Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| primary lymphomas in the gastrointestinal tract. | primary gastrointestinal (gi) lymphomas are uncommon diseases that can involve the whole gi tract. the etiologies of the disease remain unclear, and potential risk factors include celiac disease, helicobacter pylori infection, use of immunosuppressive agents, human immunodeficiency virus (hiv) or epstein-barr virus (ebv) infection and inflammatory bowel disease, etc. diffuse large b-cell lymphoma (dlbcl) and mucosa-associated lymphoid tissue (malt) lymphoma are the most common subtypes of gi lym ... | 2015 | 25678011 |
| [helicobacter pylori -- 2014]. | the author reviews the main achievements in helicobacter pylori research in the past 2 years. of the more than 1000 micrornas described thus far, sets of over- and underexpressed samples were identified that are associated with either gastric cancer or precancerous lesions, and some of them could be either markers or therapeutic targets in the near future. meta-analyses involved 95 new publications: the association between infection and oesophageal, colorectal, pancreatic and liver carcinomas is ... | 2015 | 25639633 |
| viruses, other pathogenic microorganisms and esophageal cancer. | esophageal cancer (ec) is the eighth most prevalent malignant tumor and the sixth leading cause of cancer mortality throughout the world. despite the technical developments in diagnosis and treatment, the 5-year survival rate is still low. the etiology of ec remains poorly understood; multiple risk factors may be involved and account for the great variation in ec incidence in different geographic regions. | 2015 | 26674173 |
| the participation of p53 and bcl-2 proteins in gastric carcinomas associated with helicobacterpylori and/or epstein-barr virus (ebv). | in the presented studies p53 and bcl-2 proteins expression were evaluated in samples of gastric carcinomas in patients with helicobacter pylori or ebv or without h. pylori/ebv infection. the studies were conducted on 64 adult patients with gastric adenocarcinomas: 16 patients with h. pylori (caga+)-positivity (group 1), 14 with ebv-positive tumours (group 2), 12 with h. pylori/ebv-positive tumours (group 3) and 22 patients with h. pylori/ebv-negative tumours (group 4). h. pylori presence in gast ... | 2015 | 26638529 |
| cancers in australia in 2010 attributable to infectious agents. | to estimate the proportion and numbers of cancers in australia in 2010 attributable to infectious agents. | 2015 | 26437730 |
| noncoding genomics in gastric cancer and the gastric precancerous cascade: pathogenesis and biomarkers. | gastric cancer is the fifth most common cancer and the third leading cause of cancer-related death, whose patterns vary among geographical regions and ethnicities. it is a multifactorial disease, and its development depends on infection by helicobacter pylori (h. pylori) and epstein-barr virus (ebv), host genetic factors, and environmental factors. the heterogeneity of the disease has begun to be unraveled by a comprehensive mutational evaluation of primary tumors. the low-abundance of mutations ... | 2015 | 26379360 |
| pathogenesis of gastric cancer. | gastric cancer (gc) is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. gc is a heterogeneous disease and the endpoint of a long multistep process largely influenced by helicobacter pylori infection, genetic susceptibility, and environmental factors. in a subset of gc cases, infection with the epstein-barr virus (ebv) may also be involved. the development of gc is the consequence of the accumulation of multiple epi/genetic changes during the patient ... | 2015 | 26372822 |
| silicone implants and lymphoma: the role of inflammation. | the risk of hematological malignancies is mainly determined by genetic background, age, sex, race and ethnicity, geographic location, exposure to certain chemicals and radiation; along with the more recently proposed immune factors such as chronic inflammation, immunodeficiencies, autoimmunity, and infections. paradigmatic examples include the development of lymphoma in sjögren's syndrome and hashimoto thyroiditis, gastric malt lymphoma in helicobacter pylori infection, or lymphomas associated w ... | 2015 | 26330346 |
| infection-associated non-hodgkin lymphomas. | non-hodgkin lymphomas (nhls) are malignant proliferations of lymphoid cells. lymphoid cells proliferate in a physiological manner in response to antigen-dependent and antigen-independent signals. some lymphotropic viruses, such as epstein-barr virus and human t-lymphotropic virus 1, as well as pathogens leading to chronic antigenic stimulation (such as helicobacter pylori and hepatitis c virus), are associated with nhl. we review here some of the pathophysiological features of infection-associat ... | 2015 | 26253291 |
| epidemiology of infectious meningitis in the state of amazonas, brazil. | in the state of amazonas, particularly in the capital manaus, meningitis has affected populations of different cultures and social strata over the years. bacterial meningitis is caused by several different species and represents a major issue of public health importance. the present study reports the meningitis case numbers with different etiologies in amazonas from january 1976 to december 2012. | 2015 | 26061374 |
| cancer-associated infectious agents and epigenetic regulation. | infectious agents are one of the factors which contribute to cancer development. few examples include human papilloma virus in cervical cancer, hepatitis virus in hepatocellular carcinoma, herpes virus in kaposi's sarcoma, epstein-barr virus in nasopharyngeal carcinoma, human t-cell lymphotropic virus type-1 (htlv-1) in t-cell leukemia and lymphoma, helicobacter pylori in gastric cancer. these agents cause genomic instability in the host and most of them affect host immune system. infectious age ... | 2015 | 25421669 |
| human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma in the pericardium: a case with latency type iii epstein-barr virus infection showing good prognosis without chemotherapy. | primary effusion lymphoma (pel) is a rare subtype of non-hodgkin lymphoma that proliferates in body cavities without detectable masses. pel is universally associated with human herpes virus-8 (hhv-8) infection and has an aggressive prognosis. recently, an hhv-8-unrelated pel-like lymphoma that usually occurs in elderly individuals and follows a more indolent prognosis has been reported, and it is treated as a disease distinct from pel. however, its pathogenesis and prognostic factors have not be ... | 2015 | 26384578 |
| treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases. | widespread use of immunosuppressive drugs, both conventional disease-modifying antirheumatic drugs (cdmards) and biologic disease-modifying antirheumatic drugs (bdmards), in autoimmune rheumatic diseases (ards) has been found to be associated with the reactivation of underlying latent viruses. the clinical features of virus reactivation can sometimes mimic flare of the underlying ards. the correct diagnosis and management of such reactivation is crucial, as increasing the dose of immunosuppressi ... | 2015 | 26362747 |
| non hcv-related infectious cryoglobulinemia vasculitis: results from the french nationwide cryovas survey and systematic review of the literature. | in patients with infectious cryoglobulinemia vasculitis (cryovas) in the absence of hepatitis c virus infection, data on presentation, therapeutic management and outcome are lacking. we conducted a nationwide survey that included patients with hcv-negative cryovas. we describe here the presentation, therapeutic management and outcome of 18 patients with non-hcv infectious cryovas and 27 additional patients identified form a systematic review of the literature. we included 18 patients, mean age 5 ... | 2015 | 26320984 |
| [skin disorder as an indication of viral infection]. | gianotti-crosti syndrome (gcs) is a dermatosis primarily affecting children between 2 and 6 years of age. it is characterized by multiple, itching, monomorphous, pink to red-brown papules or papulovesicles between 1 and 5 mm in size. gcs is associated with viral infections such as hepatitis b virus and epstein-barr virus (ebv). it is often accompanied by fever, hepatosplenomegaly and lymphadenopathy. the syndrome is self-limiting and disappears within 2 months. no treatment is therefore required ... | 2015 | 26083843 |
| interaction of human tumor viruses with host cell surface receptors and cell entry. | currently, seven viruses, namely epstein-barr virus (ebv), kaposi's sarcoma-associated herpes virus (kshv), high-risk human papillomaviruses (hpvs), merkel cell polyomavirus (mcpyv), hepatitis b virus (hbv), hepatitis c virus (hcv) and human t cell lymphotropic virus type 1 (htlv-1), have been described to be consistently associated with different types of human cancer. these oncogenic viruses belong to distinct viral families, display diverse cell tropism and cause different malignancies. a key ... | 2015 | 26008702 |
| reversible methotrexate-associated lymphoma of the liver in rheumatoid arthritis: a unique case of primary hepatic lymphoma. | primary hepatic lymphoma (phl) is an extremely rare disease, frequently associated with viruses such as hepatitis b virus (hbv), hepatitis c virus (hcv), and human immune deficiency virus (hiv). on the other hand, an increased risk of lymphoproliferative disorders (lpd) has been demonstrated in patients treated with immunosuppressive drugs such as methotrexate (mtx) for rheumatoid arthritis (ra). the role of epstein-barr virus (ebv) has been discussed in the pathogenesis of the immunodeficiency- ... | 2015 | 25964853 |
| no significant viral transcription detected in whole breast cancer transcriptomes. | studies evaluating the presence of viral sequences in breast cancer (bc), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. most were based on rt-pcr and in situ hybridization. | 2015 | 25884932 |
| il-35 inhibits hbv antigen-specific ifn-γ-producing ctls in vitro. | interleukin (il)-35 is an inhibitory cytokine consisting of il-12a and epstein-barr virus-induced gene 3 (ebi3) and is required by regulatory t-cells (tregs) for maximal activity. during chronic hepatitis b virus (hbv) infection, tregs have immunosuppressive effects on hbv-specific t helper (th) cells, yet little is known about the complex regulation of tregs and their contribution to the inadequate immune system response to the virus. in the present study, we investigated whether il-35 is invol ... | 2015 | 25869609 |
| serodiagnosis for tumor viruses. | the known human tumor viruses include the dna viruses epstein-barr virus (ebv), kaposi sarcoma herpesvirus (kshv), merkel cell polyomavirus (mcpyv), human papillomavirus (hpv), and hepatitis b virus (bv). rna tumor viruses include human t-cell lymphotrophic virus type 1 (htlv-1) and hepatitis c virus (hcv). the serological identification of antigens/antibodies in serum is a rapidly progressing field with utility for both scientists and clinicians. serology is useful for conducting seroepidemiolo ... | 2015 | 25843726 |
| oncogenic virus infections in the general population and end-stage renal disease patients with special emphasis on kaposi's sarcoma associated herpes virus (kshv) in northeast of iran. | globally, almost 20% of cancers are related to infectious agents that can be prevented. oncogenicity refers to viruses that may cause cancers, more importantly in immunocompromised subjects such as transplant and hemodialysis patients. therefore, epidemiological studies are the first line for understanding the importance of these agents in public health, particularly, in mobile populations, tourism and pilgrimage regions. | 2015 | 25834713 |
| clinical implications of hepatitis b viral infection in epstein-barr virus-associated nasopharyngeal carcinoma. | little is known about the clinical implication of hepatitis b virus (hbv) infection in epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc). | 2015 | 25728081 |
| [il-35 level of peripheral blood is correlated with the immune response to hepatitis b vaccine]. | to investigate the relationship of il-35 level in peripheral blood mononuclear cells (pbmcs) and immune response to hepatitis b vaccine and explore the factors influencing vaccine immune reaction. | 2015 | 25575066 |
| acute hepatitis e virus infection with coincident reactivation of epstein-barr virus infection in an immunosuppressed patient with rheumatoid arthritis: a case report. | hepatitis e virus (hev) is the most recently discovered of the hepatotropic viruses, and is considered an emerging pathogen in developed countries with the possibility of fulminant hepatitis in immunocompromised patients. especially in the latter elevated transaminases should be taken as a clue to consider hev infection, as it can be treated by discontinuation of immunosuppression and/or ribavirin therapy. to our best knowledge, this is a unique case of autochthonous hev infection with coinciden ... | 2015 | 26511098 |
| epstein-barr virus and interleukin-28b polymorphism in the prediction of response to interferon therapy in hepatitis c patients. | in chronic hepatitis c virus (hcv), viral and host factors are known to be predictors for anti-viral therapy. il-28b genotype strongly influences treatment outcome, while epstein-barr virus (ebv) co-infection could accelerate the course of chronic hcv infection. this study was conducted to assess whether ebv co-infection adds to the predictive value of il-28b. | 2015 | 26526510 |
| pre-stimulation of cd81 expression by resting b cells increases proliferation following ebv infection, but the overexpression of cd81 induces the apoptosis of ebv-transformed b cells. | hepatitis c virus (hcv) e2 protein binds to cd81, which is a component of the b cell co-stimulatory complex. the e2-cd81 interaction leads to b cell proliferation, protein tyrosine phosphorylation and to the hypermutation of immunoglobulin genes. epidemiological studies have reported a high prevalence of b cell non-hodgkin lymphoma (nhl) in hcv-positive patients, suggesting a potential association between hcv and epstein-barr virus (ebv) in the genesis of b lymphocyte proliferative disorders. in ... | 2015 | 26498453 |
| evidence for a vascular microbiome and its role in vessel health and disease. | we have summarized available evidence for and against the presence of a vascular microbiome. studies that have attempted to detect bacteria and viruses in blood vessels in both health and disease are critiqued in an attempt to explain contrary results that may be due to variations in methodology. | 2015 | 26002032 |
| microenvironmental abnormalities induced by viral cooperation: impact on lymphomagenesis. | when stringent criteria have been used, the epstein barr virus (ebv), the kaposi's sarcoma herpesvirus (kshv), human immunodeficiency virus type 1 (hiv-1) and human hepatitis c virus (hcv) have been identified with sufficient evidence to be causative agents of non-hodgkin's lymphomas. initially, single viral infection was considered fully responsible for the oncogenic properties of each virus, while it is now established that in many cases, multiple viral agents collaborate as cofactors in induc ... | 2015 | 25837157 |
| lessons from rare tumors: hepatic lymphoepithelioma-like carcinomas. | in this review we focus on lymphoepithelioma-like hepatocellular carcinomas (lel-hcc) and lymphoepithelioma-like cholangiocarcinomas (lel-icc). despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune system and neoplastic cells. approximately half of lel-hcc arise in the context of chronic hepatitis c virus (hcv) infection and have been described both in easter ... | 2015 | 25834311 |
| polymerase chain reaction in unilateral cases of presumed viral anterior uveitis. | anterior uveitis is the most common form of intraocular inflammation. the main aim of this study was to determine the viral etiology in patients with unilateral cases of anterior uveitis. | 2015 | 26715836 |
| association of interferon lambda-1 with herpes simplex viruses-1 and -2, epstein-barr virus, and human cytomegalovirus in chronic periodontitis. | periodontal tissues facilitate the homing of herpes viruses that elicit the immune-inflammatory response releasing the interferons (ifn). ifn lambda-1 (λ1) can suppress the replication of viruses, and induces the antiviral mechanism. the aim of the present study was to evaluate the association between ifn-λ1 and periodontal herpes viruses in the immunoregulation of chronic periodontal disease. | 2015 | 26677065 |
| efficacy of the nd:yag laser therapy on ebv and hsv1 contamination in periodontal pockets. | the aim of this retrospective multicenter study was to verify the efficacy of nd:yag laser in the treatment of periodontal pockets infected by epstein-barr virus (ebv) and herpes simplex virus 1 (hsv1). | 2015 | 26519745 |
| functional characterization of glycoprotein h chimeras composed of conserved domains of the pseudorabies virus and herpes simplex virus 1 homologs. | membrane fusion is indispensable for entry of enveloped viruses into host cells. the conserved core fusion machinery of the herpesviridae consists of glycoprotein b (gb) and the gh/gl complex. recently, crystal structures of gh/gl of herpes simplex virus 2 (hsv-2) and epstein-barr virus and of a core fragment of pseudorabies virus (prv) gh identified four structurally conserved gh domains. to investigate functional conservation, chimeric genes encoding combinations of individual domains of prv a ... | 2015 | 26491153 |
| stat3 regulates lytic activation of kaposi's sarcoma-associated herpesvirus. | lytic activation of kaposi's sarcoma-associated herpesvirus (kshv) from latency is a critical contributor to pathogenesis and progression of kshv-mediated disease. development of targeted treatment strategies and improvement of lytic-phase-directed oncolytic therapies, therefore, hinge on gaining a better understanding of latency-to-lytic-phase transition. a key observation in that regard, also common to other herpesviruses, is the partial permissiveness of latently infected cells to lytic-cycle ... | 2015 | 26339061 |
| l particles transmit viral proteins from herpes simplex virus 1-infected mature dendritic cells to uninfected bystander cells, inducing cd83 downmodulation. | mature dendritic cells (mdcs) are known as the most potent antigen-presenting cells (apcs) since they are also able to prime/induce naive t cells. thus, mdcs play a pivotal role during the induction of antiviral immune responses. remarkably, the cell surface molecule cd83, which was shown to have costimulatory properties, is targeted by herpes simplex virus 1 (hsv-1) for viral immune escape. infection of mdcs with hsv-1 results in downmodulation of cd83, resulting in reduced t cell stimulation. ... | 2015 | 26311871 |
| periodontal herpesviruses: prevalence, pathogenicity, systemic risk. | periodontitis is an infectious/inflammatory disease characterized by the loss of periodontal ligament and alveolar bone. herpesviruses are frequent inhabitants of periodontitis lesions, and the periodontopathogenicity of these viruses is the topic of this review. in 26 recent studies from 15 countries, subgingival cytomegalovirus, epstein-barr virus and herpes simplex virus type 1, respectively, yielded median prevalences of 49%, 45% and 63% in aggressive periodontitis, 40%, 32% and 45% in chron ... | 2015 | 26252400 |
| icacinlactone h and icacintrichantholide from the tuber of icacina trichantha. | the 17-norpimarane diterpene is a small group of natural products. a new member, icacinlactone h (1), and a new rearranged 17-norpimarane with an unprecedented carbon skeleton, icacintrichantholide (2), were isolated from icacina trichantha. their structures including the absolute configuration were elucidated by spectroscopic analysis, single-crystal x-ray diffraction, and electronic circular dichroism analysis. a plausible biogenetic pathway for 1 and 2 is proposed. both 1 and 2 showed no sign ... | 2015 | 26183449 |
| using proximity biotinylation to detect herpesvirus entry glycoprotein interactions: limitations for integral membrane glycoproteins. | herpesvirus entry into cells requires coordinated interactions among several viral transmembrane glycoproteins. viral glycoproteins bind to receptors and interact with other glycoproteins to trigger virus-cell membrane fusion. details of these glycoprotein interactions are not well understood because they are likely transient and/or low affinity. proximity biotinylation is a promising protein-protein interaction assay that can capture transient interactions in live cells. one protein is linked t ... | 2015 | 25958131 |
| [role of viruses with oncogenic potential and their associations in oncogenesis in maxillofacial area]. | the potential role of viruses with oncogenic potential such as human papilloma virus, cytomegalovirus, epstein-barr virus, herpes simplex virus type 1 and 2, herpes virus type 6, in the development of benign and pre-cancerous tumors of maxillofacial region was assessed in the study. we examined 26 patients with tumors in maxillofacial region (skin and mucosa) using molecular-genetic and histological studies of surgically removed neoplasms removed. in 53.8% of the examined samples dna of epstein- ... | 2015 | 25909609 |
| the pros and cons of autophagic flux among herpesviruses. | autophagy has been intensively studied in herpes simplex virus type 1 (hsv-1), a human alphaherpesvirus. the hsv-1 genome encodes a well-known neurovirulence protein called icp34.5. when the gene encoding this protein is deleted from the genome, the virus is markedly less virulent when injected into the brains of animal models. subsequent characterization of icp34.5 established that the neurovirulence protein interacts with becn1, thereby inhibiting autophagy and facilitating viral replication i ... | 2015 | 25905782 |
| reactivation of herpes simplex type 1 in pneumococcal meningitis. | acute bacterial meningitis (abm) and herpes simplex type 1 (hsv-1) encephalitis are two rare but serious infections affecting the central nervous system (cns). concurrent bacterial and viral cns infection has occasionally been reported. | 2015 | 25866347 |
| anti-cytokine autoantibodies in postherpetic neuralgia. | the mechanisms by which varicella zoster virus (vzv) reactivation causes postherpetic neuralgia (phn), a debilitating chronic pain condition, have not been fully elucidated. based on previous studies identifying a causative role for anti-cytokine autoantibodies in patients with opportunistic infections, we explored this possibility in phn. | 2015 | 26482341 |
| herpes viruses and human papilloma virus in nasal polyposis and controls. | chronic rhinosinusitis with nasal polyps is a multifactorial disease entity with an unclear pathogenesis. contradictory data exist in the literature on the potential implication of viral elements in adult patients with chronic rhinosinusitis. | 2015 | 26480900 |
| association of serum epstein-barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis. | multiple sclerosis (ms) is associated with epstein-barr virus (ebv) infection. a characteristic feature of ms is an intrathecal synthesis of immunoglobulin (ig)g. in 90 patients with clinically isolated syndromes/early relapsing-remitting ms, serum antibodies to epstein-barr nuclear antigen-1, but not to ebv viral capsid antigen, rubella, or varicella zoster virus, were higher (p=0.03) in those with than those without a calculated intrathecal igg synthesis >0% and correlated with the percentage ... | 2015 | 26198934 |
| virus-associated hemophagocytic syndrome in renal transplant recipients: report of 2 cases from a single center. | virus-associated hemophagocytic syndrome (hps) is a potentially fatal complication of immunosuppression for transplantation. however, it presents with heterogeneous clinical symptoms (fever, disturbed consciousness, and hepatosplenomegaly) and laboratory findings (pancytopenia, elevated hepatic enzyme levels, abnormal coagulation, and hyperferritinemia), impeding diagnosis. case 1: a 39-year-old female developed fever 4 years after abo-incompatible living-related renal transplantation. laborator ... | 2015 | 25838952 |
| viral infections in acute graft-versus-host disease: a review of diagnostic and therapeutic approaches. | while immunosuppressive therapy for acute graft-versus-host disease (agvhd) advances, viral reactivation has been found to be an increasingly common complication in these patients. dermatologists may often be consulted on inpatient services for evaluation. | 2015 | 25582535 |
| lack of association between human herpesvirus and vestibular schwannoma: analysis of 121 cases. | to assess for the presence of human herpesvirus (hhv) using immunohistochemical and polymerase chain reaction (pcr) assay in surgically excised vestibular schwannoma (vs) samples. | 2015 | 25560404 |
| autophagic flux without a block differentiates varicella-zoster virus infection from herpes simplex virus infection. | autophagy is a process by which misfolded and damaged proteins are sequestered into autophagosomes, before degradation in and recycling from lysosomes. we have extensively studied the role of autophagy in varicella-zoster virus (vzv) infection, and have observed that vesicular cells are filled with >100 autophagosomes that are easily detectable after immunolabeling for the lc3 protein. to confirm our hypothesis that increased autophagosome formation was not secondary to a block, we examined all ... | 2015 | 25535384 |
| human polyomavirus 6 dna in the cerebrospinal fluid of an hiv-positive patient with leukoencephalopathy. | leukoencephalopathies in haart-treated, hiv-positive patients include progressive multifocal leukoencephalopathy (pml), a result of lytic infection oligodendrocytes by jc polyomavirus (jcv), and another form characterized by the absence of jcv genome in cerebrospinal fluid (csf). | 2015 | 26071330 |
| bh3 profiling reveals selectivity by herpesviruses for specific bcl-2 proteins to mediate survival of latently infected cells. | herpesviruses, including human cytomegalovirus (hcmv), epstein-barr virus (ebv), and kaposi's sarcoma-associated herpesvirus, establish latency by modulating or mimicking antiapoptotic bcl-2 proteins to promote survival of carrier cells. bh3 profiling, which assesses the contribution of bcl-2 proteins towards cellular survival, was able to globally determine the level of dependence on individual cellular and viral bcl-2 proteins within latently infected cells. moreover, bh3 profiling predicted t ... | 2015 | 25740993 |
| infection history determines the differentiation state of human cd8+ t cells. | after the resolution of the acute phase of infection, otherwise quiescent antigen-experienced cd8(+) t cells confer rapid protection upon reinfection with viral pathogens or, in the case of persistent viruses, help to maintain control of the infection. depending on the type of virus, antigen-specific cd8(+) t cells have distinct traits, ranging from typical memory cell properties in the case of rapidly cleared viruses to immediate effector functions for persistent viruses. we here show that both ... | 2015 | 25717102 |
| prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among japanese subjects. | the association between human cytomegalovirus (hcmv) and glioblastoma multiforme (gbm) is becoming a new concept. however, information on the geographic variability of hcmv prevalence in gbm remains scarce. moreover, the potential roles of various viruses, such as polyomaviruses and oncogenic viruses, in gliomagenesis remain unclear. our aim was to investigate the prevalence of hcmv in gbm among japanese patients. furthermore, this was the first study that evaluated infection with four new human ... | 2015 | 25685179 |
| human cytomegalovirus and epstein-barr virus infection in inflammatory bowel disease: need for mucosal viral load measurement. | to evaluate the best diagnostic technique and risk factors of the human cytomegalovirus (hcmv) and epstein-barr virus (ebv) infection in inflammatory bowel disease (ibd). | 2015 | 25684960 |
| standardization of nucleic acid tests for clinical measurements of bacteria and viruses. | nucleic acid-based tests for infectious diseases currently used in the clinical laboratory and in point-of-care devices are diverse. measurement challenges associated with standardization of quantitative viral load testing are discussed in relation to human cytomegalovirus, bk virus, and epstein-barr virus, while the importance of defining the performance of qualitative methods is illustrated with mycobacterium tuberculosis and influenza virus. the development of certified reference materials wh ... | 2015 | 25392365 |
| a viral pilot for hcmv navigation? | gh/gl virion envelope glycoprotein complexes of herpesviruses serve as entry complexes and mediate viral cell tropism. by binding additional viral proteins, gh/gl forms multimeric complexes which bind to specific host cell receptors. both epstein-barr virus (ebv) and human cytomegalovirus (hcmv) express alternative multimeric gh/gl complexes. relative amounts of these alternative complexes in the viral envelope determine which host cells are preferentially infected. host cells of ebv can modulat ... | 2015 | 26184287 |
| human cytomegalovirus gh/gl/go promotes the fusion step of entry into all cell types, whereas gh/gl/ul128-131 broadens virus tropism through a distinct mechanism. | interaction between gh/gl and the fusion protein gb is likely a conserved feature of the entry mechanism for all herpesviruses. human cytomegalovirus (hcmv) gh/gl can be bound by go or by the set of proteins ul128, ul130, and ul131, forming gh/gl/go and gh/gl/ul128-131. the mechanisms by which these complexes facilitate entry are poorly understood. mutants lacking ul128-131 replicate well on fibroblasts but fail to enter epithelial/endothelial cells, and this has led to the general assumption th ... | 2015 | 26085146 |
| recurrent ocular surface inflammation associated with human herpesvirus 6 infection. | to report a case of atypical herpes keratitis and bilateral conjunctivitis associated with human herpesvirus 6 (hhv-6). | 2015 | 24296955 |
| immunohistochemistry in the diagnosis of cutaneous viral infections--part i. cutaneous viral infections by herpesviruses and papillomaviruses. | cutaneous viral infections are of increasing clinical importance, particularly in patients who are immunocompromised. | 2015 | 25171431 |
| scanning mutagenesis of human cytomegalovirus glycoprotein gh/gl. | the core, conserved function of the herpesvirus gh/gl is to promote gb-mediated membrane fusion during entry, although the mechanism is poorly understood. the human cytomegalovirus (hcmv) gh/gl can exist as either the gh/gl/go trimer or the gh/gl/ul128/ul130/ul131 (gh/gl/ul128-131) pentamer. one model suggests that gh/gl/go provides the core fusion role during entry into all cells within the broad tropism of hcmv, whereas gh/gl/ul128-131 acts at an earlier stage, by a distinct receptor-binding m ... | 2015 | 26656708 |
| prevalence of human cytomegalovirus and epstein-barr virus in chronic periapical lesions. | the aim of this study was to investigate the presence of human cytomegalovirus (hcmv) and epstein-barr virus (ebv) in the tissue of chronic periapical lesions, and to compare the results in relation to the symptoms of patients and the size of the lesion. | 2015 | 26551881 |
| distinct viral and mutational spectrum of endemic burkitt lymphoma. | endemic burkitt lymphoma (ebl) is primarily found in children in equatorial regions and represents the first historical example of a virus-associated human malignancy. although epstein-barr virus (ebv) infection and myc translocations are hallmarks of the disease, it is unclear whether other factors may contribute to its development. we performed rna-seq on 20 ebl cases from uganda and showed that the mutational and viral landscape of ebl is more complex than previously reported. first, we found ... | 2015 | 26468873 |
| human cytomegalovirus and epstein-barr virus genotypes in apical periodontitis lesions. | different genotypes of human cytomegalovirus (hcmv) and epstein-barr virus (ebv) possess specific pathogenic abilities because of various interactions with the host's immune system and differences in cell tropism. the aim of this study was to determine the distribution of hcmv and ebv genotypes in apical periodontitis lesions in relation to their clinical and histopathologic features. | 2015 | 26435468 |
| quantification of epstein-barr virus and human cytomegalovirus in chronic periodontal patients. | although studies focused mainly on the identification of periopathogenic bacteria, recent reports have suggested that various herpes viruses may also be involved in the occurrence and progression of different forms of periodontal diseases. | 2015 | 26322203 |
| approaches for monitoring of non virus-specific and virus-specific t-cell response in solid organ transplantation and their clinical applications. | opportunistic viral infections are still a major complication following solid organ transplantation. immune monitoring may allow the identification of patients at risk of infection and, eventually, the modulation of immunosuppressive strategies. immune monitoring can be performed using virus-specific and non virus-specific assays. this article describes and summarizes the pros and cons of the different technical approaches. among the assays based on non virus-specific antigens, the enumeration o ... | 2015 | 26305832 |
| viral etiology of mumps-like illnesses in suspected mumps cases reported in catalonia, spain. | we investigated the etiology of reported sporadic suspected mumps cases with a negative rt-pcr result for the mumps virus in the barcelona-south region in 2007-2011. samples from mumps virus-negative patients presenting unilateral or bilateral parotitis or other salivary gland swelling were tested for epstein-barr virus (ebv) by real-time pcr and for respiratory viruses by two multiplex-pcr-based assays to detect parainfluenza virus (piv) 1-4, influenza virus (inv) a, b and c, respiratory syncyt ... | 2015 | 25483547 |
| detection of herpesviruses and human papillomavirus in acute apical abscesses by real-time pcr. | the recent use of polymerase chain reaction (pcr)-based molecular methods to detect herpesviruses in periradicular lesions has suggested that some herpesviruses, especially human cytomegalovirus (hcmv) and epstein-barr virus (ebv) can participate in the pathogenesis of the periradicular lesions. based on the applicability of molecular techniques for virus identification, the aim of the study was to investigate the presence of hcmv, ebv, and human papillomavirus (hpv) in samples from acute apical ... | 2015 | 24802632 |
| cerebellar ebv-associated diffuse large b cell lymphoma following angioimmunoblastic t cell lymphoma. | epstein-barr virus (ebv)-associated b cell lymphoproliferative disorders may be seen in patients with angioimmunoblastic t cell lymphoma (aitl). although both nodal and extranodal sites of involvement have been described, central nervous system involvement by b cell lymphoma following aitl has not previously been documented. we report a first example of such unusual presentation, in which an 80-year-old man developed diffuse large b cell lymphoma (dlbcl) in the cerebellum 4 months after the init ... | 2015 | 27559423 |
| hla associations and risk of posttransplant lymphoproliferative disorder in a danish population-based cohort. | posttransplant lymphoproliferative disorder (ptld) is a feared complication to organ transplantation, associated with substantial morbidity and inferior survival. risk factors for ptld include t cell-depleting induction therapy and primary infection or reactivation of epstein-barr virus. possible associations between certain hla types and the risk of developing ptld have been reported by other investigators; however, results are conflicting. | 2015 | 27500227 |
| chronic physical stress does not interact with epstein-barr virus (ebv)-encoded dutpase to alter the sickness response. | most adult humans have been infected with epstein-barr virus (ebv), which is thought to contribute to the development of chronic fatigue syndrome. stress is known to influence the immune system and can exacerbate the sickness response. although a role for psychological stress in the sickness response, particularly in combination with ebv-encoded deoxyuridine triphosphate nucleotidohydrolase (dutpase) has been established, and the role of physical stressors in these interactions remains unspecifi ... | 2015 | 27175311 |
| a case of lymphomatoid granulomatosis presenting with cutaneous lesions. | 2015 | 27051739 | |
| atypical hydroa vacciniforme mimicking dermatomyositis: a case report in a lebanese girl. | 2015 | 27051685 | |
| epstein-barr virus ebna-2 polymorphic patterns in nasopharyngeal carcinoma in southern china. | the aim of this study was to characterize the specific epstein-barr virus (ebv) polymorphisms from nasopharyngeal carcinoma (npc) patients and healthy donors in southern china, and to explore the relationship between ebv genotypes and npc. | 2015 | 27070148 |
| [progress on the function of herpesvirus-encoded micrornas]. | since epstein barr virus was shown to encode micrornas(mirnas) in 2004, more than 470 mirnas have been discovered in α-, β-, and γ-herpesviruses. mirnas are small non-coding rna molecules and generally only have 18-25 nucleotides in length, which can regulate the expression of target genes by targeting its transcripts. herpesvirus-encoded mirnas not only target the key genes from latency to lytic replication, but also regulate various host cellular genes. current data manifest that herpesvirus-e ... | 2015 | 26951018 |
| extranodal nk/t-cell lymphoma, nasal type, presenting as a breast mass. | extranodal natural killer/t-cell lymphoma, nasal type, is a rare type of non-hodgkin cell lymphoma endemic to east asia and parts of central and south america. in most cases, it is driven by epstein-barr virus infections, with a broad range of morphologic appearances, frequent necrosis, and angioinvasion. it is designated as nk/t reflecting uncertainty in its cellular origins. these tumors usually arise in the nasal region, typically presenting with symptoms of nasal obstruction, epistaxis, and/ ... | 2015 | 26824008 |
| mir-1, regulated by lmp1, suppresses tumour growth and metastasis by targeting k-ras in nasopharyngeal carcinoma. | there is evidence to show that downregulation of mir-1 expression is closely related to cancer progression, including in nasopharyngeal carcinoma (npc). however, the molecular mechanisms underlying mir-1 downregulation in npc remain largely unknown, especially its association with epstein-barr virus (ebv). in this study we found that restoration of mir-1 dramatically inhibited cell invasion in vitro, together with tumour growth and metastasis in vivo. importantly, we found that lmp1, an epstein- ... | 2015 | 26852690 |
| epstein- barr virus: clinical and epidemiological revisits and genetic basis of oncogenesis. | epstein-barr virus (ebv) is classified as a member in the order herpesvirales, family herpesviridae, subfamily gammaherpesvirinae and the genus lymphocytovirus. the virus is an exclusively human pathogen and thus also termed as human herpesvirus 4 (hhv4). it was the first oncogenic virus recognized and has been incriminated in the causation of tumors of both lymphatic and epithelial nature. it was reported in some previous studies that 95% of the population worldwide are serologically positive t ... | 2015 | 26862355 |
| epstein-barr virus neurologic complications. | investigators at the karol marcinkowski university of medical sciences, poznan, poland, analyzed the records of 194 children diagnosed with epstein-barr virus infection and having the viral capsid antigen igm antibody. | 2015 | 26933545 |
| phosphoproteomic profiling reveals epstein-barr virus protein kinase integration of dna damage response and mitotic signaling. | epstein-barr virus (ebv) is etiologically linked to infectious mononucleosis and several human cancers. ebv encodes a conserved protein kinase bglf4 that plays a key role in the viral life cycle. to provide new insight into the host proteins regulated by bglf4, we utilized stable isotope labeling by amino acids in cell culture (silac)-based quantitative proteomics to compare site-specific phosphorylation in bglf4-expressing akata b cells. our analysis revealed bglf4-mediated hyperphosphorylation ... | 2015 | 26714015 |
| differential impact of two doses of antithymocyte globulin conditioning on lymphocyte recovery upon haploidentical hematopoietic stem cell transplantation. | in vivo depletion of host t cells with antithymocyte globulin (atg) is a common strategy for preventing graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (hsct). the total dose of atg in conditioning regimens appears to be an important factor that influences the outcome in recipients of transplants. however, the optimal atg dosage has not been established to date. it remains unclear whether, in the setting of haploidentical hsct (haplohsct), different doses of atg m ... | 2015 | 26715367 |
| [lung injury associated with severe epstein-barr virus (ebv) infection]. | severe epstein-barr (eb) virus infection is potentially a devastating process that often leads to death encountered in pediatrics recently. inappropriate control of eb virus replication may cause severe infection resulting in multiple organ dysfunction. however, little information is available on pulmonary complications associated with eb virus infection. the aim of the present study was to investigate severe eb virus (ebv) infection complicated with lung injury in pediatric intensive care unit ... | 2015 | 26717656 |
| identification of novel small organic compounds with diverse structures for the induction of epstein-barr virus (ebv) lytic cycle in ebv-positive epithelial malignancies. | phorbol esters, which are protein kinase c (pkc) activators, and histone deacetylase (hdac) inhibitors, which cause enhanced acetylation of cellular proteins, are the main classes of chemical inducers of epstein-barr virus (ebv) lytic cycle in latently ebv-infected cells acting through the pkc pathway. chemical inducers which induce ebv lytic cycle through alternative cellular pathways may aid in defining the mechanisms leading to lytic cycle reactivation and improve cells' responsiveness toward ... | 2015 | 26717578 |
| epstein-barr virus nuclear antigen 3 (ebna3) proteins regulate ebna2 binding to distinct rbpj genomic sites. | latent infection of b lymphocytes by epstein-barr virus (ebv) in vitro results in their immortalization into lymphoblastoid cell lines (lcls); this latency program is controlled by the ebna2 viral transcriptional activator, which targets promoters via rbpj, a dna binding protein in the notch signaling pathway. three other ebna3 proteins (ebna3a, ebna3b, and ebna3c) interact with rbpj to regulate cell gene expression. the mechanism by which ebnas regulate different genes via rbpj remains unclear. ... | 2015 | 26719268 |
| hydroa vacciniforme-like eruption associated with epstein-barr virus infection in an older adult. | 2015 | 26719662 | |
| meningitis and meningoencephalitis among israel defense force soldiers: 20 years experience at the hadassah medical centers. | meningitis and meningoencephalitis pose major risks of morbidity and mortality. | 2015 | 26757567 |
| acute acalculous cholecystitis by epstein-barr virus infection: a rare association. | acute acalculous cholecystitis (aac) is a rare complication of epstein barr virus (ebv) infection, with only a few cases reported among pediatric population. this clinical condition is frequently associated with a favorable outcome and, usually, a surgical intervention is not required. we report a 16-year-old girl who presented with aac following primary ebv infection. the diagnosis of aac was documented by clinical and ultrasonographic examination, whereas ebv infection was confirmed serologica ... | 2015 | 26753086 |
| levels of plasma epstein-barr virus dna prior and subsequent to treatment predicts the prognosis of nasopharyngeal carcinoma. | the level of epstein-barr virus dna (ebv-dna) in the plasma prior and subsequent to treatment is a reliable biomarker for the screening, diagnosis, monitoring and prognosis of nasopharyngeal carcinoma (npc). the present retrospective study aimed to determine whether pre- and post-treatment levels of plasma ebv-dna were predictive of survival in a large sample of patients with npc. the level of plasma ebv-dna in 637 npc patients prior and subsequent to treatment was determined by quantitative pol ... | 2015 | 26722258 |
| the prognostic role of eber in pediatric cancer. | the epstein-barr virus (ebv) infection is an endemic disease, over 90% of the population being exposed to it by adulthood. ebv is implicated in the etiology of a significant number of neoplasms, which acquire particular features in terms of course and prognosis. incidence rates are much higher in children. to establish the link between ebv and neoplasms, eber (epstein-barr virus non-encoded rnas) needs to be highlighted in tumor tissue. the role of ebv in patient response to oncological treatmen ... | 2015 | 26743271 |
| advances in understanding the pathogenesis of epstein-barr virus-associated lymphoproliferative disorders. | epstein-barr virus (ebv) was discovered 50 years ago from an african burkitt lymphoma cell line. ebv-associated lymphoproliferative disorders (lpds) are life- threatening diseases, especially in children. in this article, we review ebv-associated lpds, especially in the area of primary immunodeficiency disease (pid). we searched pubmed for publications with key words including ebv infection, lymphoma, lpds and pid, and selected the manuscripts written in english that we judged to be relevant to ... | 2015 | 26742434 |
| intraocular relapse with hypopyon and retinal infiltrates after chemotherapy and peripheral blood stem cell transplantation for extranodal nk/t-cell lymphoma. | we report a case of intraocular relapse of extranodal nk/t-cell lymphoma with anterior chamber hypopyon and retinal infiltrates. a 55-year-old man developed fever, malaise, anorexia, and hepatosplenomegaly, and was diagnosed with nk/t-cell lymphoma by liver biopsy. he underwent 2 courses of smile (dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide) chemotherapy, followed by myeloablative peripheral blood stem cell transplantation, donated by his brother. two months later, he ... | 2015 | 26763364 |
| enhanced antitumor effect of combining chemotherapy with epstein-barr virus (ebv)-specific cytotoxic t lymphocytes in mice with ebv-related non-hodgkin's lymphoma. | epstein-barr virus (ebv)-related non-hodgkin's lymphoma (nhl) represents a major problem in hematological clinical studies due to its drug tolerance and refractoriness. ebv infection is a key factor driving the process of tumor growth. immune therapy is an important biotherapeutic method of treating cancer, which is attracting increasing attention. we hypothesized that combining conventional chemotherapy with immune therapy in the treatment of ebv-related nhl may achieve better outcomes. first, ... | 2015 | 26807226 |
| [treatment strategy for gastric carcinoma with lymphoid stroma]. | gastric carcinoma with lymphoid stroma (gcls) is a histological type with severe lymphocytic infiltration. gcls is very rare and few cases have been reported. we examined the clinical features, problems of preoperative diagnosis, and treatment of 14 cases (1.8%) that were diagnosed as gcls out of 790 gastric cancers surgically resected in our hospital. the mean age was 69 years. six, 8, and 0 cases were located in the upper, middle, and lower fields of the stomach, respectively, and 8, 1, 4, and ... | 2015 | 26805251 |
| expression of ebv antibody ea-iga, rta-igg and vca-iga and sa in serum and the implication of combined assay in nasopharyngeal carcinoma diagnosis. | epstein-barr virus (ebv) is an important non-invasive index for nasopharyngeal carcinoma. serum sialic acid (sa) level was known to be related with tumor progression. rta protein antibody igg (rta-igg), early antigen antibody (ea-iga) and viral capsid antibody (vca-iga) levels in serum can also be used to effectively monitor the progression of cancer. this study investigated serum level of sa, rta-igg, ea-iga and vca-iga in nasopharyngeal cancer patients and the diagnostic value of combined assa ... | 2015 | 26884888 |
| prevalence and clinicopathologic features of cd30-positive de novo diffuse large b-cell lymphoma in chinese patients: a retrospective study of 232 cases. | diffuse large b-cell lymphoma (dlbcl) is a heterogeneous disease that great efforts had been made in to build up molecular and immunophenotypic subgroups that could relatively accurate indicate prognosis and give clue to therapy. recently, cd30 was reported as a useful predictor with favorable clinical outcome. however, cd30 expression patterns and the clinicopathologic features of cd30 positive dlbcl are not well described thus far, especially in asian patients. here, we studied 232 cases of de ... | 2015 | 26884853 |
| clinicopathologic features and treatment of breast metastasis from nasopharyngeal carcinoma: a report of two cases and literature review. | breast metastasis is a rare pattern of distant metastasis from nasopharyngeal carcinoma (npc) following curative treatment. the present study reported two patients with breast metastasis from npc and reviewed four such patients reported in the literature, including the analysis of clinical profiles, pathological diagnoses, treatment strategies and outcomes. the breast is a potential metastatic site for patients with npc following curative treatment; however, thus far, only metachronous breast me ... | 2015 | 26788190 |
| first case of primary intraocular natural killer t-cell lymphoma. | natural killer cell tumors can be broadly divided by origin into mature-cell and progenitor-cell types. the invasion of nasal-origin natural killer cells into the ophthalmologic field is sometimes observed in patients, but primary ocular natural killer cell tumors are a rare occurrence. | 2015 | 26585973 |
| [development of taqman-based real-time pcr assay for detection of epstein-barr virus dna]. | epstein-barr virus (ebv) is a human herpesvirus which infects almost all of the world's population subclinically during childhood and thereafter remains for a life. immunocompromised persons often show active ebv infection, which may progress to virus-associated lymphoproliferative disorders. many clinical researches show a strong role for viral load measurement in predicting and monitoring ebv-associated diseases, especially in immunosuppressed patients. the aim of this work was to design and t ... | 2015 | 26591663 |
| epstein-barr virus from burkitt lymphoma biopsies from africa and south america share novel lmp-1 promoter and gene variations. | epstein barr virus (ebv) sequence variation is thought to contribute to burkitt lymphoma (bl), but lack of data from primary bl tumors hampers efforts to test this hypothesis. we directly sequenced ebv from 12 bl biopsies from ghana, brazil, and argentina, aligned the obtained reads to the wild-type (wt) ebv reference sequence, and compared them with 100 published ebv genomes from normal and diseased people from around the world. the 12 bl ebvs were type 1. eleven clustered close to each other a ... | 2015 | 26593963 |
| lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: lessons from other inflammatory disorders. | immunosuppressive agents, such as thiopurines, methotrexate, and biologics, have revolutionized the treatment of inflammatory bowel disease (ibd). however, a number of case reports, case control studies and retrospective studies over the last decade have identified a concerning link between immunosuppression and lymphoproliferative disorders (lpds), the oncological phenomenon whereby lymphocytes divide uncontrollably. these lpds have been associated with epstein-barr virus (ebv) infection in whi ... | 2015 | 26600976 |
| the unexpected finding of a splenic infarction in a patient with infectious mononucleosis due to epstein-barr virus. | the authors present a case of a 24-year-old man with infectious mononucleosis (im) due to epstein-barr virus (ebv). among his symptoms, he reported abdominal pain in the upper left quadrant. an abdominal ultrasound and ct revealed an extensive splenic infarction. during the acute stage of this disease, the thrombophilic screening revealed reduced free protein s and elevated factor viii, with normalisation on re-evaluation 6 weeks later. splenic infarction is a very rare complication of im due to ... | 2015 | 26607191 |
| dynamic expression of viral and cellular micrornas in infectious mononucleosis caused by primary epstein-barr virus infection in children. | epstein-barr virus (ebv) was the first virus identified to encode micrornas (mirnas). both of viral and human cellular mirnas are important in ebv infection. however, the dynamic expression profile of mirnas during primary ebv infection was unknown. this study aimed to investigate the dynamic expression profile of viral and cellular mirnas in infectious mononucleosis (im) caused by primary ebv infection. | 2015 | 26634702 |