Publications

foodborne outbreak of gastroenteritis due to norovirus and vibrio parahaemolyticus.	vibrio parahaemolyticus and norovirus have been recognized as the cause of sporadic cases or outbreaks of diarrhoeal illness in association with the ingestion of raw or improperly cooked seafood. this report describes a foodborne outbreak of gastroenteritis caused by both norovirus and vibrio parahaemolyticus following the consumption of raw seafood in a restaurant in terrassa (catalonia, spain) in september 2005. measures are needed to reduce contamination of raw seafood. consumers can reduce t ...	2009	18667107
first molluscan tnf-alpha homologue of the tnf superfamily in disk abalone: molecular characterization and expression analysis.	tumor necrosis factor alpha (tnf-alpha) is considered as a multifunctional immune modulator that plays an important role in the innate and adaptive immune systems in vertebrates. here, we described the characterization and expression analysis of the first tnf-alpha homologue in mollusk abalone, named as abtnf-alpha. it has 930-bp full length with a 717-bp open reading frame (orf), encoding 239 amino acids. the abtnf-alpha amino acid sequence shows the characteristic tnf family signature, n-termi ...	2009	18984056
not without cause: vibrio parahaemolyticus induces acute autophagy and cell death.	vibrio parahaemolyticus (v. parahaemolyticus) is a gram-negative halophillic bacterium that causes worldwide seafood-borne gastroenteritis. the prevalence of v. parahaemolyticus in the environment and incidence of infection have been linked to rising water temperatures caused by global warming. among its virulence factors, v. parahaemolyticus harbors two type iii secretion systems (t3ss). recently, we have shown that t3ss1 induces rapid cellular death that initiates with acute autophagy, as meas ...	2009	19011375
reanalysis of structure/function correlations in the region of transmembrane segments 4 and 5 of the rabbit sodium/glucose cotransporter.	the predicted topology of the mammalian high-affinity sodium/glucose cotransporter (sglt1), in the region surrounding transmembrane segments 4 and 5, disagrees with the recent published crystal structure of bacterial sglt from vibrio parahaemolyticus (vsglt). to investigate this issue further, 38 residues from i143 to a180 in the n-terminal half of rabbit sglt1 were each replaced with cysteine and then expressed in cos-7 cells or xenopus laevis oocytes. the membrane orientations of the substitut ...	2009	19013429
transgenic microalgae as a non-antibiotic bactericide producer to defend against bacterial pathogen infection in the fish digestive tract.	antibiotics are commonly employed in most fish aquacultures to prevent disease. one major risk in this practice is that antibiotic-resistant pathogens may be selected. therefore, we wanted to examine the feasibility of producing an economical, non-antibiotic alternative. the microalga nannochloropsis oculata is an essential phytoplankton used as live feed for fish larvae. we attempted to culture n. oculata in a way that would provide an organism against bacterial pathogenic infection. to test th ...	2009	18691655
ampylation of rho gtpases by vibrio vops disrupts effector binding and downstream signaling.	the vibrio parahaemolyticus type iii effector vops is implicated in cell rounding and the collapse of the actin cytoskeleton by inhibiting rho guanosine triphosphatases (gtpases). we found that vops could act to covalently modify a conserved threonine residue on rho, rac, and cdc42 with adenosine 5'-monophosphate (amp). the resulting ampylation prevented the interaction of rho gtpases with downstream effectors, thereby inhibiting actin assembly in the infected cell. eukaryotic proteins were also ...	2009	19039103
innate immunity in the deep sea hydrothermal vent mussel bathymodiolus azoricus.	the interaction between microorganisms and host defense mechanisms is a decisive factor for the survival of marine bivalves. they rely on cell-mediated and humoral reactions to overcome the pathogens that naturally occur in the marine environment. in order to understand host defense reactions in animals inhabiting extreme environments we investigated some of the components from the immune system of the deep sea hydrothermal vent mussel bathymodiolus azoricus. cellular constituents in the hemolym ...	2009	19041413
molecular cloning and expression of myd88 in large yellow croaker, pseudosciaena crocea.	myeloid differentiation factor 88 (myd88) is an adaptor protein involved in the interleukin-1 receptor and toll-like receptor-induced activation of nuclear factor-kappab (nf-kappab). in this report, the full-length cdna of myd88 was cloned from the large yellow croaker, pseudosciaena crocea. it was of 1574 bp, including a 5'-terminal untranslated region (utr) of 89 bp, a 3'-terminal utr of 621bp and an open reading frame (orf) of 864 bp encoding a polypeptide of 287 amino acids. it contained a t ...	2009	19049879
cold-induced gene expression profiles of vibrio parahaemolyticus: a time-course analysis.	a whole-genome dna microarray was constructed to dissect expression profiles of vibrio parahaemolyticus in response to a sudden temperature downshift from 37 to 10 degrees c. the mrna level of each gene at each of three time points (20, 40 and 60 min after temperature downshift) was compared with that just before cold treatment. clustering analysis of time-course data revealed nine gene clusters with different time-dependent expression patterns. downregulation of metabolism-related genes was obv ...	2009	19054071
identification and characterization of a novel type iii secretion system in trh-positive vibrio parahaemolyticus strain th3996 reveal genetic lineage and diversity of pathogenic machinery beyond the species level.	vibrio parahaemolyticus is a bacterial pathogen causative of food-borne gastroenteritis. whole-genome sequencing of v. parahaemolyticus strain rimd2210633, which exhibits kanagawa phenomenon (kp), revealed the presence of two sets of the genes for the type iii secretion system (t3ss) on chromosomes 1 and 2, t3ss1 and t3ss2, respectively. although t3ss2 of the rimd2210633 strain is thought to be involved in human pathogenicity, i.e., enterotoxicity, the genes for t3ss2 have not been found in trh- ...	2009	19075025
morphological changes of vibrio parahaemolyticus under cold and starvation stresses.	this study addresses morphological changes of vibrio parahaemolyticus cells during the initial period of stress. drastic changes occurred in cells under starvation with/without concomitant cold treatment for one to a few days. under carbon starvation, rod-shaped cells became coccoid by reductive division, which was influenced by glucose/amino acid in the culture medium. under concomitant cold and carbon starvation, cells entered the viable but nonculturable state and their shape changed from rod ...	2009	19101053
enhancement of uv light sensitivity of a vibrio parahaemolyticus o3:k6 pandemic strain due to natural lysogenization by a telomeric phage.	the vibrio parahaemolyticus o3:k6 pandemic clonal strain was first observed in southern chile in 2004 and has since caused approximately 8,000 seafood-related diarrhea cases in this region. the massive proliferation of the original clonal population offers a unique opportunity to study the evolution of a bacterial pathogen in its natural environment by detection and characterization of emerging bacterial variants. here, we describe a group of pandemic variants characterized by the presence of a ...	2009	19151181
inactivation of mismatch repair increases the diversity of vibrio parahaemolyticus.	inactivation of mismatch repair (mmr) has been shown to increase the accumulation of spontaneous mutations and frequency of recombination for diverse pathogenic bacteria. currently, little is known regarding the role of mutator phenotypes for the diversification of natural populations of opportunistic human pathogens in marine environments. in this study, a higher frequency of mutators was detected among v. parahaemolyticus strains obtained from environmental sources compared with clinical sourc ...	2009	19161434
siderophore production by the marine-derived aureobasidium pullulans and its antimicrobial activity.	over 300 yeast strains isolated from different marine environments were screened for their ability to produce siderophore. among them, only the yeast strain hn6.2 which was identified to be aureobasidium pullulans was found to produce high level of the siderophore. under the optimal conditions, this yeast strain could produce 1.1mg/ml of the siderophore. the crude siderophore produced by the yeast strain hn6.2 was able to inhibit cell growth of vibrio anguillarum and vibrio parahaemolyticus, iso ...	2009	19162476
evaluation of a digoxigenin-labelled probe for detection of aeromonas spp.	an outer membrane protein-based digoxigenin (dig)-labelled dna probe was developed for the specific detection of aeromonas sp. from food/environmental/clinical samples. dot blot reaction answered for all the aeromonas isolates and was negative for escherichia coli, pseudomonas sp., klebsiella sp., vibrio parahaemolyticus, v. harveyi, v. alginolyticus, v. vulnificus. edwardsiella tarda and staphylococcus sp. as this protein is highly conserved in various aeromonas species, the probe has the poten ...	2009	19187505
epidemiology of vibrio parahaemolyticus outbreaks, southern chile.	disease outbreaks caused by vibrio parahaemolyticus in puerto montt, chile, began in 2004 and reached a peak in 2005 at 3,600 clinical cases. until 2006, every analyzed case was caused by the serovar o3:k6 pandemic strain. in the summer of 2007, only 475 cases were reported; 73% corresponded to the pandemic strain. this decrease was associated with a change in serotype of many pandemic isolates to o3:k59 and the emergence of new clinical strains. one of these strains, associated with 11% of the ...	2009	19193258
prevalence and potential pathogenicity of vibrio parahaemolyticus in chinese mitten crabs (eriocheir sinensis) harvested from the river thames estuary, england.	chinese mitten crabs (eriocheir sinensis) have been described as an alien invasive species in the river thames, united kingdom, and elsewhere in europe. the crabs can cause considerable physical damage to the riverbeds and threaten native ecosystems. trapping has been considered an option, but such attempts to control mitten crab populations in germany in the 1930s failed. in the united kingdom, it has been suggested that commercial exploitation of the species could be employed as a control opti ...	2009	19205465
evaluation of the compact dry vp method for screening raw seafood for total vibrio parahaemolyticus.	compact dry vp (cdvp) is a ready-to-use method for enumerating vibrio parahaemolyticus in food. the presterilized plates contain a culture medium comprising peptone, nacl, bile salts, antibiotics, chromogenic substrates, and polysaccharide gum as a cold water-soluble gelling. after diluting raw seafood samples in a phosphate-buffered saline solution, a 1-ml aliquot was inoculated onto the center of the plate and allowed to diffuse by capillary action. blue-green colonies forming on the plates we ...	2009	19205480
effects of flash freezing, followed by frozen storage, on reducing vibrio parahaemolyticus in pacific raw oysters (crassostrea gigas).	this study investigated the effects of flash freezing, followed by frozen storage, on reducing vibrio parahaemolyticus in pacific raw oysters. raw pacific oysters were inoculated with a five-strain cocktail of v. parahaemolyticus at a total level of approximately 3.5 x 10(5) most probable number (mpn) per gram. inoculated oysters were subjected to an ultralow flash-freezing process (-95.5 degrees c for 12 min) and stored at -10, -20, and -30 degrees c for 6 months. populations of v. parahaemolyt ...	2009	19205481
mg2+-free buffer elevates transformation efficiency of vibrio parahaemolyticus by electroporation.	the ability to transform vibrio spp. is limited by the extracellular nuclease that their cells secrete. the reported transformation efficiency of this organism is 10(2)-10(5) transformants per microgram dna. we tried different buffers and conditions, aiming to elevate its transformation efficiency.	2009	19207855
vibrio biofilms: so much the same yet so different.	vibrios are natural inhabitants of aquatic environments and form symbiotic or pathogenic relationships with eukaryotic hosts. recent studies reveal that the ability of vibrios to form biofilms (i.e. matrix-enclosed, surface-associated communities) depends upon specific structural genes (flagella, pili and exopolysaccharide biosynthesis) and regulatory processes (two-component regulators, quorum sensing and c-di-gmp signaling). here, we compare and contrast mechanisms and regulation of biofilm fo ...	2009	19231189
characterization of a phosphoenzyme intermediate in the reaction of phosphoglycolate phosphatase.	when 32p-glycolate and phosphoglycolate phosphatase from spinach are mixed, 32p is incorporated into acid precipitated protein. properties that relate the phosphorylation of the enzyme to the phosphatase are: the km value for p-glycolate is similar for protein phosphorylation and substrate hydrolysis; the 32p in the phosphoenzyme is diluted by unlabeled p-glycolate or the specific alternative substrate, ethyl-p; the activator cl- enhances the effectiveness of ethyl-p as a substrate and as an inh ...	2009	2820973
characterization of a phosphoenzyme intermediate in the reaction of phosphoglycolate phosphatase.	when 32p-glycolate and phosphoglycolate phosphatase from spinach are mixed, 32p is incorporated into acid precipitated protein. properties that relate the phosphorylation of the enzyme to the phosphatase are: the km value for p-glycolate is similar for protein phosphorylation and substrate hydrolysis; the 32p in the phosphoenzyme is diluted by unlabeled p-glycolate or the specific alternative substrate, ethyl-p; the activator cl- enhances the effectiveness of ethyl-p as a substrate and as an inh ...	2009	2820973
second meeting of the panamerican society for pigment cell research. bethesda, maryland, april 23-26, 1989. abstracts.		2009	2812206
second meeting of the panamerican society for pigment cell research. bethesda, maryland, april 23-26, 1989. abstracts.		2009	2812206
anomalous origin of right pulmonary artery from the ascending aorta.	anomalous origin of one pulmonary artery from the ascending aorta without associated intracardiac defects is a rare congenital malformation. about 60 anatomic and surgical descriptions have been reported in the literature. up to 1974, 22 of the 50 reported cases underwent surgical correction with a 40% mortality rate. the natural history without surgery is poor with a very high mortality during the first year of life. successful anatomic correction of anomalous origin of right pulmonary artery f ...	2009	2777879
the grading and prevalence of macular degeneration in chesapeake bay watermen.	a new grading scheme was developed to classify the fundus features of macular degeneration. this scheme identifies the earliest fundus changes associated with macular degeneration, as well as specific drusen characteristics felt to be associated with an increased risk of developing the exudative forms of this disease. agreement between two graders using this scheme indicated good interobserver reliability. using this scheme, fundus photographs of 777 participants were graded in a population-base ...	2009	2786408
treatment of nasal polyps--medication or surgery and which technique.		2009	2772493
predictors of mortality and physical disability in the charleston heart study.		2009	2741270
mass treatment approach to acute diarrhoeal disease in afabet hospital, northern ethiopia.	during an outbreak of acute diarrhoeal disease in a military camp in afabet region from august to october 1985, 416 cases were admitted to afabet hospital. all were national military service recruitee males who developed signs of moderate to severe dehydration. simplified methods of diagnosing and treating the disease were used so that mass rehydration therapy could be instituted early, using locally available manpower and material resources. the severity of dehydration was graded, and rehydrati ...	2009	2753031
an ultrastructural study of pigeon bursa of fabricius during involution.	the ultrastructure of the pigeon bursa of fabricius during involution is described. according to the aa, the involutive process may be divided into 3 stages: an early involutive stage, a late involutive stage and a residual stage. the involutive process starts from epithelium later affecting the follicular medulla and all other structures of the organ. a mucoid degeneration can be observed, followed by an impressive fatty degeneration.	2009	2817414
3 drug management problems: cost, confusion, and adverse reactions.		2009	2733864
hb j-calabria [beta 64(e8)gly----asp] found in a japanese family.		2009	2737915
[fibrinogen and pentoxifylline. results of a french cooperative exploratory study of stage ii arteritis].	a collaborative exploratory study was undertaken by 139 private angiologists in 427 out-patients with pvd stage ii treated for 90 days with pentoxifylline 1 200 mg per day. in 306 patients (71,6%) the fibrinogen level was decreased by 0,21 g/l in mean (p less than 0.01). this significant decrease is correlated to the global improvement (p less than 0.01) and is within the magnitude of difference that is associated between vascular death and comparative groups in recent epidemiologic studies. in ...	2009	2715734
brain resuscitation. medical management and innovations.	in this article, we have reviewed the pathophysiology and several therapeutic strategies for cerebral ischemia. it seems likely that there will never be simple therapeutic answers to the complex pathophysiology of cerebral ischemia as we now understand it. ultimate therapies will probably involve combinations of interventions designed to block several ongoing pathophysiologic processes in neuronal death. progress in this field will likely be slow and difficult.	2009	2679786
cinahl and medline: a comparison of indexing practices.	a random sample of fifty nursing articles indexed in both medline and cinahl (nursing & allied health) during 1986 was used for comparing indexing practices. indexing was analyzed by counting the number of major descriptors, the number of major and minor descriptors, the number of indexing access points, the number of common indexing access points, and the number and type of unique indexing access points. the study results indicate: there are few differences in the number of major descriptors us ...	2009	2676049
endoscopic sclerotherapy for esophago-gastric varices: a critical reappraisal.	amongst the many non-surgical techniques for the treatment of variceal bleeding, endoscopic sclerotherapy (est) has shown great promise. est can successfully obliterate esophageal varices and prevent variceal rebleeding. it is also very effective in the control of active bleeding from esophageal varices. the technique of est is simple and can be carried out with a conventional, forward viewing, flexible endoscope and a teflon injector. weekly intravariceal injections of an aqueous sclerosant are ...	2009	2669716
thrombolytic therapy. a review (2).		2009	2663220
links between clinical and experimental neuropsychology.	the goals of both experimental and clinical neuropsychology involve qualitative analyses of the behavioral sequelae of brain damage in humans. both of these subdisciplines attempt to delineate and clarify perceptual, cognitive, linguistic, affective, and other changes in individuals with neurological disease--particularly as these disorders contribute to our understanding of normal brain function and its modification by pathology. thus, an interest in brain-behavior relations is coupled with dia ...	2009	2668327
current concepts of the vestibular system reviewed: 1. the role of the vestibulospinal system in postural control.	this paper reviews the research findings that support the presence of vestibulospinal reflexes in corrections for head and body instability. studies of the importance of labyrinthine inputs to the central nervous system organization of eye, head, and body movements demonstrate that the vestibular nuclei are more than a simple relay station for labyrinthine activity. at all levels of the vestibular system beyond the primary vestibular afferents, parallel processing of labyrinthine signals occurs ...	2009	2655458
combination of behavioral smoking cessation with transdermal nicotine substitution.	effects of a transdermal nicotine substitution on psychological smoking cessation were investigated in a double-blind prospective study. 131 smokers were randomly assigned to three treatment conditions: all smokers underwent nine weeks of self-controlled smoking cessation. during six weeks one group was additionally treated with nicotine patches continuously releasing nicotine through the skin into the blood circuit. the second group received placebo patches; while the third group was treated wi ...	2009	2728961
high-frequency ventilation experience: a rescue protocol for neonates with airleaks.		2009	2681914
a randomized controlled trial of extra-amniotic ethinyloestradiol in ripening the cervix at term.	a double-blind randomized controlled trial investigated the use of extra-amniotic ethinyloestradiol for ripening the unfavourable cervix at term. twenty-five primigravidae were treated with 150 mg ethinyloestradiol gel while 24 primigravidae were treated with gel alone. there was no statistical difference between the ethinyloestradiol and control groups in either mean change in bishop score or the induction-to-delivery interval.	2009	2673340
evaluation of infant feeding in acute gastroenteritis.	sixty-eight bottle-fed babies under 9 months of age with mild acute gastroenteritis were observed to evaluate current feeding regimens following acute gastroenteritis in infancy. all babies were fed for 24 h with a glucose-electrolyte mixture (gem) and then randomly assigned to either a gradual reintroduction to their normal milk, i.e., slow regrade; immediate return to full-strength formula; or a rapid regrade to a hypoallergenic whey hydrolysate formula. all groups were well matched for age, s ...	2009	2709254
health care entrepreneur's key to success: break the mold.		2009	2921025
intrathecal baclofen for severe spinal spasticity.	we studied the effect of the intrathecal infusion of baclofen, an agonist of gamma-aminobutyric acid, on abnormal muscle tone and spasms associated with spinal spasticity, in a randomized double-blind crossover study. twenty patients with spinal spasticity caused by multiple sclerosis or spinal-cord injury who had had no response to treatment with oral baclofen received an intrathecal infusion of baclofen or saline for three days. the infusions were administered by means of a programmable pump i ...	2009	2657424
perceived distributions of the characteristics of in-group and out-group members: empirical evidence and a computer simulation.	this research studied 2 properties of perceived distributions of the characteristics of social category members: the probability of differentiating (making distinctions) among category members and the perceived variability (variance) of category members. the results of 4 experiments supported the hypothesis that greater familiarity with a social group leads to greater perceived differentiation and variability regarding that group. in-group members formed more differentiated and variable distribu ...	2009	2760805
[poisoning by geromitra esculenta].	gyromitra esculenta (persoon ex fries) mushrooms have been responsible for severe intoxications and even deaths. clinical data are characterized primarily by vomiting and diarrhoea, and, afterwhile, by jaundice, convulsions and coma. the species of concern are mainly g. esculenta, g. fastigiata and g. gigas; nevertheless, recent advances in chromatography, biochemistry and toxicology have established that other species within the ascomycetes may prove also toxic. the toxins, i.e. gyromitrin (n-m ...	2009	2681713
weakness in patients with hemiparesis.	clinical and experimental results are reviewed concerning muscle weakness in patients with hemiparesis after a stroke. the discussion includes the important role that alterations in the physiology of motor units, notably changes in firing rates and muscle fiber atrophy, play in the manifestation of muscle weakness. this role is compared with the lesser role that spasticity (defined as hyperactive stretch reflexes) of the antagonist muscle group appears to play in determining the weakness of agon ...	2009	2655457
the influence of type of tube and experience of the operator on performance of small bowel enema.	seventy patients underwent small bowel enema (sbe) to assess the influence of experience of the radiologist on the ease of jejunal intubation and the adequacy of sbe using two types of tubes. comparing intubation time, intubation screening time, total screening time and total room time, we conclude that jejunal intubation is achieved easily, in a reasonable time with both types of tube, by all grades of radiologist, although the experienced operator using the silk tube achieved intubation in a s ...	2009	2713604
predictive value of a short dietary questionnaire for changes in serum lipids in high-risk utah families.	dietary questionnaires and serum cholesterol, triglycerides, and high-density lipoprotein (hdl) cholesterol determinations were completed for 1239 subjects aged greater than or equal to 20 at each of two separate screenings. the mean time between screenings was 2.5 y. after correcting for potential confounding variables, reduction of a measure of dietary cholesterol and saturated fatty acids assessed by two simple questions was a significant independent predictor of reduction in total cholestero ...	2009	2756916
low nanogram detection of nucleotides using fast atom bombardment-mass spectrometry.	the effect of trimethylsilyl (tms) derivatization on detection limits of mononucleotides in fast atom bombardment-mass spectrometry (fab-ms) was examined. fab-ms methods were developed to optimize sensitivity using adenosine 5'-monophosphate as a model compound and then applied to reference standards of two clinically important nucleotides: tricyclic nucleoside-5'-monophosphate (tcnmp) and 5-fluoro-2'-deoxyuridine-5'-monophosphate (fdump). the detection limit for the tms derivative of tcnmp was ...	2009	2729562
[an operative case of multiple endocrine neoplasia type 1 (men type 1) with insulinoma].		2009	2906375
myocardial reperfusion injury: an inflammatory reaction?		2009	2786416
comparison of the high-resolution structures of the alpha-amylase inhibitor tendamistat determined by nuclear magnetic resonance in solution and by x-ray diffraction in single crystals.	the three-dimensional structure of the alpha-amylase inhibitor tendamistat determined by nuclear magnetic resonance in aqueous solution is compared with the tendamistat crystal structure refined at 2.0 a resolution. between the two independently obtained structures the root-mean-square distances are 1.05 a for the backbone atoms n, c alpha and c', 1.25 a for the backbone and the interior side-chains, and 1.84 a for all heavy atoms. these numbers show that the interior of the molecule is nearly i ...	2009	2786963
single-dose intravenous h2 blocker prophylaxis against aspiration pneumonitis: assessment of drug concentration in gastric aspirate.	this placebo-controlled trial compared the effects of preoperative, intravenous cimetidine (300 mg) or ranitidine (50 mg) on gastric ph and gastric volume in 31 adult patients requiring general anesthesia. the elapsed time from drug administration to initial gastric sampling did not differ significantly between ranitidine (45 minutes), cimetidine (48 minutes), or placebo (52 minutes) treated patients. ranitidine, but not cimetidine, significantly (p = 0.02) increased gastric ph when compared wit ...	2009	2773628
hepatic extraction of morphine is impaired in cirrhosis.	using hepatic vein catheterization this study has provided the first direct measurement of morphine hepatic extraction in 8 controls and 8 cirrhotics. the extraction ratio was 0.52 in the control group and was reduced by 25% in the cirrhotics. this reduction is due to impaired enzyme capacity rather than reduced blood flow. the effect of cirrhosis is less than that reported in similar studies of high clearance oxidized drugs and this lends support to the concept that glucuronidation may be relat ...	2009	2753069
wegener's granulomatosis (wg) and insulin dependent diabetes mellitus (iddm).	we report a case of a 14 year-old girl with wegener's granulomatosis (wg) complicated by its direct brain invasion and insulin dependent diabetes mellitus (iddm). this case was diagnosed as wg early in its onset and successfully treated. as for iddm of this case, the presence of hla-dr4 and the islet cell surface antibody (icsa) was demonstrated. to our knowledge, this is the first case report on iddm associated with wg. we consider that wg may precipitate the development of iddm in a geneticall ...	2009	2786968
renal adenocarcinoma presenting with bilateral metastases to bartholin's glands: primary diagnosis by aspiration cytology.	the first recorded case of renal adenocarcinoma presenting with bilateral metastases to the bartholin's glands is presented. primary diagnosis of the metastatic deposits was made by fine-needle aspiration cytology with subsequent localization of the unsuspected renal primary. the value of fine-needle aspiration in the identification of inapparent primary tumors is discussed and cytological findings are described in detail.	2009	3769735
sinusitis and its relationship to asthma.		2009	2687782
sulindac does not spare renal prostaglandins.	it has been suggested that the nonsteroidal anti-inflammatory drug, sulindac, selectively spares renal prostaglandin synthesis. we compared the effect of placebo and sulindac 300 mg daily for one week on furosemide-stimulated renal prostaglandin synthesis in twelve healthy young men. sulindac reduced serum thromboxane b2, a measure of platelet thromboxane a2 production, from 21 +/- 3.9 to 10.9 +/- 2.2 ng/ml (p less than 0.01) but had no effect on body weight, blood pressure or serum creatinine. ...	2009	2650941
adherence assays and slime production of vibrio alginolyticus and vibrio parahaemolyticus.	in this study we investigated the phenotypic slime production of vibrio alginolyticus and vibrio parahaemolyticus strains, food-borne pathogens, using a congo red agar plate assay. furthermore, we studied their ability to adhere to abiotic surfaces and vero cells line. our results showed that only v. alginolyticus atcc 17749 was a slime-producer developing almost black colonies on congo red agar plate. adherence to glace tube showed that all v. alginolyticus strains were more adherent than v. pa ...	2009	24031378
solving problems: down the yellow brick road.		2008	2600651
effect of psoralens and ultraviolet radiation on murine dendritic epidermal cells.	monofunctional psoralens produce less phototoxicity than bifunctional psoralens after ultraviolet a (uva) irradiation. we investigated the effect of repetitive treatments with angelicin (isopsoralen), a monofunctional psoralen, plus uva radiation (ipuva) on the number and morphology of dendritic epidermal cells (dec). this effect was compared with that of 8-methoxypsoralen plus uva radiation (puva), uva alone, and uvb radiation. c3h/hen mice were treated topically with the drugs three times/wk f ...	2008	2565931
ovarian suppression induced with buserelin or danazol in the management of endometriosis: a randomized, comparative study.	the effectiveness of buserelin (hoechst-roussel pharmaceuticals, inc., somerville, nj) (0.2 mg subcutaneously [sc] or 1.2 mg intranasally [in] per day) and danazol (800 mg per day) in inducing ovarian suppression for the management of endometriosis was compared in a prospective randomized study. during 6 months of treatment, peripheral follicle-stimulating hormone (fsh), luteinizing hormone (lh), and estradiol concentrations were suppressed to a similar degree in both groups. symptomatic improve ...	2008	2493400
protocol for rapid chemical rna sequencing.		2008	2443900
impairment of modulating role of testosterone in growth hormone response to clonidine in essential hypertension.	to investigate the effects of endogenous testosterone (t) on the responsiveness of plasma growth hormone (gh) to central alpha 2 adrenergic stimulation, we administered clonidine (0.15 mg, p.o.) to 16 male patients with essential hypertension (eht) and 13 age-matched male normotensive controls (nt). although the basal t level was correlated with the peak gh increment (r = 0.709, p less than 0.01) and with the area under curve of gh (r = 0.714, p less than 0.01) in the nt group, no such correlati ...	2008	2612023
hepatitis b vaccination in ramathibodi health personnel 1986-1987.	hevac-b-pasteur 5 mcg, h-b-vax i 20 mcg, and engerix b 20 mcg, were given to 23, 34, 15 health personnel in ramathibodi hospital. the seroconversion rate for pasteur vaccine was 85 per cent compared to 95 per cent for the other two groups. adverse reactions were few and transient.	2008	2527940
the blood-brain barrier and response of c.n.s. metastases to chemotherapy.	a case demonstrating a differential effect of chemotherapy on a pineal metastasis and parenchymal cerebral metastases is described. at presentation, extensive metastatic small cell carcinoma of the lung was present and ct scanning showed an apparently solitary metastasis in the pineal. the clinical course and serial ct scans showed significant improvement of the pineal tumor and simultaneous development of multiple intra-cerebral metastases. this case confirms that the pineal gland is excluded f ...	2008	2547031
temporal synchronization in the primary auditory response in the pigeon.	spike potentials were recorded from single fibres in the auditory nerve of the pigeon. in responses elicited by tonal stimuli, the timing of each spike relative to stimulus waveform was measured and period histograms were constructed. phase locking of spikes was estimated in terms of a synchronicity index obtained by vector addition within the period histogram. a second measure of synchrony in the spike responses was obtained, that of temporal dispersion. for a population of fibres, vector stren ...	2008	2737971
temporal synchronization in the primary auditory response in the pigeon.	spike potentials were recorded from single fibres in the auditory nerve of the pigeon. in responses elicited by tonal stimuli, the timing of each spike relative to stimulus waveform was measured and period histograms were constructed. phase locking of spikes was estimated in terms of a synchronicity index obtained by vector addition within the period histogram. a second measure of synchrony in the spike responses was obtained, that of temporal dispersion. for a population of fibres, vector stren ...	2008	2737971
evaluating the optometric literature: the educated clinician.	the purpose of this article is to present a framework for reader evaluation of optometric literature. the elements of a research article are outlined. suggestions are presented that clinicians can use to develop competence in evaluating research literature. also presented is an annotated bibliography of research references. better patient care and increased professional growth will result when clinicians evaluate and make use of the research literature.	2008	2703662
evaluating the optometric literature: the educated clinician.	the purpose of this article is to present a framework for reader evaluation of optometric literature. the elements of a research article are outlined. suggestions are presented that clinicians can use to develop competence in evaluating research literature. also presented is an annotated bibliography of research references. better patient care and increased professional growth will result when clinicians evaluate and make use of the research literature.	2008	2703662
on presentation of the friedenwald award of the association for research in vision and ophthalmology to dr. gerald j. chader.		2008	2643586
on presentation of the friedenwald award of the association for research in vision and ophthalmology to dr. gerald j. chader.		2008	2643586
acceptability of day care surgery.	although day case surgery is recommended, its widespread feasibility in an urban environment is unclear. we studied 100 consecutive unselected patients admitted for surgical procedures considered to be suitable for day case surgery. their age, fitness and social details were recorded and they were asked both before surgery and after discharge by a postal questionnaire, whether they would have preferred treatment as an outpatient. there were 47 men and 53 women with a mean age of 42.5 years. nine ...	2008	2614766
fibreoptic laser laparoscopy.	many gynaecologist are now doing more aggressive operative laparoscopic surgery. we feel that procedures which in the past required open laparotomy to be successfully performed, can now be done with fibreoptic laser energy. this chapter reviews our experiences with argon, ktp and nd-yag lasers for advanced laparoscopic surgery. we feel that these fibreoptic lasers allow us to obtain good results with less risk, shortened operating room time and with reduced difficulty during surgery. in this tim ...	2008	2533010
lennox-gastaut syndrome in association with tuberous sclerosis.		2008	2630483
[99mtc-nanocolloid: clinical results of its use as a new inflammation marker].	fifty scintigrams were performed on 45 patients using 99mtc-nanocolloid in order to test its affinity for inflammatory lesions; in these patients there was clinical and/or radiological suspicion of an inflammatory process. there was good correlation between the degree of uptake and the activity of the inflammatory process. specificity is limited because of uptake in certain tumours (eg. sarcomas of the extremities), but difficulties in differential diagnosis are not expected to be serious. judgi ...	2008	2849165
clinical effects of intravenous iloprost in patients with intermittent claudication.	in a randomized patient-blind study iloprost or hydroxy-ethyl starch 200/0.5 were given i.v. 5 h daily for 2 weeks to 24 patients suffering from severe intermittent claudication due to peripheral vascular disease. an increase in pain-free walking distance of more than 50% occurred in 6 of 11 patients after the iloprost infusions and in 7 of 12 patients after hes treatment. no significant effects on haemodynamic or clinical chemistry tests were observed.	2008	2446877
reversal of lymphocyte activation in vivo in the kawasaki syndrome by intravenous gammaglobulin.	the effect of intravenous gammaglobulin (ivgg) on the immunoregulatory abnormalities found during acute kawasaki syndrome (ks) was studied in a randomized trial of ivgg plus aspirin (asa) versus asa alone. before therapy, patients in each treatment group had increased numbers of circulating hla-dr-bearing leu 3+ helper t cells, a deficiency of leu 2+ suppressor/cytotoxic t cells, and increased levels of spontaneous igg and igm synthesis by peripheral blood mononuclear cells. there were no signif ...	2008	2433307
a reticuloendothelial system-activating arabinoxylan from the bark of cinnamomum cassia.	a neutral polysaccharide, named cinnaman ax, was isolated from the dried bark of cinnamomum cassia blume. it was homogeneous on electrophoresis and gel chromatography. it is composed of l-arabinose: d-xylose in the molar ratio of 4:3, and its molecular weight was estimated to be about 1.0 x 10(6). methylation analysis, carbon-13 nuclear magnetic resonance and controlled smith degradation studies enabled elucidation of its structural features. it showed remarkable reticuloendothelial system-poten ...	2008	2632069
a reticuloendothelial system-activating arabinoxylan from the bark of cinnamomum cassia.	a neutral polysaccharide, named cinnaman ax, was isolated from the dried bark of cinnamomum cassia blume. it was homogeneous on electrophoresis and gel chromatography. it is composed of l-arabinose: d-xylose in the molar ratio of 4:3, and its molecular weight was estimated to be about 1.0 x 10(6). methylation analysis, carbon-13 nuclear magnetic resonance and controlled smith degradation studies enabled elucidation of its structural features. it showed remarkable reticuloendothelial system-poten ...	2008	2632069
[nucleotide sequence of the b1-hordein gene of barley hordeum vulgare l].	the gene encoding b1 hordein of hordeum vulgare (cv. donetsky 4) was cloned and entirely sequenced. it contains no introns and codes for of 293 amino acids long polypeptide with molecular weight 33418. our clone differs from the previously sequenced b1 hordein genes in some positions within the coding region (there are 4 nucleotide changes and a 12 bp deletion, as compared with the pb11 cdna clone, and 5 nucleotide changes, as compared with the pbhp184 genomic clone). these changes result in pol ...	2008	2583483
[nephrotic syndrome].		2008	2293261
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
colony-stimulating factor and drug-induced agranulocytosis.		2008	2655524
panic attacks, buspirone, and serotonin function.		2008	2570299
the difference between duchenne and becker dystrophies.		2008	2648189
the difference between duchenne and becker dystrophies.		2008	2648189
[therapy monitoring of regional chemotherapy by magnetic resonance spectroscopy].		2008	2474953
binding modes of mammalian hepatic gal/galnac receptors.	mammalian gal/galnac receptors show dramatic preference for three-branched oligosaccharide structures over two- or one-branched counterparts. the spatial arrangement of the gal residues is extremely important for optimal binding. the three terminal gal residues in the best triantennary ligand are about 15-30 a apart, and therefore the sugar-combining sites on the receptor may also have the same geometry. the results obtained with synthetic ligands containing gal or galnac are in agreement with t ...	2008	2551610
[a case of an s-shaped kidney complicated by calculosis and hydronephrosis].		2008	2585989
[regional blood lactate level in arterial occlusive diseases].	fifty-seven patients with obliterating diseases of the lower limb arteries were examined. the concentration of lactate in the venous blood and the venous-arterial difference in the blood lactate level in the affected limb were found to be increased. a relationship between the marked character of these shifts and the severity of the ischemic syndrome was noted. the authors discuss the possibility of using the values of the lactate content in the regional blood as criteria for evaluating the effic ...	2008	2292851
effects of sodium depletion on the caffeine-induced contraction of frog's skeletal muscle.	effects of depletion of na ions from the environmental medium on the caffeine-induced contraction were investigated in both intact and skinned fibers prepared from the frog's fast twitch muscle. in intact muscle fibers, both the twitch and the contracture induced by 5 mm caffeine were enhanced by depleting the external na at 9-10 degrees c. in contrast, in the mechanically skinned muscle fiber, which was used to examine the capability of the sarcoplasmic reticulum to take up ca ions from the sar ...	2008	2395238
preventing nervous system sports injuries.	physical fitness and sports remain integral components of overall good health and a cornerstone of preventive medicine. when performed safely, under adequate supervision, and with appropriate protective gear, most of these activities are enjoyable, healthful and psychologically gratifying. when not performed safely by trained athletes, these same activities can be treacherous, injurious and permanently disabling. the goals of this article are to review and describe low-risk and high-risk sports ...	2008	2648209
preventing nervous system sports injuries.	physical fitness and sports remain integral components of overall good health and a cornerstone of preventive medicine. when performed safely, under adequate supervision, and with appropriate protective gear, most of these activities are enjoyable, healthful and psychologically gratifying. when not performed safely by trained athletes, these same activities can be treacherous, injurious and permanently disabling. the goals of this article are to review and describe low-risk and high-risk sports ...	2008	2648209
[humeroscapular periarthritis].		2008	2620726
[humeroscapular periarthritis].		2008	2620726
[monoclonal antibodies to individual antigens of the nervous system of the snail, helix pomatia].	seven positive hybridoma clones were chosen by immunoenzyme analysis amons 103 clones obtained by hybridization of nso plasmocytoma cells and splenocytes from balb/c mice, immunized with snail's nervous system antigens. specific binding of mabs with neuron cytoplasmic antigens was indicated on cryostat sections of visceral, pedal and cerebral ganglia. the mabs obtained could be used for the study of physiological role of antigens identified.	2008	2268718