Publications

antigen-receptor complex stimulation triggers protein kinase c-dependent cd11a/cd18-cytoskeleton association in t lymphocytes.	although it is well accepted that intercellular adhesion involving the cd11a/cd18 (lfa-1) complex is critical in a wide array of t cell-dependent processes, recent demonstrations of an lfa-1 high avidity state, induced by triggering the t cell receptor (tcr) complex, has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling, as well as their orderly sequence. in this study, we assessed the effects of t cell activation on the actin-base ...	2006	1346786
tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy.	tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis. high-dose cyclophosphamide or high-dose melphalan are chemotherapeutic regimens associated with severe nausea and vomiting refractory to current antiemetic medications. we compared in a randomised open label study the antiemetic efficacy of tropisetron and alizapride in a first group of 32 consecutive patients treated with high-dose alkylating agent chemotherapy with or wi ...	2006	1828962
tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy.	tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis. high-dose cyclophosphamide or high-dose melphalan are chemotherapeutic regimens associated with severe nausea and vomiting refractory to current antiemetic medications. we compared in a randomised open label study the antiemetic efficacy of tropisetron and alizapride in a first group of 32 consecutive patients treated with high-dose alkylating agent chemotherapy with or wi ...	2006	1828962
otolaryngologic manifestations of child abuse.	currently, awareness is growing of child abuse in the medical and lay communities. to familiarize otolaryngologists with the head and neck findings in abused children, we retrospectively analyzed 85 patients admitted to an inner-city hospital with the diagnosis of abuse or neglect. forty-eight children (56%) had abnormalities within the head and neck region. excluding coincidental findings, 31 children (36%) had findings that could be directly linked to physical abuse or neglect. the face was th ...	2006	1637540
pharmacokinetics of sufentanil in the elderly surgical patient.	the effect of age on the distribution and elimination of sufentanil was studied in seven elderly (77 +/- 5 yr, mean +/- sd) and seven younger (41 +/- 15 yr) neurosurgical patients. following a single iv bolus of sufentanil 2 micrograms.kg-1 multiple arterial samples were obtained at timed intervals and plasma concentrations of sufentanil were measured by radioimmunoassay. pharmacokinetic variables were calculated from the derived compartmental models. the initial volume of distribution was signi ...	2006	2147593
[long-term follow-up after thyroidectomy: incidence of recurrent goiter and functional results].	we analyzed the postoperative longterm results after strumectomy for sporadic goiter in 26 patients. the follow-up time was 25.1 +/- 14.7 (7-58) years (x +/- sd, extremes). actual goiter recurrence without need for surgery was observed and sonographically confirmed in 3 patients, and 1 patient without actual recurrence had had a second strumectomy for goiter recurrence in the past. hence the overall frequency of goiter recurrence in this study is 15% (4/26 patients). the patients with a present ...	2006	1448680
pedigree analysis of children with phonology disorders.	this study examined 87 pedigrees of individuals with histories of preschool phonology disorders. results confirmed previous reports that speech and language disorders aggregate in families, with a higher incidence of males affected than females. significantly more family members with dyslexia and learning disabilities, but not stuttering or hearing impairment, were found in pedigrees of individuals with phonology disorders than in pedigrees of nondisabled individuals. probands with and without a ...	2006	1431544
[observations on the intraocular pressure after extracapsular cataract extraction].	the author observed the iop of 32 eyes after extracapsular cataract extraction with posterior chamber intraocular lens implantation. the iop was elevated in all cases, over 0.67 kpa (5 mmhg) in 22 cases, over 1.33 kpa (10 mmhg) in 12 cases, and the highest was 5.05 kpa (38 mmhg). the peak of elevation was at 24 hours after operation and most cases resumed the preoperative levels in 48 hours. the iop of eyes with intracameral carbachol was significantly lower than that of those without at 6 hours ...	2006	1860411
[conservative management of lymphedema of the limbs].	etiology and stadium of 63 lymphoedema patients are shown. the method of lymph-drainage therapy is discussed. important part of this treatment is bandaging. lymphamat pump (bösl) was successfully used as a part of the therapy. according to the good experiences it seems to be adviceable to use this method for treatment of limb lymphoedema. this method was successful in diuretics, venoruton, doxium and lymph-compress resistant cases.	2006	1866167
[post-traumatic synovitis at the level of the knee].		2006	2094111
they need more exercise.		2006	2376809
[pathology of myxoid mitral valve degeneration: literature review and personal results].	mitral prolapse is a parachute-like protrusion of the value into the left atrium. almost always a myxoid degeneration of the valve is the base of such a prolapse. myxoid degeneration is understood as dissolution of the collagenous fibrous layer and its replacement by acid glucosaminoglycans. an alteration of collagen is suspected as primary defect in this sometimes also inherited disorder. the electron microscope reveals fragmentation of collagen fibrils and elastic fibers and, within the myxoid ...	2006	1448633
recommendations on the use of ultrasound and doppler technology in clinical obstetrics and gynecology. figo study group on the assessment of new technology.		2005	1351013
prevalence studies of problematic behaviors in four-year-olds.	prevalence rates for specific behaviors in the problem behavior questionnaire (pbq; behar & stringfield, 1974) and for four psychosomatically related behaviors (soiling, day and night wetting, and complaints about bodily aches) were estimated in a sample of 377 swedish 4-year-olds described by their parents (mainly mothers). the results showed that several of the behaviors classified as outgoing conduct problems were common in this age group; boys showed more problematic behaviors than girls, as ...	2005	1287827
cocaine/polydrug use in pregnancy: two-year follow-up.	the impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. in the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants ex ...	2005	1370867
naproxen reduces idiopathic but not fibromyoma-induced menorrhagia.	to compare the effect of naproxen on idiopathic and myoma-induced menorrhagia, 11 women with myomatosus uterus and 14 women with idiopathic menorrhagia (menstrual blood loss greater than 80 ml) were treated in a double-blind trial with placebo or naproxen during four consecutive menstruations. placebo had no effect on menstrual blood loss. naproxen (500 to 1000 mg daily for five days) reduced menstrual blood loss by 35.7% in women with idiopathic menorrhagia, but it had no consistent effect on m ...	2005	3523328
t-lymphocytes and psoriasis.		2005	1087550
[further research on the differentiation in vitro of chick-embryo skin in the presence of histones].	in the present study the authors have carried out further researches on the differentiation of six day limb skin from chick embryo cultured "in vitro" in a complete medium supplemented with histones. when histones were added to the medium in the first two days "in vitro", epidermal keratinization was not observed. however the addition of histones after four days "in vitro" did not interfere with epidermal differentiation.	2005	548050
second reading for experiments bill.		2005	538875
editorial: misleading statistics.		2005	1247832
those dangerous roentgens and how to control them: ii radiation hazards and protection as they relate to exposures in dental radiography.		2005	1064920
effects of helicopter noise on pilots' hearing.		2005	1231074
gabaa receptors control the excitability of neuronal populations.		2005	1317365
letter: an easy death.		2005	1169095
[electric stimulation in psychiatry. myths and realities].		2005	538855
improved methodology and precision using a straight base line technique for the quantitation of proteins by two dimensional immunoelectrophoresis.		2005	1112067
[molecular bases of chronic granulomatous disease--analysis of the involvement of cytosol factors for nadph oxidase].	during the past 5 years, the discovery of cell-free superoxide generation system (bromberg y, pick e: cell immunol 88:213-221, 1984) has been revolutionized our understanding of phagocyte superoxide generation. using cell-free system, it was clarified that nadph oxidase for superoxide generation was comprised of components present in both the plasma membrane as well as in the cytosol. this oxidase could be kept inactive by keeping its components separated from each other within the cell and then ...	2005	1317471
acute toxicity of mevinphos to gerbils.		2005	1273839
[sisomicin dosage in renal failure].		2005	538909
[clinical syndromes with liver and kidney involvement in children and adults].	multiple pathogenetic mechanisms can lead to dysfunctions or malformations of the liver and kidneys in children and adults. the association of renal and hepatic abnormalities can be found in different congenital malformation syndromes. hereditary metabolic disorders are capable of alternating liver and kidney function. immunologic, toxic and septic diseases may damage both organ systems. in patients with liver cirrhosis, both glomerular and tubular dysfunctions can be observed. in the course of ...	2005	2685579
what's your diagnosis?		2005	1196062
gastrin and insulin release.		2005	1140520
the impact of laboratory error on the normal range: a bayesian model.	interpretation of clinical laboratory results, aside from clinical considerations, is based on the probability of the result being within a given normal range. this probability is influenced by the degree of error inherent in the analytical method. it would be advantageous to assign a more definite probability to the result of the measurement by combining the error distribution of the result around the true value and the distribution of the healthy population that serves as a reference. bayesian ...	2005	1112041
[the continuing education for specialist in internal medicine in the district of karl marx stadt].		2005	551566
interactions of praseodymium and neodymium with nucleosides and nucleotides: absorption difference and comparative absorption spectral study.	the interactions of praseodymium(iii) and neodymium(iii) with nucleosides and nucleotides have been studied in different stoichiometry in water and water-dmf mixtures by employing absorption difference and comparative absorption spectrophotometry. the 4f-4f bands were analysed by linear curve analysis followed by gaussian curve analysis, and various spectral parameters were computed, using partial and multiple regression method. the magnitude of changes in both energy interaction and intensity w ...	2005	1317348
[current etiopathogenic view of idiopathic hypertrophic subaortic stenosis. study of 3 brothers with this disease].		2005	1237159
[bronchopneumopathies due to cereals in grain silos workers: etiological and pathogenetical aspects].		2005	1226180
diarrhoeae in thyroid medullary carcinoma: role of prostaglandins and therapeutic effect of nutmeg.	in a patient with medullary carcinoma of the thyroid with pulmonary metastases who presented with diarrhoea and steatorrhoea large amounts of prostaglandin-like material were present in peripheral blood, and some was extracted from the tumour. the diarrhoea which persisted after thyroidectomy responded to treatment with nutmeg.	2005	1169097
[proceedings: case of right atrial dilatation].		2005	1160122
psychiatric morbidity in a sample of a london coroner's open verdicts.	one hundred and thirty-four deaths recorded as open verdicts in the inner west london coroner's district during 1969 and 1970 have been surveyed for evidence of mental illness. for 110 (82 per cent) of these deaths the probable verdicts were suicide or accident and they were reclassified as undetermined deaths. of these deaths 73 per cent were diagnosed as mentally ill, 54 per cent were receiving medical treatment for psychological symptoms before death, 42 per cent had a history of psychiatric ...	2005	1182365
phloroglucinol derivatives of eleven dryopteris species from japan.		2005	1197418
carcinoma of the male breast following thymic irradiation.	a white male teenager with carcinoma of the breast had received radiation therapy for an asymptomatic enlarged thymus on the second, fourth and seventh days of life. the dose delivered to the infant breasts, the latent period, and the unusually young age of the patient suggest that the malignancy was related to the course of radiotherapy.	2005	1153746
regulation of annexin i in adipogenesis: camp-independent action of methylisobutylxanthine.	the differentiation of 3t3-l1 fibroblasts to adipocytes can be accelerated by the addition of 1-methyl-3-isobutylxanthine (mix), insulin, and dexamethasone to the culture medium. during differentiation, we have demonstrated that the level of both annexin i mrna and protein decreases. the half-times for this reduction were 2 h and 10 h for annexin i mrna and protein, respectively. of the added agents in the differentiation medium, only mix caused a decline in annexin i expression in 3t3-l1 fibrob ...	2005	1370745
the aching mouth and the aching psyche.		2005	1074368
[living or dead language - contribution to its understanding in analysis in an institution. study of a clinical case].		2005	547298
universal dna primers amplify bacterial dna from human fetal membranes and link fusobacterium nucleatum with prolonged preterm membrane rupture.	a large number of bacterial species have been identified in fetal membranes after preterm labour (ptl) associated with intrauterine infection by microbiological culture. in this study, we have investigated a molecular and bioinformatic approach to organism identification which surmounts the need for specific and diverse microbiological culture conditions required by conventional methods. samples of fetal membranes were taken from 37 preterm infants, and 6 normal term controls delivered by caesar ...	2005	16254004
effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats.	bisphosphonates are potent inhibitors of bone resorption and were shown to inhibit bone resorption in experimental periodontitis by unknown mechanisms. we studied the effect of the aminobisphosphonate sodium alendronate (sa) in experimental periodontitis. wistar rats were subjected to ligature placement around the second upper left molars.	2005	16274309
coaggregation ability of weissella cibaria isolates with fusobacterium nucleatum and their adhesiveness to epithelial cells.	in the present study, we evaluated the ability of weissella cibaria isolated from the oral cavity to coaggregate with fusobacterium nucleatum, and the adhesiveness of these strains to epithelial cells. w. cibaria efficiently coaggregated with f. nucleatum, and adhered to epithelial cells. we tested the effects of various factors on the coaggregation. the coaggregation and adhesiveness of w. cibaria disappeared upon exposure to pronase or licl, suggesting that proteinaceous components on the surf ...	2005	16288835
streptococci dominate the diverse flora within buccal cells.	previously, we reported that intracellular actinobacillus actinomycetemcomitans, porphyromonas gingivalis, and tannerella forsythensis were present within buccal epithelial cells from human subjects, as lesser components of a polymicrobial flora. in this study, we further characterized that intracellular flora by using the same double-labeling techniques to identify fusobacterium nucleatum, prevotella intermedia, oral campylobacter species, eikenella corrodens, treponema denticola, gemella haemo ...	2005	16304448
enhanced pathogenicity of fusobacterium nucleatum adapted to oxidative stress.	fusobacterium nucleatum is an obligate anaerobic bacterium found in the indigenous human microbiota but also recovered from several anaerobic infections. considering the biological and medical relevance of f. nucleatum, the characterization of its response to oxidative stress is needed in order to understand how this anaerobic bacterium survives during an invasive process of oxygenated tissues. influence of oxidative stress by atmospheric oxygen exposure on cellular morphology and pathogenicity ...	2005	16125361
antibacterial activity of aqueous extracts of selected chewing sticks.	this aim of this study was to determine the antibacterial activity in extracts obtained from various nigerian chewing sticks. aqueous extracts from seventeen chewing sticks and the fruit of c. ferruginea, one fruit used in oral hygiene in nigeria, were screened for antibacterial activity against type cultures of staphylococcus aureus, bacillus subtilis, escherichia coli, and pseudomonas aeruginosa. eleven of the test extracts showed activity against at least two of these referenced organisms. mi ...	2005	16127476
development of strain-specific pcr primers based on a dna probe fu12 for the identification of fusobacterium nucleatum subsp. nucleatum atcc 25586t.	the objective of this study was to assess the strain-specificity of a dna probe, fu12, for fusobacterium nucleatum subsp. nucleatum atcc 25586t (f. nucleatum atcc 25586t), and to develop sets of strain-specific polymerase chain reaction (pcr) primers. strain-specificity was tested against 16 strains of f. nucleatum and 3 strains of distinct fusobacterium species. southern blot hybridization revealed that the fu12 reacted exclusively with the hindiii-digested genomic dna of f. nucleatum atcc 2558 ...	2005	16145547
in vitro method to assess the antimicrobial activity and potential efficacy of novel types of wound dressings.	to develop a simple, reproducible in vitro static diffusion method using cellulose disks and defined species to test antimicrobial efficacy of wound dressings.	2005	16162241
microflora in oral ecosystems in subjects with hyposalivation due to medicines or of unknown origin.	to analyse the microbial flora in specific sites in 20 dentate (> or = 16 teeth) subjects with hyposalivation due to medicines or of unknown origin and in 20 controls matched according to age, sex and number of teeth.	2005	16173383
increased antibacterial activity of zinc polycarboxylate cement by the addition of chlorhexidine gluconate in fixed prosthodontics.	this study evaluated the antibacterial activity of water-activated zinc polycarboxylate cement with adjunctive 0.12% chlorhexidine gluconate on the subgingival microbiota in fixed partial dentures.	2005	16220801
coaggregation profiles of the microflora from root surface caries lesions.	bacterial coaggregation reactions between different species and the auto aggregation of the same species are associated with the initiation and development of dental plaque and biofilms. as no such data is available on isolates from root caries lesions, we evaluated, by a visual, semi-quantitative scoring system and a spectrophotometric, quantitative assay, the coaggregation of 22 different wild-type microbial species comprising ten bacterial genera and a single candida spp. the quantitative coa ...	2005	15598414
synergy between tannerella forsythia and fusobacterium nucleatum in biofilm formation.	during dental plaque formation, the interaction of different organisms is important in the development of complex communities. fusobacterium nucleatum is considered a 'bridge-organism' that facilitates colonization of other bacteria by coaggregation-mediated mechanisms and possibly by making the environment conducive for oxygen intolerant anaerobes. these studies were carried out to determine whether coaggregation between f. nucleatum and tannerella forsythia is important in the formation of mix ...	2005	15612944
inhibitory effects of various micro-organisms on the growth of helicobacter pylori.	to examine the in vitro influence of various bacteria species on helicobacter pylori (hp) growth.	2005	15613007
fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells.	fusobacterium nucleatum is closely associated with human periodontal diseases and may also be a causative agent in other infections, such as pericarditis, septic arthritis, and abscesses of tonsils and liver. initiation and outcome of infective diseases depend critically on the host cell signaling system altered by the microbe. production of proteinases by infected cells is an important factor in pericellular tissue destruction and cell migration. we studied binding of f. nucleatum to human epit ...	2005	15664960
periodontal infections and pre-term low birth weight: a case-control study.	pre-term delivery of low-birth-weight infants [pre-term low birth weight (plbw)] remains a significant public health issue and a major cause of neonatal death and long-term health problems. there is a growing consensus that infections remote from fetal-placental unit may influence plbw infants. recent studies have suggested that maternal periodontal disease may be an independent risk factor for plbw. the purpose of the present study was to evaluate the possible link between periodontal infection ...	2005	15691348
dna-dna hybridization demonstrates multiple bacteria in osteoradionecrosis.	bone necrosis secondary to radiation was previously attributed to trauma of devitalized bone and microbiological sepsis. however, conventional microbiological technique has failed to demonstrate microorganisms throughout osteoradionecrotic bone, claimed to be hypoxic, hypovascular and hypocellular. the aim of the present study was to examine such bone for bacteria using dna-dna hybridization. compared to standard culture methods this technique enables the investigation of a vast number of bacter ...	2005	15695050
molecular analysis of microbial diversity in advanced caries.	real-time pcr analysis of the total bacterial load in advanced carious lesions has shown that the total load exceeds the number of cultivable bacteria. this suggests that an unresolved complexity exists in bacteria associated with advanced caries. in this report, the profile of the microflora of carious dentine was explored by using dna extracted from 10 lesions selected on the basis of comparable total microbial load and on the relative abundance of prevotella spp. using universal primers for t ...	2005	15695690
development and characterization of a simple perfused oral microcosm.	to validate perfused, inline, filter-based fermentation systems (multiple sorbarod devices, msd) for their ability to maintain stable oral bacterial communities. msd enable replicate (n=5) microcosm biofilms (bf) to be established and sampled, together with their perfusates (pa, cells in eluted medium).	2005	15715865
antimicrobial actions of benzimidazoles against oral streptococci.	benzimidazoles, such as lansoprazole and omeprazole, are used extensively as proton-pump inhibitors to control stomach acid secretion and also have antimicrobial actions against helicobacter pylori. our objective was to determine whether they are potentially useful antimicrobials against oral bacteria.	2005	15720569
impact of sample storage on detection of periodontal bacteria.	information on the impact of sample storage prior to analysis by dna methods is limited. the aim of this study was to investigate the effect of subgingival sample storage on bacterial detection and enumeration.	2005	15720575
thiazolidinedione (pioglitazone) blocks p. gingivalis- and f. nucleatum, but not e. coli, lipopolysaccharide (lps)-induced interleukin-6 (il-6) production in adipocytes.	an elevated level of c-reactive protein (crp) predicts the future development of coronary heart disease. periodontitis appears to up-regulate crp. crp is produced by hepatocytes in response to interleukin-6 (il-6). a major source of il-6 in obese subjects is adipocytes. we hypothesized that lipopolysaccharide (lps) from periodontal pathogens stimulated adipocytes to produce il-6, and that the production was suppressed by the drugs targeted against insulin resistance, thiazolidinedione (pioglitaz ...	2005	15723863
quantitative detection of volatile sulfur compound- producing microorganisms in oral specimens using real-time pcr.	it is well-known that some periodontopathic bacteria, especially porphyromonas gingivalis, fusobacterium nucleatum, tannerella forsythia (formerly bacteroides forsythus or tan. forsythensis), and treponema denticola, actively produce volatile sulfur compounds (vscs), such as h2s and ch3sh. we previously reported a qualitative relationship between periodontopathic bacteria and vscs; however, a quantitative analysis of periodontopathic bacteria in oral specimens is required for further characteriz ...	2005	15752104
[pharmacokinetic/pharmacodynamic analysis of antibiotic therapy in dentistry and stomatology].	this study evaluates the efficacy of various antimicrobial treatments for orofacial infections on the basis of pharmacokinetic/pharmacodynamic (pk/pd) criteria.	2005	15757581
bacteria recovered from dental pulp induce apoptosis of lymph node cells.	apoptosis is critical in the pathogenesis of several infectious diseases. the induction of apoptosis was assessed in mouse lymph node cells by four bacteria recovered from infected human dental pulp: gemella morbillorum, clostridium butyricum, fusobacterium nucleatum and bifidobacterium adolescentis. smaller lymph nodes and smaller numbers of cells were observed after experimental dental pulp infection with c. butyricum, suggesting that this bacterium induces cell death. apoptosis was evaluated ...	2005	15770029
portal vein thrombosis despite anticoagulation in a person with diabetes.		2005	15805557
towards a resolution on the inherent methodological weakness of the "effective number of codons used by a gene".	recently anders fuglsang provided a modified way for calculating n(c) when biased discrepancy is present in a gene [biochem. biophys. res. commun. 317 (2004) 957]. instead of taking the average codon homozygosity for each synonymous family type (as proposed by wright) [gene 87 (1990) 23] fuglsang considered codon homozygosity of each amino acid individually. marsashi and najafabadi [biochem. biophys. res. commun. 324 (2004) 1] in their recent article demonstrated that the readjustment for overes ...	2005	15823544
differences in prevalence of selected bacterial species in primary endodontic infections from two distinct geographic locations.	this study intended to compare the prevalence of 7 putative endodontic pathogens in samples of primary endodontic infections taken from patients of 2 distant geographic locations.	2005	15829891
dna probe identification of bacteria colonizing internal surfaces of the implant-abutment interface: a preliminary study.	currently, there is limited knowledge concerning the specific genus and species of bacteria that may colonize internal surfaces of the implant-abutment interface (iai) of two-stage dental implants. the purpose of this study was to use dna probe analysis to identify those periodontopathic bacteria that may inhabit the internal surfaces and healing abutment screw-threads of the iai of dental implants in situ.	2005	15830645
association of a novel high molecular weight, serine-rich protein (srpa) with fibril-mediated adhesion of the oral biofilm bacterium streptococcus cristatus.	the surface of the oral plaque bacterium streptococcus cristatus is decorated with a lateral tuft of fibrils. the fibrillar tuft functions in the adhesion of s. cristatus to heterologous bacterial species in the plaque biofilm. the tuft typically consists of a densely packed fringe of shorter fibrils 238 +/- 19 nm long with longer, less abundant fibrils 403 +/- 66 nm long projecting through the fringe of short fibrils. the two types of fibrils in the tufts of s. cristatus have been refractory to ...	2005	15836513
effect of khat chewing on 14 selected periodontal bacteria in sub- and supragingival plaque of a young male population.	the habit of chewing khat (catha edulis) for its amphetamine-like effects is highly prevalent in yemen and east africa, and has expanded to western countries. the purpose of this study was to estimate and compare the prevalence and levels of 14 periodontal bacteria in gingival plaque of khat chewers and khat nonchewers, as well as of khat chewing sides and khat nonchewing sides.	2005	15836514
detection of heat shock proteins but not superantigen by isolated oral bacteria from patients with behcet's disease.	we isolated bacteria from periodontal sites and mixed saliva in eight patients with behcet's disease and surveyed them to determine whether they produced heat shock proteins (hsps) and superantigen. cultivable bacterial compositions from periodontal sites and saliva were examined by anaerobic culture using blood agar plates. gram-negative anaerobic rods such as prevotella intermedia, fusobacterium nucleatum, and capnocytophaga species were predominant in the isolates from the subgingival plaque ...	2005	15836518
treponema medium glycoconjugate inhibits activation of human gingival fibroblasts stimulated with phenol-water extracts of periodontopathic bacteria.	oral treponemes are well-known as causative agents of periodontal diseases; however, the details have not been fully clarified. here, we examined the effects of treponema medium glycoconjugate on the activation of human gingival fibroblasts using phenol-water extracts from porphyromonas gingivalis, prevotella intermedia, fusobacterium nucleatum subsp. nucleatum, and actinobacillus actinomycetemcomitans. the phenol-water extracts activated human gingival fibroblasts to mediate il-8 production, as ...	2005	15840783
oral microbiology and genomics.		2005	15853937
failed dental implants - clinical, radiological and bacteriological findings in 17 patients.	the aim of this study was to evaluate the reasons for implant failure in two oral and maxillofacial units in helsinki. seventeen patients, who lost 30 implants were included in this study.	2005	15878525
tobacco smoking and periodontal microflora in a saudi arabian population.	to explore the subgingival periodontal microflora in a saudi arabian population with a special focus on its relationship with various smoking habits.	2005	15882210
susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and ll37, produced by human epithelial cells.	antimicrobial peptides are one of the factors involved in innate immunity. the susceptibility of periodontopathogenic and cariogenic bacteria to the major antimicrobial peptides produced by epithelia was investigated.	2005	15886266
microbial changes in conjunctival flora with 30-day continuous-wear silicone hydrogel contact lenses.	to determine the effect of 30-day continuous-wear silicone hydrogel contact lenses on the conjunctival flora in asymptomatic wearers.	2005	15894879
identification of cultivable microorganisms from primary endodontic infections with exposed and unexposed pulp space.	this study was aimed at comparing the cultivable microorganisms in canals with periapical radiolucencies with exposed and unexposed pulp space. microbiological samples were taken and analyzed from 45 canals with exposed pulp space, and 43 canals with unexposed pulp space. the canal contents were analyzed by aerobic/anaerobic culture, and conventional identification techniques. there were 211 isolates of bacteria belonging to 28 genera and 55 species recovered from exposed canals. in the unexpose ...	2005	15917680
molecular identification of an invasive gingival bacterial community.	a woman with neutropenia developed gingival hyperplasia. biopsy showed invasion of gingival tissue with mats of filamentous organisms, and molecular analysis by polymerase chain reaction and fluorescence in situ hybridization revealed capnocytophaga sputigena, leptotrichia species, and fusobacterium nucleatum. oral bacterial flora may cause invasive gingival disease with hyperplasia in immunocompromised patients.	2005	15937752
antimicrobial susceptibility variation of 50 anaerobic periopathogens in aggressive periodontitis: an interindividual variability study.	the frequent use of antibiotics in developed countries has led to the emergence of widespread bacterial resistance. in this study, the interindividual variability of the antibiotic susceptibility of 50 putative microorganisms in aggressive periodontitis patients has been evaluated by means of vc (variation coefficient).	2005	15943770
microarrays complement culture methods for identification of bacteria in endodontic infections.	the aim of this study was to investigate the microbial composition of necrotic root canals using culture methods and microarray technology. twenty uniradicular teeth with radiographic evidence of periapical bone loss and with no previous endodontic treatment were selected for this study. for molecular diagnosis a dna chip with 20 different species-specific, 16s-rdna-directed catcher probes was used. the microorganisms most frequently detected by the dna chip were: micromonas micros, fusobacteriu ...	2005	15943771
fiber optic fluorescence microprobe for endodontic diagnosis.	successful endodontic therapy requires total debridement as well as complete obturation of the root canal to the cemento-dentinal junction. the goal of this study was to investigate the feasibility of using quantitative fluorescence spectroscopy for the detection and localization of pathological dentin, pulpal remnants, and microorganisms within the root canal. specific aims were to identify: 1) characteristic excitation/emission spectra for healthy dentin, decayed dentin, enamel, and pulp; 2) t ...	2005	15947209
multi-target antimicrobial actions of zinc against oral anaerobes.	zinc is used in oral care products as an antiplaque/antigingivitis agent. our objective was to assess the antimicrobial actions of zinc against oral anaerobes associated with gingivitis, specifically fusobacterium nucleatum and prevotella intermedia, with focus on catabolism and oxidative metabolism.	2005	15958206
mechanism of visible light phototoxicity on porphyromonas gingivalis and fusobacterium nucleatum.	phototoxicity of visible light laser on the porphyrin-producing bacteria, porphyromonas gingivalis, in the absence of photosensitizers and under aerobic conditions was shown in previous studies. recently, we found that the noncoherent visible light sources at wavelengths of 400-500 nm, commonly used in restorative dentistry, induced a phototoxic effect on p. gingivalis, as well as on fusobacterium nucleatum, and to a lesser extent on the streptococci sp. to elucidate the mechanism of this photot ...	2005	15960594
comparison of culture and real-time pcr for detection and quantification of five putative periodontopathogenic bacteria in subgingival plaque samples.	bacterial cultivation is a well-established method for analyzing plaque samples. real-time polymerase chain reaction (pcr) is a novel rapid method for the identification and quantification of periodontopathogenic bacteria that has been recently introduced. in this study, we compared real-time pcr with conventional anaerobic cultivation.	2005	15966886
prevalence of periodontopathic bacteria in aggressive periodontitis patients in a chilean population.	actinobacillus actinomycetemcomitans is considered a major etiologic agent of aggressive periodontitis (agp). other periodontopathic bacteria such as porphyromonas gingivalis are also suspected of participating in aggressive periodontitis although the evidence to support this is controversial. the aim of the present study was to determine the prevalence of eight periodontopathic bacteria in chilean patients with agp.	2005	15974855
fluorescence based measurements of fusobacterium nucleatum coaggregation and of fusobacterial attachment to mammalian cells.	fusobacterium nucleatum is a common oral anaerobe associated with gingivitis, periodontal disease and preterm deliveries. coaggregation among oral bacteria is considered to be a significant factor in dental plaque development. adhesion to host cells was suggested to be important for the f. nucleatum virulence associated with oral inflammation and with preterm births. an uncharacterized fusobacterial galactose inhibitible adhesin mediates coaggregation of f. nucleatum 12230 and f. nucleatum pk159 ...	2005	15993010
protein secretion systems in fusobacterium nucleatum: genomic identification of type 4 piliation and complete type v pathways brings new insight into mechanisms of pathogenesis.	recent genomic analyses of the two sequenced strains f. nucleatum subsp. nucleatum atcc 25586 and f. nucleatum subsp. vincentii atcc 49256 suggested that the major protein secretion systems were absent. however, such a paucity of protein secretion systems is incongruous with f. nucleatum pathogenesis. moreover, the presence of one or more such systems has been described for every other gram-negative organism sequenced to date. in this investigation, the question of protein secretion in f. nuclea ...	2005	15993836
an antibacterial surface on dental implants, based on the photocatalytic bactericidal effect.	it is well known that the moderately roughened surfaces of dental implants enhance direct bone-implant contact. however, rough implant surfaces, as compared to smooth surfaces, are thought to pose a higher risk of bacterial infection when exposed to the oral cavity.	2005	15996357
antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in the netherlands and spain.	antimicrobial resistance of periodontal pathogens towards currently used antibiotics in periodontics has been investigated in a previous study. microbial resistance in the periodontal microflora was more frequently observed in spanish patients in comparison with dutch patients. the aim of the present study was to compare antimicrobial susceptibility profiles of five periodontal bacteria isolated from periodontitis patients in spain and in the netherlands.	2005	15998275
efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model.	current research aims to find alternatives to conventional methods for suppressing periodontopathogenic bacteria. photodynamic therapy (pdt) could be a suitable treatment procedure of periodontal infections.	2005	16018752
identification and characterization of a novel adhesin unique to oral fusobacteria.	fusobacterium nucleatum is a gram-negative anaerobe that is prevalent in periodontal disease and infections of different parts of the body. the organism has remarkable adherence properties, binding to partners ranging from eukaryotic and prokaryotic cells to extracellular macromolecules. understanding its adherence is important for understanding the pathogenesis of f. nucleatum. in this study, a novel adhesin, fada (fusobacterium adhesin a), was demonstrated to bind to the surface proteins of th ...	2005	16030227
vertebral osteomyelitis due to fusobacterium species: report of three cases and review of the literature.	we describe three cases of fusobacterium spp. diskitis and review with attention to risk factors, clinical features, diagnosis, treatment and outcome. in most of the reported cases, a ear-nose-throat infection was found. clinical manifestations were similar to those of classic bacterial vertebral osteomyelitis. clindamycin is the most appropriate antibiotic. the outcome seems to be very good without relapse with appropriate treatment compared to pyogenic vertebral osteomyelitis.	2005	16038751
fusobacterium nucleatum apoptosis-inducing outer membrane protein.	the periodontal pathogen fusobacterium nucleatum induces apoptosis in lymphocytes. we previously identified the autotransporter protein fap2 in f. nucleatum strain pk1594 that induced apoptosis in lymphocytes when expressed in escherichia coli. in this study, we identified protein homologs of fap2 in the transformable f. nucleatum strain atcc 23726, to determine their role in the induction of apoptosis in lymphocytes. we used a new gene-inactivation vector conferring thiamphenicol resistance (ph ...	2005	16040725
[efficacy variation of erythromycin and spiramycin on periopathogens in aggressive periodontitis. an in vitro comparative study].	erythromycin (ery) and spiramycin (spi) are the most frequently prescribed macrolides by dentists. however, the emergence of resistant anaerobic subgingival bacteria imposes an increased vigilance. this study aims to compare these macrolides efficacy on principal periopathogens.	2005	16087299