Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| synthesis, spectral and biological evaluation of some new thiazolidinones and thiazoles based on t-3-alkyl-r-2,c-6-diarylpiperidin-4-ones. | a stereospecific synthesis of some thiazolidinones and thiazoles was achieved conveniently through certain alpha-halo keto agents and reactivity of chloroacetyl chloride was successfully enhanced by csf-celite+ch(3)coona. nmr studies revealed that the configuration of n-n bond is found to be anti with respect to c-3 alkyl group while c=n bond in thiazolidinone is trans with respect to n-n bond. antimycobacterial activity tested against mycobacterium tuberculosis indicated that compounds 19, 20, ... | 2009 | 19535178 |
| macrophage elastase kills bacteria within murine macrophages. | macrophages are aptly positioned to function as the primary line of defence against invading pathogens in many organs, including the lung and peritoneum. their ability to phagocytose and clear microorganisms has been well documented. macrophages possess several substances with which they can kill bacteria, including reactive oxygen species, nitric oxide, and antimicrobial proteins. we proposed that macrophage-derived proteinases may contribute to the antimicrobial properties of macrophages. macr ... | 2009 | 19536155 |
| structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. | the ability to respond to light is crucial for most organisms. bluf is a recently identified photoreceptor protein domain that senses blue light using a fad chromophore. bluf domains are present in various proteins from the bacteria, euglenozoa and fungi. although structures of single-domain bluf proteins have been determined, none are available for a bluf protein containing a functional output domain; the mechanism of light activation in this new class of photoreceptors has thus remained poorly ... | 2009 | 19536266 |
| dissemination of escherichia coli with ctx-m type esbl between humans and yellow-legged gulls in the south of france. | extended spectrum beta-lactamase (esbl) producing enterobacteriaceae started to appear in the 1980s, and have since emerged as some of the most significant hospital-acquired infections with escherichia coli and klebsiella being main players. more than 100 different esbl types have been described, the most widespread being the ctx-m beta-lactamase enzymes (bla(ctx-m) genes). this study focuses on the zoonotic dissemination of esbl bacteria, mainly ctx-m type, in the southern coastal region of fra ... | 2009 | 19536298 |
| [microbial spectrum in surgical infections based on a microbiological routine monitoring over the 10-year period from 1995 to 2004]. | infections belong to the most frequent and dangerous complications in surgery. in addition to the medical aspects, these infections may have a significant impact on the costs and the overall economic efficacy of medical treatment under the present circumstances of drg. | 2009 | 19536716 |
| impact of infection on the secretory capacity of the male accessory glands. | studies that compare the impact of different infectious entities of the male reproductive tract (mrt) on the male accessory gland function are controversial. | 2009 | 19538765 |
| [pneumoperitoneum secondary to spontaneous gaseous gangrene of the pancreas due to klebsiella sp]. | 2009 | 19539404 | |
| synthesis and evaluation of in vitro anti-microbial and anti-tubercular activity of 2-styryl benzimidazoles. | a new series of novel 5-(nitro/bromo)-styryl-2-benzimidazoles (1-12) has been synthesized by simple, mild and efficient synthetic protocol by attempted condensation of 5-(nitro/bromo)-o-phenylenediamine with trans-cinnamic acids in ethylene glycol. screening for in vitro anti-tubercular activity against mycobacterium tuberculosis h(37) rv, anti-bacterial activity against staphylococcus aureus, escherichia coli, enterococcus faecalis, klebsiella pneumoniae bacterial strains and anti-fungal activi ... | 2009 | 19540630 |
| high prevalence of bla(ctx-m-1)-group extended-spectrum beta-lactamase genes in enterobacteriaceae isolates from emilia-romagna, italy. | 2009 | 19541784 | |
| infections in patients with aplastic anemia. | infection is a major cause of death in patients with aplastic anemia (aa). there are differences between the immunocompromised state of a patient with aa and the patient who is neutropenic due to chemotherapy and this leads to a difference in the infections that they incur. prolonged neutropenia is one of the largest risk factors for the development of infections with the invasive mycoses and bacteria. recovery from neutropenia is directly related to survival, and supportive care plays a large r ... | 2009 | 19549579 |
| evaluation of antibacterial activity, phenol and flavonoid contents of thespesia populnea flower extracts. | flavonoids which were reported as having many pharmacological activities, antimicrobial, antioxidant, cytotoxic, chemoprevention activities and they possess strong antiproliferative effects related to inhibition of cell cycle progression and apoptosis induction. on the basis of this thespesia populnea (l.) sol. ex correa (family-malvaceae) was selected and it is having the major composition of flavonoids and the antibacterial activity of methanolic extract of thespesia populnea flowers was inves ... | 2009 | 19553175 |
| nationwide surveillance of bacterial respiratory pathogens conducted by the japanese society of chemotherapy in 2007: general view of the pathogens' antibacterial susceptibility. | for the purpose of a nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens in patients in japan, the japanese society of chemotherapy conducted their second year survey, during the period from january to august, 2007. a total of 1178 strains were collected from clinical specimens obtained from adult patients with well-diagnosed respiratory tract infections. susceptibility testing was evaluable for 1108 strains (226 staphylococcus aureus, 257 streptococcus ... | 2009 | 19554400 |
| [multicenter study of in vitro activity of tigecycline in clinical isolates from 30 centers in spain]. | in the last years, the increase of antibiotic resistances of gram-positive and gram-negative bacteria is an important therapeutic problem. the antimicrobial activity of tigecycline, a novel glycylcycline, was evaluated against 750 bacterial isolates from 30 centers in spain. | 2009 | 19554486 |
| saturation-mutagenesis in two positions distant from active site of a klebsiella pneumoniae glycerol dehydratase identifies some highly active mutants. | synthesis of 1,3-propanediol (1,3-pd) from glycerol through the biotransformation process requires two steps, catalyzed by glycerol dehydratase (gdht) and 1,3-pd oxidoreductase. gdht is the rate-limiting enzyme in this process. all recombinant microorganisms for production of 1,3-pd so far utilized the natural genes that may not have been optimized. two positions, which are 19.3a and 29.6a away from the active site in gdht from klebsiella pneumoniae, were subjected to saturation-mutagenesis and ... | 2009 | 19555728 |
| contribution of ompk36 to carbapenem susceptibility in kpc-producing klebsiella pneumoniae. | isolates of klebsiella pneumoniae harbouring the carbapenemase kpc may have carbapenem mics that remain in the susceptible range, and may therefore go unrecognized. to understand the mechanisms contributing to the variability in carbapenem mics, 20 clinical isolates, all belonging to either of two clonal groups of kpc-possessing k. pneumoniae endemic to new york city, were examined. expression of genes encoding kpc, the porins ompk35 and ompk36, and the efflux pump acrab was examined by real-tim ... | 2009 | 19556371 |
| crystalline bacterial biofilm formation on urinary catheters by urease-producing urinary tract pathogens: a simple method of control. | the problem of catheter encrustation stems from infection by urease-producing bacteria. these organisms generate ammonia from urea, elevate the ph of urine and cause crystals of calcium and magnesium phosphates to form in the urine and the biofilm that develops on the catheter. in this study, a laboratory model was used to compare the ability of 12 urease-positive species of urinary tract pathogens to encrust and block catheters. proteus mirabilis, proteus vulgaris and providencia rettgeri were ... | 2009 | 19556373 |
| oral care interventions and oropharyngeal colonization in children receiving mechanical ventilation. | recent progress in identification of oral microorganisms has shown that the oropharynx can be a site of origin for dissemination of pathogenic organisms to distant body sites, such as the lungs. | 2009 | 19556410 |
| prevalence of qnr determinants among extended-spectrum beta-lactamase-positive enterobacteriaceae clinical isolates in southern stockholm, sweden. | three hundred and nineteen extended-spectrum beta-lactamase-positive enterobacteriaceae clinical isolates were screened for qnr genes. twelve isolates were positive for qnr, including one qnra1, two qnrb1, three qnrb2, one qnrb4, one qnrb6 and four qnrs1. no qnr-positive strains were identified among the isolates recovered before 2006. the first qnr-positive escherichia coli was detected from a patient in 2006. qnr genes remained rare in e. coli (6/288; 2.1%), but appeared to be more prevalent i ... | 2009 | 19409763 |
| composition and antimicrobial activity of marrubium incanum desr. (lamiaceae) essential oil. | the essential oil from the aerial parts of marrubium incanum desr. (lamiaceae), obtained by hydrodistillation, was analyzed by gc and gc-ms. forty-six compounds were identified, representing 96.3% of the total oil. the main components of the oil were (e)-caryophyllene (27.0%), germacrene d (26.2%) and bicyclogermacrene (11.5%). the microbial growth inhibitory properties of the isolated essential oil were determined using the agar diffusion and broth microdilution method against seven bacterial s ... | 2009 | 19413128 |
| increase in detectable opportunistic bacteria in the oral cavity of orthodontic patients. | this study was performed to detect the opportunistic bacteria and fungi from the oral cavities of orthodontic patients and examine the ability of the organisms to adhere to saliva-coated metallic brackets. | 2009 | 19416094 |
| resistance patterns of bacterial isolates to antimicrobials from 3 hospitals in the united arab emirates. | to compare the resistance pattern of common bacterial pathogens to commonly used drugs. | 2009 | 19417958 |
| risk factors, clinical manifestation and bacteriological profile of neonatal sepsis in a tertiary level pediatric hospital. | this prospective study was undertaken in dhaka shishu hospital, bangladesh from 15th oct. 2005 to 15th october 2006 to determine the risk factors, clinical manifestation and bacteriological profile of neonatal sepsis. eighty suspected cases of septicaemia admitted in neonatal ward of dhaka shishu hospital were included in this study. patients, who had history of perinatal asphyxia, congenital cyanotic heart disease etc. were excluded from the study. thirty neonates without signs & symptoms of se ... | 2009 | 19377435 |
| organisms associated with ventilator associated pneumonia in intensive care unit. | it is a cross sectional observational study. place of study was the icu of square hospitals ltd. and icu of bangabandhu sheikh mujib medical university (bsmmu). all patients who were diagnosed as a case of ventilator associated pneumonia (vap) in icu during the one year study period (01.01.2006 to 31.12.2006) were included in this study. data was collected by patient's clinical register, checklist. total number of patients was 43. main objective of our study was to identify the organisms associa ... | 2009 | 19377438 |
| first detection of plasmid-encoded blaoxy beta-lactamase. | three klebsiella oxytoca isolates and one klebsiella pneumoniae isolate from three children admitted to the hematology unit of hospital vall d'hebron (barcelona, spain) exhibited a susceptibility pattern suggesting oxy beta-lactamase hyperproduction. all the isolates contained a 95-kb plasmid that harbored bla(oxy-1), which was transferred by electrotransformation but could not be self-transferred by conjugation. a qnrs1 gene was also harbored in the bla(oxy-1)-carrying plasmid. this is the firs ... | 2009 | 19380592 |
| the oligomeric assembly of the novel haem-degrading protein hbps is essential for interaction with its cognate two-component sensor kinase. | hbps, a novel protein of previously unknown function from streptomyces reticuli, is up-regulated in response to haemin- and peroxide-based oxidative stress and interacts with the sens/senr two-component signal transduction system. in this study, we report the high-resolution crystal structures (2.2 and 1.6 a) of octomeric hbps crystallized in the presence and in the absence of haem and demonstrate that iron binds to surface-exposed lysine residues of an octomeric assembly. based on an analysis o ... | 2009 | 19244623 |
| outbreak of infections due to kpc-2-producing klebsiella pneumoniae in a hospital in crete (greece). | starting in may 2007, an ongoing outbreak of infections due to carbapenem resistant kpc-2-producing klebsiella pneumoniae occurred in a tertiary care hospital in crete (greece). the outbreak involved 22 patients, none of whom had travelled in a country with known high prevalence of such isolates. kpc-producing k. pneumoniae strains were mainly isolated from patients admitted in the intensive care unit, on mechanical ventilation, with prolonged hospitalization, prolonged administration of antibio ... | 2009 | 19246099 |
| factors associated with bacteremia due to multidrug-resistant gram-negative bacilli in hematopoietic stem cell transplant recipients. | the epidemiology of bacteremia developing during neutropenia has changed in the past decade, with the re-emergence of gram-negative (gn) bacteria and the development of multidrug resistance (mdr) among gn bacteria. we conducted a case-control study in order to identify factors associated with bacteremia due to multidrug-resistant gram-negative (mdrgn) isolates in hematopoietic stem cell transplant recipients. ten patients with mdrgn bacteremia were compared with 44 patients with gn bacteremia wi ... | 2009 | 19287908 |
| prevalence of aac(6')-ib-cr encoding a ciprofloxacin-modifying enzyme among enterobacteriaceae blood isolates in korea. | the aac(6')-ib gene was detected in 86 of 555 (15.5%) enterobacteriaceae isolates. among these 86 aac(6')-ib-positive isolates, 19 (22.0%) were positive for aac(6')-ib-cr: 4 of 31 (12.9%) enterobacter spp., 7 of 13 (53.8%) escherichia coli isolates, and 8 of 42 (19.0%) klebsiella pneumoniae isolates. there was a strong association between aac(6')-ib-cr and oxa-1 and ctx-m-1 group beta-lactamase genes. one aac(6')-ib-positive k. pneumoniae isolate carried both aac(6')-ib-cr and qnrs. | 2009 | 19289526 |
| in vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. | we investigated in vitro activities of piperacillin or cefoperazone alone and in combination with beta-lactamase inhibitors against gram-negative bacilli. piperacillin/tazobactam 8:1 lowered resistance for escherichia coli, serratia marcescens, enterobactaer cloacae, klebsiella pneumoniae and imipenem-susceptible acinetobacter baumannii. when piperacillin was combined with sulbactam 2:1 or 4:1, resistance against e. coli, s. marcescens, e. cloacae, extended spectrum beta-lactamase (esbl)-k. pneu ... | 2009 | 19382669 |
| prevalence and spread of pseudomonas aeruginosa and klebsiella pneumoniae strains in patients with hematological malignancies. | the aim of the study was to determine the prevalence of pseudomonas aeruginosa and klebsiella pneumoniae strains in patients with acute leukemias, to assess their clinical significance, and to define the sources and ways of their spread using genetic analysis. thirty-four patients were investigated during the observed period. twenty-one strains of pseudomonas aeruginosa and 35 strains of klebsiella pneumoniae were isolated from patient samples. in the case of pseudomonas aeruginosa, 47.6% of str ... | 2009 | 19382671 |
| eradication of microorganisms embedded in biofilm by an ethanol-based catheter lock solution. | interdialytic locking of catheters with antimicrobial agents is frequently used for preventing catheter-related infections, often associated with biofilm formation. we determined the bactericidal effect of 60% ethanol (etoh) versus a 46.7% trisodium citrate (tsc) solution on biofilm embedded in silicone catheters. | 2009 | 19383833 |
| role of azithromycin against clinical isolates of family enterobacteriaceae: a comparison of its minimum inhibitory concentration by three different methods. | to determine the effect of azithromycin, a new azalide antibiotic, on clinical isolates of the family enterobacteriaceae and to determine and compare its minimum inhibitory concentration (mic) by disk diffusion, agar dilution and e-test methods. | 2009 | 19384031 |
| diagnosis of spontaneous bacterial peritonitis: role of tween 80 and triton x in ascitic fluid cultures. | a patient with alcoholic cirrhosis of the liver, portal hypertension with hepatic encephalopathy and spontaneous bacterial peritonitis (sbp) was admitted in an obtunded condition. attempts at delineating the aetiology of the sbp using conventional cultures as well as automated systems were not successful. the use of non-anionic surfactant agents such as tween 80-incorporated blood agar and triton x treatment of the specimens facilitated the growth of klebsiella pneumoniae from the ascitic fluid, ... | 2009 | 19384043 |
| in vitro biological activity screening of lycopodium complanatum l. ssp. chamaecyparissus (a. br.) doll. | this article reports the results of selected biological activities, including anticholinesterase, antioxidant, antibacterial, antifungal and antiviral properties, of the petroleum ether, chloroform and methanol extracts as well as the alkaloid fraction of lycopodium complanatum l. ssp. chamaecyparissus (a. br.) doll (lcc, lycopodiaceae) growing in turkey. anticholinesterase effect of the extracts was tested against both acetylcholinesterase (ache) and butyrylcholinesterase (bche) at concentratio ... | 2009 | 19384728 |
| a pain in the neck -- an unexpected complication of transrectal ultrasound and biopsy. | in the uk, over 26 000 cases of prostate cancer are diagnosed annually, with many more patients undergoing investigation. prostate-specific antigen (psa) testing and its interpretation has always been controversial. many patients undergo psa-driven biopsies, which can cause significant morbidity. we report an unusual but severe complication following transrectal ultrasound and biopsy. | 2009 | 19386955 |
| field applications of a bio-trickling filter for the removal of nitrogen oxides from flue gas. | a bio-trickling filter (btf) packed with polyhedral spheres was used to remove nitrogen oxides (nox) from the flue gas of a coal-fired power plant. the btf system consistently removed 64-95% of the nox after start-up and acclimation under dynamic conditions (e.g., 120-240 m(3)/h flue gas flow rate and inlet 300-900 mg nox/m(3)). scanning electron microscopy of the biofilms that were formed showed a shift in the predominating bacteria. analyses by pcr-denaturing gradient gel electrophoresis showe ... | 2009 | 19387558 |
| the prevalence of extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae among clinical isolates from a general hospital in iran. | this study was conducted at a 900+ bed general teaching hospital, from may to september 2007, in iran. the aim of this study was to determine the prevalence of extended-spectrum beta-lactamase (esbl) producing escherichia coli and klebsiella pneumoniae and their antimicrobial pattern. the kirby-bauer disk diffusion method and the phenotypic disk confirmatory test were performed for each isolate. the total of 206 isolates including 106 e. coli and 100 k. pneumoniae were collected of which 122 iso ... | 2009 | 19388560 |
| prevalence and antimicrobial susceptibility of gram-negative bacteria isolated from bovine mastitis between 2003 and 2008 in korea. | the objective of this study was to assess trends in the prevalence and distribution of gram-negative bacteria isolated from bovine mastitis and their antimicrobial susceptibilities during a 6-yr period between 2003 and 2008 in korea. escherichia coli, pseudomonas fluorescens, klebsiella pneumoniae, enterobacter cloacae, acinetobacter lwoffi/junii, pseudomonas aeruginosa, and serratia marcescens were the most commonly observed pathogens during this period. generally, gram-negative bacteria showed ... | 2009 | 19389959 |
| endoscopic ultrasound-guided aspiration and oral antibiotic therapy as definitive treatment of an asymptomatic pancreatic abscess. | 2009 | 19390411 | |
| treatment of strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient. | we report a case of strongyloides stercoralis hyperinfection syndrome in a renal transplant recipient complicated by septic shock, acute respiratory distress syndrome, and klebsiella pneumoniae superinfection. the patient was treated successfully with drotrecogin alfa (activated), parenteral ivermectin, albendazole, and piperacillin/tazobactam. this outcome suggests that drotrecogin alfa (activated) may be useful therapy for transplant recipients who develop severe sepsis or septic shock seconda ... | 2009 | 19392733 |
| correlation between time to positivity of blood cultures with clinical presentation and outcomes in patients with klebsiella pneumoniae bacteraemia: prospective cohort study. | time to positivity (ttp) of blood cultures in patients with bacteraemia is considered to be a predictor of outcome for some bacterial species. two hundred and thirty-one patients with klebsiella pneumoniae monomicrobial bacteraemia at a hospital from 1 january to 31 december 2007 were prospectively enrolled. ttp <7 h (46 patients, 19.9%) was associated with a higher pittsburg bacteraemia score (6.2 +/- 5.5 vs. 3.7 +/- 4.3, p 0.002), fewer non-fatal diseases by the mccabe classification (39.1% vs ... | 2009 | 19392886 |
| two chromosomally located qnrb variants, qnrb6 and the new qnrb16, in citrobacter spp. isolates causing bacteraemia. | the objective of this study was to determine the prevalence of the plasmid-borne quinolone resistance genes qnra, qnrb and qnrs in a collection of enterobacteriaceae causing bacteraemia. the presence of the three genes was tested for using multiplex pcr in 306 clinical isolates. plasmid analysis was performed using i-ceui and s1 nuclease digestion and hybridization with specific probes for the qnr and 23s rrna genes. five strains were found to carry a qnr gene, one of which, qnrb16, a new varian ... | 2009 | 19392890 |
| microbial tolerance in secondary peritonitis is dose dependent. | local microbial tolerance was investigated in a murine model of peritonitis. peritoneal bacterial burden and inflammatory cytokine concentrations were determined at different times, within 48h after infection. peritoneal macrophages were harvested from naïve mice or from mice 48h after infection and underwent ex vivo stimulation with different concentrations of klebsiella. cytokine secretion was determined in the supernatants. peritoneal bacteria concentrations, remained relatively steady betwee ... | 2009 | 19393606 |
| [candida-induced recurrent peritonitis after peritoneal catheter reinsertion]. | 2009 | 19396335 | |
| high production of 2,3-butanediol from glycerol by klebsiella pneumoniae g31. | the microbial production of high amounts of 2,3-butanediol (2,3-bd) from glycerol as a sole carbon source by the bulgarian isolate klebsiella pneumoniae g31 was studied in a series of fed-batch processes. the following conditions were evaluated as optimal: micro-aerobic cultivation in modified media, without ph control. beginning at ph 8, 49.2 g/l of 2,3-bd was produced as negligible concentrations of by-products were received. the ph is the most important factor ruling the 2,3-bd production. sp ... | 2009 | 19396438 |
| acute pyelonephritis: clinical characteristics and the role of the surgical treatment. | the epidemiology of acute pyelonephritis (apn) has changed with time. therefore we investigated the current clinical characteristics of apn and the significance of proper surgical management for treatment of 1,026 apn patients in south korea for the past 5 yr. the male-to-female ratio was about 1:8. the peak ages of female patients were 20s (21.3%) and over 60s (23.7%), while that of male was over 60s (38.1%). the occurrence of sepsis was 10.1%. complicated apn patients were 35.4%. ninety-four p ... | 2009 | 19399273 |
| clinical features of neonatal sepsis caused by resistant gram-negative bacteria. | clinical features and outcomes of neonatal sepsis caused by resistant gram-negative bacteria are not well described in jordan. the aim of the present study was therefore to describe microbiology and clinical features, laboratory findings and outcomes of early- and late-onset gram-negative neonatal sepsis. | 2009 | 19400829 |
| klebsiella pneumoniae carbapenemase, canada. | 2009 | 19402984 | |
| pharmacokinetic considerations regarding tigecycline for multidrug-resistant (mdr) klebsiella pneumoniae or mdr acinetobacter baumannii urosepsis. | 2009 | 19403778 | |
| retrospective analysis of clinical profile prognostic factors and outcomes of 19 patients of emphysematous pyelonephritis. | we aimed to study the clinical profile, prognostic factors, and the 6-month outcome of patients with emphysematous pyelonephritis (epn) methods: all patients admitted with a diagnosis of emphysematous pyelonephritis between january 2001 and july 2007 were included. | 2009 | 19404766 |
| paradoxical effect of klebsiella pneumoniae ompk36 porin deficiency. | to evaluate the effect of defined mutations in the major ompk35 and ompk36 porins in klebsiella pneumoniae on the activity of two common plasmid-mediated ampc enzymes. | 2009 | 19404854 |
| can we rely on one laboratory test in detection of extended-spectrum beta-lactamases among enterobacteriaceae? an evaluation of the vitek 2 system and comparison with four other detection methods in kuwait. | background and | 2009 | 19406738 |
| new "on-off"-type nanobiodetector. | a new type of nanobiodetector based on a limited number of polyaniline nanofibrils has been designed and tested against bacteria klebsiella pneumoniae, pseudomonas aeruginosa, escherichia coli and enterococcus faecalis. the cells attaching conducting nanofibrils modify locally the electrical conductivity making the polymer nanowires electrically inhomogeneous. the "defects" accumulate in nanofibrils changing suddenly their electrical conductivity above a threshold density (the percolation limit) ... | 2009 | 19327977 |
| [extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae in spanish hospitals: 2nd multicenter study (geih-blee project, 2006)]. | during the year 2000, the 1st nationwide project (geih-blee project 2000) on escherichia coli and klebsiella pneumoniae producing extended-spectrum ss-lactamases (esbl) was carried out in spain. the 2nd nationwide study was developed in 2006 to investigate the evolution of this problem. | 2009 | 19329230 |
| carbapenem-resistant klebsiella pneumoniae endocarditis in a young adult. successful treatment with gentamicin and colistin. | enterobacteriaceae are rarely the etiologic agents of endocarditis, with klebsiella species being especially rare. from the end of 2005, isolates of carbapenem-resistant klebsiella pneumoniae began to appear in various hospitals across israel, sensitive only to colistin and gentamicin. we present a case of hospital-acquired endocarditis caused by carbapenem-resistant k. pneumoniae in a young adult. | 2009 | 19329345 |
| activity of temocillin against kpc-producing klebsiella pneumoniae and escherichia coli. | 2009 | 19332667 | |
| early dissemination of kpc-2-producing klebsiella pneumoniae strains in brazil. | 2009 | 19332672 | |
| molecular cloning and characterization of taiwan macaque lactoferrin. | lactoferrin (lf) is an iron-binding glycoprotein that plays an important role in combating a wide range of pathogens and contributes innate protective defenses of mammals. | 2009 | 19335476 |
| inorganic antimicrobial coating for titanium alloy and its effect on bacteria. | for orthopedic implants, infection is a serious problem. therefore, we considered an implant with antimicrobial ability can prevent infection. we tried to coat a titanium alloy surface with novaron, a commercially available inorganic antimicrobial. the purpose of this study was to analyze the differences among the surfaces of materials coated using different processing pressures of the working gas and analysis of the antimicrobial activity. | 2009 | 19337813 |
| a new central venous catheter cap: decreased microbial growth and risk for catheter-related bloodstream infection. | catheter-related blood stream infection (crbi) is a major cause of morbidity and mortality, and is a source of significant healthcare expenditures in patients that require central venous catheters for intravenous nutrition, chemotherapy, and other products. the source of many catheter-related infections is contamination of the catheter hub. herein an antimicrobial catheter cap, the ab cap is described. | 2009 | 19340794 |
| first identification of class a carbapenemase-producing klebsiella pneumoniae in the republic of ireland. | the klebsiella pneumoniae carbapenemase (kpc) was detected in a carbapenem-resistant respiratory isolate of klebsiella pneumoniae in an irish hospital. this is the first report of a kpc-producing isolate in the republic of ireland. the isolate was resistant to all beta-lactams. furthermore, it had reduced susceptibility to three other classes of non-beta-lactam antibiotics. the isolate was not associated with travel abroad. detection of kpc-producing bacteria has important infection control and ... | 2009 | 19341609 |
| antimicrobial susceptibility of tigecycline and comparators against bacterial isolates collected as part of the test study in europe (2004-2007). | tigecycline is a broad-spectrum antimicrobial agent that has been approved for the treatment of skin and soft-tissue infections as well as intra-abdominal infections. the tigecycline evaluation and surveillance trial (test) is a global, longitudinal surveillance study established in 2004 to monitor the in vitro activity of tigecycline and comparator agents against key gram-negative and gram-positive pathogens. this report examines data obtained for 24748 isolates collected across 24 european cou ... | 2009 | 19342205 |
| lipocalin 2 is required for pulmonary host defense against klebsiella infection. | antimicrobial proteins comprise a significant component of the acute innate immune response to infection. they are induced by pattern recognition receptors as well as by cytokines of the innate and adaptive immune pathways and play important roles in infection control and immunomodulatory homeostasis. lipocalin 2 (siderocalin, ngal, 24p3), a siderophore-binding antimicrobial protein, is critical for control of systemic infection with escherichia coli; however, its role in mucosal immunity in the ... | 2009 | 19342674 |
| oscar the cat, carbapenem-resistant klebsiella pneumoniae, and attributable mortality. | 2009 | 19344272 | |
| tigecycline in the treatment of infections from multi-drug resistant gram-negative pathogens. | this observational retrospective study aims to present early experience with tigecycline (tig) in the treatment of infections due to multi-drug resistant (mdr) microorganisms. | 2009 | 19344841 |
| clinical outcomes of patients with klebsiella pneumoniae carbapenemase-producing k. pneumoniae after treatment with imipenem or meropenem. | klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae may appear susceptible to imipenem or meropenem by routine susceptibility testing. we report a series of patients with infections caused by k. pneumoniae isolates, which yielded imipenem-susceptible results but were subsequently kpc-positive by polymerase chain reaction. when these infections were treated with imipenem or meropenem, frequent clinical and microbiologic failures were observed. | 2009 | 19345034 |
| additive antimicrobial [corrected] effects of the active components of the essential oil of thymus vulgaris--chemotype carvacrol. | herbal remedies are multicomponent mixtures by their nature as well as by pharmaceutical definition. being a multicomponent mixture is not only a crucial property of herbal remedies, it also represents a precondition for interactions such as synergism or antagonism. until now, only a few phytomedicines are accurately described concerning the interactions of their active components. the aim of this study was to search for interactions within such a naturally given multi-component mixture and to d ... | 2009 | 19347798 |
| [antibiotic-resistant infectious thoracoabdominal aortic aneurysm; report of a case]. | a 76-year-old female presented with constipation and anorexia computed tomography (ct) revealed a saccular aneurysm (35 mm in diameter) directly over the root of the celiac artery, and she was referred to our department and was admitted. klebsiella pneumoniae was detected in blood culture. although antibiotics were administered, the inflammatory response was not improved. on day 8 after hospitalization, ct revealed the aneurysm increased. therefore, surgery was performed. aneurysm was observed a ... | 2009 | 19348220 |
| in vitro activity of ceftaroline alone and in combination against clinical isolates of resistant gram-negative pathogens, including beta-lactamase-producing enterobacteriaceae and pseudomonas aeruginosa. | ceftaroline is a novel broad-spectrum cephalosporin that exhibits bactericidal activity against many gram-positive and -negative pathogens. however, the activity of ceftaroline cannot be solely relied upon for eradication of multidrug-resistant gram-negative isolates, such as pseudomonas aeruginosa and extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae, which represent a current clinical concern. as drug combinations might be beneficial by potential synergy, we evaluated the in ... | 2009 | 19349512 |
| analysis of bla(shv) codon 238 and 240 allele mixtures using sybr green high-resolution melting analysis. | klebsiella pneumoniae isolates frequently contain complex mixtures of bla(shv) alleles. a high-resolution melting-based method for interrogating the extended-spectrum activity conferring codon 238 and 240 polymorphisms was developed. this detects minority extended-spectrum beta-lactamase-encoding alleles, allows estimation of allele ratios, and discriminates between single and double mutants. | 2009 | 19349515 |
| role of klebsiella and collagens in crohn's disease: a new prospect in the use of low-starch diet. | crohn's disease is suggested to result from a microbially triggered immune-mediated autoimmune process, involving mainly the terminal ileum and ileo-caecal junction. klebsiella pneumoniae shares certain molecular structures present in pullulanase pula and puld secretion enzymes with various self-antigens present in collagens and hla-b27 molecules, respectively. a link exists between high dietary starch intake and the growth of intestinal microflora, involving especially klebsiella microbes. incr ... | 2009 | 19352192 |
| elimination of by-product formation during production of 1,3-propanediol in klebsiella pneumoniae by inactivation of glycerol oxidative pathway. | the microbial production of 1,3-propanediol (1,3-pd) by klebsiella pneumoniae involves the formation of various by-products, which are synthesized through the oxidative pathway. to eliminate the by-products synthesis, the oxidative branch of glycerol metabolism was inactivated by constructing two mutant strains. in one of the mutant strains, the structural genes encoding glycerol dehydrogenase and dihydroxyacetone kinase were deleted from the chromosomal dna, whereas in the second mutant strain ... | 2009 | 19352645 |
| prevalence, antibiotic susceptibility pattern and production of extended-spectrum beta-lactamases amongst clinical isolates of klebsiella pneumoniae at armed forces hospital in saudi arabia. | the aim of this descriptive study was to determine the prevalence of klebsiella pneumoniae from different clinical specimens, their antibiotic susceptibility pattern and the extended-spectrum beta-lactamase (esbl) production among such isolates at armed forces hospital, al-kharaj, saudi arabia, from november, 2004 to october, 2007. a total of 328 isolates of k. pneumoniae recovered from 8152 different specimens were studied for esbl production and antimicrobial susceptibility. the prevalence of ... | 2009 | 19356348 |
| coupling sigma factor conformation to rna polymerase reorganisation for dna melting. | atp-driven remodelling of initial rna polymerase (rnap) promoter complexes occurs as a major post recruitment strategy used to control gene expression. using a model-enhancer-dependent bacterial system (sigma54-rnap, esigma54) and a slowly hydrolysed atp analogue (atpgammas), we provide evidence for a nucleotide-dependent temporal pathway leading to dna melting involving a small set of sigma54-dna conformational states. we demonstrate that the atp hydrolysis-dependent remodelling of esigma54 occ ... | 2009 | 19356588 |
| mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat proteins qnra, qnrb and qnrs. | pentapeptide repeat proteins (prps) qnra, qnrb and qnrs confer reduced susceptibility to quinolones. this study presents an in vitro analysis of the genetic evolution of quinolone resistance mediated by changes in the coding sequences and promoter regions of qnra1, qnrs1 and qnrb1 genes. | 2009 | 19357158 |
| detection of plasmid-mediated kpc-producing klebsiella pneumoniae in ottawa, canada: evidence of intrahospital transmission. | klebsiella pneumoniae isolates from three patients admitted to the ottawa hospital, a 1,040-bed teaching hospital, were found to contain the plasmid-borne k. pneumoniae carbapenemase (kpc)-producing bla gene (bla(kpc)). there was evidence of person-to-person transmission for two patients. screening of 186 clinical isolates revealed no additional bla(kpc)-containing isolates. | 2009 | 19357206 |
| community-acquired urinary tract infections in southern turkey: etiology and antimicrobial resistance. | in this study, we compared the distribution and antibiotic susceptibility patterns of bacterial strains isolated from patients with community-acquired urinary tract infections in southern turkey, hatay, during 2004 and 2005. the majority (82.3%) of the isolates were from women while the remaining (17.7%) were from men. of all samples tested, 49% were culture-positive with a bacterial pathogen. the most frequently isolated bacterial species were escherichia coli (45.1%), coagulase-negative staphy ... | 2009 | 19203547 |
| [collateral damage of cephalosporins and quinolones and possibilities for control]. | background: the occurrence of multidrug-resistant microorganisms is associated with an extended and long-term use of broad-spectrum antibiotics. indeed, this may lead to a colonization and even to an infection of the patient, which is called collateral damage. moreover, the risk for collateral damage can be assessed for different antibiotic classes. occurrence of multidrug-resistant microorganisms: the use of cephalosporins may induce a subsequent infection with vancomycin-resistant enterococci, ... | 2009 | 19242662 |
| does the activity of the combination of imipenem and colistin in vitro exceed the problem of resistance in metallo-beta-lactamase-producing klebsiella pneumoniae isolates? | using time-kill methodology, we investigated the interactions of an imipenem-colistin combination against 42 genetically distinct klebsiella pneumoniae clinical isolates carrying a bla(vim-1)-type gene. irrespective of the imipenem mic, the combination was synergistic (50%) or indifferent (50%) against colistin-susceptible strains, while it was antagonistic (55.6%) and rarely synergistic (11%) against non-colistin-susceptible strains (with synergy being observed only against strains with colisti ... | 2009 | 19258266 |
| genetic organization of transposase regions surrounding blakpc carbapenemase genes on plasmids from klebsiella strains isolated in a new york city hospital. | carbapenem-resistant klebsiella strains carrying klebsiella pneumoniae carbapenemases (kpc) are endemic to new york city and are spreading across the united states and internationally. recent studies have indicated that the kpc structural gene is located on a 10-kb plasmid-borne element designated tn4401. fourteen klebsiella pneumoniae strains and one klebsiella oxytoca strain isolated at a new york city hospital in 2005 carrying either bla(kpc-2) or bla(kpc-3) were examined for isoforms of tn44 ... | 2009 | 19258268 |
| biochemical characterization of the hpxo enzyme from klebsiella pneumoniae, a novel fad-dependent urate oxidase. | the hpxo enzyme from klebsiella pneumoniae was recently proposed, on the basis of genetic studies, to catalyze the hydroxylation of uric acid to 5-hydroxyisourate as part of the purine catabolic pathway. its primary sequence suggests that the hpxo catalytic activity depends on a flavin cofactor (fad), contrasting with all previously studied urate oxidase enzymes, which have no cofactor requirement. here we demonstrate biochemically that hpxo is an fad-dependent urate oxidase. our data are consis ... | 2009 | 19260710 |
| decreased susceptibility to polymyxin b during treatment for carbapenem-resistant klebsiella pneumoniae infection. | 2009 | 19261795 | |
| [evaluation of the microscan negcombo panel type 44 for detection of extended-spectrum beta-lactamase among clinical isolates of escherichia coli, klebsiella species, and proteus mirabilis]. | accurate and rapid detection of extended-spectrum beta-lactamases (esbls) is important in guiding proper antimicrobial therapy for infected patients. we evaluated the performance of microscan negcombo type 44 panel (dade behring, usa), which was developed to confirm esbl-producing enterobacteriaceae using ceftazidime/clavulanate and cefotaxime/clavulanate. | 2009 | 19262076 |
| mwr xer site-specific recombination is hypersensitive to dna supercoiling. | the multiresistance plasmid pjhcmw1, first identified in a klebsiella pneumoniae strain isolated from a neonate with meningitis, includes a xer recombination site, mwr, with unique characteristics. efficiency of resolution of mwr-containing plasmid dimers is strongly dependent on the osmotic pressure of the growth medium. an increase in supercoiling density of plasmid dna was observed as the osmotic pressure of the growth culture decreased. reporter plasmids containing directly repeated mwr, or ... | 2009 | 19359357 |
| infection control challenges in deployed us military treatment facilities. | personnel sustaining combat-related injuries in current overseas conflicts continue to have their care complicated by infections caused by multidrug-resistant organisms, including acinetobacter, klebsiella, and pseudomonas. although presumed to be due to multiple factors both within and outside of the combat theater, concern has been raised about the difficulties in establishing and maintaining standard infection control (ic) practices in deployed medical treatment facilities and in the evacuati ... | 2009 | 19359955 |
| identification and characterization of a bioactive lantibiotic produced by staphylococcus warneri. | lantibiotics are a group of potent antibacterial agents that contain unusual amino acids, such as the thioether amino acids lanthionine and methyllanthionine, and the didehydroamino acids didehydroalanine and didehydro-aminobutyric acid. here, we report on an antibacterial lantibiotic peptide named swlp1 (staphylococcus warneri lantibiotic peptide 1), which is secreted from staphylococcus warneri (deposited with dsmz, accession number dsm 16081). swlp1 was purified from growth media. the purifie ... | 2009 | 19361283 |
| clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing escherichia coli and klebsiella species: a retrospective matched case-control study. | clinical outcomes of spontaneous bacterial peritonitis (sbp) due to extended-spectrum beta-lactamase-producing escherichia coli and klebsiella species (esbl-ek) have not been adequately investigated. | 2009 | 19361340 |
| in vivo pharmacodynamic profile of tigecycline against phenotypically diverse escherichia coli and klebsiella pneumoniae isolates. | tigecycline is a glycylcycline with activity against enterobacteriaceae, including multidrug-resistant isolates of klebsiella pneumoniae and escherichia coli producing extended-spectrum beta-lactamase (esbl) and carbapenemases. herein, we used an in vivo murine thigh model to characterize the pharmacodynamic profile of tigecycline against genotypically and phenotypically diverse k. pneumoniae and e. coli isolates. doses of 3.125 to 300 mg/kg, divided 1 to 6 times daily, were administered subcuta ... | 2009 | 19364850 |
| early- and late-onset pneumonia: is this still a useful classification? | the choice of empirical treatment of nosocomial pneumonia in the intensive-care unit (icu) used to rely on the interval after the start of mechanical ventilation. nowadays, however, the question of whether in fact there is a difference in the distribution of causative pathogens is under debate. data from 308 icus from the german national nosocomial infection surveillance system, including information on relevant pathogens isolated in 11,285 cases of nosocomial pneumonia from 1997 to 2004, were u ... | 2009 | 19364852 |
| high prevalence of qnr genes in commensal enterobacteria from healthy children in peru and bolivia. | a remarkable prevalence of qnrb (54%) and, at a lower level, of qnrs (14%) was discovered in pools of commensal enterobacteria from 310 healthy children living in peru and bolivia, using a metagenomic approach. analysis of randomly selected enterobacterial pools revealed that qnrb was mainly carried by escherichia coli and qnrs by klebsiella pneumoniae. investigation of 11 qnrb-positive isolates and 9 qnrs-positive isolates revealed the presence of plasmid-borne qnrb19 (n = 8), qnrb2 (n = 2), qn ... | 2009 | 19364872 |
| fast detection of bacterial growth by using portable microbe enrichment unit (pmeu) and chempro100i((r)) gas sensor. | the combination of the portable microbe enrichment unit (pmeu) cultivation and chempro100i((r)) chemical detector helps the fast detection of hospital infections. the first alarm of the microbe metabolism and growth in the enrichment culture was achieved in 2-3h when pure cultures of strains isolated from neonatal patients were tested. for the detection of minor concentrations of the bacteria, bacillus, staphylococcus, klebsiella and escherichia strains were diluted to 0.5-600cells per ml. their ... | 2009 | 19369043 |
| bartholin's abscess caused by hypermucoviscous klebsiella pneumoniae. | klebsiella pneumoniae serogroups displaying the hypermucoviscosity phenotype are associated with a distinct clinical syndrome characterized by liver abscesses, bacteraemia and metastatic lesions. we describe here what we believe to be the first reported case of hypermucoviscous k. pneumoniae causing a superficial bartholin's abscess in the absence of systemic involvement. | 2009 | 19369531 |
| cytotoxicity, antimicrobial activity and composition of essential oil from tanacetum balsamita l. subsp. balsamita. | the aerial parts of tanacetum balsamita subsp. balsamita were collected at full flowering stage from tabriz, iran. the essential oil was isolated by hydrodistillation and analyzed by combination of capillary gc and gc-ms. twenty seven components were identified, representing 99.2% of the total oil. carvone (51.0%), beta-thujone (20.8%), 1,8-cineole (4.4%) and alpha-thujone (3.2%) were the main components. the in vitro antimicrobial activity of the essential oil of t. balsamita subsp. balsamita w ... | 2009 | 19370888 |
| a novel neutrophil-specific pet imaging agent: cflflfk-peg-64cu. | the synthesis and validation of a new, highly potent (64)cu-labeled peptide, cflflfk-peg-(64)cu, that targets the formyl peptide receptor (fpr) on leukocytes is described. the peptide ligand is an antagonist of the fpr, designed not to elicit a chemotactic response resulting in neutropenia. evidence for the selective binding of this synthesized ligand to neutrophils is provided. pet properties of the compound were evaluated in a mouse model of lung inflammation. | 2009 | 19372473 |
| antimicrobial activity of flavanoid sulphates and other fractions of argyreia speciosa (burm.f) boj. | antimicrobial activity of flavanoid sulphates and different fractions of a. speciosa root was studied against bacteria, fungi and mycobacterium tuberculosis h37 rv sensitive strain by in vitro and in vivo assays. flavanoid sulphates such as quercetin 3'7 di-o methyl 3- sulphate and kaempferol 7-o methyl 3-sulphate were isolated from the n-butanol fraction of 80% methanolic extract of the plant. the structures of the isolated flavanoids were confirmed by spectral studies. ethyl acetate (eaas) fra ... | 2009 | 19374167 |
| [a model of multiple organ injury induced by klebsiella pneumoniae pneumonia in aged rats]. | to reproduce a model of bacterial multiple organ injury (moi) in aged rats. | 2009 | 19374791 |
| sepsis and lung abscess following malposition of an umbilical vein catheter in a neonate. | umbilical vein catheterisation is a common and useful procedure in the care of critically ill newborns, but several complications may occur. | 2009 | 19263327 |
| fate of the h-ns-repressed bgl operon in evolution of escherichia coli. | in the enterobacterial species escherichia coli and salmonella enterica, expression of horizontally acquired genes with a higher than average at content is repressed by the nucleoid-associated protein h-ns. a classical example of an h-ns-repressed locus is the bgl (aryl-beta,d-glucoside) operon of e. coli. this locus is "cryptic," as no laboratory growth conditions are known to relieve repression of bgl by h-ns in e. coli k12. however, repression can be relieved by spontaneous mutations. here, w ... | 2009 | 19266030 |
| single and simple antibiotic prophylaxis for elective cholecystectomy. | to determine the postoperative infection result after use of a single and simple antibiotics for prophylaxis in open elective cholecystectomy. | 2009 | 19268013 |
| ru(ii) complexes of n4 and n2o2 macrocyclic schiff base ligands: their antibacterial and antifungal studies. | reactions of [rucl2(dmso)4] with some of the biologically active macrocyclic schiff base ligands containing n4 and n2o2 donor group yielded a number of stable complexes, effecting complete displacement of dmso groups from the complex. the interaction of tetradentate ligand with [rucl2(dmso)4] gave neutral complexes of the type [rucl2(l)] [where l=tetradentate macrocyclic ligand]. these complexes were characterized by elemental, ir, 1h, 13c nmr, mass, electronic, thermal, molar conductance and ma ... | 2009 | 19268628 |