Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| simultaneously increased expression of microrna-155 and suppressor of cytokine signaling 1 (socs1) gene in the peripheral blood mononuclear cells of patients with primary sjögren's syndrome. | the microrna-155 (mir-155) is regarded as a central modulator of t-cell responses and could be a potential therapeutic target for certain inflammatory diseases. in our present study we analyzed the expression rate of mir-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (socs1) in primary sjögren's syndrome (pss). | 2015 | 26620207 |
| hpv infection, but not ebv or hhv-8 infection, is associated with salivary gland tumours. | benign and malignant salivary gland tumours are clinically heterogeneous and show different histology. little is known about the role of human herpes virus 8 (hhv-8), epstein-barr virus (ebv), and human papillomavirus (hpv) infection in salivary gland neoplasms. we investigated the presence of the three viruses in formalin-fixed, paraffin-embedded tissue samples in a cohort of 200 different salivary gland tumours. we performed ebv-lmp-1 and hhv-8 and p16 immunohistochemistry, a specific chip bas ... | 2015 | 26618178 |
| a case of gastric cancer with heterogeneous components of eb virus (+)/tp53 (+) and eb virus (-)/tp53 (-). | epstein-barr virus (ebv)-associated gastric adenocarcinoma is a histological subtype of gastric adenocarcinoma, in which all of the carcinoma cells are basically positive for ebv-encoded small rna (eber) by in situ hybridization. although its typical histology has some overlap with gastric carcinoma with lymphoid stroma, absence of massive lymphoid infiltrate is sometimes observed either in whole or in part. ebv-associated adenocarcinoma is one of the four representative molecular pathological s ... | 2015 | 26617924 |
| primary mucosal cd30-positive t-cell lymphoproliferative disorders of the head and neck rarely involving epiglottis: clinicopathological, immunohistomchemical and genetic features of a case. | a case of primary mucosal cd30-positive t-cell lymphoproliferative disorder of the head and neck rarely involving epiglottis in a 59-year-old male was reported. histologically, the ulcerative mucosa was affected by sheets of mixed inflammatory infiltration, with scattered large atypical lymphoid cells arranging in an individual or small clusters with focal epidermotropism. immunohistochemically, tumor cells were uniformly immunoreactive to antibodies against cd2, cd3, cd7, cd43, cd4, tia-1, with ... | 2015 | 26617911 |
| prognostic value of trop2 in human nasopharyngeal carcinoma. | there is increasing evidence demonstrating the role of human trophoblast cell surface antigen 2 (trop2) in cancer development and progression. however, their prognostic value in epstein-barr virus (ebv) associated nasopharyngeal carcinoma (npc) remains to be elucidated. | 2015 | 26617817 |
| genotypic detection of epstein barr virus in pediatric transplant recipients from india. | to determine the rate of occurrence and genotypes of epstein-barr virus (ebv) among pediatric renal and liver transplants recipients. | 2015 | 26615341 |
| seroprevalence of anti-ebv igg among various age groups from khon kaen province, thailand. | epstein-barr virus (ebv) is an extremely common herpesvirus that may cause asymptomatic infection or various diseases, including infectious mononucleosis, certain lymphoproliferative diseases and several types of neoplasms. vaccine development is an important strategy to reduce the burden of ebv-associated diseases and the timing of vaccinations should be before primary infection occurs. in the past, more than 90% of thai children were infected with ebv in early childhood. now, due to the improv ... | 2015 | 26625765 |
| the incubation period of primary epstein-barr virus infection: viral dynamics and immunologic events. | epstein-barr virus (ebv) is a human herpesvirus that causes acute infectious mononucleosis and is associated with cancer and autoimmune disease. while many studies have been performed examining acute disease in adults following primary infection, little is known about the virological and immunological events during ebv's lengthy 6 week incubation period owing to the challenge of collecting samples from this stage of infection. we conducted a prospective study in college students with special emp ... | 2015 | 26624012 |
| adult systemic epstein-barr virus-positive t-cell lymphoproliferative disease: a case report. | systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disease (ebv(+) t-lpd) occurs mainly in asia and south america and is extremely rare in adults. the disease is characterized by a clonal proliferation of ebv-infected t cells with a cytotoxic immunophenotype and is associated with a poor clinical outcome and can be life-threatening. the majority of the patients have evidence of systemic disease, often with lymph node, liver and spleen involvement. the present study describes a ... | 2015 | 26622433 |
| fever, dry cough and exertional dyspnea: pulmonary lymphomatoid granulomatosis masquerading as pneumonia, granulomatosis with polyangiitis and infectious mononucleosis. | lymphomatoid granulomatosis (lyg) is a rare epstein-barr virus-associated lymphoproliferative disorder. the disease lacks specific clinical and radiological manifestations, which may delay a definitive diagnosis. we report the case of a 39-year-old man with pulmonary lyg who presented to a hospital after experiencing three months of fever, weight loss, dry cough and exertional dyspnea. he was initially misdiagnosed with pneumonia, granulomatosis with polyangiitis and infectious mononucleosis due ... | 2015 | 26631890 |
| epstein-barr virus-associated lymphoproliferative disorders: experimental and clinical developments. | epstein-barr virus (ebv), the first human virus related to oncogenesis, was initially identified in a burkitt lymphoma cell line in 1964. ebv infects over 90% of the world's population. most infected people maintain an asymptomatic but persistent ebv infection lifelong. however, in some individuals, ebv infection has been involved in the development of cancer and autoimmune disease. nowadays, oncogenic potential of ebv has been intensively studied in a wide range of human neoplasms, including ho ... | 2015 | 26628948 |
| gammaherpesvirus infection of human neuronal cells. | gammaherpesviruses human herpesvirus 4 (hhv4) and hhv8 are two prominent members of the herpesvirus family associated with a number of human cancers. hhv4, also known as epstein-barr virus (ebv), a ubiquitous gammaherpesvirus prevalent in 90 to 95% of the human population, is clinically associated with various neurological diseases such as primary central nervous system lymphoma, multiple sclerosis, alzheimer's disease, cerebellar ataxia, and encephalitis. however, the possibility that ebv and k ... | 2015 | 26628726 |
| the role of epstein-barr virus lmp-1 immunohistochemical staining in childhood hodgkin lymphoma. | there are a few published studies about prognostic markers of epstein-b virus (ebv) related to outcomes in pediatric hodgkin lymphoma (hl). | 2015 | 26635935 |
| comparative mutagenesis of pseudorabies virus and epstein-barr virus gh identifies a structural determinant within domain iii of gh required for surface expression and entry function. | herpesviruses infect cells using the conserved core fusion machinery composed of glycoprotein b (gb) and gh/gl. the gh/gl complex plays an essential but still poorly characterized role in membrane fusion and cell tropism. our previous studies demonstrated that the conserved disulfide bond (db) c278/c335 in domain ii (d-ii) of epstein-barr virus (ebv) gh has an epithelial cell-specific function, whereas the interface of d-ii/d-iii is involved in formation of the b cell entry complex by binding to ... | 2015 | 26656711 |
| a meta-analysis of interaction between epstein-barr virus and hla-drb1*1501 on risk of multiple sclerosis. | infection with epstein-barr virus (ebv) and hla-drb1*1501-positivity is a risk factor for multiple sclerosis (ms), but whether an interaction between these two factors causes ms is unclear. we therefore conducted a meta-analysis on the effect of the interaction between hla-drb1*1501 and ebv infection on ms. searches of pubmed, web of science, china national knowledge infrastructure (cnki), and the wanfan databases through february 2015 yielded 5 studies that met the criteria for inclusion in the ... | 2015 | 26656273 |
| secondary neuroendocrine tumor after allogeneic bone marrow transplantation. | here we report a case of aggressive neuroendocrine tumor (net), which is an extremely rare secondary solid tumor that occurs after allogeneic hematopoietic cell transplantation (allo-hsct). a patient with chronic active epstein-barr virus infection received allo-hsct from an hla-dr two allele-mismatched unrelated donor. four years later, he developed net with multiple metastases. he received thoraco-abdominal irradiation as a conditioning regimen, and developed repeated episodes of intestinal gr ... | 2015 | 26711919 |
| [infection status and prognostic significance analysis of epstein-barr virus in 207 cases with newly diagnosed hodgkin's lymphoma]. | to evaluate the epstein barr virus (ebv) positive rate in untreated hodgkin's lymphoma (hl) and investigate the prognostic significance of ebv status. | 2015 | 26711606 |
| [cellular immune therapy for epstein-barr virus infection after hematopoietic stem cell transplantation]. | hematopoietic stem cell transplantation is an effective method for treatment of hematologic malignancies. due to the use of immunosuppressive agents and a long time of immune restoration after transplantation, the incidence of virus infection is high. epstein-barr virus (ebv) infection is a common viral infection after transplantation. in spite of the low incidence of post transplantation lymphoproliferative disorder (ptld) caused by ebv, this disease is characte-rized by rapid progression and h ... | 2015 | 26708907 |
| [clinicopathologic analysis of angioimmunoblastic t-cell lymphoma with hodgkin/reed-sternberg-like cells]. | to study the clinicopathologic features and pathologic diagnosis and differential diagnosis of angioimmunoblastic t-cell lymphoma with hrs-like cells. | 2015 | 26705178 |
| [epstein-barr virus-associated inflammatory pseudotumour of kidney]. | 2015 | 26704837 | |
| pediatric advanced stage nasopharyngeal carcinoma - case report. | nasopharyngeal carcinoma is an extremely rare pediatric malignancy predominantly occurring in adolescent males. its multifactorial pathogenesis is most strongly associated with the exposure to epstein-barr virus in genetically susceptible hosts. in younger patients, more aggressive biological behavior has been observed, although the overall survival is better compared to adults. due to its rarity and nonspecific clinical presentation, the diagnosis in children is often delayed and misinterpreted ... | 2015 | 26702913 |
| identification and functional analysis of the bim interactome; new clues on its possible involvement in epstein-barr virus-associated diseases. | epigenetic deregulation is a common feature in the pathogenesis of epstein-barr virus (ebv)-related lymphomas and carcinomas. previous studies have demonstrated a strong association between ebv latency in b-cells and epigenetic silencing of the tumor suppressor gene bim. this study aimed to the construction and functional analysis of the bim interactome in order to identify novel host genes that may be targeted by ebv. fifty-nine unique interactors were found to compose the bim gene network. ont ... | 2015 | 26702402 |
| epstein-barr virus-encoded lmp1 increases mir-155 expression, which promotes radioresistance of nasopharyngeal carcinoma via suppressing ubqln1. | epstein-barr virus (ebv)-encoded latent membrane protein (lmp1) can drive aberrant expression of mir-155 in nasopharyngeal carcinoma (npc). in this study, we investigated the regulation of mir-155 expression over ubqln1 and studied their effects on radio-sensitivity of npc. | 2015 | 26698246 |
| the epstein-barr virus bart mirna cluster of the m81 strain modulates multiple functions in primary b cells. | the epstein-barr virus (ebv) is a b lymphotropic virus that infects the majority of the human population. all ebv strains transform b lymphocytes, but some strains, such as m81, also induce spontaneous virus replication. ebv encodes 22 micrornas (mirnas) that form a cluster within the bart region of the virus and have been previously been found to stimulate tumor cell growth. here we describe their functions in b cells infected by m81. we found that the bart mirnas are downregulated in replicati ... | 2015 | 26694854 |
| non-human cancers in aids patients. | neoplasms are more frequent in hiv-positive persons than in non-infected individuals. the incidence of malignancies associated to oncoviruses increases with low cd4 counts in hiv carriers. this is the case for kaposi sarcoma, castleman disease or effusive cavity lymphomas due to hhv-8, anorectal or cervical cancer due to human papillomavirus, and burkitt lymphoma or large b-cell lymphoma due to epstein-barr virus. | 2015 | 26690493 |
| the impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy. | the impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (npc) patients who received intensity-modulated radiotherapy (imrt) was evaluated. | 2015 | 26675209 |
| a single nucleotide polymorphism in the epstein-barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma. | epstein-barr virus (ebv) commonly infects the general population and has been associated with nasopharyngeal carcinoma (npc), which has a high incidence in certain regions. this study aimed to address how ebv variations contribute to the risk of npc. | 2015 | 26675171 |
| accumulation mechanisms of cd4(+)cd25(+)foxp3(+) regulatory t cells in ebv-associated gastric carcinoma. | approximately 10% of gastric carcinomas are associated with epstein-barr virus (ebv) and are defined as ebv-associated gastric carcinomas (ebvagcs). ebvagcs are known to be accompanied by massive cd8(+) cytotoxic t cell (ctl) infiltration; however, adoptive cellular immunotherapy based on ebv-specific cd8(+) ctls has been explored with limited success. because regulatory t cells (tregs) are regarded as a critical hurdle in anti-tumour immunity, we assessed the distribution of tregs in 45 cases o ... | 2015 | 26673957 |
| plasma epstein-barr viral deoxyribonucleic acid predicts worse outcomes in pediatric nonmetastatic nasopharyngeal carcinoma patients: an observational study of 89 cases in an endemic area. | to evaluate the clinical significance of pretreatment levels of plasma epstein-barr virus dna (pebv dna) on prognoses in pediatric nasopharyngeal carcinoma (npc) patients. eighty-nine patients aged 21 years old or younger with nonmetastatic npc were evaluated to determine the effect of pebv dna levels on progression-free survival (pfs), distant metastasis-free survival (dmfs), and overall survival (os). survival probabilities in patient groups that were segregated by clinical stage or pebv dna l ... | 2015 | 26683909 |
| risk stratification on the basis of deauville score on pet-ct and the presence of epstein-barr virus dna after completion of primary treatment for extranodal natural killer/t-cell lymphoma, nasal type: a multicentre, retrospective analysis. | assessment of tumour viability after treatment is essential for prediction of treatment failure in patients with extranodal natural killer/t-cell lymphoma (enktl). we aimed to assess the use of the post-treatment deauville score on pet-ct and epstein-barr virus dna as a predictor of residual tumour, to establish the risk of treatment failure in patients with newly diagnosed enktl. | 2015 | 26687611 |
| preemptive therapy with ganciclovir and cytomegalovirus hyperimmune globulin delayed the onset of epstein-barr virus-associated post-transplant acute limbic encephalitis. | 2015 | 26671100 | |
| sudden onset unilateral sensorineural hearing loss after rabies vaccination. | a 33-year-old man developed profound sudden onset right-sided hearing loss with tinnitus and vertigo, within 24 h of pretravel rabies vaccination. there was no history of upper respiratory tract infection, systemic illness, ototoxic medication or trauma, and normal otoscopic examination. pure tone audiograms (pta) demonstrated right-sided sensorineural hearing loss (thresholds 90-100 db) and normal left-sided hearing. mri internal acoustic meatus, viral serology (hepatitis b, c, hiv and cytomega ... | 2015 | 26670892 |
| [rs3pe syndrome associated with senile epstein-barr virus-positive diffuse large b cell lymphoma of a patient with colon cancer]. | a 75-year-old woman consulted her doctor in january 2014 because of pain in the dorsum of the hands, elbows, shoulders, and knees, bilaterally, and was diagnosed as having remitting seronegative symmetrical synovitis with pitting edema (rs3pe) syndrome. although the joint pain improved with low-dose prednisolone administration, she was referred to our department in april of 2014 because she had become aware of swelling of the right cervical lymph node. biopsy of the lymph node demonstrated that ... | 2015 | 26666720 |
| 5-hydroxymethylation of the ebv genome regulates the latent to lytic switch. | latent epstein-barr virus (ebv) infection and cellular hypermethylation are hallmarks of undifferentiated nasopharyngeal carcinoma (npc). however, ebv infection of normal oral epithelial cells is confined to differentiated cells and is lytic. here we demonstrate that the ebv genome can become 5-hydroxymethylated and that this dna modification affects ebv lytic reactivation. we show that global 5-hydroxymethylcytosine (5hmc)-modified dna accumulates during normal epithelial-cell differentiation, ... | 2015 | 26663912 |
| positive epstein-barr virus detection and mortality in respiratory failure patients admitted to the intensive care unit. | epstein-barr virus (ebv) infection may induce immune suppression in several ways, which may influence the proper host response to other pathogensand lead to a bad outcome of critically ill patients. | 2015 | 26663042 |
| the copy number of epstein-barr virus latent genome correlates with the oncogenicity by the activation level of lmp1 and nf-κb. | a tumor model that epstein-barr virus (ebv) latent infection facilitated the tumorigenicity was previously established using the maxi-ebv system. in the present approach, ebv-lost cell clones demonstrated significantly decreased tumorigenesis. on the other hand, the lmp1 gene in maxi-ebv genome was replaced by that of nasopharyngeal carcinoma origin. the resultant cell line, 293-1/nl showed much lower malignancy than the original 293-ebv. the result was opposite to our expectation. the change of ... | 2015 | 26517512 |
| epstein-barr virus-associated atraumatic spleen laceration presenting with neck and shoulder pain. | infectious mononucleosis, caused by the epstein-barr virus (ebv), is a common infection with worldwide distribution; more than 90% of people have been infected by adulthood. one of the most feared, albeit rare, complications, occurring in less than 0.5% of those infected, is splenic injury or rupture. | 2015 | 26516137 |
| the value of 18f-fdg pet in pediatric patients with post-transplant lymphoproliferative disorder at initial diagnosis. | ptld is a serious complication of both solid organ and bmt. this study assessed whether (18) f-fdg pet, when added to ct scan, had additional value in the initial evaluation of ptld in pediatric patients and whether pet/ct at baseline can reliably guide biopsy. this retrospective study evaluated 34 consecutive pediatric patients (14 female), aged 3.5-17.0 yr (mean age: 9.9 yr, s.d.: 4.9 yr), who had undergone (18) f-fdg pet/ct from may 2007 to december 2014 at initial diagnosis of ptld following ... | 2015 | 26515450 |
| declining incidence of nasopharyngeal carcinoma in brunei darussalam: a three decade study (1986-2014). | nasopharyngeal carcinoma (npc) is linked to epstein barr virus infection and is particularly common in the far east, particularly among some chinese groups. certain ethnicities have been reported to have low incidence of npc. this study looked at npc in brunei darussalam over a three decade period. | 2015 | 26514496 |
| association of ebv and hpv co-infection with the development of cervical cancer in ethnic uyghur women. | study on the role of epstein-barr virus (ebv) and human papillomavirus (hpv) infection in the development of cervical cancer. | 2015 | 26513880 |
| birc4 mutation: an important rare cause of uveitis. | we report a 6-year-old man with chronic severe recalcitrant bilateral anterior uveitis and a remote history of hemophagocytic lymphocytic histiocytosis secondary to epstein-barr virus infection. the patient was treated for idiopathic uveitis after an initial extensive evaluation failed to reveal a specific diagnosis. the patient failed to achieve sustained inactive disease with multiple monotherapies including topical glucocorticoid, methotrexate, infliximab, mycophenolate mofeti, and cyclospori ... | 2015 | 26513308 |
| combining plasma epstein-barr virus dna and nodal maximal standard uptake values of 18f-fluoro-2-deoxy-d-glucose positron emission tomography improved prognostic stratification to predict distant metastasis for locoregionally advanced nasopharyngeal carcinoma. | this study aimed to evaluate the value of combining the nodal maximal standard uptake values (suvmax) of (18) f-fluoro-2-deoxy-d-glucose positron emission tomography with epstein-barr virus dna(ebv dna) levels to predict distant metastasis for nasopharyngeal carcinoma (npc) patients. | 2015 | 26512922 |
| screening for nasopharyngeal cancer. | nasopharyngeal cancer is endemic in a few well-defined populations. the prognosis for advanced nasopharyngeal cancer is poor, but early-stage disease is curable and a high survival rate can be achieved. screening for early-stage disease could lead to improved outcomes. epstein-barr virus (ebv) serology and nasopharyngoscopy are most commonly used for screening. the efficacy and true benefit of screening remain uncertain due to potential selection, lead-time and length-time biases. | 2015 | 26544798 |
| detection of rearrangement of anaplastic lymphoma kinase (alk) and mutation of epidermal growth factor receptor (egfr) in primary pulmonary lymphoepithelioma-like carcinoma. | primary pulmonary lymphoepithelioma-like carcinoma (lelc) is a distinct rare subtype of lung cancer. the prevalence of anaplastic lymphoma kinase (alk) rearrangement and epidermal growth factor receptor (egfr) mutation in primary pulmonary lelc had not been thoroughly investigated. | 2015 | 26543602 |
| an efficient method for electroporation of small interfering rnas into encode project tier 1 gm12878 and k562 cell lines. | the encyclopedia of dna elements (encode) project aims to identify all functional sequence elements in the human genome sequence by use of high-throughput dna/cdna sequencing approaches. to aid the standardization, comparison, and integration of data sets produced from different technologies and platforms, the encode consortium selected several standard human cell lines to be used by the encode projects. the tier 1 encode cell lines include gm12878, k562, and h1 human embryonic stem cell lines. ... | 2015 | 26543439 |
| how should we treat early post-transplant lymphoproliferative disease after heart transplantation? | although post-transplant lymphoproliferative disease (ptld) is one of the major fatal complications encountered several years after heart transplant (htx), little is known about early-ptld emerging within the first year. we here describe the rare case of a 24-year-old female patient who suffered from early-ptld (dlbcl: diffuse large b-cell lymphoma) associated with an epstein-barr virus (ebv) infection, that developed around the jejunum at 7 months after htx. she suffered from acute abdominal pe ... | 2015 | 26549285 |
| lymphoepithelioma-like hepatocellular carcinoma without epstein-barr virus infection: a case report and a review of the literature. | lymphoepithelioma-like carcinoma (lelc) of the liver is uncommon, only 20 cases have been reported in the english-language literature so far, and the majority has been identified as cholangiocarcinomas, only four cases were hepatocellular lelc. here we described a rare case of lymphoepithelioma-like hepatocellular carcinoma (hcc). a 42-year-old chinese female who was incidentally found to have a liver-occupying lesion during a routine medical examination. ultrasonography revealed a 47 mm × 33 mm ... | 2015 | 26549091 |
| primary burkitt's lymphoma of the breast without epstein-barr virus infection: a case report and literature review. | burkitt lymphoma (bl) is a highly aggressive neoplasm, which arising from the germinal center or post germinal center b-cell. primary breast lymphomas are extremely rare, and the most common histologic type is diffuse large b-cell lymphoma. primary bl of the breast is much less common than the other types of lymphoma. here, we report an extremely rare case of a 37-year-old chinese female with localized bilateral breast, who was referred to our institution for bilateral breast swelling. the left ... | 2015 | 26549090 |
| extracavitary primary effusion lymphoma: a case report from india. | we present a case of extracavitary primary effusion lymphoma presenting, as jejunal polyps in a 38-year-old man. this is the first report of this entity from india. although rare in our country, the diagnosis should be suspected in cases of cd20 negative large cell lymphoma with plasmablastic or immunoblastic differentiation in seropositive patients. immunostaining for latency-associated nuclear antigen-1 and in situ hybridization for epstein-barr virus-associated rna will confirm the diagnosis. | 2015 | 26549075 |
| epstein-barr virus (ebv) tegument protein bglf2 promotes ebv reactivation through activation of the p38 mitogen-activated protein kinase. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus associated with both b cell and epithelial cell malignancies. ebv infection of b cells triggers activation of several signaling pathways that are critical for cell survival, virus latency, and growth transformation. to identify ebv proteins important for regulating cell signaling, we used a proteomic approach to screen viral proteins for ap-1 and nf-κb promoter activity in ap-1- and nf-κb-luciferase reporter assays. we found that ebv bglf ... | 2015 | 26559845 |
| identification and characterization of the physiological gene targets of the essential lytic replicative epstein-barr virus sm protein. | epstein-barr virus (ebv) sm protein is an essential lytic cycle protein with multiple posttranscriptional mechanisms of action. sm binds rna and increases accumulation of specific ebv transcripts. previous studies using microarrays and pcr have shown that sm-null mutants fail to accumulate several lytic cycle mrnas and proteins at wild-type levels. however, the complete effect of sm on the ebv transcriptome has been incompletely characterized. here we precisely identify the effects of sm on all ... | 2015 | 26559842 |
| epstein-barr virus gp350 can functionally replace the rhesus lymphocryptovirus major membrane glycoprotein and does not restrict infection of rhesus macaques. | primary epstein-barr virus (ebv) infection is the most common cause of infectious mononucleosis, and persistent infection is associated with multiple cancers. ebv vaccine development has focused on the major membrane glycoprotein, gp350, since it is the major target for antibodies that neutralize infection of b cells. however, ebv has tropism for both b cells and epithelial cells, and it is unknown whether serum neutralizing antibodies against b cell infection will provide sufficient protection ... | 2015 | 26559839 |
| higher frequency of cd4+cxcr5+icos+pd1+ t follicular helper cells in patients with infectious mononucleosis. | follicular helper t (tfh) cells are recognized as a distinct cd4helper t cell subset, and mainly dysregulated in the autoimmune disease, whether it plays a role in the infectious mononucleosis (im) diseases is unknown. in this study, we found that the cd4cxcr5 tfh cells were not significantly changed, but the cd4cxcr5icos and cd4cxcr5icospd1 tfh subsets were significantly increased in the im patients, and all these cells were significantly changed after antiviral therapy. second, only the number ... | 2015 | 26559315 |
| steroids for symptom control in infectious mononucleosis. | infectious mononucleosis, also known as glandular fever or the kissing disease, is a benign lymphoproliferative disorder. it is a viral infection caused by the epstein-barr virus (ebv), a ubiquitous herpes virus that is found in all human societies and cultures. epidemiological studies show that over 95% of adults worldwide have been infected with ebv. most cases of symptomatic infectious mononucleosis occur between the ages of 15 and 24 years. it is transmitted through close contact with an ebv ... | 2015 | 26558642 |
| array-based platform to select, release, and capture epstein-barr virus-infected cells based on intercellular adhesion. | microraft arrays were developed to select and separate cells based on a complex phenotype, weak intercellular adhesion, without knowledge of cell-surface markers or intracellular proteins. since the cells were also not competent to bind to a culture surface, a method to encapsulate nonadherent cells within a gelatin plug on the concave microraft surface was developed, enabling release and collection of the cells without the need for cell attachment to the microraft surface. after microraft colle ... | 2015 | 26558605 |
| a case of rheumatoid arthritis with methotrexate related lymphoproliferative diseases of the knee. | methotrexate (mtx) is the first choice disease-modifying antirheumatic drug (dmard) for rheumatoid arthritis (ra) and is referred to as an "anchor drug"; its use has been steadily increasing annually. however, mtx-related lymphoproliferative diseases (mtx-lpds) have emerged as important complications in the patients with ra. there have been no reports of intra-articular mtx-lpds of the patients with ra. atypical cells were found in the patient's joint fluid by cytological examinations, and mtx-l ... | 2015 | 26558294 |
| haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection. | patients with inflammatory bowel disease (ibd) are at risk of developing haemophagocytic lymphohistiocytosis (hlh) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. the two main causes of hlh in ibd patients are infection with cytomegalovirus and epstein-barr virus. patients with crohn's disease are more susceptible to hlh than those with ulcerative colitis. the majority of cases are seen in people receiving an immunosuppressive regimen that included ... | 2015 | 26557937 |
| possible contributing role of epstein-barr virus (ebv) as a cofactor in human papillomavirus (hpv)-associated cervical carcinogenesis. | persistent infection with ebv has been linked to the development of malignancies including hpv-associated cervical carcinoma. however, the role of ebv in hpv-associated cervical cancer is still poorly understood. | 2015 | 26551071 |
| multiple intestinal ulcers associated with primary epstein-barr virus infection in a patient with rheumatoid arthritis undergoing methotrexate therapy. | a 47-year-old woman with a 2-year history of rheumatoid arthritis (ra) undergoing methotrexate treatment developed a perforated ulcer in the ileum for which she underwent emergency surgery. a histological analysis of the extirpated specimen presented a possible epstein-barr virus (ebv) infection in the ulcerative lesion without a feature of lymphoproliferative disorder. interestingly, the patient's serological tests with a paired serum diagnosed a primary ebv infection. the present case emphasiz ... | 2015 | 26567997 |
| constitutive autophagy contributes to resistance to tp53-mediated apoptosis in epstein-barr virus-positive latency iii b-cell lymphoproliferations. | the epstein-barr virus (ebv) is associated with various lymphoproliferative disorders and lymphomas. we have previously demonstrated that treating wild-type tp53-expressing b cell lines with the tp53 pathway activator nutlin-3 induced apoptosis in ebv-negative and ebv-positive latency i cells whereas ebv-positive latency iii cells remained much more apoptosis-resistant. here, we report a constitutively high level of autophagy in these resistant cells which express high levels of the proautophagi ... | 2015 | 26565591 |
| neoadjuvant chemotherapy in locally advanced nasopharyngeal carcinoma: defining high-risk patients who may benefit before concurrent chemotherapy combined with intensity-modulated radiotherapy. | the purpose of this study was to create a prognostic model for distant metastasis in patients with locally advanced npc who accept concurrent chemotherapy combined with intensity-modulated radiotherapy (ccrt) to identify high-risk patients who may benefit from neoadjuvant chemotherapy (nact). a total of 881 patients with newly-diagnosed, non-disseminated, biopsy-proven locoregionally advanced npc were retrospectively reviewed; 411 (46.7%) accepted ccrt and 470 (53.3%) accepted nact followed by c ... | 2015 | 26564805 |
| novel treatment for early-stage nasal natural killer/t-cell lymphoma: intra-maxillary arterial infusion chemotherapy with concomitant radiotherapy. | nasal natural killer (nk)/t-cell lymphoma (nnktl) displays unusual clinicopathological features, and the prognosis is very poor, even in the early stages of the disease. for early stage nnktl, we have developed a novel chemoradiotherapy regimen incorporating arterial infusion chemotherapy, administered via the superficial temporal artery, in combination with radiotherapy. the novel arterial infusion regimen consists of ifosfamide, carboplatin, methotrexate, peplomycin, and etoposide (mpvic-p). f ... | 2015 | 26563973 |
| a young man presenting with pleuritic chest pain and fever after electrophysiological study and implantable cardioverter-defibrillator placement: diagnostic difficulties and value of bedside thoracic sonography. | we describe the case of a 23-year-old man presenting with recurrent pleuritic chest pain and prolonged fever after electrophysiology testing and placement of an implantable cardioverter-defibrillator because of a suspected arrhythmogenic right ventricular dysplasia. the clinical suspicion was initially directed toward pneumonia with pleural effusion and later toward an infection of the cardiac device complicated by septic pulmonary embolism. the definitive diagnosis of pulmonary embolism and inf ... | 2015 | 26576159 |
| epstein-barr virus mimicking lymphoma--a case report. | a 50-year-old male without a relevant medical history came to the emergency department with fever, muscle pain and fatigue without any localising symptoms. blood and urine cultures remained negative. laboratory work- up showed elevated liver enzymes and lactate dehydrogenase; epstein-barr virus (ebv) serology was negative. additional imaging showed a splenomegaly and cervical, axillary, mediastinal and hilar lymphadenopathy. pathological examination of one of the lymph nodes and bone marrow biop ... | 2015 | 26582808 |
| epstein-barr virus microrna mir-bart20-5p suppresses lytic induction by inhibiting bad-mediated caspase-3-dependent apoptosis. | epstein-barr virus (ebv) is a human gammaherpesvirus associated with a variety of tumor types. ebv can establish latency or undergo lytic replication in host cells. in general, ebv remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. when the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene expression and progeny virus production commence. thus far, the exact mechanism of ebv latency maintenance and the i ... | 2015 | 26581978 |
| ebv-mir-bart10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting btrc. | epstein-barr virus (ebv) infection is closely associated with tumorigenesis and development of nasopharyngeal carcinoma (npc), but the underlying molecular mechanisms remain poorly understood. it has been recently reported that ebv encodes 44 mature mirnas, some of which were found to promote tumor development by targeting virus-infected host genes or self-viral genes. however, few targets of ebv encoded-mirnas that are related to npc development have been identified to date. in this study, we r ... | 2015 | 26497204 |
| systemic epstein-barr virus-negative mature natural killer-cell lymphoma with cutaneous and visceral involvement. | 2015 | 26495897 | |
| posttransplant lymphoproliferative disorders following liver transplantation: where are we now? | liver transplantation has emerged as a life-saving treatment for several patients with acute liver failure, end stage liver disease and primary hepatic malignancies. however, long term immunosuppressive therapy aiming to reduce the risk of transplant rejection increases the incidence of several complications including malignancies. this is illustrated by the observation of a high ratio between observed and expected cases of lymphoproliferative disorders following liver transplantation. despite a ... | 2015 | 26494960 |
| an aggressive plasmablastic lymphoma of the oral cavity as primary manifestation of acquired immunodeficiency syndrome: case report and literature review. | introduction plasmablastic lymphoma is a rare entity that was first described in the jaws and the oral cavity of patients with human immunodeficiency virus (hiv) and acquired immunodeficiency syndrome (aids). plasmablastic lymphoma is considered as a diffuse, large, b-cell lymphoma with a unique phenotype and a predilection for the oral cavity. objective the authors describe a case of an aggressive plasmablastic lymphoma of the oral cavity as the primary manifestation of aids. resumed report we ... | 2015 | 26491484 |
| knockout of epstein-barr virus bplf1 retards b-cell transformation and lymphoma formation in humanized mice. | bplf1 of epstein-barr virus (ebv) is classified as a late lytic cycle protein but is also found in the viral tegument, suggesting its potential involvement at both initial and late stages of viral infection. bplf1 possesses both deubiquitinating and deneddylating activity located in its n-terminal domain and is involved in processes that affect viral infectivity, viral dna replication, dna repair, and immune evasion. a recently constructed ebv bplf1-knockout (ko) virus was used in conjunction wi ... | 2015 | 26489865 |
| [mechanisms of epstein-barr virus-mediated oncogenesis]. | epstein-barr virus(ebv), a ubiquitous human double-stranded dna virus, is associated with a variety of malignancies including burkitt's lymphoma, hodgkin's lymphoma, nasopharyngeal carcinoma, and gastric carcinoma. latent ebv infections have been discovered in cases of ebv -associated cancers, suggesting that ebv latent genes contribute to oncogenesis. here, i describe mechanisms of oncogenesis associated with ebv, focusing on functions of ebv latent membrane protein(lmp)and ebv-encoded small rn ... | 2015 | 26489540 |
| b-cell-rich t-cell lymphoma associated with epstein-barr virus-reactivation and t-cell suppression following antithymocyte globulin therapy in a patient with severe aplastic anemia. | b-cell lymphoproliferative disorder (b-lpd) is generally characterized by the proliferation of epstein-barr virus (ebv)-infected b lymphocytes. we here report the development of ebv-negative b-lpd associated with ebv-reactivation following antithymocyte globulin (atg) therapy in a patient with aplastic anemia. the molecular autopsy study showed the sparse ebv-infected clonal t cells could be critically involved in the pathogenesis of ebv-negative oligoclonal b-lpd through cytokine amplification ... | 2015 | 26487932 |
| a look into the evolution of epstein-barr virus-induced lymphoproliferative disorders: a case study. | epstein-barr virus (ebv)-induced lymphoproliferative disorders (lpds) are lymphoid proliferations arising as a result of the loss of an effective ebv-specific cytotoxic t-cell response. lpds may occur for primary or acquired impairment of the immune system, as well as in some persons without documented immunodeficiency. | 2015 | 26486748 |
| the potent tumor suppressor mir-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting anln and hspa4l. | nasopharyngeal carcinoma (npc) is a malignancy with poor prognosis that is endemic to southeast asia. we profiled micrornas (mirnas) of npcs using microarrays and confirmed the results by quantitative rt-pcr. the results revealed that seven mirnas were significantly up-regulated, and six mirnas were down-regulated, in npc tissues relative to noncancerous nasopharyngeal epithelia (nne). expression of mir-497 was also significantly reduced in the plasma of npc patients relative to the plasma of no ... | 2015 | 26486082 |
| identification of epstein-barr virus replication proteins in burkitt's lymphoma cells. | the working model to describe the mechanisms used to replicate the cancer-associated virus epstein-barr virus (ebv) is partly derived from comparisons with other members of the herpes virus family. many genes within the ebv genome are homologous across the herpes virus family. published transcriptome data for the ebv genome during its lytic replication cycle show extensive transcription, but the identification of the proteins is limited. we have taken a global proteomics approach to identify vir ... | 2015 | 26529022 |
| proteoglycan expression correlates with the phenotype of malignant and non-malignant ebv-positive b-cell lines. | the involvement of proteoglycans (pgs) in ebv-host interactions and lymphomagenesis remains poorly investigated. in this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, ng2, serglycin, decorin, biglycan, lumican, cd44), heparan sulphate (hs) metabolic system (ext1/2, ndst1/2, glce, hs2st1, hs3st1/2, hs6st1/2, sulf1/2, hpse) and extracellular matrix (ecm) components (collagen 1a1, fibronectin, elastin) in primary b cells and ebv carrying c ... | 2015 | 26527314 |
| [persistent infections in the children presenting with chronic ent diseases: the potential of etiotropic therapy]. | the objective of the present study that involved 176 children at the age varying from 2 to 12 years presenting with chronic ent diseases was etiological diagnostics and etiotropic therapy of these pathologies taking into consideration the duration of the disease of less than one year (n=72), from 1 to 2 years (n=54), and over 2 years (n=50). the bacteriological method was employed to identify microflora from the upper respiratory tract and the molecular-biological methods for the detection of ep ... | 2015 | 26525472 |
| [epstein-barr virus lmp1 oncogene variants in cell lines of different origin]. | it is well known that the epstein-barr virus (ebv) is a widespread infection in the human population. typically, infection occurs in early childhood without serious consequences for infected people. at the same time, a secondary infection with an additional ebv strain occurs quite often. during the in vitro cultivation of peripheral blood lymphocytes from persons infected with multiple strains of the virus, only one of these strains with higher transforming potential becomes dominant, while the ... | 2015 | 26510598 |
| spontaneous improvement in a pediatric patient with peripheral t-cell lymphoma. | peripheral t-cell lymphoma (ptcl) is rare in children, and it has a poor prognosis compared with other types of lymphoma. we report the case of a 7-year-old boy with spontaneous improvement of ptcl complicated by hemophagocytic syndrome as the initial symptom. he complained of pain and swelling of the right neck and presented with high fever. pancytopenia, liver dysfunction, elevated ferritin and soluble interleukin 2 receptor were noted on laboratory tests. peripheral blood plasma and white blo ... | 2015 | 26508191 |
| epstein-barr virus bzlf1-mediated downregulation of proinflammatory factors is essential for optimal lytic viral replication. | elevated secretion of inflammatory factors is associated with latent epstein-barr virus (ebv) infection and the pathology of ebv-associated diseases; however, knowledge of the inflammatory response and its biological significance during the lytic ebv cycle remains elusive. here, we demonstrate that the immediate early transcriptional activator bzlf1 suppresses the proinflammatory factor tumor necrosis factor alpha (tnf-α) by binding to the promoter of tnf-α and preventing nf-κb activation. a bzl ... | 2015 | 26537683 |
| induction of the lytic cycle sensitizes epstein-barr virus-infected b cells to nk cell killing that is counteracted by virus-mediated nk cell evasion mechanisms in the late lytic cycle. | epstein-barr virus (ebv) persists for the lifetime of the infected host despite eliciting strong immune responses. this persistence requires a fine balance between the host immune system and ebv immune evasion. accumulating evidence suggests an important role for natural killer (nk) cells in this balance. nk cells can kill ebv-infected cells undergoing lytic replication in vitro, and studies in both humans and mice with reconstituted human immune systems have shown that nk cells can limit ebv re ... | 2015 | 26537677 |
| [a girl with bilateral periorbital edema]. | an 11-year-old girl was seen with painless, bilateral periorbital edema, that had appeared a week before presentation. additional symptoms included fever, headache and malaise. serological tests performed three days later showed an active epstein-barr virus infection, which provided the diagnosis 'pfeiffer's disease'. bilateral periorbital edema can be the presenting manifestation of epstein-barr virus infection and should therefore be included in its differential diagnosis. | 2015 | 26469734 |
| identification of mef2b, ebf1, and il6r as direct gene targets of epstein-barr virus (ebv) nuclear antigen 1 critical for ebv-infected b-lymphocyte survival. | epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is the ebv-encoded nuclear antigen and sequence-specific dna binding protein required for viral origin binding and episome maintenance during latency. ebna1 can also bind to numerous sites in the cellular genome and can provide a host cell survival function, but it is not yet known how ebna1 sequence-specific binding is responsible for host cell survival. here, we integrate ebna1 chromatin immunoprecipitation sequencing (chip-seq) with transcrip ... | 2015 | 26468528 |
| the missing link in epstein-barr virus immune evasion: the bdlf3 gene induces ubiquitination and downregulation of major histocompatibility complex class i (mhc-i) and mhc-ii. | the ability of epstein-barr virus (ebv) to spread and persist in human populations relies on a balance between host immune responses and ebv immune evasion. cd8(+) cells specific for ebv late lytic cycle antigens show poor recognition of target cells compared to immediate early and early antigen-specific cd8(+) cells. this phenomenon is due in part to the early ebv protein bilf1, whose immunosuppressive activity increases with lytic cycle progression. however, published data suggest the existenc ... | 2015 | 26468525 |
| epstein-barr virus-associated inflammatory pseudotumor presenting as a colonic mass. | epstein-barr virus (ebv)-positive inflammatory pseudotumor (ipt) commonly involves spleen and liver and has only rarely been reported in the gastrointestinal (gi) tract. the spindle cells may express myofibroblastic or follicular dendritic cell markers. we report a challenging case of ebv-positive ipt arising in the ascending colon. the lesion was composed of spindle cells positive for smooth muscle actin but negative for all follicular dendritic cell markers tested and was associated with an ex ... | 2015 | 26477709 |
| animal models of tumorigenic herpesviruses--an update. | any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. by providing recent examples of animal models for epstein-barr virus and kaposi sarcoma-associated herpesvirus, we would argue that multiple animal models are needed to gain a comprehensive understanding of the pathogenesis associated with human oncogenic herpesviruses. transgenic mice, homologous animal herpesviruses, and tumorgraft and humanized mouse models all complement ea ... | 2015 | 26476352 |
| patient-derived tumor xenografts are susceptible to formation of human lymphocytic tumors. | patient-derived xenograft (pdx) tumor models have emerged as a new approach to evaluate the effects of cancer drugs on patients' personalized tumor grafts enabling to select the best treatment for the cancer patient and providing a new tool for oncology drug developers. here, we report that human tumors engrafted in immunodeficient mice are susceptible to formation of b-and t-cell pdx tumors. we xenografted human primary and metastatic tumor samples into immunodeficient mice and found that a fra ... | 2015 | 26476081 |
| epstein-barr virus encephalitis presenting as cerebellar hemorrhage. | epstein-barr virus (ebv) belongs to the human herpesvirus family and is ubiquitously found in the adult human population. the most common clinical manifestation of ebv is the syndrome of infectious mononucleosis. central nervous system involvement by ebv is rare, with very few cases of ebv encephalitis reported in the literature. the majority of these cases report cerebral cortical changes on magnetic resonance imaging. we present a rare case of ebv encephalitis in a young patient with meningiti ... | 2015 | 26475484 |
| induction of iκb-ζ by epstein-barr virus latent membrane protein-1 and cd30. | activation of nuclear factor-κb (nf-κb) in burkitt's lymphoma (bl) and hodgkin's lymphoma (hl) cells is important in the transformation and development process of these lymphomas. epstein-barr virus (ebv) latent membrane protein-1 (lmp-1) and ligand-independent signaling by overexpressed cd30 are known to cause permanent activation of nf-κb in lymphomas. however, hyperactivation of nf-κb triggers cellular senescence and apoptosis. here, we show that iκb-ζ, an inducible regulator of nf-κb, is con ... | 2015 | 26498461 |
| prognostic significance of epstein-barr virus infection in gastric cancer: a meta-analysis. | the prognostic significance of epstein-barr virus (ebv) infection in gastric cancer (gc) remains unclear. recently, a number of studies have investigated the association between ebv infection and the prognosis of gc with controversial results. we therefore conducted a meta-analysis to assess its prognostic significance. | 2015 | 26498209 |
| lymphoproliferative disorders after lung transplantation: clinicopathological characterization of 16 cases with identification of very-late-onset forms. | the incidence of posttransplant lymphoproliferative disorders (ptld) has recently declined, but late cases are increasingly reported in lung transplant recipients. | 2015 | 26506523 |
| stable intronic sequence rnas have possible regulatory roles in drosophila melanogaster. | stable intronic sequence rnas (sisrnas) have been found in xenopus tropicalis, human cell lines, and epstein-barr virus; however, the biological significance of sisrnas remains poorly understood. we identify sisrnas in drosophila melanogaster by deep sequencing, reverse transcription polymerase chain reaction, and northern blotting. we characterize a sisrna (sisr-1) from the regena (rga) locus and show that it can be processed from the precursor messenger rna (pre-mrna). we also document a cis-n ... | 2015 | 26504165 |
| a case of epstein-barr encephalitis with some curiosities. | we present the magnetic resonance imaging findings of an eight-year-old boy with epstein-barr virus (ebv) encephalitis, with special attention to lesion neuroanatomic distribution, diffusion-weighted images, and proton magnetic resonance spectroscopy (mrs). t2 and flair-weighted images showed bilateral and symmetric basal nuclei lesions, with diffusion facilitation. mrs of the lesions demonstrated elevated lactate/lipid and excitatory neurotransmitters. the purpose of this report is to alert to ... | 2015 | 26481185 |
| epstein-barr virus lmp1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and n-cadherin. | epstein-barr virus (ebv) is a γ-herpesvirus associated with human epithelial and b-cell malignancies. the ebv latent membrane protein (lmp) 1 is expressed in nasopharyngeal carcinoma (npc) and promotes oncogenic intracellular signaling mechanisms. lmp1 also promotes a pro-migratory phenotype through potential effects on cell surface proteins, as expression of lmp1 induces an epithelial-mesenchymal transition (emt) in epithelial cell lines. in this study, lmp1 was examined for potential effects o ... | 2015 | 26479443 |
| lymphoepithelioma-like hepatocellular carcinoma: case report and review of the literature. | lymphoepithelioma-like hepatocellular carcinoma (lel-hcc) is a rare form of undifferentiated carcinoma of the liver characterized by the presence of an abundant lymphoid infiltrate. here, a case of lel-hcc is described. an 81-year-old woman with a chronic hepatitis c infection was referred to the general surgery department of our hospital in august 2013 with a diagnosis of hcc. a past ultrasound examination had revealed a 60 mm-diameter nodular lesion in the third segment of the liver. after a n ... | 2015 | 26420974 |
| cd30-positive t-cell lymphoproliferative disease of the oral mucosa in children: a manifestation of epstein-barr virus-associated t-lymphoproliferative disorder. | eosinophilic ulcer of the oral mucosa (euom) is a very rare, benign, self-limiting ulcerative lesion of the oral cavity of unknown pathogenesis, and belongs to the same spectrum of cd30(+) t-cell lymphoproliferative disease (lpd) of the oral mucosa. the etiology and pathogenesis of the disease are unknown. we report two cases in children who were initially diagnosed with euom and cd30(+) t-cell lpd, respectively. however, retrospective analysis revealed that a majority of infiltrated atypical t ... | 2015 | 26420252 |
| systematic review and meta-analysis of the sero-epidemiological association between epstein-barr virus and rheumatoid arthritis. | infection with epstein-barr virus (ebv) has been suggested to contribute to the pathogenesis of autoimmune diseases, including rheumatoid arthritis (ra). we sought to determine whether prior infection with the virus occurs more frequently in patients with ra compared to controls. | 2015 | 26416719 |
| application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma. | nasopharyngeal carcinoma (npc) is an epstein barr virus (ebv)-related malignancy in which the tumor microenvironment plays a pivotal role in tumor progression. here, we developed two patient-derived xenograft (pdx) mouse lines from engrafted npc metastatic tumors. positive staining for ebv-encoded small rnas confirmed that these tumors harbored ebv, and gene expression profile analyses further showed that the pdx was highly similar to the primary parent tumor. in vivo drug screening using the pd ... | 2015 | 26416517 |
| primary immunodeficiencies and the control of epstein-barr virus infection. | human primary immunodeficiency (pid) states, where mutations in single immune system genes predispose individuals to certain infectious agents and not others, are experiments of nature that hold important lessons for the immunologist. the number of genetically defined pids is rising rapidly, as is the opportunity to learn from them. epstein-barr virus (ebv), a human herpesvirus, has long been of interest because of its complex interaction with the immune system. thus, it causes both infectious m ... | 2015 | 26415106 |
| extracavitary/solid variant of primary effusion lymphoma presenting as a gastric mass. | primary effusion lymphoma (pel) is a rare subtype of large b-cell lymphoma associated with human herpesvirus 8 (hhv8). it has the highest incidence in hiv-positive individuals. it often presents as a malignant pleural, peritoneal and/or pericardial effusion without a detectable solid mass. most cases are co-infected with epstein-barr virus (ebv). rare cases of hhv8-positive lymphoma with features similar to pel can present as tumor masses and are considered to represent an extracavitary or solid ... | 2015 | 26407759 |