Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| design, synthesis, and antibacterial activity of demethylvancomycin analogues against drug-resistant bacteria. | five novel n-substituted demethylvancomycin derivatives were rationally designed and synthesized by using a structure-based approach. the in vitro antibacterial activities against methicillin-resistant staphylococcus aureus (mrsa), gentamicin-resistant enterococcus faecalis (gre), methicillin-resistant streptococcus pneumoniae (mrs), and vancomycin-resistant enterococcus faecalis (vre) were evaluated. one of the compounds, n-(6-phenylheptyl)demethylvancomycin (12 a), was found to exhibit more po ... | 2013 | 23576378 |
| pyelonephritis: what are the present day causative organisms and antibiotic susceptibilities? | infections of the lower urinary tract and acute pyelonephritis are commonly encountered in clinical practice. widespread usage of antibiotics and changing susceptibility profiles of uropathogens requires regular review of treatment guidelines to meet these challenges. we aimed to better understand the prevalence of uropathogens and emerging antibiotic resistance in patients with pyelonephritis requiring hospital admission. | 2013 | 23573984 |
| insidious onset of tetraparesis due to cervical epidural abscess from enterococcus faecalis. | we report a case of cervical epidural abscess from enterococcus faecalis, which caused an insidious onset of tetraparesis. this 53-year-old female with a history of diabetes mellitus and chronic renal failure under hemodialysis presented with pain and progressive weakness of upper and lower extremities without fever. although a recent mri she did at the beginning of symptoms showed no significant pathologies, except for a cervical disc herniation and adjacent spinal degeneration, and stenosis th ... | 2013 | 23573096 |
| antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. | conjugation is one of the most common ways bacteria acquire antibiotic resistance, contributing to the emergence of multidrug-resistant "superbugs." bacteria of the genus enterococcus faecalis are highly antibiotic-resistant nosocomial pathogens that use the mechanism of conjugation to spread antibiotic resistance between resistance-bearing donor cells and resistance-deficient recipient cells. here, we report a unique quorum sensing-based communication system that uses two antagonistic signaling ... | 2013 | 23569272 |
| comparison of the risk of microbiological contamination between samples of breast milk obtained at home and at a healthcare facility. | breast milk is the best food for preterm infants. due to their inadequate suction- swallowing action, the administration of expressed breast milk should be done with an orogastric tube. there is little information available regarding the microbiological safety of expressed breast milk. the aim of this article was to evaluate if there were any differences regarding the contamination of breast milk obtained at a healthcare facility versus at home. | 2013 | 23568067 |
| influence of reciprocating single-file and rotary instrumentation on bacterial reduction on infected root canals. | to compare the bacterial reduction achieved with reciprocating and rotary systems during root canal preparation. | 2013 | 23566213 |
| response of e. faecalis biofilms to different associations of auxiliary substances during root canal preparation: a confocal laser microscopy analysis. | this in vitro study evaluated the effect of different endodontic auxiliary chemical substances over enterococcus faecalis (ef) biofilm through confocal laser scanning microscopy (clsm). | 2013 | 23564394 |
| rapid induction of an immune response in rat peyer's patch after oral administration of enterococcus faecalis strain ec-12. | a rapid and sharp immune response induced in peyer's patches (pps) by a single gavage of a heat-killed enterococcus faecalis strain ec-12 (ec-12) was demonstrated. ec-12 was observed inside the pps 2.5 h post administration and induction of tnf-α and cd69 gene expression was observed at the same time. the immune response in pps disappeared 24 h post administration. | 2013 | 23563541 |
| comparison of enterococcus faecium and enterococcus faecalis strains isolated from water and clinical samples: antimicrobial susceptibility and genetic relationships. | enterococci are part of the normal intestinal flora in a large number of mammals, and these microbes are currently used as indicators of fecal contamination in water and food for human consumption. these organisms are considered one of the primary causes of nosocomial and environmental infections due to their ability to survive in the environment and to their intrinsic resistance to antimicrobials. the aims of this study were to determine the biochemical patterns and antimicrobial susceptibiliti ... | 2013 | 23560050 |
| [analysis of antimicrobial effect of mtad solution in infected root canal system using pcr technique]. | clinically acceptable antiseptic should possess organolithic-mineralolithic properties and antimicrobial efficacy, and should be non-toxic. | 2013 | 23745336 |
| drosophila host model reveals new enterococcus faecalis quorum-sensing associated virulence factors. | enterococcus faecalis v583 is a vancomycin-resistant clinical isolate which belongs to the hospital-adapted clade, cc2. this strain harbours several factors that have been associated with virulence, including the fsr quorum-sensing regulatory system that is known to control the expression of gele and spre proteases. to discriminate between genes directly regulated by fsr, and those indirectly regulated as the result of protease expression or activity, we compared gene expression in isogenic muta ... | 2013 | 23734216 |
| influence of lactic acid bacteria on redox status and on proteolytic activity of buckwheat (fagopyrum esculentum moench) sourdoughs. | redox potential and proteolysis determine protein networks in doughs and thus dough rheology as well as the structure of baked goods. namely, gluten-free bakery products needs structural improvements but little is known about these parameters in gluten free dough systems. in this work the influence of lactic acid bacteria (lab) on redox status and proteolysis of buckwheat sourdoughs was investigated. an increase of free thiol groups was detected as redox potential was decreasing during fermentat ... | 2013 | 23728431 |
| antimicrobial susceptibility of organisms causing community-acquired urinary tract infections in gauteng province, south africa. | patients with community-acquired urinary tract infections (utis) frequently present to healthcare facilities in south africa (sa). | 2013 | 23725955 |
| solution structures of the linear leaderless bacteriocins enterocin 7a and 7b resemble carnocyclin a, a circular antimicrobial peptide. | leaderless bacteriocins are a class of ribosomally synthesized antimicrobial peptides that are produced by certain gram-positive bacteria without an n-terminal leader section. these bacteriocins are of great interest due to their potent inhibition of many gram-positive organisms, including food-borne pathogens such as listeria and clostridium spp. we now report the nmr solution structures of enterocins 7a and 7b, leaderless bacteriocins recently isolated from enterococcus faecalis 710c. these ar ... | 2013 | 23725536 |
| antibacterial effect of diclofenac sodium on enterococcus faecalis. | non-steroidal anti-inflammatory drugs (nsaids) have shown antibacterial activity in some recent studies. the aim of this study was to evaluate the antibacterial effect of diclofenac against enterococcus faecalis (e. faecalis) as a resistant endodontic bacterium in comparison with ibuprofen, calcium hydroxide and amoxicillin. | 2013 | 23724199 |
| engineering solutions to improve the removal of fecal indicator bacteria by bioinfiltration systems during intermittent flow of stormwater. | bioinfiltration systems facilitate the infiltration of urban stormwater into soil and reduce high flow events and flooding. stormwater carries a myriad of pollutants including fecal indicator bacteria (fib). significant knowledge gaps exist about the ability of bioinfiltration systems to remove and retain fib. the present study investigates the ability of model, simplified bioinfiltration systems containing quartz sand and iron oxide-coated quartz sand (iocs) to remove two fib (enterococcus faec ... | 2013 | 23721343 |
| epidemiology of urinary tract infection among spinal cord injured patients in rehabilitation ward at siriraj hospital. | a prophylactic antibiotic in retrograde investigations (ix) such as an urodynamic study was suggested by the european association of urology in order to prevent urinary tract infection (uti) in the neurogenic bladder however finding an appropriate antibiotic is questionable since bacterial types and their sensitivities are variable in different settings. therefore, the present study was aimed to find out the epidemiology of uti in spinal cord injured (sci) patients within the rehabilitation ward ... | 2013 | 23720985 |
| partial purification and characterization of a bacteriocin dt24 produced by probiotic vaginal lactobacillus brevis dt24 and determination of its anti-uropathogenic escherichia coli potential. | the emergence of antibiotic resistance has increased the interest for finding new antimicrobials in the past decade. probiotic lactic acid bacteria producing antimicrobial proteins like bacteriocin can be excellent agents for development as novel therapeutic agents and complement to conventional antibiotic therapy. uropathogenic escherichia coli, most causative agent of urinary tract infection, has developed resistance to various antibiotics. in the present investigation, antibacterial substance ... | 2013 | 26782739 |
| regulation of the activity of lactate dehydrogenases from four lactic acid bacteria. | despite high similarity in sequence and catalytic properties, the l-lactate dehydrogenases (ldhs) in lactic acid bacteria (lab) display differences in their regulation that may arise from their adaptation to different habitats. we combined experimental and computational approaches to investigate the effects of fructose 1,6-bisphosphate (fbp), phosphate (pi), and ionic strength (nacl concentration) on six ldhs from four labs studied at ph 6 and ph 7. we found that 1) the extent of activation by f ... | 2013 | 23720742 |
| an in vitro evaluation of the antimicrobial efficacy of curcuma longa, tachyspermum ammi, chlorhexidine gluconate, and calcium hydroxide on enterococcus faecalis. | this in vitro study was designed to comparatively evaluate the antimicrobial efficacy of curcuma longa (turmeric - t1-10%, t2-20%); tachyspermum ammi (ajwain - a1-10%, a2-20%); chlorhexidine (chx) gluconate gel (hexigel - 1%); and calcium hydroxide (10%) as intracanal medicaments against enterococcus faecalis. | 2013 | 23716967 |
| gassericin a: a circular bacteriocin produced by lactic acid bacteria lactobacillus gasseri. | during the recent years extensive efforts have been made to find out bacteriocins from lactic acid bacteria (lab) active against various food spoilage and pathogenic bacteria, and superior stabilities against heat treatments and ph variations. bacteriocins isolated from lab have been grouped into four classes. circular bacteriocins which were earlier grouped among the four groups of bacteriocins, have recently been proposed to be classified into a different class, making it class v bacteriocins. ... | 2013 | 23712477 |
| de novo assembly and comparative analysis of the enterococcus faecalis genome (kacc 91532) from a korean neonate. | using a newly constructed de novo assembly pipeline, finished genome level assembly had been conducted for the probiotic candidate strain e. faecalis kacc 91532 isolated from a stool samples of korean neonates. our gene prediction identified 3,061 genes in the assembled genome of the strain. among these, nine genes were specific only for the e. faecalis kacc 91532, compared with all of the four known reference genomes (ef62, d32, v583, og1rf). we identified genes related to phenotypic characters ... | 2013 | 23711517 |
| ciprofloxacin resistance in enterococcus faecalis strains isolated from male patients with complicated urinary tract infection. | urinary tract infection (uti) is one of the most prevalent bacterial infections, and fluoroquinolone therapy is a well-known standard regimen for uti. the prevalence and risk factor analysis of fluoroquinolone resistance in enterococcal utis are not well documented. the aim of this study was to evaluate the antimicrobial susceptibility and risk factors for ciprofloxacin resistance in enterococcus faecalis strains isolated from patients with complicated uti. | 2013 | 23789048 |
| ex-vivo effect of intracanal medications based on ozone and calcium hydroxide in root canals contaminated with enterococcus faecalis. | this ex vivo study evaluated the antibacterial effect of intracanal medications in root canals contaminated with enterococcus faecalis. fifty single-rooted human teeth were contaminated with e. faecalis (atcc 29212) and incubated at 37°c for 21 days. the specimens were randomly divided into 5 groups according to the intracanal medication used: oz-pg: ozonized propylene glycol; ch/cpmc: calcium hydroxide/camphorated paramonochlorophenol; oz-pg/ch ozonized pg/ch; pc: positive control group (no med ... | 2013 | 23780354 |
| epidemiology and prognostic determinants of bacteraemic catheter-acquired urinary tract infection in a single institution from 1991 to 2010. | to determine the epidemiology of bacteraemic catheter-acquired urinary tract infection (ca-uti) and to identify independent predictors of mortality. | 2013 | 23774535 |
| multicenter study of high-dose daptomycin for treatment of enterococcal infections. | enterococci are among the leading pathogens isolated in hospital-acquired infections. current antimicrobial options for vancomycin-resistant enterococci (vre) are limited. prior data suggest that daptomycin at >6 mg/kg of body weight/day may be used to treat enterococcal infections. we retrospectively evaluated the effectiveness and safety of high-dose daptomycin (hd-daptomycin) therapy (>6 mg/kg) in a multicenter cohort of adult patients with enterococcal infections to describe the characterist ... | 2013 | 23774437 |
| antimicrobial activity of binary combinations of natural and synthetic phenolic antioxidants against enterococcus faecalis. | this study investigated the antimicrobial activity of 3 natural (thymol, carvacrol, and gallic acid) and 2 synthetic [butylated hydroxyanisole (bha) and octyl gallate] phenolic compounds, individually and in binary combinations, on 4 dairy isolates of enterococcus faecalis with different virulence factors (β-hemolytic, gelatinase, or trypsin activities; acquired resistance to erythromycin or tetracycline; and natural resistance to gentamicin). a checkerboard technique and a microdilution standar ... | 2013 | 23769374 |
| identification, biochemical and structural evaluation of species-specific inhibitors against type i methionine aminopeptidases. | methionine aminopeptidases (metaps) are essential enzymes that make them good drug targets in cancer and microbial infections. metaps remove the initiator methionine from newly synthesized peptides in every living cell. metaps are broadly divided into type i and type ii classes. both prokaryotes and eukaryotes contain type i metaps, while eukaryotes have additional type ii metap enzyme. although several inhibitors have been reported against type i enzymes, subclass specificity is scarce. here, u ... | 2013 | 23767698 |
| effect of er:yag laser-activated irrigation solution on enterococcus faecalis biofilm in an ex-vivo root canal model. | abstract objective: the purpose of this study was to evaluate mineral content and surface morphology of root canals coated with enterococcus faecalis biofilm after treatment with several endodontic irrigation solutions, with and without er:yag laser-activated irrigation (lai). | 2013 | 23763481 |
| multicenter clinical evaluation of vreselect agar for identification of vancomycin-resistant enterococcus faecalis and enterococcus faecium. | a chromogenic medium for identification of vancomycin-resistant enterococcus faecalis and enterococcus faecium, vreselect, was compared to bile esculin azide agar with 6 μg/ml vancomycin (beav) for the isolation of vancomycin-resistant enterococci (vre) from stool specimens. at 24 to 28 h, vreselect demonstrated 98.7% (confidence interval [ci], 96.1 to 99.7%) sensitivity and 99.0% (ci, 98.0 to 99.6%) specificity versus 85.1% (ci, 79.8 to 89.5%) and 90.1% (ci, 79.8 to 89.5%) sensitivity and speci ... | 2013 | 23761153 |
| preparation, characterization and antibacterial activity of poly(epsilon-caprolactone) electrospun fibers loaded with amoxicillin for controlled release in biomedical applications. | amoxicillin (amox) was successfully encapsulated at different concentrations into poly(epsilon-caprolactone) (pcl) by the electrospinning technique, and mats of non-woven fibers were obtained and characterized in terms of morphology, in vitro release and antibacterial properties. the scanning electron microscopy evidenced the nanofibrous structure of the pristine pcl, composed of individual, uniform, and randomly oriented fibres with an average diameter ranging around 0.8 micron. the addition of ... | 2013 | 23755579 |
| construction and potential application of controlled autolytic systems for lactobacillus casei in cheese manufacture. | the rapid release of intracellular enzymes into the curd by the autolysis of lactic acid bacteria starters is universally recognized as a critical biological process to accelerate cheese ripening. lactobacillus casei is typically the dominant nonstarter lactic acid bacterium in the ripening cheese. in this study, two controlled autolytic systems were established in l. casei bl23, based on the exploitation of the autolysins sourced from lactococcus lactis (acma) and enterococcus faecalis (atla). ... | 2013 | 23834793 |
| dentinal tubule disinfection with 2% chlorhexidine, garlic extract, and calcium hydroxide against enterococcus faecalis by using real-time polymerase chain reaction: in vitro study. | to compare the efficacy of garlic extract with 2% chlorhexidine (chx) and calcium hydroxide ca(oh)2 in disinfection of dentinal tubules contaminated with enterococcus faecalis by using real-time polymerase chain reaction (pcr). | 2013 | 23833449 |
| fitness costs of various mobile genetic elements in enterococcus faecium and enterococcus faecalis. | to determine the fitness effects of various mobile genetic elements (mges) in enterococcus faecium and enterococcus faecalis when newly acquired. we also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory. | 2013 | 23833178 |
| effects of photodynamic therapy on gram-positive and gram-negative bacterial biofilms by bioluminescence imaging and scanning electron microscopic analysis. | the aim of this study was to test photodynamic therapy (pdt) as an alternative approach to biofilm disruption on dental hard tissue, we evaluated the effect of methylene blue and a 660 nm diode laser on the viability and architecture of gram-positive and gram-negative bacterial biofilms. | 2013 | 23822168 |
| high genetic diversity of enterococcus faecium and enterococcus faecalis clinical isolates by pulsed-field gel electrophoresis and multilocus sequence typing from a hospital in malaysia. | little is known on the genetic relatedness and potential dissemination of particular enterococcal clones in malaysia. we studied the antibiotic susceptibility profiles of enterococcus faecium and enterococcus faecalis and subjected them to pulsed-field gel electrophoresis (pfge) and multilocus sequence typing (mlst). e. faecium and e. faecalis displayed 27 and 30 pulsotypes, respectively, and 10 representative e. faecium and e. faecalis isolates (five each) yielded few different sequence types ( ... | 2013 | 23819125 |
| lysins: the arrival of pathogen-directed anti-infectives. | lysins represent a novel class of anti-infectives derived from bacteriophage. lysins are bacterial cell-wall hydrolytic enzymes that selectively and rapidly kill (≥3 log c.f.u. in 30 min) specific gram-positive bacteria providing a targeted therapeutic approach with minimal impact on unrelated commensal flora. the potential for bacterial resistance to lysins is considered low due to targeting of highly conserved peptidoglycan components. through cutting-edge genetic engineering, lysins can be as ... | 2013 | 23813275 |
| relapsing endocarditis caused by enterococcus faecalis forming small colony variants. | small colony variants (scvs) are subpopulations of a bacterial strain that differ in morphology, growth rate, metabolism, and antibiotic sensitivity from the parent line. they are associated with chronic and difficult-to-treat infections. scv endocarditis is very rare and usually associated with intracardiac devices. herein, we report a case of endocarditis caused by scv-forming enterococcus faecalis that affected the native heart without any known predisposition. | 2013 | 23808721 |
| resistance mechanisms and epidemiology of multiresistant pathogens in europe and efficacy of tigecycline in observational studies. | antimicrobial drug resistance is a growing problem in europe and, even with differences in epidemiology, it is of great concern. the treatment of complicated skin and soft-tissue infections (csstis) and complicated intra-abdominal infections (ciais) is hindered further by pathogens that are resistant to methicillin, carbapenems, third-generation cephalosporins and glycopeptides. | 2013 | 23772046 |
| efficacy of tigecycline for the treatment of complicated intra-abdominal infections in real-life clinical practice from five european observational studies. | tigecycline is a broad-spectrum antibiotic approved for the treatment of complicated intra-abdominal infections (ciais). the efficacy of tigecycline when administered as monotherapy or in combination with other antibacterials in the treatment of ciais in routine clinical practice is described. | 2013 | 23772043 |
| role of the mannose receptor in phagocytosis of enterococcus faecalis strain ec-12 by antigen-presenting cells. | the aim of this study was to clarify the phagocytic mechanisms of a heat-killed cell preparation of enterococcus faecalis strain ec-12 (ec-12) by antigen-presenting cells (apcs). fluorescein isothiocyanate (fitc)-labeled ec-12 was cocultured with peritoneal macrophage and the amount of ec-12 phagocytosed by peritoneal macrophages was measured using a microplate fluorometer. peritoneal macrophages from toll-like receptor (tlr)2-, tlr7-, and myd88-deficient knockout (ko) mice exhibited similar lev ... | 2013 | 23801521 |
| quantitative detection of staphylococcus aureus, enterococcus faecalis and pseudomonas aeruginosa in human oral epithelial cells from subjects with periodontitis and periodontal health. | epithelial cells in oral cavities can be considered reservoirs for a variety of bacterial species. a polymicrobial intracellular flora associated with periodontal disease has been demonstrated in buccal cells. important aetiological agents of systemic and nosocomial infections have been detected in the microbiota of subgingival biofilm, especially in individuals with periodontal disease. however, non-oral pathogens internalized in oral epithelial cells and their relationship with periodontal sta ... | 2013 | 23800598 |
| analysis of genetic lineages and their correlation with virulence genes in enterococcus faecalis clinical isolates from root canal and systemic infections. | enterococcus faecalis is a member of the mammalian gastrointestinal microbiota but has been considered a leading cause of hospital-acquired infections. in the oral cavity, it is commonly detected from root canals of teeth with failed endodontic treatment. however, little is known about the virulence and genetic relatedness among e. faecalis isolates from different clinical sources. this study compared the presence of enterococcal virulence factors among root canal strains and clinical isolates f ... | 2013 | 23791252 |
| antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines. | several phenyl substituted naphthalenes and isoquinolines have been identified as antibacterial agents that inhibit ftsz-zing formation. in the present study we evaluated the antibacterial of several phenyl substituted quinoxalines, quinazolines and 1,5-naphthyridines against methicillin-sensitive and methicillin-resistant staphylococcusaureus and vancomycin-sensitive and vancomycin-resistant enterococcusfaecalis. some of the more active compounds against s. aureus were evaluated for their effec ... | 2013 | 23891185 |
| direction of aminoacylated transfer rnas into antibiotic synthesis and peptidoglycan-mediated antibiotic resistance. | prokaryotic aminoacylated-transfer rnas often need to be efficiently segregated between translation and other cellular biosynthetic pathways. many clinically relevant bacteria, including streptococcus pneumoniae, staphylococcus aureus, enterococcus faecalis and pseudomonas aeruginosa direct some aminoacylated-trna species into peptidoglycan biosynthesis and/or membrane phospholipid modification. subsequent indirect peptidoglycan cross-linkage or change in membrane permeability is often a prerequ ... | 2013 | 23907010 |
| abundance and diversity of plasmid-associated genes among clinical isolates of enterococcus faecalis. | enterococcus faecalis, a normal compound of the human intestinal microbiome, plays an important role in hospital-acquired infections. plasmids make a significant contribution to the acquisition of the novel traits such as antimicrobial resistance and virulence by this pathogen. the study investigated the plasmid content and the diversity of plasmid-associated genes in a group of 152 hospital isolates of e. faecalis. the majority of plasmids visualized by pulsed-field gel electrophoresis of s1 nu ... | 2013 | 23906674 |
| presence of virulence factors in enterococcus faecalis and enterococcus faecium susceptible and resistant to vancomycin. | despite the increasing importance of enterococcus as opportunistic pathogens, their virulence factors are still poorly understood. this study determines the frequency of virulence factors in clinical and commensal enterococcus isolates from inpatients in porto alegre, brazil. fifty enterococcus isolates were analysed and the presence of the gele, asa1 and esp genes was determined. gelatinase activity and biofilm formation were also tested. the clonal relationships among the isolates were evaluat ... | 2013 | 23903974 |
| pcr and electrospray ionization mass spectrometry for detection of persistent enterococcus faecalis in cerebrospinal fluid following treatment of postoperative ventriculitis. | we describe the use of pcr and electrospray ionization followed by mass spectrometry (pcr/esi-ms) to evaluate "culture-negative" cerebrospinal fluid (csf) from a 67-year-old man who developed postoperative bacterial ventriculitis following a suboccipital craniotomy for resection of an ependymoma in the 4th ventricle. csf samples were obtained on seven occasions, beginning in the operating room at the time of insertion of a right ventriculoperitoneal shunt (vps) and continuing until his death, 6 ... | 2013 | 23903548 |
| high-throughput screening of inhibitors targeting agr/fsr quorum sensing in staphylococcus aureus and enterococcus faecalis. | staphylococcus aureus and enterococcus faecalis employ cyclic peptide-mediated quorum sensing (qs) systems, termed agr and fsr respectively, to regulate the expression of a series of virulence genes. to identify quorum sensing inhibitors (qsis) that target agr/fsr systems, an efficient screening system was established. in addition to the gelatinase-induction assay to examine e. faecalis fsr qs, the use of an s. aureus agr reporter strain that carries luciferase and green fluorescence protein gen ... | 2013 | 23649251 |
| analysis of the tolerance of pathogenic enterococci and staphylococcus aureus to cell wall active antibiotics. | tolerance refers to the phenomenon that bacteria do not significantly die when exposed to bactericidal antibiotics. enterococci are known for their high tolerance to these drugs, but the molecular reasons why they resist killing are not understood. in a previous study we showed that the superoxide dismutase (sod) is implicated in this tolerance. this conclusion was based on the results obtained with one particular strain of enterococcus faecalis and therefore the objective of the present communi ... | 2013 | 23649229 |
| redox balance via lactate dehydrogenase is important for multiple stress resistance and virulence in enterococcus faecalis. | enterococcus faecalis is a highly stress resistant opportunistic pathogen. the intrinsic ruggedness of this bacterium is supposed to be the basis of its capacity to colonize the hostile environments of hospitals and to cause several kinds of infections. we show in this work that general resistance to very different environmental stresses depends on the ability of e. faecalis to maintain redox balance via lactate dehydrogenase (ldh). furthermore, ldh-deficient mutants are less successful than the ... | 2013 | 23649090 |
| enterococcus faecalis prophage dynamics and contributions to pathogenic traits. | polylysogeny is frequently considered to be the result of an adaptive evolutionary process in which prophages confer fitness and/or virulence factors, thus making them important for evolution of both bacterial populations and infectious diseases. the enterococcus faecalis v583 isolate belongs to the high-risk clonal complex 2 that is particularly well adapted to the hospital environment. its genome carries 7 prophage-like elements (v583-pp1 to -pp7), one of which is ubiquitous in the species. in ... | 2013 | 23754962 |
| bacterial contamination of unused, disposable non-sterile gloves on a hospital orthopaedic ward. | non-sterile disposable gloves are used on large hospital wards, however their potential role as a vehicle for pathogen transmission has not been explored in this setting. | 2013 | 23837081 |
| genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins a, and pleuromutilins (lsap phenotype) in enterococcus faecium. | as opposed to enterococcus faecalis, which is intrinsically resistant to lincosamides, streptogramins a, and pleuromutilins (lsap phenotype) by production of the abc protein lsa(a), enterococcus faecium is naturally susceptible. since this phenotype may be selected for in vivo by quinupristin-dalfopristin (q-d), the aim of this study was to investigate the molecular mechanism of acquired lsap resistance in e. faecium. six lsap-resistant in vitro mutants of e. faecium hm1070 as well as three diff ... | 2013 | 23836170 |
| comparison of rosco neo-sensitabs with oxoid paper disks in eucast disk diffusion antimicrobial susceptibility testing on mueller-hinton agar. | this study compared neo-sensitabs with oxoid paper disks using the european committee on antimicrobial susceptibility testing (eucast) disk diffusion antimicrobial susceptibility test on mueller-hinton agar. the eucast-recommended quality control strains (escherichia coli atcc 25922, pseudomonas aeruginosa atcc 27853, staphylococcus aureus atcc 29213 and enterococcus faecalis atcc 29212) (part i) and clinical isolates (part ii) were investigated. in part i of the study, 27 combinations of antimi ... | 2013 | 23232977 |
| cold plasma therapy of a tooth root canal infected with enterococcus faecalis biofilms in vitro. | complete sterilization of an infected root canal is an important challenge in endodontic treatment. traditional methods often cannot achieve high-efficiency sterilization because of the complexity of the root canal system. the objective of the study was to investigate in vitro the feasibility of using a cold plasma treatment of a root canal infected with enterococcus faecalis biofilms. | 2013 | 23228267 |
| streptococcus gordonii collagen-binding domain protein cbda may enhance bacterial survival in instrumented root canals ex vivo. | the surface-associated collagen-binding protein ace of enterococcus faecalis has been implicated as a virulence factor that contributes to bacterial persistence in endodontic infections. the purpose of this study was to determine if proteins with amino acid sequence similarity to ace found in more abundant oral streptococci could play a similar role in potentially enhancing endodontic infections. | 2013 | 23228255 |
| detection and enumeration of e. coli o157:h7 in water samples by culture and molecular methods. | the performances of three chromogenic agars were evaluated for the recovery of escherichia coli o157:h7 from spiked dechlorinated tap, ground and surface water, and treated drinking water samples. the chromogenic agars: chromagar o157 (chrom), rainbow agar o157 (rb) and hicrome ec o157 (hc) were compared to cefixime-tellurite sorbitol macconkey (ct-smac), commonly used for the isolation of e. coli o157:h7. confirmation of suspect e. coli o157:h7 colonies were performed by colony real-time pcr (c ... | 2013 | 23220187 |
| twenty-five years of shared life with vancomycin-resistant enterococci: is it time to divorce? | twenty-five years ago, isolation of vancomycin-resistant enterococcus faecium (vrem) was reported both in the uk and in france. since then, vrem has spread worldwide in hospitals. hospital outbreaks appeared to be related to the evolution since the end of 1980s of a subpopulation of e. faecium highly resistant to ampicillin and fluoroquinolones (the so-called clonal complex cc17) that later acquired resistance to vancomycin. cc17 isolates are presumably better adapted than other e. faecium isola ... | 2013 | 23208830 |
| characterization of recombinant fad-independent catabolic acetolactate synthase from enterococcus faecalis v583. | the catabolic acetolactate synthase (cals) of enterococcus faecalis v583 was cloned, expressed in escherichia coli, and purified to homogeneity. the purified protein had a molecular weight of 60 kda. the cals of e. faecalis is highly homologous with other calss, while sharing low homology with its anabolic counterparts. the cals of e. faecalis exhibits optimum activity at a temperature of 37°c and ph 6.8. based on the enzyme characterization, the apparent k(m) for pyruvate was calculated to be 1 ... | 2013 | 23199739 |
| the efficacy of sequential therapy using pazufloxacin followed by oral fluoroquinolones for treatment of pyelonephritis. | the efficacy of sequential therapy of pazufloxacin (pzfx), which is a parenteral fluoroquinolone, followed by oral fluoroquinolones [tosufloxacin tosilate (tflx) or levofloxacin (lvfx)] for treatment of pyelonephritis, was evaluated. patients with pyelonephritis who had fever (≥37.5 °c), pyuria (≥10 white blood cells/high-power field), and bacteriuria (≥10(4) colony-forming units/ml) were eligible for this study. pzfx (500 mg) was given intravenously twice a day for at least 3 days. if the patie ... | 2013 | 23188166 |
| glucose triggers atp secretion from bacteria in a growth-phase-dependent manner. | atp modulates immune cell functions, and atp derived from gut commensal bacteria promotes the differentiation of t helper 17 (th17) cells in the intestinal lamina propria. we recently reported that enterococcus gallinarum, isolated from mice and humans, secretes atp. we have since found and characterized several atp-secreting bacteria. of the tested enterococci, enterococcus mundtii secreted the greatest amount of atp (>2 μm/10(8) cells) after overnight culture. glucose, not amino acids and vita ... | 2013 | 23354720 |
| independent risk factors for the co-colonization of vancomycin-resistant enterococcus faecalis and methicillin-resistant staphylococcus aureus in the region most endemic for vancomycin-resistant staphylococcus aureus isolation. | in the majority of cases of vancomycin-resistant staphylococcus aureus (vrsa), vancomycin-resistant enterococcus faecalis (vr e. faecalis) served as the vana donor to s. aureus. previous studies that evaluated the risk factors for co-colonization with vre and mrsa did not differentiate between vr e. faecalis and vr e. faecium. this study aimed to identify variables associated with vr e. faecalis and mrsa co-colonization. a retrospective case-control study from january 2008 to december 2009 was c ... | 2013 | 23354672 |
| the antibacterial activity of sodium hypochlorite and chlorhexidine against enterococcus faecalis: a review on agar diffusion and direct contact methods. | complete debridement and disinfection of the root canal system are fundamental requirements for successful endodontic treatment. despite the morphological challenges of the internal root anatomy, root canal irrigants play an important role in the optimization of the root canal preparation, which is essentially a chemo-mechanical procedure. enterococcus faecalis is one of the most resistant microorganisms that dominants the microbial ecosystem of persistent periradicular lesions in retreatment ca ... | 2013 | 23349569 |
| antimicrobial activity, antibiotic susceptibility and virulence factors of lactic acid bacteria of aquatic origin intended for use as probiotics in aquaculture. | the microorganisms intended for use as probiotics in aquaculture should exert antimicrobial activity and be regarded as safe not only for the aquatic hosts but also for their surrounding environments and humans. the objective of this work was to investigate the antimicrobial/bacteriocin activity against fish pathogens, the antibiotic susceptibility, and the prevalence of virulence factors and detrimental enzymatic activities in 99 lactic acid bacteria (lab) (59 enterococci and 40 non-enterococci ... | 2013 | 23347637 |
| tn6198, a novel transposon containing the trimethoprim resistance gene dfrg embedded into a tn916 element in listeria monocytogenes. | to characterize tn6198, a novel conjugative transposon from the clinical listeria monocytogenes strain tth-2007, which contains the tetracycline and trimethoprim resistance genes tet(m) and dfrg, respectively, and to assess its transferability in vitro and in situ. | 2013 | 23344576 |
| biosorption and biodegradation of acid orange 7 by enterococcus faecalis strain zl: optimization by response surface methodological approach. | reactive dyes account for one of the major sources of dye wastes in textile effluent. in this study, decolorization of the monoazo dye, acid orange 7 (ao7) by the enterococcus faecalis strain zl that isolated from a palm oil mill effluent treatment plant has been investigated. decolorization efficiency of azo dye is greatly affected by the types of nutrients and the size of inoculum used. in this work, one-factor-at-a-time (method and response surface methodology (rsm) was applied to optimize th ... | 2013 | 23334551 |
| antioxidant and antimicrobial activities of 7-hydroxy-calamenene-rich essential oils from croton cajucara benth. | croton cajucara is a shrub native to the amazon region locally known as "sacaca". two morphotypes are known: white and red "sacaca". the essential oils (eo) obtained by hydrodistillation from leaves of the red morphotype were, in general, rich in 7-hydroxycalamenene (28.4%-37.5%). the effectiveness of these eo regarding the antimicrobial activity against pathogenic microorganisms was initially investigated by the drop test method, showing significant inhibition zones. among the microorganisms te ... | 2013 | 23325101 |
| cyclooxygenase-2 generates the endogenous mutagen trans-4-hydroxy-2-nonenal in enterococcus faecalis-infected macrophages. | infection of macrophages by the human intestinal commensal enterococcus faecalis generates dna damage and chromosomal instability in mammalian cells through bystander effects. these effects are characterized by clastogenesis and damage to mitotic spindles in target cells and are mediated, in part, by trans-4-hydroxy-2-nonenal (4-hne). in this study, we investigated the role of cox and lipoxygenase (lox) in producing this reactive aldehyde using e. faecalis-infected macrophages and interleukin (i ... | 2013 | 23321929 |
| polymicrobial endocarditis: chronic q fever and enterococcus faecalis coinfection. | 2013 | 23318110 | |
| biofilm biomass disruption by natural substances with potential for endodontic use. | this study evaluated the in vitro effects of four natural substances on the biomass of bacterial biofilms to assess their potential use as root canal irrigants. the following substances and their combinations were tested: 0.2% farnesol; 5% xylitol; 20% xylitol; 0.2% farnesol and 5% xylitol; 0.2% farnesol, 5% xylitol, and 0.1% lactoferrin; 5% xylitol and 0.1% lactoferrin; and 20 mm salicylic acid. the crystal violet assay was used to evaluate the effects of these substances on the biomass of biof ... | 2013 | 23306623 |
| in vitro activity of telavancin and comparators against selected groups of gram-positive cocci. | telavancin is a novel, rapidly cidal, dual-action glycopeptide. this study examined its in vitro activity against relevant gram-positive pathogens, comprising 99 meticillin-resistant staphylococcus aureus (mrsa), 40 meticillin-susceptible s. aureus (mssa), 79 coagulase-negative staphylococci (cons), 45 enterococcus faecalis, 60 enterococcus faecium, 40 β-haemolytic streptococci and 60 streptococcus pneumoniae. except with vana enterococci, telavancin mics were tightly clustered and unimodal. tel ... | 2013 | 23298432 |
| efar is a major regulator of enterococcus faecalis manganese transporters and influences processes involved in host colonization and infection. | metal ions, in particular manganese, are important modulators of bacterial pathogenicity. however, little is known about the role of manganese-dependent proteins in the nosocomial pathogen enterococcus faecalis, a major cause of bacterial endocarditis. the present study demonstrates that the dtxr/mntr family metalloregulator efar of e. faecalis controls the expression of several of its regulon members in a manganese-dependent way. we also show that efar inactivation impairs the ability of e. fae ... | 2013 | 23297382 |
| ex vivo killing of enterococcus faecalis and mixed plaque bacteria in planktonic and biofilm culture by modified photoactivated disinfection. | to compare the efficacy of conventional and modified photoactivated disinfection (pad) against enterococcus faecalis and mixed plaque bacteria in suspension and biofilms. | 2013 | 23289964 |
| development of a chemically defined medium for the production of enterolysin a from enterococcus faecalis b9510. | this study aimed to develop a simplified chemically defined medium that could sustain the growth and bacteriocin (enterolysin a) production by enterococcus faecalis b9510. | 2013 | 23279366 |
| efficiency of the intestinal bacteria in the degradation of the toxic pesticide, chlorpyrifos. | chlorpyrifos (cp) is the most commonly used pesticide throughout the world. its widespread use in agriculture and its potential toxicity to humans from ingestion of cp contaminated food have raised concerns about its risk to health. human intestinal microflora has the ability to degrade pesticides, but the exact mechanisms involved and the metabolite end-products formed are not well understood. the primary objective of this work was to analyse the in vitro degradation of cp by five model intesti ... | 2013 | 28324568 |
| molecular recognition of live methicillin-resistant staphylococcus aureus cells using dna aptamers. | to generate dna-aptamers binding to methicillin-resistant staphylococcus aureus (mrsa). | 2013 | 25436184 |
| oral administration of ec-12 increases the baseline gene expression of antiviral cytokine genes, ifn-γ and tnf-α, in splenocytes and mesenteric lymph node cells of weaning piglets. | weaning piglets are continuously exposed to various viruses. the antiviral effects of lactic acid bacteria (lab) have been confirmed mainly in humans and mice, while few studies have been conducted in livestock. in this study, we evaluated the effect of oral administration of enterococcus faecalis strain ec-12 (ec-12) on the gene expressions of antiviral cytokines in weaning piglets. piglets were allocated to the ec-12-administered group (e group) and the no-treatment control group (c group). th ... | 2013 | 24936371 |
| australian group on antimicrobial resistance enterococcus surveillance programme annual report, 2010. | in 2010, 15 institutions around australia conducted a period prevalence study of key resistances in isolates of enterococcus species associated with a range of clinical disease amongst in- and outpatients. each institution collected up to 100 consecutive isolates and tested these for susceptibility to commonly used antimicrobials using standardised methods. vancomycin-resistant enterococcus faecium and enterococcus faecalis were characterised by pulsed-field gel electrophoresis. multilocus seque ... | 2013 | 24890955 |
| an in vitro comparison of antimicrobial effcacy of three root canal irrigants-biopure mtad, 2% chlorhexidine gluconate and 5.25% sodium hypochlorite as a final rinse against e. faecalis. | this study was conducted to evaluate the antimicrobial activity of 5.25% sodium hypochlorite (naocl), 2% chlorhexidine (chx) and biopure mtad when used as a fnal rinse against enterococcus faecalis. | 2013 | 24685785 |
| phenotypic and molecular antibiotic resistance profile of enterococcus faecalis and enterococcus faecium isolated from different traditional fermented foods. | a collection of 55 enterococci (41 enterococcus faecium and 14 e. faecalis strains) isolated from various traditional fermented foodstuffs of both animal and vegetable origins, and water was evaluated for resistance against 15 antibiotics. lower incidence of resistance was observed with gentamicin, ampicillin, penicillin and teicoplanin. however, a high incidence of antibiotic resistance was detected for rifampicin (12 out of 14 of isolates), ciprofloxacin (9/14), and quinupristin/dalfopristin ( ... | 2013 | 23259502 |
| mutations in msra and msrb, encoding epimer-specific methionine sulfoxide reductases, affect expression of glycerol-catabolic operons in enterococcus faecalis differently. | this study aims to define the cellular roles of methionine sulfoxide reductases a and b, evolutionarily highly conserved enzymes able to repair oxidized methionines in proteins. msra and msrb mutants were exposed to an internal oxidative stress by growing them under aerobic conditions on glycerol. interestingly, the msr mutants behave completely differently under these conditions. the msra mutant is inhibited, whereas the msrb mutant is stimulated in its growth in comparison with the parent stra ... | 2013 | 23258264 |
| pseudo-outbreak of vancomycin-resistant-enterococcus (vre) colonization in a neonatal intensive care unit using spectra vre surveillance medium. | from november 2011 through march 2012, we surveyed 272 babies in our neonatal intensive care unit for rectal colonization with vancomycin-resistant enterococci (vre). using spectra vre medium (remel diagnostics, lenexa, ks), we identified one neonate colonized with vancomycin-resistant enterococcus faecium. in addition, 55 (13%) of the surveillance cultures yielded false-positive results with vancomycin-susceptible enterococcus faecalis. during the same time period, 580 rectal swabs were collect ... | 2013 | 23254135 |
| moxifloxacin as postoperative prophylaxis for enterococcus faecalis-induced endophthalmitis after cataract surgery in aphakic rabbits. | the development of endophthalmitis after cataract surgery often results in significant vision loss. inhibition of bacterial proliferation in the anterior chamber using antibiotic eye drops is important to prevent endophthalmitis after cataract surgery. we aimed to determine the sensitivity of fluoroquinolones against enterococcus faecalis ocular isolates and the efficacy of fluoroquinolones to prevent e. faecalis-induced endophthalmitis in aphakic rabbits. | 2013 | 23249386 |
| cost-effectiveness analysis, prevention of atopic dermatitis by oral application of bacterial lysate in newborns/small children. | the aim of this analysis was to determine the cost-effectiveness compared to placebo of prophylactic treatment with sterile bacterial lysate (escherichia coli and enterococcus faecalis) (verum) of newborns/small children with heredity for atopy [atopic dermatitis (ad)]. infants were followed from the age of 5 weeks until 3 years of age. during this time, the number of children with ad who were treated with verum or placebo was observed at eight visits. cost-effectiveness analyses were performed ... | 2013 | 23242758 |
| establishment of an optimized ex vivo system for artificial root canal infection evaluated by use of sodium hypochlorite and the photodynamic therapy. | to establish a refined model of artificially infected root canals and confirm its suitability as a sensitive ex vivo method to assess the efficacy of disinfecting agents. disinfection was evaluated using sodium hypochlorite (naocl), either blocked or unblocked by sodium thiosulphate, and a recently promoted method of disinfection, the antibacterial photodynamic therapy (pdt). | 2013 | 23240861 |
| identification of fitness determinants in enterococcus faecalis by differential proteomics. | enterococcus (e.) faecalis is found as commensal in healthy humans, in a variety of fermented foods. it can serve as probiotic but also as pathogen causing endocarditis, bacteremia and urinary tract infections. we have employed a proteomic study with e. faecalis strain og1rf under different growth conditions and in contact to mouse intestinal cells to identify novel latent and adaptive fitness determinants. these relate to changes in catabolic pathways (buda), protein biosynthesis (asns), cellul ... | 2013 | 23239053 |
| enterococcus faecalis internalization in human umbilical vein endothelial cells (huvec). | initial enterococcus faecalis-endothelial cell molecular interactions which lead to enterococci associating in the host endothelial tissue, colonizing it and proliferating there can be assessed using in vitro models. cultured human umbilical vein endothelial cells (huvec) have been used to study other gram-positive bacteria-cell interactions; however, few studies have been aimed at establishing the relationship of e. faecalis with endothelial cells. the aggregation substance (as) family of adhes ... | 2013 | 23174630 |
| presence of the vanc1 gene in a vancomycin-resistant enterococcus faecalis strain isolated from ewe bulk tank milk. | 2013 | 23161771 | |
| neonatal outcome of preterm infants born to mothers with abnormal genital tract colonisation and chorioamnionitis: a cohort study. | we hypothesised that abnormal genital tract colonisation leading to an in utero inflammation/infection process, contributes to the risk of respiratory distress syndrome (rds), patent ductus arteriosus (pda), intra ventricular haemorrhage (ivh), bronchopulmonary dysplasia (bpd), retinopathy of prematurity (rop) and necrotizing enterocolitis (nec) in preterm infants. | 2013 | 23158015 |
| [daptomycin for the treatment of gram-positive infections after cardiac surgery]. | surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. the aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. | 2013 | 23149592 |
| rapid identification of gram-positive pathogens and their resistance genes from positive blood culture broth using a multiplex tandem rt-pcr assay. | the early initiation of targeted antibiotic therapy in patients with bacteraemia and septic shock impacts favourably on outcomes. rapid methods are therefore increasingly employed for bacterial identification directly from positive blood culture bottles, but with variable success. we evaluated the performance of the gram positive 12 multiplex tandem pcr (mt-pcr) assay (ausdiagnostics; catalogue no. 6202, version 07) containing targets for the identification of staphylococci including staphylococ ... | 2013 | 23139396 |
| ex vivo antimicrobial efficacy of the endovac system plus photodynamic therapy associated with calcium hydroxide against intracanal enterococcus faecalis. | to evaluate the ex vivo efficacy of the endovac system and photodynamic treatment (pdt) as adjuncts to chemomechanical debridement associated with calcium hydroxide (caoh2 ) in reducing the levels of intracanal enterococcus faecalis. | 2013 | 23137292 |
| enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. | urinary catheterization elicits major histological and immunological changes that render the bladder susceptible to microbial invasion, colonization, and dissemination. however, it is not understood how catheters induce these changes, how these changes act to promote infection, or whether they may have any protective benefit. in the present study, we examined how catheter-associated inflammation impacts infection by enterococcus faecalis, a leading cause of catheter-associated urinary tract infe ... | 2013 | 23132492 |
| biochemical characterization of cardiolipin synthase mutations associated with daptomycin resistance in enterococci. | daptomycin (dap) resistance in enterococci has been linked to mutations in genes that alter the cell envelope stress response (cesr) (liafsr) and changes in enzymes that directly affect phospholipid homeostasis, and these changes may alter membrane composition, such as that of cardiolipin synthase (cls). while cls substitutions are observed in response to dap therapy, the effect of these mutations on cls activity remains obscure. we have expressed, purified, and characterized cls enzymes from bo ... | 2013 | 23114777 |
| evaluation of bacterial microleakage of root canals irrigated with different irrigation solutions and ktp laser system. | the aim of this study was to evaluate bacterial microleakage of the root canals irrigated with different irrigation solutions and the potassium-titanyl-phosphate (ktp) laser system and filled with gutta-percha and ah26 root canal sealer. in addition, the effect of the irrigation solutions on dentin surface was evaluated with a scanning electron microscope (sem). | 2013 | 23113510 |
| antimicrobial efficacy of cryotreatment against enterococcus faecalis in root canals. | the purpose of this investigation was to evaluate intracanal bacterial reduction by cryotreatment using a dental instrument equipped with a duct and connected to a cryogenic fluid source. a total of 86 roots were infected with enterococcus faecalis and incubated. after incubation, the contaminated roots were divided into three study groups: 35 roots irrigated with 2 ml of a 5% sodium hypochlorite (naocl) solution, 35 roots irrigated with 2 ml of a 5% naocl solution and further treated with cryo ... | 2013 | 23106670 |
| antibiotic susceptibility of periodontal enterococcus faecalis. | enterococcus faecalis may contribute to periodontal breakdown in heavily infected subgingival sites, particularly in patients responding poorly to mechanical forms of periodontal therapy. because only limited data are available on the antimicrobial sensitivity of enterococci of subgingival origin, this study evaluates the in vitro antibiotic susceptibility of e. faecalis isolated from periodontitis patients in the united states. | 2013 | 23106507 |
| characterization of the effects of an rpoc mutation that confers resistance to the fst peptide toxin-antitoxin system toxin. | overexpression of the fst toxin in enterococcus faecalis strain og1x leads to defects in chromosome segregation, cell division and, eventually, membrane integrity. the m7 mutant derivative of og1x is resistant to most of these effects but shows a slight growth defect in the absence of fst. full-genome sequencing revealed two differences between m7 and its og1x parent. first, og1x contains a frameshift mutation that inactivates the etar response regulator gene, while m7 is a wild-type revertant f ... | 2013 | 23104812 |
| bactericidal strontium-releasing injectable bone cements based on bioactive glasses. | strontium-releasing injectable bone cements may have the potential to prevent implant-related infections through the bactericidal action of strontium, while enhancing bone formation in patients suffering from osteoporosis. a melt-derived bioactive glass (bg) series (sio2–cao–caf2–mgo) with 0–50% of calcium substituted with strontium on a molar base were produced. by mixing glass powder, poly(acrylic acid) and water, cements were obtained which can be delivered by injection and set in situ, givin ... | 2013 | 23097502 |