Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [diagnostic accuracy of ft3-ria and ft4-ria compared to total t3-ria and total t4-ria]. | the values of ft3-serum concentration (amerlex-ria) from 311 patients and the ft4-values (amerlex-ria) from 745 patients were compared with the total t3- and total t4-values with regard to their diagnostic accuracy in hypo-, eu- and hyperthyroidism. the classification of patients into these three diagnostic categories was determined by the majority of available parameters. the analysis of the predictive values demonstrated that determination of free hormones usually guarantees a safe distinction ... | 1985 | 4000980 |
| [changes in iodine metabolism in patients with burns treated topically with pvp-iodine]. | under exposure treatment of 33 burn patients with povidone-iodine (polyvinylpyrrolidon-iodine) preparations (betaisodona ointment and solution) massive absorption of the iodine by the body and temporary changes in the thyroid hormones (t3 and t4 lowered, tsh raised) were found. no other clinical or laboratory-chemical side effects were observed in the patients. trh stimulation test was carried out on 18 patients 3-6 months after ceasing povidone-iodine application. the results showed normoreacti ... | 1985 | 4002421 |
| clinical and immunologic features of chronic dialysis patients who fail to respond to hepatitis b vaccine. | eighteen patients on chronic dialysis (15 haemodialysis, three peritoneal) were evaluated to determine whether certain clinical features and/or in vitro indicators of immune function correlated with the response to hepatitis b vaccine. only 44% of patients developed antibody to hepatitis b surface antigen (anti-hbs) following vaccination and neither duration of dialysis, history of renal transplant, peripheral t cell numbers, t4/t8 ratios, nor mitogen induced lymphocyte proliferation correlated ... | 1985 | 4002834 |
| subclinical thyroid hormone abnormalities in type i diabetic children and adolescents. relationship to metabolic control. | the serum levels of thyroid hormones and thyroid stimulating hormone were compared in 64 type i diabetic children and adolescents without ketosis and in 28 age matched normal subjects. only t3 levels were significantly different in the diabetic patients (2.38 +/- 0.41 nmol/l) than in controls (2.64 +/- 0.52 nmol/l) (p less than 0.01) confirming the existence of the 'low t3 syndrome' in diabetic children. a negative correlation was found between t3 and blood glucose as well as glycosylated haemog ... | 1985 | 4003063 |
| size of the tumor and other factors influencing prognosis of carcinoma of the head of the pancreas. | extent of the tumor in carcinoma of the pancreas seems an important factor in stage classification. the purpose of this report is to present the results of studies on the relationship between the size of the tumor (t) and prognosis, and the correlation between the size and the other factors influencing prognosis such as invasion to the pancreatic capsule, invasion to the retroperitoneal tissue, metastasis to the regional lymph node, and so on. t was divided into four groups: t1, t2, t3, t4. tumo ... | 1985 | 4003374 |
| feasibility of subtotal laryngectomy based on whole-organ examination. | subtotal (near-total) laryngectomy has recently been advocated to eradicate large laryngeal tumors. the operation, which preserves the cricoarytenoid joint and adjacent vocal fold, is based on the premise that many t3 and t4 tumors can be resected without complete sacrifice of the phonatory mechanism. the purpose of this study was to verify or disprove the assumption by examining sections of whole-organ laryngeal specimens. twenty-four of the 64 specimens analyzed were determined to be resectabl ... | 1985 | 4004632 |
| structural basis for the reaction of 3,5,3'-tri-iodothyronine-specific antibodies with thyroxine-containing thyroglobulin. | a series of human autoantibodies against thyroglobulin (tg) which exhibit different specificities for iodothyronines were studied. the ability of a thyroxine (t4)-containing peptide (t4p) isolated from human thyroglobulin (tg) to displace [125i]t3 from human t3-specific autoantisera was 11-50 times greater than that of t4 alone. these antisera therefore strongly recognize amino acids adjacent to t4 in the tg structure. this was confirmed when a tg preparation (tg[0.05]) containing an average of ... | 1985 | 4004811 |
| [blocking effect of cycloheximide on decreased mitochondrial resistance due to thyroid hormone action]. | administration of cycloheximide (20-25 micrograms/kg bw twice, interval 24 h) to hyperthyroid rats (300 micrograms/t4/100 g bw i. p. 48 h before sacrifice) inhibited the decrease in mitochondrial resistance to ca2+ characteristic of hyperthyroidism. it was established in particular that calcium capacitance of the mitochondria and the time of the maintenance of transmembrane potential of these organelles under calcium loading were increased in the mitochondria of hyperthyroid animals given cycloh ... | 1985 | 4005406 |
| increased pituitary thyroxine 5'-deiodinase activity in adult rats rendered hyper- or hypo-thyroid during perinatal life. | perinatal thyroid dysfunction in the rat leads to permanent alterations in pituitary tsh secretion in the adult animal. thus, neonatal hyperthyroidism (nh) and perinatal hypothyroidism (ph) both result in apparent increased pituitary sensitivity to the feedback effects of thyroid hormones in the adult rat. to determine if increased intrapituitary generation of triiodothyronine (t3) might account for these observations, we measured thyroxine (t4) 5'-deiodinase activity in pituitary homogenates of ... | 1985 | 4005702 |
| increased dihydrotestosterone receptor levels in high-stage renal adenocarcinoma. | primary renal adenocarcinoma tissue, metastatic deposits, and normal kidney parenchyma from 16 patients were assayed for sex hormone receptors by dextran-coated charcoal adsorption and sucrose gradient centrifugation techniques. dihydrotestosterone receptors (dhtr) were found in all renal carcinomatous tissue (20/20) and in 93% (13/14) autologous normal kidneys analyzed. testosterone receptors were found in 84% (16/19) of tumors and 93% (14/15) or normal kidneys analyzed. estrogen receptors in s ... | 1985 | 4005782 |
| [distribution kinetics and metabolism of triiodothyronine and thyroxine in the organs and tissues of mice with transplanted lewis carcinoma]. | a comparative analysis of triiodothyronine (t3) and thyroxine (t4) distribution in organs and tissues of tumour-bearing and intact mice conducted wih 125j labelled t3 and t4 has shown considerable differences in the accumulation character of these hormones in mice with lewis carcinoma and in intact animals in the liver, kidneys, lungs, adrenal glands, lymphatic nodes. low t3 and t4 concentration in the blood of tumour-bearing mice was observed during the whole period of study. | 1985 | 4006849 |
| synthesis and some properties of sulfate esters and sulfamates of iodothyronines. | in the present study, convenient methods have been developed for the synthesis of sulfate derivatives of iodothyronines. reaction with chlorosulfonic acid in dimethylformamide gave rise to formation of the sulfate ester with the phenolic hydroxyl group. reaction with the sulfurtrioxide-trimethylamine complex in alkaline medium afforded the sulfamate with the alpha-amino group of the alanine side chain. the sulfated products were isolated by adsorption onto sephadex lh-20 in acidic medium, follow ... | 1985 | 4006859 |
| freeze fracture morphology of thyroid tight junctions in goats with different thyrotropin stimulation. | in the thyroid follicles and blood of goats with congenital hypothyroidism and goiter, abnormal iodoproteins (e.g. iodoalbumin) are found. to study the mechanism involved in the passage of these proteins between the follicles and the blood, the morphology of tight junctions in goiters and normal thyroids of goats was studied by means of freeze fracturing. the t4 and tsh levels of 16 goats were measured by ria. based on the tsh levels, the goats could be divided into three groups: a euthyroid gro ... | 1985 | 4006860 |
| thyroxine 5'-deiodinase activity in anterior pituitary glands transplanted under the renal capsule in the rat. | the conversion of t4 to t3 by the anterior pituitary gland appears to be of considerable physiological importance in the control of pituitary function. to determine a possible role of hypothalamic factors in controlling this enzymatic process, iodothyronine 5'-deiodinase (i5'd) activity was studied in rats 6 weeks after homologous transplantation of pituitary (implanted animals) or muscle tissue (sham animals) under the renal capsule. intrasellar pituitaries remained intact, and serum t3, t4, an ... | 1985 | 4006866 |
| rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. | previous studies have shown that the inner ring deiodination (ird) of t3 and the outer ring deiodination (ord) of 3,3'-diiodothyronine are greatly enhanced by sulfate conjugation. this study was undertaken to evaluate the effect of sulfation on t4 and rt3 deiodination. iodothyronine sulfate conjugates were chemically synthetized. deiodination was studied by reaction of rat liver microsomes with unlabeled or outer ring 125i-labeled sulfate conjugate at 37 c and ph 7.2 in the presence of 5 mm dith ... | 1985 | 4006868 |
| effect of diabetes on triiodothyronine and reverse triiodothyronine production in the perfused rat liver and kidney. | this study was undertaken to elucidate the effect of diabetes on the conversion of t4 to t3 and rt3 in the isolated, perfused rat liver and kidney. the livers and kidneys from streptozocin (stz)-induced (50 mg/kg i.p. 2 wk before killing) diabetic rats with or without t4 (30 micrograms/kg s.c. daily) treatment were perfused for 30 min with a synthetic medium containing t4 (6 micrograms/dl), and production of t3 and rt3 in the tissues was measured by radioimmunoassay. the production of t3 (111 +/ ... | 1985 | 4007285 |
| localization of thyroxine 5'-monodeiodinase activity in the renal proximal tubules in rabbits and rats. | to determine the localization of t4 5'-monodeiodinase activity in rabbit and rat nephron segments, the formation of tri-iodothyronine (t3) from thyroxine (t4) was measured in kidney homogenate and in isolated nephron segments obtained by the microdissection method. in order of decreasing activity, homogenates of rabbit renal cortex, outer medulla and inner medulla were capable of converting t4 to t3. in the isolated nephron segments of the rabbit cortex, the activities were noted in both proxima ... | 1985 | 4007770 |
| comparison of four methods of calf confinement. i. physiology. | holstein bull calves were blocked by birth order and randomly assigned to one of three treatments in trial i: stall (n = 7), pen (n = 7) and hutch (n = 7), and to one of four treatments in trial ii: stall (n = 6), pen (n = 5), hutch (n = 6) and yard (n = 8). stalls were elevated, .56 x 1.2 m, with wooden slatted floors. stalled calves were tethered from the front with a collar and .5-m chain. pens were elevated, 1.2 x 1.5 m, with wooden slatted floors and were located in the same open-front buil ... | 1985 | 4008357 |
| the effect of glucose deprivation or 2-deoxy-d-glucose on the monodeiodination of thyroxine in human fibroblasts in culture. | the effect of glucose deprivation or 2-deoxy-d-glucose on monodeiodination of t4 to t3 and rt3 was examined in human skin fibroblasts in culture. when the cultured cells were exposed to glucose-free medium containing 1 x 10(-7) m t4 for 48 h, the cellular t4 level was similar to that of cells incubated in medium containing 1 mg/ml glucose. the intracellular t3 level significantly decreased and, in contrast, the intracellular rt3 level markedly increased compared to those levels in control cells. ... | 1985 | 4008605 |
| reversible abnormalities of myocardial relaxation in hypothyroidism. | fifteen selected hypothyroid patients without symptoms or signs of cardiovascular disease and an equal number of matched control subjects underwent simultaneous recording of electrocardiogram and phono-, apex-, and echocardiography to assess dynamic systolic and diastolic left ventricular function. both the systolic preejection period and the isovolumic relaxation period were significantly increased in the hypothyroid group. however, whereas the rate of myocardial contraction, assessed from the ... | 1985 | 4008607 |
| three-dimensional structure of unstained, frozen-hydrated extended tails of bacteriophage t4. | unsupported, unstained frozen-hydrated extended tails of bacteriophage t4 have been studied by cryo-electron microscopy. their three-dimensional structure has been reconstructed after correlation and averaging of the information from different particles. while the reconstructions of hydrated tails show all the features found by conventional electron microscopy, they are characterized by an open structure. individual subunits constituting the axial repeat cannot be outlined unambiguously, as the ... | 1985 | 4009713 |
| effects of chlorine dioxide on thyroid function in neonatal rats. | chlorine dioxide (clo2), an alternative to chlorine for drinking water disinfection, has been implicated as a potential antithyroid agent (bercz et al., 1982). because antithyroid compounds are known to alter neurobehavioral development, the present study was designed to determine if perinatal exposure to clo2 affects behavioral activity in rat pups. the activity cage system was designed to monitor the development of locomotor activity of a litter of pups between ages 14-21 d. pups were exposed ... | 1985 | 4009737 |
| identification of a human hemoglobin tryptic peptide (alpha-t4) from a bloodstain by fast protein liquid chromatography--determination of human origin. | 1985 | 4010053 | |
| the effects of acute and chronic treatment with triiodothyronine and thyroxine on the hypothalamic and telencephalic catecholamine nerve terminal systems of the hypophysectomized male rat. chronic treatment modulates catecholamine utilization in discrete catecholamine nerve terminal systems. | using catecholamine (ca) fluorescence histochemistry in combination with quantitative microfluorimetry, it has been shown that chronic treatment with triiodothyronine (t3) and thyroxine (t4; 2 x 10 and 2 x 36 micrograms/kg i.p., respectively, twice daily for 10 days), but not acute treatment (1 and 3.6 mg/kg i.p., respectively, 2 h before killing), increases ca utilization in the medial and lateral palisade zones of the median eminence and reduces noradrenaline (na) utilization in the parvocellu ... | 1985 | 4010888 |
| endocrine changes in the fowl during infection with eimeria maxima. | plasma concentrations of thyroxine (t4), triiodothyronine (t3), prolactin, growth hormone and corticosterone were measured in immature domestic fowl which were infected with eimeria maxima, uninfected but given the same amount of food as those infected (pair-fed) or fed ad libitum. infection with e maxima caused a decrease in plasma t4 concentration whereas pair feeding caused an increase when food intake was minimal. plasma t3 concentrations were decreased similarly in both infected and pair-fe ... | 1985 | 4012033 |
| ct in determining the depth of infiltration of bladder tumors. | the findings from 141 ct investigations of bladder tumors are compared with histopathological staging (103 cases) and clinical staging (36 cases). twenty-five tumors could not be seen on ct and 2 tumors could not be staged because of artifacts caused by hip prosthesis. when the tumor was visible at ct and there was histological confirmation of the depth of the infiltration, we were able to differentiate extravesical tumor stages t3b and t4 from each other and from all the other stages in 49 of 5 ... | 1985 | 4012932 |
| enhanced thermogenic responsiveness during chronic ephedrine treatment in man. | the thermogenic effect of a single oral dose of ephedrine (1 mg/kg body weight) was studied by indirect calorimetry in five women with 14% overweight before, during and 2 mo after 3 mo of chronic ephedrine treatment (20 mg, perorally, three times daily). before treatment and 2 mo after its cessation a similar thermogenic response to ephedrine was observed. the total extra consumption of oxygen was 1.3 1 before and 1.2 1 after cessation of the chronic treatment. after 4 and 12 wk of treatment eph ... | 1985 | 4014068 |
| antithyroid antibodies in depressed patients. | the presence of antithyroid (antimicrosomal and antithyroglobulin) antibodies was assessed in 45 psychiatric inpatients with prominent depressive symptoms (28 with dsm-iii major depression). nine patients (20%) had detectable titers of antithyroid antibodies, a rate considerably higher than the 5%-10% observed in the normal population. each of these nine patients with symptomless autoimmune thyroiditis had normal baseline serum thyrotropin concentrations and normal thyroid function (as assessed ... | 1985 | 4014506 |
| blunt chest trauma and suspected aortic rupture: reliability of chest radiograph findings. | the chest radiographs of 86 patients with suspected aortic rupture from blunt chest trauma were reviewed. seventy-three patients had no evidence of aortic rupture on aortography or surgical exploration, and 13 patients had surgically confirmed rupture. sixteen radiographic findings were analyzed for sensitivity and specificity in detecting aortic rupture. the following findings were not statistically significant: hemothorax on either side; rib fractures on either side; pneumothorax on either sid ... | 1985 | 4014812 |
| effects of d- and l-thyroxine on the glucocorticoid binding capacity of adult rat liver. | administration of either d- or l-thyroxine (t4) significantly increased the glucocorticoid binding capacity of cytosol of the livers of adrenalectomized adult rats. administration of up to 0.5 mg/100 g body wt. of l-t4 was more effective than that of d-t4, but higher doses (0.8-3 mg/100 g body wt.) of d-t4 increased the binding capacity markedly to more than that with l-t4. t4- administration did not alter the apparent dissociation constant of glucocorticoid binding proteins for glucocorticoid b ... | 1985 | 4015640 |
| proton nuclear magnetic resonance assignments of thyroid hormone and its analogues. | 1h nmr data of a series of thyroid hormone analogues, e.g., thyroxine (t4), 3,5,3'-triiodothyronine (t3), 3,3',5'-triiodothyronine (rt3), 3,3'-diiodothyronine (3,3'-t2), 3,5-diiodothyronine (3,5-t2), 3',5'-diiodothyronine (3',5'-t2), 3-monoidothyronine (3-t1), 3'-monoiodothyronine (3'-t1), and thyronine (to) in dimethylsulfoxide (dmso) have been obtained on a 300 mhz spectrometer. the chemical shift and coupling constant are determined and tabulated for each aromatic proton. the inner tyrosyl ri ... | 1985 | 4015673 |
| [action of thyroxine on the cytochrome content in the brain and liver mitochondria during the postnatal development of rats]. | the content of cytochromes c + c1, b and a in brain and liver mitochondria in 7-day-old rats reaches the level seen in adult animals. administration of l-t4 in a dose of 0.7 micrograms/g rat bw for 4 days before sacrifice results in activation of cytochrome synthesis in both test organs within the first week of the suckling rats' life. on the 20th day of the postnatal period the effect of t4 is seen only in the liver while the brain tissue turns out indifferent to the thyroid hormone. thus, t4 a ... | 1985 | 4016261 |
| primary lymphomas of the nasal cavity and paranasal sinuses. | extranodal lymphomas which present in the nasal cavity and/or the paranasal sinuses are rare. thirty-eight patients with disease that was clinically limited to the head and neck (ann arbor stages ie-iie) were admitted between 1947 and 1983. twenty-eight patients were treated with radiotherapy alone and 10 received combination chemotherapy in addition. the overall 5-year survival figure was 56%. the corresponding result for stage ie was 67%. no patient with stage iie disease survived 5 years. ext ... | 1985 | 4016673 |
| phosphate buffer and salt medium concentrations affect the inactivation of t4 phage by platinum(ii) complexes. | the initial rate of inactivation of t4 phage by solutions of [pt(nh3)2cl2], [ptencl2] and [pten(h2o)2] (no3)2 at fixed values of ph is strongly reduced by phosphate buffer, slightly reduced by acetate buffer and apparently not influenced by bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane (bis-tris) buffer and hepes buffer. the phosphate abolishes the antiphage activity of the platinum complexes probably by some sort of complex formation. this together with dimerization reactions qualitatively ... | 1985 | 4017101 |
| 'chemical hyperthyroidism': the significance of elevated serum thyroxine levels in l-thyroxine treated individuals. | we have previously reported that l-thyroxine treated patients may often have elevated serum t4 concentrations and yet show no clinical signs of hyperthyroidism. we found that such patients had normal serum t3 concentrations. the present study explored the relationship between serum t3 and t4 and dosage of l-thyroxine. retrospective analysis of 99 patient records was performed. there was an increase of serum t4, serum t3 resin uptake (t3r), and t3 with increasing dose of l-thyroxine. the t3/t4 ra ... | 1985 | 4017260 |
| [behavior of several hormonal and nonhormonal parameters in obesity. ii. thyroid hormones (free t3, free t4, rt3)]. | 1985 | 4017497 | |
| thyroid hormones increase renal brush border membrane transport of phosphate in x-linked hypophosphatemic (hyp) mice. | hyp mice, the murine homolog of human x-linked hypophosphatemia (xlh), are characterized in part by elevated renal loss of phosphate (pi) and hypophosphatemia. the lesion responsible for this syndrome is believed to be defective na+ gradient-dependent phosphate transport across renal brush border membranes (bbm). it has been demonstrated that thyroid hormones can stimulate pi uptake by rat bbm vesicles (bbmv). the purpose of this current study was to determine whether thyroid hormones could incr ... | 1985 | 4017950 |
| hormonal changes in burned hamsters. | burned male syrian hamsters (burn size 23% of body surface) exhibited reduced total (t4) and free (ft4) serum concentrations, a defect in t4 binding to serum proteins manifested by the t4 dialyzable fraction but not the in vitro t3 charcoal uptake, and reduced serum testosterone concentration. these changes are similar to those noted previously in burned humans. unlike such patients, burned hamsters did not exhibit reduced serum t3 nor elevated rt3 concentrations in a reproducible manner. pineal ... | 1985 | 4017958 |
| concentrations of thyroxine and 3,5,3'-triiodothyronine at 34 different sites in euthyroid rats as determined by an isotopic equilibrium technique. | the present study was designed to assess the quantities of t4 and t3, and the source (i.e. plasma-derived vs. locally produced) of the latter iodothyronine, in various rat tissues. for this purpose, normal intact rats were brought to isotopic equilibrium by means of a continuous iv infusion of [125i]t4 and [131i]t3 for a prolonged period. at the end of the infusion period, the animals were bled and perfused. either whole small organs or weighed portions of tissues were homogenized in saline. the ... | 1985 | 4017962 |
| production of anti-human thyroglobulin and anti-thyroid hormone antibodies in rabbits immunized with human thyroglobulin. | two rabbits (tg-1, tg-2) were immunized with human thyroglobulin (htg) and bled serially. antisera were obtained at different times after the first immunization and kept separately and studied. in both rabbits production of anti-htg, and anti-thyroid hormone antibodies such as anti-thyroxine (t4) and anti-triiodothyronine (t3) antibodies was observed. binding parameters of anti-htg antibodies with htg, t4, and t3 were calculated in two selected antisera (70-day and 249-day). the scatchard's plot ... | 1985 | 4017976 |
| effects of cadmium ingestion and food restriction on energy metabolism and tissue metal concentrations in mallard ducks (anas platyrhynchos). | the single and combined effects of cadmium ingestion and food restriction were examined in a 42-day experiment with male, juvenile mallard ducks. a 2 x 3 factorial design was employed consisting of two levels of food supply (ad libitum and 55% of ad libitum intake) and three levels of cadmium in the food (0, 5, or 50 micrograms cd/g food). cadmium ingestion alone had no effect on body or tissue weights, liver glycogen, plasma concentrations of glucose, urea, uric acid, nonesterified fatty acids ... | 1985 | 4017995 |
| genes 55, alpha gt, 47 and 46 of bacteriophage t4: the genomic organization as deduced by sequence analysis. | the nucleotide sequence of t4 genes 55, alpha gt, 47 and 46 was determined by a combination of 'classical' procedures and a shotgun approach. small dna fragments generated by frequent cleavage with restriction enzymes or by sonication of restriction fragments were cloned in phage m13 vectors and sequenced by the dideoxy method. the positions of the genes were determined by marker rescue between the corresponding t4 amber mutants and the cloned t4 dna fragments used in the sequencing experiments. ... | 1985 | 4018026 |
| the amino acid sequence of wheat histone h2a(1). a core histone with a c-terminal extension. | the complete amino acid sequence (145 residues) of histone variant h2a(1) from wheat germ triticum aestivum cultivar t4 has been established from edman degradation of large overlapping fragments. the sequence of histone variant h2a(1) differs from the homologous calf histone in 61 amino acid positions. these differences include an extension of h2a(1) by 19 amino acids at its carboxyl end. | 1985 | 4018096 |
| distribution of 125i-thyroxine in different organs and tissues of dietically obese rats. | the distribution of 125i-thyroxine (% dose/g tissue; tissue/plasma radioactivity ratio) was investigated in different tissues of 28-week-old obese wistar rats. obesity was induced by high-fat diet (hfd) and confirmed by carcass analysis; in heavy obese animals the relative and absolute fat content is increased twofold and threefold, respectively, compared to control rats fed on a low-fat diet (lfd). heavy hfd rats exhibit diminished 125i-t4 distribution in the "slow pool" (fat tissue, muscle) an ... | 1985 | 4018159 |
| [an epidemiological study of subacute thyroiditis in northern japan]. | it is difficult to study subacute thyroiditis epidemiologically since it occurs sporadically and infrequently. information about 1,127 cases (108 males, 1,019 females, from 1967 to 1982) of subacute thyroiditis in northern japan was obtained through a questionnaire. it was found that the usual age for the disease was forty, that females predominated in a ratio of 10.6:1, and that the prevalent month was july. in clinical features, the frequencies of the inflammatory symptoms were high in the acu ... | 1985 | 4018309 |
| effects of dietary thyroid hormones on growth, plasma t3 and t4, and growth hormone in normal and hypothyroid chickens. | cockerels and pullets fed with t3 or t4 for 2 weeks showed a decrease in both body weight gain and feed efficiency. the reduction in body weight gain and feed efficiency was dose related in cockerels where t3 or t4 were fed at 0.1, 1.0, and 10.0 ppm levels. t3 and t4 at 0.1 and 1.0 ppm had no significant effects on growth or feed efficiency in pullets, but the 10.0-ppm level of t3 and t4 caused a reduction of -55.24 and -28.18%, respectively, in body weight gain as compared with control birds. t ... | 1985 | 4018556 |
| seasonal changes in t3, ft4, and cortisol in free-ranging svalbard reindeer (rangifer tarandus platyrhynchus). | serum levels of 3,5,3'-triiodothyronine (t3), free thyroxine (ft4), and cortisol were determined for free-ranging svalbard reindeer during winter (march), summer (june-july), and autumn (october). a total of 48 animals representing adult males, adult barren, pregnant, and lactating females, and calves were shot, and blood sampled from their hearts. t3 and ft4 were found to vary seasonally, the levels being lower in winter than in summer or autumn. differences due to state of pregnancy, sex, or a ... | 1985 | 4018559 |
| changes in plasma concentrations of thyroxine and triiodothyronine in beef steers fed different levels of propylthiouracil. | three latin-square trials were conducted to determine the effects of feeding the thyroid depressant propylthiouracil (ptu) on plasma concentrations of thyroxine (t4) and triiodothyronine (t3) in feedlot steers. in trial 1, four steers were fed 0, 1, 2 or 4 mg ptu/kg body weight daily during five 35-d experimental periods. in trial 2, eight steers were fed 0, .5, 1 or 2 mg ptu/kg body weight daily during five 28-d periods. in trial 3, three steers were fed 0, 1 or 4 mg ptu/kg body weight daily du ... | 1985 | 4019339 |
| immune responses during human schistosomiasis mansoni. xi. immunologic status of patients with acute infections and after treatment. | sixteen patients, 8 to 30 yr of age, with acute (toxemic) phase schistosomiasis mansoni were studied immunologically within 2 to 3 mo of their exposure to schistosoma mansoni cercariae, and were monitored after chemotherapy. total leukocyte levels and peripheral blood eosinophilias were higher in these patients than in similar individuals with chronic schistosomiasis mansoni. in contrast to chronic patients, the eosinophilias of the acute cases were decreased rather than elevated upon treatment. ... | 1985 | 4020142 |
| a novel method for the detection of variation in solid-phase immobilised antibody concentration and its possible application in quality control in immunoassay. | variation of solid-phase antibody concentration could give rise to poor intra- and interassay precision. a new method to detect this variation is reported. pooled sera with thyroxine (t4) values at the low, medium, and high ranges were assayed in duplicate using anti-t4-coated polystyrene beads. the antigen-antibody complexes were dissociated with methanol-water mixture and the antibodies re-used for subsequent t4 assays in which the same beads were used with the same set of standards and pooled ... | 1985 | 4020145 |
| [amniotic fluid 3,3',5'-triiodothyronine (reverse t3)]. | rt3(3,3',5'-triiodothyronine) levels in amniotic fluid and t4(thyroxine), t3(triiodothyronine), rt3 and tsh(thyroid-stimulating hormone) levels in maternal and cord serum were determined simultaneously by ria. we also determined the activities of the monodeiodination of thyroxine to rt3 in placentas. amniotic fluid rt3 and cord serum rt3 levels decreased, but t4, t3 and tsh levels increased with advancing gestational age. the activities of the monodeiodination in placentas decreased rapidly from ... | 1985 | 4020201 |
| iodothyronine kinetics in the rabbit: an experimental model. | turnover studies of thyroxine (t4), 3,5,3'-tri-iodothyronine (t3) and 3,3',5'-tri-iodothyronine (rt3) have been performed in the rabbit. a novel modification of a conventional radioimmunoassay has been used to measure specific 125i-labelled iodothyronines in small volumes of plasma in the presence of other 125i-labelled metabolites. kinetic analysis of plasma disappearance of tracer was performed by a new theoretical approach. for t4 the mean (+/- s.d.) plasma concentration, clearance and produc ... | 1985 | 4020315 |
| assembly-dependent conformational changes in a viral capsid protein. calorimetric comparison of successive conformational states of the gp23 surface lattice of bacteriophage t4. | inter- and intra-subunit bonding within the surface lattice of the capsid of bacteriophage t4 has been investigated by differential scanning calorimetry of polyheads, in conjunction with electron microscopy, limited proteolysis and sodium dodecyl sulfate/polyacrylamide gel electrophoresis. the bonding changes corresponding to successive stages of assembly of the major capsid protein gp23, including its maturation cleavage, were similarly characterized. the uncleaved/unexpanded surface lattice ex ... | 1985 | 4020864 |
| auditory brain stem response in experimentally induced hypothyroidism in albino rats. | in order to elucidate the relationship between the auditory function and the thyroid state, experiments were designed to study the effect of hypothyroidism on the onset of auditory brain stem response (abr) in 26 adult myxedematous albino rats. a state of hypothyroidism was induced by daily oral administration of 6-n-propyl-2-thiouracil (ptu). in 23 out of 26 rats we found minor changes in the amplitudes of all abr waves without any correlation with the rats' t4 variation. we noted a conspicuous ... | 1985 | 4021693 |
| distribution and release of immunoreactive thyroid-stimulating hormone in the rat hypothalamus: effects of thyroidectomy, hypophysectomy and treatment with thyroid hormones. | immunoreactive thyroid-stimulating hormone (ir-tsh) has been detected in the hypothalamus and is released in vitro by a calcium-dependent mechanism when the tissue is depolarized. recently, immunocytochemical studies have revealed that ir-tsh is present in thyrotropes in the pars tuberalis. therefore, because these thyrotropes are associated with the median eminence, the area with the highest concentration of ir-tsh, it is of interest to determine if 'hypothalamic' ir-tsh is from neural or pitui ... | 1985 | 4022260 |
| segmental distribution of afferent fibres in the left inferior cardiac nerve of the cat studied by anterograde transport of horseradish peroxidase. | the segmental projection of afferent fibres in the left inferior cardiac nerve of the cat was studied by using the anterograde transport of horseradish peroxidase (hrp). hrp-positive cell bodies were detected in ipsilateral dorsal root ganglia from segments t1 to t7. no labelled neurones were found at segments c8 and t8. the total number of labelled neurones ranged from 157 to 535 neurones in individual experiments. the majority of neurones (70-88%) were localized in the dorsal root ganglia of s ... | 1985 | 4022447 |
| [course of serum levels of free thyroid hormones in children from 10 days to 2 years of age]. | we have been studying a population of 95 normal children aged 10 days to 2 years, in order to determine the normal values of free thyroid hormone in this class of age. the concentrations were measured by radioimmunoassay (lepetit system). free t3 (ft3) appears remarkably stable, with a mean at 4,92 pg/ml (3,23 - 7,50 mg/ml at +/- 2sd). these concentrations are significantly higher than those of adult. free t4 (ft4) shows a significant decrease over the first month of life, with a mean at 14,31 p ... | 1985 | 4022714 |
| [results following gastrectomy and its relation to tumor stage in stomach cancer]. | 88 patients suffering from gastric cancer underwent total gastrectomy. the late results were clearly dependent on the stage of the tumour. in cases of stage t1 and t2 the 5 years survival rate amounted to 86%, in cases of t3 and t4 however, only to 4%. in cases of m0 50% of these patients lived longer than 5 years, in patients with lymphatic spread this percentage came up to 8.7 only. the postsurgical mortality rate was 19.3 on an average with an increase in larger tumours. for improving the pro ... | 1985 | 4024767 |
| lymphocyte phenotype and function in chronically transfused children with sickle cell disease. | immunologic studies were performed on mononuclear cells from ten chronically transfused children with sickle cell disease, and the results were compared with those from five other groups: 21 sickle cell patients who were not receiving regular transfusions, 6 chronically transfused children with other forms of refractory anemia, 10 previously splenectomized children, 5 boys with hemophilia a, and 27 normal adult controls. the helper:suppressor t cell ratios (t4:t8) in all groups except hemophilia ... | 1985 | 4025320 |
| response of the medullary thick ascending limb to hypothyroidism in the rat. | hypothyroidism in the rat is associated with a decrease in kidney size and weight. we have shown previously that this decrease involves all nephron segments in the cortex and outer medulla and is especially pronounced in the medullary thick ascending limb (mtal). therefore, the present study was undertaken for examination of the effect of hypothyroidism on the ultrastructure of the rat mtal. hypothyroidism was induced by feeding aminotriazole (atz), 0.5 g/kg of food, for 4 weeks. a second group ... | 1985 | 4025510 |
| regulation of iodothyronine 5'-deiodination in lean and obese (ob/ob) mice. | obese (ob/ob) mice exhibit impaired cold- and diet-induced thermogenesis, which may result in part from a defect in thyroid hormone action at the level of peripheral deiodination of thyroxine (t4) to 3,5,3'-triiodothyronine (t3). the latter possibility was examined by comparing kinetic parameters of 5'-deiodination (5'-d) in hepatic and renal microsomes of lean and obese mice during various physiological conditions. 5'-d was adaptive to changes in age (1 to 8-10 wk), environmental temperature (1 ... | 1985 | 4025542 |
| [aortofemoral bifurcation bypass--effect of anesthesia procedure (nla, thoracic continuous catheter peridural anesthesia) on circulation, respiration and metabolism. hemodynamic changes caused by peridural anesthesia and anesthesia induction]. | in 50 patients scheduled for infrarenal aortic bypass surgery the cardiovascular effects of two anaesthetic regimes were investigated prior to surgery. a swan-ganz-catheter was used for haemodynamic measurements. these patients, having been randomized into two groups, were optimally volume loaded (pcwp 10 mmhg) before anaesthesia. in 24 patients a thoracic epidural was induced with 12-15 ml 0.25% plain bupivacaine. when segmental anaesthesia had extended from t4/5 to l1/2 general anaesthesia was ... | 1985 | 4025792 |
| the aging thyroid. thyroid deficiency in the framingham study. | in an unselected population of elderly (over age 60 years) men and women (the original cohort of the framingham study), the prevalence of thyroid deficiency, evidenced by a clearly elevated serum thyrotropin (tsh) level (greater than 10 microu/ml), was 4.4%. women had thyroid deficiency (5.9%) more often than men (2.3%). of those with clearly elevated serum tsh levels, only 39% had low serum thyroxine (t4) levels; the remainder had serum t4 levels in the lower half of the normal range. others (5 ... | 1985 | 4026469 |
| medullary space involvement in laryngeal carcinoma. computed tomographic demonstration. | the identification of cartilage involvement in laryngeal carcinoma implies advanced stage t4 disease. although computed tomography (ct) provides the most accurate method of assessing these cartilages, subtle cartilage invasion may go undetected. the major pitfall in detecting tumor involvement is the incomplete calcification of these structures, which may simulate cartilage destruction. high-resolution ct now allows the evaluation of the medullary space of these cartilages. the ct finding of abn ... | 1985 | 4026666 |
| flow cytometric analysis of dna content in human bladder tumors and irrigation fluids. | flow cytometry (fcm) was used to study the dna distribution of 99 tumor biopsy specimens and 41 bladder irrigation samples from patients with transitional cell carcinoma of the bladder. for tumor biopsy and cystectomy specimens, the frequency of aneuploidy increased with advancing tumor stage and grade. all t0 tumors were diploid. twenty-seven percent of t1, 71.4% of t2, and 75% of t3 and t4 tumors were aneuploid. all grade i tumors were diploid. thirty percent of grade ii and 76.9% of grade iii ... | 1985 | 4027899 |
| relationship between serum thyroglobulin and intrathyroidal stable iodine in human simple goitre. | serum thyroglobulin levels are increased in many patients with simple goitre. this increase has been attributed to the release of thyroglobulin (tg) from the colloid of necrosed follicles. to test the hypothesis that increased serum tg could be related to the low intrathyroidal iodine concentration [i], the main cause of nontoxic goitre, these two variables were measured in 91 euthyroid goitrous patients and compared to serum free t3 and free t4 levels as well as thyroid weight. thyroid iodine c ... | 1985 | 4028462 |
| [3-dimensional organization of the basal plate of phage t4 in the star configuration]. | 1985 | 4028950 | |
| effect of thyroid hormone supplementation on survival after bacterial infection. | during nonthyroidal illness in man and a number of experimental animals, serum total thyroid hormone levels are decreased. to determine whether the reduction in thyroid hormones that occurs during nonthyroidal illness is beneficial or harmful to the host, an experimental animal model was developed. male sprague-dawley rats were infected with streptococcus pneumoniae type i, a known human pathogen. by 40 h after inoculation, serum total and free t4 and total t3 decreased significantly. serum free ... | 1985 | 4029085 |
| free thyroxine measurement by one-step method in the plasma of treated and untreated hypothyroid infants. | the one-step radioimmunoassay of free thyroxine (f-t4) using a gamma-coated kit was used in this study. in controls the mean plasma levels (pmol/l) were 20.8 (range 13.5-37) during the first days of life, 17.4 (11.5-27) from 1 week to 1 year, and 17.0 (10-24.5) after 1 year. in preterm newborns it was correlated with the length of gestation. among 23 untreated hypothyroid infants aged 15-22 days, f-t4 was undetectable in those with athyreosis, while in cases with dysgenetic thyroid it was variab ... | 1985 | 4029879 |
| subset specificity of lupus antilymphocyte antibodies studied by two-colour microfluorimetry. | subset specific lymphocytotoxic activity of lupus sera was studied by a combination of selective immunofluorescence labelling and complement-mediated lysis. most frequently death of b cells was detected. many of the sera caused lysis of t lymphocytes; selective cytotoxicity against suppressor t cells could be observed less frequently. all the anti-t4, anti-t8 and anti-b lymphocyte antibodies proved to be cold reactive. | 1985 | 4030025 |
| [infratemporal approach in nasopharyngeal cancer: operative technics and initial results]. | when nasopharyngeal cancer recurs after radiotherapy, and when the dura is not invaded, radical excision is still possible by means of the infratemporal fossa approach (itfa), developed by the senior author. in an effort to improve the results of radiotherapy, 13 cases of residual or persistent disease were operated on by this approach between 1977 and 1981. of seven patients with t4 tumours, all died of persistent disease within two to three years. six patients with t1 or t2 non-keratinizing sq ... | 1985 | 4030414 |
| the binding of a thyroid hormone metabolite, 3-monoiodo-l-thyronine, to bovine serum albumin as measured by circular dichroism. | the interaction between a thyroid hormone metabolite, 3-monoiodo-l-thyronine (3-t1) and bovine serum albumin (bsa) was investigated by using the cd method. an enhanced cd band was observed at the absorption wavelength region of 3-t1 around 293 nm suggesting the binding of 3-t1 to the bsa molecule. the ellipticity at 293 nm was measured at various molar ratios of 3-t1 to bsa, and the apparent binding constant and the maximum number of binding sites could be estimated as kapp = 8.85 +/- 1.07 x 10( ... | 1985 | 4030725 |
| serum ferritin as a marker of thyroid hormone action on peripheral tissues. | serum ferritin measurements were evaluated as a marker of thyroid hormone action on peripheral tissues. mean serum ferritin concentrations were not significantly different in euthyroid, thyrotoxic, and hypothyroid subjects due to a wide spread in ferritin levels among individuals. intraindividual changes in serum ferritin, however, occurred with changing thyroid function. all 18 patients with thyrotoxic graves' disease had a decrease in serum ferritin levels when they became euthyroid during ant ... | 1985 | 4031012 |
| hepatic bioavailability of thyroxine and testosterone in familial dysalbuminemic hyperthyroxinemia. | the bioavailability of [125i]t4 or [3h]testosterone in serum obtained from normal subjects and from subjects with familial dysalbuminemic hyperthyroxinemia (fdh) was studied with a portal vein injection technique in ketamine-anesthetized rats. in the present studies this technique was modified by performing uptake measurements in the presence of serum loaded with either 25 microm t4 or 1 microm testosterone. loading of serum with these high concentrations displaced the labeled hormone from the l ... | 1985 | 4031018 |
| substrate cycling between gluconeogenesis and glycolysis in euthyroid, hypothyroid, and hyperthyroid man. | substrate, or futile cycles, have been hypothesized to be under hormonal control, and important in metabolic regulation and thermogenesis. to define the role of thyroid hormones in the regulation of substrate cycling in glycolysis and gluconeogenesis, we measured rates of cycling in normal (n = 4), hypothyroid (n = 5), and hyperthyroid (n = 5) subjects employing a stable isotope turnover technique. glucose labeled with deuterium at different positions (2-d1-, 3-d1-, and 6,6-d2-glucose) was given ... | 1985 | 4031071 |
| metabolic effect of 3,3',5'-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. evidence for a unique mechanism of thyroid hormone action. | physiologic levels of 3,3',5'-triiodothyronine (rt3) are generally believed to have minimal metabolic effects in the pituitary gland and other tissues. in the present studies, the regulatory role of rt3 and other thyroid hormones on iodothyronine 5'-deiodinase (i5'd) activity was studied in a growth hormone-producing rat pituitary tumor cell line (gh3 cells). i5'd activity was thiol-dependent and displayed nonlinear reaction kinetics suggesting the presence of two enzymatic processes, one having ... | 1985 | 4031075 |
| horseradish peroxidase localization of the sympathetic postganglionic neurons innervating the cat heart. | the localization of the sympathetic postganglionic neurons innervating the cat heart has been investigated by using retrograde axonal transport of horseradish peroxidase (hrp). hrp was injected into the subepicardial layers of 4 different cardiac regions. the animals were sacrificed 72-96 h later and fixed by perfusion via the left ventricle. the paravertebral sympathetic ganglia from the superior cervical, middle cervical and stellate ganglia to t10 ganglia were removed and processed for hrp id ... | 1985 | 4031361 |
| radiation dosimetry of radioiodinated thyroid hormones. | a physiologically based compartmental model for t4 and t3 metabolism in man was used to generate time-activity curves for residence of radioiodine in key organs. t4 and t3 labeled with 123i, 124i, 125i, and 131i were studied. conditions modeled included radioactive iodine uptake (raiu) values of 0%, 1%, 5%, 15% and 25%, and raiu of 15% combined with various degrees of pharmacologic block of thyroidal raiu. using the mird "s" tables, rad doses were generated for each condition. while the shapes o ... | 1985 | 4032047 |
| completion of schistosoma mansoni life cycle in thyroidectomized rats and effects of thyroid hormone replacement therapy. | the survival and maturation of schistosoma mansoni worms was analyzed in normal, thyroidectomized (thyrox), and hormone-restored thyrox rats. restoration therapy was conducted with both t3 and t4; weight gain of treated rats was monitored to assess hormone-replacement efficacy. worm yields, lengths, and sex-ratios were compared. egg yields and the capacity of miracidia to hatch from eggs were also analyzed. the results of these studies support the conclusion that the sequence of steps leading to ... | 1985 | 4032149 |
| thyroid, bradycardic and hypothermic effects of perfluoro-n-decanoic acid in rats. | a single ip injection of perfluoro-n-decanoic acid (pfda) to male wistar rats resulted in an initially rapid, then gradual decrease in food consumption and a parallel loss of body weight. body temperatures and resting heart rates were significantly depressed by pfda treatment. as early as 12 h following a single dose of pfda, serum thyroxine (t4) levels were significantly reduced and remained depressed throughout the 8 day study. serum triiodothyronine (t3) was reduced by 35% 12 h following pfda ... | 1985 | 4032495 |
| full-dose irradiation for patients with invasive bladder carcinoma: clinical and histological factors prognostic of improved survival. | we reviewed the outcome of 55 patients treated from 1974 to 1982 by full-dose radiation therapy (6,400 to 6,800 rad) to identify factors associated with tumor radioresponsiveness and patient cure. all patients had histological proof of muscle invasion by tumor. of the patients 8 (14 per cent) had clinical stage t2, 29 (53 per cent) stage t3 and 18 (33 per cent) stage t4 disease. thirteen patients are alive, all but 2 without evidence of cancer. survivors include 1 of 9 patients who underwent sal ... | 1985 | 4032570 |
| 3-aminobenzamide sensitizes cultured chinese hamster cells with bromodeoxyuridine-substituted dna to genetic damage induced by long-wave uv. | chinese hamster cells, containing brdurd-substituted dna, were irradiated in the presence of 3-aminobenzamide with short-wave uv, long-wave uv or x-rays and analyzed for induced sces or chromosomal aberrations. the data presented in this paper show that when brdurd-substituted cells are irradiated with lw-uv in the presence of 3-aminobenzamide, genetic damage is increased. biochemical analysis shows that the molecular weight of brdurd-substituted dna is reduced by this treatment. the sensitizati ... | 1985 | 4033673 |
| thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat. | cardiovascular alterations in hypo- and hyperthyroidism have been ascribed to changes of noradrenergic neurotransmission. in the present study the influence of thyroid hormones on adrenoceptors in the rat heart was further characterized. the effect of artificial hypothyroidism (induced by feeding 6-propyl-2-thiouracil, ptu) and hyperthyroidism (induced by daily injections of triiodothyronine, t3) on myocardial adrenoceptor binding, catecholamines, some physiological responses, and their interdep ... | 1985 | 4033808 |
| cassava is not a goitrogen in mice. | to examine the effect of cassava on the thyroid function of mice, we fed fresh cassava root to mice and compared this diet with low iodine diet and purina. cassava provided a low iodine intake and increased urine thiocyanate excretion and serum thiocyanate levels. mice on cassava lost weight. the thyroid glands of mice on cassava were not enlarged, even when normalized for body weight. the 4- and 24-hr thyroid uptakes of mice on cassava were similar to those of mice on low iodine diets. protein- ... | 1985 | 4034537 |
| the transition from a fixed ratio to a fixed interval schedule of reinforcement in hypo and hyperthyroid rats. | the modification of behavior caused by hypo and hyperthyroidism were studied when the schedule of reinforcement was changed from a fixed ratio to a fixed interval. the conditions of hypo and hyperthyroidism were obtained with a chronic administration of methimazole and of 1-thyroxine. the level of the modifications of thyroid activity was determined by evaluation of the basal metabolic rate and of the plasma levels of t4. hyperthyroidism caused no modification of the rat behaviour. a difficulty ... | 1985 | 4034628 |
| painful muscle spasm reversed by magnesium sulphate. a case report. | a 25-year-old paraplegic man who had sustained a t3/t4 vertebral compression fracture 3 years previously presented with severe, painful spasm of the left hamstring muscle group of 2 hours' duration. this spasm produced extreme knee flexion of a degree which held the left foot posterior to the right buttock. an intravenous injection of 2 g magnesium sulphate produced immediate relief. possible mechanisms of action of magnesium are discussed. | 1985 | 4035497 |
| prevention of the eye closure defect in lgml/lgml fetal mice by thyroxine. | the open-eye birth defect of mice caused by the lgml mutation was prevented by prenatal administration of thyroxine (t4) to the pregnant mother. treatment on days 10 to 11 of gestation was most effective in preventing open-eyes. a contrasting worsening of the defect was seen after treatment on day 14 of gestation. a dose-response relationship for prevention appeared to be present up to a dose of 0.1 mg/mouse, after which 39% of fetuses had both eyes closed compared to 2% in controls. higher dose ... | 1985 | 4035594 |
| [screening for congenital hypothyroidism]. | in the netherlands nation-wide screening for ch began in january 1981. the aim of the combined t4-tsh screening method is to detect all forms of ch, primary as well as secondary and tertiary. more than 99% of the newborns are screened. the rate of false-positives in premature infants was reduced in june 1982 by a change of the indications for follow-up. further study is performed on t4 values of premature infants. the information, given to the parents in case of recall, is not optimal yet. altho ... | 1985 | 4035661 |
| results of radical cystectomy for primary bladder cancer. retrospective study of more than 200 cases. | during a seven-year period 202 patients with primary bladder cancer had radical cystectomy with bilateral pelvic lymphadenectomy and urinary diversion. lymph node metastases were found in 28.7 per cent. no significant differences in overall survival owing to age were apparent. only extension and grade of histopathologic differentiation of the tumor proved to be an important prognostic factor. the five-year survival rates for pt1, pt2, pt3, and pt4 tumors were 76, 56, 19, and 0 per cent, respecti ... | 1985 | 4035840 |
| serum thyroglobulin (tg) stimulation with bovine tsh: a useful test for diagnosis of congenital goitrous hypothyroidism due to defective tg synthesis. | sixteen patients with congenital goitre were submitted to a bovine tsh stimulation test (btsh), and serum thyroid hormones (t3, t4), tsh and thyroglobulin (tg) were measured before and after btsh injection. in 9 patients with an organification defect basal levels of tg were normal (19.4 +/- 3.1 micrograms/l) rising after btsh to a mean level +/- sem of 37.3 +/- 4.1 micrograms/l. six patients with defective tg synthesis or release had a mean basal level of serum tg of 8.7 +/- 1.9 microgram/l (mea ... | 1985 | 4036506 |
| [determination of the free thyroxine concentration (ft4) in serum using the ft4 fraction and total thyroxine concentration]. | a new equilibrium assay for the determination of serum free thyroxine was evaluated in 514 patients. the assay comprises a two-vial-procedure to measure total thyroxine and free thyroxine fraction by use of monoclonal antibodies. free thyroxine concentrations are calculated from ft4-fraction and total thyroxine concentration readings. in euthyroidism the average free thyroxine fraction (%ft4) was 0.011%, in hyperthyroidism this fraction was elevated, in hypothyroidism it was below normal. in pat ... | 1985 | 4036525 |
| the bone marrow in aids. a histologic, hematologic, and microbiologic study. | during one year, 55 bone marrow biopsies from 49 patients with cdc-defined acquired immune deficiency syndrome (aids) were studied. eighty-three percent were normocellular or hypercellular; 17% were hypocellular. marrow plasma cells were increased in 83% of patients, most showing polyclonal hypergammaglobulinemia. forty percent of patients showed peripheral neutropenia, 29% thrombocytopenia, and 79% lymphopenia with markedly reduced t4+ lymphocytes. eighty-five percent of patients were anemic, w ... | 1985 | 4036875 |
| [retrospective study of the treatment of piriform sinus cancers. apropos of 97 cases]. | results of a retrospective analysis of case-reports of 97 patients treated for piriform sinus cancer showed a high frequency of large tumors and adenopathies providing an explanation for the very poor prognosis of these cancers. therapy of choice for t1-t2 tumors is still radiotherapy. however, recently obtained results and data from the literature demonstrate the increased benefits of partial surgery with monoblock curettage followed by radiotherapy in cases with an ulcerous tumor, a mobile lar ... | 1985 | 4037613 |
| autonomic dysreflexia due to medication: misadventure in the use of an isometheptene combination to treat migraine. | autonomic dysreflexia, a syndrome sometimes occurring in spinal cord injured (sci) individuals, may be life-threatening. it involves, in varying degrees, hypertension, diaphoresis, headache, bradycardia, anxiety, and flushing and is believed due to unrestricted sympathetic activity below the level of the lesion in individuals with injuries above t4-6. the most frequent causes of the syndrome are urinary infections, rectal impaction, bladder distention, and decubitus ulcers. to our knowledge, med ... | 1985 | 4038034 |
| annual and diurnal cycles in plasma testosterone and thyroxine in the male green sea turtle chelonia mydas. | male plasma testosterone (t) and thyroxine (t4) were monitored over several annual cycles in a captive breeding colony of green sea turtles, chelonia mydas. daily and annual water temperatures varied by only approximately 1 and 3 degrees, respectively. a pronounced season cycle in plasma t was evident in the population as a whole and in individual animals: plasma t was at a nadir (approximately 3 ng/ml) in september-november and then increased progressively to a peak (27-39 ng/ml) in april; leve ... | 1985 | 4039277 |
| [male infertility with chromosomal abnormalities. i. xyy syndrome]. | chromosomal abnormalities are found in a considerably high percentage of cases of male infertility, in particular azoospermia. we report a case of the xyy syndrome and review the literature. a 36-year-old man, a factory hand, presented with infertility. he was safely delivered at term as a fourth child when his father was 41 years old and his mother 38. he had no delinquent or criminal record. his height was 179 cm, weight 75 kg and distance of extended hands 184 cm. no gynecomastia was noticed. ... | 1985 | 4039524 |
| effect of chronic methadone administration on neuroendocrine function in young adult rats. | this study reports the endocrine effects of chronic methadone (meth) administration. two treatment regimens were tested: a constant (5 mg/kg/day, cd) or increasing dose (5 mg/kg twice daily, increasing 1 mg/kg/day, id). basal hormone levels and endocrine responses to opiate challenge were determined on days 5, 10 and 20 and after withdrawal. meth effects on hormone secretion varied with treatment duration, dose and hormone. tolerance to meth effects on corticosterone (cs), prolactin (prl), growt ... | 1985 | 4040169 |
| [lugol's solution and thyroid gland activity in cattle. determination of the total thyroxine in blood plasma as a method for evaluating thyroid gland activity]. | the aim of the present investigations was to examine if an intrauterine treatment with lugol's solution in cows influences the activity of the thyroid gland. the thyrotropin-stimulation test was used to evaluate the function of the thyroid gland. an injection of 10 i. u. thyreotropin induced within 3 hours an increase of the t4 blood concentrations which reached maximal values 9 hours after the treatment and thereafter decreased again. thyreotropin concentrations increasing from 5 to 30 i. u. le ... | 1985 | 4040285 |
| one year of ethanol feeding increases circulating thyroid hormones in the dog. | nine greyhound dogs were fed ethanol for 1 year to examine the effects of long-term ethanol feeding on circulating thyroid hormones. the dose of ethanol consumed per day was 2 gm/kg for the first month, 3 gm/kg for the second month, and 4 gm/kg for the rest of the study. plasma triiodothyronine (t3), thyroxine (t4), and reverse triiodothyronine (rt3) were measured by radioimmunoassay. plasma t3 and t4 concentrations increased significantly during the period of ethanol administration compared wit ... | 1985 | 4040544 |
| effects of thyroid and growth hormone deficiency, and food restriction on heart mass, with and without added stress (carboxyhemoglobinemia). | the roles of thyroid and growth hormone, and food restriction in maintenance of heart mass and in carbon monoxide-stimulated cardiac growth were examined. first, thyroidectomized and normal adult male rats inhaled up to 500 ppm co in air for 42 days. combined ventricular weights of thyroidectomized rats inhaling co and air were 12 and 23% smaller than predicted, respectively, while the combined ventricular weight of normal rats inhaling co was 29% larger than predicted. thyroidectomy increased t ... | 1985 | 4042003 |