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rapid situation & response assessment of diarrhoea outbreak in a coastal district following tropical cyclone aila in india.background & objectives : cyclone aila hit indian states on eastern coast on may 25, 2009. an investigation was conducted to examine if aila was responsible for increased reporting of diarrhoea cases from the district of east-medinipur in west bengal. identifying causative organisms for diarrhoea and assessing their antibiotic susceptibility profile were other objectives. methods: rapid situation and response assessment technique was employed to triangulate primary and secondary data collected t ...201121537092
development of a new guinea-pig model of shigellosis.shigellosis is a major form of bacillary dysentery caused by shigella spp. to date, there is no suitable animal model to evaluate the protective efficacy of vaccine candidates against this pathogen. here, we describe a successful experimental shigellosis in the guinea-pig model, which has shown the characteristic features of human shigellosis. this model yielded reproducible results without any preparatory treatment besides cecal ligation. in this study, guinea-pigs were discretely infected with ...201121539623
transient suppression of shigella flexneri type 3 secretion by a protective o-antigen-specific monoclonal iga.abstract mucosal immunity to the enteric pathogen shigella flexneri is mediated by secretory iga (s-iga) antibodies directed against the o-antigen (o-ag) side chain of lipopolysaccharide. while secretory antibodies against the o-ag are known to prevent bacterial invasion of the intestinal epithelium, the mechanisms by which this occurs are not fully understood. in this study, we report that the binding of a murine monoclonal iga (igac5) to the o-ag of s. flexneri serotype 5a suppresses activity ...201121610121
dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and std-nmr.carbohydrates are likely to maintain significant conformational flexibility in antibody:carbohydrate complexes. as demonstrated herein for the protective monoclonal antibody f22-4 recognizing the shigella flexneri 2a o-antigen and numerous synthetic oligosaccharide fragments thereof, the combination of molecular dynamics simulations and nmr saturation transfer difference experiments, supported by physicochemical analysis, allows to determine the binding epitope and its various contributions to a ...201121610193
identification of small-molecule inhibitors of yersinia pestis type iii secretion system yscn atpase.yersinia pestis is a gram negative zoonotic pathogen responsible for causing bubonic and pneumonic plague in humans. the pathogen uses a type iii secretion system (t3ss) to deliver virulence factors directly from bacterium into host mammalian cells. the system contains a single atpase, yscn, necessary for delivery of virulence factors. in this work, we show that deletion of the catalytic domain of the yscn gene in y. pestis co92 attenuated the strain over three million-fold in the swiss-webster ...201121611119
a novel compound from the marine bacterium bacillus pumilus s6-15 inhibits biofilm formation in gram-positive and gram-negative species.biofilm formation is a critical problem in nosocomial infections and in the aquaculture industries and biofilms show high resistance to antibiotics. the aim of the present study was to reveal a novel anti-biofilm compound from marine bacteria against antibiotic resistant gram-positive and gram-negative biofilms. the bacterial extract (50 μg ml(-1)) of s6-01 (bacillus indicus = mtcc 5559) showed 80-90% biofilm inhibition against escherichia coli, shigella flexneri, proteus mirabilis and s6-15 (ba ...201121614700
complete (1)h and (13)c nmr chemical shift assignments of mono-, di-, and trisaccharides as basis for nmr chemical shift predictions of polysaccharides using the computer program casper.the computer program casper uses (1)h and (13)c nmr chemical shift data of mono- to trisaccharides for the prediction of chemical shifts of oligo- and polysaccharides. in order to improve the quality of these predictions the (1)h and (13)c, as well as (31)p when applicable, nmr chemical shifts of 30 mono-, di-, and trisaccharides were assigned. the reducing sugars gave two distinct sets of nmr resonances due to the α- and β-anomeric forms. in total 35 (1)h and (13)c nmr chemical shift data sets ...201121621752
synthesis, characterization and biological properties of thienyl derived triazole schiff bases and their oxovanadium(iv) complexes.a new series of biologically active thienyl derived triazole schiff bases and their oxovanadium(iv) complexes have been synthesized and characterized on the basis of physical (m.p., magnetic susceptibility and conductivity), spectral (ir, (1)h and (13)c nmr, electronic and mass spectrometry) and microanalytical data. all the schiff base ligands and their oxovanadium(iv) complexes have been subjected to in vitro antibacterial activity against four gram-negative (escherichia coli, shigella flexner ...201121635212
structure-guided investigation of lipopolysaccharide o-antigen chain length regulators reveals regions critical for modal length control.the o-antigen component of the lipopolysaccharide (lps) represents a population of polysaccharide molecules with a non-random (modal) chain length distribution. the number of the repeat o-units in each individual o-antigen polymer depends on the wzz chain-length regulator, an inner membrane protein belonging to the polysaccharide co-polymerase (pcps) family. different wzz proteins confer vastly different ranges of modal lengths (4 to >100 repeat units) despite having remarkably conserved structu ...201121642455
production of bioactive sheep β-defensin-1 in pichia pastoris.previous research has shown that sheep β-defensin-1 (sbd-1), a small cationic peptide with a broad range of antimicrobial activities, could inhibit the growth of both gram-positive and gram-negative bacteria as well as that of fungi. in order to increase the yield of current ovine defensin purification methods, mature sbd-1 (msbd-1) was added with a 6-his tag on the c-terminus (msbd-1-t) and expressed in pichia pastoris in the presented work. the msbd-1 and msbd-1-t were expressed in the pichia ...201121643707
p62 and ndp52 target intracytosolic shigella and listeria to different autophagy pathways.autophagy is an important mechanism of innate immune defense. we have recently shown that autophagy components are recruited with septins, a new and increasingly characterized cytoskeleton component, to intracytosolic shigella that have started to polymerize actin. on the other hand, intracytosolic listeria avoids autophagy recognition by expressing acta, a bacterial effector required for actin polymerization. here we exploit shigella and listeria as intracytosolic tools to characterize differen ...201121646350
gisul2, a genomic island carrying the sul2 sulphonamide resistance gene and the small mobile element cr2 found in the enterobacter cloacae subspecies cloacae type strain atcc 13047 from 1890, shigella flexneri atcc 700930 from 1954 and acinetobacter baumannii atcc 17978 from 1951. 201121653606
modulation of connexin signaling by bacterial pathogens and their toxins.inherent to their pivotal tasks in the maintenance of cellular homeostasis, gap junctions, connexin hemichannels, and pannexin hemichannels are frequently involved in the dysregulation of this critical balance. the present paper specifically focuses on their roles in bacterial infection and disease. in particular, the reported biological outcome of clinically important bacteria including escherichia coli, shigella flexneri, yersinia enterocolitica, helicobacter pylori, bordetella pertussis, aggr ...201121656255
genetic characteristics and changing antimicrobial resistance among shigella spp isolated from hospitalized diarrhoeal patients in kolkata, india.to study the prevalence pattern and trends in the phenotypic and genetic characteristics of shigellae, we tested 212 isolates isolated from diarrhoeal patients admitted at the infectious diseases hospital, kolkata, india from november 2007 to october 2009. prevalence of shigella spp was more in more than 5 years age group (69%) than the children >5 years age group (31%). serotypes 2a, 3a and untypable isolates of the subtype s. flexneri were frequently detected. increase in the isolation of s. s ...201121659504
the future is cold: cryo-preparation methods for transmission electron microscopy of cells.our knowledge of the organization of the cell is linked, to a great extent, to light and electron microscopy. choosing either photons or electrons for imaging has many consequences on the image obtained, as well as on the experiment required in order to generate the image. one apparent effect on the experimental side is in the sample preparation, which can be quite elaborate for electron microscopy. in recent years, rapid freezing, cryo-preparation and cryo-electron microscopy have been more wid ...201121812762
the vibrio cholerae vctpdgc system transports catechol siderophores and a siderophore-free iron ligand.vibrio cholerae, the causative agent of cholera, has an absolute requirement for iron. it transports the catechol siderophores vibriobactin, which it synthesizes and secretes, and enterobactin. these siderophores are transported across the inner membrane by one of two periplasmic binding protein-dependent abc transporters, vctpdgc or viupdgc. we show here that one of these inner membrane transport systems, vctpdgc, also promotes iron acquisition in the absence of siderophores. plasmids carrying ...201121790806
safety, and immunogenicity of an intranasal shigella flexneri 2a invaplex 50 vaccine.background: shigella flexneri 2a invaplex 50 is a nasally delivered subunit vaccine consisting of a macromolecular complex composed of lps, ipab, ipac and ipad. the current study examined vaccine safety and immunogenicity across a dose range and the clinical performance of a new intranasal delivery device. methods: volunteers (n=36) were randomized to receive vaccine via the dolphin™ (valois of america, congers, new york) intranasal spray device at one of three doses (240, 480, and 690µg) on day ...201121787825
serine protease autotransporters from shigella flexneri and pathogenic escherichia coli target a broad range of leukocyte glycoproteins.the serine protease autotransporters of enterobacteriaceae (spates) are secreted by pathogenic gram-negative bacteria through the autotransporter pathway. we previously classified spate proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). here, we show that pic, a class 2 spate protein produced by shigella flexneri 2a, uropathogenic and enteroaggregative escherichia coli strains, targets a broad range of human leukocyte adhesion proteins. substrate specificity was restricte ...201121768350
lipopolysaccharide core structures and their correlation with genetic groupings of shigella strains; a novel core variant in shigella boydii type 16.bacteria shigella, the cause of shigellosis, evolved from intestinal bacteria escherichia coli. based on structurally diverse o-specific polysaccharide chains of the lipopolysaccharides (o-antigens), three from four shigella species are subdivided into multiple serotypes. the central oligosaccharide of the lipopolysaccharide called core is usually conserved within genus but five core types called r1-r4 and k-12 have been recognized in e. coli. structural data on the shigella core are limited to ...201121752864
outer membrane protein a (ompa) of shigella flexneri 2a, induces protective immune response in a mouse model.in our earlier studies 34 kda outer membrane protein (omp) of shigella flexneri 2a has been identified as an efficient immunostimulant.201121818362
studies on the activity of cyperus rotundus linn. tubers against infectious diarrhea.to study the antidiarrheal activity of the decoction of cyperus rotundus linn. tubers using representative assays of diarrheal pathogenesis and understand its mechanism of action.antibacterial, antigiardial and antirotaviral activities were studied. effect on adherence of enteropathogenic escherichia coli (epec) and invasion of enteroinvasive e. coli (eiec) and shigella flexneri to hep-2 cells was evaluated as a measure of effect on colonization. effect on enterotoxins such as enterotoxigenic e. ...201121713044
recovery and characterization of environmental variants of shigella flexneri from surface water in bangladesh.little is known about the distribution, survival, and transmission of shigella in environmental surface waters. to gain more insight into the environmental biology of shigella we isolated five bacterial strains serotyped as shigella flexneri 2b from a freshwater lake in bangladesh using a modified nutrient broth supplemented with nucleic acid bases. the biochemical properties of the isolates, including inability to ferment lactose and a negative lysine decarboxylase test, indicated common physio ...201121826486
structural and functional studies on the n-terminal domain of the shigella type iii secretion protein mxig.mxig is a single-pass membrane protein that oligomerizes within the inner membrane ring of the shigella flexneri type iii secretion system (t3ss). the mxig n-terminal domain (mxig-n) is the predominant cytoplasmic structure; however, its role in t3ss assembly and secretion is largely uncharacterized. we have determined the solution structure of mxig-n residues 6-112 (mxig-n(6-112)), representing the first published structure of this t3ss domain. the structure shows strong structural homology to ...201121733840
a multifactor regulatory circuit involving h-ns, virf and an antisense rna modulates transcription of the virulence gene icsa of shigella flexneri.the icsa gene of shigella encodes a structural protein involved in colonization of the intestinal mucosa by bacteria. this gene is expressed upon invasion of the host and is controlled by a complex regulatory circuit involving the nucleoid protein h-ns, the arac-like transcriptional activator virf, and a 450ôçënt antisense rna (rnag) acting as transcriptional attenuator. we investigated on the interplay of these factors at the molecular level. dnase i footprints reveal that both h-ns and virf bi ...201121724612
antibacterial dimeric copper(ii) complexes with chromone-derived compounds.a new series of six chromone-derived compounds and their cu(ii) complexes have been synthesized and characterized by their physical, spectral and analytical data. the ligands and their cu(ii) complexes were screened for their in vitro antibacterial activity against four gram-negative (escherichia coli, pseudomonas aeruginosa, salmonella typhi, shigella flexneri) and two gram-positive (bacillus subtilis, staphylococcus aureus) bacterial strains by agar-well diffusion method. the ligands were foun ...201121699463
espg of enteropathogenic and enterohemorrhagic e. coli binds the golgi matrix protein gm130 and disrupts the golgi structure and function.the enteric pathogens enteropathogenic escherichia coli (epec), enterohaemorrhagic e. coli (ehec) and shigella flexneri all translocate at least one effector protein of the espg protein family into host cells via a type iii secretion system (t3ss). the espg family comprises espg, espg2 and vira. from a y2h screen, we identified the golgi matrix protein gm130 as a potential binding partner of espg. we confirmed espg:gm130 protein interaction by affinity co-purification. in co-immunoprecipitation ...201121740499
atomic structure of bacteriophage sf6 tail needle knob.podoviridae are double-stranded dna bacteriophages that use short, non-contractile tails to adsorb to the host cell surface. within the tail apparatus of p22-like phages, a dedicated fiber known as the "tail needle" likely functions as a cell envelope-penetrating device to promote ejection of viral dna inside the host. in sf6, a p22-like phage that infects shigella flexneri, the tail needle presents a c-terminal globular knob. this knob, absent in phage p22 but shared in other members of the p22 ...201121705802
ana president urges empowerment of staff nurses. 20113205705
how important are randomized clinical trials for clinical practice? 20113202012
[influence of the professional motivation in students of various areas in prevention oriented health behavior and the state of their teeth]. 20113256949
[influence of the professional motivation in students of various areas in prevention oriented health behavior and the state of their teeth]. 20113256949
blood culture collection techniques and bacterial contamination. 20113241743
[pulmonary abscess in subjacent congenital malformation in infants]. 20113232901
[caustic burns of the esophagus in childhood. our 14 years' experience].a 14-years revision (1972-1986) is made of 3,600 children attended to after ingesting some type of caustic agent. only 81 were admitted to hospital. we found a predominance in the 1-3 year age group. bleach was the caustic most frequently present but lye accounted for most major lesions. the more relevant symptoms were oropharyngeal lesions (85%), vomiting (26%) and sialorrhea (20%). oropharyngeal burns was the sign most often found in esophageal lesions (45%). the ingestion of ordinary househol ...20113232875
determination of fentin residues in potatoes and celery. 20113232835
the ascertainment sampling problem and estimation of genetic parameters when parental haplotypes are known.comparisons of bias and standard errors of genetic parameter estimates arising from various estimation procedures are made by using contrived genetic data in which parental haplotypes are known in addition to the haplotypes of affected sibs. these comparisons show that knowledge of parental haplotypes can reduce standard errors of genetic parameter estimates by between 10% and 45% as compared to estimates when parental information is not available. the added information does not appear to change ...20113232696
comparison of in vitro dissolution of proprietary methyl dopa preparations. 20113219716
osmotic fragility model for red cell populations.a model that predicts the osmotic fragility curve of a red cell population is developed by relating the critical osmotic pressure to the size distribution of the cells, determined by resistive pulse spectroscopy. two of the parameters involved, namely the normalized osmotic volume correction, b, and the swelling index, k, are previously determined from the experimental average properties of the population. from these values the critical volume of the cell is obtained, and is shown to be 6-12% la ...20113207827
functional and biochemical features of alcohol dehydrogenase in four species of the obscura group of drosophila.the biochemical features of adh of four drosophila species of the obscura group have been studied. the relationship between ethanol tolerance and adh activity has been investigated. propan-2-ol and acetone concentrations have been determined in propan-2-ol treated flies and adh activity has been followed during 96 h of propan-2-ol treatment. data on the adh system confirm constructed phylogenies based on electrophoretic variation and chromosome homologies.20113209073
hla and hydatidiform mole. i. hla and abo antigen frequencies in couples with androgenetic and diandric conceptuses.hla and abo antigen frequencies and mating rates were studied in couples with hydatidiform mole with known genomic origin. hla-a,b antigen frequencies among 60 patients and 59 spouses were not different from those found in the background population, neither in the subgroups regarded alone nor in the entire series. although not significant, an excess of hla-drw6 found in patients with androgenetic conceptions may be related to the anucleate ovi observed with androgenesis. the distribution of abo ...20113194901
[surgery of cholesteatoma ears with good hearing]. 20113219644
[effect of sex steroids on the lipoprotein profile].hyperandrogenemia is associated with relatively high ldl- and low hdl-cholesterol levels, increasing the risk of the development of arteriosclerotic disease. in three women suffering from androgen producing ovarian tumors, this observation could be confirmed. after surgical removal of the ovaries, lipoprotein profiles returned to normal. in contrast, androgens did not affect lipoproteins in two testicular feminized individuals. despite elevated testosterone levels, the lipoprotein profiles were ...20113234712
[function of the kidneys and the renin-aldosterone system in women before and after use of intrauterine contraceptive devices].conflicting opinions exist concerning the use of various birth control methods for women suffering from kidney diseases. some researchers think kidney diseases are a contraindication for the use of iud; since iuds may cause inflammatory processes; others think that preventive therapy of extragenital diseases may make the use of iud possible. the article studies the functional condition of the urinary system and various hormone levels (renin, aldosterone, vasopressin, cortisol) in women using an ...20113322076
sample size: when is enough enough? 20113195627
chordoma in a chronic pain patient.a 60-year-old woman was admitted to the hospital with a recurrence of low back pain. she was begun on a behavior modification pain control program. follow-up x-rays, including ct scan of the lumbosacral spine, showed a large tumor of the l3 vertebra. she subsequently underwent surgical resection of a large chordoma of the l3 vertebra and had good resolution of her back pain.20113160321
[hyperuricemia in the joint syndrome in children]. 20113186400
[usefulness of the diagnosis of grade iii placenta using ultrasonography in the management of prolonged pregnancy]. 20113154276
the use of imipramine in minor motor seizures.a study is presented of 15 pediatric patients treated with imipramine for uncontrolled seizures during the past two years. of these patients, 53% had an initial reduction of seizures of greater than 80%. at one year, 26% were still seizure-free. drop attacks were especially responsive to therapy; 100% (7/7) responded initially to imipramine therapy. most patients studied had been receiving valproate and another major antiepileptic drug prior to imipramine therapy. this study confirms previous re ...20113150277
[disorders of the hypothalamo-hypophyseal-gonadal axis and erectile impotence]. 20113181023
[progress in health services research. diagnostic related groups]. 20113133820
interprofessional perspectives on blindness and low vision. 20113263048
dosimetry for radiolabelled antibodies--macro or micro?three approaches to calculating radiation absorbed doses and answering fundamental questions in radiolabelled antibody therapy are outlined. conventional macroscopic dosimetry is probably not appropriate for calculations on the small scale of normal tissue and tumour volumes that are of interest in therapy. a better though even more traditional approach is to use the results from beta particle dosimetry. these may be shown to apply down to quite small populations of cells. an approach using the ...20113162447
economical with the truth? what to tell the patient in a clinical trial. 20113224193
ifosfamide and vp-16213 combination chemotherapy combined with ablative chemotherapy and autologous marrow transplantation as salvage treatment for malignant lymphoma.eighteen patients with high-grade malignant lymphoma were treated with ifosfamide-vp16213 combinations after failing to respond completely or after relapsing on chop-like therapy. responders to the salvage therapy were subsequently treated with ablative chemotherapy (bcnu, vp-16213, ara-c and melfalan) and autografted. of these 18 patients six were in relapse, six were partial responders and six failed chop-like therapy. there were two complete remissions and seven partial responses to the ifosf ...20113289942
focal spike discharges in children not suffering from clinical epilepsy. 20113149369
clinical predictors of arrhythmia worsening by antiarrhythmic drugs.aggravation of ventricular arrhythmia is a serious, potentially lethal, side effect that can occur with all antiarrhythmic agents. the purpose of this retrospective case-controlled study was to identify clinically useful parameters that would predict aggravation of arrhythmia. patients in whom arrhythmia worsened while taking either quinidine, mexiletine or encainide were selected and matched to 2 similar patients who never developed this drug complication with any antiarrhythmic tested. a numbe ...20113124591
aids policy development within the department of defense. 20113100984
[biology and pathology of the heart and blood vessels. study group on cardiovascular research. vittel, 6-7 mai 1987. abstracts]. 20113113391
stimulation of arachidonic acid release and eicosanoid biosynthesis in an interleukin 2-dependent t cell line.previous studies have provided pharmacologic evidence that t lymphocyte function may be regulated in part by the intracellular production of various arachidonic acid (aa) metabolites in response to cellular stimulation. however, the specific aa metabolic capabilities of homogeneous t cell populations have not been clearly defined. in the present studies, we have employed an accessory cell-free t cell line, ht-2, as a model system for the examination of stimulus-induced eicosanoid biosynthesis in ...20113088127
[clinical experience with high dose rate afterloading interstitial radiation--a preliminary report]. 20113084688
interleukin-2 receptor levels are increased in blood of heart transplant patients during infections.increased levels of soluble interleukin-2 (il-2) receptor were found in plasma of six patients after the heart transplantation. the levels peaked the first week after transplantation and then gradually decreased to normal levels. the moderate episodes of heart transplant rejection did not affect the il-2 receptor levels in comparison to transplant recipients without the rejection episodes. however, the transplant patients with pneumonia had the il-2 receptor levels ten times higher than healthy ...20113123088
departmental divisions and the crisis in undergraduate medical education. 20113133048
triclonal gammopathy in a patient with plasma cell dyscrasia.a triclonal gammopathy is an immunoglobulin abnormality in which three discrete monoclonal subpopulations of immunoglobulin molecules are present in a patient's serum. monoclonal and biclonal gammopathies have been studied extensively, but relatively little is known about the much rarer triclonal gammopathies. the case described below illustrates some of the difficulties that this condition can present to the clinician and the clinical laboratory.20113079680
[hearing disturbances and hearing loss of occupational origin in dentistry]. 20113078965
the treatment of glomerulonephritis in children.the results of treatment of glomerulonephritis (gn) in childhood with oral corticosteroids, immunosuppressive drugs, anticoagulants and the newer regimens of pulsed, high-dose intravenous methylprednisolone and plasma exchange are reviewed and compared with the natural history of the untreated condition. poststreptococcal gn and the nephritis of schönlein-henoch purpura need no specific treatment unless extensive glomerular crescents are present. the progression of mesangiocapillary gn can proba ...20113153019
experience with early quadruple immunosuppressive therapy in heart transplantation. 20113067718
valvular function of the heart after cardiac transplantation. 20113067715
office evaluation and management of the shoulder impingement syndrome.the shoulder impingement syndrome is the most common cause of shoulder pain. a complete office evaluation can be aided by a printed exam sheet. careful consideration of the differential diagnosis is important, often employing the xylocaine injection test. the impingement syndrome responds to conservative treatment the majority of the time. long follow-up determines the need for an invasive evaluation or surgical treatment.20113050719
clinical trials of intramuscular sulprostone for second trimester abortion.the synthetic prostaglandin e2 derivative sulprostone (16-phenoxy-w-17, 18, 19, 20-tetranor) is an effective 2nd trimester abortifacient. this study compares 2 dosage regimens of intramuscular administration. in regimen 1, 9 women with intact pregnancy and 3 with intrauterine fetal death were given sulprostone 500 mcg 3 times at 4-hour intervals to be repeated after 24 hours if abortion did not occur. in regimen 2, 12 women with intact pregnancies were given sulprostone 500 ug every 6 hours for ...20113047304
duplex sonography of the venous system. 20113078970
[pharmacokinetics of non-steroidal anti-inflammatory agents in the elderly]. 20113067421
relation of silent myocardial ischemia to ventricular arrhythmias and sudden death.silent myocardial ischemia is common in the clinical spectrum of coronary disease. ambulatory electrocardiographic monitoring has provided the most objective evidence of silent ischemia, but the phenomenon has also been detected in patients with coronary artery disease through analysis of exercise-induced ischemic st-segment alterations, scintigraphic myocardial perfusion defects and left ventricular wall motion abnormalities. silent myocardial ischemia frequently occurs in patients with stable ...20113055916
dexamethasone suppression test.a connection between a high level of plasma cortisol and psychopathology has long been observed. in depressive patients increased plasma cortisol and non-suppression to the dexamethasone suppression test (dst) has often been described. in this study it was found that endogenously depressed patients more often than non-endogenously depressed patients showed abnormal results to the dst. no difference was found in delta max tsh between suppressors and non-suppressors to the dst.20113067539
investigation of adrenomedullary function in atopic dermatitis.adrenomedullary function in patients with atopic dermatitis was assessed by measurement of plasma levels of catecholamines (adrenalin and noradrenalin) and cyclic amp in response to the stimuli of standing after lying supine, and a 5-min infusion of histamine in the standing position (i.e. histamine plus standing). plasma clearance of adrenalin was examined by measurement of plasma catecholamine and cyclic amp levels following a 15-min intravenous infusion of adrenalin in the supine position. re ...20113040069
does measurement of urinary rare proteins provide diagnostic significance in glomerular diseases? 20113069315
[histamine liberation inhibitors]. 20113131688
radiation of hiroshima and nagasaki builds foundation for risk estimates. 20113897479
alcohol-related symptoms in heterogeneous families of hospitalized alcoholics.heterogeneity in the clinical symptoms of alcohol abuse was examined in 243 men and 305 women from families of hospitalized alcoholics, who had demonstrated different patterns of inheritance of susceptibility to alcoholism. discriminant analysis was utilized to identify nine alcoholic symptoms that distinguished male relatives of alcoholic men from those of alcoholic women. inability to abstain from alcohol, fighting and reckless driving while intoxicated, and alcohol treatment other than alcoho ...20113067614
1,25-dihydroxyvitamin d3 inhibits the clonogenic growth of transformed cells via its receptor.anchorage-independent growth in soft agar is a unique property of transformed cells which is known to be correlated with tumorigenicity. we report here that 1,25-dihydroxyvitamin d3 suppresses colony formation by a number of cultured cancer cell lines in soft agar in a dose dependent manner with an id50 of 5-7 x 10(-10) m. this effect is also achieved with analogues of 1,25-dihydroxyvitamin d3 in accordance with their binding affinity for the hormone's receptor. only cells with 1,25-dihydroxyvit ...20113021122
[on the anniversary. 50 years of the journal of rheumatology. its first editor: public health officer professor dr. med. paul köhler, bad elster]. 20113071033
is hysteroscopy of value in the investigation of female infertility?a prospective multicentre study was designed to ascertain the value of hysteroscopy in the evaluation of female infertility. the study comprises 619 co2 hysteroscopies in women complaining of infertility. four hundred and ninety nine examinations (80%) were performed without anaesthesia or cervical dilatation. twenty eight cases of malformation were diagnosed. adhesions were found in 68 patients (11%), polypi in 56 (9.1%) and submucous fibroids in 51 (8.2%). endometrial hyperplasia was diagnosed ...20113067483
microcystic adenoma of the pancreas: report of a case and review of the literature. 20113064760
[measurement of arterial pressure]. 20113217679
[the extension of deep venous thrombosis treated by intravenous heparin: apropos of 12 cases]. 20113048545
effects of cost sharing on physiological health, health practices, and worry.in a randomized trial of the effects of medical insurance on spending and the health status of the nonaged, we previously reported that patients with limited cost sharing had approximately one-third less use of medical services, similar general self-assessed health, and worse blood pressure, functional far vision, and dental health than those with free care. of the 20 additional measures of physiological health studied here on 3,565 adults, people with cost sharing scored better on 12 measures a ...20113119520
[ultrasonics and directional doppler. study of superficial phlebitis of the lower extremities].the objective of the study was to evaluate the usefulness of ultrasonic methods: ultrasonography and doppler c.w. in the diagnosis of superficial varicose phlebitis. especially, measurement of the venous pressure (v.p.) at the posterior tibial (p.t.) and the greater saphenous vein (g.s.v.) in clino and orthostatism, have proved to be useful. in ten cases, one patient with a varicose in the thigh, was also found to have a femoral vein thrombosis secondary to a deep thrombus entering the junction. ...20113043475
third molar eruption in a 12-year-old girl. 20113165662
guidelines for the use of vitamins, trace elements, calcium, magnesium, and phosphorus in infants and children receiving total parenteral nutrition: report of the subcommittee on pediatric parenteral nutrient requirements from the committee on clinical practice issues of the american society for clinical nutrition. 20113142247
progress in understanding the pathophysiology of treatment-related fluctuations in parkinson's disease. 20113067652
tomorrow's doctors in the making.most medical schools still pay too little attention to primary health care, partly because of a failing in communication between governments and medical education systems. the world federation for medical education has embarked on a major program aimed at helping to improve this situation. reports, materials and surveys are being gathered by the federation's regional associations and regional conferences have been or will be held in africa, the americas, europe, the middle east, southeast asia a ...20113252835
tomorrow's doctors in the making.most medical schools still pay too little attention to primary health care, partly because of a failing in communication between governments and medical education systems. the world federation for medical education has embarked on a major program aimed at helping to improve this situation. reports, materials and surveys are being gathered by the federation's regional associations and regional conferences have been or will be held in africa, the americas, europe, the middle east, southeast asia a ...20113252835
[structural and ultrastructural study of the kidney of the tench, tinca tinca l., after experimental poisoning by the absorption of lead nitrate]. 20113142178
inst-risk ii: an approach to forecasting relative risk of future institutional placement.this article describes a model development process that represents a useful step in classifying populations in terms of risk of institutionalization (inst-risk ii). a four-category risk classification system--"high risk, some risk, low risk, and very low risk"--was developed, based on combinations of measures of functional status, age, health status, demographics, and social supports. our review of variables found by other researchers to be related to high risk of institutional placement, as wel ...20113182290
the biochemistry of endogenous organosulphur compounds.the role and metabolism of methionine and cysteine in mammals are described. an outline of the history of glutathione, of its function in maintaining the thiol status of the cell and of its protective action against oxidative stress, is given. the importance of glutathione reductase, glutathione peroxidases, glutathione-s-transferases in endogenous metabolism and of gamma-glutamyltranspeptidase is described. the relationship between cysteine and glutathione is considered together with the inter- ...20113155361
[ultrasonic capsulotomy]. 20113241728
[artificial nutrition and alcoholic cirrhosis].malnutrition is observed in 60 p. cent of patients with alcoholic cirrhosis. it is characterized by weight loss, hypoproteinemia, and a negative nitrogen balance. it is due to multiple causes. this malnutrition increases the risk of disturbances in the immune system, susceptibility to infection, and postoperative complications. re-nutrition by standard methods of feeding often is inadequate or impractical. use of artificial nutrition is often made necessary either by enteral or parenteral route. ...20113145703
delta-aminolaevulinate synthase: mechanism of its response to malathion. 20113202912
autotransplantation of maxillary canine teeth. a follow-up of 35 cases up to 4 years.35 cases of autotransplantation of nonendodontically treated maxillary canines were followed for up to 4 years and were assessed according to loss of the transplanted tooth, onset of sensibility, mobility, intact lamina dura and presence of tooth resorption. the results of this study compare favourably with other studies and favour the hypothesis that little is to be gained by not endodontically treating autotransplanted teeth immediately after splint removal. it is also suggested that immobiliz ...20113088156
myoclonus and mitochondrial myopathy.the cns diseases that are associated with mitochondrial myopathy have been reviewed in this chapter. the disorders causing myoclonus have been compared to those in which myoclonus has been reported. both groups have been associated with lactate and pyruvate accumulation, and both have a wide spectrum of clinical and pathologic findings. deficiency of components of the respiratory chain has been offered as an explanation for the mitochondrial accumulation in the muscles of these patients. skeleta ...20113080847
sinus node suppression in acute strokes--case reports.the authors report on 5 patients, 4 of them observed over a period of only two months in one community hospital, who developed profound sinus node suppression in the early phase following acute strokes. this complication resulted in the death of 2; in the remaining 3, it was controlled by electrical cardiac pacing or intravenous atropine. in 3 patients, the strokes were due to subarachnoid hemorrhage, and in 2, they were secondary to vascular occlusion. in at least 4 patients, the prognosis seem ...20113189950
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