Publications

changes in blood chemistry in hypertensive patients during propranolol therapy.	propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (who i-ii) who were seen each week during 14-15 weeks. the initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. after that the patients were on an unchanged propranolol dose for 8 weeks (40, 80 or 160 mg four times daily). for all observed changes the correlation was studied to (1) dose, (2) free and total simultaneously determined plasma concentration and (3 ...	1984	6712860
effect of leucogenenol, a thymothyroid hormone, on the growth of immature and neonatally thymectomized rats.	the reports of early investigators that growth is delayed by thymectomy of immature animals have been confirmed. although growth is delayed by thymectomy, thymectomized animals approach asymptotically with age the same final weight as corresponding intact animals. treatment with leucogenenol, a thymothyroid hormone, accelerates the rate of growth of immature neonatally thymectomized rats to that of normal rats. however, treatment with leucogenenol does not increase the rate of growth of normal r ...	1984	6713283
elevated serum thyroglobulin as a manifestation of acute haemorrhage into the thyroid gland.	clinical observations and serial determinations of serum thyroglobulin (tg) were made in five patients with acute haemorrhage into the thyroid gland. fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum t4 and t3 were normal. although all patients showed an increase in serum tg, this was most obvious in three subjects and it gradually decreased as the nodule became smaller. there was no correlation between the serum tg concentration an ...	1984	6713690
gastric secretion and emptying in hypothyroidism.	hypothyroidism is commonly thought to cause decreased gastric emptying and secretion, but these may be related to associated autoimmune disease or chronic changes. therefore, we measured gastric emptying and secretion in 11 healthy controls and in nine patients (19-54 years old; five females and 4 males) rendered athyreotic by surgery and/or 131i for thyroid cancer. replacement t4 was stopped 47-65 days and subsequent replacement t3 was stopped 33-40 days before the study. all patients were symp ...	1984	6714056
iodothyronine deiodination reaction types in several rat tissues: effects of age, thyroid status, and glucocorticoid treatment.	two types of iodothyronine 5'-deiodination have been characterized previously in rat tissues. they can be distinguished by inhibition of type i but not type ii by 6-n-propylthiouracil, by the relative suitability of t4 and rt3 as substrates, rt3 much better than t4 for type i and t4 as good as, or better than, rt3 for type ii, and by the concentration of t4 required to inhibit deiodination of rt3, 1-10 microm for type i and 1-10 nm for type ii. type i activity (6-n-propylthiouracil sensitive) is ...	1984	6714153
effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl.	accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by t. f. davison, j. g. rowell, and j. rea, [1981) j. endocrinol. 89, 371-378). radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg ki/liter) or injections of thyroxine (t4: 5 x 50 micrograms t4/kg body wt), in agreement with published findings. treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125i up ...	1984	6714654
erythropoietin, testosterone, and thyroxine in the erythropoietic response of the snake, xenochrophis piscator.	the erythropoietic response of snakes was examined after injecting human urinary erythropoietin (ep), testosterone propionate (tp), and l-thyroxine (t4), separately and in combinations, into starved ophids. the effect of starvation was reflected by a decrease in the number of erythrocytes, a fall in hemoglobin concentration, and a decline in hematocrit. statistically significant elevation of erythrocyte number, hemoglobin concentration, and hematocrit was observed at 24 hr following the administ ...	1984	6714657
low triiodothyronine and raised reverse triiodothyronine levels in patients over fifty years of age who have type ii diabetes mellitus: influence of metabolic control, not age.	several studies have demonstrated that the uncontrolled diabetic state in both type i as well as type ii diabetes mellitus is characterized by altered thyroid hormone metabolism, which results in the lowering of serum triiodothyronine (t3) levels and a reciprocal elevation of t3 (rt3) levels. because the majority of type ii diabetics are over 50 years of age and because numerous previous reports have implicated aging as a cause of low t3 and high rt3 levels, we studied 220 type ii diabetics from ...	1984	6715765
diminished lymphocytic cortisol metabolism-enhancing effect in endogenous thyrotoxicosis.	a study was carried out to determine the effect on lymphocytic cortisol metabolism (lcm) of plasma from 62 patients with diffuse thyrotoxic goitre (dtg), 14 patients with toxic nodular goitre (tng) and ten hypothyroid patients. plasma of 33 healthy donors served as controls. a known concentration of human lymphocytes was incubated with cortisol in media containing 50% phosphate-buffered saline (pbs) and 50% of one of the following additions: (1) pbs, (2) homologous plasma (hp), (3) heterologous ...	1984	6716032
the effect of propranolol and other antihypertensive drugs on preganglionic sympathetic activity in the cat.	preganglionic sympathetic nerve activity was recorded from the white rami of t3/t4 along with blood pressure, heart rate and femoral arterial conductance in vagotomised, atropinised cats under alpha-chloralose/pentobarbitone anaesthesia, and paralysed by gallamine. injection of propranolol or trimetaphan caused falls in mean blood pressure and concomitant rises in preganglionic sympathetic nerve activity. propranolol was then infused over 3 hr with a stepwise increase in dose rate. this infusion ...	1984	6717753
[purification and characteristics of an rna-ligase preparation from bacteriophage t4].	a purification techniques was developed to obtain a preparation of the bacteriophage t4 rna-ligase (ec 6.5.1.3) free of contaminating nuclease activities. it includes fractioning on phosphocellulose and deae-cellulose, chromatography on deae-cellulose, isoelectric sedimentation, gel filtration through sephadex g-100 and chromatography on hydroxylapatite and aminohexyl-sepharose. the enzyme yield amounts to 30-37%. by means of biochemical tests, the preparation of rna-ligase was found to be good ...	1984	6718329
high efficiency of energy utilization in 'cafeteria'-and force-fed rats kept at 29 degrees.	male, sprague-dawley (charles-river) rats, of initial weight 272 g, were given a powdered stock diet (t1) ad lib., force-fed a synthetic diet (t2) or offered a range of palatable foods in conjunction with the powdered stock diet (t3) or a similar diet supplemented with certain minerals and vitamins (t4). metabolizable energy (me) intake (kj/d) averaged 303, 453, 402 and 383 for t1, t2, t3 and t4 respectively and corresponding weight gains were 5.5, 6.9, 8.2 and 7.9 g/d and were significantly dif ...	1984	6722082
[calorimetric study of bacteriophage t4 ghosts].	heat-induced structural transitions of bacteriophage t4 ghosts have been studied using differential scanning microcalorimetry and electron microscopy. the tail reorganization process is not an exothermic one. it is shown to correlate well with a heat absorption peak at maximum of 70 degrees c, but the sheath contraction and the hexagon -to-star base-plate transition themselves appear to proceed without any significant changes in enthalpy.	1984	6722190
lung function of children treated for malignant extrapulmonary tumors.	lung function was studied in 29 children suffering from extrapulmonary tumors of varying etiology (wilm's tumor, n = 7; bone malignancy, n = 17; nasopharyngeal epithelioma, n = 5). lung volume: vital capacity (vc) and functional residual capacity (frc), lung mechanics: lung resistance (rl), dynamic lung compliance (cldyn) and static lung compliance (clstat) and lung transfer factor for co (tlco), and blood gases were determined at different stages of therapy: at t0, before any aggressive treatme ...	1984	6722361
polyamines in breast cancer.	polyamine levels (putrescine, spermidine and spermine) in breast cancers (n = 54) were measured as a potential guide to prognosis. values (expressed as nmol per 100 mg tumour) ranged from: 0.9 to 4.5 for putrescine, 4.2 to 29.8 for spermidine and 5.6 to 39.7 for spermine concentration. increased intracellular polyamine levels were positively correlated with factors known adversely to affect survival after mastectomy, namely histological grade iii and oestrogen-receptor negative status. advanced ...	1984	6722462
effect of propylthiouracil on the thyroid tumorigenesis induced by n-bis(2-hydroxypropyl)nitrosamine in rats.	the effect of 0.15% propylthiouracil (ptu) on thyroid tumorigenesis was studied in male wistar rats given a single i.p. injection of 280 mg of n-bis(-2-hydroxypropyl)nitrosamine (dhpn) per 100 g body weight. the mean weights of the thyroid of rats treated with dhpn followed by ptu and with ptu alone were significantly higher than those of rats treated with dhpn only and control rats. the incidences of follicular adenoma at the end of week 20 of the experiment were 100% (21/21) in rats treated wi ...	1984	6722982
free thyroxin index and direct measurements of free thyroxin compared for evaluating postpartum autoimmune thyroid dysfunction.	measurement of free thyroxin (ft4) by a recently introduced commercial assay (amerlex free t4 ria) was compared with the calculated free thyroxin index (ft4i) for serum from 104 postpartum women. of these, 63 had transient thyroid dysfunction due to autoimmune thyroiditis, six had transient graves' thyrotoxicosis, and 35 were euthyroid with no signs of autoimmune thyroid disease. the correlation between results for ft4 and the calculated fti for 95 serum samples from women with no signs of autoi ...	1984	6723049
endemic infantile hypothyroidism in a severe endemic goitre area of central africa.	thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of ubangi, northern zaire. serum t4 was at the lower limit of normal at birth (104 +/- 4 nmol/l) and stayed at that level during the first year of life (123 +/- 9) (ns), but decreased to 75 +/- 8 (p less than 0.001) at 2-4 years and to 62 +/- 6 (p less than 0.001) at 5-7 ...	1984	6723080
successful treatment of thyrotoxic crisis with plasma exchange.	a 36-yr-old woman with thyroid storm was successfully treated with plasma exchange. after the first plasma exchange, free serum thyroxine (t4) was decreased and serum thyroxine-binding globulin (tbg) was significantly increased. the decrease in the patient's free t4 level after plasma exchange can perhaps be attributed to t4's increased binding capacity. plasma exchange may be an effective therapy for thyrotoxic crisis and should be performed immediately if conventional therapy fails to improve ...	1984	6723341
[evaluation of multi-disciplinary treatment combined with intra-arterial chemotherapy for carcinoma of the meso-pharynx].	forty-seven cases of carcinoma of the mesopharynx , treated from 1973 to 1981 at gunma cancer center, were evaluated. the following results were obtained, according to histopathologic diagnosis, 37 were well-differentiated squamous cell carcinoma and other cases were poorly differentiated squamous cell carcinoma. classification of the site of the disease showed the most frequent site was lateral wall type (31 cases, 65.9 per cent) followed by anterior wall (9 cases), superior wall (5 cases), and ...	1984	6732248
behaviour of serum t3, rt3, tt4, ft4 and tsh levels after exercise on a bicycle ergometer in healthy euthyroid male young subjects.	in order to know thyroid function during physical activity, just studied by several authors without univocal findings, we have submitted 10 young subjects, non athletes, aged 22-25 years (mean age 23, 6 +/- 1, 43) to a biologically maximal exercise on a bicycle ergometer. we have also examined the change of tsh serum levels during exercise. our data show an evident increase of t4 (18, 60% at 10'), p less than 0.025, an increment of ft4 (28, 49 soon after the strain), and no relevant change of t3 ...	1984	6732949
solubilization of peroxidase from porcine thyroids and characterization by photoaffinity labelling.	peroxidase was solubilized without proteolysis from porcine thyroid particulate fraction with the nonionic detergent, 1-o-n-octyl-beta-d-glucopyranoside. the enzyme was able to catalyze the oxidation of guaiacol and the iodination of bovine serum albumin (33 atoms of iodine per molecule protein). binding studies performed with the partially purified enzyme indicated that the substrates thyroxine (t4) and tyrosine compete for the same binding site on the enzyme. dissociation constants of 0.9 nm a ...	1984	6733117
does amiodarone affect heart rate by inhibiting the intracellular generation of triiodothyronine from thyroxine?	the hypothesis that the antiarrhythmic drug amiodarone slows down the heart rate by its inhibitory action on the intracellular conversion of thyroxine (t4) to 3,5,3' triiodothyronine (t3) was investigated. for this purpose we compared the effect of amiodarone with that of another potent inhibitor of the t4----t3 conversion, i.e. the radiographic contrast medium iopanoic acid, on the heart rate of unanaesthetized guinea-pigs. both amiodarone and, to an even greater extent, iopanoic acid induced a ...	1984	6733357
induction of spinal seizures by natural stimulation in cats.	transection of the spinal cord of the cat at a thoracic or lumbar level results, after as short a period as 12 days, in a preparation with such altered excitability that repeated natural stimulation of the dermatome just caudal to the transection site will induce, in as short a time as 3 days, seizure discharges. the trigger zone for the seizure spreads to caudal dermatomes when these caudal regions are repeatedly stimulated. the 'typical' t4-t7 seizure is a scratch reflex followed by the tonic- ...	1984	6733453
the mononuclear cells of human mesenteric blood, intestinal mucosa and mesenteric lymph nodes: compartmentalization of nk cells.	the proportions of t cell subsets and leu 7+ cells and the spontaneous cell-mediated cytotoxicity (scmc) of isolated mononuclear cells have been determined across the mesenteric vascular bed and along the intestinal mucosal-mesenteric lymph node (mln) axis in patients undergoing abdominal surgery. whereas the proportion of t4+ and t8+ cells were similar in simultaneously taken pvb and mesenteric venous blood (mvb), the proportion of leu 7+ cells was higher in mvb in 16 of 17 studies (15.4 +/- 6. ...	1984	6733977
a study of cardiac effects of thyroid hormones: evidence for amelioration of the effects of thyroxine by sodium ipodate.	we studied the effects of daily ip administration of t4 (200 micrograms/100 g bw) or t3 (50 micrograms/100 g) to the rat (six per group) for 3 days with or without sodium ipodate (6 mg/100 g), propylthiouracil (ptu; 2 mg/100 g), propranolol (0.5 mg/100 g), or amiodarone (2.5 mg/100 g) on cardiac weight, 3',5'-diiodothyronine (3',5'-t2) to 3'-monoiodothyronine monodeiodinating activity (ma), mitochondrial alpha-glycerophosphate dehydrogenase (alpha gpd), and/or cytosolic ornithine decarboxylase ( ...	1984	6723573
the contribution of local thyroxine monodeiodination to intracellular 3,5, 3'-triiodothyronine in several tissues of hyperthyroid rats at isotopic equilibrium.	the local conversion of t4 as a source of intracellular t3 in several organs of both hypothyroid and euthyroid rats has recently been recognized to be an important phenomenon. in the present study the source and quantity of t3 in various peripheral tissues of hyperthyroid rats were investigated. athyreotic rats received a continuous iv infusion of 3.5 micrograms t4/100 g bw x day over a prolonged period in order to attain hyperthyroid conditions. at the same time, the animals also received a con ...	1984	6734513
development-associated changes in thyroxine kinetics in juvenile salmon.	smoltification is a transformation that occurs in some species of salmon, during which solitary fish in fresh water become schooling fish and migrate to the sea. this process is accompanied by large increases in plasma t4. t4 secretion rate and other parameters of t4 metabolism in juvenile coho salmon were estimated by applying kinetic analyses to measurements of the disappearance of injected t4 radiotracer from plasma. studies were performed at the beginning (march) and end (may) of the increas ...	1984	6734520
hepatic dysfunction in primary hypothyroidism.	twenty-seven patients with primary hypothyroidism were studied to evaluate the relationship between hepatic function and thyroid hormone deficiency in this disorder. in hypothyroidism, hypergammaglobulinemia was found in 71%, elevated glutamic oxaloacetic transaminase (got) in 48%, high lactic dehydrogenase (ldh) in 58%, hypercholesteremia in 52% and low elimination rate constant of indocyanin green (kicg) in 44%. in each criterion of liver function, these patients were divided into two groups, ...	1984	6734526
genetic evidence for physical interactions between enzymes of nucleotide synthesis and proteins involved in dna replication in bacteriophage t4.	we have found that mutations in phage t4 genes 41 (five of five) and 61 (three of three) cause resistance to the folate analogue pyrimethamine that inhibits t4 dihydrofolate (fh2) reductase. these genes code for subunits of a t4 primase and are part of a putative t4 replication complex. in contrast to many previously isolated folate analogue-resistant (far) t4 mutants, these t4 primase mutants do not overproduce fh2 reductase nor do they alter its primary structure. a new mutant with a single le ...	1984	6735173
variations in circulating thyroxine and triiodothyronine concentration in relation to spring migration in rosy pastor, sturnus roseus.	in rosy pastor, sturnus roseus, the spring premigratory fattening observed during april was preceded by a significant increase in circulating thyroxine (t4) and triiodothyronine (t3) concentrations. plasma t4 and t3 both declined significantly by may when in nature the migrating conspecifics had departed for their breeding ground. a possible role of thyroid hormones in the migratory disposition of this bird is, therefore, suggested.	1984	6735365
central tarsal bone fractures in the racing greyhound: a review of 114 cases.	a total of 114 central tarsal bone (tc) fractures, including associated secondary fractures, were identified in 114 racing greyhounds. the fractures were classified according to a previously described scheme. the type iv tc fracture, dorsal and medial slab fractures, was most common. a tc fracture alone, or a tc fracture with associated fractures of the 4th tarsal bone (t4), calcaneus, or t4 and lateral base of the 5th metatarsal bone were the most commonly observed. the prevalence of secondary ...	1984	6735872
type ii iodothyronine 5'-deiodination by human and rat placenta in vitro.	t4 and rt3 5'-deiodination were measured in human and rat placental homogenates. rt3 5'-deiodination rates were reduced 5-40% by 1 mm 6-n-propylthiouracil (ptu), but t4 5'-deiodination was not affected by 1 mm ptu. in human tissue, homogenates of the chorionic membrane decidua had greater ptu-insensitive activity than homogenates of trophoblastic tissue or amnion. in the rat placenta, basal zone homogenates had greater activity than homogenates of placental labyrinth or amnion. the distribution ...	1984	6736203
influence of hyper- and hypothyroidism on subcutaneous adipose tissue blood flow in man.	subcutaneous adipose tissue (at) blood flow (bf) in the abdomen, thigh, and arm was determined by measuring the local clearance of [133]xe in patients with untreated hyper- or hypothyroidism (n = 10, n = 7); six patients in each group were reexamined after treatment when they were euthyroid. abdominal atbf before treatment was 5.5 +/- 0.8 (se) ml/min x 100 g at in the hyperthyroid patients and 1.3 +/- 0.3 ml/min x 100 g at in those who were hypothyroid. after therapy abdominal atbf was 60% lower ...	1984	6736204
environmental salinity and the thyroidal response to thyrotropin in juvenile coho salmon (oncorhynchus kisutch).	the effect of environmental salinity on the thyroidal response, measured by plasma concentrations of thyroxine (t4), to exogenous bovine thyrotropin (btsh) was assessed early and late in the smoltification of coho salmon (oncorhynchus kisutch). a single injection of 100 miu btsh significantly increased plasma t4 concentrations in fish in both fresh water and seawater, and both early (march 19) and late (may 24) in smoltification. in fish transferred to seawater, the increase in t4 titers was som ...	1984	6736902
oral triiodothyronine administration lowers plasma fibronectin levels in humans.	it has been shown that both serum triiodothyronine (t3) and plasma fibronectin values decline with fasting and increase with treatment of diabetic ketoacidosis in a paralles manner. to evaluate the mechanism responsible for these changes, we examined the effects of both oral t3 administration and fasting in six healthy, adult subjects. initial plasma fibronectin values were normal in four subjects (group 1) and decreased in two subjects (group 2). initial serum t3 and thyroxine (t4) values were ...	1984	6738361
thyromimetic effects of 3,5-dimethyl,3'-isopropyl thyronine (dimit) and 3,5-diethyl,3'-isopropyl thyronine (diet) in various tissues of the rat.	we have examined the effects of treatment of the rat with 3,5-dimethyl-3'-isopropyl thyronine (dimit) and 3,5-diethyl-3'-isopropyl thyronine (diet) on serum thyrotropin (tsh) concentration, heart weight, hepatic outer ring (5'-) monodeiodination of t4 to t3, cardiac outer ring monodeiodination of 3'-5'-diiodothyronine (3',5'-t2) to 3'-monoiodothyronine (3'-t1), and cerebral cortical monodeiodination of 3,5-t2 in the inner ring to 3-t1. groups of four to seven rats were injected intraperitoneally ...	1984	6738362
ethanol feeding and thyroid hormone monodeiodination.	adult male rats were placed on a 3 week regimen of ethanol (as 20% of total calories) in a nutritionally adequate diet, and controls were matched equicalorically without ethanol. serum measurements of t4, t3, ft4, rt3, and tsh were performed in both the fed and the fasted state (18 hours). in the fed state, serum hormone measurements did not differ between control and ethanol-treated rats. overnight fasting had a significant effect in decreasing serum t3 level in both experimental and control ra ...	1984	6738368
oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome.	we studied the frequency with which unexplained oral candidiasis led to unequivocal acquired immunodeficiency syndrome (aids) in patients at risk. twenty-two previously healthy adults with unexplained oral candidiasis, of whom the 19 tested had a reversed t4/t8 ratio and 20 had generalized lymphadenopathy, were compared with 20 similar patients with a reversed t4/t8 ratio and generalized lymphadenopathy who did not have oral candidiasis. all were intravenous-drug abusers, homosexual or bisexual ...	1984	6738653
thyroid hormone metabolism and the source of plasma triiodothyronine in 2-week-old rats: effects of thyroid status.	earlier studies have shown larger increments in serum t3 in 2-week-old congenitally hypothyroid rats than in euthyroid controls after injections of small doses of t4. since hepatic and renal 5'-deiodination of t4 to t3 in vitro (5' d-i) is reduced during the neonatal period and in hypothyroidism, those results suggest that there may be major changes in the distribution and metabolism of t3 or that an alternative enzymatic pathway is the predominant source of extrathyroidally produced t3 in these ...	1984	6723586
localization of the cells of origin for primary afferent fibers supplying the gallbladder of the cat.	horseradish peroxidase was utilized to study the distribution of afferent fibers from the gallbladder in cats. the afferent cell bodies were found in the nodose ganglion and t4 to l1 dorsal root ganglia.	1984	6723891
[diagnosis and therapy of patients with simple goiter within the scope of a thyroid gland ambulatory care service].	serum thyroxin, triiodothyronine, and basal and trh-stimulated tsh concentrations, were determined in 285 patients with simple goitre. in addition, the efficiency of two years' therapy with a t4/t3 preparation (ratio 4:1) was investigated. patients with goitres of larger size (stage ii und iii) presented with lower serum t4 and higher serum t3 concentrations than patients with smaller goitres (stage i) and controls. a decreased or elevated tsh response to trh stimulation was more frequently foun ...	1984	6740282
[free thyroxine estimation for screening of hyper- and hypothyroidism in an adult population].	serum free thyroxine (ft4) was determined in 1,114 adults (male 239, female 875) in a periodic health evaluation in 1980 to detect unsuspected thyroid dysfunction, especially hyper- and hypothyroidism. the participants were dwelling in two towns of miyagi prefecture. beside ft4, serum t4 and t3 were also determined by radioimmunoassay. if thyroid dysfunction was suspected, further detailed examinations such as trh-test (500 micrograms i.v.), radioimmunologic determinations of serum tsh and tbg, ...	1984	6724056
thyroid function and prolactin levels in insulin-dependent diabetic children and adolescents.	we evaluated serum thyroid hormones, tsh, and prolactin before and after induction of trh and thyroid microsomal autoantibodies in 91 diabetic children and adolescents (mean age 11.11 +/- 4.13 yr), with illness ranging from a few days to 14.25 yr, and in 127 "short-normal" subjects (mean age 10.32 +/- 3.18 yr). all were clinically euthyroid. the control pubertal subjects showed t4, rt3, tbg, and rt3/t3 ratio values that were significantly lower than those of prepubertal subjects. the prl area wa ...	1984	6724148
[staging of metastasized bladder cancer using parietocystotomography].	to date no diagnostic procedure has been able accurately to stage carcinomas of the urinary bladder. parietocystotomography by means of instillation of air and nitrous oxide was used in an attempt to distinguish between the tumour infiltration stages t3a , t3b and t4 and to depict them radiologically. using this method it is possible to achieve a high degree of concurrence between radiological findings and the pathological-anatomical substrate. the methods, results achieved and the limits of the ...	1984	6741300
studies on the conversion of thyroxine to 3,5,3'-triiodothyronine in normal and thyroidectomized chickens.	the possibility of conversion of l-thyroxine (t4) to l-3,5,3'-triiodothyronine (t3) and to 3,3',5'-triiodothyronine (reverse-t3, r-t3) has been investigated in chickens. reverse-t3 could not be detected in normal animals. both thyroidectomized and normal animals were able to convert exogenous t4 to t3. the administration of propylthiouracyl blocked this conversion to a greater extent than had been expected from the data on mammals. the conversion ratio is higher than in any other species reporte ...	1984	6724289
the effects of pituitary, thyroid, pancreatic and sexual hormones on body length and weight and organ weights of snell dwarf mice.	a dose-dependent increase in body length and weight can be induced in snell dwarf mice by human, porcine and bovine growth hormones, ovine prolactin, bovine tsh, t4 and t3, and to a lesser extent by insulin. in contrast, porcine fsh, equine lh, testosterone, oestradiol and glucagon influenced neither body length nor weight. beside body length and weight, the weight of many organs is stimulated by hormonal treatment. gh, t4 and t3 have a rather similar spectrum of effects, with exceptions for the ...	1984	6724329
effect of the dw gene on growth, plasma hormone concentrations and hepatic enzyme activity in a randombred population of chickens.	the effect of the dw gene on growth, lipid deposition, plasma hormone concentration, and enzyme activity in a randombred population of chickens was studied. the reciprocal crosses were examined as well as purebred dwarf and normal populations. body weight, carcass fat, plasma growth hormone (gh), triiodothyronine (t3), thyroxine (t4), hepatic malic enzyme (me) and citrate cleavage enzyme (cce) activities were determined at 0, 2, 4 and 6 weeks. body weights of dwarf birds were less than normal bi ...	1984	6724333
antihormonal effects of plant extracts: iodothyronine deiodinase of rat liver is inhibited by extracts and secondary metabolites of plants.	aqueous extracts from plants such as lycopus virginicus , melissa officinalis ( laminaceae ), and lithospermum officinale ( boraginaceae ), containing various antihormonal components, also inhibit both the extrathyroidal enzymic t4-5'-deiodination to t3 and the t4-5'-deiodination. the effects were dose dependent and ultimately complete using rat liver microsomes as a source of the enzyme in vitro. the "specific inhibitory activity" of extracts depends on the plant species used and the extraction ...	1984	6724503
serum potassium and aldosterone levels in gossypol-treated rats.	male rats fed with 30 mg/kg gossypol for 2 or 4 weeks exhibited a decrease in growth but showed no change from control in serum potassium levels. serum aldosterone levels remained unchanged, but serum testosterone levels were significantly reduced after 4 weeks of treatment. serum t3 was significantly increased after 2 or 4 weeks of treatment, while serum t4 was not different from control. it is concluded that gossypol at a dose that is sufficient to produce sterility in rats did not change seru ...	1984	6724725
direct assay of free thyroxine in the newborn.	several reagent sets are available, which allow a direct assay without dialysis of the free, bioavailable part of total thyroxine in plasma. a methodological investigation showed that the solid phase (coated tubes) kit from clinical assay gives reproducible results in plasma volumes of 50 microliter. plasma samples from 95 newborns have been assayed at the 4th to 5th day of life. the mean concentration for free thyroxine of 62 infants born at term was 17 pmol/l with a log 2 sd range of 10-28 pmo ...	1984	6724997
predicting the response of head and neck cancers to radiation therapy with a multivariate modelling system: an analysis of the rtog head and neck registry.	two thousand and sixty-six patients with primary head and neck cancers were entered in the rtog head and neck cancer registry between 1977 and 1980. nine hundred and ninety-seven (997) evaluable patients were treated initially with radiation therapy alone. tumor site, t-stage, n-stage, histology, degree of infiltration, degree of differentiation, patient age, sex and karnofsky performance score were all prospectively recorded. t-stage (p less than .001), n-stage (p = .007), primary site (p less ...	1984	6725038
antithyroid treatment of maternal hyperthyroidism during lactation.	eleven pregnant women were treated for hyperthyroidism with carbimazole (cz) and one with propylthiouracil (ptu). based upon a previous study it was decided that lactation should be permitted if the dose required after delivery did not exceed 15 mg of cz or 150 mg of ptu. in the patients studied here the daily dose of cz varied from 5 to 15 mg and that of ptu was 125 mg. tsh was measured in cord blood and in the blood of the newborn infants usually after 2 and 3 weeks of lactation. serum t4 was ...	1984	6744638
comparison of plasma and urinary methods for the direct measurement of the thyroxine to 3,5,3' - triiodothyronine conversion rate in man.	a further development of a new method recently proposed for the direct measurement of the conversion ratio (cr) of t4 to t3 in man is presented. [125i]t4 and [131i]t3 are injected simultaneously, and sephadex chromatography is performed on urine samples to determine [125i]t3 formed in vivo, while plasma samples are used to measure the injected tracers. cr is calculated with the assumption that urinary [125i]t3 closely reflects [125i]t3 appearing in plasma after the injection of precursor [125i]t ...	1984	6725516
l-thyroxine absorption in patients with short bowel.	because the exact site of thyroid hormone absorption in man is not known, we assessed the absorption of oral [125i]na-l-t4 in patients with varying lengths of intact bowel and correlated this absorption with bowel length. two normal subjects and five patients with surgical bowel resections, all of whom were euthyroid, were studied. each received a tracer dose of [125i]na-l-t4 orally, and serial samples of serum were assayed for radioactivity both with and without butanol extraction. the peak ser ...	1984	6725518
high concentrations of furosemide inhibit serum binding of thyroxine.	serum samples taken from four patients who had low serum t4 concentrations (less than 2 micrograms/dl) during severe non-thyroidal illness were found to contain a heat-stable, dialyzable inhibitor of 125i t4 binding to plasma proteins. inhibitory activity coincided with high dose furosemide treatment for oliguric renal failure. inhibition was proportional to the serum furosemide concentration and the effect was reproduced in vitro by addition of furosemide to normal serum. the inhibitory effect ...	1984	6725526
transient impairment of thyroid function in newborn from an area of endemic goiter.	thyroid function was studied in newborn from 3 areas of sicily in which iodine intake is normal (area a), moderately decreased (area b), and severely decreased (area c). in the latter 2 areas, there is a high incidence of goiter and in area c endemic cretinism is present. tsh and t4 were measured in the cord serum of 5673 newborn from area a, 2096 from area b, and 184 from area c. the mean tsh value was significantly higher in areas c (p less than 0.001) and b (p less than 0.005) when compared t ...	1984	6725528
effects of hysterectomy and in-vivo treatment with uterine extracts on plasma concentrations of growth hormone, thyrotrophin and thyroid hormones in rats: a kinetic study.	plasma concentrations of gh, tsh, tri-iodothyronine (t3) and thyroxine (t4) were measured in adult rats 2 and 4 weeks after ovariectomy and and ovariohysterectomy. two weeks after ovariohysterectomy, the concentration of gh was significantly higher, but tsh and t3 concentrations were significantly lower than in rats which had been ovariectomized only. hysterectomy had no effect on plasma gh and tsh concentrations if it was performed 2 weeks after ovariectomy. plasma t3 had decreased by 2 weeks a ...	1984	6726104
recovery of body weight from below "set point" in mature female rats.	in this study we determined the time course of changes in body composition and of serum concentrations of some hormones in mature rats returning to "set point" following weight loss. groups of six female rats were fed ad libitum for 10 days. carcass composition of one group was determined. a control group continued to eat ad libitum. the others were restricted to 5 g per rat per day for 22 days. carcass composition of groups of rats was determined after 0, 2, 6, 13 and 20 days of refeeding. of 6 ...	1984	6726478
the influence of partial food deprivation on the quantity and source of triiodothyronine in several tissues of athyreotic thyroxine-maintained rats.	in the present study the influence of partial food deprivation (pfd) on the quantity and source of t3 [i.e. t3 derived from local t4 to t3 conversion (lc t3 (t4] vs. plasma-derived t3] in several rat tissues was investigated. two groups of athyroid rats on a synthetic diet received a continuous iv infusion consisting of t4 (1.0 microgram/100 g bw x day), [125i]t4, and [131i]t3 over a prolonged period. for one group of rats the daily food intake was restricted by one third to maintain constant bw ...	1984	6745175
substantial induction of a new serum protein by growth hormone: physiochemical and physiological characterization.	serum from gh-treated hypophysectomized rats was examined by two-dimensional gel electrophoresis followed by silver staining to screen a large number of serum proteins for gh responsiveness. a distinctive, highly acidic protein of 60,000 mol wt was clearly responsive to gh administration, increasing 7-fold over levels observed in hypophysectomized controls. administration of t4, corticosterone, and 5 alpha-dihydrotestosterone failed to induce this protein; however, addition of gh to this regimen ...	1984	6745189
metabolism of 3,3'-diiodothyronine in rat hepatocytes: interaction of sulfation with deiodination.	production of 3,3'-diiodothyronine (3,3'-t2) is an important step in the peripheral metabolism of thyroid hormone in man. the rapid clearance of 3,3'-t2 is accomplished to a large extent in the liver. we have studied in detail the mechanisms of this process using monolayers of freshly isolated rat hepatocytes. after incubation with 3,[3'-125i]t2, chromatographic analysis of the medium revealed two major metabolic routes: outer ring deiodination and sulfation. we recently demonstrated that sulfat ...	1984	6745193
phenolic and tyrosyl ring deiodination in thyroxine from rat retina during postnatal development.	to elucidate tetraiodothyronine (t4) metabolism in developing rat retina 5-monodeiodinating and 5'-monodeiodinating activities were studied. t4 was incubated with aliquots of homogenate or crude primary subcellular fractions, and the 3,3',5'-triiodothyronine (rt3) or 3,5,3'-triiodothyronine (t3) produced were measured by radioimmunoassay. reaction rates were dependent on incubation time, tissue amount, temperature and ph. the optimum ph values were 7.8 and 7.2 respectively for rt3-forming and t3 ...	1984	6745264
familial dysalbuminemic hyperthyroxinemia (fdh): inadequacy of the "analog" methods for assaying free-t4 levels.	free-t4 levels were determined in familial dysalbuminemic hyperthyroxinemia (fdh) subjects. in agreement with their euthyroid status free-t4 levels were within the normal range when tested by equilibrium dialysis and by the ft4 immophase method (corning medical). however, when using the recently introduced "analog" methods, either amerlex ft4 or becton-dickinson ft4, free-t4 values were markedly higher than the control values. this discrepancy is probably due to artifactual binding of the labele ...	1984	6745298
[parenteral replacement of thyroid hormones].	because of the development in parenteral nutrition, the replacement of thyroid hormones in hypothyroid or athyroid patients under intravenous hyperalimentation has become a new problem to be considered. we tried parenteral replacement of the hormones, intravenously or by enema, in three such patients. two patients, 54 y-o and 64 y-o females, who underwent laryngo-esophago-thyroidectomy for cervical esophageal cancer or thyroid cancer, had replacement with intravenous l-thyroxine with an initial ...	1984	6745469
[a case of iodide myxedema observed for 3 years under a low iodide diet--especially on the restoration of the mechanism of escape from the wolff-chaikoff effect].	a 47-year-old housewife was admitted to our hospital because of general fatigue and constipation suggesting hypothyroidism. for 3 years before admission, general fatigue, arrhythmia, dry skin, drowsiness, cold intolerance and hypermenorrhea occurred insidiously. she had habitually taken considerable amounts of seaweed every day, e.g. more than 50 g of " kombu " for more than 5 years and at least 1 g of " wakame " for 6 months. on admission, serum thyroxine (t4) was 1.3 micrograms/dl, serum triio ...	1984	6745470
thyroid and annual gonad development, body weight, plumage pigmentation, and bill color cycles of lal munia, estrilda amandava.	long-term administration of l-thyroxine (t4) in the wax bill (lal munia) inhibited the current gonad development cycle, and the increase in gonadal volume in the second cycle was suppressed only by higher concentrations. gonadal inhibition by high but not by low doses of l-t4 was associated with a failure in the development of lh-dependent pigmented nuptial plumage. this suggests that l-t4 depresses fsh secretion more readily than lh secretion. the results indicate that the effects of l-t4 admin ...	1984	6745630
thyroid and adrenal responses of ducks (anas platyrhynchos) during saline adaptation.	fresh water-reared aylesbury ducklings were given 0.1 or 0.2 m nacl drinking water and variations in the plasma concentrations of thyroxine (t4), triiodothyronine (t3), corticosterone, and aldosterone were determined. within 24 hr of being transferred to 0.2 m nacl the corticosterone concentration was increased, whereas the levels of plasma t3 and aldosterone were reduced. the increase in corticosterone secretion persisted for at least 7 days, but the t3 and aldosterone concentrations had return ...	1984	6745632
isolation and characterization of conditional alleles of bacteriophage t4 genes uvsx and uvsy.	the bacteriophage t4 uvsw, uvsx and uvsy gene functions are required for wild-type levels of recombination and for normal survival and mutagenesis after treatments with ultraviolet (uv) and ionizing radiations. the ability of uvsx and uvsy mutations to suppress the lethality of gene 49 mutations was used to select temperature-sensitive and amber alleles of these two genes. (uvsw mutations do not suppress gene 49 mutations.) a simple and powerful complementation test was developed to assist in as ...	1984	6745639
thermal rescue of uv-irradiated bacteriophage t4 and biphasic mode of action of the wxy system.	when ultraviolet-irradiated bacteriophage t4 is assayed at plating temperatures ranging from 20 degrees to 40 degrees, its survival increases at the higher temperatures. this "thermal rescue" requires an intact wxy system but not the denv pyrimidine dimer excision system. mutation rates decrease with increasing temperature, indicating that some lesions processed in a mutagenic manner at lower temperatures are accurately repaired or circumvented at high temperatures. when both the cold sensitivit ...	1984	6745640
expression of a dna replication gene cluster in bacteriophage t4: genetic linkage and the control of gene product interactions.	the results of this study bear on the relationship between genetic linkage and control of interactions between the protein products of different cistrons. in t4 bacteriophage, genes 45 and 44 encode essential components of the phage dna replication multiprotein complex. t4 gene 45 maps directly upstream of gene 44 relative to the overall direction of reading of this region of the phage chromosome, but it is not known whether these two genes are cotranscribed. it has been shown that a nonsense le ...	1984	6745641
serum thyroxine and triiodothyronine concentrations in canine pyoderma.	in an effort to evaluate the effect of pyoderma on circulating iodothyronines, plasma triiodothyronine (t3) and thyroxine (t4) values were determined before and after thyroid stimulating hormone administration in 25 dogs with pyoderma and in 15 controls. basal t4 values were increased in dogs with pyoderma, but neither stimulated t4 nor t3 values were altered by this condition. on the basis of low values for circulating iodothyronines, hypothyroidism was suspected in 3 dogs in the pyoderma group ...	1984	6746394
thyroxine distribution and metabolism in familial dysalbuminemic hyperthyroxinemia.	we studied two families with familial dysalbuminemic hyperthyroxinemia (fdh), a recently described entity characterized by marked elevation of serum t4 due to increased binding of t4 to albumin. the seven affected subjects had elevated serum total t4 levels (range, 15.3-25.2 micrograms/dl; normal, 4.5-11.0 micrograms/dl), but normal serum free t4 levels, as measured by equilibrium dialysis. their serum t3 levels ranged from 1.40-2.46 ng/ml (normal, 0.9-2.0 ng/ml). the proportion of t4 associated ...	1984	6746864
the effect of magnesium depletion on thyroid function in rats.	the effects of dietary magnesium (mg) depletion on thyroid function were studied in young male rats. the rats were fed a semipurified diet containing either 12 ppm mg (deficient rats) or 662 ppm mg (control rats) for 14 to 28 days. results showed that the mg-deficient rats had decreased body weight gain, lowered concentrations of plasma thyroxine (t4) and mg, but increased weight of the thyroid gland when expressed in proportion to the body weight (milligrams/100 g). there was no difference in t ...	1984	6747732
modulation of mutation rates in bacteriophage t4 by a base-pair change a dozen nucleotides removed.	neighboring base-pairs are known to affect site-specific mutability. a previous analysis had suggested that such effects might decrease rapidly with distance. here, however, we demonstrate a longer-range (unneighborly) base-pair effect on site-specific mutabilities: a single base-pair substitution substantially alters transition mutation rates at sites more than ten base-pairs away. dna sequencing carried out during this analysis extends the known sequence of the riia cistron by 333 residues.	1984	6748077
dna binding spectrum of the carcinogen n-acetoxy-n-2-acetylaminofluorene significantly differs from the mutation spectrum.	the 3'----5' exonuclease activity of bacteriophage t4 dna polymerase is found to be blocked in the vicinity of the n-2-acetylaminofluorene (-aaf) adducts to dna. this observation allowed us to determine the binding spectrum of the -aaf adducts along a given dna sequence. the mutation spectrum in a forward mutation assay within this same sequence has been established. comparison between the -aaf binding spectrum and the mutation spectrum shows that there is no direct correlation.	1984	6748082
t4 dna polymerase. rates and processivity on single-stranded dna templates.	three different methods have been used to determine the rate at which an individual bacteriophage t4 dna polymerase molecule moves when synthesizing dna on a single-stranded dna template chain. these methods agree in suggesting an in vitro rate for this enzyme of about 250 nucleotides per second at 37 degrees c. this rate is close to the rate at which bacteriophage t4 replication forks move in vivo (about 500 nucleotides per second). comparison with the overall amount of dna synthesis seen in in ...	1984	6748084
thyroidal changes associated with endurance training in women.	the associations between endurance training, body composition, and the pituitary-thyroid axis were studied in 17 healthy, young women. body composition and plasma concentrations of t4, t3, rt3, resin t3 uptake, tsh, and trh-stimulated tsh were examined at baseline and after each subject's weekly distance had increased 48 km (delta 48) and 80 km (delta 80) above baseline. total body weight did not change at delta 48 or delta 80. mean (+/- se) lean weight in kg increased from 42.9 +/- 1.2 at basel ...	1984	6748921
thyroid replacement in thyroparathyroidectomized dogs.	the thyroparathyroidectomized dog is an important experimental model of hypoparathyroidism and has been widely utilized for acute and chronic studies of the physiologic role of parathyroid hormone on systemic and renal acid-base, electrolyte and vitamin d physiology. despite widespread use of this model, the appropriate thyroid hormone replacement dose necessary for achievement of postoperative euthyroidism has not been established for this species. accordingly, serum thyroxine (t4) concentratio ...	1984	6749069
seasonal variations in serum levels of thyroid hormones and their relation with seminal quality and libido in buffalo bulls.	blood samples from 15 murrah buffalo bulls, (10- to 15- years-old) were collected during the summer, monsoon and winter seasons. the serum samples were analysed for thyroxine (t4) and triiodothyronine (t3) by ria. semen samples from these bulls were evaluated for various attributes. sexual behaviour of these bulls was also recorded during the different seasons and was expressed as reaction time and refusal response. t4, t3, (t4 + t3) level and t4:t3 ratio did not reveal significant difference be ...	1984	16725982
chloroplast trna gene contains a long intron in the d stem: nucleotide sequences of tobacco chloroplast genes for trna (ucc) and trna (ucu).	the nucleotide sequences of tobacco chloroplast genes for trna(gly) (ucc) and trna(arg) (ucu) have been determined. the trna(gly) gene has a 691-base-pair intron located in the d stem while the trna(arg) gene does not have any intron. the trna(gly) and trna(arg) genes are encoded on the same strand and separated by a 169-base-pair spacer. the trna(gly) gene is transcribed as a 900-base precursor rna molecule. the trna(gly) and trna(arg) deduced from the dna sequences show 84% and 55% sequence ho ...	1984	16593407
heat-labile alkaline phosphatase from antarctic bacteria: rapid 5' end-labeling of nucleic acids.	a heat-labile alkaline phosphatase has been purified to near homogeneity from hk47, a bacterial strain isolated from antarctic seawater. the active form of the enzyme has a molecular weight of 68,000 and is uniquely monomeric. the optimal temperature for the enzymatic activity is 25 degrees c. complete and irreversible thermal inactivation of the enzyme occurs in 10 min at 55 degrees c. by using this heat-labile enzyme for dephosphorylation followed by a 10-min heat treatment, rapid end-labeling ...	1984	16593525
interaction of escherichia coli b and b/4 and bacteriophage t4d with berea sandstone rock in relation to enhanced oil recovery.	much research and development is needed to recover oil reserves presently unattainable, and microbially enhanced oil recovery is a technology that may be used for this purpose. to address the problem of bacterial contamination in an oil field injection well region, we connected each end of a teflon-sleeved berea sandstone rock to a flask containing nutrient medium. by inoculating one flask with escherichia coli b, we could observe bacterial growth in the uninoculated flask resulting from the tra ...	1984	16346492
remission of hyperthyroidims and oral contraceptive therapy. [answer to question].	there is no endocrine contraindication to the use of oral contraceptives (ocs) in a 31-year-old nulliparous woman who presumably is in remission from hyperthyroidism. yet, several important physiological and pathophysiological alterations must be appreciated to evaluate properly thyroid function in persons taking estrogen-containing preparations. estrogens induce increased hepatic synthesis and release of thyroxine binding globulins (tbgs). increased serum tbg concentrations result in a new t ...	1984	12266542
effect of secondary radiation produced by 70 gev protons on dna of mammalian cells.	it is shown that the rbe of the 70 gev proton secondary radiation for the induction of single-strand break is 1.6-7.6 in chinese hamster fibroblasts and 1.04-3.8 in limphoid cells and for the lethality of chinese hamster cells 1.14-1.7. the rbe value increases with decreasing dose of the secondary radiation. on post-irradiation incubation of mammalian cells at 37 degrees c, single-strand breaks induced by the secondary radiation are repaired with the sane time course as those induced by gamma-ra ...	1984	11539632
the effect of alpha particles on bacteriophage t4br+.	it is generally accepted that heavy charged particles play an important part in generating the secondary flux of nuclear particles formed by the interaction of space hadrons with nuclei. it is assumed that these particles are responsible for the high biological efficiency of space hadrons in causing cellular damage by their strong interactions. to examine this assumption we investigated the effects of 5.3 mev alpha particles on bacteriophage t4. this energy provides a let value of 88.6 kev/micro ...	1983	11542756
degrees of relatedness of t-even type e. coli phages using different or the same receptors and topology of serologically cross-reacting sites.	the relatedness of a series of t-even like phages which use the escherichia coli outer membrane protein ompa as a receptor, and the classical phages t2, t4 and t6 has been investigated. immunoelectron microscopy and the pattern of phage resistance in bacterial mutants revealed that: (i) phages of this morphology do not necessarily cross-react serologically; (ii) phages using different receptors may bind heterologous igg everywhere except to the tip (comprising approximately 10% of one fiber poly ...	1983	11894952
toxicology and ntp carcinogenesis studies of a polybrominated biphenyl mixture (firemaster ff-1) in f344/n rats and b6c3f1 mice (gavage studies).	firemaster ff-1, a flame retardant composed of polybrominated biphenyls (pbb), was responsible for widespread environmental contamination and animal losses in michigan starting in 1973. this study was undertaken to characterize the long-term toxic and carcinogenic potential of this pbb mixture in rats and mice of each sex. fisher 344/n rats and b6c3f1 mice were given 125 oral doses of pbb over a 6-month period--0, 0.1, 0.3, 1.0, 3.0, or 10.0 mg/kg body weight/day (5 days/week). a dose-related de ...	1983	12750749
ligation of endogenous trna 3' half molecules to their corresponding 5' halves via 2'-phosphomonoester,3',5'-phosphodiester bonds in extracts of chlamydomonas.	trna preparations from chlamydomonas and wheat germ contain small amounts of trna 5' halves and corresponding 3' halves. incubation of cell-free extracts from the two sources with [gamma-p]atp yielded 5'-p-labeled trna 3' halves which were joined to their corresponding 5' counterparts to form mature trna containing 2'-phosphomonoester,3', 5'-phosphodiester bonds. trna 3' halves labelled with t4 kinase were purified, sequenced and also joined to their 5' counterparts. it is proposed that these tr ...	1983	16453445
[fasting serum gastrin, motilin and secretin in treated and untreated hyperthyroidism].	to study the gastrointestinal hormones involved in hyperthyroidism and the interrelationship with the thyroid hormones, the preprandial serum concentrations of gastrin, motilin and secretin were measured by radioimmunoassay in 33 normal subjects and in 104 patients before and after treatment. the following results were obtained. 1) serum gastrin concentrations in hyperthyroid patients were significantly higher than that of the control, and when the patients reached euthyroidism or hypothyroidism ...	1983	6617923
cervical teratomas in the newborn.	cervical teratomas are rare neoplasms which have been infrequently reported. during the period of july 1974 to april 1982, six newborns with this lesion were seen at the mott children's hospital. there were three males and three females, all of whom presented at birth with large semicystic neck masses. in four infants, calcifications were seen on x-ray. four patients required intubation within the first hours of life for respiratory distress. one child of 33 weeks gestation expired prior to oper ...	1983	6620078
[infectiousness of phage t4 frozen to -196 degrees in the presence of cryoprotectors].	polyethylene oxide with a molecular weight of 400 at a concentration of 5 to 15% and dimethyl sulfoxide at a concentration of 5% produce the protecting action when t4 phage is being frozen. the survival rate of the phage is lower when dimethyl sulfoxide at a concentration of 15% and glycerol and sucrose at a concentration from 5 to 15% are added to samples to be frozen as compared with samples frozen in the absence of the cryoprotectors.	1983	6621427
[transient biological hypothyroidism in an infant carrier of celiac disease].	this is the first report of a coeliac infant with biochemical findings of primary thyroid failure (decreased t4, decreased ft4, decreased t3, increased tsh). no clinical signs of this disorders and no thyromegaly were observed. biochemical indices of thyroid function reverted to normal after two months on a gluten-free diet. thyroid function impairment is suggested to be related with the active phase of coeliac disease.	1983	6622144
[factors affecting the serum thyroid hormone concentration during fasting in rats--with special reference to the relation with temperature].	the present studies examine the effect of starvation together with cold or hot exposure on thyroid hormone levels in rats. at 23 degrees c starved for 5 days, serum thyroid hormone levels decreased significantly compared with fed rats, averaging 3.6 +/- 0.5 micrograms/dl of thyroxine (t4), 47 +/- 11 ng/dl of triiodothyronine (t3), 1.4 +/- 0.3 ng/dl of free t4 and 39.6 +/- 5.1 pg/ml of reverse t3, respectively. at 15 degrees c rats starved for 5 days, serum free t4 level significantly more increa ...	1983	6622762
monodeiodination of thyroxine to 3,3',5'-triiodothyronine in the human placenta.	we studied the characteristics of monodeiodination of thyroxine to t3 and reverse t3 in the human placenta which was obtained at normal delivery. the placentas were homogenized in cold sucrose tris-hcl buffer, ph 7.5. the microsomal fraction was incubated at 37 degrees c in the air for 1 hr with 2 micrograms of t4 in the presence of 0.05 m dtt. the t3 and reverse t3 generated in the reaction mixture were extracted into cold ethanol and measured by ria. among the usual subcellular fractions of th ...	1983	6623461
[effect of thyroxine on the number of cells with aberrant chromosomes in the liver of rats following x-ray and neutron irradiation].	t4 effect on the quantity of cells with chromosome aberrations in rat liver under the hormone administration after x-ray irradiation was compared with that after neutron irradiation. it is shown that t4 administered after neutron irradiation does not decrease chromosome injury, which is considered as a proof of its indirect effect after x-ray irradiation by means of genetic structure reparation.	1983	6623628
concentration of plasma thyroglobulin and urinary excretion of iodinated material in the diagnosis of thyroid disorders in congenital hypothyroidism.	in this paper we describe methods for the early aetiological diagnosis of congenital hypothyroidism, using beside the classical t4, t3 and tsh plasma concentrations, four additional parameters in plasma and urine. the first one is thyroglobulin (tg). in normal children of more than one year of age and in adults, 5-35 ng/ml plasma is found, in neonates 2-3 weeks old, this level is 10-250 ng/ml. in patients with a stimulated thyroid gland, as in primary congenital hypothyroidism, plasma tg levels ...	1983	6624362
kidney structure in hypothyroidism.	hypothyroidism is associated with changes in renal function and a decrease in kidney weight. the present study was carried out for examination of the effect of the antithyroid drug aminotriazole (atz) on kidney structure and especially for determination of whether hypothyroidism affects the whole nephron or only a specific segment of it. female sprague-dawley rats received atz in their diet, 0.5 g/kg food for 4 weeks. control rats received a normal diet. additional groups of animals receiving at ...	1983	6624877
tsh-secreting pituitary tumor. a case report.	a pituitary tumor secreting thyroid-stimulating hormone (tsh) only was diagnosed in a 43-year-old man who originally showed signs and symptoms of thyrotoxicosis which recurred twice. despite normal serum levels of t3 and t4, increased levels of tsh were diagnosed. the pituitary tumor was operated by the transsphenoidal approach. morphological analysis of tumor tissue showed cellular pleomorphism and regressive changes. nuclear dna analysis showed that the tumor had only one cell line and an aneu ...	1983	6626026
[functional evaluation of cystic thyroid nodules].	7 patients (age between 22 and 52 years, mean 38.2 +/- 10.6 sd) with cystic nodules have been subjected to the same diagnostic screening (scintiscanning and echography, needle aspiration); in every subject hormonal pattern has been studied at the cyst and periphery level. the authors found very high tg levels in the cyst's fluid, perhaps due to an increased sensitiviness to the thyrotropic hormone, and an rt3/t4 increased at periphery level, probably because an enhancement of mechanisms connecte ...	1983	6626346