Publications

pituitary-thyroid axis after bilateral orchiectomy in men.	the functional interaction between the testis and thyroid was evaluated in 13 patients affected by prostatic carcinoma before and after bilateral orchiectomy. two different patterns of thyroid hormones were noted. immediately after surgery, free thyroxine (t4) increased and total triiodothyronine (t3) decreased probably as a result of surgical stress at anesthesia. later, free t4 levels decreased while total t4 and thyroxine binding globulin (tbg) were unchanged. such changes may be due to quali ...	1982	6816159
structure-function relationships in escherichia coli translational elongation factor g: modification of lysine residues by the site-specific reagent pyridoxal phosphate.	translational elongation factor g (ef-g) of escherichia coli was modified with the selective, site-specific lysine reagent pyridoxal phosphate (plp). the reaction results in the modification of a maximum of 12 lysine residues, one of which is essential for guanosine 5'-triphosphate (gtp) binding and whose modification is inhibited by the presence of gtp. formation of a reversible adduct between 2,3-butanedione and an essential arginine similarly located in the gtp binding site [rohrbach, m.s., & ...	1982	6816267
thyroid abnormalities in patients with myotonic dystrophy.	myotonic dystrophy (md) is a systemic genetic disorder predominantly affecting musculature. although endocrine disturbances have been described, data relating to thyroid gland involvement are sparse and conflicting. to further investigate this aspect, twenty md patients and twenty age-and sex-matched controls were studied. all were clinically euthyroid and there were no significant differences between circulating levels (mean +/- sd) of t4 (101 . 5 +/- 28.2 v. 103 . 8 +/- 27 . 7 nmol/l), t3 (1 . ...	1982	6816488
an improved method for the estimation of relative binding constants of t4 and its analogues with serum proteins.	a new method is reported for the determination of the binding constants of homologous ligands relative to that of the parent ligand. the technique minimizes the effects of random and bias errors inherent in absolute methods and obviates the need to quantitate the radiolabelled tracer concentration. in addition, it is likely to be of general applicability for monovalent proteins. the method has been applied in the determination of the binding constant (relative to that of t4) of the t4-analogue t ...	1982	6816492
the trh test in normal subjects: methodological considerations.	changes in serum tsh, prl, gh, t3, t4 and ft4-index after injection of trh (500 micrograms i.v.) were measured in 13 normal women and 12 normal men. in both sexes, tsh and prl concentrations rose significantly over baseline after trh injection (p less than 0.01). the prl response, but not the tsh response, was significantly lower in men than in women. although most tsh and prl peaks occurred about 30 min after trh injection, a delayed prl peak was seen in four men. thyroid hormones also rose sig ...	1982	6817359
group and type distribution of beta-haemolytic streptococcus strains in belgrade, yugoslavia, 1973-1980.	group and type differentiation by griffith' method of agglutination was performed on 7514 haemolytic streptococcal strains isolated from patients with acute streptococcal infections. thirteen different groups were found--the most frequent were groups a (63.0%), b (12.5%), c (8.1%) and g(2.5%). the group a was predominant among strains isolated from upper respiratory tract, but in later years the frequency of group a strains among streptococci causing respiratory infections was significantly lowe ...	1982	6817541
[in vitro and in vivo diagnosis of borderline hyperthyroidism].	the evaluation of "preclinical hyperthyroidism" includes laboratory and in vivo tests. the measurements of circulating total thyroxine (t4) and total triiodothyronine (t3) depend on the plasma concentration of thyroid hormone binding proteins. a simple approach, the calculation of the free t3 index (ft3i) and the augmented ft3i (aft3i) from total t3 and t3-resin uptake corrects the total serum t3 for variation in thyroid hormone binding capacity. in a group of 95 patients with border-line elevat ...	1982	6818529
[clinical significance of free serum thyroxine--comparative studies with 5 methods].	in order to check whether the serum free t4 as obtained with commercially available kits can substitute for total t4 measurements in the routine diagnosis of thyroid disorders, serum ft4 was simultaneously assayed using 5 different methods (amerlex; gammacoat; immo-phase; liquisol; t4/tbg) in 152 subjects. overt hyper- and hypothyroidism were readily distinguished from euthyroidism with each method. discrepant ft4 results, however, were obtained with these assays in clinically euthyroid subjects ...	1982	6818530
[diagnostic value of ft4 concentration and t4/tbg radio--better discrimination with ft4 in marked tbg anomalies].	in 211 consecutive patients t4/tbg ratio correlated well with direct ft4 determination over a wide range of tbg concentration. however, there was a tendency to decreasing t4/tbg ratios with an increase of tbg concentration, which in consequence did lead to false results in three patients with very high tbg concentrations. direct ft4 determination, which is not influenced by the binding protein levels, therefore is superior to t4/tbg ratio in patients with very low or high tbg concentrations.	1982	6818531
[diagnosis of triiodothyronine thyrotoxicosis].	the effectiveness and safety of different methods of radioimmunoassay to determine the thyroid function were studied in 298 patients: 172 with nodose toxic goiter and 116 with nodose euthyroid goiter. a "warm", "hot", "cold" and "autonomic" nodes, respectively, prevailed in nodose goiter, on skanning. free triiodothyronine index and elevated serum triiodothyronine index (est3i) were calculated to determine the effect of thyroxin-binding ability of globulin on the total triiodothyronine level. th ...	1982	6818538
thiol-beta-lactamase: replacement of the active-site serine of rtem beta-lactamase by a cysteine residue.	we describe a procedure by which the codon (agc) for the active-site serine-70 of pbr322 beta-lactamase (penicillinase, penicillin amido-beta-lactamhydrolase, ec 3.5.2.6) is altered to that for cysteine (tgc). the pertinent nucleotide bases, a-g-c-a, positions 410-413, of pbr322 are excised by treating a limited hgiai digest of pbr322 with the 3' leads to 5' exonuclease of t4 dna polymerase. the new sequence, t-g-c-a, is inserted in two steps. first, the kpn i molecular linker d(t-g-g-t-a-c-c-a) ...	1982	6818541
triiodothyronine (t3) binding to immunoglobulin g subclasses in a slightly hypothyroid woman.	a 44-year-old woman, with an earlier history of myxoedema, had stopped taking thyroxine and was found to have both a slightly elevated basal tsh level and an increased tsh response after thyroliberin stimulation. the t4 value was low borderline, and using a radioimmunoassay that separated free and antibody-bound hormone by polyethylene glycol precipitation, the t3 value was found to be less than zero. this last finding was explained by the existence of t3 antibodies in the patient's serum. the a ...	1982	6818676
[concentration of progesterone and thyroxine in the luteal phase of the cycle in heifers after administration of estradiol benzoate].	the effect of current 48-hour infusion of estradiol benzoate (eb) on the dynamics of the concentration of progesterone (p) and thyroxine (t4) was studied in four heifers in the luteal stage of their cycle. the parameters were evaluated in three intervals: infusion (a), post-infusion (b) and "uninfluenced" interval (c). in the course of infusion the concentrations of p in three animals had a markedly descending tendency. the p concentration increase in the 36th hour of infusion was maintained als ...	1982	6818747
impaired secretion of tsh in critically ill patients with 'low t4-syndrome'.	thyroid and pituitary function was studied in 10 male and 6 patients female during critical non-endocrine disease. low concentrations of tt3 were observed in each case. seven patients out of whom 3 survived, presented with low levels of tt4 due to deficiency in tbg in the presence of normal values of fti and ft4, whereas a 'low t4-syndrome', characterized by low concentrations of both tt4 and ft4 was seen in 9 patients, 8 of whom died 1 to 16 days after evaluation of pituitary function. a dimini ...	1982	6818804
[effects of the graft versus host reaction on the thyroid gland: evidence of correlations between the severity of the immunological conflict and the disease of thyroid activity in the chick embryo].	the allograft of chicken spleen to homologous embryo recipients aged 9 days induces a systemic graft versus host reaction. in the 8 days after grafting, the recipients show a mesenchymatous goitre. the severity of the immunological conflict, expressed with the spleen index, and the decrease of thyroid activity, detected by follicle number reduction and t4 level fall, are closely linked; these findings indicate that, in this model, thyroid is a target organ of the immunological conflict.	1982	6819064
pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-t4 syndrome".	thyroid function tests were obtained from 335 consecutive patients admitted to an intensive care unit. twenty patients suffering from severe non-endocrine diseases (septicaemia, fulminant hepatic and renal failure, acute pancreatitis, polytrauma, cerebral haemorrhage) were found to have serum thyroxine levels in the hypothyroid range (less than 4 micrograms/dl). serum concentrations of total thyroxine (2.3 +/- 0.2 micrograms/dl), triiodothyronine (0.23 +/- 0.03 ng/ml), and thyroxine binding glob ...	1982	6819131
effects of cimetidine on thyroid hormones.	short-term administration of the h2-antagonist cimetidine (400 mg three times/day for 5 days) was performed in eight healthy male volunteers and its effects on both thyroid hormone levels and on hypophyseal hormone release induced by acute hypoglycaemia and trh were tested. absolute values of basal and post-trh serum t3 were decreased by treatment, while basal and stimulated serum rt3 and t4 levels were not altered significantly. cimetidine administration did not change the hormone release induc ...	1982	6819899
effects of oral and intravenous trh and metoclopramide on prl and tsh secretion in women.	pituitary secretion of prl and tsh is under the control of inhibitory dopaminergic and stimulatory trh-mediated mechanisms. to evaluate the relationships between these regulatory systems, ten healthy women were treated with oral trh (20 mg twice daily), a dopamine blocking drug, metoclopramide (mc) (10 mg t.d.s.) or placebo for 1 week (from 8th to 14th cycle day). serum concentrations of prl, tsh, t3 and t4 were determined before, at the end, and 3 days after the treatments. in addition, prl and ...	1982	6819904
[effect of acute intravenous administration of thyroliberin on circulating reverse-t3].	some of the authors previously demonstrated a significant precocious serum t3 increase after 200 micrograms trh acute intravenous administration (trh test). reverse-t3 (rt3) is now known to interfere with t4 conversion to t3. we therefore compared spontaneously occurring to trh test-induced changes in t3 and rt3 serum levels within a group of four healthy women in fertile age. maximum rt3 increase during trh test did not differ significantly from the maximum spontaneous variation at the same tim ...	1982	6820291
[comparison between spontaneous changes in circulating triiodothyronine (t3 and reverse-t3) and those induced by acute intravenous administration of thyroliberin].	some of the authors had previously observed a slight-non significant decrease in t3 serum levels 10 minutes after trh intravenous administration. on the other hand, it is now well known that reverse t3 (rt3) inhibits t4 conversion to t3. we therefore investigated the changes in t3 and rt3 serum levels within the first ten minutes of a 200 micrograms trh test in a group of 10 healthy women in fertile age. no significant change in t3 was demonstrated. on the other hand, rt3 showed a significant-ye ...	1982	6820292
hyperthyroxinemia associated with high thyroxine binding to albumin in euthyroid subjects.	hyperthyroxinemia, and a high free-t4 index (calculated from t4 levels and t3 resin uptake), was observed in an euthyroid boy. thyroxine-binding globulin and prealbumin levels were normal. direct assay of free-t4 yielded a normal value. upon electrophoretic separation of a serum sample enriched with labeled t4 abnormal binding of t4 was detected in the albumin fraction. this binding was sensitive to barbital, and affected t3 to a lesser degree than t4. the excessive binding of t4 to albumin acco ...	1982	6820373
study of thyroid functions in protein energy malnutrition.	thyroid functions were studied in eight children suffering from pem. the assessment of thyroid functions were done by measuring serum t3 and t4 levels by radioimmunoassay. both t3 and t4 levels in serum were significantly (p less than 0.001) reduced in pem as compared to normal healthy children. these results suggest that thyroid functions are affected in pem. the impairment of such functions may possibly be due to a deficiency of protein or to a blockade in the incorporation of iodine into thyr ...	1982	6820931
serum thyroxine, triiodothyronine, and tsh levels and tsh release after trh in aging male and female rats.	serum levels of tsh, t3 and t4, pituitary responsiveness to trh, and t3-resin uptake were examined in aging male and female rats. despite normal serum tsh levels, serum t3 and t4 levels were significantly reduced in old male rats (19-26 months of age) when compared to young (120-150 days of age) and middle-aged males (12-1- months of age). in old female rats, serum tsh and t3 levels were not significantly (p greater than 0.05) different from those of young or middle-aged females. serum t4 levels ...	1982	6821309
radioimmunoassay of thyroxine and 3,3',5'-triiodothyronine (reverse t3) in human amniotic fluid.	measurement of amniotic fluid iodothyronine concentrations may enable antenatal detection of fetal thyroid abnormalities; however, the delineation of normal ranges is complicated by methodological problems associated with strong and highly variable protein-binding, and specificity of antisera. improved radioimmunoassays of thyroxine (t4) and 3,3',5-triiodothyronine (reverse t3, rt3) have been developed to overcome these problems. in normal pregnancy, mean rt3 concentrations at less than 17 weeks ...	1982	7053907
glucocorticoids decrease in conversion of thyroxine into 3, 5, 3'-tri-iodothyronine by isolated rat renal tubules.	1. the effect of glucocorticoids on the deiodination of thyroxine (t4) to 3,5,3'-tri-iodothyronine (t3) was studied in rat renal tubules prepared by collagenase digestion. 2. in short-term (6h) experiments, cortisol and dexamethasone inhibited the conversion of t4 into t3 at concentrations of 2 x 10-4 mol/l and 2 x 10-5 mol/l respectively. the inhibition by cortisol and dexamethasone was time dependent and was prevented by actinomycin d and progesterone, suggesting that the inhibition is mediate ...	1982	7053919
preferential inhibition of thyroxine and 3,5,3'-triiodothyronine formation by propylthiouracil and methylmercaptoimidazole in thyroid peroxidase-catalyzed iodination of thyroglobulin.	the present study was undertaken to determine whether the thioureylene antithyroid drugs propylthiouracil [6-propyl-2-thiouracil (ptu)] and methylmercaptoimidazole [1-methyl-2-mercaptoimidazole (mmi)] have a specific inhibitory effect on the thyroid peroxidase (tpo)-catalyzed conversion of diiodotyrosine to t4 (coupling reaction) independent of their well known inhibitory effect on peroxidase-catalyzed iodination. we have employed model incubation systems containing highly purified tpo to examin ...	1982	7053983
comprehensive kinetics of triiodothyronine production, distribution, and metabolism in blood and tissue pools of the rat using optimized blood-sampling protocols.	we have determined estimates for 24 physiological parameters of production, interpool transport, distribution, and metabolism of t3 in the major t3 pools of the unanesthetized male sprague-dawley rat, from blood-borne data and a comprehensive model and analysis of this system. most of these indices have previously been unavailable. whereas only 3% (2 ng/100 g bw) of the total body t3 pool (74 ng/100 g bw) is in plasma, the composite of slowly equilibrating (slow) tissue pools (e.g. muscle, skin, ...	1982	7053984
effect of sulfhydryl reagents on the conversion of thyroxine to 3,5,3'-triiodothyronine: direct action on thyroxine molecules.	sulfhydryl reagents are good stimulators of the enzymatic conversion of t4 to t3. previous studies have suggested that the underlying mechanism for this property is that these reagents may serve as a cofactor in the reaction, or they maintain the enzyme in its active reduced form. we examined another possibility, namely that sulfhydryl reagents affect t4 itself and hence increase t3 generation by the enzyme. the substrate t4 and sulfhydryl reagents dithiothreitol, mercaptoethanol, and reduced gl ...	1982	7053986
rat placenta is an active site of inner ring deiodination of thyroxine and 3,3',5-triiodothyronine.	inner ring deiodination of l-t4 and l-t3 by rat placental homogenates resulted in the generation of rt3 from t4 and 3,3'-diiodothyronine and 3'-monoiodothyronine from t3. dithiothreitol is required in the incubation medium. there was little or no detectable outer ring deiodination of t4 and t3. these findings suggest that placenta enzymatic inner ring monodeiodination of t4 and t3 could prevent the transplacental passage of t4 and t3 from dam to fetus. they also provide an explanation for our pr ...	1982	7053992
the significance of laryngeal edema following radiotherapy of carcinoma of the vocal cord.	laryngeal edema persisting for more than three months following radiotherapy developed in 38 of 247 (15.4%) patients irradiated for carcinoma of the vocal cord. in 17 (44.7%) of these patients, the laryngeal edema was associated with persistent or recurrent disease, although only 25.4% of the patients with uncontrolled disease had laryngeal edema. the incidence of laryngeal edema was 13.1% for t1 disease, 23.8% for t2, and 21.4% for t3 and t4 disease. it increased significantly with increase of ...	1982	7055780
effectiveness of analysis of free thyroxin concentration in serum for diagnosis of covert thyroid disease.	the indirect indices of free-thyroxin concentration (ft4) are of limited effectiveness in diagnosing covert (mild) thyroid disease. we compared measurements of ft4 and of normalized t4 (nt4, the effective thyroxin ratio) in a group of patients being treated for thyroid disease, most of whom were clinically euthyroid. although ft4 values correlated well with nt4, many of the patients (34% in one of the comparisons) had ft4 and nt4 values that gave different indications of thyroid status. a review ...	1982	7055946
[simultaneous thyroxin determination in thyrotropin (tsh) screening for congenital hypothyroidism (author's transl)].	a dried-blood screening test for demonstration of congenital hypothyroidism was developed using materials of a commercially available radioimmunoassay for estimation of thyroxin (t4) in serum. the method is characterised by simple performance and satisfactory precision (coefficient of variation 7.8-12.4%). performance of the test parallel to single determination of thyrotropin (tsh) instead of the usual tsh double determination is considered. diagnostic advantages of both methods can thus be com ...	1982	7056167
effect of thyroid hormones on human mononuclear leukocyte lysosomal acid lipase activity.	lysosomal acid lipase (lal), the enzyme which hydrolyzes lipoprotein cholesteryl esters, is under thyroid hormone regulation in experimental animals. to evaluate whether human lal is also under thyroid regulation, we measured mononuclear leukocyte lal activity in 31 hypothyroid, hyperthyroid, and euthyroid children under treatment. lal activity was positively correlated with serum t3 and serum t4 levels, and was significantly higher in hyperthyroid children than in those who were hypothyroid. in ...	1982	7056842
iodothyronine levels in human cerebrospinal fluid.	iodothyronines were measured by ria in concentrated human cerebrospinal fluid (csf). in measurements performed in one laboratory at a 4-fold concentration of csf, rt3 was detected in all 30 patients in whom the measurement was attempted and averaged 15.1 +/- 2.8 ng/dl (mean +/- se). in an independent laboratory, rt3 measurements at this 4-fold concentration were performed on 11 different samples and averaged 9.3 +/- 0.9 ng/dl, while at a 40-fold csf concentration, rt3 averaged 13.1 +/- 0.72 ng/d ...	1982	7056848
isolation of radioactive iodothyronines for kinetic studies: a comparison of two methods.	a method based on the principle of gel separation followed by antibody extraction (gsae) has been developed for isolation of radioactive thyroxine (t4), 3,5,3'-triiodothyronine (t3), 3,3'5'-triiodothyronine (rt3), 3,3'-diiodothyronine (3,3'-t2), 3',5'-diiodothyronine (3',5'-t2) and 3'monoiodothyronine (3'-t1) in serum. this method was used for the estimation of the metabolic clearance rate (mcr( of the iodothyronines using the single injection, non-compartmental approach, and was compared to the ...	1982	7058678
role of thyroxine in coordinate control of corticosterone and cbg in postnatal development.	the role of thyroxine (t4) in the ontogeny of serum corticosteroid-binding globulin (cbg) and corticosterone has been studied in the rat. daily injection of t4 (0.1 micrograms/g body wt) resulted in the precocious appearance of both cbg and corticosterone. a dose-response study revealed an increase in both cbg and corticosterone at thyroxine doses greater than 0.02 micrograms/g body wt. in propylthiouracil-induced hypothyroid pups, the developmental rise of both cbg and corticosterone was suppre ...	1982	7058886
high affinity 3,5,3'-l-triiodothyronine binding to synaptosomes in rat cerebral cortex.	studies were undertaken to define the existence of specific t3-binding sites in the synaptosomal fraction of rat cerebral cortex. development-related changes of the synaptosomal t3-binding sites were compared with those of nuclear t3 receptors in rat cerebral cortex. scatchard analysis was compatible with the existence of two sets of high affinity t3-binding sites: k1, with a mean (+/- se) apparent dissociation constant (kd) of 3.22 +/- 0.63 x 10(-11) m and a mean (+/- se) maximum binding capaci ...	1982	7060525
seasonal plasma t4 titers in the hibernating lizard cnemidophorus sexlineatus.		1982	7060932
analysis of the parameters relating to failures above the clavicles in patients treated by postoperative irradiation for squamous cell carcinomas of the oral cavity or oropharynx.	one hundred and two patients with squamous cell carcinoma of the oral cavity or oropharynx were treated from january 1955 through august 1976 with surgical excision followed by irradiation. twelve patients had t2 lesions and 90 had t3 or t4 lesions. failures above the clavicles were associated with disease present at the margins of resection, location of the recurrence close to the periphery, or outside of the irradiated portals. failure in the neck essentially were a result of no elective irrad ...	1982	7061253
stage iii and localized stage iv breast cancer: irradiation alone vs irradiation plus surgery.	one hundred forty-seven patients with non-inflammatory, stage iii and iv cancer were treated with irradiation alone (54 patients) or with a combination of irradiation and mastectomy (93 patients). in the t3 category, the local failure rate was 45% (5/11) for the irradiation alone patients vs 12% (3/25 for the irradiation plus surgery patients; in the t4 category these figures were 65% (28/43) vs 13% (9/68), respectively. corresponding local failure rates by size of primary tumor were 50% (2/4) v ...	1982	7061254
oxygen consumption and thyroid hormones in germfree mice fed glucose-amino acid liquid diet.	germfree rats and mice fed solid diets have previously been shown to consume less oxygen than their conventional counterparts. young adult germfree c3h/he mice how serum t3 concentrations comparable to those of conventional mice, but their serum t4 values are 10-15% lower. fed chemically defined liquid glucose-amino acid diets, germfree c3h mice use 27% more oxygen than comparable germfree mice fed a solid natural ingredient diet, and 12% more than conventional mice fed the solid diet. like germ ...	1982	7062149
thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion.	thyroid function was evaluated in the marshallese who were accidentally exposed to fallout-containing radioiodine isotopes in 1954. measurements of thyrotrophin (tsh, thyroid-stimulating hormone) levels and free thyroxine (t4) index (ft4i) have revealed that, among 86 persons exposed on rongelap and ailingnae atolls, 14 have shown evidence of thyroid hypofunction. this was first noted in some individuals about ten years after exposure. only two of these showed clinical evidence of hypothyroidism ...	1982	7062458
[diagnostic and therapeutic problems of nasopharyngeal carcinoma in childhood (author's transl)].	between 1974 and 1978 three children with a nasopharyngeal carcinoma (stages: t3n3mo, t4n2mo, t4n1mo) were treated with primary radiotherapy (tumor dose: 45-67 gy). local control was achieved in two children, one of these (t4 primarily) had a local relapse five months after diagnosis. only one of the three children had radiotherapy to the neck region. this child developed lung and mediastinal metastases with hypertrophic osteoarthropathy twelve months after diagnosis. in the other two children l ...	1982	7062686
modulation of estrogen-induced peroxidase activity in the rat uterus by thyroid hormones.	the effect of thyroid hormones, iodide, propylthiouracil and other thyroid-active agents on estrogen receptor concentration and on the induction of peroxidase in the immature rat uterus by estradiol (e2) was examined t3 (0.5 mg/kg) given daily for 6 days produced a large decrease in e2-induced uterine peroxidase but lowered only slightly the concentration of cytosolic or nuclear receptors in this organ. t4 also decreased the effect of e2 on uterine peroxidase induction and the inhibitory action ...	1982	7062739
nucleotide sequence of the bacteriophage t4 gene 57 and a deduced amino acid sequence.	a 693 basepair cloned fragment of bacteriophage t4 dna, which supports specifically growth of t4 amber mutants in gene 57, has been sequenced. a polypeptide can be deduced from this sequence, that is either 54 or 60 amino acids long depending which of two aug codons, 18 nucleotides apart, are used for initiation. the size of this deduced polypeptide is compatible with the size of a single polypeptide (based on polyacrylamide gel electrophoresis) synthesized in vivo in e. coli under the direction ...	1982	7063418
effect of high ambient temperature (35 degrees), and feed intake on plasma t4 levels in sheep.		1982	7063508
prolactin, estradiol, and thyroid hormones in umbilical cord blood of neonates with and without hyaline membrane disease: a study of 405 neonates from midpregnancy to term.	concentrations of prolactin (prl), estradiol (e2), thyroxine (t4), triiodothyronine (t3), and reverse t3 in umbilical cord blood were measured by radioimmunoassay in neonates with (n = 60) and in a control group without (n = 345) hyaline membrane disease. mean levels of all hormones assayed were not significantly different between the two groups at various stages of gestation. in the control group, gestational age correlated positively with prl and inversely with reverse t3, whereas birth weight ...	1982	7065044
emerging patterns of tampon use in the adolescent female: the impact of toxic shock syndrome.	from november 1980 through january 1981, we queried 714 post menarchal adolescents (ages 12 to 19) about menstrual product use at menarche (t1), during summer 1980 (t2), at last menstrual period (t3), and about intended product for next menstrual period (t4). the percentage of adolescents reporting use of tampons at each point in time were: t1, 3.1 per cent; t2, 24.1 per cent; t3 (following the media coverage of toxic shock syndrome [tss]), 19.3 per cent; and t4, 19.5 per cent. prior to tss cove ...	1982	7065334
reassessment of the human chorionic gonadotropin stimulation test in hypogonadal males.	eight normal and 17 hypogonadal males were injected with human chorionic gonadotropin (hcg). in normal males at 48 hr testosterone and estradiol became, respectively, 160% and 338% of basal values. in hypogonadal males at 48 hr testosterone and estradiol became respectively, 211% and 127% of basal values. no changes occurred in serum thyroid stimulating hormone (tsh), serum thyroxine (t4), and tri-iodothyronine (t3). the success of long-term therapy with hcg in five patients was predicted by the ...	1982	7065782
chemical hyperthyroidism: serum triiodothyronine levels in clinically euthyroid individuals treated with levothyroxine.	we have observed many patients treated with levothyroxine sodium who have elevated serum thyroxine (t4) levels but appear clinically euthyroid. such patients generally have normal serum triiodothyronine (t3) values. a retrospective review at the johns hopkins hospital, baltimore, comparing the correlation of t3 and t4 values in levothyroxine-treated patients with that in patients not so treated was carried out from 1977 to 1979. mean free thyroxine index (fti) value in 104 levothyroxine-treated ...	1982	7065792
effects of posture on the spread of spinal anaesthesia with isobaric 0.75% or 0.5% bupivacaine.	in a double-blind study the effects of posture on the spread of 3 ml of isobaric bupivacaine 5 and 7.5 mg ml-1 were compared after intrathecal injection in 40 patients undergoing orthopaedic surgery. three millilitre of isobaric bupivacaine 7.5 mg mg-1 administered with the patient in a sitting position during and for 2.5 min after injection produced the highest spread of analgesia (t4). horizontal posture, and the smaller dose in both positions, resulted in spread of analgesia to t7-8. motor bl ...	1982	7066128
protein metabolism in growing lambs given fresh ryegrass (lolium perenne)--clover (trifolium repens) pasture ad lib. 2. endocrine changes, glucose production, and their relationship to protein deposition and the partition of absorbed nutrients.	1. glucose metabolism and changes in the concentrations of several hormones in jugular plasma were measured in growing lambs fed on fresh pasture ad lib. one group of lambs acted as control while the second received a continuous abomasal infusion supplying 44 g sodium caseinate+0.5 g l-methionine/d. 2. hormone concentrations were determined by radioimmunoassay procedures and glucose irreversible loss measured from continuous infusion of d-[u-14c]glucose. 3. protein infusion increased plasma conc ...	1982	7066291
molecular mechanisms of binding and single-strand scission of deoxyribonucleic acid by the antitumor antibiotics saframycins a and c.	the quinone antitumor antibiotics saframycins a and c bind to duplex dna and g,c containing complementary oligodeoxyribonucleotides at phs below 5.5 via selective protonation of the antibiotics at the n-12 positions in an equilibrium process. this binding shows minor groove specificity to t4 dna for both antibiotics. saframycin a exhibits an additional mode of covalent binding to dna, which is reversible by heating, via an animal linkage with the nh2 group of guanine. covalent binding of saframy ...	1982	7066293
the influence on thyroid function of two iodine-containing radiological contrast media.	the aim of this study was to establish the effects of two iodine-containing radiological contrast media (ioxaglate and diatrizoate) on plasma iodide, thyroid hormones and tsh in a group of 20 subjects (8 females, 12 males). the following were evaluated two, eight and 30 days after administration of the drugs: plasma iodide, t4, t3, rt3, ft41, tsh before and after trh (250 micrograms iv). 131i uptake was measured before the media were given and 30 days afterwards. the results were compared at the ...	1982	7066635
effect of chronic lithium treatment on hypothalamic-pituitary regulation of thyroid function.	we have previously observed that chronic treatment with li causes a decrease in the goitrogenic response to iodine deficiency in rats. since this is likely to be mediated by an alteration of thyrotropin (tsh) secretion, we have investigated the hypothalamic and pituitary function of rats fed an iodine deficient li supplemented diet for 16 weeks. the li group had lower thyroid and pituitary weights than the corresponding control group. plasma thyroxine (t4) and 3,5,3'-triiodothyronine (t3) were l ...	1982	7068103
urinary free t4 and t3 in healthy infants and during noise exposure.	there is concern about noise exposure in the hospital environment and its effects on infants. stress reactions, however, are difficult to measure, especially in this age group. urinary t4 and t3 have proved to be equivalent to catecholamine determinations in helicopter pilots and in motion sickness. they represent the free fraction of thyroid hormones in serum. timed collections of urine were made in 78 healthy infants and in 43 infants exposed to standardized noise. t4 and t3 were determined by ...	1982	7068112
the effects of propranolol on thyroxine metabolism and triiodothyronines production in man.	the effects of propranolol on the turnover of thyroxine (t4), 3,5,3'-triiodothyronine (t3), and 3,3',5'-triiodothyronine (rt3) were determined by a noncompartmental analysis in seven normal men. fourteen normal subjects were treated with 0.2 mg t4 daily, and half of this group (seven) received in addition 80 mg propranolol daily. fifteen days of propranolol treatment did not alter serum t4 concentration or t4 turnover. however, it lowered serum t3 concentration from 173 to 102 ng/dl (p = 0.001); ...	1982	7068933
interrelation between the effects of ethanol and thyroid hormones on gluconeogenesis from alanine in perfused rat liver.	ethanol and thyroid hormones are among various factors that can alter hepatic gluconeogenesis, and the present study was done to determine the interrelation between the influence of ethanol and of t4 on glucose synthesis from alanine in isolated rat liver. with a sufficient supply of alanine, 20 mm ethanol enhanced glyconeogenesis nearly 60% in normal rat liver; higher ethanol concentrations, i.e., 40 or 80 mm, produced no further change in glucose synthesis. in contrast, 20, 40, or 80 mm ethano ...	1982	7069271
a case of membranous nephropathy associated with thyroid antigens.	a 54-year-old woman who had proteinuria due to stage ii membranous nephropathy is reported. she was treated with indomethacin for proteinuria and developed drug-induced hepatitis four months later. liver dysfunction gradually recovered, but hormonal studies revealed abrupt fall of t3 and t4 and concomitant elevation of tsh levels within a month. pathological findings of thyroid specimen and positive antithyroglobulin and antimicrosomal antibodies were compatible to chronic thyroiditis. in the se ...	1982	7069940
hypertension in hyperthyroidism: is there an epinephrine connection?	since hypertension seen in euthyroid subjects with depressed conjugated epinephrine and moderately elevated free epinephrine in plasma is strikingly similar to the beta-hyperadrenergic, high-output hypertension seen in some hyperthyroid patients, the possibility is discussed that thyroid action on sulfoconjugation could affect the biodisposability of endogenous free e and so indirectly the manifestation of sympathetic hyperactivity. there is only circumstantial evidence for such a possibility at ...	1982	7070222
cardiac function in mild and severe primary hypothyroidism.	one hundred patients with mild to severe primary hypothyroidism have been analyzed for abnormalities in left ventricular performance utilizing noninvasive techniques. these studies have revealed significant abnormalities in cardiac function which correlated inversely with serum t4 levels. the abnormalities in cardiac function were completely reversible with thyroid hormone therapy. even in patients with mild subclinical hypothyroidism, significant changes in left ventricular performance were ach ...	1982	7070224
interactions of iron deficiency, anemia, and thyroid hormone levels in response of rats to cold exposure.	we have earlier shown that iron-deficient rats have increased urinary norepinephrine (ne) excretion. they also have an exaggerated rise in urinary ne when placed in the cold, a stimulus known to cause increased ne excretion in normal rats. nonetheless, they fall to maintain body temperature. we have now examined the thyroidal response to cold in iron-deficient rats. as others have shown, control rats had a rise in plasma levels of thyroxine (t4) and triiodothyronine (t3) soon after entering the ...	1982	7070226
[determination of free thyroxine by radioimmunoassay-determination of free thyroxine by amerlex free t4 ria kit (author's transl)].		1982	7071386
[determination of free thyroxine by radioimmunoassay-comparison of free t4 values by different free t4 kits (author's transl)].		1982	7071387
tsh and thyroxine in cord blood of subjects from an endemic area.	thyroxine (t4) and tsh were assayed in the triplet: maternal venous blood at delivery (m), cord blood (c) and total capillary dry spot blood of the corresponding children 4 - 5 days postpartum (nb). fifty-four triplets in all (spontaneous deliveries, full term infants from the cîmpulung endemic goiter area) were thus determined by sampling out the native families. the controls were 10 triplets from bucharest, a non-endemic goiter area. a group of 31 pregnant women from the endemic area who have ...	1982	7071505
follicular reconstruction and hormone production by human adenomatous goiter cells in culture.	morphological and functional properties of dispersed cells of human adenomatous goiter and those of the thyroid tissue adjacent to and distant from the nodular lesion (normal control) were investigated. in the presence of tsh, reconstructive arrangement of adenomatous goiter cells into a three-dimensional follicular structure occurred in a similar manner to that of normal controls. an addition of thyrotropin (tsh) to culture resulted in the secretion of thyroid hormones in control cells, but ade ...	1982	7071845
[elective radiotherapy in breast carcinoma].	from march 1972 to november 1979 a total of 157 patients with stage i to iii primary breast cancers have been irradiated after segmental resection (12 cases), tilectomy (89 cases) or biopsy (56 cases). complete local control was achieved in all stage i lesions, in 97% of stage ii lesions and in 68% of stage iii lesions. non recurrence has been observed in patients previously operated by segmental resections, while local failures occurred in 6/89 and in 16/56 patients operated by tilectomy or bio ...	1982	7071949
inhibition of thyroidal iodine release by oestrogens in euthyroid subjects.	the effects of oestrogens on the release of thyroxine iodide (t4 i) and non-t4 i by the thyroid gland of 6 normal subjects and 3 thyrotrophin (tsh)-treated patients with hypopituitarism were assessed before, during and after treatment with 25 mg of dienoestrol (glaxo lab.), orally, daily, during 8 days. each subject received an iv injection of 150 microci of 125i followed 6 days later by an iv injection of 75 microci of [131i]t4. blood samples and collections of urine were obtained every 12 h. f ...	1982	7072447
maturation of renal and hepatic monodeiodination of thyroxine to triiodothyronine and post-natal changes of serum thyroid hormones in young rats.	maturational changes of renal and hepatic 5'-monodeiodination of thyroxine (t4) and post-natal changes of serum thyroid hormone levels were investigated in young rats under 35 days of age. renal t3 generation in the 1-day-old rats was low, rose progressively to a level of more than 200% of the adult rats on days 21 and 28 and declined thereafter. in contrast, hepatic t3 generation increased from an initial low activity to a plateau after 7 days of age, which was 1 1/2 times higher than that of a ...	1982	7072451
thyroid hormone dependent nuclear proteins from rat liver.	two nuclear proteins from rat liver were shown to be dependent on thyroid hormones. these proteins were present in the nucleosol or nucleoplasmic fraction, and were extracted from the nuclei with 0.15 m nacl at ph8. after thyroidectomy, a 120000-mr polypeptide decreased in concentration to levels below 10% of normal control rats and another polypeptide of 81000-mr was increased. treatment with t4 at physiological replacement doses for several days restored the levels of both proteins to normal. ...	1982	7072454
effect of posttraumatic epidural analgesia on the cortisol and hyperglycaemic response to surgery.	plasma cortisol and glucose were measured in 36 patients undergoing abdominal hysterectomy under either general anaesthesia (group i), epidural analgesia (t4-s5) effective before surgery (group ii) or general anaesthesia plus epidural analgesia (t4-s5) effective from 30 min after initiation of surgery. the results confirmed that epidural analgesia effective before skin incision (group ii) prevented the normal per-and postoperative increase in plasma cortisol and glucose. patients receiving postt ...	1982	7072474
defective thyroid ontogenesis in fetal hypothyroid (hyt/hyt) mice.	thyroid glands of fetal hypothyroid (hyt/hyt) mice were studied to determine the effects of the mutant gene during embryogenesis. comparisons of mutant and normal thyroids were made with respect to morphology, iodine-concentrating ability, and glandular thyroxine (t4) content at day 18 of gestation. fetal hyt/hyt thyroid tissue was properly located, but incompletely differentiated. the mutant thyroid was characterized microscopically by small, poorly developed follicles with colloid diminished i ...	1982	7072984
comparison of amerlex, nml, and ames total thyroxine and triiodothyronine radioimmunoassay kits.	an evaluation of the amerlex system for determination of total thyroxine (t4) and total triiodothyronine (t3) is described. the within- and between-batch precisions were acceptable, and analyses of quality control material and linearity studies demonstrated good accuracy at the clinical decision levels. the correlations obtained with nml and ames t4 and t3 kit methods were highly significant. the amerlex t4 and t3 methods are rapid, technically simple, and, coupled with excellent precision and a ...	1982	7073210
disappearance rate of endogenously radioiodinated thyroglobulin and thyroxine after radioiodine treatment.	endogenously radioiodinated thyroglobulin (tg) and thyroxine (t4), in the circulation following, therapeutic doses of radioiodine were studied in five patients with differentiated thyroid carcinoma. radioactive serum was fractionated on a sephadex g-200 and the various radioactive peaks thus obtained were analyzed for their biochemical and immunologic characteristics using precipitation with trichloroacetic acid (tca) and antithyroglobulin antibody extraction with acidified n-butanol and electro ...	1982	7074544
an improved method for the radioimmunoassay of free-thyroxine in serum dialysates.	a convenient, sensitive radioimmunoassay of free thyroxine in serum dialysates is described. the method utilizes a solid phase separation system (pre-formed double antibody) and a relatively short incubation period (220 min) with a staggered addition of tracer. blanks were low and consistent. the normal range for non-pregnant euthyroid samples (n=59) was 11-23 pmol/l. third trimester pregnancy samples were mostly within the normal range but at the lower end. patients on t4 replacement showed a m ...	1982	7074970
effects of thyroid hormone on some uterine responses to estrogen.	uterine edema induced by 0.1 microgram 17 beta-estradiol (e2)/100 g bw, as well as uterine eosinophilia induced by 0.01, 0.1, 1, 10, and 30 micrograms e2/100 g bw, decrease in the presence of 20 micrograms t3 or t4/100 g bw in the immature rat. estrogen binding by uterine eosinophils and the number of eosinophils in the blood also decrease with t3 or t4, suggesting an explanation for the findings in the uterus. thyroid hormones alone or in the presence of 0.001, 0.01, 0.1 and 1 microgram e2/100 ...	1982	7075537
specific nuclear binding sites of triiodothyronine and reverse triiodothyronine in rat and pork liver: similarities and discrepancies.	the specific binding of [125i]t3 and [125i]rt3 to nuclear extracts of rat and pork liver was studied. the ka values of the binding of t3 and rt3 to nuclear extracts were similar (0.65 +/- 0.12 vs. 0.68 +/- 0.10 x 10(9) m-1; p = ns), but the maximal binding capacity for t3 was smaller than that for rt3 (333 +/- 36 vs. 1209 +/- 338 fmol/mg dna; p less than 0.05). the amount of nonradioactive t4 required to cause a 50% displacement of [125i]t3 from the nuclear binding sites was, on a molar basis, 2 ...	1982	7075548
outer and inner ring monodeiodination of thyroxine by dog thyroid and liver: a comparative study using a particulate cell fraction.	in previous studies using perfused dog thyroids we have found evidence for a modulation of thyroid secretion by intrathyroidal thyroxine deiodinases. the purpose of the present study was to examine in detail the in vitro characteristics of thyroidal 5- and 5'-deiodinases of t4 and to make a comparison to t4 deiodinases from liver tissue. the sources of deiondinases were crude microsomal fractions prepared from thyroid and liver tissues obtained from the same dogs. deiodinases from the two tissue ...	1982	7075551
affinity purification of bacteriophage t4 lysozyme free of nuclease.		1982	7075770
gastric acid secretion, serum gastrin and parietal cell histology in hyperthyroidism.	a decrease in mao by gastrin stimulation was observed in 13 of 20 hyperthyroid patients. five of these 13 cases had achlorhydria. the decrease in gastric acid secretion had no relation to the duration of symptoms, serum t3 and t4 levels, serum antithyroglobulin antibody levels and serum antithyroid microsomal antibody levels. gastroscopy with biopsy was performed in 17 cases. in patients with achlorhydria, macroscopic and histological atrophy was not observed in the body, and parietal cells were ...	1982	7075932
gastric acid secretion, serum gastrin and parietal cell histology in rat hyperthyroidism.	experimental hyperthyroidism was produced in rats by thyroxin injection, and changes in gastric acid secretion and serum gastrin level were determined to analyze the relation between these changes and hyperthyroidism. administration of thyroxin to two groups of rats-20 micrograms per 100 g of body weight for 20 days and 75 micrograms for 7 days-brought about significant increases in serum t3 level, gastric ph and serum gastrin level. an increase in gastric ph took place later than that in serum ...	1982	7075933
the extrathyroidal effect of d,l-propranolol on 3,3',5'-triiodothyronine, 3',5'-diiodothyronine, 3,3'-diiodothyronine, and 3'-monoiodothyronine kinetics.	the effect of d,l-propranolol (80 mg daily) on the peripheral monodeiodination of rt3, 3',5'-diiodothyronine (3',5'-t2), 3,3'-diiodothyronine (3,3'-t2), and 3'-monoiodothyronine (3'-t1) was studied in seven out-patients with severe pretreatment hypothyroidism. the patients were maintained euthyroid on a constant l-t4 replacement therapy. a bolus injection technique was used; mcr, production rate (pr), and conversion rate were determined using a noncompartmental kinetic model. during d,l-proprano ...	1982	7076792
the relationship between serum triiodothyronine and thyrotropin during systemic illness.	the reported failure of serum tsh to rise in response to the low serum t3 of severe systemic illness may be due to the known stress inhibition of tsh secretion. we therefore measured tsh and total and free thyroid hormones during the course of recovery from severe illness. during recovery, tsh increased at a time when t3 was rising but still below normal (mean tsh during recovery, 6.5 +/- 0.8 sem microu/ml, n = 41 vs. normal, 2.5 +/- 0.2 sem microu/ml; n = 31; p less than 0.001), tsh concentrati ...	1982	7076798
transient hypothyroidism associated with short gut syndrome.	two consecutive short gut babies with a residual small intestinal length of 44 and 46 cm, respectively, were managed initially by total parenteral nutrition and oral feedings begun around the fifth week postoperatively. uncontrollable diarrhea, malabsorption, and failure to thrive made the early management of these babies a difficult problem. the two infants developed clinical features of hypothyroidism at the age of 4 and 6 mo, respectively. hypothyroxinemia was confirmed by repeated detection ...	1982	7077472
amino acid substitutions far from the active site of bacteriophage t4 lysozyme reduce catalytic activity and suggest that the c-terminal lobe of the enzyme participates in substrate binding.		1982	7077670
visualization of the dna thread packing within bacteriophage t4 heads.		1982	7077745
[measurement of free thyroxine concentration employing sold-supported anti-t4 antibody (author's transl)].		1982	7077876
[fundamental and clinical evaluation of free t4 a kit (gamma coat ft4) with radioimmunoassay (author's transl)].		1982	7077879
[hypophyseo-thyroid system in stress stenocardia and myocardial infarct with favorable and unfavorable course].	the condition of the hypophyseal-thyroid system in patients with angina of effort and in those with myocardial infarction in the acute stage was studied by determining the content in the blood of the thyrotropic hormone (tth), thyroxin (t4), and triiodthyronine and 2-hour iodine uptake by the thyroid. it was found that the functional condition of the hypophyseal-thyroid system in patients with angina of effort differs essentially from that in patients with myocardial infarction. the behavior of ...	1982	7077934
nucleotide sequence of a spinach chloroplast proline trna.	the nucleotide sequence of a spinach chloroplast proline trna (sp. chl. trnapro) has been determined. this trna shows more overall homology to phage t4 proline trna (61% homology) than to eukaryotic proline trnas (53% homology) or mitochondrial proline trnas (36-49% homology). sp. chl. trnapro, like all other chloroplast trnas sequenced, contains a methylated gg sequence in the dihyrouridine loop and lacks unusual structural features which have been found in many mitochondrial trnas.	1982	7079185
[direct determination of free thyroxine in two simultaneous radioimmunoassays with different test principles: validity of test research derived from an area of marked iodine deficiency (author's transl)].	serum ft4 was measured simultaneously by the commercial ft4 kits of amersham-buchler and corning medical in 4 groups with defined thyroid function as follows: 57 euthyroid subjects with and without goitre, 27 patients on t4 supplementation, 12 subjects on oral contraceptives and 26 subclinically hyperthyroid patients. all patients underwent physical examination, thyroid scintigraphy and additional in-vitro tests (total thyroxine t4, total triiodothyronine t3 and trh/tsh assay). both assays gener ...	1982	7079187
[assay of protein and thyroid hormone concentrations in hemofiltrate (author's transl)].	to assess protein and thyroid hormone loss during hemofiltration estimation of protein and thyroid hormone concentrations in the hemofiltrate were carried out. the protein loss during one week amounted to 4-6 g. weekly loss of t4 was about 1,5 microgram, that of t4 0,5 microgram. these quantities are negligible and of no clinical relevance. therefore substitutions of protein loss by albumin or thyroid hormones do not seem to be required in patients undergoing hemofiltration.	1982	7079188
thyroid activity during hepatocarcinogenesis by n-2-fluorenylacetamide in the male rat.	during chemical hepatocarcinogenesis by n-2-fluorenylacetamide, the hormonal status of male sprague dawley rats is modified. the histological study of the thyroid gland demonstrates a decreased activity evidenced by an augmentation of the follicle size and a reduced size of follicular epithelium. the level of t3 and t4 reflects in part this decreased activity. comparison with female rats treated in the same conditions shows an opposite effect of n-2-fluorenylacetamide. indeed in the female, the ...	1982	7079578
adenoma of the human pituitary producing growth hormone and thyrotropin. a histologic, immunocytologic and fine-structural study.	a pituitary adenoma removed by surgery from a 22-year-old man was studied by histology, immunocytology, transmission electron microscopy and immunoelectron microscopy. clinically, the patient had acromegaly and euthyroidism with elevated blood gh concentrations. blood tsh and t4 levels were within the normal range. histologically, the adenoma was chromophobic and exhibited no pas, lead hematoxylin, aldehyde thionin or grimelius silver positivity. by the immunoperoxidase technique gh, beta-tsh an ...	1982	7080435
reversal of t4 rna ligase.	unexpected products detected in oligoribonucleotide synthesis reactions catalyzed by t4 rna ligase are shown to be a result of a partial reversal of the enzyme reaction. a transfer assay for the reversal of the third step in the rna ligase reaction mechanism and an exchange assay for the reversal of both the second and third steps are described. reversal is confirmed by the formation of the expected covalent intermediates, adenylylated donor and adenylyl ligase, from a reaction containing 5'-amp ...	1982	7082652
a bacteriophage-induced 5-methyldeoxycytidine 5'-monophosphate kinase.	bacteriophage xp-12-infected xanthomonas oryzae have been found to be a source of a kinase preparation which converts m5dcmp to m5dcdp and then to m5dctp using atp as the phosphate donor. optimal formation of the triphosphate required the presence of creatine phosphate and creatine kinase. in the presence of dgtp, dttp and datp, escherichia coli dna polymerase i and t4 dna polymerase catalyzed the incorporation of m5dctp into dna just as efficiently as that of dctp. neither dtmp nor dcmp served ...	1982	7082669
adrenomedullary ornithine decarboxylase activity: its use in biochemical mapping of the origins of the splanchnic nerve in the rat.	the activity of ornithine decarboxylase in the adrenal medulla of the rat can be induced transsynaptically by the repeated administration of apomorphine. unilateral section of one to four ventral spinal cord roots from t4 to t12 partially prevents this effects. interruption of the intercostal nerves (t7--t13), with preservation of the autonomic innervation of the adrenal medulla, does not produce any alteration in the response of the medullary odc to apo in the operated side as compared to the i ...	1982	7083002
urinary cea for prediction of survival time and recurrence in bladder cancer.	the prognostic information from carcinoembryonic antigen was evaluated in bacteria-free urines of patients with bladder carcinoma. patients with elevated (greater than or equal to 30 ng/ml) u-cea had a poorer relative and symptom-free survival than patients with initial u-cea below 30 ng/ml. patients in whom u-cea decreased from before to after radiation treatment had a better survival rate than patients with increasing u-cea. these findings were most significant in cases with large (t3 + t4) tu ...	1982	7083117
pharmacokinetic significance of serum reverse t3 levels during amiodarone treatment: a potential method for monitoring chronic drug therapy.	we studied the antiarrhythmic effects of amiodarone, 600-1400 mg/day, in 18 patients with refractory arrhythmias, and related to drug efficacy and side effects to serum levels of t4, reverse t3 (rt3) and the qtc interval. in the 11 patients with ventricular arrhythmias, premature complexes were reduced by 90-98%, and complex ectopy and runs of ventricular tachycardia were abolished; in the seven patients with paroxysmal atrial flutter, there were no recurrences on stable drug therapy. the qtc le ...	1982	7083508
comprehensive kinetics of thyroxine distribution and metabolism in blood and tissue pools of the rat from only six blood samples: dominance of large, slowly exchanging tissue pools.	we have estimated 24 physiological parameters of production, interpool transport, distribution, and metabolism of t4 in the major t4 pools of the unanesthetized male sprague-dawley rat from six optimally timed blood samples (at 1, 5, 23, 115, 465, 1440 min) and a comprehensive model and analysis. despite 10-fold lower concentrations of t4 reported in tissues that exchange t4 with plasma at a slow rate (e.g. skeletal muscle) compared with rapidly exchanging tissues like liver and kidney, the comp ...	1982	7084106