Publications

effect of chloride on serum thyroxine binding in familial dysalbuminemic hyperthyroxinemia.	chloride ion is known to inhibit the t4-albumin interaction in normal serum. to determine the extent of this effect on t4 binding to albumin in patients with familial dysalbuminemic hyperthyroxinemia (fdh), the serum percent free t4 (ft4) was measured by equilibrium dialysis in 0.1 m phosphate buffer, ph 7.4, and in phosphate buffer with 0.14 m nacl (phosphate-saline buffer) in patients with fdh, normal subjects, and women in the third trimester of pregnancy, who served as a population with high ...	1984	6693542
low molecular weight thyroglobulin leading to a goiter in a 12-year-old girl.	we characterized the abnormal thyroglobulin (tg) in the thyroid and serum of a 12-yr-old girl with a large sporadic multinodular goiter first noted at age 4 yr. she developed normally and had no clinical evidence of hypothyroidism. however, her serum t4 was less than 1.0 microgram/dl, t3 was 125 ng/dl, and tsh was 155 microu/ml. serum pbi was 9.7 micrograms/dl, and more than 90% was not extractable with butanol. the 24-h radioactive iodine uptake was 55%, not dischargeable by perchlorate. hormon ...	1984	6693549
a new case of familial partial generalized resistance to thyroid hormones: study of 3,5,3'-triiodothyronine (t3) binding to lymphocyte and skin fibroblast nuclei and in vivo conversion of thyroxine to t3.	a clinically euthyroid 30-yr-old man with high serum levels of both total (t4, 14.5 micrograms/dl; t3, 272 ng/dl) and free (ft4, 33 pg/ml; ft3, 9.7 pg/ml) thyroid hormones and inappropriately normal tsh levels, both basally and after trh stimulation, is described. peripheral indices of thyroid hormone action and the patient's clinical status were not modified by the prolonged administration of supraphysiological doses of both t4 (up to 900 micrograms/day) and t3 (up to 80 micrograms/day), which ...	1984	6693550
hormone and lipogenic enzyme response of the heterozygous dw chick to dietary protein level.	the growth and lipogenic responses of broiler progeny from normal (dwdw male, dw-female) and dwarf (dwdw male, dw-* female) dams to high and low dietary protein were studied. body weight gains for the dwdw compared to dwdw male progeny were greater from week 1 to 3, but less from week 7 to 8 and were similar for dw-* and dw- females. no significant effects of progeny genotype and no diet x genotype interactions were observed for feed conversion, carcass nitrogen or fat, abdominal fat, growth hor ...	1984	6693975
circulating thyroid hormone changes in acute trauma: prognostic implications for clinical outcome.	alterations in circulating thyroid hormone concentrations occur in a variety of nonthyroidal disease states. in the present study, thyroid hormone levels were measured every 8 to 12 hours in 19 otherwise healthy individuals suffering acute severe trauma necessitating admission to the maryland institute for emergency medical services systems. four fatalities occurred within 48 hours of admission. the mean total t3 level fell rapidly after the onset of trauma and remained low throughout the observ ...	1984	6694235
[hypothyroidism following intermittent administration of potassium iodide].	iodide-induced hypothyroidism with high tsh and low t4 under long term potassium iodide medication was observed in a toddler suffering from chronic wheezy bronchitis -- in spite of intermittent application. the pathophysiology of iodide-induced hypothyroidism and the apparent immaturity of adaptation to high exogenous iodide in newborn and infants are discussed.	1984	6694343
discordant changes in pituitary concentrations of lh and tsh subunits following hormonal manipulation.	we have recently shown that mouse pituitary concentrations of free tsh-beta and alpha-subunits respond divergently to thyroid hormone manipulations in vivo. this study contrasts the changes in free lh-beta and alpha-subunits after castration and polyestradiol phosphate (e2) administration with those in free tsh-beta and alpha-subunits after thyroidectomy and thyroxine (t4) administration. target hormone depletion (castration or thyroidectomy) resulted in an increase in plasma concentrations of t ...	1984	6694562
thyroid hormones and thermogenesis: the metabolic cost of food and exercise.	to mimic plasma t3 levels observed in a previous overfeeding study, six lean healthy men received replacement amounts of l-thyroxine (200 micrograms/d) to block endogenous thyroid hormone production while consuming their habitual diet. after 4 weeks equilibration on t4, l-triiodothyronine (t3) was given (45 micrograms/d) in addition to t4, to produce mild t3-thyrotoxicosis, for another 2 weeks. at the end of this period t3 was discontinued but the subjects continued to receive t4 for another 2 w ...	1984	6694567
enhanced growth and immune development in dwarf chickens treated with mammalian growth hormone and thyroxine.	the effects of growth hormone and/or thyroxine treatments on antibody production, primary lymphoid organ development, and general body growth were examined in two dwarf strains (sex-linked dwarf--sld, and autosomal dwarf--adw) and in a normal-growing strain (k) of white leghorn chickens. one-day-old male chicks were assigned to experimental groups and were treated either with thyroxine (t4) feed supplements or daily mammalian growth hormone (gh) injections or a combination of these treatments (t ...	1984	6694983
effect of thyroidectomy and thyroxine on 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) induced toxicity.	chemical thyroidectomy effectively protected athyroid rats from mortality during 45 days after dosing with 100 micrograms 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)/kg, whereas 70 to 80% of nonthyroidectomized-euthyroid and thyroidectomized-t4 (thyroxine)-maintained-euthyroid rats died within the same period of time. there was a significant decrease in body weight of all tcdd-treated groups compared to vehicle controls. however, body weight loss was much slower in thyroidectomized-athyroid (cong ...	1984	6695381
[treatment of penile cancer].	the results of treatment of 252 cases of cancer of the penis were evaluated. indications for available methods of treatment with regard to patient's age, stage and size of primary tumor were worked out. conservative treatment should be given to cases of t1 and t2 tumors, combined treatment--t3, and palliative therapy--t4 neoplasms. an experience with cryodestruction of tumor in combination with chemotherapy is discussed. more advantage seems to be offered by application of radiation treatment in ...	1984	6695529
effect of neonatal hyperthyroidism upon the regulation of tsh secretion in rats.	the neo-t4 syndrome was induced in rats by administration of 30 micrograms t4/in 5 doses starting on the first day of life. in the first experiment (a), neo-t4 and saline-control rats were divided into two populations, one of which was thyroidectomized on day 25. all rats then received 5 micrograms t4/100 g b.w. on days 42, 43 and 44, and were sacrificed on day 45. in the second experiment (b), neo-t4 and saline-control rats were thyroidectomized at 25 days of age and were sacrificed 10, 20 and ...	1984	6695542
changes in the multiple components of rat pituitary tsh and tsh beta subunit following thyroidectomy.	heterogeneity of pituitary tsh was investigated in rats following thyroidectomy. adult male rats were sacrificed at varying periods (2-28 days) after thyroidectomy. in another experiment, thyroidectomized rats were injected daily with various doses of l-t4 (0.3-7.5 micrograms/100 g body weight, ip) and sacrificed 2 weeks later. the homogenate of the pituitaries was applied on an isoelectric focusing column or a sephacryl s-200 column. the normal rat pituitary contained 5 major components of immu ...	1984	6695544
effects of intrathyroidal metabolism of thyroxine on thyroid hormone secretion: increased degradation of thyroxine in mouse thyroids stimulated chronically with thyrotrophin.	mice were infused continuously with graded doses of bovine tsh (btsh) and changes in plasma concentrations of btsh and t4 were measured. then mice infused with 100 mu tsh per day were sacrificed on days 0, 1, 3 and 5 and their thyroids were excised to determine in vitro secretion of t4, t3 and rt3 during 3 h of incubation. at the end of the incubation, thyroidal contents of t4, t3 and rt3 were also determined after pronase digestion. plasma btsh levels were increased on day 1 to a level of 110 m ...	1984	6695545
the effect of d,l-4-hydroxypropranolol on the thyroxine to 3,5,3'-triiodothyronine conversion in rat renal and liver microsomes.	the in vitro effect of d,l-4-hydroxypropranolol, a major pharmacological active metabolite of the beta adrenoceptor blocking drug d,l-propranolol, on the thyroxine (t4) to 3,5,3'-triiodothyronine (t3) conversion has been studied using rat renal and liver microsomal fractions. the results showed, that primarily the metabolite, but also the parent drug inhibits the t3-production in a dose dependent manner. the potency, expressed as the 50% inhibition of the t3-production, was reached using 65 +/- ...	1984	6695551
effect of thyroxine administration on phosphate transport across renal cortical brush border membrane.	previous studies indicate that in hyperthyroid states the renal tubular reabsorption of phosphate is enhanced. to determine the cellular basis of this phenomenon, we investigated the effect of l-thyroxine (t4) administration on pi transport across brush border membrane vesicles (bbmv) from rat renal cortex. rats were thyroparathyroidectomized, fed a diet containing 1.2% phosphate, and treated intraperitoneally for 6 days with 200 micrograms t4 x 100 g body wt-1 x day-1. at the end of the treatme ...	1984	6696115
effects of a large dose of retinol or retinoic acid on the thyroid hormones in the rat.	the daily food intake of a large dose of retinol (as palmitate) or retinoic acid (as all-trans retinoic acid) modifies numerous parameters of the thyroidal status in the rat. there were decreases of the serum total thyroxine (tt4) and triiodothyronine (tt3), and of the biological half-life of t4, while there were increases of the dialyzable fractions of t4 and t3 and of the apparent distribution space of t3. the possible causes of these changes are discussed.	1984	6696397
the importance of reverse triiodothyronine in hypothyroid children on replacement treatment.	reverse triiodothyronine (rt3), triiodothyronine (t3), thyroxine (t4), and thyroid stimulating hormone (tsh) values were measured by radioimmunoassay in 40 children with congenital hypothyroidism who were being given levothyroxine (0.05-0.35 mg/day) and in 14 normal controls. in 15 of the children with hypothyroidism the treatment, judged by serum t4 and tsh values and thyrotrophin releasing hormone (trh) test, seemed to be adequate and their mean rt3 value and rt3:t4 ratio were comparable with ...	1984	6696490
serum thyroid hormone indexes in patients with primary hyperparathyroidism.	serum total reverse triiodothyronine (rt3) levels are normal in patients with renal diseases with and without renal insufficiency but elevated in nonrenal nonthyroidal illnesses. to evaluate the role of secondary hyperparathyroidism of renal diseases in this difference, serum thyroid hormone levels were studied in 27 patients with primary hyperparathyroidism (php) and normal renal function. in php, total t3 levels were reduced (118 +/- 6 ng/dl, normal: 147 +/- 3 ng/dl) and correlated with pth le ...	1984	6696568
influence of thyroid hormone on some electrophysiological properties of developing rat skeletal muscle cells in culture.	effects of thyroxine (t4) were examined on some electrophysiological properties of developing rat myotubes in culture. thyroxine caused an increase in transmembrane resting potential (em) of skeletal myotubes. ouabain decreases em in both control and t4-treated cells within 5-15 min of addition to the culture. moreover, the effect of t4 is nearly eliminated by short-term ouabain treatment and by reduced extracellular k+ concentration. the change in em in response to a 10-fold increase in extrace ...	1984	6697244
primary mucoepidermoid carcinoma in the thyroid gland. a case report including an ultrastructural and biochemical study.	an extremely rare mucoepidermoid carcinoma of the thyroid gland was found in a 44-year-old woman. by light microscopic examination, the tumor consisted of mucous cells and squamoid cells, and was similar to that occurring in any other organs. by electron microscopic examination, the mucous cells displayed prominent mucous droplets, and showed no evidence of colloid production in their cytoplasms. abundant tonofilaments in aggregates were observed in the squamoid cells. biochemically, thyroxine ( ...	1984	6697313
32p-postlabeling test for covalent dna binding of chemicals in vivo: application to a variety of aromatic carcinogens and methylating agents.	carcinogen--dna adducts were detected and determined by 32p-postlabeling assay after exposure of mouse or rat tissues in vivo to a total of 28 compounds comprising 7 arylamines and derivatives, 3 azo compounds, 2 nitroaromatics, 12 polycyclic aromatic hydrocarbons, and 4 methylating agents. dna was isolated from mouse skin, mouse liver, and rat liver after treatment with the individual carcinogens, then digested enzymatically to deoxyribonucleoside 3'-monophosphates, which were converted to 5'-3 ...	1984	6697441
progress report on a national quality-control survey of triiodothyronine and thyroxin assay.	in january 1980, a national external quality-control survey was organized to evaluate assays for triiodothyronine (t3) and thyroxin (t4). currently, about 150 laboratories are involved. each participant has received and assayed 100 quality-control samples during four periods of about six months each. the average analytical performance achieved by the participants in each six-month period was estimated by computing the average between-laboratory agreement (cvt), the overall average bias, and the ...	1984	6697485
iatrogenic hyperthyroidism secondary to dextrothyroxine administration.	two patients are reported who presented with clinical hyperthyroidism, increased serum thyroid function studies, and depressed radioactive iodine uptake, secondary to chronic ingestion of d-t4. symptoms abated, and function studies returned to normal, following discontinuation of d-t4. this uncommon effect of d-t4 may be more prevalent than is generally realized and must be recognized as another potential cause of low radioiodine uptake in patients with clinical hyperthyroidism.	1984	6697613
comparative study on the secondary structure of lysozymes from different sources.	the secondary structure of 16 type c lysozymes, 2 type g lysozymes, phage t4 lysozyme and bovine alpha-lactalbumin have been estimated according to the method of chou and fasman (1978). the prediction has been done on the partial sequence of lysozymes from three insects and tortoise egg-white lysozyme. from these studies, patterns of common secondary structure domains on lysozymes have been developed. these patterns have been compared attending to the active site and the antigenic loop of the he ...	1984	6697687
evidence that the 5'-monodeiodinases for thyroxine and 3,3',5'-triiodothyronine in the rat pituitary are separate enzymes.	studies were directed at the question of whether the enzyme that mediates the 5'- or outer ring monodeiodination of t4 is the same as that which mediates the 5'-monodeiodination of rt3. advantage was taken of previous observations which indicated that t3, when administered to the hypothyroid rat, acutely inhibits the 5'-monodeiodination of t4 to yield t3 in hemipituitaries in vitro. in the present experiments, these effects of t3 on the generation of t3 from t4 were confirmed in both hemipituita ...	1984	6697961
intraluminal iodination of thyroglobulin.	the intraluminal distribution of newly synthesized (injection of [3h]leucine) and newly iodinated (injection of na125i) proteins in thyroids of rats given t4 for 2 days was studied with quantitative electron microscopic autoradiography. three, 4.5, and 6 h after [3h]leucine about 90%, 85%, and 65%, respectively, of the luminal label was confined to the microvillus region. this distribution differed from that of newly iodinated protein; already 2 min after injection only about 30% of the grains w ...	1984	6697965
relationship of antral gastrin cells and serum gastrin to thyroid function in the rat.	using a quantitative immunocytochemical technique, antral gastrin cell populations in the rat were studied in various states of thyroid function. simultaneous determinations of circulating serum gastrin were made by ria. rats made hypothyroid by ingestion of methimazole (0.01% solution in drinking water for 30 days) demonstrated a significant 32% decrease in gastrin cell density (306 +/- 9/cm vs. 207 +/- 11/cm for controls) associated with a significant 50% decrease in serum gastrin (143 +/- 12 ...	1984	6697967
stimulation of phospholipid methylation and thyroid hormone secretion by thyrotropin.	synthesis of phosphatidylcholine (pc) by s-adenosylmethionine-dependent methylation of phosphatidylethanolamine has previously been associated with receptor-mediated histamine and pituitary hormone secretion. we investigated stimulation of phospholipid methylation by tsh and its possible role in thyroid hormone secretion. rat hemithyroids were incubated in krebs-henseleit-glucose-bsa buffer and the effect of various treatments on the incorporation of [3h-methyl]l-methionine into pc and t4/t3 sec ...	1984	6697969
effect of hypothyroidism and hyperthyroidism on triiodothyronine production in perfused rat liver.	this study was undertaken to evaluate the effect of altered thyroid states on hepatic t3 production in a functioning intact organ system, the isolated perfused liver. thyroidectomized rats were treated for 3-4 weeks with vehicle, t4, 1.5 micrograms/100 g-1 day-1, or t4, 20 micrograms/100 g-1 day-1, to produce hypothyroidism, euthyroidism, or hyperthyroidism. livers were perfused for 1 h with medium containing t4, 10 micrograms/dl, and t3 production was estimated by ria. t3 production in the hypo ...	1984	6697973
relationship of thyroid hormone patterns to survival in canine hemorrhagic shock.	6 of 13 dogs subjected to 1 h of hemorrhagic shock (bp = 45-50 mm hg) died during the first convalescent day. nonsurvivors had lower baseline plasma concentrations of total and free t4 and t3, as well as rt3, and higher t3 uptake values. during shock, dogs that died had significantly lower plasma levels of total and free t4 and t3 and higher t3 uptake. in general, intergroup differences were accentuated during resuscitation. after volume replenishment, indices of thyroid function had stabilized ...	1984	6698080
respective roles of circulating t4 and t3 in control of tsh secretion in severely iodide-deficient rats.	after a 6-month iodide deficiency, wistar male rats were submitted to a normal iodine diet (20 and 50 micrograms of 127i daily). plasma t3, t4 and tsh were determined by ria from 0 to 140 days of iodide refeeding. a highly significant correlation was found between plasma tsh and t4 concentrations, but not between plasma tsh and t3 levels. these data suggest that an increase in plasma t3 alone, up to the normal value, is not able to inhibit tsh secretion. it is only when a certain plasma t4 conce ...	1984	6698180
regulation of plasma t3 levels in t4-challenged rainbow trout, salmo gairdneri.	levels and kinetics of plasma t3 (3,5,3'-triiodo-l-thyronine) and t4 (l-thyroxine) were studied in rainbow trout injected intraperitoneally with carrier t4. plasma t4 levels were increased almost fivefold by a t4 dose of 9.4 ng/g body wt given 24 hr earlier, and almost 50-fold by a dose of 69 ng/g. however, neither treatment altered plasma t3. t4 injection did not alter significantly the metabolic clearance rates of plasma t4 and t3 or [125i]t4 uptake by liver, intestine, and gall bladder, but r ...	1984	6698386
thyroid hormone changes in the bobwhite (colinus virginianus) after hatching.	total concentrations of thyroxine (t4) and triiodothyronine (t3) in plasma, and their biological half-lives were measured in adult and immature bobwhite. concentrations of t4 and t3 decreased approximately 75% from days 1 to 10 after hatching. after day 10, the concentration of t4 did not significantly change as a function of age; however, the concentration of t3 doubled from day 21 (275 ng/dl) to day 29 (550 ng/dl) after hatching and remained significantly elevated above adult level (300 ng/dl) ...	1984	6698393
effect of methadone on tsh and thyroid hormone secretion.	the hypothalamus-pituitary-thyroid function was studied in 15 male patients on chronic methadone treatment (40 mg/day). no significant variations of tsh, t4, t3 and rt3 levels were documented, either in basal conditions or after trh stimulation; however a reduced tsh pituitary response was recorded in some patients (6 out of 15).	1984	6698493
endemic goitre, nutrition, and landholding in bangladesh.	endemic goitre in adult females, cretinism, and anthropometry in children were examined in a goitrous area of bangladesh. an area survey showed total goitre varying from 62.0 to 93.0%, visible goitre from 9.0 to 54.8% between areas. a village study examining thyroid size in 538 adult females and anthropometry in 116 children showed goitre prevalences varying significantly (p less than 0.001) but unpredictably with household landholding size; underweight and wasting varied inversely and significa ...	1984	6698705
influence of cigarette smoking on goiter formation, thyroglobulin, and thyroid hormone levels in women.	the possible influence of cigarette smoking on goiter formation, thyroglobulin (tg) secretion, and thyroid hormone production was assessed by estimations of the presence of palpable goiter and by rias of tg, t3, rt3, t4, and tsh in sera from 441 women (48-53 yr old), representing a normal population included in a study on the prevalence of thyroid disease. smoking habits were evaluated by a questionnaire, and the women were then classified as never smokers (n = 192), smokers (n = 169), and exsmo ...	1984	6699129
use of bromocriptine in a patient with generalized resistance to thyroid hormone.	a 50-yr-old man with a large goiter had elevated serum levels of t4 (22 micrograms/dl), t3 (228 ng/dl), and free t4 (6.6 ng/dl), a high 24-h 131i-thyroidal uptake (69%), and an elevated tsh level (3.6 microu/ml), as well as hyperresponsiveness of tsh to trh (peak tsh, 47 microu/ml). normal serum alpha-subunit concentrations and sella turcica films mitigated against the presence of a pituitary tumor. a normal basal metabolic rate and minimally elevated concentration of testosterone-estradiol bind ...	1984	6699135
influence of methimazole on murine thyroiditis. evidence for immunosuppression in vivo.	thionamide drugs are immunosuppressives in vitro. to examine this action in vivo, a/j mice were immunized with human thyroglobulin (htg) (0.5 mg intraperitoneal injections for 5 d) beginning on days 6, 24, and 43 with or without methimazole (m) (0.05%) and l-thyroxine (t4) (0.1 micrograms/ml to prevent thyroid hypertrophy) in their water supply. groups (n = 8) were killed on days 37, 42, and 59. spontaneous splenic igg-secreting cells determined by staphylococcus protein a-linked sheep erythrocy ...	1984	6699171
peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man.	the present study was undertaken to define the source of endogenous triiodothyronine (t3) production responsible for maintaining serum t3 levels in euthyroid subjects with depressed serum thyroxine (t4) values. after withdrawal from 4 wk of exogenous t3 administration, a 22% decline in serum t3 values (from 129 +/- 6 to 99 +/- 4 ng/dl) was observed in six euthyroid subjects, despite a twofold reduction in serum t4 concentrations (from 7.5 +/- 0.5 to 3.2 +/- 0.5 micrograms/dl). this was accompani ...	1984	6699177
lean body mass is a predictor of the daily requirement for thyroid hormone in older men and women.	levothyroxine (t4) replacement need in adults with primary hypothyroidism has recently been reported to fall with age. previous studies have demonstrated that the resting metabolic rate falls with age in euthyroid adults and that this fall is proportional to a reduction in lean body mass (lbm). since lbm is correlated also with 24-hour energy expenditure, this study examined the possibility that lbm might be an accurate predictor of t4 requirement. seventy-five hypothyroid adults receiving full ...	1984	6699335
greater splanchnic excitation of primate t1-t5 spinothalamic neurons.	effects of electrical stimulation of the left greater splanchnic nerve (spl) on t1-t5 spinothalamic (stt) neurons were determined. eighty-five stt neurons were studied in 36 anesthetized monkeys (macaca fascicularis). all neurons were excited by manipulation of their somatic receptive fields and by electrical stimulation of cardiopulmonary (cp) sympathetic afferent fibers. spl stimulation excited 63 (74%) stt neurons. there was an increasing percentage of cells with spl input at more caudal segm ...	1984	6699679
t4-induced antipolarity: temporal heterogeneity in response of early transcription units.	when t4 infects escherichia coli in the absence of protein synthesis, rho-mediated termination takes place on early polycistronic transcription units. during the early period of development, the appearance of delayed early transcripts becomes insensitive to the inhibition of protein synthesis. in the absence of the t4 gene product mot, an inducer for the middle mode of transcription, only the early polycistronic messengers are synthesized. in mot- -infected cells, the synthesis of the distal tra ...	1984	6699944
involvement of the thyroid gland in the response of young chickens to heat stress.	the involvement of the thyroid gland in the response of young chickens to heat stress was studied. mean survival times when exposed to 50 c were significantly shorter for 3-week-old broiler male chickens injected with 40 micrograms l-thyroxine (t4)/100 g body weight compared to chickens injected with 30, 20, or 0 microgram of t4/100 g body weight. a significant reduction in heat stress survival time was obtained when t4 was injected 12, 18, or 24 hr before heat stress but not 6 hr before. triiod ...	1984	6701144
thyroid antibodies in blood donors: prevalence and clinical significance.	in sera from 1643 randomly selected blood donors examined in 1979 thyroglobulin antibodies (tga) were found in 3.4% and thyroid microsomal antibodies (tma) in 7.0%. tma, but not tga, showed significant sex and age relationships. eight-two donors with tma titres greater than or equal to 1600 and/or tga titres greater than or equal to 128 were available for a follow-up study in 1982. in 69 of these with tma there was a significantly increased incidence of pathological thyroid function-test values ...	1984	6702401
effects of propranolol on thyroid function in the dog.	the effect of propranolol on thyroid function was evaluated in 6 mature euthyroid beagles. propranolol was administered orally in doses of 20 mg given 3 times daily for 2 weeks and then increased to 40 mg given 3 times daily for an additional 2 weeks. six age- and sex-matched, euthyroid beagles served as controls. serum base-line concentrations of tetraiodothyronine (t4), triiodothyronine (t3), and reverse triiodothyronine (rt3) were measured before propranolol administration and at weekly inter ...	1984	6703443
clinical and chemical assessment of thyroid function during therapy with amiodarone.	clinical and chemical variables of thyroid function were studied in 26 patients with symptomatic ventricular tachyarrhythmias before and during long-term oral treatment with amiodarone. the mean (+/-sem) pretreatment thyroxine (t4) level in the 26 patients was 7.32 +/- 0.33 micrograms/dl, and increased notably to 10.15 +/- 0.47 micrograms/dl by 30 to 120 days after treatment. the free thyroxine index (ft4i) was also notably elevated. clinical hyperthyroidism or goiter did not develop, but clinic ...	1984	6703817
thyroid activity in cigarette smokers.	recent studies have shown a possible relationship between cigarette smoking and endocrine function. since changes in thyroid hormone concentrations can have a profound effect on overall metabolism as well as influencing both androgenic and estrogenic steroid activity, we investigated the relationship between cigarette smoking and thyroid function. volunteers were divided into four groups according to self-reported and biochemical data, including blood carboxyhemoglobin, plasma cotinine, and thio ...	1984	6703821
the isolation of identical thyroxine containing amino acid sequences from bovine, ovine and porcine thyroglobulins.	identical, thyroxine containing tryptic peptides have been isolated from digests of bovine, ovine and procine thyroglobulins. this 19 residue hormone containing sequence, nh2-asn-ile-phe-glu-t4-gln-val-asp-ala-gln-pro-leu-arg-pro-cys-glu-leu-g in-arg- cooh, is completely conserved across these three species, and it represents a principal site of thyroxine synthesis. hplc maps of tryptic digests of the thyroglobulins have been monitored at several wavelengths and suggest that, in each case, only ...	1984	6704086
energy metabolism and body composition of young pigs given low-protein diets.	the energy metabolism of young pigs offered low-protein diets to appetite or a normal starter (diet 1, 225 g crude protein (nitrogen x 6.25; cp)/kg dry matter (dm] to maintain zero energy balance was studied using indirect calorimetry and slaughter. the treatments were: t1, diet 1; t2, 46 g cp/kg dm; t3, 21 g cp/kg dm; t4, 17 g cp/kg dm; t5, 21 g cp/kg dm and no supplemental thiamin. daily heat production (kj/d per kg body-weight (w)0.75) declined on all treatments from a pre-experimental value ...	1984	6704370
[interaction of dna and rna ligases of phage t4 with cibacron blue f 3ga].	using kinetic methods and differential spectrophotometry, the interaction between dna and rna ligases t4 and cibacron blue f3ga was studied. it was shown that the dye inhibits the first step of the enzymatic reaction, i. e. the formation of the amp ligase complex. a 50% inhibition of the amp-ligase complex by dna ligase occurs at the dye concentration of 1 x 10(-5) m, that by rna ligase--at 1 x 10(-4) m. cibacron blue f3ga also inhibits the formation of end products of the reaction catalyzed by ...	1984	6704448
primary irradiation in the management of early and locally advanced carcinoma of the breast.	between september 1, 1974, and july 31, 1979, we have treated 142 patients with a diagnosis of carcinoma of the breast by a combination of megavoltage external irradiation and interstitial iridium-192 implant. sixty-four patients had t1 and t2 lesions and 78 patients had t3 and t4 lesions of the breast. since june 1977, pre- and perimenopausal patients with t1 and t2 lesions have undergone axillary node dissection in addition to excisional biopsies of the breasts. all patients received external ...	1984	6704663
high-dose radiation therapy in carcinoma of the pyriform sinus.	in a retrospective analysis of 61 patients with carcinoma of the pyriform sinus, treated primarily with high doses of radiation therapy with surgery reserved for persistent or recurrent tumor, survival rates of 56.5% and 12.4% were found in stages iii and iv, respectively. the two patients with stage ii disease were cured. there were no stage i patients. the local control of t4 lesions and n2-3 lesions, as well as the survival of patients with stage iv disease, is poor with radiation alone. this ...	1984	6704897
[characteristics of the molecular organization of the short fibrils of bacteriophage t4].		1984	6705684
a radioimmunoassay of 3,5-dimethyl-3'-isopropyl-l-thyronine.	a simple, sensitive, and specific ria has been developed to measure 3,5-dimethyl-3'-isopropyl-l-thyronine (dimit) in unextracted serum. the ria employs a dimit-binding antibody obtained from a rabbit immunized with dimit-human serum albumin conjugate and [125i]t3 as the radioligand. 8-anilino-1-naphthalene sulfonic acid and barbital buffer (0.075 m; ph 8.6) were used to minimize serum binding of dimit and [125i]t3. the detection threshold of the ria was 0.03 microgram/dl. recovery of nonradioact ...	1984	6705739
autoregulation by iodine of thyroid protein synthesis: influence of iodine on amino acid transport in cultured thyroid cells.	studies were conducted to determine whether the inhibitory effect of iodine on thyroid protein synthesis could be explained by a reduction in intracellular amino acid transport. the nonmetabolizable amino acid [14c]cycloleucine was used as a probe for the l system of neutral amino acid transport in dog thyroid cells during the initial 24 h of primary culture. uptake of cycloleucine was linear for up to 30 min. at all time points, cycloleucine transport was reduced in cells preincubated for 3 h i ...	1984	6705741
effect of 3,5,3'-triiodothyronine-induced hyperthyroidism on iodothyronine metabolism in the rat: evidence for tissue differences in metabolic responses.	we studied the effect of t3-induced hyperthyroidism on the outer ring (5' or 3') monodeiodination of t4 (to t3) and 3',5'-diiodothyronine [3',5'-t2; to 3'-monoiodothyronine (3'-t1)] and on the inner ring (3 or 5) monodeiodination of 3,5-t2 (to 3-t1) by various rat tissues. weight-matched pairs of male sprague-dawley rats were given either saline or t3 (20 micrograms/100 g bw daily) ip for 3 days. the metabolism of the iodothyronines was studied on day 4 in homogenates of the tissues in the prese ...	1984	6705742
n6-methyldeoxyadenosine 5'-triphosphate as a probe of the fidelity mechanisms of bacteriophage t4 dna polymerase.	the incorporation of m6datp by t4 dna polymerase has been investigated. unlike escherichia coli dna polymerase i (engel, j.d., and von hippel, p.h. (1978) j. biol. chem, 253, 935-939), the t4 enzyme discriminates at the insertion step against the methylated triphosphate as compared to the normal substrate (datp). the apparent km values measured in two ways agree with the overall 7-fold discrimination measured in double label experiments. the apparent vmax values measured for net dna synthesis ar ...	1984	6706972
decreased thyroid gland volume in alcoholic cirrhosis of the liver.	thyroid function and thyroid gland volume were studied in 40 consecutive alcoholic patients with histologically proven cirrhosis of the liver, and compared with data obtained from 40 sex-, age-, and weight-matched normal subjects. thyroid volume, measured ultrasonically, was significantly decreased in the patients with cirrhosis: median, 11 ml (range, 6-16 ml); compared to normal subjects: median, 20 ml (range, 10-31 ml) (p less than 0.001). serum t3 concentrations were significantly reduced: me ...	1984	6707193
bromocriptine therapy for hyperthyroidism due to increased thyrotropin secretion.	we describe a patient with tsh-induced hyperthyroidism successfully treated with bromocriptine. a 25-yr-old woman was found to have hyperthyroidism due to excessive tsh secretion; no pituitary tumor was found. her serum t4 level ranged between 21.9 and 25.9 micrograms/dl and that of t3 between 283 and 314 ng/dl. serum tsh was between 5 and 9 microu/ml with an exaggerated response to trh. basal metabolic rate was +26 to +38%. serum prl was also elevated (79 ng/ml). administration of bromocriptine ...	1984	6707194
qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats.	propylthiouracil (ptu) in maximally inhibitory doses for liver and kidney iodothyronine 5'-deiodinase activity (5'd-i), reduces extrathyroidal t4 to t3 conversion by only 60-70% in euthyroid rats. a second pathway of t4 to t3 conversion (5'd-ii) has been found in pituitary, central nervous system, and brown adipose tissue. 5'd-ii is insensitive to ptu and increases in hypothyroidism, whereas 5'd-i decreases in hypothyroid rats. thyroxine (t4) and triiodothyronine (t3) kinetics were assessed in e ...	1984	6707210
control of thyroglobulin secretion from the rat thyroid gland.	serum thyroglobulin (tg), measured by radioimmunoassay, was high in 6-propylthiouracil (ptu)-treated rats but low in thyroxine (t4)-treated animals compared with euthyroid controls. thyroid-stimulating hormone (tsh) stimulated tg release in vitro from enzymatically dispersed normal rat thyroid cells in a dose-dependent manner. thyroid cells prepared from t4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of tg from thyroid cells prepared from ptu-trea ...	1984	6707550
characteristics of infantile hypothyroidism discovered on neonatal screening.	clinical and laboratory data from 146 patients with infantile hypothyroidism diagnosed by neonatal screening over a five-year period are presented. in 95 patients there was adequate thyroid imaging or evidence of dyshormonogenesis; of these, 43% had ectopic thyroid tissue, 22% had goitrous hypothyroidism, and 35% had hypoplastic or aplastic glands. stanford-binet iqs of the patients at 3, 4, and 5 years of age were identical with those of control subjects. patients in whom thyroid tissue was dem ...	1984	6707815
incidence of hypothyroidism following multimodality treatment for advanced squamous cell cancer of the head and neck.	the incidence of chemical hypothyroidism, as manifested by elevated thyroid stimulating hormone (tsh) levels, has been estimated to be as high as 25% after radiation therapy and 45% after radiation therapy and surgery to the neck for treatment of nodal metastases from squamous carcinoma of the head and neck. we prospectively evaluated 43 previously untreated patients seen in the dana farber cancer institute interdisciplinary head and neck service who were treated with aggressive combination chem ...	1984	6708688
propylthiouracil, ipodate, dexamethasone and periods of fasting induce different variations in serum rt3 in dogs.	fasting or administration of propylthiouracil (ptu), ipodate, or dexamethasone are all known to induce a pattern of low serum triiodothyronine (t3) concentrations and high serum reverse t3 (rt3) concentrations in humans. in the present study it was found that this is not a universal phenomenon. in normal dogs exposed to fasting or these various pharmacologic agents, the serum t3 level was always depressed as in humans. however, different variations in serum rt3 levels were observed. fasting and ...	1984	6708815
[dna-like duplexes containing repetitive sequences. vii. chemico-enzymatic synthesis of polymers with fragments of natural promotors].	two types of dna-duplexes containing the repeating fragments of natural promoters have been obtained starting from synthetic oligodeoxyribonucleotides tgcattataa, aactagtt, agttaact. deca- and octanucleotides have been synthesized by solid phase method with stepwise or blockwise chain elongation. uv- and cd-spectroscopy has been used to study the physico-chemical properties of the synthetic oligonucleotides. polycondensation of oligonucleotides induced by water-soluble carbodiimide (chemical lig ...	1984	6708955
synthesis, complete 1h assignments and conformations of the self-complementary hexadeoxyribonucleotide [d(cpgpaptpcpg)]2 and its fragments by high field nmr.	the two deoxyribonucleotides [d(cpgpaptpcpg)]2 and [d(cpgpcpg)]2 were synthesized by the phosphotriester method. their duplex form under the conditions of the 1h-nmr experiments was proven by end 32p labeling with t4 polynucleotide kinase followed by butt end joining employing the absolute specificity of t4 ligase for double stranded dna and analysis using gel electrophoresis and autoradiography. complete nmr assignment of the 1h chemical shifts and coupling constants was achieved. the assignmen ...	1984	6709499
growth hormone, thyroxine, and triiodothyronine levels of japanese quail selected for four-week body weight.	plasma growth hormone (gh), triiodothyronine (t3), and thyroxine (t4) levels were compared in four lines of japanese quail (c,p,t, and s) from 1 to 4 weeks of age in two experiments. lines p and t were derived from line c by 59 generations of selection for high 4-week body weight. line p was selected under the same nutritional regimen as line c (28% protein) while line t was selected under a restricted protein (20%) ration containing .2% thiouracil. line s was developed as a subline from t by co ...	1984	6709562
teratogenicity of nitrofen (2,4-dichloro-4'-nitrodiphenyl ether) and its effects on thyroid function in the rat.	nitrofen is a herbicide with potent teratogenic activity in rodent species. previous studies have indicated that this agent has a stereochemical structure similar to thyroid hormone, and that exposure of adult mice results in depression of thryoxine (t4) levels. the present study was undertaken to determine if teratogenic exposure to nitrofen alters pituitary-thyroid function in nonpregnant, pregnant, and fetal rats, and if these potential alterations could be related to induction of birth defec ...	1984	6710532
[therapy and prognosis of penile cancer].	a report is given on the therapy and prognosis of 38 patients with carcinoma of the penis. prognosis depends on the extent and histological structure of the tumours. for small tumours (t1n0m0) methods of operation which conserve the organ (circumcision, extirpation of the tumour) combined with cryosurgical procedures have proved to be sufficient. however, most cases (t2 and t3 tumours) require amputation 1.5 to 2 cm into the healthy tissue. if lymph nodes are palpable, regional lymphadenectomy m ...	1984	6711160
caudal anaesthesia for upper abdominal surgery in infants and children: a simple calculation of the volume of local anaesthetic.	where the use of non-depolarizing muscle relaxants and antagonists is undesirable in infants and children undergoing abdominal surgery, caudal anaesthesia is frequently adopted, combined with light general anaesthesia. a simple calculation has been derived to determine the volume of local anaesthetic needed to obtain a higher effective anaesthetic level (up to t4-5) for upper abdominal operations using caudal anaesthesia. clinically, a linear correlation was found between an empirically injected ...	1984	6711263
regional pancreatectomy for cancer of the pancreas, ampulla, and other related sites. tumor staging and results.	regional pancreatectomy refers to an en bloc removal of a tumor in or adjacent to the pancreas with an adequate soft tissue margin and with its regional lymphatic drainage. the pancreatic segment of portal vein is part of the en bloc resection with venous reconstruction by end-to-end anastomosis without a graft. this operation, called a type i regional pancreatectomy, may utilize either a total or subtotal removal of the pancreas. localized arterial involvement by a neoplasm necessitates adding ...	1984	6712317
changes in blood chemistry in hypertensive patients during propranolol therapy.	propranolol induced changes in blood plasma chemistry were followed in thirty hypertensive patients (who i-ii) who were seen each week during 14-15 weeks. the initial 4 weeks were a drug free period and the next 2 weeks were a drug adjustment period. after that the patients were on an unchanged propranolol dose for 8 weeks (40, 80 or 160 mg four times daily). for all observed changes the correlation was studied to (1) dose, (2) free and total simultaneously determined plasma concentration and (3 ...	1984	6712860
effect of leucogenenol, a thymothyroid hormone, on the growth of immature and neonatally thymectomized rats.	the reports of early investigators that growth is delayed by thymectomy of immature animals have been confirmed. although growth is delayed by thymectomy, thymectomized animals approach asymptotically with age the same final weight as corresponding intact animals. treatment with leucogenenol, a thymothyroid hormone, accelerates the rate of growth of immature neonatally thymectomized rats to that of normal rats. however, treatment with leucogenenol does not increase the rate of growth of normal r ...	1984	6713283
elevated serum thyroglobulin as a manifestation of acute haemorrhage into the thyroid gland.	clinical observations and serial determinations of serum thyroglobulin (tg) were made in five patients with acute haemorrhage into the thyroid gland. fever, local pain and acceleration of erythrocyte sedimentation rate were minimal or were not observed, and serum t4 and t3 were normal. although all patients showed an increase in serum tg, this was most obvious in three subjects and it gradually decreased as the nodule became smaller. there was no correlation between the serum tg concentration an ...	1984	6713690
gastric secretion and emptying in hypothyroidism.	hypothyroidism is commonly thought to cause decreased gastric emptying and secretion, but these may be related to associated autoimmune disease or chronic changes. therefore, we measured gastric emptying and secretion in 11 healthy controls and in nine patients (19-54 years old; five females and 4 males) rendered athyreotic by surgery and/or 131i for thyroid cancer. replacement t4 was stopped 47-65 days and subsequent replacement t3 was stopped 33-40 days before the study. all patients were symp ...	1984	6714056
iodothyronine deiodination reaction types in several rat tissues: effects of age, thyroid status, and glucocorticoid treatment.	two types of iodothyronine 5'-deiodination have been characterized previously in rat tissues. they can be distinguished by inhibition of type i but not type ii by 6-n-propylthiouracil, by the relative suitability of t4 and rt3 as substrates, rt3 much better than t4 for type i and t4 as good as, or better than, rt3 for type ii, and by the concentration of t4 required to inhibit deiodination of rt3, 1-10 microm for type i and 1-10 nm for type ii. type i activity (6-n-propylthiouracil sensitive) is ...	1984	6714153
effect of iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl.	accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by t. f. davison, j. g. rowell, and j. rea, [1981) j. endocrinol. 89, 371-378). radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg ki/liter) or injections of thyroxine (t4: 5 x 50 micrograms t4/kg body wt), in agreement with published findings. treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125i up ...	1984	6714654
erythropoietin, testosterone, and thyroxine in the erythropoietic response of the snake, xenochrophis piscator.	the erythropoietic response of snakes was examined after injecting human urinary erythropoietin (ep), testosterone propionate (tp), and l-thyroxine (t4), separately and in combinations, into starved ophids. the effect of starvation was reflected by a decrease in the number of erythrocytes, a fall in hemoglobin concentration, and a decline in hematocrit. statistically significant elevation of erythrocyte number, hemoglobin concentration, and hematocrit was observed at 24 hr following the administ ...	1984	6714657
low triiodothyronine and raised reverse triiodothyronine levels in patients over fifty years of age who have type ii diabetes mellitus: influence of metabolic control, not age.	several studies have demonstrated that the uncontrolled diabetic state in both type i as well as type ii diabetes mellitus is characterized by altered thyroid hormone metabolism, which results in the lowering of serum triiodothyronine (t3) levels and a reciprocal elevation of t3 (rt3) levels. because the majority of type ii diabetics are over 50 years of age and because numerous previous reports have implicated aging as a cause of low t3 and high rt3 levels, we studied 220 type ii diabetics from ...	1984	6715765
circulating immunoglobulin e (ige) antibodies to l-thyroxine in a euthyroid patient with multinodular goiter and allergic rhinitis.	a 30-yr-old woman with allergic rhinitis and multinodular goiter developed atopic manifestations on different desiccated thyroid extract treatment. urticaria was observed when the patient was on l-t4 treatment; no atopy was experienced during l-t3 regimen. serum total immunoglobulin e (ige) concentration was 390 +/- 7ku/liter (mean +/- sd) prior to any treatment and rose to 850 +/- 7.5 ku/liter when the patient developed urticaria, but declined to baseline figures while she was on l-t3. intracut ...	1984	6715795
diminished lymphocytic cortisol metabolism-enhancing effect in endogenous thyrotoxicosis.	a study was carried out to determine the effect on lymphocytic cortisol metabolism (lcm) of plasma from 62 patients with diffuse thyrotoxic goitre (dtg), 14 patients with toxic nodular goitre (tng) and ten hypothyroid patients. plasma of 33 healthy donors served as controls. a known concentration of human lymphocytes was incubated with cortisol in media containing 50% phosphate-buffered saline (pbs) and 50% of one of the following additions: (1) pbs, (2) homologous plasma (hp), (3) heterologous ...	1984	6716032
the effect of propranolol and other antihypertensive drugs on preganglionic sympathetic activity in the cat.	preganglionic sympathetic nerve activity was recorded from the white rami of t3/t4 along with blood pressure, heart rate and femoral arterial conductance in vagotomised, atropinised cats under alpha-chloralose/pentobarbitone anaesthesia, and paralysed by gallamine. injection of propranolol or trimetaphan caused falls in mean blood pressure and concomitant rises in preganglionic sympathetic nerve activity. propranolol was then infused over 3 hr with a stepwise increase in dose rate. this infusion ...	1984	6717753
[therapy and follow-up of breast cancer. experiences in 11 years of observation].	out of 1260 biopsies performed on neoplasias of the breast in 11 years' surgical practice, 463 (36,7%) malignant tumours were encountered. the surgical strategy in the latter cases was based on two basic parameters: a) the histological report on the intraoperative biopsy; b) the clinical stage (tnm). after surgery oncological treatment followed the now universal standard practice: --t1, t2, t3, n+, m0 and t4 independent of n or m: multiple chemotherapy for 6-12 months then periodic check ups as ...	1984	6717827
[purification and characteristics of an rna-ligase preparation from bacteriophage t4].	a purification techniques was developed to obtain a preparation of the bacteriophage t4 rna-ligase (ec 6.5.1.3) free of contaminating nuclease activities. it includes fractioning on phosphocellulose and deae-cellulose, chromatography on deae-cellulose, isoelectric sedimentation, gel filtration through sephadex g-100 and chromatography on hydroxylapatite and aminohexyl-sepharose. the enzyme yield amounts to 30-37%. by means of biochemical tests, the preparation of rna-ligase was found to be good ...	1984	6718329
[thyroid function in the nephrotic syndrome].	serum total thyroxine (t4), triiodothyronine (t3), free thyroxine (ft4), free triiodothyronine (ft3) reverse triiodothyronine and t3 resin uptake (t3ru) as well as basal and post stimulating tsh were measured in twenty clinically euthyroid patients with the nephrotic syndrome. in comparison with control values, our patients showed (1) significantly lowered mean serum tbg levels (p less than 0,05) (2) unmodified mean serum t3, ft3 and rt3 values (3) significantly lowered mean serum t4 and ft4 lev ...	1984	6718837
[thyroid function after peritoneal lavage with polivinylpyrrolidone-iodine solution in diffuse peritonitis].	in 36 patients, intraoperative peritoneal lavage with pvp-iodine solution (26 patients) or with the iodine free chemotherapeutic agent taurolin (10 patients) was performed because of peritonitis. total iodine serum levels increased considerably after peritoneal lavage with pvp-iodine. in the early postoperative phase, the resorbed iodine was mostly present as iodide in serum. iodine serum values returned to normal after 30 days. a decrease in t4 and t3 could be observed with a concomitant recipr ...	1984	6720126
high efficiency of energy utilization in 'cafeteria'-and force-fed rats kept at 29 degrees.	male, sprague-dawley (charles-river) rats, of initial weight 272 g, were given a powdered stock diet (t1) ad lib., force-fed a synthetic diet (t2) or offered a range of palatable foods in conjunction with the powdered stock diet (t3) or a similar diet supplemented with certain minerals and vitamins (t4). metabolizable energy (me) intake (kj/d) averaged 303, 453, 402 and 383 for t1, t2, t3 and t4 respectively and corresponding weight gains were 5.5, 6.9, 8.2 and 7.9 g/d and were significantly dif ...	1984	6722082
[calorimetric study of bacteriophage t4 ghosts].	heat-induced structural transitions of bacteriophage t4 ghosts have been studied using differential scanning microcalorimetry and electron microscopy. the tail reorganization process is not an exothermic one. it is shown to correlate well with a heat absorption peak at maximum of 70 degrees c, but the sheath contraction and the hexagon -to-star base-plate transition themselves appear to proceed without any significant changes in enthalpy.	1984	6722190
lung function of children treated for malignant extrapulmonary tumors.	lung function was studied in 29 children suffering from extrapulmonary tumors of varying etiology (wilm's tumor, n = 7; bone malignancy, n = 17; nasopharyngeal epithelioma, n = 5). lung volume: vital capacity (vc) and functional residual capacity (frc), lung mechanics: lung resistance (rl), dynamic lung compliance (cldyn) and static lung compliance (clstat) and lung transfer factor for co (tlco), and blood gases were determined at different stages of therapy: at t0, before any aggressive treatme ...	1984	6722361
polyamines in breast cancer.	polyamine levels (putrescine, spermidine and spermine) in breast cancers (n = 54) were measured as a potential guide to prognosis. values (expressed as nmol per 100 mg tumour) ranged from: 0.9 to 4.5 for putrescine, 4.2 to 29.8 for spermidine and 5.6 to 39.7 for spermine concentration. increased intracellular polyamine levels were positively correlated with factors known adversely to affect survival after mastectomy, namely histological grade iii and oestrogen-receptor negative status. advanced ...	1984	6722462
effect of propylthiouracil on the thyroid tumorigenesis induced by n-bis(2-hydroxypropyl)nitrosamine in rats.	the effect of 0.15% propylthiouracil (ptu) on thyroid tumorigenesis was studied in male wistar rats given a single i.p. injection of 280 mg of n-bis(-2-hydroxypropyl)nitrosamine (dhpn) per 100 g body weight. the mean weights of the thyroid of rats treated with dhpn followed by ptu and with ptu alone were significantly higher than those of rats treated with dhpn only and control rats. the incidences of follicular adenoma at the end of week 20 of the experiment were 100% (21/21) in rats treated wi ...	1984	6722982
free thyroxin index and direct measurements of free thyroxin compared for evaluating postpartum autoimmune thyroid dysfunction.	measurement of free thyroxin (ft4) by a recently introduced commercial assay (amerlex free t4 ria) was compared with the calculated free thyroxin index (ft4i) for serum from 104 postpartum women. of these, 63 had transient thyroid dysfunction due to autoimmune thyroiditis, six had transient graves' thyrotoxicosis, and 35 were euthyroid with no signs of autoimmune thyroid disease. the correlation between results for ft4 and the calculated fti for 95 serum samples from women with no signs of autoi ...	1984	6723049
endemic infantile hypothyroidism in a severe endemic goitre area of central africa.	thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of ubangi, northern zaire. serum t4 was at the lower limit of normal at birth (104 +/- 4 nmol/l) and stayed at that level during the first year of life (123 +/- 9) (ns), but decreased to 75 +/- 8 (p less than 0.001) at 2-4 years and to 62 +/- 6 (p less than 0.001) at 5-7 ...	1984	6723080
successful treatment of thyrotoxic crisis with plasma exchange.	a 36-yr-old woman with thyroid storm was successfully treated with plasma exchange. after the first plasma exchange, free serum thyroxine (t4) was decreased and serum thyroxine-binding globulin (tbg) was significantly increased. the decrease in the patient's free t4 level after plasma exchange can perhaps be attributed to t4's increased binding capacity. plasma exchange may be an effective therapy for thyrotoxic crisis and should be performed immediately if conventional therapy fails to improve ...	1984	6723341
a study of cardiac effects of thyroid hormones: evidence for amelioration of the effects of thyroxine by sodium ipodate.	we studied the effects of daily ip administration of t4 (200 micrograms/100 g bw) or t3 (50 micrograms/100 g) to the rat (six per group) for 3 days with or without sodium ipodate (6 mg/100 g), propylthiouracil (ptu; 2 mg/100 g), propranolol (0.5 mg/100 g), or amiodarone (2.5 mg/100 g) on cardiac weight, 3',5'-diiodothyronine (3',5'-t2) to 3'-monoiodothyronine monodeiodinating activity (ma), mitochondrial alpha-glycerophosphate dehydrogenase (alpha gpd), and/or cytosolic ornithine decarboxylase ( ...	1984	6723573
thyroid hormone metabolism and the source of plasma triiodothyronine in 2-week-old rats: effects of thyroid status.	earlier studies have shown larger increments in serum t3 in 2-week-old congenitally hypothyroid rats than in euthyroid controls after injections of small doses of t4. since hepatic and renal 5'-deiodination of t4 to t3 in vitro (5' d-i) is reduced during the neonatal period and in hypothyroidism, those results suggest that there may be major changes in the distribution and metabolism of t3 or that an alternative enzymatic pathway is the predominant source of extrathyroidally produced t3 in these ...	1984	6723586
localization of the cells of origin for primary afferent fibers supplying the gallbladder of the cat.	horseradish peroxidase was utilized to study the distribution of afferent fibers from the gallbladder in cats. the afferent cell bodies were found in the nodose ganglion and t4 to l1 dorsal root ganglia.	1984	6723891
[free thyroxine estimation for screening of hyper- and hypothyroidism in an adult population].	serum free thyroxine (ft4) was determined in 1,114 adults (male 239, female 875) in a periodic health evaluation in 1980 to detect unsuspected thyroid dysfunction, especially hyper- and hypothyroidism. the participants were dwelling in two towns of miyagi prefecture. beside ft4, serum t4 and t3 were also determined by radioimmunoassay. if thyroid dysfunction was suspected, further detailed examinations such as trh-test (500 micrograms i.v.), radioimmunologic determinations of serum tsh and tbg, ...	1984	6724056
thyroid function and prolactin levels in insulin-dependent diabetic children and adolescents.	we evaluated serum thyroid hormones, tsh, and prolactin before and after induction of trh and thyroid microsomal autoantibodies in 91 diabetic children and adolescents (mean age 11.11 +/- 4.13 yr), with illness ranging from a few days to 14.25 yr, and in 127 "short-normal" subjects (mean age 10.32 +/- 3.18 yr). all were clinically euthyroid. the control pubertal subjects showed t4, rt3, tbg, and rt3/t3 ratio values that were significantly lower than those of prepubertal subjects. the prl area wa ...	1984	6724148