of thyroid hormone metabolism were studied in rats on a vitamin a-deficient diet for 7-8 weeks. it was shown that, in deficiency, thyroxinemia, the extrathyroidal thyroxine (t4) pool and the t4 biological half-life were increased, and the t4 distribution space and the t4 disposal rate were similar to those in control rats. the in vitro formation of triiodothyronine (t3) from t4 by liver microsomes was slightly decreased under basal conditions but similar after addition of glutathion ...	1982	7114797
[clinical significance of triiodothyronine (t3) measurement].	the clinical significance of t3 assay is related to the discovery of t3 thyrotoxicosis, a form of hyperthyroidism caused by an overproduction of alone t3 with normal value of t4. we evaluated the prevalence and the clinical features of this form in a group of 850 subjects who were submitted to clinical examination and hormonal thyroid assay. we showed that t3 thyrotoxicosis is a mild condition of hyperthyroidism.	1982	7115581
direct quantitative estimation of several iodothyronines in rat bile by radioimmunoassay and basal data on their biliary excretion.	a method was developed for the hydrolysis of conjugated iodothyronines in bile with the aid of beta-glucuronidase/arylsulfatase and for subsequent direct estimation of total and free iodothyronines with the aid of specific radioimmunoassay. the amount of conjugated fraction could then be calculated from the difference. thus, basal biliary excretion of several iodothyronines was measured in 31 normal, fed rats in which the bile duct was drained with polyethylene tubing under pentobarbiturate anes ...	1982	7115759
interlaboratory comparison of serum thyroxine analyses.	approximately 300 clinical chemistry laboratories participated in a survey of measurements of the thyroxine (t4) concentration in 13 lyophilized serum specimens prepared by spiking a base serum pool with several different levels of t4. of 35 commercially available kit methods, 4 kits were used by 30 or more laboratories, and 9 by 10 or more laboratories. values obtained with the abbott or nuclear medical laboratories, kits, which were used by one-third of all laboratories that named a specific k ...	1982	7116625
the effect of acceptor oligoribonucleotide sequence on the t4 rna ligase reaction.	in order to make efficient use of t4 rna ligase in a program involving chemical-enzymatic oligoribonucleotide synthesis, the sequence effects of the acceptor oligomer have been refined. the reaction of the donor molecules pcp and pupupupcp with a series of trinucleoside diphosphates apapn, cpnpa and npcpa (where n = u, c, a or g) was examined. high-performance liquid chromatography was used for simultaneous analysis of all substrates, intermediates and products. for all trinucleoside bisphosphat ...	1982	7117259
altitude-induced changes in plasma thyroxine, 3,5,3'-triiodothyronine, and thyrotropin in rats.	we have studied the thyroid function of high-altitude-acclimated (6,900 m for 5 wk) and nonaltitude-acclimated control (198 m) rats. after 5 wk of high-altitude exposure the plasma concentrations of both thyroxine (t4) and triiodothyronine (t3) were lower than those in control rats (4.7 +/- 0.3 vs. 3.3 +/- 0.2 microgram/dl and 96 +/- 5 vs. 74 +/- 6 ng/dl, respectively). the plasma thyrotropin (tsh) concentration was elevated in the high-altitude-acclimated rats compared with controls (52 +/- 4 v ...	1982	7118652
action of t4 endonuclease v on polydeoxyribonucleotides with apyrimidinic or apurinic sites.	[3h]thymine-labeled poly(da) . poly(dt) carrying many apyrimidinic (ap) sites has been prepared by treating an enzymatically synthesized poly(da) . poly(dt, du) with uracil-dna glycosylase. incubation of the polymer with a homogeneous preparation of t4 endonuclease v resulted in conversion of the labeled material into acid-soluble forms. native dna with apurinic sites was also cleaved by the enzyme. single-stranded polymers, poly(dt) carrying ap sites or poly(dt) with thymine dimers, were barely ...	1982	7118862
treatment results of combined high-dose preoperative radiotherapy and surgery for oropharyngeal cancer.	fifty eight patients receiving planned high-dose preoperative radiotherapy followed by en bloc oro-mandibular-cervical resection for oropharyngeal cancer were reviewed. these patients received continued close observation and care from both the otolaryngology and radiotherapy services. in light of the ongoing controversy of preoperative vs. postoperative radiotherapy, we present our data demonstrating the value of preoperative radiation. an overall tumor control rate of 66% was achieved, with an ...	1982	7121170
noradrenaline turnover during under- and over-eating in normal weight subjects.	adjustments to sympathetic nervous system activity may regulate constant body weight despite wide variations in energy intake. to test this six normal weight subjects were studied at three different energy intakes (low, weight maintaining and high). noradrenaline turnover was measured on the tenth day of each diet. both noradrenaline appearance rate and noradrenaline clearance increased significantly with increasing energy intake and were a more sensitive indices than the plasma noradrenaline co ...	1982	7121260
bioavailability of thyroid hormones from oral replacement preparations.	we evaluated gastrointestinal absorption in normal subjects of t4 and t3 from synthetic t3 tablets (cytomel, skf), desiccated thyroid tablets (armour), thyroglobulin tablets (proloid, warner-chilcott) and synthetic l-t4 tablets (synthroid, flint and levothroid, armour). measurements of serum t4 and t3 concentrations and free hormone indices were made at multiple times after tablet ingestion, and t3 content in tablets was measured by radioimmunoassay. the time to peak serum t3, and the 26 hr inte ...	1982	7121261
[thyroid hormone level in the serum in untreated hypothyroidism and in substitution therapy].	forty-seven patients with clinically revealed hypothyrosis were examined. of these, 31 subjects were untreated and 16 were in a compensatory stage of the disease after the substitution treatment. all the untreated patients had lowered serum concentration of total thyroxin (tt4) and free thyroxin (ft4i) indices, their mean arithmetical values being statistically different in the mild and moderate stages of the disease. the total triiodothyronine (t3) level was within normal in 10 of 31 patients. ...	1982	7122443
[characteristics of the clinical aspects, and hormonal and immunological status of thyrotoxicosis patients with a hereditary predisposition to endocrine diseases].	the levels of triiodothyronine (t3), thyroxine (t4), tth, sth, free triiodothyronine index t3f/t3/t4, as well as the titers of antibodies to microsome-membranous antigen and thyroglobulin, were studied in thyrotoxic patients with hereditary predisposition to endocrine diseases (thyrotoxicosis, goiter, diabetes mellitus) and in subjects without such heredity. peculiarities of the disease development and endocrinopathy distribution among their relatives were investigated. more pronounced disorders ...	1982	7122451
effects of hyper- and hypothyroidism on the basal levels of angiotensin i and kinetic parameters of renin-angiotensin system in male rats.	the basal levels of angiotensin i and kinetic parameters of renin-angiotensin system were studied under control, hyper- and hypothyroidism conditions. the serum levels of triiodothyronine (t3) and thyroxine (t4) and plasma angiotensin ii have been measured radioimmunoassay. hyperthyroidism was induced by 5.5 micrograms/200 g of t3 or 100 micrograms/200 g of t4 administration for 12 days, and hypothyroidism by propylthiouracil (ptu) administration of 1 mg/200 g for 12 days. basal levels of angiot ...	1982	7122971
hyperthyroidism and pregnancy. ii. thyroid function in normal pregnancy and in pregnancy associated with hyperthyroidism.	starting from the diagnostic difficulties when hyperthyroidism is associated with pregnancy, pbi, total t4 and free thyroxin, triiodothyronine (t3), rt3, tbg, tsh and lats were assayed in a group of euthyroid pregnant women (136) more or less equally distributed between month 2 and 9 of pregnancy; the same tests were applied to 14 pregnant hyperthyroid women (month 2-3), the latter also undergiving a test for urinary elimination of catecholamines. the results were referred to the normal values o ...	1982	7123131
hypothyroidism in zambia.	nine patients with clinical and laboratory evidence of hypothyroidism are reported on. all had primary hypothyroidism; 8 were females and 1, the only indigenous zambian in the group, was male. the mean serum thyroxine (t4) level (+/- 2 sd) in the 9 patients before optimal replacement therapy with l-thyroxine was 3,2 +/- 2,8 microgram/dl. in 3 patients on optimal replacement therapy it was 9,3 +/- 1,2 microgram/dl. this difference is statistically significant (p less than 0,01). the mean serum-tr ...	1982	7123430
radiotherapy as initial treatment for carcinomas of tonsillar region.	for this study we have reviewed 186 carcinomas of the tonsillar region, i.e., the lateral wall of the oropharynx, treated from january 1959 to december 1973 at this institute. in 148 patients (79.6%) the primary tumor and the lymphatic areas were treated with 60co-teletherapy (tct). in 15 cases (8.1%) the primary lesion was removed by transoral surgery, followed by irradiation of the tonsillar region and lymphatic areas with tct. in 23 patients (12.3%) the primary tumor was treated with intersti ...	1982	7123671
[thyroid function in healthy premature infants and in premature infants with the hyaline membrane syndrome ].	the serum concentrations of thyrotropin (tsh), thyroxine (t4), trijodothyronine (t3) and of 3,3',5', trijodothyronine (reverse t3, rt3) were followed up during the first 4 weeks of life in 5 healthy premature infants and in 6 premature infants with hyaline membrane syndrome and artificial ventilation. tsh and t4 concentrations remained unchanged in both groups. t3 levels increased during the observation period and were significantly lower in the sick prematures on days 1 and 3 (p less than 0,02) ...	1982	7123958
circulating tsh-binding inhibiting immunoglobulins in myasthenia gravis.	using a radioligand receptor assay the sera of 46 patients with myasthenia gravis (mg) were tested for the presence of circulating tsh-binding inhibiting immunoglobulins (tbii). in addition thyroid function was evaluated on the basis of t3, t4, tbg and tsh radioimmunoassays including the trh stimulation test. circulating antimicrosomal and antithyroglobulin thyroid antibodies were measured by haemagglutination techniques. two patients had concomitant graves' disease (gd), 5 were euthyroid with a ...	1982	7124292
carcinoma of the subglottic larynx.	primary epidermoid carcinoma of the subglottic region is extremely rare. review of the tumor registry at memorial sloan-kettering cancer center over the past 25 years showed only 16 patients who could be classified as having primary carcinomas arising in the subglottic larynx. their ages ranged from 33 to 77 years. there were 13 men and 3 women. the most common symptom was hoarseness of voice (13 patients), followed by respiratory difficulty, and hemoptysis. one patient had stage i disease, two ...	1982	7125077
the use of high-performance liquid chromatography in the isolation and analysis of oligoribonucleotides synthesized by the t4 rna ligase reaction.		1982	7125226
[fundamental and clinical evaluation of immo phase free t4 radioimmunoassay kit].		1982	7127868
prolonged persistence of a large pericardial effusion and hemodynamic evidence of cardiac tamponade during treatment of myxedema.	we describe clinical, echocardiographic, and catheterization findings that were present initially and during therapy in a myxedematous patient with a large pericardial effusion and tamponade. treatment with thyroxine resulted in a marked improvement of most of the clinical features of hypothyroidism and some improvement in cardiac function. however, the pericardial effusion as well as clinical and laboratory evidence of tamponade persisted for 2 months after full replacement doses of t4 had been ...	1982	7127923
postnatal development of corticosteroid-binding globulin: effects of thyroxine.	the aim of this study was to examine the temporal and dose characteristics of the corticosteroid-binding globulin (cbg) response to t4 and to determine whether this response is due to stimulation of hepatic biosynthesis of cbg. when n-propylthiouracil (ptu)-induced hypothyroid pups were given a single injection of t4 (0.1 microgram/g bw) on postnatal day 5, 6, or 7, only pups treated on day 7 showed a significant increase in cbg. in a t4 dose-response study conducted with 5- and 8-day-old pups, ...	1982	7128523
effect of cimetidine on prolactin secretion in normal controls and hyperthyroid patients.	nine healthy female controls and 10 hyperthyroid female patients were studied. the intravenous administration of 200 mg cimetidine, an h2-receptor antagonist, was followed by a significant and marked rise in serum prolactin levels in all control subjects. there was no significant difference in serum prl response to cimetidine injection between the euthyroid controls and hyperthyroid patients. but max delta prl, the change from basal to peak values, is significantly lower in the hyperthyroid pati ...	1982	7128538
effect of cold exposure on thyroid hormone in fischer 344 rats of increasing age.	male rats aged 6 weeks, 6 months, and 18 months were kept at 4 to 5 degrees c for 12 days and compared with age-matched controls at room temperature as to survival, weight change, food consumption, core body temperature, and several parameters of thyroid hormone economy. after 12 days in the cold, 14%, 50%, and 71% of 6-week-, 6-month-, and 18-month-old rats, respectively, were living. weight declined in both older groups, though at a faster rate in the oldest. increasing age did not affect seru ...	1982	7130641
[studies on the measurement of serum free thyroxine with amerlex free t4 ria kit].		1982	7131920
retarded fetal brain development resulting from severe dietary iodine deficiency in sheep.	sheep have been used to study the effect of dietary iodine deficiency on the development of the fetal brain. severe iodine deficiency caused reduction in fetal brain and body weights and in brain dna and protein from 70 days gestation to parturition. the lowered brain weight and brain dna at 70 days gestation indicates a reduced number of cells, probably due to slower neuroblast multiplication which normally occurs from 40-80 days in the sheep, and the reduction in dna and protein after 80 days ...	1982	7133315
effects of melatonin on thyroid physiology of female hamsters.	the effects of melatonin administration on thyroid physiology of female hamsters was investigated. a protocol of 25 micrograms given daily as subcutaneous injections late in the light period was found to inhibit blood levels of thyroxin (t4), triiodothyronine (t3) and thyrotropin (tsh). the free t4 index (ft4i) and the free t3 index (ft3i) were also significantly inhibited by melatonin injections. decreasing the photoperiod under which the hamsters were kept, from 14 h light/10 h dark (14l/10d) ...	1982	7133320
[variations in blood levels of t3, t4, and tsh in relation to sex].		1982	7134530
castration induces a marked reduction in the incidence of thyroid cancers.	although thyroid disease in humans predominates in females, the prognosis of thyroid cancer in males is much less favorable. to further explore the role of male sex hormones, we utilized the experimental model of radiation-induced follicular cancer in the rat, studying the effects of castration on tumor development. microscopic evidence of tumor formation was correlated with the biochemical parameters serum thyroxine (t4), thyrotropin (tsh), and thyrocalcitonin (tc) at 24 months. the incidence o ...	1982	7135205
[combination of radiotherapy and selective chemotherapy in the treatment of advanced ovarian carcinomas].	a report is given on 160 patients suffering from ovarian carcinomas the stages which were exactly determined by tnm classification. 32 patients had tumors of the stages t1-t3, 128 patients had tumors of the stage t4. all t3 subgroups showed favorable results after radical surgery and a postoperative combination of radiotherapy and selective cytostatic chemotherapy. the therapy plans including radiotherapy had more advantages than those without radiotherapy. furthermore, the cytostatic treatment ...	1982	7135445
[observations of the thyroid function after treatment of the laryngeal carcinoma with 60co].	we have examined 16 patients with laryngeal carcinomas who had been submitted to laryngectomy and subsequent 60co therapy (dose 60-70 gy, thyroid exposure 50-60 gy). after an interval of several years, some patients showed alterations of the thyroid function, i.e. a problematic hypothyreosis in two patients and a latent or compensated hypothyreosis in six patients. the latter could be demonstrated by several functional in-vitro tests (t3 saturation, t4, t3-ria, tshv, trh). especially the trh tes ...	1982	7135447
nontoxic goitre. ii. a study of the pituitary-thyroid axis in 14 recurrent cases.	of 182 patients operated on for nontoxic goitre, 162 could be followed up after a mean period of 16.4 years. in 31 (19%) of the 162 patients the goitre had recurred. no patient had received regular thyroid-substitution therapy postoperatively. of the 31 recurrences, 14 had not been treated at the time of follow-up. these 14 patients were matched with controls (without recurrence) from the original series, according to sex, age and time of operation. thyroid-stimulating hormone (tsh), serum thyro ...	1982	7136422
dissociation of growth and function in the rat thyroid during prolonged goitrogen administration.	this study was designed to investigate the changes in growth and function which occur in the rat thyroid during prolonged tsh stimulation. animals maintained on the goitrogen aminotriazole were sacrificed together with controls at frequent intervals over a period of 5 months. the levels of serum t3 and t4 and tsh were measured by radioimmunoassay. functional activity was assessed by measurement of the thyroid/serum iodide ratio (t/s) and growth by measurement of thyroid weight, follicular cell n ...	1982	7136448
[treatment of carcinomas of the vallecula and epiglottis by supraglottal surgery. indications and therapeutic results].	a study of 87 cases of carcinoma of the vallecula and the epiglottis (margin and vestibulum) with the common feature of an essentially identical surgical technique: supraglottal horizontal laryngectomy. in the case of vallecular lesions (34 cases from t1 to t4) this operation, performed from below upwards with lymph node dissection and associated with postoperative radiotherapy, gave oncological results identical to those of total laryngectomy and better than those of other protocols based upon ...	1982	7137780
absorption and half-life of bovine, caprine and ovine igg1 in the newborn lamb. effect of experimental prematurity and endocrine factors.	the influence of experimental prematurity and endocrine factors on the absorption and half-life of bovine igg1 was studied in newborn limousin x romanov lambs. six preterm and six full-term animals were bottle-fed with a common bovine colostrum pool during 32 h, whereas seven preterm and six full-term lambs were fed with the same bovine colostrum 2 h post-partum, a caprine colostrum 8 h after birth and an ovine colostrum 16 h post-partum. in the first group, the maximal plasma igg1 levels were n ...	1982	7137854
staging of supraglottic cancer.	in 1977, the american joint committee for cancer staging and end-results reporting (ajc) revised its 1972 staging system for supraglottic cancer of the larynx. these changes included the following: (1) reclassifying t1b carcinomas as t2 carcinomas, (2) reclassifying extension onto the medial wall of the piriform sinus or postcricoid mucosa as t3 carcinomas rather than t4 carcinomas, (3) restructuring of the n classification, and (4) changing the classification of t4 no carcinomas from stage iii ...	1982	7138362
the role of the thyroid hormones on the decrease of cholesterolemia produced by a thymus fraction.	the purpose of this paper is to establish whether the hypocholesterolemic effect of thymus fraction administered to rats fed on a fat diet is correlated to an activation of thyroid. by determining the plasma levels of t3,t4 by kit set/ria and tsh by the method of jaquet et al., modified for rats, the authors may exclude this hypothesis confirming the results of comsa et al, of an inhibitory effect of thymus in tsh secretion.	1982	7138671
[fetal head growth retardation due to maternal antiepileptic drug use--with reference to gh, tsh, t4, t3 and r-t3].		1982	7138698
subcellular distribution of iodothyronine 5'-deiodinase in cerebral cortex from hypothyroid rats.	we have examined iodothyronine deiodination in subcellular fractions of cerebral cortex obtained from hypothyroid rats. enzymatic activities were measured at 37 degrees c in the presence of 20 mm dithiothreitol with 125i-labeled t4 and 125i-labeled rt3 as substrates for 5'-deiodination and 131i-labeled t3 as the substrate for the 5-deiodinase. reaction products were separated by descending paper and/or ion-exchange chromatography. cerebral cortex subcellular fractions were also characterized by ...	1982	7138901
early barbiturate treatment eliminates peak serum thyroxine levels in neonatal mice and produces ultrastructural damage in the brains of adults.	serum thyroxine levels peak sharply at the end of the second postnatal week in mice. treating neonatal mice with barbiturates (phb) completely eliminates this marked thyroxine (t4) peak without significantly affecting nonpeak levels at other ages. phb treatment at this same time also establishes or induces long-lasting degenerative processes that continue to result in ultrastructural neural deficits in adults, long after treatment has been discontinued. similar neural deficits have been observed ...	1982	7139349
32p-postlabeling analysis of non-radioactive aromatic carcinogen--dna adducts.	a newly developed enzymatic 32p-postlabeling method was applied to the analysis of dna's containing non-radioactive arylamine, arylamide, and polycyclic aromatic hydrocarbon adducts. dna reacted in vitro with n-hydroxy-2-amino-fluorene, n-acetoxy-2-acetylaminofluorene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, respectively, as well as dna preparations from the liver of rats treated with n-hydroxy-2-acetylaminofluorene and benzo[a]pyrene, respectively, ...	1982	7139866
[studies of t4 determination by solid-phase radioimmunoassay for mass screening of congenital hypothyroidism].		1982	7139988
cyclical changes in serum thyroid hormone concentrations related to hemodialysis: movement of hormone into and out of the extravascular space as a possible mechanism.	chronic hemodialysis (chd) patients suffer from a chronic illness that is believed not to involve the thyroid. however, they may have low serum t4 and t3 concentrations. the influence of a single hemodialysis treatment on serum thyroid hormone concentrations was studied in twenty-three chd patients. it was found that serum total t4 and free t4 concentrations were significantly higher immediately after hemodialysis than before treatment. immediately after hemodialysis serum t3 and tsh concentrati ...	1982	7140033
hypermetabolic low triiodothyronine syndrome of burn injury.	the free tetraiodothyronine index (ft4i) and free triiodothyronine index (ft3i) in burn patients represented the serum levels of free (dialyzable) t4 and free t3, respectively. ft4i and ft3i were lower with greater burn size and were lower in nonsurvivors than expected for the burn size. there was no compensatory elevation of basal or releasing hormone-stimulated thyrotrophin (tsh) concentrations. reverse t3 was higher with greater burn size. t3 treatment restored ft3i but did not affect mortal ...	1982	7140337