Publications

the transfer of rat anemia to normal animals.	fifty-eight white and hooded rats have been splenectomized and all of them have shown a more or less severe anemia and an infection of the red blood cells with bartonella muris. another strain of white rats obtained from littlestown showed no anemia and no bartonellas in the blood after splenectomy, until exposed to infected rats. others of these littlestown rats, kept in the laboratory for some time before operation and exposed to infected rats, came down with bartonella anemia within 6 days af ...	1928	19869499
etiology of oroya fever : xiii. chemotherapy in experimental bartonella bacilliformis infection.	the therapeutic effect of several antiparasitic chemicals on experimental verruga peruana is described. the drugs were administered by intravenous injection according as the nodules (1) were already developed to an approximate maximum, or (2) were still in the active period of growth. the effect of the drugs was different under the two circumstances of their administration. when they were given after the maturity of the nodules they hastened the regressive process, but when given during active g ...	1928	19869508
the etiology of verruga peruana.	a saline suspension of a subcutaneous nodule excised from a verruga patient, and kept in the refrigerator for 14 days, on inoculation into two young macacus rhesus monkeys (nos. 33 and 34) induced irregular febrile reactions and enlargement of the lymph glands, and in one instance a subcutaneous nodule arose, independently of direct inoculation, on the tail. a microorganism has been isolated from the blood of both animals, and from the experimental nodule, which in pathogenic properties and in c ...	1927	19869238
etiology of oroya fever : vi. pathological changes observed in animals experimentally infected with bartonella bacilliformis. the distribution of the parasites in the tissues.	the pathological changes observed in the organs in macacus rhesus monkeys which have succumbed to severe infection with bartonella bacilliformis are similar to those found in human organs in persons dying of oroya fever. the characteristic changes in the liver are the zonal necrosis of the cells around the hepatic veins, involving active macrophagocytosis of invading polymorphonuclear leucocytes in the necrotic areas, and a marked endothelial hyperplasia in the sinusoids or around the portal vei ...	1927	19869264
etiology of oroya fever : vii. the response of the skin of macacus rhesus and anthropoid apes to inoculation with bartonella bacilliformis.	bartonella bacilliformis failed to induce lesions when merely rubbed on the surface of the intact skin of a chimpanzee, an ourang-utan, and numerous macacus rhesus monkeys, although when applied to the scarified skin of the same animals it gave rise to extensive lesions. application of infectious material to the scarified skin did not always induce verruga lesions, but intradermal inoculation almost invariably gave rise to nodule formation. the localization of bartonella bacilliformis in the ski ...	1927	19869265
etiology of oroya fever : viii. experiments on cross-immunity between oroya fever and verruga peruana.	nine monkeys (macacus rhesus) and a chimpanzee which had recently recovered from an infection with the oroya strain of bartonella bacilliformis were tested for immunity against the verruga strain of bartonella bacilliformis as well as against the homologous strain. complete immunity to both strains was demonstrated. the result establishes the identity of the strains and is in agreement with the result of comparative serological study. the criteria of recovery include not only the subsidence of f ...	1927	19869288
etiology of oroya fever : i. cultivation of bartonella bacilliformis.	a pure culture of a microorganism resembling in morphology and pathogenic action bartonella bacilliformis has been obtained from blood taken during life from a case of oroya fever which ended fatally. the blood taken at lima into citrate solution and transported to new york at refrigerator temperature yielded positive cultures 28 days after its withdrawal from the patient. the strain of bartonella bacilliformis thus isolated grows well on the semisolid leptospira medium, and also on slant agar c ...	1926	19869166
etiology of oroya fever : ii. viability of bartonella bacilliformis in cultures and in the preserved blood and an excised nodule of macacus rhesus.	1. animals immunized with the formalinized filtrates of young toxic cultures of b. botulinus produce an antitoxic serum poor in precipitins. 2. animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. animals immunized with toxin-free autolyzed bacteria produce a serum free from antitoxin but rich in specific precipitins. 4. animals immunized with the filtrates of an atoxic variant produce a serum free from ...	1926	19869204
etiology of oroya fever : iii. the behavior of bartonella bacilliformis in macacus rhesus.	the experiments reported here were carried on in the main with passage strains of bartonella bacilliformis, and the results indicate that the virulence of the organism has been considerably enhanced by passage through susceptible animals. while the animals of the earlier experimental series showed no anemia, some of the present group manifested a definite reduction in the number of red cells and in hemoglobin, and in one instance (m. rhesus 25) anemia was of the extreme type so often associated ...	1926	19869217
etiology of oroya fever : iv. the effect of inoculation of anthropoid apes with bartonella bacilliformis.	the inoculation of a chimpanzee with cultures and a passage strain of bartonella bacilliformis induced local reactions which, while definite and characteristic, progressed less rapidly and were much less striking than those in the control rhesus monkey. bartonella bacilliformis was demonstrated in the blood corpuscles with difficulty, and the fever was slight compared with the high and persistent fever of the rhesus monkey. in both the swelling of the lymph glands was an early symptom and consta ...	1926	19869218
etiology of oroya fever : v. the experimental transmission of bartonella bacilliformis by ticks (dermacentor andersoni).	experiments are reported in which bartonella bacilliformis was transmitted from infected to normal rhesus monkeys by the bite of the tick, dermacentor andersoni. a long period of feeding, both on the infected animal and on the normal animal subjected to infection, was required in order to secure positive results. the infection transmitted by the ticks was mild, but definite, as shown by the recovery of bartonella bacilliformis from the lymph nodes and blood.	1926	19869219