Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria. | helicobacter pylori infects the stomach of 50% of the population worldwide, thus causing chronic gastritis. although this infection can be cured by antibiotic treatment, therapeutic options are increasingly limited due to the development of resistances. the γ-glutamyl-transpeptidase (ggt) of h. pylori (hpggt) is a virulence factor important for colonization and contributes to bacterial immune evasion. therefore, this enzyme is a potential target for developing new anti-infectives. as species spe ... | 2016 | 27636829 |
| in vitro and in vivo anti-helicobacter activities of eryngium foetidum (apiaceae), bidens pilosa (asteraceae), and galinsoga ciliata (asteraceae) against helicobacter pylori. | this study was performed to evaluate the antimicrobial activities of extracts of bidens pilosa, galinsoga ciliata, and eryngium foetidum against 6 clinical strains of helicobacter pylori in vitro and in vivo. broth microdilution method was used in vitro. in vivo, swiss mice were inoculated with h. pylori and divided into 5 groups; the control group received the vehicle and the four others received 125, 250, and 500 mg/kg of methanol extract of eryngium foetidum and ciprofloxacin (500 mg/kg) for ... | 2016 | 27631003 |
| lipid profile in cardiac syndrome x: association with helicobacter pylori. | chronic inflammation caused by helicobacter pylori (h.pylori) infection has a pathogenic role in cardiac syndrome x (csx). in addition, it has shown that bacterial infection may affect blood lipids. | 2016 | 27630835 |
| heat shock protein association with clinico-pathological characteristics of gastric cancer in jordan : hsp70 is predictive of poor prognosis. | gastric cancer (gc) is a major health problem worldwide and is one of the ten most commonly diagnosed cancers in jordan. gc is usually diagnosed at late aggressive stages in which treatment options are limited. recently, heat shock proteins (hsps) found to be overexpressed in a wide range of malignancies have been considered as promising candidate biomarkers for gc. the aim of this study was to investigate pathogenic roles of a panel of cytosolic hsps including hsp90, hsp70, hsp60 and hsp27 in g ... | 2016 | 27644641 |
| helicobacter pylori infection and polycystic ovary syndrome in adolescent and young adult patients. | polycystic ovary syndrome (pcos) is the most common cause of infertility among women of reproductive age. chronic systemic inflammation has been considered to play a role in the development of pcos. helicobacter pylori has been shown to lead to both local gastric and chronic systemic inflammation. in the light of this, the aim of the present study was to investigate a possible link between h. pylori and pcos. | 2016 | 27642107 |
| response to: comment on "efficacy of 7-day and 14-day triple therapy regimens for the eradication of helicobacter pylori: a comparative study in a cohort of romanian patients". | 2016 | 27641900 | |
| role of regulatory t-cells in different clinical expressions of helicobacter pylori infection. | helicobacter pylori (h. pylori) colonization induces vigorous innate and specific immune responses; however, the infection does not disappear and a chronic active gastritis continues if left untreated. it has been shown that the topographical pattern and immune response of gastritis are the main reasons for the bacteria persistence and the clinical outcome. gastritis due to h. pylori is caused by a complicated interaction among a variety of t cell subsets. regulatory t (treg) cells suppressing t ... | 2016 | 27664483 |
| the gastric acid pocket is attenuated in h. pylori infected subjects. | gastric acid secretory capacity in different anatomical regions, including the postprandial acid pocket, was assessed in helicobacter pylori positive and negative volunteers in a western population. | 2016 | 27663505 |
| correlation of helicobacter pylori infection with development of cardiovascular risk in patients with coronary heart disease in association with type 2 diabetes mellitus. | recent years have demonstrated the possible existence of association between infection helicobacter pylori (hp), coronary heart disease (chd) and type 2 diabetes mellitus (dm-2). the refinement of traditional and non-traditional factors of cardiovascular risk in patients with chd in association with dm-2 of hp-seropositiveis currently important. in this regard, we have studied the influence of hp infection on cardiovascular risk in patients with chd and dm-2. 60 persons with chd in association w ... | 2016 | 27661271 |
| helicobacter pylori infection, gastric cancer and gastropanel. | gastric cancer (gc) is one of the most widespread types of cancer worldwide. helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. at present and in the near future, the most important challenge is and will be the significant reduction of mortality due to gc. that goal can be achieved through the identification of higher-risk patients, such as those with atrophic gastritis, intestinal metaplasia and dysplasia. in this review we intend to discuss the importance of ... | 2016 | 27658162 |
| cyanidin-3-o-glucoside: physical-chemistry, foodomics and health effects. | anthocyanins (acns) are plant secondary metabolites from the flavonoid family. red to blue fruits are major dietary sources of acns (up to 1 g/100 g fw), being cyanidin-3-o-glucoside (cy3g) one of the most widely distributed. cy3g confers a red hue to fruits, but its content in raspberries and strawberries is low. it has a good radical scavenging capacity (rsc) against superoxide but not hydroxyl radicals, and its oxidative potential is ph-dependent (58 mv/ph unit). after intake, cy3g can be met ... | 2016 | 27657039 |
| the role of caga in the gastric biology of helicobacter pylori. | 2016 | 27655809 | |
| native and bone marrow-derived cell mosaicism in gastric carcinoma in h. pylori-infected p27-deficient mice. | chronic helicobacter pylori (h. pylori) infection promotes non-cardia gastric cancer. some mouse models suggest that bone marrow derived cells (bmdc) contribute to helicobacter-associated gastric carcinogenesis. we determined whether this increased susceptibility to helicobacter-induced gastric carcinogenesis of p27-deficient mice is dependent upon their p27-null bmdc or their p27-null gastric epithelial cells. | 2016 | 27655701 |
| helicobacter pylori-negative intestinal-type gastric adenoma successfully treated by endoscopic submucosal dissection: a case report. | a 49-year-old woman underwent an esophagogastroduodenoscopy as part of a health check at our hospital. endoscopic observation revealed a flat elevated lesion 6 mm in diameter in the gastric antrum (paris classification type iia). magnifying endoscopy using narrow-band imaging showed a slightly irregular micro-surface pattern with round and oval pits, as well as a regular micro-vascular pattern without a demarcation line. atrophy and intestinal metaplasia were not recognized in the background gas ... | 2016 | 27652306 |
| downward trend in the prevalence of helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in southeastern china between 2003 and 2012. | this present study aims to determine trends in the prevalence of h. pylori infections in southeastern china between 2003 and 2012, and investigate corresponding changes in the prevalence of upper gastrointestinal diseases. this retrospective study screened 196,442 patients with a mean age of 47.49 ± 14.47 years (age range 5-100 years) in southeastern china, and a total of 134,812 cases of an endoscopy-referral patient population with digestive symptoms between 2003 and 2012 were enrolled. based ... | 2016 | 27652174 |
| synthesis and evaluation of the complex-forming ability of hydroxypyranones and hydroxypyridinones with ni (ii) as possible inhibitors for urease enzyme in helicobacter pylori. | the complex-forming ability of 2-methyl-3-hydroxypyran-4-one (1a), 2-ethyl-3-hydroxypyran-4-one (1b), 1,2-dimethyl-3-hydroxypyridin-4-one (4a) and 1-ethyl-2-methyl-3-hydroxypyridin-4-one (4b) with nickel(ni(ii)) were characterized by infrared, ultraviolet, proton nuclear magnetic resonance spectroscopy and melting point. the mole-ratio of nickel:ligands was analyzed by atomic-absorption-spectrometry. the partition-coefficients (kow) of the compounds were also determined. the binding of ligands w ... | 2016 | 27651814 |
| construction of novel plasmid vectors for gene knockout in helicobacter pylori. | helicobacter pylori infection plays an important role in the etiology of various gastroduodenal diseases. however, pathogenic mechanism of h. pylori is not clear. more potential pathogenic factors need to be further discovered and studied. in this study, two vectors for generating double-crossover recombination gene knockout plasmids in h. pylori were designed based on the backbone of plasmid plyl03. genes on plasmid plyl03 were rearranged, and the redundant sequences were reduced. erythromycin- ... | 2016 | 27650947 |
| association of helicobacter pylori infection and ectopic pregnancy. | to evaluate the importance of cytokine type in embryo implantation in uterus specified and activated macrophages interfere the tube movements and embryo retention in uterine tubes by smooth muscle relaxation and disrupting ciliary function. therefore, increased risk of infection with hp during pregnancy, we investigated relation between helicobacter pylori (hp) infection and prevalence of ectopic pregnancy (ep) in this study. | 2016 | 27648097 |
| sensitivity to nitazoxanide among metronidazole resistant helicobacter pylori strains in patients with gastritis. | in this study, the efficacy of nitazoxanide in the treatment of helicobacter pylori isolates, which were resistant to metronidazole, was examined. | 2016 | 27683646 |
| polyamine- and nadph-dependent generation of ros during helicobacter pylori infection: a blessing in disguise. | helicobacter pylori is a gram-negative bacterium that specifically colonizes the gastric ecological niche. during the infectious process, which results in diseases ranging from chronic gastritis to gastric cancer, the host response is characterized by the activation of the innate immunity of gastric epithelial cells and macrophages. these cells thus produce effector molecules such as reactive oxygen species (ros) to counteract the infection. the generation of ros in response to h. pylori involve ... | 2016 | 27682363 |
| barrett's oesophagus: epidemiology, diagnosis and clinical management. | barrett's oesophagus is a condition characterised by partial replacement of the normal squamous epithelium of the lower oesophagus by a metaplastic columnar epithelium containing goblet cells (intestinal metaplasia). barrett's oesophagus is important clinically because those afflicted are predisposed to oesophageal adenocarcinoma. prevalence surveys suggest that up to 2% of the population may be affected; most will be unaware of their diagnosis. risk factors include age, male sex, gastro-oesopha ... | 2016 | 27681974 |
| metabolic interaction of helicobacter pylori infection and gut microbiota. | as a barrier, gut commensal microbiota can protect against potential pathogenic microbes in the gastrointestinal tract. crosstalk between gut microbes and immune cells promotes human intestinal homeostasis. dysbiosis of gut microbiota has been implicated in the development of many human metabolic disorders like obesity, hepatic steatohepatitis, and insulin resistance in type 2 diabetes (t2d). certain microbes, such as butyrate-producing bacteria, are lower in t2d patients. the transfer of intest ... | 2016 | 27681909 |
| influence of duodenogastric reflux in the gastric mucosa histological changes of rats infected with helicobacter pylori. | to evaluate the influence of duodenal reflux in histological changes of the gastric mucosa of rats infected with helicobacter pylori submitted to pyloroplasty. | 2016 | 27679942 |
| pcr based detection of phase variable genes in pakistani based clinical helicobacter pylori strains. | the distribution pattern of phase-variable genes varies from strain to strain and from region to region. the present study was carried out to investigate the distribution pattern of phase-variable genes within pakistan-based helicobacter pylori strains and to analyze and compare them with strains prevalent in other parts of the world. | 2016 | 27679701 |
| stomach cancer burden in central and south america. | stomach cancer mortality rates in central and south america (csa) are among the highest in the world. we describe the current burden of stomach cancer in csa. | 2016 | 27678324 |
| the burden of oesophageal cancer in central and south america. | oesophageal cancer shows marked geographic variations and is one of the leading causes of cancer death worldwide. we described the burden of this malignancy in central and south america. | 2016 | 27678323 |
| epstein-barr virus-associated gastric cancer and potential mechanisms of oncogenesis. | ebv-associated gastric cancer (ebvagc) comprises about 9% of all cases of gc and constitutes a distinct clinicopathological and molecular entity. the pattern of viral expression in ebvagc cannot be set to any of the previously ebv-associated malignancies. several lines of evidence support that viral expression in ebvagc is characterized by high transcription of the bamh1-a rightward transcript (bart), low-levels of ebna-1 and lack of lmp1. the high transcription activity of the bamh1-a region is ... | 2016 | 27677953 |
| serum antibodies against helicobacter pylori neutrophil activating protein in carriers of il-4 c-590t genetic polymorphism amplify the risk of gastritis and gastric cancer. | gastric cancer arises, mainly, on an inflammatory background. helicobacter pylori neutrophil activating (hp-nap) protein functions as a potent pro-inflammatory mediator. similarly, il-4 plays a critical role in the inflammation pathway, the levels of which are altered by c to t transition at position -590 in its promoter region. here, we have aimed to assess the risk of gastritis and gastric cancer in the co-presence of these two inflammation modulating mediators. | 2016 | 27677314 |
| prevalence of helicobacter pylori infection and its association with lipid profiles. | to evaluate the prevalence of helicobacter pylori (h. pylori, hp) infection in subjects receiving routine physical examination and its associations with age, sex, body mass index (bmi) and lipid profiles. | 2016 | 27677196 |
| pathogenesis and risk factors for gastric cancer after helicobacter pylori eradication. | helicobacter pylori (h. pylori) infection was thought to be the main cause of gastric cancer, and its eradication showed improvement in gastric inflammation and decreased the risk of gastric cancer. recently, a number of studies reported the occurrence of gastric cancer after successful eradication. patients infected with h. pylori, even after eradication, have a higher risk for the occurrence of gastric cancer when compared with uninfected patients. metachronous gastric cancer occurs frequently ... | 2016 | 27672424 |
| detection of helicobacter pylori resistance to clarithromycin and fluoroquinolones in brazil: a national survey. | to evaluate bacterial resistance to clarithromycin and fluoroquinolones in brazil using molecular methods. | 2016 | 27672279 |
| impact of helicobacter pylori on the healing process of the gastric barrier. | to determine the impact of selected well defined helicobacter pylori (h. pylori) antigens on gastric barrier cell turnover. | 2016 | 27672275 |
| regulatory t cells and myeloid-derived suppressor cells in patients with peptic ulcer and gastric cancer. | regulatory t cells (tregs) and myeloid-derived suppressor cells (mdscs) are two main regulatory cells modulating the immune responses in inflammation and cancer. | 2016 | 27671508 |
| rescue therapy for helicobacter pylori eradication: a randomized non-inferiority trial of amoxicillin or tetracycline in bismuth quadruple therapy. | to compare the efficacy and safety of bismuth-containing quadruple therapy with tetracycline or amoxicillin for rescue treatment of helicobacter pylori. | 2016 | 27670603 |
| first-line helicobacter pylori eradication therapies in countries with high and low clarithromycin resistance: a systematic review and network meta-analysis. | to determine the optimal regimen of different first-line helicobacter pylori eradication therapies according to the clarithromycin resistance rate. | 2016 | 27670375 |
| clinical relevance of aberrant polypoid nodule scar after endoscopic submucosal dissection. | to describe a series of patients with aberrant polypoid nodule scar developed after gastric endoscopic submucosal dissection (esd), and to discuss its pathogenesis and clinical management. | 2016 | 27668074 |
| the forgotten virulence factor: the 'non-conventional' hemolysin tlya and its role in helicobacter pylori infection. | helicobacter pylori is a human-specific gram-negative pathogenic bacterium which colonizes the gastric mucosal layer in the stomach causing diseases such as peptic ulcer, adenocarcinoma, and gastric lymphoma. it is estimated that approximately half of the world's population is infected with h. pylori making it the most intensively characterized microbial pathogen up to now. hemolysis has been suggested to significantly contribute to colonization of the stomach and disease progression by h. pylor ... | 2016 | 27686341 |
| halitosis and helicobacter pylori infection: a meta-analysis. | halitosis is used to describe any disagreeable odor of expired air regardless of its origin. numerous trials published have investigated the relation between helicobacter pylori (h pylori) infection and halitosis, and even some regimes of h pylori eradication have been prescribed to those patients with halitosis in the clinic. we conducted a meta-analysis to define the correlation between h pylori infection and halitosis. | 2016 | 27684792 |
| influence of cyp2c19 on helicobacter pylori eradication in brazilian patients with functional dyspepsia. | the aim of this study was to examine the effect of polymorphisms in the cytochrome p450 (cyp) 2c19 gene (cyp2c19) on the helicobacter pylori eradication rate in brazilian patients with functional dyspepsia. adults diagnosed with functional dyspepsia based on the rome iii criteria and infected with h. pylori were recruited to this study. the patients were subjected to gastrointestinal endoscopy and the h. pylori status was defined when both urease test and histopathology results were negative or ... | 2016 | 27706745 |
| analysis of allelic variants of rdxa associated with metronidazole resistance in helicobacter pylori: detection of common genotypes in rdxa by multiplex allele-specific polymerase chain reaction. | resistance to metronidazole (mtz) in helicobacter pylori is a major problem worldwide, especially in developing countries. alterations in mtz nitroreductase enzymes, such as oxygen-insensitive nadph nitroreductase (rdxa) and nadph flavin oxidoreductase (frxa), are the major contributing factors for this resistance. in this study, rdxa and frxa were amplified, sequenced, and analyzed in 34 mtz-resistant h. pylori isolates (mic ≥ 8 μg/ml) using multiple allele-specific polymerase chain reaction (m ... | 2016 | 27706703 |
| a 2016 panorama of helicobacter pylori infection: key messages for clinicians. | the discovery that the bacterium helicobacter pylori (h. pylori) lives in the stomach has rendered out-of-date the concept of inhospitality of the gastric environment. h. pylori is able to survive in this organ through mechanisms of acid resistance and colonization factors. the prevalence of h. pylori infection varies depending on age, socioeconomic class, and country. currently, in the context of a decreased trend in h. pylori prevalence, it is estimated that about 50% of the world's human popu ... | 2016 | 27716738 |
| changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of helicobacter pylori infection. | helicobacter pylori (h. pylori) infection and eradication therapy have been known to influence gastric ghrelin and leptin secretion, which may lead to weight gain. however, the exact relationship between plasma ghrelin/leptin levels and h. pylori infection has remained controversial. the aim of this study was to investigate plasma ghrelin and leptin levels in h. pylori-positive and -negative patients, to compare the two levels of the hormones before and after h. pylori eradication, and to examin ... | 2016 | 27716077 |
| helicobacter pylori antibiotic resistance: what is the future of treatment? | 2016 | 27713814 | |
| diet and helicobacter pylori infection. | helicobacter pylori infection has accompanied man for thousands of years. in some infected patients, a complex and dynamic pathogen-host reaction triggers pathogenic pathways resulting in development, inter alia, of atrophic gastritis, peptic ulcer disease (both gastric and duodenal), gastric adenocarcinoma, and malt lymphoma. large-scale eradication therapy is associated with a rapid increase in antibiotic resistance, gut flora composition disturbances, and increased risk of development, inter ... | 2016 | 27713775 |
| [options for the optimized therapy of helicobacter pylori infection]. | 2016 | 27711944 | |
| proteomics analysis revealed that crosstalk between helicobacter pylori and streptococcus mitis may enhance bacterial survival and reduces carcinogenesis. | helicobacter pylori is the dominant species of the human gastric microbiota and is present in the stomach of more than half of the human population worldwide. colonization by h. pylori causes persistent inflammatory response and h. pylori-induced gastritis is the strongest singular risk factor for the development of gastric adenocarcinoma. however, only a small proportion of infected individuals develop malignancy. besides h. pylori, other microbial species have also been shown to be related to ... | 2016 | 27695448 |
| prevalence of helicobacter pylori prevalence and upper gastrointestinal endoscopy in hiv/aids patients with gastrointestinal symptoms in the university teaching hospitals in cameroon. | to determine the prevalence of helicobacter pylori (h. pylori) infection and of various upper gastrointestinal (gi) lesions in hiv(+) patients with gi symptoms and the relation of h. pylori infection to cd4 cell counts. | 2016 | 27694084 |
| [answer to dr. rinaldo pellicano's letter about the article "maternal infection due to helicobacter pylori does not increase the risk of the infection in the first trimester of the life of their infants"]. | 2016 | 27693055 | |
| a potential impact of helicobacter pylori infection on minimal hepatic encephalopathy pathobiology. | 2016 | 27689208 | |
| a novel potassium-competitive acid blocker improves the efficacy of clarithromycin-containing 7-day triple therapy against helicobacter pylori. | in japan, 7-day triple therapy for helicobacter pylori including clarithromycin (cam) was approved in 2000. however, antibiotic resistance subsequently reduced this rate to an unacceptable level (70%). vonoprazan, an orally bioavailable potassium-competitive acid blocker (p-cab), was approved in japan in 2014. this could improve eradication rates by increasing the intragastric ph, thus increasing bacterial antibiotic susceptibility. this study compared the efficacy of 7-day triple therapies that ... | 2016 | 27689190 |
| nutrition and helicobacter pylori: host diet and nutritional immunity influence bacterial virulence and disease outcome. | helicobacter pylori colonizes the stomachs of greater than 50% of the world's human population making it arguably one of the most successful bacterial pathogens. chronic h. pylori colonization results in gastritis in nearly all patients; however in a subset of people, persistent infection with h. pylori is associated with an increased risk for more severe disease outcomes including b-cell lymphoma of mucosal-associated lymphoid tissue (malt lymphoma) and invasive adenocarcinoma. research aimed a ... | 2016 | 27688750 |
| gastrointestinal disorders associated with migraine: a comprehensive review. | migraine is a recurrent and commonly disabling primary headache disorder that affects over 17% of women and 5%-8% of men. migraine susceptibility is multifactorial with genetic, hormonal and environmental factors all playing an important role. the physiopathology of migraine is complex and still not fully understood. many different neuropeptides, neurotransmitters and brain pathways have been implicated. in connection with the myriad mechanisms and pathways implicated in migraine, a variety of m ... | 2016 | 27688656 |
| helicobacter pylori dna isolation in the stool: an essential pre-requisite for bacterial noninvasive molecular analysis. | real-time polymerase chain reaction (rt-pcr) is a widely used technique for bacterial and viral infection diagnosis. herein, we report our preliminary experience in retrieving h. pylori genetic sequences in stools and analyzing genotypic clarithromycin resistance by rt-pcr (noninvasive), with the aim of comparing this procedure with that performed on biopsy samples (invasive). | 2016 | 27687850 |
| a possible link between gastric mucosal atrophy and gastric cancer after helicobacter pylori eradication. | the effect of h. pylori eradication in gastric cancer prevention can be attributed to the improvement of atrophic gastritis, which is a known risk of gastric cancer. however, gastric cancer has also been diagnosed after long-term h. pylori eradication. this study aimed to clarify the association between gastric atrophy and gastric cancer after h. pylori eradication, including its clinicopathological features. | 2016 | 27706195 |
| serum il-10, mmp-7, mmp-9 levels in helicobacter pylori infection and correlation with degree of gastritis. | helicobacter pylori causes gastric mucosal inflammation and immune reaction. however, the increase of il-10, mmp-7, and mmp-7 levels in the serum is still controversial. the objective of this study was to investigate the serum levels of il-10, mmp-7 & mmp-9 in gastritis patients with h. pylori infection. | 2016 | 27703556 |
| freezing the dynamic gap for selectivity: motion-based design of inhibitors of the shikimate kinase enzyme. | shikimate kinase (sk), the fifth enzyme of the aromatic amino acid biosynthesis, is a recognized target for antibiotic drug discovery. the potential of the distinct dynamic apolar gap, which isolates the natural substrate from the solvent environment for catalysis, and the motion of mycobacterium tuberculosis and helicobacter pylori sk enzymes, which was observed by molecular dynamics simulations, was explored for inhibition selectivity. the results of the biochemical and computational studies r ... | 2016 | 27699905 |
| a comparison between hybrid and concomitant regimens for helicobacter pylori eradication: a randomized clinical trial. | background helicobacter pylori (h. pylori) is one of the most common bacterial infections worldwide. we designed a study to compare the efficacy of 14-day hybrid regimen with 10-day concomitant therapy for h. pylori eradication in iran. methods 252 patients with naïve h. pylori infection were randomly divided to receive either hybrid regimen (pantoprazole 40 mg, and amoxicillin 1 gr twice daily for 14 days, accompanied by clarithromycin 500 mg, and metronidazole 500 mg, twice daily just during t ... | 2016 | 27698972 |
| association between pattern of gastritis and gastroesophageal reflux disease in patients with helicobacter pylori infection. | background reflux disease is a common gastrointestinal problem. the association between reflux disease and gastritis pattern is controversial. | 2016 | 27698970 |
| the effect of probiotic plus prebiotic supplementation on the tolerance and efficacy of helicobacter pylori eradication quadruple therapy: a randomized prospective double blind controlled trial. | background standard anti-helicobacter pylori (h. pylori) treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. we aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti h. p ... | 2016 | 27698967 |
| esomeprazole- or rabeprazole-based triple therapy eradicated helicobacter pylori comparably regardless of clarithromycin susceptibility and cyp2c19 genotypes. | the aim of this study was to assess the efficacy of esomeprazole-based triple therapy compared with rabeprazole-based triple therapy according to cyp2c19 genotype and clarithromycin susceptibility status for first-line eradication therapy of helicobacter pylori (h. pylori) in japan. we enrolled 219 h. pylori-infected patients, and randomly allocated patients to the eac group (esomeprazole 20 mg, clarithromycin 200 mg, amoxicillin 750 mg for one week, with all drugs given twice daily) or rac grou ... | 2016 | 27698544 |
| analysis of negative result in serum anti-h. pylori igg antibody test in cases with gastric mucosal atrophy. | the purpose is to elucidate factors related to negative results of anti-h. pylori antibody test in cases with gastric mucosal atrophy. a total of 859 individuals without past history of eradication therapy for h. pylori (545 males, 314 females; mean age 52.4 years) who underwent an upper gi endoscopy examination and serological test were enrolled as subjects. serological testing was performed using spherelight h. pylori antibody j(®), and endoscopic findings of gastric mucosal atrophy by the cla ... | 2016 | 27698543 |
| the appropriate age to study the incidence of helicobacter pylori infection. | 2016 | 27717520 | |
| high efficacy of gemifloxacin-containing therapy in helicobacter pylori eradication: a pilot empirical second-line rescue therapy. | helicobacter pylori (h pylori) is a common gastric pathogen which is associated with chronic gastritis, peptic ulcer, and gastric cancer. it has worldwide distribution with higher incidence in developing countries. gemifloxacin is a fluoroquinolone antibiotic with documented in vitro activity against h pylori. considering that there is no clinical data to verify gemifloxacin efficacy in h pylori eradication, this pilot clinical trial was designed. | 2016 | 27759625 |
| effectiveness of systematic alphanumeric coded endoscopy for diagnosis of gastric intraepithelial neoplasia in a low socioeconomic population. | background and study aims: in the western world, gastric cancer (gc) usually presents at an advanced stage, carrying a high mortality rate. studies have reported that 14 % to 26 % of gcs are missed at endoscopy up to 3 years before diagnosis. systematic alphanumeric coded endoscopy (sace) has been proposed to improve quality of esophagogastroduodenoscopy (egd) by facilitating a complete examination of the upper gastrointestinal tract. this prospective cross-sectional study was designed to determ ... | 2016 | 27747283 |
| a 10-year review of surgical management of complicated peptic ulcer disease from a single center: is laparoscopic approach the future? | the discovery of helicobacter pylori (h. pylori) as the culprit in peptic ulcer disease (pud) has revolutionized its management. despite the presence of effective drug treatments and an increased understanding of its etiology, the percentage of patients who require emergent surgery for complicated disease remains constant at 7% of hospitalized patients. this study aims at reviewing the incidence of complicated pud and analyze changes in surgical management. | 2016 | 27661205 |
| gut microbiome and gastrointestinal cancer: les liaisons dangereuses. | gastrointestinal (gi) cancers are the leading cause of mortality worldwide. these cancers are the end result of a complex interplay between gene and environment. bacteria, parasites, and viruses have been implicated in some cancers. recent data have put at focus the gut microbiome as the key player firing tumorigenesis. experimental and human studies have provided evidence on the role of microbiota in cancer development. although subject to changes in different settings such as antibiotic treatm ... | 2016 | 27741173 |
| mixed infections of helicobacter pylori isolated from patients with gastrointestinal diseases in taiwan. | background. persistent helicobacter pylori infection may induce several upper gastrointestinal diseases. two major virulence factors of h. pylori, vacuolating cytotoxin a (vaca) and cytotoxin-associated gene a (caga), are thought to be associated with the severity of disease progression. the distribution of vaca and cag-pathogenicity island (cag-pai) alleles varies in h. pylori isolated from patients in different geographic regions. aim. to assess the association between mixed infection of h. py ... | 2016 | 27738429 |
| performances of four helicobacter pylori serological detection kits using stool antigen test as gold standard. | the aim was to determine the performances of four helicobacter pylori serological detection kits in different target groups, using amplified ideia™ hp star™ as gold standard. kits studied were rapid immunochromatoghraphic hexagon, helicoblot 2.1, an eia igg kit and eia iga kit. | 2016 | 27736910 |
| towards a healthy stomach? helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a swedish community. | in western countries the prevalence of helicobacter pylori (h. pylori) infection may be declining but there is a lack of recent longitudinal population studies. we evaluated the changing epidemiology over a 23-year period in sweden. | 2016 | 27733911 |
| genetic basis of gastric cancer. | gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. the environmental factors mainly include dietary, helicobacter pylori infection and family history of gastric cancer. genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, dna repair genes and signaling molecules. this paper summarizes the susceptible genes of gastric ... | 2016 | 27733228 |
| radiation therapy for gastric mucosa-associated lymphoid tissue lymphoma: dose-volumetric analysis and its clinical implications. | to assess the clinical outcomes of radiotherapy (rt) using two-dimensional (2d) and three-dimensional conformal rt (3d-crt) for patients with gastric mucosa-associated lymphoid tissue (malt) lymphoma to evaluate the effectiveness of involved field rt with moderate-dose and to evaluate the benefit of 3d-crt comparing with 2d-rt. | 2016 | 27730803 |
| sequence analysis of hypothetical proteins from helicobacter pylori 26695 to identify potential virulence factors. | helicobacter pylori is a gram-negative bacteria that is responsible for gastritis in human. its spiral flagellated body helps in locomotion and colonization in the host environment. it is capable of living in the highly acidic environment of the stomach with the help of acid adaptive genes. the genome of h. pylori 26695 strain contains 1,555 coding genes that encode 1,445 proteins. out of these, 340 proteins are characterized as hypothetical proteins (hp). this study involves extensive analysis ... | 2016 | 27729842 |
| deletion of iqgap1 promotes helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro. | helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. iqgap1, a scaffolding protein of the adherens junctions interacting with e-cadherin, regulates cellular plasticity and proliferation. in mice, iqgap1 deficiency leads to gastric hyperplasia. the aim of this study was to elucidate the consequences of iqgap1 deletion on h. pylori-induced gastric carcinogenesis.transgenic mice deleted for iqgap1 and wt littermates were infected with helicob ... | 2016 | 27729612 |
| malignant transformation of a gastric hyperplastic polyp in a context of helicobacter pylori-negative autoimmune gastritis: a case report. | gastric foveolar hyperplastic polyps (gfhps) are common findings in clinical practice. gfhps commonly arise in a background of chronic atrophic gastritis, including autoimmune gastritis (type a gastritis), and have a potential risk of malignant transformation. | 2016 | 27729029 |
| eosinophilic esophagitis: demographic, clinical, endoscopic, histological and allergological characteristics in children and teenagers in a region of central spain. | eosinophilic esophagitis (eoe) is a chronic inflammatory emerging disease of the oesophagus with immunoallergic aetiology. until now, few studies about this disease in children and adolescents have been published objectives: to study the demographic, clinical, serologic, endoscopic-histological and allergologic characteristics of the patients and their atopic and digestive comorbidities. | 2016 | 27727140 |
| additive interactions between prkaa1 polymorphisms and helicobacter pylori caga infection associated with gastric cancer risk in koreans. | although several studies reported genetic polymorphisms in protein kinase amp-activated alpha 1 catalytic subunit (prkaa1) and their associations with gastric cancer risk, few have evaluated associations between helicobacter pylori infection and prkaa1 gene-environment interactions. here, we evaluated the effects of interactions between h. pylori infection and prkaa1 polymorphisms on gastric cancer risk in koreans. in this hospital-based case-control study, prkaa1 genotypes were analyzed and h. ... | 2016 | 27726301 |
| microrna-155 in exosomes secreted from helicobacter pylori infection macrophages immunomodulates inflammatory response. | exosomes containing microrna-155 act as molecule carriers during immune cell-cell communication and play an important role in the inflammatory response of h. pylori infection macrophages. previous reports have found that mir-155 was over-expressed in h. pylori infection macrophages, but the significance of which is still unknown. in this study, we analyzed the impact of mir-155 loaded in exosomes derived from macrophages to the inflammatory response of h. pylori infection macrophages and possibl ... | 2016 | 27725852 |
| [stress ulcer prophylaxis: are ppis truly superior compared to h2 receptor antagonists?] | the s2k-guideline "helicobacter pylori and gastroduodenal ulcer disease" offers a statement and comment on the subject of stress ulcer prophylaxis that need a critical response. | 2016 | 27723909 |
| [diagnostic and therapeutic management of helicobacter pylori: a survey among german gastroenterologists in private practice]. | purpose: the acceptance and realization of clinical guidelines in daily routine practice is unknown. the aim of this study was to evaluate the behaviour of private gastroenterologists in germany with respect to the diagnostic and therapeutic management of h. pylori infection in times of increasing antibiotic resistance. methods: between 12/2014 and 02/2015 a standardized questionnaire with 19 multiple choice questions were sent to 1507 private gastroenterologists in germany. the data were electr ... | 2016 | 27723904 |
| efficacy of probiotic supplementation therapy for helicobacter pylori eradication: a meta-analysis of randomized controlled trials. | traditional helicobacter pylori (h. pylori) eradication therapies have shown efficacies below 80% in several studies, and their use has been accompanied by antibiotic-related side effects. some recent studies have reported that supplementing standard therapies with probiotics can improve the efficacy and tolerability of helicobacter pylori eradication therapy. | 2016 | 27723762 |
| etiology and prevention of gastric cancer. | gastric cancer is a heterogeneous malignant disease associated with environmental and genetic predisposing factors. while gastric cancer incidence and mortality fell greatly globally over the past decades, it remains the fourth cause of cancer-related death worldwide. thus, prevention of gastric cancer is still a major strategy for improvement of gastric cancer prognosis. | 2016 | 27722154 |
| helicobacter pylori infection and colorectal carcinoma risk: a meta-analysis. | helicobacter pylori infection and colorectal cancer risk are not clear. we perform this meta-analysis to further evaluate the association between h. pylori infection and colorectal cancer susceptibility. | 2016 | 27721244 |
| salt-inducible protein splicing in cis and trans by inteins from extremely halophilic archaea as a novel protein-engineering tool. | intervening protein sequences (inteins) from extremely halophilic haloarchaea can be inactive under low salinity but could be activated by increasing the salt content to a specific concentration for each intein. the halo-obligatory inteins confer high solubility under both low and high salinity conditions. we showed the broad utility of salt-dependent protein splicing in cis and trans by demonstrating backbone cyclization, self-cleavage for purification, and scarless protein ligation for segment ... | 2016 | 27720988 |
| promising in vitro and in vivo inhibition of multidrug-resistant helicobacter pylori by linezolid and novel oxazolidinone analogues. | the objective of this study was to investigate the prevalence of drug-resistant helicobacter pylori in beijing tian tan hospital (beijing, china) and to determine the susceptibility of h. pylori to linezolid and novel oxazolidinone analogues. minimum inhibitory concentrations (mics) of amoxicillin, clarithromycin, metronidazole, ciprofloxacin, tetracycline and levofloxacin against h. pylori were determined by etest. the in vitro antibacterial activities of linezolid and novel oxazolidinone analo ... | 2016 | 27718441 |
| (18)f-fdg uptake in the stomach on screening pet/ct: value for predicting helicobacter pylori infection and chronic atrophic gastritis. | the aim of this study was to determine the value of (18)f-fdg uptake on screening pet/ct images for the prediction of helicobacter pylori (h. pylori) infection and chronic atrophic gastritis. | 2016 | 27756255 |
| characterization of lactobacillus salivarius strains b37 and b60 capable of inhibiting il-8 production in helicobacter pylori-stimulated gastric epithelial cells. | interleukin (il)-8 is the key agent for initiating an inflammatory response to infection with helicobacter pylori. some strains of lactobacillus spp. are known to colonize the stomach and suppress inflammation caused by h. pylori. in this study, we characterized two gastric-derived lactobacilli, lactobacillus salivarius (ls) strains b37 and b60, capable of inhibiting h. pylori-induced il-8 production by gastric epithelial cells. | 2016 | 27756217 |
| clinicopathological features of gastric adenocarcinoma of the fundic gland (chief cell predominant type) by retrospective and prospective analyses of endoscopic findings. | gastric adenocarcinoma of the fundic gland type (chief cell predominant type) (ga-fg-ccp) is a variant of gastric adenocarcinoma with chief cell differentiation. ga-fg-ccp is rare and not well understood. the present study aimed to investigate the clinicopathological features of ga-fg-ccp using retrospective and prospective analyses of endoscopic findings. | 2016 | 27129734 |
| epigenetic silencing of mir-124 prevents spermine oxidase regulation: implications for helicobacter pylori-induced gastric cancer. | chronic inflammation contributes to the development of various forms of cancer. the polyamine catabolic enzyme spermine oxidase (smox) is induced in chronic inflammatory conditions, including helicobacter pylori-associated gastritis, where its production of hydrogen peroxide contributes to dna damage and subsequent tumorigenesis. microrna expression levels are also altered in inflammatory conditions; specifically, the tumor suppressor mir-124 becomes silenced by dna methylation. we sought to det ... | 2016 | 27041578 |
| the relationship between recurrent aphthous stomatitis, and periodontal disease and helicobacter pylori infection. | recurrent aphthous stomatitis (ras) is a common oral mucosal disease with unknown etiology. this cross-sectional study aimed to test the hypothesis that helicobacter pylori and periodontal disease might play an etiological role in ras. | 2016 | 26733449 |
| os 10-02 effects of helicobacter pylori infection on atherosclerosis with hypertension and type 2 diabetes mellitus in aged population. | to explore the effects of helicobacter pylori infection on atherosclerosis in patients with hypertension and type 2 diabetes mellitus (t2dm). | 2016 | 27753963 |
| in vitro and in vivo anti-helicobacter pylori activities of centella asiatica leaf extract. | helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. however, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. the aim of this study was to investigate the activities of centella asiatica leaf extract (cae) against h. pylori both in vitro and in vivo. the minimum inhibitory concentrations (mics) against 55 clinically isolated strains of ... | 2016 | 27752495 |
| usefulness of endoscopic imaging to visualize regional alterations in acid secretion of noncancerous gastric mucosa after helicobacter pylori eradication. | endoscopic diagnosis of gastric cancer (gc) that emerges after eradication of helicobacter pylori may be affected by unique morphological changes. using comprehensive endoscopic imaging, which can reveal biological alterations in gastric mucosa after eradication, previous studies demonstrated that congo red chromoendoscopy (cre) might clearly show an acid non-secretory area (ana) with malignant potential, while autofluorescence imaging (afi) without drug injection or dyeing may achieve early det ... | 2016 | 27752392 |
| [evaluation and establishment of mongolian gerbil model of long-term infection of helicobacter pylori with highly-expressed thioredoxin-1 gene]. | to establish a mongolian gerbils model by long-term infection of helicobacter pylori (hp) with highly-expressed thioredoxin-1 (trx1) gene and to investigate the histopathological findings of gastric mucosa in mongolian gerbils. | 2016 | 27752153 |
| standard triple therapy versus sequential therapy for eradication of helicobacter pylori in treatment naïve and retreat patients. | untreated helicobacter pylori infection causes increased risk of gastric cancer, gi morbidity and mortality. standard treatment for eradication of helicobacter pylori infection, is the triple therapy which consists of a proton pump inhibitor; together with two antibiotics (amoxicillin 1000mg with clarithromycin 500mg or metronidazole 400mg) given twice daily for 7-14days. recent evidence revealed, that cure rates of helicobacter pylori infection with triple therapy had fallen below satisfactory ... | 2016 | 27665525 |
| helicobacter pylori eradication with proton pump inhibitors or potassium-competitive acid blockers: the effect of clarithromycin resistance. | vonoprazan is a novel potassium-competitive acid blocker (p-cab) recently approved for helicobacter pylori eradication therapy in japan. | 2016 | 27659671 |
| association of helicobacter pylori with hepatobiliary stone disease, a prospective case control study. | hepatobiliary stone disease is one of the most common surgical conditions worldwide. there are multiple causative agents responsible for the formation of hepatobiliary stones, and bacterial infection is one of them. the presence of helicobacter dna species has been investigated in the biliary epithelium of patients with biliary diseases. however, conflicting results have been observed that may have been due to the small number of subjects studied, difficulty in obtaining a healthy control group, ... | 2016 | 27633033 |
| hedgehog signaling in the stomach. | the hedgehog (hh) signaling pathway not only plays a key part in controlling embryonic development, but in the adult stomach governs important cellular events such as epithelial cell differentiation, proliferation, gastric disease, and regeneration. in particular, sonic hedgehog (shh) signaling has been well studied for its role in gastric physiology and pathophysiology. shh is secreted from the gastric parietal cells and contributes to the regeneration of the epithelium in response to injury, o ... | 2016 | 27750091 |
| pathogenic mechanisms of the oncoprotein caga in h. pylori-induced gastric cancer (review). | infection with helicobacter pylori is the strongest risk factor for the development of chronic gastritis, gastric ulcer and gastric carcinoma. the majority of the h. pylori-infected population remains asymptomatic, and only 1% of individuals may progress to gastric cancer. the clinical outcomes caused by h. pylori infection are considered to be associated with bacterial virulence, genetic polymorphism of hosts as well as environmental factors. most h. pylori strains possess a cytotoxin-associate ... | 2016 | 27748858 |
| helicobacter pylori adhesin hopq engages in a virulence-enhancing interaction with human ceacams. | helicobacter pylori specifically colonizes the human gastric epithelium and is the major causative agent for ulcer disease and gastric cancer development. here, we identify members of the carcinoembryonic antigen-related cell adhesion molecule (ceacam) family as receptors of h. pylori and show that hopq is the surface-exposed adhesin that specifically binds human ceacam1, ceacam3, ceacam5 and ceacam6. hopq-ceacam binding is glycan-independent and targeted to the n-domain. h. pylori binding induc ... | 2016 | 27748768 |
| helicobacter pylori exploits human ceacams via hopq for adherence and translocation of caga. | helicobacter pylori (hp) strains that carry the cag type iv secretion system (cag-t4ss) to inject the cytotoxin-associated antigen a (caga) into host cells are associated with peptic ulcer disease and gastric adenocarcinoma. caga translocation by hp is mediated by β1 integrin interaction of the cag-t4ss. however, other cellular receptors or bacterial outer membrane adhesins essential for this process are unknown. here, we identify the hopq protein as a genuine hp adhesin, exploiting defined memb ... | 2016 | 27748756 |