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selective effects of ect on hypothalamic-pituitary activity.the hypothesis that ect produces selective effects on hypothalamic-pituitary activity was investigated by determining the effect of ect on pituitary hormone release in nine depressed patients. after ect there were massive and rapid increases in the plasma concentrations of nicotine- and oestrogen-stimulated neurophysin (nsn and esn), prolactin (prl) and adrenocorticotropin (acth), smaller increases in plasma luteinizing hormone (lh) and cortisol, a significant decrease in plasma growth hormone ( ...20103037582
[studies on attenuation of cardiovascular responses during endotracheal intubation following rapid-sequence induction of anesthesia]. 20102976320
[in vitro development of blastema cells in axolotl limb regeneration: effect of insulin and nerve extracts on cellular proliferation].for the purpose of investigating the nature of the nervous factor which controls cell proliferation in limb blastema of newts, we have cultured primary mesenchymous cells from limb blastemas of axolotl. the cultures were carried out in petri dishes (primaria, falcon) with a basal medium with contained diluted mem supplemented with hormones (insulin, somatotropin, hydrocortisone and thyroxine). in this medium, the cells disperse from the explant from the 4th day of culture and begin to divide fro ...20102952210
[a new procedure for the biological denitrification of ground water]. 20102950354
use of laboratories owned by nonphysicians. 20104407829
[regional differences in the use of cholecystectomy in denmark during the period 1977-1985].in a register-based study of all cholecystectomized patients in denmark during the period from 1977-85 (37,048 patients) an account is given of the regional variations observed in connection with the intervention. the cholecystectomy operation is sub-divided into four types of operation dependent on whether the intervention is merely a matter of cholecystectomy or it involves the choledocus, the duodenum, the small intestine or other organs. the variation analysis is based on a division of the c ...20102919465
paradoxical effect of respiration on ventricular rate in atrial fibrillation.1. in 50 subjects with atrial fibrillation we have attempted to demonstrate variation of ventricular rate with respiration, as evidence of cardioregulatory reflex activity. 2. the electrocardiogram was recorded for 3 min during spontaneous respiration. the presence of respiratory variation of r-r intervals was analysed by multiple regression against a cosine function (cosinor analysis), making it possible to determine the phase of respiration when the intervals were longest. 3. variation in vent ...20102920528
the role of immunoglobulin e receptors in allergic diseases.recent studies presented evidence that subpopulations of lymphocytes, monocytes and eosinophils carry immunoglobulin (ige)-specific membrane receptors which differ from the classical fc epsilon-receptors on basophil granulocytes and mast cells. the analysis of ige-receptor interactions with various cells has led to important insights as to the requirements of ige-antibody regulations. in addition, the membrane biochemical mechanisms in the induction of mediator release became better understood. ...20102937412
[the behavior of 1,4-benzodiazepine drugs in acidic media. ix. effect of hydrolyzate of flutazolam on the central nervous system]. 20102894449
diurnal variations in pain perception and thermal sensitivity.pain and thermal sensitivity thresholds in healthy volunteers were examined for diurnal variations. the subjects were 11 men aged between 22 and 27 years (means = 23.5, s.d. = 1.5). data were collected for 2 days, with 7 measurements per day. to ensure the pain specificity of the results the subliminal modality, i.e., thermal sensitivity thresholds to warm and cold stimuli, was investigated in addition to the threshold for perception of heat pain. assessments were made on the right hand and foot ...20102919090
aids estimates. 20102916352
neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report.we measured the concentration of neuron-specific enolase (nse) and carcinoembryonic antigen (cea) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (sclc). high levels (above 12.5 micrograms.l-1) of nse in pleural fluid were observed in five patients with sclc (sensitivity 71%). however, pleural fluid nse levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammat ...20102853080
transfer of pre-embryos donated and fertilized in vivo to recipients given a steroid replacement therapy.this study describes eleven procedures of non-surgical recovery of preimplantation conceptuses from the uteri of eight fertile donor women and the transfer of the recovered pre-embryos into the uteri of infertile recipients with primary ovarian failure, or with hypothalamic--pituitary failure. conjugated oestrogens and progesterone were administered to recipients as replacement steroids during the first 20 weeks of pregnancy, in order to produce a secretory endometrium allowing nidation and deve ...20102851614
[bundle nailing--an evaluation after 27 years].the development of modern osteosynthetic procedures has made the use of bundle nailing uncommon. bundle nailing is restricted to extraordinary situations, but when indication is correct, it is superior to alternative procedures. from a current viewpoint only two indications remain: one are the fractures of the humeral shaft which cannot be treated conservatively, and the second are fractures of the femur in children if serious complications endanger conservative treatment. simple instruments and ...20102900592
metastasis of an occult gastric carcinoma suggesting growth of a prolactinoma during bromocriptine therapy: a case report with a review of the literature.the treatment of a slowly growing invasive prolactinoma with bromocriptine for 8 months resulted in a substantial decrease in plasma prolactin levels despite rapid suprasellar tumor expansion. on exploration, this uncommon observation could be attributed to hematogenous metastasis from an occult gastric adenocarcinoma to the pituitary tumor. apart from infiltration of neighboring parts of the hypothalamus, autopsy revealed no other hematogenous metastases. this extraordinary type of neoplasm-to- ...20102989726
snake bite in pregnancy. 20102863717
liposomes as membrane model for study of lipid peroxidation.this article describes the properties, production and characterization of liposomes with special reference to their use as membrane model for the study of lipid peroxidation. it presents briefly the methods that can be used for the assay of liposomal lipid peroxidation and brings out the special advantages these liposomes provide in elucidating the mechanism of lipid peroxidation by different physical and chemical agents. studies involving liposomal lipid peroxidation by different agents and the ...20102830175
generation of electronically excited species during enzymatic oxidation of chlorpromazine and related compound.chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at ph7.5 (but not at ph4.25) or of propericiazine, both at ph7.5 and at ph4.25. red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used. chemiluminescence was also detected at ph7.5, but not at ph4.25, when synthesized cation radical of chlorpromazine in water was mixed with concentrated buffer. protonation of alkyl nitrogen in the cation radical o ...20102862870
sodium absorption. 20102830324
[professionals in health areas: knowledge of the documentation terminology]. 20103249908
[effect of thymosin on afferent transmission in the somatosensory system of macaca rhesus]. 20103030681
[effect of thymosin on afferent transmission in the somatosensory system of macaca rhesus]. 20103030681
[sanitary education and its effect on the effectiveness of tuberculosis control]. 20102957687
why does placebo improve severe limb ischaemia? 20102893161
[aromatic plants in food: criteria for evaluation of their safety in use]. 20103675890
[aromatic plants in food: criteria for evaluation of their safety in use]. 20103675890
phospholipid metabolism and stimulus-response coupling. 20103030324
phospholipid metabolism and stimulus-response coupling. 20103030324
[clinical and hemodynamic effects of lipo pge1 in cerebral infarction].prostaglandin (pg) e1 is a potent vasodilator on the peripheral vessels and also has an inhibitory action of platelet aggregation. lipo pge1, the lipid emulsified pge1 has much longer half life time in the circulation than pge1 which is rapidly inactivated in the lung. the purpose of this investigation was to study the clinical and hemodynamic effect of lipo pge1 on the 15 patients with acute or subacute focal cerebral ischemia. of these patients, five had evidence of internal carotid artery occ ...20103221965
consent to aids testing. 20102901644
continuous positive airways pressure in respiratory-distress syndrome. 20104107416
hypomagnesemia in digitalized patients. 20103954538
malignant fibrous histiocytoma in keratosis, ichthyosis, and deafness syndrome. 20102849613
malignant hyperthermia and the dental practitioner. 20102952234
[current trends in the development of the science of coagulation abroad]. 20102996966
practical importance of immunostaining paraffin-embedded biopsy samples of small lymphocytic and follicle centre cell lymphomas for s100 protein. 20102863627
inguinal hernia pain. a cause. 20102794900
reticulocyte numbers in japanese quail chicks.erythrocyte parameters in coturnix coturnix japonica were evaluated daily during the first 2 weeks after hatching. nadirs in total circulating erythrocyte numbers, hematocrit percentages, and hemoglobin concentrations were found during the first 5 days posthatch. reticulocytosis from 4 to 9 days posthatch ameliorated these nadirs until 12 days posthatch, when secondary nadirs appeared. erythropoiesis was indicated by reticulocytosis when hemoglobin levels decreased. reticulocyte maturation was i ...20102881700
[that's what i remember best: night shift 4 weeks on end]. 20103551170
[that's what i remember best: night shift 4 weeks on end]. 20103551170
cloxacillin-induced neutropenia. 20103722871
the adenosine triphosphate-pyrophosphate isotopic exchange reaction: a tool for determination of tryptophan.quantitative determination of tryptophan at the picomole level is described, using the atp-[32p]ppi isotopic exchange reaction catalyzed by tryptophanyl-trna synthetase. sensitivity limits of 500 fmol were obtained. the presence of other amino acids at a 1000-fold excess over tryptophan did not interfere significantly with the quantitative determination of tryptophan. the specificity of the reaction was checked using five tryptophan analogs. these analogs did not prevent the determination of try ...20103014918
anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine b lymphocytes.protein phosphorylations are rapidly induced in intact b cells by antibodies to surface immunoglobulin (anti-igm) and by phorbol 12-myristate 13-acetate (pma). a comparison of the molecular weight, isoelectric points, phosphopeptides, and phosphoamino acids of the phosphoproteins induced by anti-igm and by pma suggests that anti-igm acts through the activation of protein kinase c. this conclusion is strengthened by the observation that prolonged treatment with pma ablates the ability of anti-igm ...20103021753
anti-immunoglobulin and phorbol ester induce phosphorylation of proteins associated with the plasma membrane and cytoskeleton in murine b lymphocytes.protein phosphorylations are rapidly induced in intact b cells by antibodies to surface immunoglobulin (anti-igm) and by phorbol 12-myristate 13-acetate (pma). a comparison of the molecular weight, isoelectric points, phosphopeptides, and phosphoamino acids of the phosphoproteins induced by anti-igm and by pma suggests that anti-igm acts through the activation of protein kinase c. this conclusion is strengthened by the observation that prolonged treatment with pma ablates the ability of anti-igm ...20103021753
interest of the dosage of the h.c.g. in the spermatical blood at the moment of the castration for a testicular tumor (about 28 cases 1978-1984). 20103008177
epidemiology of borderline ovarian tumors.ovarian tumors of low malignant potential, often termed "borderline tumors," have been defined as those that have some but not all of the morphologic features of malignancy (i.e., they are not invasive). with the use of data obtained by the western washington population-based cancer surveillance system for 1975-83, the incidence of serous and mucinous borderline epithelial ovarian tumors was analyzed, as well as the survival of women who developed them. the incidence of borderline tumors increas ...20103025504
epidemiology of borderline ovarian tumors.ovarian tumors of low malignant potential, often termed "borderline tumors," have been defined as those that have some but not all of the morphologic features of malignancy (i.e., they are not invasive). with the use of data obtained by the western washington population-based cancer surveillance system for 1975-83, the incidence of serous and mucinous borderline epithelial ovarian tumors was analyzed, as well as the survival of women who developed them. the incidence of borderline tumors increas ...20103025504
[role of laparoscopic examination in the diagnosis and control of treatment results in early and less advanced forms of endometriosis]. 20102956633
[computed tomographic determination of thyroid iodine concentration in an endemic goiter area].we determined the ct density of the thyroid gland in 60 patients with normal thyroids and 176 patients with various thyroid disorders. the density was 75 +/- 6.2 h.u. in normal thyroids, which was markedly higher than in goiters (66 +/- 6.0 h.u.), while there was a considerable further decrease in patients with immunogenic hyperthyroidism, the density being 48.5 +/- 7.9 h.u. the thyroids of patients with nonimmunogenic hyperthyroidism differed from these by virtue of a significantly greater dens ...20103008254
brain beta-endorphin and spinal-cord enkephalin concentrations in experimental arachnoiditis.arachnoiditis was produced experimentally in male albino icr mice by intrathecal injection of meglumine iocarmate . a control group received intrathecal injection of an electrolyte solution resembling csf. eight weeks after injection, the brains and spinal cords were removed for brain beta-endorphin and spinal cord met-enkephalin measurement by radioimmunoassay, and the dural sacs were removed for histologic examination to confirm the presence or absence of arachnoiditis. brain beta-endorphin co ...20102951348
relationship among function, phenotype, and specificity in primary allospecific t cell populations: identification of phenotypically identical but functionally distinct primary t cell subsets that differ in their recognition of mhc class i and class ii allodeterminants.the goal of the present study was to evaluate the relationship among function, lyt phenotype, and mhc recognition specificity in primary allospecific t cell populations. by using lyt-2+ and l3t4+ t cells obtained from the same responder populations, we assessed the ability of t cells of each phenotype to generate cytotoxic effector cells (ctl) and il 2-secreting helper t cells in response to either class i or class ii mhc allodeterminants. it was found that a discordance between lyt phenotype an ...20102946773
percutaneous transluminal angioplasty improves blood pressure and renal function in renovascular hypertension.thirty-three patients with renal angiographic evidence of significant renal artery stenosis were referred for percutaneous transluminal angioplasty. the indications were poorly controlled hypertension (n = 13) or hypertension associated with deteriorating renal function (n = 20). their mean age was 56 (23-73) years (12 males, 21 females). causes of the renal artery stenosis were fibromuscular dysplasia (n = 8) and atheromatous changes (n = 25). four patients were excluded, three due to technical ...20102958895
surgical streams in the flow of health care financing. the role of surgery in national expenditures: what costs are controllable?the dollar flow in united states medical care has been analyzed in terms of a six-level model; this model and the gross 1981 flow data are set forth. of the estimated $310 billion expended in 1981, it is estimated that $85-$95 billion was the "surgical stream", i.e., that amount expended to take care of surgical patients at a variety of institutional types and including ambulatory care and surgeons' fees. some of the determinants of surgical flow are reviewed as well as controllable costs and ca ...20103918514
chronic renal disease and hyperparathyroidism: dental manifestations and management. 20102963695
[treatment of chronic renal failure with traditional chinese medicine. follow-up of 90 cases]. 20102947714
abnormal degradation of erythrocyte membrane proteins in down's syndrome. 20102953697
[changes in metabolic control after interruption of oral hypoglycemic agents in type ii diabetic patients with secondary failure during combined therapy]. 20102976347
[experimental study of oral administration of streptococcal preparation "ok-432". the 6th report: its effect on in vivo anti-tumor immunity of the mice with transplanted cecal tumor]. 20102932509
calcific shoulder periarthritis (tendinitis) in adult onset diabetes mellitus: a controlled study.two groups, one of 824 adult diabetics and one of 320 age and sex matched non-diabetics, were examined for abnormal glucose metabolism and calcifications on anteroposterior shoulder x rays. two hundred and sixty two (31.8%) of the diabetics had shoulder calcification compared with 33 (10.3%) of the control group, with a preponderant localisation in the right shoulder. diabetes of long duration treated with insulin for a long time was associated with a larger percentage of shoulder calcifications ...20102930276
right atrial cardioplegia: a safe procedure for myocardial protection. 20102919927
[fibrinolytic therapy of thromboembolic vascular occlusions: experiences based on 87 patients]. 20102974192
[immunologic functions of kupffer cells]. 20102937390
ciprostene in patients with peripheral vascular disease (pvd). an open-label, tolerance trial.epoprostenol (prostacyclin) has been studied with various success in patients with peripheral vascular disease (pvd). we investigated the tolerance of a new, stable prostacyclin derivative ciprostene (9-beta-methyl carbacyclin) in 9 pvd patients. the drug was infused intravenously for 8 hours a day, once a week for 4 consecutive weeks, at a dose of 120 ng/kg/min. there were 6 men and 3 women with a mean age of 63 years (42-78). the pvd was verified by arteriography (9 patients) and by clinical f ...20103068680
cocaine--the deadliest addiction. 20102911405
[genetic counseling in ornithine carbamoyltransferase deficiency].ornithine transcarbamylase (otc) deficiency is an inborn error of urea cycle metabolism, responsible for lethal hyperammonemia in males and for severe symptoms in at least 20% of heterozygous females. the authors provide here additional data on the informativity of the protein loading test (plt) for the detection of heterozygotes. they show that the risk of being a carrier for the mother of an affected boy falls from 2/3 a priori to only 1/8 if her plt is negative. the risk for the mother of het ...20102903704
sex therapy for the penile prosthesis recipient.in conclusion, the evidence for technical success of the penile prosthesis is clear, but more detailed follow-up studies suggest that a large minority of patients and partners fail to achieve sexual satisfaction. if the goal of surgery is to restore sexual frequency, variety, and pleasure to optimal levels, an integrated treatment program that incorporates sex therapy may be more successful than implantation alone. the type of sex therapy required depends on the risk factors present for postsurg ...20102916282
carrier detection of haemophilia a using dna markers in families with an isolated affected male.the carrier status of women in five families with an isolated haemophilia male was assessed by pedigree analysis, coagulation factor assays and dna markers. in three families, ten women could be given very low risks of being carriers based on dna analysis. in two of the families the dna markers identified the mutation as originating in either the maternal or maternal grandfather's germ cell. combined dna and coagulation data suggested that the affected male in a third family was a de novo mutati ...20102887317
clinical experience with controlled expansion cylinders. the ams 700 cx inflatable penile prosthesis.device manufacturers continue to look for modifications in design to achieve specific objectives directed at improving overall reliability. changes in design that do not address this extremely significant concern, namely, device reliability, fail in their commitment toward improvement in patient satisfaction. one of the most effective ways to assess the benefits provided by any change in device design is through the clinical trial and study group method, utilizing a large number of implanting su ...20102916279
the artificial sphincter (as-800). experience in children and young adults.from reviewing our experience in the application of the as-800 sphincter for the management of incontinence in children, we conclude that implantation is indicated after conservative and less invasive therapy has been attempted. the bladder neck is the site of choice for cuff placement in children. primary deactivation and moderate or low reservoir pressures (61 to 70 and 71 to 80 cm h2o) are indicated, especially in patients with previous bladder neck surgery or an inadvertent bladder neck inju ...20102916269
coexistence of egg-laying hormone and alpha-bag cell peptide in bag cell neurons of aplysia indicates that they are a peptidergic multitransmitter system.double-label immunocytochemistry reveals that immunoreactivity for two putative peptide transmitters, egg-laying hormone and alpha-bag cell peptide, co-exist in most bag cell somata and processes in the abdominal ganglion of the marine mollusc aplysia. together with previous physiological and biochemical data these findings indicate that the neuroendocrine bag cells are a multitransmitter system which utilizes two or more peptides derived from a common precursor.20102877421
antagonism of vecuronium and atracurium: comparison of neostigmine and edrophonium administered at 5% twitch height recovery.in 39 healthy patients antagonism, by neostigmine 0.07 mg kg-1 or edrophonium 0.8 mg kg-1, of neuromuscular blockade induced by vecuronium or atracurium, was compared. reversal was attempted when the height of the single twitch (th) had recovered spontaneously to 5% of the control value. the evoked responses, initially single twitch, then train-of-four (tof) were observed until the tof ratio was 70%. induced recovery from th 5% to 25% was shorter following edrophonium than following neostigmine ...20102882769
chemotactic function of polymorphonuclear leukocytes from patients with recurrent infections: partial correction by levamisole "in vitro".polymorphonuclear leukocytes are dominant cells in the defense of the organism, and their functional alterations result in increased risks of infection. chemotaxis is an early function in the immune response, allowing for the polymorphonuclear cells to migrate towards inflammatory sites. we studied the chemotactic function of the polymorphonuclear leukocytes from 14 patients with the common clinical syndrome of recurrent infections, through a technique of cell migration under agarose. it was fou ...20104003229
magnetic resonance imaging and early diagnosis of multiple sclerosis. 20102903418
blood coagulability and viper envenomation. 20102869321
psychosocial and physiological factors in relation to blood pressure at rest--a study of swedish men in their upper twenties.the interrelationships between psychosocial factors, several physiological variables and blood pressure (bp) were investigated in 88 young men (aged 26-32 years) in whom high, intermediate or low bp had been recorded at the age of 18 years. in the original high bp group, venous plasma noradrenaline was normal but adrenaline levels elevated. at the follow-up adrenaline correlated with systolic blood pressure (sbp), and this was also so after controlling for overweight and serum gamma-glutamyltran ...20102868055
selective adrenergic beta-2-receptor blocking drug, ici-118.551, is effective in essential tremor.eighteen patients with essential tremor were treated for 2 days with a non-selective adrenergic beta-blocking drug (dl-propranolol, 80 mg x 3), a beta-2-selective blocker (ici-118.551, 50 mg x 3) and placebo (x 3) in a randomized double blind cross-over study. postural hand tremor was recorded with an accelerometer before administration of the drugs and at the end of each treatment period. compared with placebo, both the beta-blocking drugs caused a statistically significant decrease in tremor i ...20102876576
quantitative evaluation of leukemic mitochondria with a computer-controlled image analyzer.mitochondria from 25 patients with acute lymphoblastic leukemia (all) and 25 patients with acute myelogenous leukemia (aml) were compared in terms of their number, area, and shape index using a computer-controlled image analyzer. the number of mitochondria was greater in the aml than in the all patients. however, their size, as measured in electron micrographic profiles was similar in the two groups, in disagreement with conventional reports that mitochondria are small in granulocytes but large ...20102876544
[partial 21-hydroxylase deficiency: study of 5 cases]. 20102845201
exposure to benzodiazepines in utero. 20102884529
somatostatin analogue sms 201-995 in type i diabetes mellitus. initial experience after repeated administration.we have recently obtained encouraging short-term results after a single subcutaneous injection of the long-acting somatostatin analogue sms 201-995 in acromegalic patients. increased growth hormone (gh) levels may be involved in the pathogenesis of proliferative retinopathy in type i diabetes mellitus. in this study we thus investigated the effect of 3 x 50 micrograms sms 201-995 daily on the metabolic control and hormone secretion of eight type i diabetics over a 3-day period. gh levels decreas ...20102876502
the effects of a supratentorial mass lesion on brain-stem auditory evoked potentials and short latency somatosensory evoked potentials.nineteen patients with unilateral supratentorial mass lesion and without any evident clinical signs of transtentorial herniation were studied with computed tomography (ct), brain-stem evoked potentials (baeps) and central conduction time (cct) of short latency somatosensory evoked potentials (seps). sixteen had tumours, two had intracranial haematoma and one had chronic subdural haematoma. ct detected the initial signs of transtentorial herniation in every case. preoperative i-v interpeak latenc ...20102871503
opportunities for lay midwifery practice. 20102929822
pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failure.the antihypertensive efficacy and pharmacokinetics of a single 1 mg oral dose of doxazosin were investigated in five healthy male volunteers, six patients with renal failure not on hemodialysis, and four patients with end-stage renal failure studied between two hemodialyses. the dialyzability of doxazosin was studied in five patients. the maximum fall in blood pressure of both volunteers and patients occurred between 4 and 8 hours. in four of five volunteers the blood pressure had returned to ba ...20102945688
selective effects of enzyme treatment used for dissociating single cells on their gaba-receptor activities.frog dorsal root ganglion (drg) cells treated with collagenase and trypsin were dissociated mechanically. the characteristics of dose-response curves of gaba-induced cl- currents (icl) were mainly studied using the "concentration-clamp" technique, by which the external solution around isolated single neurons was rapidly changed within a few milliseconds. the saturating maximum currents induced by various concentrations of gaba normalized to the peak icl induced by 10(-5) m gaba on the same neuro ...20102829067
determination of pyrimidine 5'-nucleotidase (p5n) activity in whole blood as an index of lead exposure.a simple method for determining pyrimidine 5'-nucleotidase (p5n) activity in whole blood has been developed, inhibiting the plasma activity for ump-hydrolysis by concanavalin (con a). con a specifically inhibits the activity of plasma 5'-nucleotidase (5n) but does not affect erythrocyte p5n activity. the anticoagulant edta partially inhibits 5n activity but slightly activates p5n. p5n activity determined by the present method with heparinised blood and con a was comparable with that by the metho ...20102840110
cross-linking site in fibrinogen for alpha 2-plasmin inhibitor.a plasma proteinase inhibitor, alpha 2-plasmin inhibitor (alpha 2pi), is cross-linked with alpha chain of fibrin(ogen) by activated coagulation factor xiii (plasma transglutaminase). alpha 2pi serves only as a glutamine substrate (amine acceptor) for activated factor xiii in the cross-linking reaction, and the cross-linking occurs between gln-2 of the alpha 2pi molecule and a lysine residue (amine donor) of fibrin(ogen) alpha chain, whose position was investigated. alpha 2pi and fibrinogen were ...20102877981
[exorbitant responsibilities!]. 20102814197
the organization of the cholinergic synapse. 20102904504
peripheral neuropathy associated with mitochondrial myopathy.twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. there were clinical features of a mild sensorimotor neuropathy in five patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction compared with controls. sural nerve biopsy and morphometric studies were performed on four patients with clinical neuropathy. there wa ...20102849395
low-dose aspirin in pregnancy.in a prospective study, we evaluated the effects of low-dose aspirin on maternal and neonatal plasma 6-keto-prostaglandin (pg) f1 alpha concentration, platelet aggregation, platelet thromboxane production, and neonatal transitional circulation. forty women, at a mean (+/- sd) of 37 +/- 2 weeks' gestation, were randomized to receive (n = 10 each) placebo or 20, 60, or 80 mg of aspirin per day until delivery. maternal serum 6-keto-pgf1 alpha levels were not affected by these doses of aspirin, wher ...20102797631
prognostic and therapeutic observations of manifestations in the genitourinary tract of adenocarcinoma of the colon and rectum.to evaluate the significance of involvement of the genitourinary tract in adenocarcinoma of the colon and rectum, we received the records of 178 patients with adenocarcinoma of the colon and rectum admitted to the university of massachusetts medical center from 1980 to 1985. sixty-eight patients (38 per cent) had urologic manifestations categorized as ureteral obstruction or injury (34 per cent), invasion to the bladder or prostate, or both (10 per cent), isolated gross hematuria (18 per cent), ...20102814767
the complete nucleotide sequence of tetanus toxin. 20103774547
[pulmonary sarcoidosis with bullous development]. 20102966391
ceftriaxone resistant shigella flexneri, an emerging problem.shigellosis is a disease of public health importance in developing countries. it may cause self-limited diarrhea to severe dysentery. emergence of multi drug resistant (mdr) strains is a growing concern globally. ceftriaxone and ciprofloxacin are the drugs of choice for mdr cases. here, we report a case of mdr shigella flexneri from an immunocompromised patient. the strain was resistant to ceftriaxone [minimum inhibitory concentration (mic) ≥ 64 μg/ml], limiting the treatment option. simultaneou ...201021258157
notes from the field: emergence of shigella flexneri 2a resistant to ceftriaxone and ciprofloxacin --- south carolina, october 2010.on october 20, 2010, the south carolina department of health and environmental control and cdc began investigating a cluster of three diarrheal illnesses caused by multidrug-resistant shigella flexneri 2a. the index case occurred in a girl aged 2 years who experienced the onset of diarrhea on september 25 and was hospitalized the next day because of a seizure and fever. on september 30, her brother, aged 6 years, was hospitalized with vomiting, bloody diarrhea, and hyponatremia. three days later ...201021160457
[study on the integration site and arrangement of sfii and sfx prophages in shigella flexneri serotype 2b strains.]objective: to study the integration site and arrangement of sfii and sfx prophages in shigella flexneri serotype 2b strains. methods: a series of primers were designed based on potential integration site of sfii and sfx prophages in shigella flexneri serotype 2b strains, and pcr were performed for 50 serotype 2b strains to amplify special genes located in host and prophages. pcr products were sequenced to identify integration sites and arrangement of sfii and sfx. results: in all the serotype 2b ...201021162847
emergence of a novel shigella flexneri serotype 4s strain that evolved from a serotype x variant in china.this paper describes the first isolation of a new shigella flexneri serotype, designated 4s, in beijing, china. genotypic and phenotypic profiling suggests that this isolate is a clone of the s. flexneri serotype x variant reference strain. of particular concern is the multidrug resistance exhibited by this isolate.201021177890
cutting edge: nlrc5-dependent activation of the inflammasome.the nucleotide-binding domain leucine-rich repeat-containing proteins, nlrs, are intracellular sensors of pathogen-associated molecular patterns and damage-associated molecular patterns. a subgroup of nlrs can form inflammasome complexes, which facilitate the maturation of procaspase 1 to caspase 1, leading to il-1β and il-18 cleavage and secretion. nlrc5 is predominantly expressed in hematopoietic cells and has not been studied for inflammasome function. rna interference-mediated knockdown of n ...201021191067
microarray analysis of shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition.shigella flexneri inhibits apoptosis in infected epithelial cells. in order to understand the pro-survival effects induced by the bacteria, we utilized apoptosis-specific microarrays to analyze the changes in eukaryotic gene expression in both infected and uninfected cells in the presence and absence of staurosporine, a chemical inducer of the intrinsic pathway of apoptosis. the goal of this research was to identify host factors that contribute to apoptosis inhibition in infected cells.201020429941
modulation of shigella virulence in response to available oxygen in vivo.bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. here we show that shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (t3ss). the t3ss is essential for cell invasion and virulence. in anaerobic environments (for example, the gastrointestinal tract lumen), shigella is primed for invasion and expresses extended t ...201020436458
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