Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin in the treatment of secondary hemophagocytic lymphohistiocytosis with classical hodgkin lymphoma: a case report and review of the literature. | hemophagocytic lymphohistiocytosis is becoming an increasingly recognized disorder in adults. classical hodgkin lymphoma is a relatively uncommon etiology of hemophagocytic lymphohistiocytosis and may complicate treatment options. rituximab, etoposide, methylprednisolone, high-dose cytarabine, and cisplatin are discussed here as a treatment regimen. | 2016 | 27998299 |
| acute flaccid myelitis in the united states, august-december 2014: results of nationwide surveillance. | during late summer/fall 2014, pediatric cases of acute flaccid myelitis (afm) occurred in the united states, coincident with a national outbreak of enterovirus d68 (ev-d68)-associated severe respiratory illness. | 2016 | 27318332 |
| genetic variation and dynamics of infections of equid herpesvirus 5 in individual horses. | equid herpesvirus 5 (ehv-5) is related to the human epstein-barr virus (human herpesvirus 4) and has frequently been observed in equine populations worldwide. ehv-5 was previously assumed to be low to non-pathogenic; however, studies have also related the virus to the severe lung disease equine multinodular pulmonary fibrosis (empf). genetic information of ehv-5 is scanty: the whole genome was recently described and only limited nucleotide sequences are available. in this study, samples were tak ... | 2016 | 26518010 |
| t-cell libraries allow simple parallel generation of multiple peptide-specific human t-cell clones. | isolation of peptide-specific t-cell clones is highly desirable for determining the role of t-cells in human disease, as well as for the development of therapies and diagnostics. however, generation of monoclonal t-cells with the required specificity is challenging and time-consuming. here we describe a library-based strategy for the simple parallel detection and isolation of multiple peptide-specific human t-cell clones from cd8(+) or cd4(+) polyclonal t-cell populations. t-cells were first amp ... | 2016 | 26826277 |
| targeting epstein-barr virus-transformed b lymphoblastoid cells using antibodies with t-cell receptor-like specificities. | epstein-barr virus (ebv) is an oncovirus associated with several human malignancies including posttransplant lymphoproliferative disease in immunosuppressed patients. we show here that anti-ebv t-cell receptor-like monoclonal antibodies (tcr-like mabs) e1, l1, and l2 bound to their respective hla-a*0201-restricted ebv peptides ebna1562-570, lmp1125-133, and lmp2a426-434 with high affinities and specificities. these mabs recognized endogenously presented targets on ebv b lymphoblastoid cell lines ... | 2016 | 27338099 |
| chimerically fused antigen rich of overlapped epitopes from latent membrane protein 2 (lmp2) of epstein-barr virus as a potential vaccine and diagnostic agent. | epstein-barr virus (ebv) is prevalent throughout the world and is associated with several malignant diseases in humans. latent membrane protein 2 (lmp2) of ebv plays a crucial role in the pathogenesis of ebv-associated tumors; therefore, lmp2 has been considered to be a potential immunodiagnostic and immunotherapeutic target. a multi-epitope-based antigen is a promising option for therapeutic vaccines and diagnoses of such malignancies. in this study, we systematically screened cytotoxic t lymph ... | 2016 | 25864917 |
| soluble expression and purification of the functional interleukin-30 protein in escherichia coli. | interleukin-30 (il-30), or il-27p28, is the α subunit of il-27 constructed by epstein-barr virus-induced gene 3 (ebi3) and il-27p28 binding via noncovalent bonds. il-30 can be independently secreted and function independently of il-27. recent studies demonstrated il-30 could concurrently antagonize t helper 1 (th1) and th17 responses and might have therapeutic implications for controlling autoimmune diseases. however, no reports have stated an efficient method to generate a relatively large quan ... | 2016 | 26176652 |
| human wharton's jelly-derived mesenchymal stromal cells engineered to secrete epstein-barr virus interleukin-10 show enhanced immunosuppressive properties. | mesenchymal stromal cells (mscs) modulate the immune response and represent a potential treatment for inflammatory and autoimmune diseases. we hypothesized that this feature could be potentiated by co-administering anti-inflammatory cytokines. in this article, we asked whether engineering of wharton jelly-derived human mscs (wj-hmscs) to express an anti-inflammatory cytokine increases cell immunomodulatory properties without altering their native features. | 2016 | 26794713 |
| heterophile antibody positive, acute cytomegaloviral infection in an immunocompetent pre-teen: an atypical presentation of an atypical infection. | mononucleosis and mononucleosis-like illnesses comprise a significant proportion of pediatric and adolescent infectious illnesses. by far, the most common cause of these illnesses is epstein-barr virus, which causes mononucleosis, and a distant second is cytomegalovirus, which is the most common cause of mononucleosis-like illnesses. this case provides an interesting juxtaposition of laboratory findings of an adolescent who was heterophile antibody positive but acute epstein-barr virus antigen-a ... | 2016 | 25270386 |
| [detection of the markers of herpesvirus infections in stomach diseases of inhabitants of the republic of mordovia]. | the study included 120 patients with pre-cancer conditions of the stomach and 30 patients with gastric cancer stage ii-iv. the elisa method in the blood serum was used to determine the markers of the infection caused by herpes simplex virus (hsv) types 1 and 2, cytomegalovirus (cmv), and epstein-barr virus (ebv). the majority of the patients exhibited high titers of markers of herpesvirus mixed infection. these data allow recommending the determination of igg antibodies to antigens of herpesviru ... | 2016 | 24006634 |
| herbal hepatotoxicity and who global introspection method. | herbal hepatotoxicity is a rare but highly disputed disease because numerous confounding variables may complicate accurate causality assessment. case evaluation is even more difficult when the who global introspection method (who method) is applied as diagnostic algorithm. this method lacks liver specificity, hepatotoxicity validation, and quantitative items, basic qualifications required for a sound evaluation of hepatotoxicity cases. consequently, there are no data available for reliability, s ... | 2016 | 23293189 |
| mosquito vectors and the spread of cancer: an overlooked connection? | mosquitoes (diptera: culicidae) represent a key threat for millions of humans and animals worldwide, vectoring important pathogens and parasites, including malaria, dengue, filariasis, and zika virus. besides mosquito-borne diseases, cancers figure among the leading causes of mortality worldwide. it is expected that annual cancer cases will rise from 14 million in 2012 to 22 million within the next two decades. notably, there are few contrasting evidences of the relationship between cancer and m ... | 2016 | 27053131 |
| cd123 redirected multiple virus-specific t cells for acute myeloid leukemia. | hematopoietic stem cell transplantation (hsct) has been increasingly used as a curative treatment for acute myeloid leukemia (aml). however, relapse rates after hsct in complete remission (cr) are reported between 30% and 70%. in addition, numerous studies suggested that secondary viral infection from a variety of viruses including epstein-barr virus (ebv), adenovirus (adv), and cytomegalovirus (cmv) are among the most common causes of death post-hsct. currently, chimeric antigen receptor (car)- ... | 2016 | 26740053 |
| monitoring of epstein-barr virus (ebv)/cytomegalovirus (cmv)/varicella-zoster virus (vzv) load in patients receiving tocilizumab for rheumatoid arthritis. | il-6 is involved in viral immunosurveillance. we studied the effect of tocilizumab (tcz) on the evolution in viral load (vl) for the epstein-barr virus (ebv), cytomegalovirus (cmv) and varicella-zoster virus (vzv) in patients with rheumatoid arthritis (ra). | 2016 | 26725744 |
| acute viral hepatitis presenting as cytomegalovirus, hepatitis e and epstein-barr virus igm antibody positive. | we report a case of acute cytomegalovirus (cmv) infection with positive hev and epstein-barr virus (ebv) serology. no patients have been reported positive for immunoglobulin (ig)m antibodies to all three viruses. this patient had progressively increasing titres of igm antibody for cmv, hev and ebv. only cmv dna was detectable before antiviral treatment. after antiviral treatment, the patient recovered completely. at day 180 the cmv igg test had converted to positive with cmv igm (+), ebv igm (-) ... | 2016 | 26376744 |
| viral exposures and ms outcome in a prospective cohort of children with acquired demyelination. | epstein-barr virus (ebv) infection is associated with increased multiple sclerosis (ms) risk. recently, cytomegalovirus (cmv) infection has been proposed as a protective factor against ms development. we determined ebv, herpes simplex virus, varicella-zoster virus and cmv seroprevalence in 247 prospectively followed children with acquired demyelinating syndromes (ads). remote ebv infection was more common in children with ms than those with monophasic ads while cmv infection was more common in c ... | 2016 | 26199356 |
| cytomegalovirus and other common enteric viruses are not commonly associated with nec. | changes in gut microbiota may contribute to nec, but most studies focus on bacteria. case reports suggest a link between cytomegalovirus (cmv) or other enteric viruses and nec, but there are few case series systematically looking at common potential viral causes. we aimed to assess the presence of candidate viruses in blood or stool of a case series of infants with nec managed in one surgical centre. | 2016 | 26148222 |
| cytomegalovirus- and epstein-barr virus-induced t-cell expansions in young children do not impair naive t-cell populations or vaccination responses: the generation r study. | cytomegalovirus (cmv) and epstein-barr virus (ebv) induce effector memory t-cell expansions, which are variable and potentially depend on the age at primary exposure and coinfections. we evaluated the t-cell compartment and herpesvirus infections in 6-year-old children. | 2016 | 26142434 |
| the influence of primary cytomegalovirus or epstein-barr virus infection on the course of idiopathic thrombocytopenic purpura. | idiopathic thrombocytopenic purpura (itp) in children is usually triggered by a viral infections such as cytomegalovirus (cmv) or epstein-barr virus (ebv) infection. the aim of this study was to assess the frequency of cmv and ebv infections in children with first relapse of itp, and the influence of these infections on the course and response to treatment of itp. sixty patients (30 boys and 30 girls) with itp were enrolled into the study. we found that the age at the onset of itp was from 1 mon ... | 2016 | 26269027 |
| associations between ebv and cmv seropositivity, early exposures, and gut microbiota in a prospective birth cohort: a 10-year follow-up. | early-life infections with persistent epstein-barr virus (ebv) and cytomegalovirus (cmv) are delayed in affluent countries, probably due to alterations in early environmental exposures, such as maternal age, siblings, and day-care attendance. we have previously reported that the timing of ebv and cmv contraction is related both to allergic sensitization and changes in functional competence of immune cells, while the presence/absence of lactobacilli [lactobacillus (l.) casei, l. paracasei, and l. ... | 2016 | 27630978 |
| shedding of hsv-1, hsv-2, cmv, and ebv in the saliva of hematopoietic stem cell transplant recipients at fundación homi - hospital de la misericordia, bogotá, d.c. | hematopoietic stem cell transplantation in pediatric patients is an alternative treatment for different diseases. the conditioning regimen for transplant predisposes recipients to the development of infections. viral infections by herpes simplex virus 1 (hsv-1), herpes simplex virus 2 (hsv-2), human cytomegalovirus (cmv), and epstein-barr virus (ebv), are the most common, and the leading cause of morbidity and mortality among these patients. these viruses lie dormant in various cell types and th ... | 2016 | 27622810 |
| asymptomatic cmv replication during early human immunodeficiency virus (hiv) infection is associated with lower cd4/cd8 ratio during hiv treatment. | a low cd4/cd8 ratio in human immunodeficiency virus (hiv)-infected individuals is associated with inflammation and higher risk of non-aids morbidity and mortality. in this study, we investigated the effect of subclinical cytomegalovirus (cmv) and epstein-barr virus (ebv) replication on cd4(+) and cd8(+) t-cell dynamics when antiretroviral therapy (art) is started during early infection. | 2016 | 27601222 |
| [clinical and genetic analysis for activated pi3k-δ syndrome by pik3cd gene mutation]. | to analyze clinical and genetic features of activated pi3k-δ syndrome (apds), a new form of immunodeficiency disease caused by pik3cd gene mutation. | 2016 | 27596086 |
| fulminant anaplastic large cell lymphoma (alcl) concomitant with primary cytomegalovirus (cmv) infection, and human herpes virus 8 (hhv-8) infection together with epstein-barr-virus (ebv) reactivation in a patient with asymptomatic hiv-infection. | most malignant lymphomas in hiv-patients are caused by reactivation of ebv-infection. some lymphomas have a very rapid fulminant course. hhv-8 has also been reported to be a cause of lymphoma. the role of cmv in the development of lymphoma is not clear, though both cmv and hhv-8 have been reported in tissues adjacent to the tumour in burkitt lymphoma patients. here we present a patient with asymptomatic hiv infection, that contracted a primary cytomegalovirus (cmv) infection and human herpes vir ... | 2016 | 27551290 |
| compartmentalization of total and virus-specific tissue-resident memory cd8+ t cells in human lymphoid organs. | disruption of t cell memory during severe immune suppression results in reactivation of chronic viral infections, such as epstein barr virus (ebv) and cytomegalovirus (cmv). how different subsets of memory t cells contribute to the protective immunity against these viruses remains poorly defined. in this study we examined the compartmentalization of virus-specific, tissue resident memory cd8+ t cells in human lymphoid organs. this revealed two distinct populations of memory cd8+ t cells, that we ... | 2016 | 27540722 |
| the role of human papilloma virus and herpes viruses in the etiology of nasal polyposis. | the aim of this study was to investigate the etiological role of human papilloma virus (hpv), herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), and human herpes virus-6 (hhv-6) and -7 (hhv-7) in the occurrence of nasal polyposis. | 2016 | 27511490 |
| cervical lymphadenopathies in children: a prospective clinical cohort study. | cervical lymphadenopathy (lap) is a common sign and may raise fears about serious illnesses. the aim of our study was to evaluate the patients with cervical laps in a general pediatrics clinic setting, and to evaluate follow-up results for potential causes and risk factors for malignancies. | 2016 | 26857321 |
| replication of human herpesviruses is associated with higher hiv dna levels during antiretroviral therapy started at early phases of hiv infection. | asymptomatic replication of human herpesviruses (hhv) is frequent in hiv-infected men and is associated with increased t-cell activation and hiv disease progression. we hypothesized that the presence of replication of cytomegalovirus (cmv) and epstein-barr virus (ebv) (the most frequently detected hhv) might influence hiv dna decay during antiretroviral therapy (art). we investigated 607 peripheral blood mononuclear cell (pbmc) samples from 107 cmv-seropositive, hiv-infected men who have sex wit ... | 2016 | 26842469 |
| viral infections of the central nervous system in elderly patients: a retrospective study. | very few data exist on viral meningitis and encephalitis in elderly patients (>65 years old). | 2016 | 26820759 |
| absence of human herpesvirus 6b detection in association with illness in children undergoing cancer chemotherapy. | the lymphotropic herpesviruses, cytomegalovirus (cmv), epstein-barr virus (ebv), and human herpesvirus 6b (hhv-6b) can reactivate and cause disease in organ transplant recipients; the contributions of hhv-6a and hhv-7 to disease are less certain. less is known about their pathogenic roles in children undergoing treatment for malignancies. children with newly diagnosed cancer were followed for 24 months. clinical information and blood samples were collected during routine visits and during acute ... | 2016 | 26815906 |
| exposure to perinatal infections and bipolar disorder: a systematic review. | bipolar disorder (bd) is a debilitating psychiatric disorder and a growing global public health issue. notwithstanding bd has been conceptualized as a neuroprogressive illness, there are some evidences to suggest a role for neurodevelopmental pathways in the patho-etiology of this disorder. evidences on the associations between perinatal infections and risk for bipolar disorder have been inconsistent across studies. here, we performed a systematic review of observational studies on the relations ... | 2016 | 26812921 |
| rapid reconstitution of cd4 t cells and nk cells protects against cmv-reactivation after allogeneic stem cell transplantation. | epstein-barr virus and cytomegalovirus reactivations frequently occur after allogeneic stem cell transplantation (sct). | 2016 | 27484705 |
| human herpesvirus multiplex ddpcr detection in brain tissue from low- and high-grade astrocytoma cases and controls. | glioblastoma (gbm) is a fatal cns malignancy, representing 50 % of all gliomas with approximately 12-18 months survival time after initial diagnosis. recently, the human herpesvirus cytomegalovirus (cmv) has been suggested to have an oncogenic role, yet this association remains controversial. in addition, human herpesvirus 6 (hhv-6) and epstein-barr virus (ebv) have also been associated with low-grade gliomas, but few studies have examined hhv-6 and ebv in glioblastomas. droplet digital pcr (ddp ... | 2016 | 27462365 |
| cytomegalovirus and epstein-barr virus reactivation in the intensive care unit. | the purpose of this work was to evaluate the reactivation of cytomegalovirus (cmv) and epstein-barr virus (ebv) in immunocompetent patients in the intensive care unit (icu) and to identify risk factors associated with reactivation. | 2016 | 27435067 |
| viral colonization in exhaled breath condensate of lung cancer patients: possible role of ebv and cmv. | today, an increasing interest is being addressed to the viral etiology of lung tumors. as a consequence, research efforts are currently being directed to the identification of the new viruses involved in lung carcinogenesis toward which the screening programs could be directed. | 2016 | 27421948 |
| determinants of ethnic differences in cytomegalovirus, epstein-barr virus, and herpes simplex virus type 1 seroprevalence in childhood. | to identify whether there are ethnic differences in cytomegalovirus (cmv), epstein-barr virus (ebv), and herpes simplex virus type 1 (hsv-1) seroprevalence rates in children at 6 years of age, and when present, to evaluate how these differences can be explained by sociodemographic and environmental factors. | 2016 | 26707579 |
| evaluation of a standardised real-time pcr based dna-detection method (realstar®) in whole blood for the diagnosis of primary human cytomegalovirus (cmv) infections in immunocompetent patients. | cytomegalovirus (cmv) dna detection in blood could, as a supplementary test to serology, improve the accuracy and speed of diagnosis of an acute cmv infection. in this study we evaluated the performance of a commercially available and standardised cmv pcr assay in whole blood for the diagnosis of a primary infection in immunocompetent adults. moreover, the kinetics of viral dna was evaluated in order to provide a time frame in which viral dna could be detected during an acute primary infection. ... | 2016 | 26661089 |
| decrease in seroprevalence for herpesviruses among pregnant women in finland: cross-sectional study of three time points 1992, 2002 and 2012. | maternal herpesvirus infections during pregnancy may cause fetal and neonatal infections. we investigated the seroprevalence of five herpesviruses: cytomegalovirus (cmv), herpes simplex virus (hsv) 1 and 2, varicella zoster virus (vzv) and epstein-barr virus (ebv) in randomly selected samples from pregnant finnish women from the years 1992, 2002 and 2012. over 20 years, the seroprevalences decreased significantly for cmv from 84.5% to 71.5% (p = 0.007) and hsv-1 from 69.5% to 45% (p < 0.001). th ... | 2016 | 26654892 |
| epstein-barr and cytomegalovirus dna salivary shedding correlate with long-term plasma hiv rna detection in hiv-infected men who have sex with men. | the aim of the study was to evaluate cytomegalovirus (cmv) and epstein-barr virus (ebv) dna salivary shedding in hiv-positive men who have sex with men (msm) and to determine whether viro-immunological parameters and long-term (24 months) plasma hiv rna (phiv) detection may predict herpesviruses replication. a total of 193 hiv-positive msm were consecutively recruited (mean cd4+ cell count 607 cells/mm(3) and mean nadir value 333 cells/mm(3) ); phiv was analyzed for 24 months prior to saliva sam ... | 2016 | 26636290 |
| virus-specific cd8(+) t cells cross-reactive to donor-alloantigen are transiently present in the circulation of kidney transplant recipients infected with cmv and/or ebv. | t cells play a dual role in transplantation: they mediate transplant rejection and are crucial for virus control. memory t cells generated in response to pathogens can cross-react to alloantigen, a phenomenon called heterologous immunity. virus-specific cd8(+) t cells cross-reacting to donor-alloantigen might affect alloimmune responses and hamper tolerance induction following transplantation. here, we longitudinally studied these cross-reactive cells in peripheral blood of 25 kidney transplant ... | 2016 | 26603974 |
| time-series analysis comparing the prevalence of antibodies against nine viral species found in umbilical cord blood in japan. | in this study, we investigated the prevalence of antibodies against 9 viral species found in umbilical cord blood from 561 neonates in 2013. serum igg antibodies against the following viruses were measured: herpes simplex virus (hsv), varicella-zoster virus (vzv), epstein-barr virus (ebv), cytomegalovirus (cmv), human herpesvirus 6 (hhv-6), measles virus (mv), rubella virus (rv), mumps virus (muv), and human parvovirus b19 (hpv b19). a survey questionnaire regarding past medical history and mate ... | 2016 | 26567842 |
| simultaneous quantification of the 8 human herpesviruses in allogeneic hematopoietic stem cell transplantation. | human herpesviruses may cause severe complications after allogeneic hematopoietic stem cell transplantation (hsct). however, the impact of some of these infections on transplant outcomes is still unclear. a prospective survey on the incidence and clinical features of herpesviruses infections after hsct has not yet been conducted in brazilian patients, and the impact of these infections on hsct outcome remains unclear. | 2016 | 26555946 |
| a fatal case of dress induced by strontium ranelate associated with hhv-7 reactivation. | we report the first case of drug rash with eosinophilia and systemic symptoms (dress) following strontium ranelate (sr) treatment associated with systemic human hhv-7 reactivation. dress syndrome is a severe adverse drug-induced reaction presenting as a diffuse maculopapular skin rash with fever, hematological abnormalities (leukocytosis, eosinophilia, and/or atypical lymphocytosis), and multiorgan involvement. in our patient, diagnosis of dress was confirmed by the presence of six of the seven ... | 2016 | 26519419 |
| effects of lactobacillus casei shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. | to assess evidence of health and immune benefit by consumption of a lactobacillus casei shirota probiotic in highly physically active people. | 2016 | 27294502 |
| clinical and laboratory differences between epstein-barr and cytomegalovirus infectious mononucleosis in children. | infective mononucleosis is most commonly caused by epstein-barr virus (ebv), and in smaller percentage by cytomegalovirus (cmv). | 2016 | 27276859 |
| detection of epstein-barr virus and cytomegalovirus in gastric cancers in kerman, iran. | gastric cancer (gc) is a multifactorial disease with different factors having roles in its genesis. helicobacter pylori and epstein-barr virus (ebv) are known infectious agents that could contribute. in addition, there is evidence of a relationship with cytomegalovirus (cmv). since data on cmv prevalence in gastric cancer are limited, we here evaluated the frequency of ebv and cmv in iranian patients. ninety paraffin blocks of gc tissues from patients in kerman were evaluated for the presence of ... | 2016 | 27268608 |
| risk factors and utility of a risk-based algorithm for monitoring cytomegalovirus, epstein-barr virus, and adenovirus infections in pediatric recipients after allogeneic hematopoietic cell transplantation. | infectious complications, particularly viral infections, remain a significant cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allohct). only a handful of studies in children have analyzed the risks for and impact of viremia on allohct-related outcomes. we conducted a retrospective study of 140 pediatric patients undergoing allohct to investigate the incidence of and risk factors for cytomegalovirus (cmv), adenovirus (adv), and epstein-barr virus (ebv) viremi ... | 2016 | 27252110 |
| association of viral infections with risk of human lymphomas, egypt. | the aim of this study was to determine and evaluate the association of different viral infections, with hepatitis b and c viruses, epstein-barr virus, cytomegalovirus and human herpes virus-8 (hbv, hcv, ebv, cmv, hhv-8) with the risk of lymphomas (hodgkin and non-hodgkin) among egyptian patients, and correlate with the histopathological staging and typing as well as the prevalence of combined infections. | 2016 | 27221841 |
| a single exercise bout enhances the manufacture of viral-specific t-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy. | cytomegalovirus (cmv) and epstein-barr virus (ebv) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (hsct). the adoptive transfer of donor-derived viral-specific cytotoxic t-cells (vsts) is an effective treatment for controlling cmv and ebv infections after hsct; however, new practical methods are required to augment the ex vivo manufacture of multi-vsts from healthy donors. this study investigated the effects of a single exercis ... | 2016 | 27181409 |
| the correlation between the virus- and brain antigen-specific b cell response in the blood of patients with multiple sclerosis. | there is a largely divergent body of literature regarding the relationship between epstein-barr virus (ebv) infection and brain inflammation in multiple sclerosis (ms). here, we tested ms patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the ebv- and brain-specific b cell response in the blood by enzyme-linked immunospot (elispot) and enzyme-linked immunosorbent assay (elisa). cytomegalovirus (cmv) was used as a con ... | 2016 | 27120609 |
| [adrenalitis]. | inflammation of the adrenal glands is caused by autoimmunopathies or infections and can induce adrenal insufficiency. autoimmune lymphocytic adrenalitis is often combined with other autoimmune diseases and the most frequent cause of addison's disease; however, it only becomes clinically apparent when more than 90 % of the adrenal cortex has been destroyed. histological features are characterized by lymphoplasmacytic inflammation leading to an increased destruction of adrenocortical tissue but le ... | 2016 | 27099224 |
| recombinase activating gene 1 deficiencies without omenn syndrome may also present with eosinophilia and bone marrow fibrosis. | severe combined immunodeficiency (scid) syndromes are a heterogenous group of diseases characterized by impairment in both cellular and humoral immunity with a range of genetic disorders. complete recombinase activating gene (rag) deficiency is associated with classical t(-)b(-)nk(+) scid which is the most common phenotype of turkish scid patients. there is a broad spectrum of hypomorfic rag mutations including omenn syndrome, leaky or atypical scid with expansion of γδ t cells, autoimmunity and ... | 2016 | 27081423 |
| gianotti-crosti syndrome as presenting sign of cytomegalovirus infection: a case report and a critical appraisal of its possible cytomegalovirus etiology. | gianotti-crosti syndrome (gcs) is a self-limiting exanthem of acute onset with a characteristic acral distribution, usually occurring in children. it is characterized by symmetric pink to red-brown papular or papulovesicular lesions that are a few millimetres in diameter, distributed on the face, buttocks and limbs. it may be accompanied by low-grade fever, hepato-splenomegaly and lymphadenopathy. gcs is considered a unique cutaneous response to viral infection, mostly associated with hepatitis ... | 2016 | 27017141 |
| [clinical risks analysis of ebv infection in patients with allogeneic hematopoietic stem cell transplantation]. | to analyze the prevalence of epstein barr virus (ebv) infection in patients following allogeneic hematopoietic stem cell transplantation (allo-hsct). | 2016 | 27014984 |
| demonstration of herpes simplex virus, cytomegalovirus, and epstein-barr virus in colorectal cancer. | the present study sought to investigate molecular evidence for association between the presence of herpes simplex virus (hsv), cytomegalovirus (cmv), and epstein-barr virus (ebv) in crc and colorectal polyp by using the pcr method in iran. | 2016 | 26975327 |
| the natural history of human polyomaviruses and herpesviruses in early life--the rhea birth cohort in greece. | sparse data exist on the patterns and determinants of acquisition of polyomaviruses and herpesviruses in childhood. we measured immunoglobulin g seroreactivity against 10 polyomaviruses (bkpyv, jcpyv, kipyv, wupyv, mcpyv, hpyv6, hpyv7, tspyv, hpyv9, hpyv10) and 5 herpesviruses (epstein barr virus (ebv), cytomegalovirus (cmv), herpes simplex virus types 1 and 2, human herpesvirus 8) using multiplex serology on blood samples collected at birth (cord blood, n = 626) and at follow-up at 3 years (n = ... | 2016 | 26968942 |
| prospective characterization of the risk factors for transmission and symptoms of primary human herpesvirus infections among ugandan infants. | human herpesvirus (hhv) infections are common during infancy. primary infections are frequently asymptomatic and best studied prospectively by using direct viral detection. | 2016 | 26917575 |
| herpesvirus infections and transglutaminase type 2 antibody positivity in childhood: the generation r study. | persistent viral infections have been implicated in the etiology of autoimmune diseases in adulthood, but it is not known whether herpesviruses are associated with the development of celiac disease autoimmunity in childhood. we assessed whether herpesvirus infections are associated with transglutaminase type 2 antibody (tg2a) concentrations in children at 6 years of age. | 2016 | 26881413 |
| cervical viral infections among asymptomatic bulgarian women. | although sexually transmitted viral infections are significant and increasing public health concern, little is known about their prevalence among bulgarian women. the aim of this study was to investigate cervical viral infections in asymptomatic women. | 2016 | 27760284 |
| role of mtor inhibitors for the control of viral infection in solid organ transplant recipients. | appropriate post-transplant immunosuppressive regimens that avoid acute rejection, while reducing risk of viral reactivation, have been sought, but remain a chimera. recent evidence suggesting potential regulatory and antiviral effects of mammalian target of rapamycin inhibitors (mtori) is of great interest. although the concept of an immunosuppressive drug with antiviral properties is not new, little effort has been made to put the evidence together to assess the management of immunosuppressive ... | 2016 | 27600985 |
| pretransplant prophylactic rituximab to prevent epstein-barr virus (ebv) viremia in ebv-seronegative kidney transplant recipients from ebv-seropositive donors: results of a pilot study. | because of the strikingly increased risk of post-transplant lymphoproliferative disorder (ptld) in epstein-barr virus (ebv)-seronegative kidney transplant recipients (ktrs) from ebv-seropositive donors-ebv(d(+) r(-) ), special strategies need to be defined to prevent ebv transmission and ebv viremia. | 2016 | 27632022 |
| prevalence of human papillomavirus, epstein-barr virus, and cytomegalovirus in fine needle aspirates from lung carcinoma: a case-control study with review of literature. | oncogenic viruses have recently been allied with lung carcinoma, however, the causal association has not been established till date. the study was conducted to determine the prevalence of high-risk human papillomavirus (hpv; subtypes 16, 18, 31, 33 and 45), epstein-barr virus (ebv) and cytomegalovirus (cmv) in lung carcinoma using polymerase chain reaction (pcr) on fine needle aspirates. | 2016 | 27774746 |
| longitudinal viral dynamics in semen during early hiv infection. | multiple viruses co-infect the male genital tract, influencing each other's replication and perhaps affecting hiv pathogenesis and disease progression. | 2016 | 27927863 |
| viral serological and molecular data on possible involvement of herpes viruses in periodontal disease. | recent studies have suggested that latent herpes virus infections can be associated with chronic periodontal sites that exhibit a predisposition to disease progression. the aim of this study was to identify the possible relationship between infections with cmv and ebv and the severity of periodontal disease. | 2016 | 27916250 |
| immune recovery and the risk of cmv/ ebv reactivation in children post allogeneic haematopoietic stem cell transplantation. | immune reconstitution was studied prospectively in 86 children who underwent allogeneic haematopoietic stem cell transplantation (hsct). we analysed the risk of cytomegalovirus (cmv) and epstein-barr virus (ebv) reactivation in correlation with the kinetics of immune recovery and in relation to other potential risk factors that may influence the reactivation of these viruses including: diagnosis, type of hsct, source of stem cells, type of conditioning, or the occurrence of graft-versus-host dis ... | 2016 | 27833447 |
| active cmv and ebv infections in renal transplant recipients with unexplained fever and elevated serum creatinine. | proper identification of active cytomegalovirus (cmv) and epstein-barr virus (ebv) infections are helpful for monitoring antiviral treatment in transplant recipients. qualitative and quantitative cmv, ebv dna pcr techniques in the context of serological tests are performed for early detection and differentiation of active and latent cmv and ebv infections in renal transplantation. basically, 129 renal transplanted recipients monitored carefully and hospitalized for unexplained elevated creatinin ... | 2016 | 27484706 |
| common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the rhea birth cohort in crete, greece. | viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. we aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. | 2016 | 27334233 |
| [molecular tests in diagnosis of cytomegalovirus (cmv), human herpesvirus 6 (hhv-6) and epstein-barr virus (ebv) using real-time pcr in hiv positive and hiv-negative pregnant women in ouagadougou, burkina faso]. | herpesvirus ebv, cmv and hhv-6 are viruses that evolve based on pandemic modeling and are responsible for congenital infections causing severe sequelae in infants. this study aims to determine the prevalence of cmv, ebv and hhv-6 among hiv (+) and hiv (-) pregnant women in ouagadougou. | 2016 | 27800078 |
| evaluation of ebv transformation of human memory b-cells isolated by facs and macs techniques. | several studies have been performed to develop effective neutralizing monoclonal antibodies. the epstein-barr virus (ebv) can efficiently immortalize b-cells to establish lymphoblastoid cell lines (lcl) and so it has been used extensively for transformation of b-cells to produce and secrete immunoglobulin. the present study addressed the effect of tlr7/8 agonist (r848), feeder cells layer and fluorescence-activated cell sorting (facs) and magnetic-activated cell sorting (macs) cell separation met ... | 2016 | 27043044 |
| serum level of c-reactive protein is not a parameter to determine the difference between viral and atypical bacterial infections. | c-reactive protein (crp) is an acute-phase reactant that increases in the circulation in response to a variety of inflammatory stimuli. elevated levels in serum during several infectious diseases have been reported. in this study, a highly sensitive crp enzyme immunoassay was used to evaluate serum crp values in patients with viral and atypical bacterial infections. patients (n = 139) with different viral or atypical bacterial infections (systemic or respiratory) and healthy controls (n = 40) we ... | 2016 | 26241406 |
| relationship among viremia/viral infection, alloimmunity, and nutritional parameters in the first year after pediatric kidney transplantation. | the immune development in pediatric transplantation (impact) study was conducted to evaluate relationships among alloimmunity, protective immunity, immune development, physical parameters, and clinical outcome in children undergoing kidney transplantation. we prospectively evaluated biopsy-proven acute rejection (bpar), de novo donor-specific antibody (dndsa) formation, viremia, viral infection, t cell immunophenotyping, and body mass index (bmi)/weight z scores in the first year posttransplanta ... | 2016 | 27989013 |
| molecular diagnostic of cytomegalovirus, epstein barr virus and herpes virus 6 infections among blood donors by multiplex real-time pcr in ouagadougou, burkina faso. | in most developing countries, cytomegalovirus (cmv), epstein barr virus (ebv) and herpes virus 6 (hhv-6) are not diagnosed in blood donors. the aim of this study is to determine the prevalence of these viruses in blood donors from the city of ouagadougou, burkina faso. | 2016 | 28154653 |
| etiological characteristics of chlamydia trachoma conjunctivitis of primary boarding school students in the qinghai tibetan area. | the aim of this study was to investigate the etiological characteristics of chlamydia trachomatis conjunctivitis among resident students at primary schools in the qinghai tibetan area in order to understand the distribution of c. trachomatis and other pathogenic microorganisms, to detect the isolation rate of infectious pathogens, and to provide an evidence for further targeted efforts in the prevent of sporadic trachoma efforts. from two primary schools in qinghai province, ocular samples from ... | 2016 | 27225259 |
| peptide based viral detection systems for effective diagnosis of common viral infections in india. | accurate and swift detection of viruses causing diseases in humans represent continuous challenges to diagnostic and epidemiological research. efficient and rapid diagnosis is also crucial for effective implication of diseases management strategies. multitude approaches attempted to identify individual viruses, includes serological assays and molecular methods. detection assays based on peptides have become increasingly substantial and indispensable for its advantages over conventional methods. ... | 2016 | 27455967 |
| investigating potential exogenous tumor initiating and promoting factors for cutaneous t-cell lymphomas (ctcl), a rare skin malignancy. | most skin malignancies are caused by external and often preventable environmental agents. multiple reports demonstrated that cutaneous t-cell lymphomas (ctcl) can occur in married couples and cluster in families. furthermore, recent studies document geographic clustering of this malignancy in texas as well as in other areas of the united states. multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide di ... | 2016 | 27622024 |
| infection is the major trigger of hemophagocytic syndrome in adult patients treated with biological therapies. | hemophagocytic syndromes (hemophagocytic lymphohistiocytosis, hlh) are characterized by a wide range of etiologies, symptoms, and outcomes, but have a common etiopathogenic pathway leading to organ damage: an excessive inflammatory response. biological therapies have been proposed as a therapeutic option for refractory hlh, but have also been related to the development of hlh in severe immunosuppressed patients. | 2016 | 26277577 |
| [infectious diseases after lung transplantation]. | lung transplantation is getting to be a common treatment for the end-stage respiratory failure. therefore we might encounter the various issues associated with infection under immunosuppression. at 1st, virus infections occur by cytomegalovirus, epstein-barr virus, hepatitis b and c virus and john cunningham virus. the 2nd, bacterial infections exacerbate graft condition by methicillin-resistant staphylococcus aureus, pseudomonas, burkholderia cepacia and coagulase negative staphylococci. the 3r ... | 2016 | 27713192 |
| pediatric miller fisher syndrome complicating an epstein-barr virus infection. | miller fisher syndrome, a variant of guillain-barré syndrome, is an acute inflammatory demyelinating polyradiculoneuropathy that may occur weeks after a bacterial or viral infection. campylobacter jejuni and haemophilus influenzae are frequently reported etiological agents. | 2016 | 27460528 |
| infectious agents associated with head and neck carcinomas. | in addition to traditional risk factors such as smoking habits and alcohol consumption, certain microbes also play an important role in the generation of head and neck carcinomas. infection with high-risk human papillomavirus types is strongly associated with the development of oropharyngeal carcinoma, and epstein-barr virus appears to be indispensable for the development of non-keratinizing squamous cell carcinoma of the nasopharynx. other viruses including torque teno virus and hepatitis c vir ... | 2016 | 26563307 |
| the use of brincidofovir for the treatment of mixed dsdna viral infection. | double-stranded dna (dsdna) viral infections constitute a major complication following solid organ and stem cell transplantation. few therapeutic options are currently available for the treatment of such infections in highly immunocompromised hosts. brincidofovir is an oral investigational drug with broad antiviral activity against dsdna viruses in vitro, but clinical experience is limited. here we report a young female who developed a mixed infection with adenovirus, cytomegalovirus, epstein-ba ... | 2016 | 27513204 |
| evaluation of a transcription mediated amplification assay for detection of herpes simplex virus types 1 and 2 mrna in clinical specimens. | herpes simplex viruses (hsv) are double-stranded dna human herpesviruses (hhvs) that have the capacity to cause significant morbidity and mortality in humans. like hhv5 (cytomegalovirus) and hhv8 (kaposi's sarcoma virus), hsv type 1 (hsv-1), and hsv type 2 (hsv-2) (hhv1, hhv2) selectively package certain viral messenger rnas inside mature virions, as well as expressing those mrnas in infected cells. | 2016 | 27175478 |
| herpesviral-bacterial co-infection in mandibular third molar pericoronitis. | the aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis. | 2016 | 27620215 |
| direct versus sequential immunoglobulin switch in allergy and antiviral responses. | allergy is characterized by ige production to innocuous antigens. the question whether the switch to ige synthesis occurs via direct or sequential pathways is still unresolved. the aim of this work was to analyze the distribution of immunoglobulins (ig) to house dust mite d. farinae and a. alternata fungus in allergic children with primarily established diagnosis and compare it to epstein-barr antiviral (ebv) response in the same patients. in allergy patients the only significant difference was ... | 2016 | 27471213 |
| nk cell influence on the outcome of primary epstein-barr virus infection. | the herpesvirus epstein-barr virus (ebv) was discovered as the first human candidate tumor virus in burkitt's lymphoma more than 50 years ago. despite its strong growth transforming capacity, more than 90% of the human adult population carries this virus asymptomatically under near perfect immune control. the mode of primary ebv infection is in part responsible for ebv-associated diseases, including hodgkin's lymphoma. it is, therefore, important to understand which circumstances lead to symptom ... | 2016 | 27621731 |
| mapping an epitope in ebna-1 that is recognized by monoclonal antibodies to ebna-1 that cross-react with dsdna. | the epstein barr virus (ebv) has been associated with the autoimmune disease, systemic lupus erythematosus (sle). ebv nuclear antigen-i (ebna-1) is the major nuclear protein of ebv. we previously generated an igg monoclonal antibody (mab) to ebna-1, 3d4, and demonstrated that it cross-reacts with double stranded dna (dsdna) and binds the 148 amino acid viral binding site (vbs) in the carboxyl region of ebna-1. the aim of the present study was to characterize another antibody to ebna-1 that cross ... | 2016 | 27621818 |
| the differentiation and protective function of cytolytic cd4 t cells in influenza infection. | cd4 t cells that recognize peptide antigen in the context of class ii mhc can differentiate into various subsets that are characterized by their helper functions. however, increasing evidence indicates that cd4 cells with direct cytolytic activity (cd4 ctl) play a role in chronic as well as acute infections, such as influenza a virus (iav) infection. in the last couple of decades, techniques to measure the frequency and activity of these cytolytic cells has demonstrated their abundance in infect ... | 2016 | 27014272 |
| cerebrospinal fluid in a small cohort of patients with multiple sclerosis was generally free of microbial dna. | multiple sclerosis (ms) is a common cause of non-traumatic neurologic disability with high incidence in many developed countries. although the etiology of the disease remains elusive, it is thought to entail genetic and environmental causes, and microbial pathogens have also been envisioned as contributors to the phenotype. we conducted a metagenomic survey in cerebrospinal fluid (csf) from 28 ms patients and 15 patients suffering other type of neurological conditions. we detected bacterial read ... | 2016 | 28111617 |
| unusual presentation of gianotti-crosti syndrome due to epstein-barr virus infection. | gianotti-crosti syndrome (gcs) is viral exanthema of childhood. it typically presents with a symmetric erythematous papular and papulovesicular eruption. it has been classically associated with hepatitis b virus, as well as rarely with epstein-barr virus (ebv). we report a case of gcs related to ebv infection without the classical systemic symptoms in a five-year-old male patient. | 2016 | 28050291 |
| is there any association between sarcoidosis and infectious agents?: a systematic review and meta-analysis. | during the last few years, investigators have debated the role that infectious agents may have in sarcoidosis pathogenesis. with the emergence of new molecular biology techniques, several studies have been conducted; therefore, we performed a meta-analysis in order to better explain this possible association. | 2016 | 27894280 |
| putative periodontopathic bacteria and herpesviruses in pregnant women: a case-control study. | little is known about herpesvirus and putative periodontopathic bacteria in maternal chronic periodontitis. the present case-control study aimed to explore the potential relationship between putative periodontopathic bacteria and herpesviruses in maternal chronic periodontitis.saliva samples were collected from 36 pregnant women with chronic periodontitis (cases) and 36 pregnant women with healthy periodontal status (controls). six putative periodontopathic bacteria (porphyromonas gingivalis [pg ... | 2016 | 27301874 |
| aqueous humor polymerase chain reaction in uveitis - utility and safety. | to study the value and safety of aqueous humor polymerase chain reaction (pcr) analysis for herpes simplex, varicella zoster, cytomegalovirus, epstein-barr virus and toxoplasma gondii in patients with uveitis. | 2016 | 27793120 |
| concordance of immune checkpoints within tumor immune contexture and their prognostic significance in gastric cancer. | checkpoint blockade therapy has emerged as a novel approach for cancer immunotherapy in several malignancies. however, patient prognosis and disease progression relevant to immune checkpoints in gastric tumor microenvironment are not defined. this study aims to investigate the expression and prognostic significance of immune checkpoints within gastric cancer. in the study, a cohort of 398 cancer tissues from stage i to iv gastric cancer patients were assessed for programmed cell death 1 ligand 1 ... | 2016 | 28949446 |
| intravenous immunoglobulin for pediatric neuropsychiatric lupus triggered by epstein-barr virus cerebral infection. | 2016 | 28457083 | |
| "the girl who grew horns": temporal swelling as an atypical presenting symptom of epstein-barr virus infection. | 2016 | 28457082 | |
| bilateral chorioretinal scars in a child - case report. | the eye manifestations of intrauterine infections are multiple, but chorioretinal scars and/or active chorioretinitis are the most frequently reported. when associated with other systemic manifestations of the infection, the diagnosis becomes more obvious, but when eye involvement is the only abnormality, etiology often remains uncertain. we are presenting the case of an 8-year-old female patient whose fundus lesions revealed an unusual choroidoretinopathy, associated with cataract in one eye. h ... | 2016 | 28461838 |
| epidemiological surveillance of herpes viral encephalitis in cordoba, colombia. | objective to establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of monteria, cordoba. methods from september 2009 to december 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of monteria. cerebrospinal fluid (csf) samples from 118 patients were included in the study. clinical aspects, as well as cytochemical and microbiological analysis (gram stain and culture) of csf, were used for selecting the patients. vir ... | 2016 | 28453063 |
| [morphological diagnosis of viral damage to a kidney transplant]. | due to the development of organ transplantation and its accompanying immunosuppression, recent years have been marked by the higher incidence of opportunistic viral infections that are of considerable importance among posttransplantation complications. a variety of viral infections, the possibility of their concomitant or subtle course, and the ability to cause life-threatening complications in recipients make relevant the description of existing diagnostic methods. the article summarizes the da ... | 2016 | 28635942 |
| comparison of circulating tumour cells and circulating cell-free epstein-barr virus dna in patients with nasopharyngeal carcinoma undergoing radiotherapy. | quantification of epstein-barr virus (ebv) cell-free dna (cfdna) is commonly used in clinical settings as a circulating biomarker in nasopharyngeal carcinoma (npc), but there has been no comparison with circulating tumour cells (ctcs). our study aims to compare the performance of ctc enumeration against ebv cfdna quantitation through digital pcr (dpcr) and quantitative pcr. 74 plasma samples from 46 npc patients at baseline and one month after radiotherapy with or without concurrent chemotherapy ... | 2016 | 28442757 |
| inkt cells and their potential lipid ligands during viral infection. | invariant natural killer t (inkt) cells are a unique population of lipid-reactive cd1d-restricted innate-like t lymphocytes. despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging innate and adaptive immunity. diseases ranging from allergy, autoimmunity, and cancer, as well as infectious diseases, including viral infection, have been reported to be influenced by inkt cells. however, it remains unclear how inkt cells are acti ... | 2015 | 26257744 |
| male genital lichen sclerosus. | male genital lichen sclerosus (mglsc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. an afeared complication is squamous cell carcinoma (scc) of the penis. the precise etiopathogenesis of mglsc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (hpv) hepatitis c (hcv), epstein-barr virus (ebv) and borrelia) factors have been implicated: consideration of all the evidence suggests that chronic exp ... | 2015 | 25814697 |