Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| a novel virus-like particle based vaccine platform displaying the placental malaria antigen var2csa. | placental malaria caused by plasmodium falciparum is a major cause of mortality and severe morbidity. clinical testing of a soluble protein-based vaccine containing the parasite ligand, var2csa, has been initiated. var2csa binds to the human receptor chondroitin sulphate a (csa) and is responsible for sequestration of plasmodium falciparum infected erythrocytes in the placenta. it is imperative that a vaccine against malaria in pregnancy, if administered to women before they become pregnant, can ... | 2015 | 26599509 |
| biological characterization of the amazon coral micrurus spixii snake venom: isolation of a new neurotoxic phospholipase a2. | the micrurus genus is the american representative of elapidae family. micrurus spixii is endemic of south america and northern states of brazil. elapidic venoms contain neurotoxins that promote curare-mimetic neuromuscular blockage. in this study, biochemical and functional characterizations of m. spixii crude venom were performed and a new neurotoxic phospholipase a2 called mspla2-i was isolated. m. spixii crude venom caused severe swelling in the legs of tested mice and significant release of ... | 2015 | 26095535 |
| antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from new caledonian gardenia species (rubiaceae). | a series of 16 flavonoids were isolated and prepared from bud exudate of gardenia urvillei and gardenia oudiepe, endemic to new caledonia. most of them are rare polymethoxylated flavones. some of these compounds showed noticeable activity against leishmania (leishmania) amazonensis, plasmodium falciparum and trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. we also provide a full set of nmr data as some of the flavones were incomplete ... | 2015 | 25659770 |
| malaria and hiv infection in mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns. | malaria and human immunodeficiency virus (hiv) infection during pregnancy affect the transplacental transfer of antibodies against several pathogens from mother to fetus, although the effect of malaria and hiv infection on the transfer of antimalarial antibodies remains unclear. | 2015 | 25271267 |
| effect of deworming on disease progression markers in hiv-1-infected pregnant women on antiretroviral therapy: a longitudinal observational study from rwanda. | deworming human immunodeficiency virus (hiv)-infected individuals on antiretroviral therapy (art) may be beneficial, particularly during pregnancy. we determined the efficacy of targeted and nontargeted antihelminth therapy and its effects on plasmodium falciparum infection status, hemoglobin levels, cd4 counts, and viral load in pregnant, hiv-positive women receiving art. | 2015 | 25210019 |
| phytochemical composition, antiparasitic and α-glucosidase inhibition activities from pelliciera rhizophorae. | panama has an extensive mangrove area and it is one of the countries with the highest biodiversity in america. mangroves are widely used in traditional medicine, nevertheless, there are very few studies that validates their medicinal properties in america. given the urgent need for therapeutic options to treat several diseases of public health importance, mangrove ecosystem could be an interesting source of new bioactive molecules. this study was designed to evaluate the potential of pelliciera ... | 2015 | 26435737 |
| search for antiprotozoal activity in herbal medicinal preparations; new natural leads against neglected tropical diseases. | sleeping sickness, chagas disease, leishmaniasis, and malaria are infectious diseases caused by unicellular eukaryotic parasites ("protozoans"). the three first mentioned are classified as neglected tropical diseases (ntds) by the world health organization and together threaten more than one billion lives worldwide. due to the lack of research interest and the high increase of resistance against the existing treatments, the search for effective and safe new therapies is urgently required. in vie ... | 2015 | 26248069 |
| anti-protozoal activities of cembrane-type diterpenes from vietnamese soft corals. | based on our previous finding that certain cembranoid diterpenes possess selective toxicity against protozoan pathogens of tropical diseases such as trypanosoma and plasmodium, we have subjected a series of 34 cembranes isolated from soft corals living in the vietnamese sea to an in vitro screening for anti-protozoal activity against trypanosoma brucei rhodesiense (tbr), t. cruzi (tc), leishmania donovani (ld), and plasmodium falciparum (pf). twelve of the tested compounds displayed significant ... | 2015 | 26184133 |
| leishmania donovani infection drives the priming of human monocyte-derived dendritic cells during plasmodium falciparum co-infections. | functional impairment of dendritic cells (dcs) is part of a survival strategy evolved by leishmania and plasmodium parasites to evade host immune responses. here, the effects of co-exposing human monocyte-derived dcs to leishmania donovani promastigotes and plasmodium falciparum-infected erythrocytes were investigated. co-stimulation resulted in a dual, dose-dependent effect on dc differentiation which ranged from semi-mature cells, secreting low interleukin(-12p70 levels to a complete lack of p ... | 2015 | 26173941 |
| predicting antiprotozoal activity of benzyl phenyl ether diamine derivatives through qsar multi-target and molecular topology. | multi-target qsar is a novel approach that can predict simultaneously the activity of a given chemical compound on different pharmacological targets. in this work, we have used molecular topology and statistical tools such as multilinear regression analysis and artificial neural networks, to achieve a multi-target qsar model capable to predict the antiprotozoal activity of a group of benzyl phenyl ether diamine derivatives. the activity was related to three parasites with a high prevalence rate ... | 2015 | 25754076 |
| antiprotozoal activity and dna binding of dicationic acridones. | dicationic acridone derivatives were synthesized and their antiparasitic activity was evaluated. acridones displayed in vitro nanomolar ic50 values against trypanosoma brucei rhodesiense stib900 with selectivity indices >1000. compounds 1b, 3a, and 3b were as potent as the reference drug melarsoprol in this assay. submicromolar-range activities were observed against wild-type (nf54) and resistant (k1) strains of plasmodium falciparum, whereas no significant activity was detected against trypanos ... | 2015 | 25642604 |
| protozoan parasite growth inhibitors discovered by cross-screening yield potent scaffolds for lead discovery. | tropical protozoal infections are a significant cause of morbidity and mortality worldwide; four in particular (human african trypanosomiasis (hat), chagas disease, cutaneous leishmaniasis, and malaria) have an estimated combined burden of over 87 million disability-adjusted life years. new drugs are needed for each of these diseases. building on the previous identification of neu-617 (1) as a potent and nontoxic inhibitor of proliferation for the hat pathogen (trypanosoma brucei), we have now t ... | 2015 | 26087257 |
| profiling of small rna cargo of extracellular vesicles shed by trypanosoma cruzi reveals a specific extracellular signature. | over the last years, an expanding family of small regulatory rnas (e.g. micrornas, sirnas and pirnas) was recognized as key players in novel forms of post-transcriptional gene regulation in most eukaryotes. however, the machinery associated with ago/dicer-dependent small rna biogenesis was thought to be either entirely lost or extensively simplified in some unicellular organisms including trypanosoma cruzi, saccharomyces cerevisiae, leishmania major and plasmodium falciparum. although the biogen ... | 2015 | 25795082 |
| evaluation of aromatic 6-substituted thienopyrimidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria. | target repurposing is a proven method for finding new lead compounds that target trypanosoma brucei, the causative agent of human african trypanosomiasis. due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against t. brucei (ec50 = 42 nm) and selectivity over human host cells, we have explored other classes of human tyrosine kinase inhibitor scaffolds in order to expand the range of chemotypes for pursuit. following library expansion, we found compound 11e to have ... | 2015 | 25685309 |
| identification of selective inhibitors of the plasmodium falciparum hexose transporter pfht by screening focused libraries of anti-malarial compounds. | development of resistance against current antimalarial drugs necessitates the search for novel drugs that interact with different targets and have distinct mechanisms of action. malaria parasites depend upon high levels of glucose uptake followed by inefficient metabolic utilization via the glycolytic pathway, and the plasmodium falciparum hexose transporter pfht, which mediates uptake of glucose, has thus been recognized as a promising drug target. this transporter is highly divergent from mamm ... | 2015 | 25894322 |
| in vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of isolona hexaloba. | isolona hexaloba (pierre) engl. and diels (annonaceae) is traditionally used in d.r. congo against parasitic diseases including malaria. | 2015 | 26239153 |
| evaluation of antiplasmodial and antileishmanial activities of herbal medicine pseudelephantopus spiralis (less.) cronquist and isolated hirsutinolide-type sesquiterpenoids. | pseudelephantopus spiralis (less.) cronquist is distributed in the caribbean, mesoamerica and latin america. preparations of the plant are traditionally used in latin america for the treatment of various diseases including fever, malaria, and spleen or liver inflammations. | 2015 | 25980423 |
| fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits. | methods to discover biologically active small molecules include target-based and phenotypic screening approaches. one of the main difficulties in drug discovery is elucidating and exploiting the relationship between drug activity at the protein target and disease modification, a phenotypic endpoint. fragment-based drug discovery is a target-based approach that typically involves the screening of a relatively small number of fragment-like (molecular weight <300) molecules that efficiently cover c ... | 2015 | 25231971 |
| chemokines responses to plasmodium falciparum malaria and co-infections among rural cameroonians. | malaria remains the major cause of disease morbidity and mortality in sub-saharan africa with complex immune responses associated with disease outcomes. symptoms associated with severe malaria have generally shown chemokine upregulation but little is known of responses to uncomplicated malaria. eight villages in central cameroon of 1045 volunteers were screened. among these, malaria-positive individuals with some healthy controls were selected for chemokine analysis using enzyme-linked immunosor ... | 2015 | 25462711 |
| an efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents. | a new series of chalcones 5a-f were synthesized from caffeine-based aldehyde 3 and substituted acetophenones 4a-f. treatment of compounds 5a-f with hydrazine hydrate led to pyrazolines 6a-f, and their subsequent reaction with acetic anhydride or formic acid afforded the corresponding n-substituted pyrazolines 7a-f and 8a-f respectively. additionally, the regioselective cyclocondensation reaction of chalcones 5a-f with 4,5-diaminopyrazole 9 afforded the diazepine derivatives 10a-f. synthesis of t ... | 2015 | 25725376 |
| transcriptional changes induced by candidate malaria vaccines and correlation with protection against malaria in a human challenge model. | the complexity of immunity to malaria is well known, and clear correlates of protection against malaria have not been established. a better understanding of immune markers induced by candidate malaria vaccines would greatly enhance vaccine development, immunogenicity monitoring and estimation of vaccine efficacy in the field. we have previously reported complete or partial efficacy against experimental sporozoite challenge by several vaccine regimens in healthy malaria-naïve subjects in oxford. ... | 2015 | 26256523 |
| preclinical assessment of viral vectored and protein vaccines targeting the duffy-binding protein region ii of plasmodium vivax. | malaria vaccine development has largely focused on plasmodium falciparum; however, a reawakening to the importance of plasmodium vivax has spurred efforts to develop vaccines against this difficult to treat and at times severe form of relapsing malaria, which constitutes a significant proportion of human malaria cases worldwide. the almost complete dependence of p. vivax red blood cell invasion on the interaction of the p. vivax duffy-binding protein region ii (pvdbp_rii) with the human duffy an ... | 2015 | 26217340 |
| gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action. | malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. we have conducted a screen for antiplasmodial compounds by using a natural product library. here we report on cyclomarin a as a potent growth inhibitor of plasmodium falciparum and the identification of its molecular target, diadenosine triphosphate hydrolase (pfap3aase), by chemical proteomics. using a biochemical assa ... | 2015 | 26472355 |
| synthesis, antimalarial and antitubercular activities of meridianin derivatives. | meridianins are marine-derived indole alkaloids, known to possess kinase inhibitory and antimalarial activities. a series of n-aryl and heteroaryl sulfonamide derivatives of meridianins were prepared and screened for antimalarial activity against d6 and w2 strains of plasmodium falciparum. 2-nitro-4-trifluoromethyl sulfonamide derivative 14v displayed promising antiplasmodial activity against both strains with ic50 values of 2.56 and 3.41 μm, respectively. these compounds were not cytotoxic to m ... | 2015 | 26005918 |
| virtually designed triclosan-based inhibitors of enoyl-acyl carrier protein reductase of mycobacterium tuberculosis and of plasmodium falciparum. | we report here new chemical structures of predicted nanomolar triclosan-based inhibitors (tcls) of mycobacterium tuberculosis enoyl-acyl carrier protein reductase (inha) virtually proposed by computer-assisted molecular design. 3d models of inha-tcl complexes were prepared by in situ modifications of the reference crystal structure (pdb entry 1p45) for a training set of 15 tcls with known inha inhibitory activities. a qsar model was built leading to linear correlation between the calculated free ... | 2015 | 27490275 |
| host icams play a role in cell invasion by mycobacterium tuberculosis and plasmodium falciparum. | intercellular adhesion molecules (icams) belong to the immunoglobulin superfamily and participate in diverse cellular processes including host-pathogen interactions. icam-1 is expressed on various cell types including macrophages, whereas icam-4 is restricted to red blood cells. here we report the identification of an 11-kda synthetic protein, m5, that binds to human icam-1 and icam-4, as shown by in vitro interaction studies, surface plasmon resonance and immunolocalization. m5 greatly inhibits ... | 2015 | 25586702 |
| plasmodium berghei anka causes intestinal malaria associated with dysbiosis. | gastrointestinal symptoms, such as abdominal pain and diarrhea, are frequently observed in patients with plasmodium falciparum malaria. however, the correlation between malaria intestinal pathology and intestinal microbiota has not been investigated. in the present study, infection of c57bl/6 mice with p. berghei anka (pba) caused intestinal pathological changes, such as detachment of epithelia in the small intestines and increased intestinal permeability, which correlated with development with ... | 2015 | 26503461 |
| a novel pyrazolopyridine with in vivo activity in plasmodium berghei- and plasmodium falciparum-infected mouse models from structure-activity relationship studies around the core of recently identified antimalarial imidazopyridazines. | toward improving pharmacokinetics, in vivo efficacy, and selectivity over herg, structure-activity relationship studies around the central core of antimalarial imidazopyridazines were conducted. this study led to the identification of potent pyrazolopyridines, which showed good in vivo efficacy and pharmacokinetics profiles. the lead compounds also proved to be very potent in the parasite liver and gametocyte stages, which makes them of high interest. | 2015 | 26502160 |
| vascular endothelial growth factor (vegf) and lovastatin suppress the inflammatory response to plasmodium berghei infection and protect against experimental cerebral malaria. | cerebral malaria (cm) is a severe complication of plasmodium falciparum infection, which is associated with high mortality and long-term cognitive impairment even when effective anti-parasitic treatment is administered. (1 , 2) supportive therapy is needed to improve both morbidity and mortality associated with this condition. in an accompanying paper, we have demonstrated that in the plasmodium berghei anka (pba) rodent model, cm can be effectively prevented by a treatment combining sub-lethal ... | 2015 | 26392164 |
| vegf and lps synergistically silence inflammatory response to plasmodium berghei infection and protect against cerebral malaria. | malaria infection induces, alongside endothelial damage and obstruction hypoxia, a potent inflammatory response similar to that observed in other systemic diseases caused by bacteria and viruses. accordingly, it is increasingly recognised that cerebral malaria (cm), the most severe and life threatening complication of plasmodium falciparum infection, bears a number of similarities with sepsis, an often fatal condition associated with a misregulated inflammatory response triggered by systemic mic ... | 2015 | 26392042 |
| brine shrimp cytotoxicity and antimalarial activity of plants traditionally used in treatment of malaria in msambweni district. | in kenya, most people use traditional medicine and medicinal plants to treat many diseases including malaria. to manage malaria, new knowledge and products are needed. traditional herbal medicine has constituted a good basis for antimalarial lead discovery and drug development. | 2015 | 25495507 |
| bioactivity-guided isolation of antiplasmodial constituents from conyza sumatrensis (retz.) e.h. walker. | conyza sumatrensis (retz.) e.h. walker (cs) leaves are used for traditional treatment of malaria in cameroon. however, the antimalarial activity of the leaf constituents of this plant is still unexplored. the aim of our investigation was to evaluate the antiplasmodial activity of some bioactive constituents from cs leaves. compounds were isolated from cs leaves and structurally elucidated using extensive spectroscopic analysis. the in vitro antiplasmodial activity of the extracts and pure compou ... | 2015 | 25449289 |
| direct evidence for the atovaquone action on the plasmodium cytochrome bc1 complex. | atovaquone, a coenzyme q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. various mutations in the quinone binding site of the cytochrome b gene of plasmodium spp. such as m133i, l144s, l271v, k272r, y268c, y268s, y268n, and v284f are suggesting to associate with resistance to atovaquone. there is no direct evidence of relation between the mutations and resistance to atovaquone in pl ... | 2015 | 25264100 |
| naghibione; a novel sesquiterpenoid with antiplasmodial effect from dorema hyrcanum koso-pol. root, a plant used in traditional medicine. | some dorema species are used in persian traditional medicine. in the present study the total extract from the roots of dorema hyrcanum koso-pol. was investigated for its in-vitro (pldh assay) and in-vivo (peters' 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line mdbk (mtt test). the ic50 values for a chloroquine- sensitive (3d7) and a chloroquine- resistant (k1) strain of plasmodium falciparum were 28.64 and 9.79 µg/ml, respectively. the i ... | 2015 | 26330887 |
| in vivo evaluation of isolated triterpenes and semi-synthetic derivatives as antimalarial agents. | the triterpenes balsaminoside b (1) and karavilagenin c (2) were isolated from the african medicinal plant momordica balsamina l. karavoates b (3) and d (4) were synthesized by diacylation of 2 with acetic and propionic anhydrides, respectively. in previous work, derivatives 3 and 4 exhibited submicromolar median inhibitory concentrations (ic50) in vitro against plasmodium falciparum welch (human malaria parasite) strains 20 to 25 times lower than those of natural product 2. the main objective o ... | 2015 | 26301556 |
| the hfe genotype and a formulated diet controlling for iron status attenuate experimental cerebral malaria in mice. | plasmodium falciparum infects approximately 500million individuals each year. a small but significant number of infections lead to complications such as cerebral malaria. cerebral malaria is associated with myelin damage and neurological deficits in survivors, and iron status is thought to impact the outcome of infection. we evaluated whether a mouse model of experimental cerebral malaria with plasmodium berghei anka strain was altered by dietary iron deficiency or genetic iron overload (h67d hf ... | 2015 | 26296689 |
| antimalarial benzoheterocyclic 4-aminoquinolines: structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies. | a novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against k1 (multidrug resistant) and nf54 (sensitive) strains of the malaria parasite plasmodium falciparum. structure-activity relationship studies led to the identification of highly promising analogues, the most potent of which had ic50s in the nanomolar range against both strains. the compounds further demonstrated good in ... | 2015 | 26264839 |
| anti-plasmodium falciparum activity of quinoline-sulfonamide hybrids. | fifteen quinoline-sulfonamide hybrids, with a 7-chloroquinoline moiety connected by a linker group to arylsulfonamide moieties with different substituents in the 4-position were synthesized and assayed against plasmodium falciparum. the compounds displayed high schizonticidal blood activity in vitro, with ic50 values ranging from 0.05 to 1.63 μm, in the anti-hpr2 assay against clone w2-chloroquine-resistant; ten of them showed an ic50 (ranging from 0.05 to 0.40 μm) lower than that of chloroquine ... | 2015 | 26190461 |
| kix domain specific immunoglobulin a can protect from adverse lung and cerebral pathology induced by plasmodium berghei anka. | plasmodium specific iga has been detected in serum and breast milk among the endemic population but the role it can play in vivo is not clear. in this report, we demonstrate the utility of malaria specific iga, elicited by peptide sequences (referred as mpep3 and mpep4) of region vi of eba-175 (pfrvi). immunization of mice with klh tagged or untagged peptides of mpep3, mpep4 or with pfrvi have resulted in specific iga response that inhibits the in vitro invasion of plasmodium falciparum merozoit ... | 2015 | 26188504 |
| protective activity of biflavanones from garcinia kola against plasmodium infection. | garcinia kola is a medicinal plant traditionally used for malaria therapy in central africa. | 2015 | 26129936 |
| metabolic signature profiling as a diagnostic and prognostic tool in pediatric plasmodium falciparum malaria. | background. accuracy in malaria diagnosis and staging is vital to reduce mortality and post infectious sequelae. in this study, we present a metabolomics approach to diagnostic staging of malaria infection, specifically plasmodium falciparum infection in children. methods. a group of 421 patients between 6 months and 6 years of age with mild and severe states of malaria with age-matched controls were included in the study, 107, 192, and 122, individuals, respectively. a multivariate design was ... | 2015 | 26110164 |
| p-selectin is a host receptor for plasmodium msp7 ligands. | plasmodium parasites typically elicit a non-sterile but protective immune response in human host populations, suggesting that the parasites actively modulate normal immunological mechanisms. p-selectin is a cell surface receptor expressed in mammals, that is a known component of the inflammatory response against pathogens and has been previously identified as a host factor that influences malaria-associated pathology both in human patients and rodent infection models. | 2015 | 26045295 |
| n-cinnamoylation of antimalarial classics: effects of using acyl groups other than cinnamoyl toward dual-stage antimalarials. | in a follow-up study to our reports of n-cinnamoylated chloroquine and quinacrine analogues as promising dual-stage antimalarial leads with high in vitro potency against both blood-stage plasmodium falciparum and liver-stage plasmodium berghei, we decided to investigate the effect of replacing the cinnamoyl moiety with other acyl groups. thus, a series of n-acylated analogues were synthesized, and their activities against blood- and liver-stage plasmodium spp. were assessed along with their in v ... | 2015 | 26038181 |
| aspidosperma (apocynaceae) plant cytotoxicity and activity towards malaria parasites. part ii: experimental studies withaspidosperma ramiflorum in vivo and in vitro. | several species of aspidosperma plants are used to treat diseases in the tropics, including aspidosperma ramiflorum, which acts against leishmaniasis, an activity that is experimentally confirmed. the species, known as guatambu-yellow, yellow peroba, coffee-peroba and matiambu, grows in the atlantic forest of brazil in the south to the southeast regions. through a guided biofractionation of a. ramiflorum extracts, the plant activity against plasmodium falciparum was evaluated in vitro for toxici ... | 2015 | 26560981 |
| enantiopure indolizinoindolones with in vitro activity against blood- and liver-stage malaria parasites. | malaria continues to be a major cause of morbidity and mortality to this day, and resistance to drugs like chloroquine has led to an urgent need to discover novel chemical entities aimed at new targets. here, we report the discovery of a novel class of potential antimalarial compounds containing an indolizinoindolone scaffold. these novel enantiopure indolizinoindolones were synthesized, in good-to-excellent yields and excellent diastereoselectivities, by cyclocondensation reaction of (s)- or (r ... | 2015 | 26525306 |
| the cytoplasmic prolyl-trna synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. | the emergence of drug resistance is a major limitation of current antimalarials. the discovery of new druggable targets and pathways including those that are critical for multiple life cycle stages of the malaria parasite is a major goal for developing next-generation antimalarial drugs. using an integrated chemogenomics approach that combined drug resistance selection, whole-genome sequencing, and an orthogonal yeast model, we demonstrate that the cytoplasmic prolyl-trna (transfer rna) syntheta ... | 2015 | 25995223 |
| advances in molecular genetic systems in malaria. | robust tools for analysing gene function in plasmodium parasites, which are the causative agents of malaria, are being developed at an accelerating rate. two decades after genetic technologies for use in plasmodium spp. were first described, a range of genetic tools are now available. these include conditional systems that can regulate gene expression at the genome, transcriptional or protein level, as well as more sophisticated tools for gene editing that use piggybac transposases, integrases, ... | 2015 | 25978707 |
| trafficking of the signature protein of intra-erythrocytic plasmodium berghei-induced structures, ibis1, to p. falciparum maurer's clefts. | remodeling of the host red blood cell by plasmodium falciparum is well established and crucial for infection and parasite virulence. host cell modifications are not exclusive to human plasmodium parasites and also occur in hepatocytes and erythrocytes infected with murine plasmodium parasites. the recently described intra-erythrocytic p. berghei-induced structures (ibis) share similarities to p. falciparum maurer's clefts. it is shown here that a potential candidate ibis1 homologue in p. falcipa ... | 2015 | 25956941 |
| in vivo antimalarial activity of α-mangostin and the new xanthone δ-mangostin. | based on the previously reported in vitro antiplasmodial activity of several xanthones from garcinia mangostana, two xanthones, α-mangostin and a new compound, δ-mangostin, were isolated from mangosteen husk, and the in vitro antiplasmodial and cytotoxic effects were determined. α-mangostin was more active against the resistant plasmodium falciparum chloroquine-resistant (fcr3) strain (ic50 = 0.2 ± 0.01 μm) than δ-mangostin (ic50 = 121.2 ± 1.0 μm). furthermore, the therapeutic response accordi ... | 2015 | 25943035 |
| new quinoline derivatives demonstrate a promising antimalarial activity against plasmodium falciparum in vitro and plasmodium berghei in vivo. | malaria continues to be an important public health problem in the world. nowadays, the widespread parasite resistance to many drugs used in antimalarial therapy has made the effective treatment of cases and control of the disease a constant challenge. therefore, the discovery of new molecules with good antimalarial activity and tolerance to human use can be really important in the further treatment of the disease. in this study we have investigated the antiplasmodial activity of 10 synthetic com ... | 2015 | 25920564 |
| targeting the cell stress response of plasmodium falciparum to overcome artemisinin resistance. | successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. thus, reports that resistance to artemisinins (arts) has emerged, and that the prevalence of this resistance is increasing, are alarming. art resistance has recently been linked to mutations in the k13 propeller protein. we undertook a detailed kinetic analysis of the drug responses of k13 wild-type and mutant isolates of plasmodium falciparum sourced from a region in cambodia (pailin). ... | 2015 | 25901609 |
| anti-malarial activity and toxicity assessment of himatanthus articulatus, a plant used to treat malaria in the brazilian amazon. | plasmodium falciparum has become resistant to some of the available drugs. several plant species are used for the treatment of malaria, such as himatanthus articulatus in parts of brazil. the present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of h. articulatus. | 2015 | 25888719 |
| the t-cell inhibitory molecule butyrophilin-like 2 is up-regulated in mild plasmodium falciparum infection and is protective during experimental cerebral malaria. | plasmodium falciparum infection can result in severe disease that is associated with elevated inflammation and vital organ dysfunction; however, malaria-endemic residents gain protection from lethal outcomes and manifest only mild symptoms during infection. to characterize host responses associated with this more effective antimalarial response, we characterized whole-blood transcriptional profiles in rwandan adults during a mild malaria episode and compared them with findings from a convalescen ... | 2015 | 25883389 |
| in vivo function of ptex88 in malaria parasite sequestration and virulence. | malaria pathology is linked to remodeling of red blood cells by eukaryotic plasmodium parasites. central to host cell refurbishment is the trafficking of parasite-encoded virulence factors through the plasmodium translocon of exported proteins (ptex). much of our understanding of its function is based on experimental work with cultured plasmodium falciparum, yet direct consequences of ptex impairment during an infection remain poorly defined. using the murine malaria model parasite plasmodium be ... | 2015 | 25820521 |
| in vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol derivatives. | 4-nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from piper peltatum roots. o-acylation or o-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. the aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in plasmodium falciparum cultures, and in vivo antimalarial activity of several 4-nerolidylcatechol derivatives. 1,2-o,o-diacetyl ... | 2015 | 25801563 |
| oral lipid-based nanoformulation of tafenoquine enhanced bioavailability and blood stage antimalarial efficacy and led to a reduction in human red blood cell loss in mice. | tafenoquine (tq), a new synthetic analog of primaquine, has relatively poor bioavailability and associated toxicity in glucose-6-phosphate dehydrogenase (g6pd)-deficient individuals. a microemulsion formulation of tq (mtq) with sizes <20 nm improved the solubility of tq and enhanced the oral bioavailability from 55% to 99% in healthy mice (area under the curve 0 to infinity: 11,368±1,232 and 23,842±872 min·μmol/l) for reference tq and mtq, respectively. average parasitemia in plasmodium berghei- ... | 2015 | 25759576 |
| synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. | several bicyclic compounds, 3-azabicyclo[3.2.2]nonanes, have been prepared. the new compounds were tested for their activities against one strain of the causative organism of malaria tropica, plasmodium falciparum k1, which is resistant against chloroquine and pyrimethamine. in addition, their cytotoxicity and their activity against the pathogen of the east african form of sleeping sickness, trypanosoma brucei rhodesiense, were investigated. structure-activity relationships are discussed conside ... | 2015 | 25746816 |
| critical role of il-33 receptor st2 in experimental cerebral malaria development. | cerebral malaria, a severe complication of plasmodium falciparum infection, can be modeled in murine plasmodium berghei anka (pba) infection. pba-induced experimental cerebral malaria (ecm) is cd8(+) t-cell mediated, and influenced by th 1/th 2 balance. here, we show that il-33 expression is increased in brain undergoing ecm and we address the role of the il-33/st2 pathway in ecm development. st2-deficient mice were resistant to pba-induced neuropathology. they survived >20 days with no ecm neur ... | 2015 | 25682948 |
| host erythrocyte environment influences the localization of exported protein 2, an essential component of the plasmodium translocon. | malaria parasites replicating inside red blood cells (rbcs) export a large subset of proteins into the erythrocyte cytoplasm to facilitate parasite growth and survival. ptex, the parasite-encoded translocon, mediates protein transport across the parasitophorous vacuolar membrane (pvm) in plasmodium falciparum-infected erythrocytes. proteins exported into the erythrocyte cytoplasm have been localized to membranous structures, such as maurer's clefts, small vesicles, and a tubovesicular network. c ... | 2015 | 25662767 |
| antimalarial activity of 4-amidinoquinoline and 10-amidinobenzonaphthyridine derivatives. | chloroquine (cq) has been used as first line malaria therapeutic drug for decades. emergence of cq drug-resistant plasmodium falciparum malaria throughout endemic areas of the world has limited its clinical value. mefloquine (mq) has been used as an effective malaria prophylactic drug due to its being long-acting and having a high potency against blood stage p. falciparum (pf). however, serious cns toxicity of mq has compromised its clinical value as a prophylaxis drug. therefore, new and inexpe ... | 2015 | 25654185 |
| in vitro synergistic effect of fluoroquinolone analogues in combination with artemisinin against plasmodium falciparum; their antiplasmodial action in rodent malaria model. | emergence of drug-resistant parasite strains has surfaced as a major obstacle in attempts to ameliorate malaria. current treatment regimen of malaria relies on the concept of artemisinin-based combination therapy (act). | 2015 | 25652883 |
| prodrugs of reverse fosmidomycin analogues. | fosmidomycin inhibits ispc (dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in plasmodium falciparum. the drug has been used successfully to treat malaria patients in clinical studies, thus validating ispc as an antimalarial target. however, improvement of the drug's pharmacodynamics and pharmacokinetics is desirable. here, we show that the conversion of the phosphonate moiety into acyloxymethyl and alkoxycarbonyloxym ... | 2015 | 25633870 |
| cannabidiol increases survival and promotes rescue of cognitive function in a murine model of cerebral malaria. | cerebral malaria (cm) is a severe complication resulting from plasmodium falciparum infection that might cause permanent neurological deficits. cannabidiol (cbd) is a nonpsychotomimetic compound of cannabis sativa with neuroprotective properties. in the present work, we evaluated the effects of cbd in a murine model of cm. female mice were infected with plasmodium berghei anka (pba) and treated with cbd (30mg/kg/day - 3 or 7days i.p.) or vehicle. on 5th day-post-infection (dpi), at the peak of t ... | 2015 | 25595981 |
| lipoxin a4 attenuates endothelial dysfunction during experimental cerebral malaria. | a breakdown of the brain-blood barrier (bbb) due to endothelial dysfunction is a primary feature of cerebral malaria (cm). lipoxins (lx) are specialized pro-resolving mediators that attenuate endothelial dysfunction in different vascular beds. it has already been shown that lxa4 prolonged plasmodium berghei-infected mice survival by a mechanism that depends on inhibiting il-12 production and cd8(+)ifn-γ(+) t cells in brain tissue; however, the effects of this treatment on endothelial dysfunction ... | 2015 | 25576659 |
| efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (np046) in a mouse model. | even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. according to the world malaria report 2013, in 2012 there were an estimated 207 million malaria cases and 627,000 deaths. thus, the discovery and development of new, effective anti-malarial drugs are required. to achieve this goal, the department of chemistry at the university of the free sta ... | 2015 | 25563929 |
| experimental study of the relationship between plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions. | the evaluation of transmission reducing interventions (tri) to control malaria widely uses membrane feeding assays. in such assays, the intensity of plasmodium infection in the vector might affect the measured efficacy of the candidates to block transmission. gametocyte density in the host blood is a determinant of the infection success in the mosquito, however, uncertain estimates of parasite densities and intrinsic characteristics of the infected blood can induce variability. to reduce this va ... | 2015 | 25541384 |
| comparative analysis of apicoplast-targeted protein extension lengths in apicomplexan parasites. | in general, the mechanism of protein translocation through the apicoplast membrane requires a specific extension of a functionally important region of the apicoplast-targeted proteins. the corresponding signal peptides were detected in many apicomplexans but not in the majority of apicoplast-targeted proteins in toxoplasma gondii. in t. gondii signal peptides are either much diverged or their extension region is processed, which in either case makes the situation different from other studied api ... | 2015 | 26114107 |
| new heterocyclic hybrids of pyrazole and its bioisosteres: design, synthesis and biological evaluation as dual acting antimalarial-antileishmanial agents. | a new series of pyrazole derivatives were synthesized by hybridization with five-membered heterocyclic moieties such as thiazoles, thiazolidinones, 1,3,4-thiadiazoles and pyrazolines. the compounds were evaluated for their in vivo antimalarial activity against plasmodium berghei infected mice and the most active derivatives were further examined for their in vitro antimalarial activity against chloroquine resistant (rkl9) strain of plasmodium falciparum. compounds 2c, 2d, 4b, 4c, 4d, 5a, 6c, 8c ... | 2015 | 25768697 |
| evaluation of the antiplasmodial properties of selected plants in southern ethiopia. | the majority of the ethiopian population is at risk of malaria largely caused by plasmodium falciparum. the resistance of the parasite to existing drugs is the main challenge in the control of the disease and thus new therapeutic drugs are required. in ethiopia, people use different plant species to treat malaria. however, very few of them have so far been evaluated for their safety level and antimalarial activity. thus, the aim of this study was to evaluate the safety and antimalarial activity ... | 2015 | 26698300 |
| in vitro and in vivo anti-malarial activity of plants from the brazilian amazon. | the anti-malarials quinine and artemisinin were isolated from traditionally used plants (cinchona spp. and artemisia annua, respectively). the synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. malaria is endemic to the amazon region where plasmodium falciparum and plasmodium vivax drug-resistance is of concern. there is an urgent need for new anti-malarials. traditionally used amazoni ... | 2015 | 26682750 |
| antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model. | during the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. chloroquine acts by forming toxic complexes with haem molecules and interfering with their crystallization. in chloroquine-resistant strains, the drug is excluded from the site of action, which causes the parasites to accumulate less chloroquine in their acid food vacuoles than chloroquine-sensitive parasites. 3-hydroxylpyridin-4-ones are known to ... | 2015 | 26671222 |
| tailoring a combination preerythrocytic malaria vaccine. | the leading malaria vaccine candidate, rts,s, based on the plasmodium falciparum circumsporozoite protein (csp), will likely be the first publicly adopted malaria vaccine. however, this and other subunit vaccines, such as virus-vectored thrombospondin-related adhesive protein (trap), provide only intermediate to low levels of protection. in this study, the plasmodium berghei homologues of antigens csp and trap are combined. trap is delivered using adenovirus- and vaccinia virus-based vectors in ... | 2015 | 26667840 |
| stearylamine liposomal delivery of monensin in combination with free artemisinin eliminates blood stages of plasmodium falciparum in culture and p. berghei infection in murine malaria. | the global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. therefore, there is a critical need to develop an efficient drug delivery system to circumvent drug resistance. the anticoccidial drug monensin, a carboxylic ionophore, has been shown to have antimalarial properties. here, we developed a liposome-based drug delivery of monensin and evaluated its antimalarial activity in lipid formulations of soya phosphatidylcholine (spc) chole ... | 2015 | 26666937 |
| evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent. | this study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally related to the naturally-occurring lapachol and lapachone. of the compounds tested, 3-(3-methylbut-1-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl acetate (1) was the most active against plasmodium falciparum among both natural and semi-synthetic naphthoquinones, showing potent and selective activity. compound 1 was able to reduce the in vitro parasite burden, in vitro ... | 2015 | 25431148 |
| histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans. | current antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. we previously reported promising in vitro parasite-killing activity with the histone methyltransferase inhibitor bix-01294 and its analogue tm2-115. here, we further characterize these diaminoquinazolines for in vitro and in vivo efficacy and pharmacokinetic properties to prioritize and direct compound development. bix-01294 and tm2-115 displayed potent in vitro activity, ... | 2015 | 25421480 |
| in vitro alterations do not reflect a requirement for host cell cycle progression during plasmodium liver stage infection. | prior to invading nonreplicative erythrocytes, plasmodium parasites undergo their first obligate step in the mammalian host inside hepatocytes, where each sporozoite replicates to generate thousands of merozoites. while normally quiescent, hepatocytes retain proliferative capacity and can readily reenter the cell cycle in response to diverse stimuli. many intracellular pathogens, including protozoan parasites, manipulate the cell cycle progression of their host cells for their own benefit, but i ... | 2015 | 25416236 |
| red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. | many red cell polymorphisms are a result of selective pressure by the malarial parasite. here, we add another red cell disease to the panoply of erythrocytic changes that give rise to resistance to malaria. erythrocytes from individuals with erythropoietic protoporphyria (epp) have low levels of the final enzyme in the heme biosynthetic pathway, ferrochelatase. cells from these patients are resistant to the growth of plasmodium falciparum malarial parasites. this phenomenon is due to the absence ... | 2015 | 25414439 |
| molecular cloning, characterization and expression profile of a glutathione peroxidase-like thioredoxin peroxidase (tpxgl) of the rodent malaria parasite plasmodium berghei. | glutathione peroxidases (gpx) comprise an important group of redox active proteins with diverse functions, including antioxidant defense and signaling. although the genome of the malaria parasite plasmodium does not contain a genuine gpx gene a glutathione peroxidase-like thioredoxin peroxidase (tpx(gl)) has recently been identified and biochemically characterized in the human malaria parasite p. falciparum. to gain more insight into the potential biological function of this enzyme we have clone ... | 2015 | 24637102 |
| formulation development and evaluation of the anti-malaria properties of sustained release artesunate-loaded solid lipid microparticles based on phytolipids. | contexts: artemisinins and its derivatives are considered the basis in the treatment of plasmodium falciparum malaria due to their high potency and rapid action. however, they have short half life, low solubility, and poor oral bioavailability, hence the need to formulate sustained release lipid particulate dosage form of these drugs. | 2015 | 24479677 |
| jpc-2997, a new aminomethylphenol with high in vitro and in vivo antimalarial activities against blood stages of plasmodium. | 4-(tert-butyl)-2-((tert-butylamino)methyl)-6-(6-(trifluoromethyl)pyridin-3-yl)-phenol (jpc-2997) is a new aminomethylphenol compound that is highly active in vitro against the chloroquine-sensitive d6, the chloroquine-resistant w2, and the multidrug-resistant tm90-c2b plasmodium falciparum lines, with 50% inhibitory concentrations (ic50s) ranging from 7 nm to 34 nm. jpc-2997 is >2,500 times less cytotoxic (ic50s > 35 μm) to human (hepg2 and hek293) and rodent (bhk) cell lines than the d6 parasit ... | 2015 | 25331702 |
| a review of plasmodium coatneyi-macaque models of severe malaria. | malaria remains one of the most significant public health concerns in the world today. approximately half the human population is at risk for infection, with children and pregnant women being most vulnerable. more than 90% of the total human malaria burden, which numbers in excess of 200 million annually, is due to plasmodium falciparum. lack of an effective vaccine and a dwindling stockpile of antimalarial drugs due to increased plasmodial resistance underscore the critical need for valid anima ... | 2015 | 26077782 |
| cheminformatics based machine learning models for ama1-ron2 abrogators for inhibiting plasmodium falciparum erythrocyte invasion. | malaria remains a dreadful disease by putting every year about 3.4 billion people at risk and resulting into mortality of 627 thousand people worldwide. existing therapies based upon quinines and artemisinin-based combination therapies have started showing resistance, pressing the need for search of anti-malarials with different mechanisms of action. in this respect erythrocyte invasion by plasmodium is immensely crucial, as being obligate intracellular parasite it must invade host cells. this p ... | 2015 | 27490966 |
| contribution of polymerase chain reaction for detection of malaria in tunisia. | in tunisia, detection of plasmodium in asymptomatic individuals from endemic countries is a critical measure in national program of malaria eradication. the screening is based on microscopic examination of thick and thin blood smears. however, the performance of this diagnosis is closely related to the experience of biologist and the parasitaemia. | 2015 | 27249386 |
| field performance of malaria rapid diagnostic test for the detection of plasmodium falciparum infection in odisha state, india. | rapid diagnostic tests (rdts) have become an essential surveillance tool in the malaria control programme in india. the current study aimed to assess the performance of parahit-f, a rapid test in diagnosis of plasmodium falciparum infection through detecting its specific antigen, histidine rich protein 2 (pfhrp-2), in odisha state, india. | 2015 | 26905242 |
| antimalarial efficacy of albizia lebbeck (leguminosae) against plasmodium falciparum in vitro & p. berghei in vivo. | albizia lebbeck benth. (leguminosae) has long been used in indian traditional medicine. the current study was designed to test antimalarial activity of ethanolic bark extract of a. lebbeck (ebeal). | 2015 | 26905234 |
| discovery of pyridyl-based inhibitors of plasmodium falciparum n-myristoyltransferase. | n-myristoyltransferase (nmt) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. scaffold simplification from previously reported inhibitors containing bicyclic cores identified phenyl derivative 3, providing a versatile platform to study the effects of substitution on the scaffold, which yielded pyridyl 19. this molecule exhibited improved enzyme and cellular potency, and reduced ... | 2015 | 26962430 |
| increased synapsin i expression in cerebral malaria. | synapsin i is a neuronal phosphoprotein contained in the synaptic vesicles of mammalian central and peripheral nervous systems. it regulates both neurotransmitter release and synaptic formation. variations in synapsin i expression in the brain have been reported to cause brain malfunction. in severe malaria, neurological complications, such as convulsion, delirium and coma, suggest abnormalities in the release of neurotransmitters. this study evaluated synapsin i expression in cerebral malaria ( ... | 2015 | 26823711 |
| protein profiling of mefloquine resistant plasmodium falciparum using mass spectrometry-based proteomics. | malaria is a mosquito borne infectious disease caused by protozoa of genus plasmodium. there are five species of plasmodium that are found to infect humans. plasmodium falciparum can cause severe malaria leading to higher morbidity and mortality of malaria than the other four species. antimalarial resistance is the major obstacle to control malaria. mefloquine was used in combination with artesunate for uncomplicated p. falciparum in south east asia and it has developed and established mefloquin ... | 2015 | 26869851 |
| malarial pancreatitis: case report and systematic review of the literature. | malaria can cause a wide spectrum of clinical manifestations ranging from uncomplicated febrile illness to multiorgan failure. pancreatitis is a rare complication of malaria with only a few reported cases. herein, we describe a case of acute pancreatitis with multiorgan failure due to plasmodium falciparum managed successfully with antimalarials and conservative treatment. we also perform a systematic review of literature for reports of acute pancreatitis due to plasmodium infection. | 2015 | 26816452 |
| kinetic mechanism of plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. | plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase (pfhgxprt) exhibits a kinetic mechanism that differs from that of the human homolog. human hgprt follows a steady-state ordered mechanism, wherein prpp binding precedes the binding of hypoxanthine/guanine and release of product imp/gmp is the rate limiting step. in the current study, initial velocity kinetics with pfhgxprt indicates a steady-state ordered mechanism, wherein xanthine binding is conditional to the bindin ... | 2015 | 26902413 |
| [research progress on artemisinin resistance in plasmodium falciparum]. | artemisinin (art) is a novel and effective antimalarial drug discovered in china. as recommended by the world health organization, the art-based combination therapies (acts) have become the first-line drugs for the treatment of falciparum malaria. art and its derivatives have contributed greatly to the effective control of malaria globally, leading to yearly decrease of malaria morbidity and mortality. however, there have recently been several reports on the resistance of plasmodium falciparum t ... | 2015 | 27089770 |
| plasmodium ispd (2-c-methyl-d-erythritol 4-phosphate cytidyltransferase), an essential and druggable antimalarial target. | as resistance to current therapies spreads, novel antimalarials are urgently needed. in this work, we examine the potential for therapeutic intervention via the targeting of plasmodium ispd (2-c-methyl-d-erythritol 4-phosphate cytidyltransferase), the second dedicated enzyme of the essential methylerythritol phosphate (mep) pathway for isoprenoid biosynthesis. enzymes of this pathway represent promising therapeutic targets because the pathway is not present in humans. the malaria box compound, m ... | 2015 | 26783558 |
| new concepts in malaria pathogenesis: the role of the renin-angiotensin system. | malaria is a worldwide health problem leading the death of millions of people. the disease is induced by different species of protozoa parasites from the genus plasmodium. in humans, plasmodium falciparum is the most dangerous species responsible for severe disease. despite all efforts to establish the pathogenesis of malaria, it is far from being fully understood. in addition, resistance to existing drugs has developed in several strains and the development of new effective compounds to fight t ... | 2015 | 26779452 |
| dynamics of bacterial community composition in the malaria mosquito's epithelia. | the anopheles midgut hosts diverse bacterial communities and represents a complex ecosystem. several evidences indicate that mosquito midgut microbiota interferes with malaria parasite transmission. however, the bacterial composition of salivary glands and ovaries, two other biologically important tissues, has not been described so far. in this study, we investigated the dynamics of the bacterial communities in the mosquito tissues from emerging mosquitoes until 8 days after a blood meal contain ... | 2015 | 26779155 |
| the cytoplasmic region of plasmodium falciparum surfin4.2 is required for transport from maurer's clefts to the red blood cell surface. | plasmodium, the causative agent of malaria, exports many proteins to the surface of the infected red blood cell (irbc) in order to modify it toward a structure more suitable for parasite development and survival. one such exported protein, surfin4.2, from the parasite of human malignant malaria, p. falciparum, was identified in the trypsin-cleaved protein fraction from the irbc surface, and is thereby inferred to be exposed on the irbc surface. surfin4.2 also localize to maurer's clefts-parasite ... | 2015 | 26865830 |
| ketolide agents hmr 3004 and hmr 3647 (telithromycin) inhibit the growth of plasmodium falciparum in vitro. | malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations. ketolides antibiotics are used for treatment of various ailments and are relevant candidates to establish antiparasitic activity. | 2015 | 26958030 |
| antiplasmodial activity of some phenolic compounds from cameroonians allanblackia. | plasmodium falciparum, one of the causative agents of malaria, has high adaptability through mutation and is resistant to many types of anti-malarial drugs. this study presents an in vitro assessment of the antiplasmodial activity of some phenolic compounds isolated from plants of the genus allanblackia. | 2015 | 26957972 |
| severe malaria in immigrant haematological patient. | severe malaria is a life-threatening condition caused by plasmodium falciparum. rupture of red blood cells when merozoites release to the bloodstream is responsible for the clinical manifestations, febrile fever reaching 39 °c, and other unspecific symptoms. p. falciparum is considered as the worst form of malaria. moreover, this species has cytoadherence to red blood cells. this can lead to an organic dysfunction. people coming from hyper endemic areas have developed a partial immunity, but imm ... | 2015 | 26793463 |
| homology-based prediction of potential protein-protein interactions between human erythrocytes and plasmodium falciparum. | plasmodium falciparum, a causative agent of malaria, is a well-characterized obligate intracellular parasite known for its ability to remodel host cells, particularly erythrocytes, to successfully persist in the host environment. however, the current levels of understanding from the laboratory experiments on the host-parasite interactions and the strategies pursued by the parasite to remodel host erythrocytes are modest. several computational means developed in the recent past to predict host-pa ... | 2015 | 26740742 |
| electrolyte disturbance and the type of malarial infection. | electrolytes play an important role in the normal functioning of human body. electrolyte imbalance and mineral disturbances is the common clinical manifestation in several infectious diseases including malaria. malaria is a mosquito borne serious infectious disease of the world. plasmodium vivax and p. falciparum are the main agents responsible for malaria in pakistan. electrolyte imbalance in malarial infection may lead towards the severity of disease. | 2015 | 26744706 |