Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| suckling ability and maternal prolactin levels in hypothyroid rats. | long-evans rats and their offspring were made hypothyroid by addition of the antithyroid goitrogen 6-n-propylthiouracil (ptu) to the drinking water (0.1%) from the day of parturition. serum concentrations of prolactin (prl), thyroid-stimulating hormone (tsh) and thyroxine (t4) were determined by double radioimmunoassay (ria). from the fifth postnatal day, body weight of ptu-treated pups was significantly lower than that of control rats, and a strikingly elevated serum tsh level and nondetectable ... | 1984 | 6519658 |
| the effect of endotoxin and radio-detoxified endotoxin on the serum t4 level of rats and response of their thyroid gland to exogenous tsh. | we have demonstrated that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum t4 level of rats and inhibits the t4 response given to exogenous thyroid stimulating hormone (tsh), the radio-detoxified (60co-gamma, 150 kgy) endotoxin preparation does not inhibit the response to exogenous tsh and decreases serum t4 level to a lesser extent than untreated endotoxin. | 1984 | 6519960 |
| [thyroid hormone changes (iodothyroninemia) in patients with acute myocardial infarction, and their clinical significance]. | the data are reported on the pattern of the t3/t4 ratio in patients with acute myocardial infarction throughout the hospitalization period. different forms of dysthyreosis were identified related to the period of the disease and its clinical outcome. the first days of the disease were characterized by low levels of t3 and an increase in the content of total t4. further transformation of the dysthyreosis depended on the outcome of myocardial infarction at the hospitalization stage. in myocardial ... | 1984 | 6521188 |
| [mesopharynx cancers--multifactorial malignancy analysis and therapeutic results]. | multi-step check method of the diagnosis of malignancy is applied as a synthesis of results of staging, histological classification, histopathological and histochemical grading, to 210 squamous cell carcinomas of the mesopharynx. among the examined carcinomas, extended tumours were predominant (61%) (t3; t4). no definite relationship between size and prognosis of the tumours was seen. 81% of the carcinomas had regional lymph node metastases. their rate of cure (41%) was lower than that of the ca ... | 1984 | 6521586 |
| [thyroxine hyperthyroidism (t4-toxicosis)]. | 1984 | 6522314 | |
| [thoracic pain and arteriovenous fistula of the spinal cord]. | a 58 year old man was admitted with a pseudo-coronary pain. cardiological investigations (ecg, chest x-ray, enzymes) were normal. pain however was exacerbated by movement, coughing and pressure over t4 to t10 vertebrae. on the 4th day, the patient developed a weakness of the right lower limb which worsened 15 days later. on examination there were in the right lower limb a combination of central (babinski sign) and peripheral signs (diminished deep reflexes, loss of sensation to all modalities ip ... | 1984 | 6522915 |
| circadian time structure of endocrine and biochemical parameters in adult onset (type ii) diabetic patients. | forty-one endocrine and biochemical serum parameters were studied over a 24-hour span with 6 samples at 4-hour intervals in 20 non-insulin dependent (type ii) diabetics and in 20 non-diabetic subjects matched for sex, age, height and weight. circadian rhythms were verified by cosinor analysis. group-synchronized circadian rhythms were detected in diabetic and non-diabetic subjects with no statistically significant difference in any of the rhythm parameters (rhythm adjusted mean, amplitude and ac ... | 1984 | 6523019 |
| [antiarrhythmic effect and side effects of amiodarone]. | amiodarone (am) is one of the most potent antiarrhythmic drugs, the value of which is limited by reversible and irreversible side-effects (se). 59 patients, 50 male, 9 female (age 33 to 81 years) entered the study with ventricular tachycardia (vt, 68%), wpw-tachycardia (12%), non-sustained vt (12%) or untreatable paroxysmal atrial fibrillation or supraventricular tachycardia (8%). prior to am the patients had received 1 to 8 different antiarrhythmic drugs (m 3.5) and maximal 9 different combinat ... | 1984 | 6523885 |
| [endocurie therapy of breast cancer i. indication and value of the implantation of iridium 192 within the total concept of conservative organ-preserving therapy of breast cancer]. | the goal of conservative surgery is reduction of macroscopic tumour masses and lymph node sampling. in combination with adequate radiotherapy the local control rates reported by some authors are as good as those of radical surgery. interstitial implantation of ir192 offers the possibility of applying very high radiation doses without early complications and late effects. this method could also be carried out effectively as primary treatment, even for locally advanced stages. the recurrence rates ... | 1984 | 6523886 |
| [intracellular neutralization of bacteriophage t4 by antiphagic serum]. | specific antiserum, introduced into the spheroplasts of escherichia coli b infected with bacteriophage t4, has been shown to neutralize phage particles formed within the cells. | 1984 | 6524168 |
| [preparation of 125i-labelled tetraiodothyroxine, t4, for the analysis of total serum t4 (ria)]. | 1984 | 6524448 | |
| thyroid hormone levels in diabetic mothers and their neonates. | infants born to diabetic mothers have decreased activity of many metabolic pathways which might be regulated by thyroid hormone. serum tsh, t4, t3, and reverse t3 levels were measured in 22 term infants of diabetic mothers and in 9 normal term babies at 2, 12, 24, and 72 hours of age, as well as in maternal and cord sera. t4 binding index and free t4 levels were measured in 11 diabetic mothers and their babies and 5 normal mothers and babies. mean tsh levels did not differ between diabetic and n ... | 1984 | 6525214 |
| correlations of event-related potentials with schizophrenic deficits in information processing and hemispheric dysfunction. | in order to obtain further insight into hemispheric dysfunction in schizophrenics, two experiments were conducted employing event-related potential (erp) recording during dichotic detection tasks as well as syllable discrimination tasks. results concerning erps derived from the t3 and t4 regions are reported. based on results in the two experiments, it is concluded that schizophrenics display a dysfunction of the left hemisphere, as well as a dysfunction in the ingration mechanism of both hemisp ... | 1984 | 6525386 |
| molecular-mechanical studies of hormone-protein interactions: the interaction of t4 and t3 with prealbumin. | 1984 | 6525407 | |
| precocious synthesis of oestrogen-induced vitellogenin by embryos pre-treated with thyroid hormones. | treatment of 9-day-old chicken embryos with oestrogen results in only barely detectable amounts of induced vitellogenin being present in their sera after 13 days of incubation. readily detectable amounts of vitellogenin are normally first seen in sera at 16 days of incubation (oestrogen having been administered at 12 days of incubation). however, pre-treatment of such embryos (those above) with thyroxine (t4) at 6-8 days of incubation results in substantial amounts of vitellogenin being present ... | 1984 | 6525882 |
| post-vagotomy changes in the ultrastructure of the thyroid gland and circulating levels of its hormones in the pigeon. | pigeons subjected to bilateral cervical vagotomy, were investigated for changes in the ultrastructure of the thyroid and circulating levels of the thyroid hormones, t4 and t3. vagotomy caused pronounced activation of the thyroid follicular cells which was characterized by considerable enlargement of the cells, increase in colloid droplets, mitochondria, lysosomes and microvilli, and a well developed golgi complex. as for the blood levels of t4 and t3, there was significant decrease in t4, but an ... | 1984 | 6525885 |
| [model of the 3-dimensional structure for the c-portion of the long fibrils of bacteriophage t4]. | 1984 | 6525959 | |
| radiation therapy of carcinoma in the rectum and sigmoid colon. | radiation therapy combined with some anti-cancer drugs was performed in a total of 79 patients with carcinoma of the rectum and sigmoid colon, consisting of 41 primary, 25 recurrent and 13 postoperatively irradiated ones. relief of subjective symptoms was observed in 50% or more of primary and recurrent patients. radiation response of tumor was marked in 23 (56%) of primary ones. five-year survival rate was 21% in the primary patients without any remote metastasis, 11% in the recurrent and 27% i ... | 1984 | 6528337 |
| enhanced prolactin secretion in patients with primary hypothyroidism during thyroid replacement. | thyroid hormones are known to exert some influence on prolactin (prl) secretion indirectly via the hypothalamic dopaminergic system and directly at the level of pituitary gland. in order to study the effect of thyroid hormones on the activity of hypothalamic dopamine neurons, lactotrophs and thyrotrophs, we administered increasing doses of thyroid hormones to patients with primary hypothyroidism, and examined the changes of basal prl, tsh and prl responses to a dopamine receptor blocker (sulpiri ... | 1984 | 6528338 |
| stages i and ii non-hodgkin's lymphomas of waldeyer's ring and the neck. | in a previous communication we reported our results for patients with localized extranodal presentations of non-hodgkin's lymphomas of the head and neck who were admitted between 1961-1969. this review describes our larger experience from 1947-1982 in treating 137 stages i and ii waldeyer's ring patients whose slides were available for reclassification according to the modified rappaport system. all of these patients were treated definitively as follows: radiotherapy only, 113 patients; radiothe ... | 1984 | 6528861 |
| direct determination of uracil in [32p,uracil-3h]poly(da.dt) and bisulfite-treated phage pm2 dna. | a simple but effective technique for determining the presence of uracil existing as either a:u base pairs or g:u base pairs in dna was developed. dna is degraded to deoxynucleoside 3'-monophosphates by a combination of micrococcal nuclease and spleen phosphodiesterase. the monophosphates are converted to 5'-end-labeled 32p-labeled diphosphates in a reaction catalyzed by t4 polynucleotide kinase. the resultant product is then converted to 5'-end-labeled deoxynucleoside monophosphates by p1 nuclea ... | 1984 | 6528982 |
| effect of a second dose of thyrotropin on exocytosis and endocytosis in the rat thyroid gland. | the effect of tsh on exocytosis and endocytosis in thyroid follicle cells was studied with electron microscopic stereology. groups of rats, pretreated with t4 for 2 d, were injected iv with tsh (500 mu) 20 min, 2, 4, 6, and 8 h before perfusion fixation. parallel groups were given a second dose of tsh 2, 4, 6 and 8 h after the first one and the thyroids were fixed after 20 min. in controls, injected with saline, the membrane surface area (msa) of exocytotic vesicles was about the same as that of ... | 1984 | 6530513 |
| multiple sclerosis co-existent with myxedema. an autopsy case report. | a 64-year-old woman developed impaired consciousness and vision, sensorimotor paresis, hypothermia, bradycardia, and edema. symptoms fluctuated with seasonal exacerbations in winter and terminated in coma with respiratory insufficiency at age 69. high csf protein content and low serum t4 and tsh levels were noted. treatment with prednisolone and thyroxin considerably improved her consciousness and edema. the patient suddenly expired of pulmonary embolism. postmortem examination revealed a marked ... | 1984 | 6530612 |
| effects of xylazine immobilization on biochemical and endocrine values in white-tailed deer. | the effect of xylazine hydrochloride on biochemical and endocrine parameters in plasma was examined in adult white-tailed deer (odocoileus virginianus (zimmermann]. in the first experiment, seven animals were injected intramuscularly via a blowgun dart with 0.65 mg/kg xylazine (100 mg/ml) and were bled 10, 20, 30, and 60 min post-injection. in the second experiment, eight animals were manually restrained for the first blood sampling and then injected manually and bled as before. plasma calcium ( ... | 1984 | 6530719 |
| a case of hypokalemic myopathy associated with transient hypothyroidism. | a case of transient hypothyroidism in the course of hypokalemic myopathy is reported. a 69-year-old woman had severe muscle weakness and marked potassium deficiency associated with alkalosis during treatment with thiazide diuretics. the cause of muscle weakness proved to be hypokalemic myopathy confirmed by clinical findings and muscle biopsy. after the episode of hypokalemic myopathy, serum levels of thyroid hormone were lowered (t4; 3.8 micrograms/dl, t3; 54 ng/dl) and that of tsh was elevated ... | 1984 | 6532797 |
| thyroid antibodies in healthy blood donors. | the frequency of thyroid antibodies was investigated in 1314 healthy blood donors. twenty-three of 870 males (2.6%) were positive for thyroglobulin antibody (ta), 34 (3.9%) for thyroid microsomal antibody (ma) and 19 (2.2%) for both ta and ma. thirty-four of 484 females (6.2%) were positive for ta, 46 (9.5%) for ma and 29 (6.0%) for both ta and ma. eighty-six of 1314 blood donors were positive for ta and/or ma. there was no difference in liver function tests between aat and controls. in females, ... | 1984 | 6532799 |
| [prevention of hyaline membrane disease by intraamniotic administration of thyroxine]. | the best management of respiratory distress syndrome (rds) is prevention. prenatal administration of cortico-steroids has been proved to be a valuable way for accelerating fetal lung maturation. in case of high risk pregnancy, however, where acceleration of lung maturation is most needed, there may be a relative contraindication for using steroids. according to the theory that the increase in the phospholipid component of surfactant may be mediated by intra-amniotic thyroxin administration, its ... | 1984 | 6533584 |
| [results and indications of radiotherapy in the treatment of carcinoma of the mouth floor]. | 175 carcinomas of the floor of the mouth were treated by radiotherapy in the years 1971-81: 47 t1 (26.9%) 87 t2 (49.7%) 19 t3 (10.8%) 22 t4 (12.6%). according to local extension the primary was treated by curietherapy in 92 patients (52.6%), external radiotherapy plus curietherapy boost in 8 (4.6%), radiosurgical combinations in 25 (14.3%) and external radiotherapy alone in 50 (28.5%). 131 patients were initially n0 (74.9%) 23 n1 (13.1%) 21 n2-3 (12.0%). the treatment on the nodal areas was: wai ... | 1984 | 6535172 |
| does the consensus mean represent a suitable reference value in t3, t4, tsh interlaboratory surveys? | 1984 | 6535836 | |
| [automated recording of precision profiles for the radioimmunological determination of t4 using a pocket calculator of the hp-41 cv type]. | precision profiles as useful tool for assurance of assay quality in 10 independent t4rias have been automatically obtained using a small programmable pocket calculator hp-41 cv. for each t4 assay batch, the within-assay coefficient of variation varied from 7 to 11% in the hormone concentration range of 2 to 20 micrograms/dl. the difference in coefficient of variation for all the 10 successive assay batches of t4, never exceeded 1% in the same hormone concentrations regions. all the above finding ... | 1984 | 6536211 |
| [cancer of the nasopharynx in morocco: epidemiological approach]. | between 1 april 1980 and 30 septembre 1983, 412 cases of nasopharyngeal carcinoma were seen at the bergonié cancer centre in casablanca (the sole centre in the country), representing 4.76% of all malignant tumours diagnosed in that period. this percentage is low, since the majority of these tumours are not diagnosed outside the big towns but indicates that morocco is an area of moderate incidence for this cancer. we have studied the epidemiological aspects of our series; there is a predominance ... | 1984 | 6536623 |
| plasmapheresis versus lymphoplasmapheresis in rheumatoid arthritis: immunologic comparisons and literature review. | eight patients with functional class iii, seropositive, erosive rheumatoid arthritis unresponsive to remittive drugs each underwent nine aphereses over 3 weeks. four had a 40-ml/kg plasma exchange and four others had a 40-ml/kg plasma exchange plus a mean 5.67 x 10(9) lymphocyte depletion. both groups appeared to improve clinically. t and b cell counts and ok t4 and ok t8 ratios decreased in the lymphoplasmapheresis group. phytohemagglutinin stimulation decreased in lymphoplasmapheresis and incr ... | 1984 | 6536669 |
| [musculocutaneous flaps in cervicofacial oncology surgery. experience in 145 cases]. | the use of myocutaneous flaps in reconstructive surgery after cancer resection for t3-t4 tumors of the head and neck is reported in 145 clinical cases. in this series, flap viability, proved to be as high as 96%. the use of myocutaneous flaps extends far beyond the limits of tumor resection, improves functional and cosmetic results and permits to operate safely on irradiated patients. this study shows that healing in irradiated patients tends to be comparable to that in non irradiated patients. ... | 1984 | 6537710 |
| thyroid-testis interrelationship during the development and sexual maturity of the rat. | the effects of thyroidectomy and treatment with thyroxine (t4) were studied in immature male rats to evaluate the role of the thyroid in the development of testicular functions. thyroidectomy inhibited gametogenesis and development of the leydig cell in these rats. however, the effects could be reversed by administration of 10 micrograms t4 (i.p.) daily for 30 days. | 1984 | 6537747 |
| dna binding protein from ovaries of the frog, xenopus laevis which promotes concatenation of linear dna. | a soluble extract of xenopus laevis ovaries catalyzed atp-dependent concatenation of linear duplex dna molecules. dna ligase and a unique x. laevis dna binding protein were required for the formation of concatemers. a linear dna concatenation system was reconstituted using t4 dna ligase and homogeneous x. laevis dna binding protein. this system catalyzed intermolecular ligation of dna molecules into linear concatemers of up to ten or more times monomer length. | 1984 | 6537981 |
| intravenous cis-platinum for invasive bladder cancer. safety and feasibility of a new approach. | the five-year survival rate of patients with locally invasive bladder cancer (stages t3-t4, nx, mo) is less than 50% whatever treatment is given. in an effort to improve the prognosis of patients with this disease, we have incorporated into a management protocol two cycles of intravenous administration of cis-platinum before surgery or radiotherapy (which function as the "definitive" treatment). in 10 of the first 12 patients treated, tumour necrosis has been demonstrated histologically, and def ... | 1984 | 6538255 |
| hormonal changes in normal men under marginally negative energy balance. | six men were confined to a metabolic unit for 105 days. their assigned work and energy intake were varied throughout six metabolic periods in order to create either a marginally negative (-15%) or an equilibrated energy balance. they were fed a defined diet providing a constant amount of protein. at each metabolic period, t4, t3, reverse t3(rt3), free t3, free reverse t3, thyroid-stimulating hormone, cortisol, cortisol-binding globulin, testosterone, and testosterone/estradiol-binding globulin w ... | 1984 | 6539064 |
| behavioral testing of progenies of tx (hypothyroid) and growth hormone-treated tx rats: an animal model for mental retardation. | virgin sprague-dawley holtzman rats were rendered tx (hypothyroid) by radiothyroidectomy and maintained on 1.0 microgram t4 (thyroxine) per 100 g bw until pregnant. one-half of these tx animals were administered 0.5 iu of growth hormone (gh) during the last 10-11 days of gestation as gh secretion is especially deficient in tx rats. untreated, food restricted to the level consumed by the tx-only rats, gh-treated euthyroid, and t4-treated until pregnant animals served as controls. the animals were ... | 1984 | 6539858 |
| lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects. | we studied the effects of lymphocytapheresis in five patients with chronic progressive ms. ten lymphocytapheresis treatments were given in 2 weeks, followed by 1 treatment every 2 weeks for 2 to 6 months. four of five patients had a fall in the circulating lymphocyte count during the initial treatment, and in three patients a modest lymphopenia was sustained with maintenance therapy. in patients with abnormal t4:t8 ratios, no improvement in the t4:t8 ratio occurred. there was no apparent clinica ... | 1984 | 6539868 |
| postnatal development of kidney function in rats receiving thyroid hormones. | in immature rats, renal excretion of p-aminohippurate (pah) can be increased by daily pretreatment with triiodothyronine (t3) or tetraiodothyronine (t4) beginning on the 2nd day after birth (10 micrograms/100 g b.wt. i.p.). the increase of pah excretion is nearly of the same extent, if 5-, 10-, 20-, 30-, 50-, and 105-day-old rats were pretreated with thyroid hormones (10 micrograms/100 g b.wt. i.p., 3 days, once daily). there is no strongly dose dependent renal effect of t3 and t4, respectively. ... | 1984 | 6540694 |
| serum t4, t3, r-t3, tsh and tg levels in cord blood and maternal circulation at the time of delivery. | the concentrations of t4, t3, r-t3, tsh and tg were determined in parallel in maternal serum at the time of delivery and in cord blood. the serum t3 concentration in cord blood was significantly lower than that in the serum of the mother. however contrary to t3, r-t3 in cord serum was significantly higher than in maternal serum. also, the level of tsh in cord blood was considerably higher than in maternal serum. the concentrations of total t4 in maternal and cord serum did not differ markedly, e ... | 1984 | 6540696 |
| photochemical cross-linking of the escherichia coli single-stranded dna-binding protein to oligodeoxynucleotides. identification of phenylalanine 60 as the site of cross-linking. | the single-stranded dna-binding proteins from bacteriophage t4, f plasmid, escherichia coli, and calf thymus can all be covalently cross-linked in vitro to thymine oligonucleotides by irradiating the respective protein-oligonucleotide complexes with ultraviolet light. more extensive studies on the e. coli single-stranded dna-binding protein (ssb) indicate that this reaction is dependent upon both the length of the oligonucleotide and the dose of ultraviolet irradiation. using anion-exchange and ... | 1984 | 6540775 |
| the effect of d- and l-thyroxine on sex hormone-binding globulin in rabbits. | serum sex hormone-binding globulin (shbg) concentration is increased in patients with thyrotoxicosis. shbg is also present in rabbit serum, although it does not bind estradiol-17 beta (e2). studies were carried out in female rabbits to determine the effects of thyroid hormone on shbg. serum concentrations of l-t4 cholesterol, e2, progesterone, free and total testosterone (t), and shbg were measured in immature female rabbits (8-10 weeks of age). rabbits were ovariectomized or subjected to sham s ... | 1984 | 6541121 |
| depletion and reaccumulation of follicular thyroglobulin (tg) in guinea-pig thyroid gland after short- and long-term administration of thyrotropin (tsh). | the relationships among the content and composition of soluble iodoproteins in thyroid gland, the serum tg concentration and the morphological structure of gland were investigated in guinea-pigs during short-term and long-term tsh administration (2 i.u. per day for 1 to 28 days). a significant decrease in the content of tg in the gland (from 6.50 mg to 1.32 mg/100 mg tissue), disappearance of 12 s iodoprotein, hypertrophy and hyperplasia of the follicular cells were observed in guinea-pigs treat ... | 1984 | 6541146 |
| effect of d-thyroxine on serum sex hormone binding globulin (shbg), testosterone, and pituitary-thyroid function in euthyroid subjects. | concentrations of serum sex hormone binding globulin (shbg) and free testosterone (t) were examined in 10 euthyroid subjects (5 men and 5 women) before, during and after 30 days of the daily ingestion of 1 or 4 mg d-thyroxine (d-t4), the thyroxine analog that has only 1-15% of the calorigenic effect of l-thyroxine (l-t4). no changes in serum l-t4 or triiodothyronine (t3), serum cholesterol, shbg, t, progesterone, estradiol-17 beta, or free t concentrations were observed in response to the 1 mg d ... | 1984 | 6542576 |
| studies on rna ligase activity in the brain and liver cells of mouse. | rna ligase in eukaryotic mammalian cells was studied by using mouse brain and liver cell extracts as enzyme sources and oligo a as substrates. rna ligase activity was determined by measuring the formation of alkaline phosphate-resistant product from 5'-32p-terminated oligoribonucleotides. under appropriate conditions, the activity of this enzyme in brain and liver cells may vary between 16-49 mu/ml. the joining way between donor and acceptor is 5'-p----3'-oh. further studies were carried out by ... | 1984 | 6543994 |
| the thyroid-system function in preterm infants of postmenstrual ages of 31 weeks or less: evidence for a "transient lazy thyroid system". | a prospective study was conducted in order to evaluate thyroid function in 20 healthy and 18 sick preterm infants with postmenstrual ages of 31 weeks or less. the clinical condition of both groups was compared using a "neonatal special care evolution score". the effect of thyroid hormone treatment, given from d10 on to the sick infants, was also studied. tsh, thyroid hormone levels (tg, t4, t3, rt3, ft4 and ft3) and tbg were measured by radioimmunoassays at d0, d10, d20, d30 and d40. healthy pre ... | 1984 | 6544306 |
| stimulation of snell dwarf mouse neuronal growth by gh and t4. | an investigation of the snell dwarf motor cortex, area 6 of caviness, was carried out by means of a modified golgi silver impregnation method. the pyramidal neurons located in layer v were found to have small perikarya, short primary dendrites with sparse branchings. following administration of bovine growth hormone (bgh) and thyroxine (t4) during the first 20 d of postnatal life, this retarded neuronal growth was restored to normal: neuronal perikarya were enlarged, and the dentrites were thick ... | 1984 | 6544386 |
| cis-diamminedichloroplatinum (ddp) as initial treatment of invasive bladder cancer. | cis-diamminedichloroplatinum (ddp) was used as the initial treatment in a pilot study of 17 patients with biopsy-proven transitional cell carcinoma of the bladder. no patient had received any previous radiotherapy or chemotherapy. the clinical stages of the tumours were t2 (2 patients), t3 (13) and t4 (2). before treatment the tumours were assessed by cystoscopy, biopsy, examination under anaesthesia (eua), computed axial tomography (ct scan) and ultrasound. ddp was given at a dose of 100 mg/m2 ... | 1984 | 6544614 |
| influence of the pineal gland and circadian rhythms in circulating levels of thyroid hormones of male hamsters. | thyroxin (t4) and triiodothyronine (t3) were measured by radioimmunoassay in serum of hamsters sacrificed at 4-hr intervals throughout the daily light-dark cycle (14l/10d). both t4 and t3 concentrations increased significantly during the l period of the daily cycle and decreased during the d period of the cycle; a.m. versus p.m. differences in free thyroxin indices (fti) were also studied using the t4 and t3 uptake assays of nuclear medical laboratories (dallas, texas). the free thyroxin index w ... | 1984 | 6545802 |
| decrease of peripheral large granular lymphocytes in graves' disease. | peripheral large granular lymphocytes (lgl) were enumerated in normal subjects and patients with autoimmune thyroid diseases. in normal subjects, the percentage of lgl was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; p less than 0.05) than in men (19.5 +/- 5.3%; n = 20). in untreated patients with thyrotoxic graves' disease (gd), both the percentage (11.5 +/- 2.7%; n = 12; p less than 0.001) and the absolute count (244 +/- 102/mm3; p less than 0.01) of lgl were significant ... | 1984 | 6546360 |
| ratio of serum triiodothyronine to thyroxine and the prognosis of triiodothyronine-predominant graves' disease. | triiodothyronine (t3)-predominant graves' disease is characterized by persistently high serum t3 level, normal serum thyroxine (t4) level, and high (greater than 20) serum t3/t4 ratio (nanograms/micrograms) during thionamide drug therapy. we studied the clinical course of 30 patients with t3-predominant graves' disease. after receiving drug therapy for 1 to 4 years, 27 patients with t3-predominant graves' disease had relapses, whereas only 9 control patients with graves' disease whose serum t3/t ... | 1984 | 6546484 |
| evaluation of free thyroxine methods in the presence of iodothyronine-binding autoantibodies. | circulating iodothyronine-binding autoantibodies interfere with total t4 and t3 rias, giving falsely high or falsely low values depending on the assay separation method used. direct serum free t4 (ft4) measurement should compensate for such abnormal binding if the method is free of artefact. we assessed 5 different ft4 methods in 12 patients with immunoglobulin binding of iodothyronines, with limited assessment of a sixth method in 2 subjects. thyroid status was assessed clinically and by measur ... | 1984 | 6546576 |
| [place of nuclear medicine methods in thyroid diagnosis]. | since the introduction of precise and easily accessible methods of measuring the level of t4 and t3 in serum, the use of isotopes to assess thyroid function can no longer be advocated. moreover, the recent growth in knowledge concerning the pathogenesis of thyroid diseases indicates that not even scintigraphic imaging of the thyroid gland contributes substantially to therapeutic decisions in routine situations such as graves' disease and most euthyroid and hyperthyroid nodular goiters. the use o ... | 1984 | 6546807 |
| characterization of immature sinus histiocytes (monocytoid cells) in reactive lymph nodes by use of monoclonal antibodies. | the distinctive mononuclear cells that appear in the cortical sinuses of lymph nodes in toxoplasma lymphadenitis and other conditions have been termed "immature sinus histiocytes," although these cells have neither enzyme histochemical nor ultrastructural features of histiocytes. the authors stained these cells in frozen sections of six reactive lymph nodes, using the immunoperoxidase technique, with monoclonal antibodies to t cell, b cell, and monocyte antigens and with heteroantisera to immuno ... | 1984 | 6546924 |
| short and long term effects of radioiodine treatment on the iodine content of the thyroid gland. | thyroid iodine content (tic) was measured in nine patients with hyperthyroid graves' disease for 5-26 months after treatment with 131i (100-125 muci/g tissue). in all patients, tic decreased; in eight patients it became undetectable within 5 +/- 3 (sd) months. this fall was parallel to those of serum t3 and t4 levels and was not prevented by the administration of large doses of stable iodine. in four patients, this decrease was irreversible and they became clinically hypothyroid. in the five oth ... | 1984 | 6548226 |
| total serum thyroxine and triiodothyronine; a comparison between graves' disease and hyperthyroxinaemia due to thyroxine replacement. | serum concentrations of total thyroxine (t4) and total triiodothyronine (t3) were measured in a group of patients (n = 113) presenting with untreated hyperthyroidism due to graves' disease and in subjects receiving oral t4 replacement (n = 93) in whom the total t4 concentration was supraphysiological (greater than 150 nmol/l). the mean total t4 concentration in the hyperthyroid group was 226 nmol/l, sd 59, range 151-420, and the mean total t3 concentration was 6.8 nmol/l, sd 2.73, range 3.1-17.5 ... | 1984 | 6548596 |
| t4 suppression test involving 24-hour thyroidal 131i uptake in patients with graves' disease compared to the t3 suppression test. | a t4 suppression test involving 24-h thyroidal 131i uptake was carried out on patients with graves' disease during therapy with an antithyroid drug. thirty-three patients received propylthiouracil (ptu) for at least 1 year. each patient was given 75 micrograms l-t3 daily for 8 days in conjunction with ptu (50 mg/day) at the time of the experiment and then the 24-h thyroidal 131i uptake (post t3 uptake was measured). twenty-two patients had normal levels of serum t3 and t4-i before l-t3 administr ... | 1984 | 6548699 |
| transplantation of human hyperthyroid tissue to the nude mouse. an experimental model. | this study analyzes the outcome of human normal and hyperfunctioning thyroid tissue transplanted to the nude mouse. thyroid fragments from 7 patients with graves' disease were transplanted to nude mice (nu/nu). before surgery, the patients had been treated with propranolol and iodine; none had received antithyroid therapy. the transplants were removed on the 12th day following transplantation and were studied by light microscopy and autohistoradiography. at this time, all immunologic disorders f ... | 1984 | 6548875 |
| [diagnostic procedure in suspected functional disorders of the thyroid gland]. | in an attempt to derive diagnostic concepts for thyroid diseases we present pathophysiological models for the prevalent thyroid disorders. 'euthyroid goiter' is a disease mainly caused by iodine deficiency but an additional immunopathogenesis was recently proposed. the 'immunthyropathy' is the thyroid disease with orbitopathy and other extraglandular immunological manifestations. a complete model of the immunological phenomena which begin with a tolerance defect is given, and both the t-cell, an ... | 1984 | 6549036 |
| absence of day to day variation in lymphocyte subpopulations in healthy humans. | lymphocyte subpopulations were determined by indirect immunofluorescence using monoclonal antibodies t11, t4, t8 and b1 on three different days in a group of thirteen normal subjects. although there was considerable intersubject variation, the percentages of lymphocyte subpopulations as well as absolute numbers did not differ within the same subject over the three days tested, showing that lymphocyte subpopulation proportions and absolute numbers are stable characteristics of the healthy subject ... | 1984 | 6549250 |
| thyroid hormone effects on skin and hepatic epidermal growth factor concentrations in neonatal and adult mice. | tissue concentrations of mouse epidermal growth factor (skin, submandibular gland and liver) are compared in control and thyroxine-treated neonatal and adult animals. the results identify an early onset thyroid-induced augmentation of egf levels in neonatal skin with continuation of hormone responsiveness into adult life. hepatic egf levels are shown to be low and, unlike skin and submandibular gland, are not augmented by t4. the significance of hormonal modulation of nonsalivary growth factor c ... | 1984 | 6607072 |
| monoclonal antibody-defined t-cell phenotypes and phytohemagglutinin reactivity of e-rosette-forming circulating lymphocytes from untreated chronic myelocytic leukemia patients. | t-cell phenotypes, as defined by murine monoclonal antibodies, (okt3, okt4, okt8, okia1), and phytohemagglutinin (pha) reactivity, were evaluated in e-rosette forming cells (t-cells) from 10 untreated chronic myelocytic leukemia patients. the proportion of t4+ cells was lower in patients than in controls (41.6 versus 61.7%, p less than 0.02); whereas the proportion of t8+ cells was similar in patients and controls. the decrease in t4+ cells in cml resulted in a decrease in circulating t4+/t8+ ra ... | 1984 | 6607098 |
| t-lymphocyte subsets in human lymph nodes: relative increase of okt-8+ cells in neoplastic and reactive b-cell proliferation. | cell suspensions obtained from 54 human lymph nodes involved by different pathological conditions were characterized by conventional markers and by the okt-3, okt-4, okt-8, okia-1, and okm-1 monoclonal antibodies. in 18 cases of reactive lymphoid hyperplasia, the majority of lymph node cells were mature t lymphocytes (e-rfc = 56 +/- 9%; okt-3+ = 63 +/- 10%); among t-cell subsets, okt-4+ cells were 49 +/- 8% whereas okt-8+ cells were 21 +/- 8% (t4/t8 = 2.7 +/- 1.1). this distribution of t-cell ph ... | 1984 | 6607799 |
| mononuclear cell subsets in human renal disease. enumeration in tissue sections with monoclonal antibodies. | mononuclear inflammatory cells (mic) in renal biopsies from 37 patients with renal disease were studied by avidin--biotin--immunoperoxidase complex (abc) technique, utilizing monoclonal antibodies to cell surface antigens: t11 (total t), t4 (inducer/helper), t8 (suppressor/cytotoxic), b1 (b cells), m1 (monocytes), and leu-7 (natural killer, nk cells). renal mic consisted mostly of t cells and monocytes. t cells were a predominating cell type in the renal interstitium of all patients studied (64- ... | 1984 | 6607801 |
| rhythms of cell proliferation in the hindlimb epidermis of control and thyroxine-treated rana pipiens tadpoles. | labeling and mitotic index rhythms were studied in premetamorphic tadpoles under an ld 12:12 with the light phase beginning at 0800 hr. in a 72-hr experiment, control labeling and mitotic index curves showed a peak in the light and a peak in the dark with labeling index rhythms of 12.4, 17.7, and 23.6 hr and a 21.4-hr mitotic index rhythm. thyroxine (t4) treatment resulted in a marked elevation of labeling index by 24 hr and of mitotic index by 48 hr, obscured the control bimodal pattern of peak ... | 1984 | 6607861 |
| influence of dna binding on the formation and reactions of tryptophan and tyrosine radicals in peptides and proteins. | the rate constant of the one-electron oxidation of the tryptophan (trp) or tyrosine (tyr) residues by br- x 2 radical anions is strongly decreased when the peptides are bound to dna. oxidation by n x 3 is much less affected by binding. these results can be explained by electrostatic repulsion between the charged polyphosphate backbone and the br- x 2 radicals. once oxidized, the interacting aromatic residues react with the dna in a first order process with a rate constant of the order 10(3) s-1. ... | 1984 | 6607898 |
| plasmapheresis increases t4 lymphocytes in a patient with aids. | previously the authors demonstrated that most patients with aids have serum antilymphocyte antibodies. therefore, in an attempt to decrease these antibodies and at least transiently increase blood lymphocytes, they treated one aids patient with three courses of plasmapheresis. during or after each course, his t4 lymphocytes rose significantly but subsequently fell to baseline values within two weeks after therapy. the increase in t4 lymphocytes was associated with removal of patient plasma rathe ... | 1984 | 6608262 |
| structure-activity relation of thyroid hormone analogues and tissue epidermal growth factor concentrations in neonatal and adult mice. | we have shown a positive correlation between the epidermal growth factor concentration in neonatal mouse skin and prior treatment with thyroxine (t4) or triiodothyronine (t3). the results of the present study indicate similar activity of other levorotatory iodothyronine analogues and suggest the following scale of decreasing potency: t3, triiodothyroacetic acid, triiodothyropropionic acid, t4, reverse t3, and diiodothyronine. metabolically inactive analogues (reverse t3, diiodothyronine) have no ... | 1984 | 6608265 |
| effect of phenytoin and carbamazepine on subpopulations of mononuclear blood cells as defined by membrane antigens. | mononuclear cells from peripheral blood of healthy blood donors were incubated with phenytoin 20 micrograms/ml or carbamazepine 10 micrograms/ml for 30 min at 37 degrees c. in 4 out of 10 incubation experiments, the percentage of cells expressing the membrane antigen t3 was markedly reduced. however, the mean percentage of cells expressing the antigens t3, t4, t8 and hla-dr was not influenced significantly by incubation with the drugs. accordingly, the reduction of iga and igm serum concentratio ... | 1984 | 6608502 |
| the immune status of healthy centenarians. | the immune status of 17 healthy individuals 100-103 years of age (centenarians) was investigated. qualitative values for immunoglobulins igg, igm, iga, and ige were within normal ranges for subjects more than 60 years of age with the exception of elevated igm in one individual. cell marker studies employing a panel of 27 monoclonal antibodies delineating t and b lymphocytes, monocytes, natural killer cells, granulocytes, and functional and developmental subsets of each were performed to phenotyp ... | 1984 | 6608550 |
| the influence of common variables on t cell subset analysis by monoclonal antibodies. | normal values for t cell subsets as defined by the most commonly used monoclonal antibodies of the okt series were determined in a group of 142 unrelated normal individuals. in most age classes females had significantly greater portions of okt3 and okt4 antigen bearing lymphocytes and accordingly a higher t4/t8 index. the range of individual normal values within the control population was remarkably wide. intra-individual differences between the t subset composition remained rather constant over ... | 1984 | 6608554 |
| self-renewal and maturation of immature t-cell progenitors within pha-induced agar t-cell colonies. | t-cell colonies derived from peripheral blood mononuclear cells plated in agar with phytohemagglutinin (pha) contain about 5-7% e-, okt3-, okt6-, tdt-, sig- cells phenotypically similar to bone marrow precursors since they are also rfb1+, okt10+, hla-dr+, and pna+. these cells can generate secondary e+, okt3+ t-cell colonies when replated in the presence of both pha and a colony-promoting activity distinct from the t-cell growth factor, interleukin 2. these observations suggest that e-, okt3- ce ... | 1984 | 6608563 |
| specificity of translational regulation by two dna-binding proteins. | the gene v protein of the filamentous bacteriophages fl, fd and m13, and the gene 32 protein of bacteriophage t4 share the property of binding strongly and co-operatively to single-stranded nucleic acids, especially dna. moreover, both are capable of repressing the translation of specific mrnas (gene 32 protein its own, and gene v protein that of the filamentous phage gene ii), both in vivo and in vitro. if the mechanism of repression by either of these proteins were based solely on its ability ... | 1984 | 6608587 |
| acquisition of specific cytotoxic activity by human t4+ t lymphocytes in culture. | mature human t lymphocytes can be separated by monoclonal antibodies okt4 and okt8 according to their surface phenotypes into t4+t8- and t4-t8+ subsets. from short-term experiments using bulk cultures, the helper/inducer function has been assigned to the t4+t8- subset and the cytotoxic/suppressor function to the t4-t8+ subset. thus if t lymphocytes are separated after stimulation in a mixed lymphocyte reaction (mlr), the entire cytotoxic activity is found in the t4-t8+ fraction whereas the t4+t8 ... | 1984 | 6608693 |
| characterization of a human x mouse t cell hybridoma and identification of a clone secreting and binding interleukin-2. | human lymphocytes stimulated with phytohaemagglutinin (pha) were fused with an hgprt- murine lymphoma, bw5147, and a hybridoma bwfc93-1 was isolated and cloned in agarose. this human x mouse hybrid and nine clones derived from it were characterized by chromosome analysis, phenotypic and functional assays. karyotyping and isoenzyme studies showed the presence of five human chromosomes in bwfc93-1 with preferential retention of three chromosomes--6, x and 15--in the clones. membrane immunofluoresc ... | 1984 | 6609121 |
| interaction between mhc-encoded products and cloned t cells. ii. analyses of physiological requirements indicate two different pathways of stimulation by class i alloantigens. | the interaction between class i major histocompatibility complex (mhc) products and t cells was studied using h-2kb-specific alloreactive t-cell lines and clones obtained by repeated in vitro stimulation with allogeneic cells. induction of proliferation of these t cells appeared to involve two signals: the h-2kb alloantigen and interleukins. immunopurified liposome-inserted h-2kb, which stimulates specific secondary in vitro cytotoxic t lymphocyte (ctl) responses, could not replace cell-associat ... | 1984 | 6609123 |
| total lymphoid irradiation therapy in refractory rheumatoid arthritis. fifteen- to forty-month followup. | twelve patients with refractory rheumatoid arthritis were treated with total lymphoid irradiation (tli) to a total cumulative dose of 3,000 rads. post-tli morbidity/mortality included 8 patients with xerostomia, 4 with weight loss of greater than 10 kg, 3 with loss of 4 or more teeth, 3 with herpes zoster, 4 with bacterial infection that was fatal in 2, 3 with hypothyroidism, 1 with cutaneous vasculitis, and death from myocardial infarction in 1 patient and cardiorespiratory arrest in another. t ... | 1984 | 6609705 |
| binding of gene 32 protein from phage t4 and reca gene product from e. coli to fluorescent single-stranded polynucleotides. | 1984 | 6609846 | |
| corticosteroid effects on circulating lymphocyte subset levels in normal humans. | the effects of in vivo corticosteroid administration on levels of lymphocyte subsets in normal humans require further definition. using monoclonal antibodies, we carried out a double-blind, placebo-controlled study of oral and intravenous methylprednisolone in 10 normal volunteers. four hours after a 7-day oral course of 0.5 mg/kg/day, there was modest lymphopenia but no significant selective alteration in lymphocyte subsets. in contrast, 4 hr after a single intravenous injection of 1.0 mg/kg, t ... | 1984 | 6609933 |
| human t cell antigens involved in cytotoxicity against allogeneic or autologous chemically modified targets. association of the leu 2a/t8 antigen with effector-target cell binding and of the t3/leu 4 antigen with triggering. | monoclonal antibodies (mab) recognizing human t cell differentiation antigens were employed to analyze the role of these antigens on t cell-mediated cytotoxicity against autologous 2,4,6-trinitrophenyl (tnp)-modified targets. the okt3/anti-leu 4 and anti-leu 2a/okt8 mab inhibited t cell-mediated cytotoxicity against autologous or unrelated tnp-modified targets, in the absence of complement and at the effector cell level. these cytotoxic effector cells were t3+, t8+, t11+, t4-. to analyze the rol ... | 1984 | 6610558 |
| mononuclear-cell subsets in human idiopathic crescentic glomerulonephritis (icgn): analysis in tissue sections with monoclonal antibodies. | mononuclear inflammatory cells (mic) were analyzed in renal biopsies from 16 patients with icgn (7 with glomerular immune complex deposits, 3 with anti-gbm disease, and 6 without immune deposits) by the avidin-biotin-immunoperoxidase technique utilizing monoclonal antibodies to cell surface antigens: t11 (total t), t4 (inducer/helper t), t8 (suppressor/cytotoxic t), b1 (b cells), m1 (monocytes/granulocytes), and leu 7 [natural killer (nk) cells]. total mic were significantly increased in both gl ... | 1984 | 6610688 |
| cellular mechanism of dna-specific antibody synthesis by lymphocytes from systemic lupus erythematosus patients. | the cellular mechanism of anti-dna antibody synthesis in patients with systemic lupus erythematosus (sle) was studied by dna-specific solid-phase radioimmunoassay. anti-dna antibody synthesis in response to dna was t-dependent, and the experiments with reconstituted lymphocytes from identical twins discordant for sle showed that b cells and t cells from sle patients must cooperate to synthesize anti-dna antibody. anti-dna antibody synthesis by lymphocytes from patients with inactive sle was enha ... | 1984 | 6611160 |
| distinctive phorbol ester-induced morphological and surface antigen changes in mycosis fungoides, the sézary syndrome, and adult t-cell leukemia. | clinical and pathological studies of cutaneous t-cell lymphomas (ctcl) reveal variations in tumor cell morphology and surface membrane phenotype that are of diagnostic and prognostic importance. our study investigates blastic transformation and surface antigen change on ctcl cells in vitro under the influence of tumor-promoting phorbol ester (tpa) and phytohemagglutinin. both agents transformed tumor cells with cerebriform nuclei into blast cells within 5 days; however, sézary cells were somewha ... | 1984 | 6611200 |
| circannual rhythms of plasma growth hormone, thyrotropin and thyroid hormones in prepuberty. | to clarify the occurrence of circannual gh, tsh, t4 and t3 rhythms in prepuberty we have been studying, for a four year period, 150 healthy subjects, aged 6-10, by cross-sectional design. plasma samples were taken at 0800 h and all hormones were measured by ria. the occurrence of any circannual rhythm was statistically investigated by the cosinor method. a significant rhythm was validated (p = 0.02) only in tsh secretion, with annual crest time in december; gh, t4, t3 did not show a circannual r ... | 1984 | 6611225 |
| lymphocyte subsets and immune complexes in long-standing diabetic patients: relation with the presence of microangiopathy. | subsets of peripheral t lymphocytes by monoclonal antibodies and circulating immune complexes by two different methods were evaluated in 36 long-standing diabetic patients, 19 type 1 (insulin dependent) and 17 type 2 (non-insulin dependent). in all patients the presence of microangiopathy was assessed by retinal fluoroangiography, albuminuria and creatinine clearance. in patients with type 1 diabetes a significant decrease of total t and of t cells with helper phenotype (t4), together with an in ... | 1984 | 6611302 |
| t-lymphocyte subsets in liver tissues of patients with primary biliary cirrhosis (pbc), patients with primary sclerosing cholangitis (psc), and normal controls. | t lymphocytes infiltrating hepatic tissues were typed and enumerated in liver biopsies of patients with primary biliary cirrhosis (pbc), patients with primary sclerosing cholangitis (psc), and normal controls using monoclonal antibodies and the avidin-biotin-immunoperoxidase technique. the peripheral blood mononuclear cells were studied also by flow cytometry. in pbc, t lymphocytes were decreased (p less than 0.001) in the blood [absolute number was 426 +/- 200 (se) vs 1351 +/- 416 in 15 control ... | 1984 | 6611346 |
| characterization of the stimulatory effect of t4 gene 45 protein and the gene 44/62 protein complex on dna synthesis by t4 dna polymerase. | on a variety of single-stranded dna templates, the overall rate of in vitro dna synthesis catalyzed by the bacteriophage t4 dna polymerase is increased about fourfold by addition of the t4 gene 44/62 and 45 proteins. several different methods suggest that this stimulation reflects an increase in the average dna polymerase "sticking distance", or processivity, from 800 to about 3000 nucleotides per initiation event. both the 44/62 protein complex and the 45 protein must be present to obtain this ... | 1984 | 6611423 |
| transglottic carcinoma. | the cases of 152 patients with transglottic carcinoma were reviewed. there were 31% t2, 39% t3, and 30% t4 lesions. twenty-six percent of patients had neck node metastases at initial presentation, and 19% with no neck dissection or radical irradiation to the neck subsequently developed neck metastases. patients treated with voice conservation surgery +/- neck dissection +/- radiation (vcs +/- nd +/- r) had small transglottic carcinomas, whereas total laryngectomy +/- neck dissection +/- radiatio ... | 1984 | 6689996 |
| effects of dexamethasone on kinetics and distribution of triiodothyronine in the rat. | studies were designed to examine the effects of the glucocorticoid dexamethasone (dex) on the distribution and turnover of t3 separately from its effects on the pituitary and thyroid. male sprague-dawley rats (200-250 g) were surgically thyroidectomized and given a replacement dose of t4 (1.6 micrograms/day x 100 g bw) throughout the experiment via a sc implanted osmotic minipump. six or 7 days after starting the t4 infusion, each animal was given [125i]t3 by constant infusion (via a second mini ... | 1984 | 6690269 |
| l-thyroxine and 3,5,3'-triiodo-l-thyronine in rat embryos before onset of fetal thyroid function. | t4 and t3 have been measured by ria in 10-12-day-old rat embryo-trophoblasts, and in 13-20-day-old embryos and placentas, as well as in a few samples of amniotic fluid. both t4 and t3 were measured after extraction of the samples with ethanol, purification by paper chromatography, anion exchange resin, or both. t4 and t3 could be shown in all samples studied. the amounts of t4 and t3 per conceptus and their concentrations were higher in embryo-trophoblasts and placentas than in 13-18-day-old emb ... | 1984 | 6690276 |
| effect of dexamethasone on triiodothyronine production in the perfused rat liver and kidney. | dexamethasone administration to rats decreases t4-5'-deiodinase activity in liver homogenates and slices and in isolated rat renal tubules. to determine if this decreased t4-5'-deiodinase activity results in decreased t3 production, rat livers and kidneys of control and dexamethasone-treated rats were perfused with medium containing free t4 concentrations approximating euthyroid rat serum, and net t3 production was measured by ria. dexamethasone administration decreased body weight by 14% but di ... | 1984 | 6690278 |
| effect of thyroxine and growth hormone on the hypercholesterolemia of growth hormone deficiency. | to study the selective effect of thyroid hormone and growth hormone, alone and in combination on plasma cholesterol, 12 children were monitored monthly during three 4-month treatment periods. plasma cholesterol was unaltered by growth hormone therapy alone (mean +/- sd, basal cholesterol level: 202 +/- 26 mg/dl; cholesterol level after growth hormone 200 +/- 24 mg/dl). with thyroxine (t4) replacement alone, or combined with growth hormone, a significant (p less than 0.01) decrement in plasma cho ... | 1984 | 6690887 |
| thyroid status and muscle protein breakdown as assessed by urinary 3-methylhistidine excretion: study in thyrotoxic patients before and after treatment. | urinary 3-methylhistidine (3mh) excretion was studied in nine thyrotoxic patients before and after treatment. urinary creatinine (cr) output was also measured and was low in the thyrotoxic subjects before treatment. thus, although urinary output of 3mh was not greater than among the control population when expressed per subject, it was significantly elevated when expressed as the ratio of 3mh to cr; this ratio fell significantly, reaching normal control values after a euthyroid state was obtaine ... | 1984 | 6690888 |
| surgical management of locally advanced and recurrent breast cancer. | considerations for surgical treatment of locoregional recurrences of breast cancer are particularly relevant at a time when many primary breast malignancies are being treated in a more conservative manner. the past experience with local recurrence after radical mastectomy was dismal: every patient with recurrence eventually developed systemic disease. over 80% of such patients died within 2 years. the observations after local recurrence in patients with modified radical mastectomy are generally ... | 1984 | 6692275 |
| the effect of tamoxifen on bone mineral content in premenopausal women with breast cancer. | thirty-one of 62 consecutive premenopausal women with primary cancer of the breast completed a 1-year investigation period, receiving either 30 mg tamoxifen daily (15 patients) or placebo (16 patients). they were examined at the operation (t0) and at 3-month intervals (t1, t2, t3, and t4). bone mineral content (bmc) was measured at operation and after 12 months. fifty-six patients with benign tumors were included as healthy controls. all values of both cancer treatment groups and of the benign t ... | 1984 | 6692287 |
| defining a bacteriophage t4 late promoter: absence of a "-35" region. | we performed a deletion analysis to identify the minimal dna sequence required for the function of the t4 late promoter, p23. a minipromoter derivative of p23 was constructed, containing 35 bp of t4 dna from -18 to +17 with respect to the transcriptional initiation site. this derivative retains the tataaata homology and is competent to serve as a t4 late promoter both in vitro and in vivo. its transcriptional activity in vivo is regulated identically to a wild-type plasmid-borne p23, requiring t ... | 1984 | 6692468 |
| responses of t2-t4 spinal neurons to stimulation of the greater splanchnic nerves of the cat. | effects of electrical stimulation of the greater splanchnic nerves on t2-t4 spinal neurons were determined in 16 cats anesthetized with alpha-chloralose. of 77 neurons responding to somatic stimuli, 65 (84%) were excited, inhibited, or both excited and inhibited by splanchnic input. each of the splanchnic responsive cells also was responsive to electrical stimulation of cardiopulmonary sympathetic afferent fibers. all but one neuron with left splanchnic input also received input from the right s ... | 1984 | 6692869 |
| regulation of a bacteriophage t4 late gene, soc, which maps in an early region. | we have sequenced and analyzed the expression of an early region of the bacteriophage t4 genome that surprisingly contains a late gene, soc. soc is oriented in the same direction as early genes, like the t4 lysozyme gene. northern hybridization of early and late t4 rna, using cloned t4 restriction fragments as probes, identified two long early transcripts and a short late transcript, all containing the soc-coding sequence. thus, soc is transcribed both early and late. it is, however, translated ... | 1984 | 6693022 |
| the effects of propylthiouracil, iodothyronines, and other agents on thyroid hormone metabolism in human placenta. | human and rat placental homogenates contain inner ring deiodinase activity (pt4ase) towards t4 and t3. this activity may decrease the transfer of t4 and t3 across the placenta and influence thyroid hormone disposal in the fetal circulation. data are now presented on human pt4ase in subcellular fractions, the km of human pt4ase, and the effects of drugs and other compounds on human and rat pt4ase. the specific activity (nanograms of rt3 produced per min/mg protein) of each fraction of human place ... | 1984 | 6693538 |