Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| nucleotide sequence and transcriptional regulation of a positive regulatory gene of shigella dysenteriae. | a 1,937 bp psti-hindiii fragment containing the ipar locus was cloned from the large invasion plasmid of shigella dysenteriae cg097, and its nucleotide sequence was completely determined. the ipar protein (35 kda, calculated from the dna sequence) was synthesized in escherichia coli chi 1411 minicells containing the 1,937-bp psti-hindiii fragment. to determine the regulatory role of ipar for ipa genes, we applied genetic complementation experiments using chloramphenicol acetyltransferase (cat) a ... | 1992 | 1541532 |
| shigella-specific iga in saliva of children with bacillary dysentery. | to study the secretory immune response after shigella infection, the anti-lipopolysaccharide and anti-shiga-toxin response in saliva, obtained from children with confirmed shigellosis and healthy children, were determined by enzyme-linked immunosorbent assay and by western blot. children with infection showed high titers compared to healthy controls. after shigella dysenteriae type 1 infection a significant change in titer could be observed in a large number of cases, in contrast to shigella fle ... | 1992 | 1547024 |
| drug resistance and plasmid profile of shigellae in taiwan. | one hundred and twenty-eight shigella strains isolated from newborn and infant human faecal specimens at kaohsiung medical college hospital in taiwan were serogrouped, serotyped and examined for drug-resistance patterns and for the presence of plasmids. forty-seven per cent of the isolates were found to belong to the shigella sonnei serogroup, 41% to the s. flexneri group, 9% to the s. boydii group and 3% to the s. dysenteriae group. the serotype with the greatest number of strains was s. sonnei ... | 1992 | 1547844 |
| acamprosate modulates synaptosomal gaba transmission in chronically alcoholised rats. | male sprague-dawley rats were pulmonary alcoholised for 30 days. six were treated with acamprosate (400 mg/kg/day, po) during alcoholisation. the control nonalcoholised group also received acamprosate (400 mg/kg/day, po) during the 30 days. at the end of the experiment, brains areas (cortex, hippocampus, thalamus, striatum, and olfactory bulbs) were dissected for the study of synaptosomal 3h-gaba uptake. in another experiment, gaba levels were determined in the same areas using hplc with electro ... | 1992 | 1594633 |
| copulatory analgesia in male rats ensues from arousal, motor activity, and genital stimulation: blockage by manipulation and restraint. | the effect of copulation on the vocalization threshold to tail shock (vtts) was assessed in freely-moving, sexually experienced, wistar male rats. mean vtts during the first copulation was 40% above the baseline values and slightly decreased during the first postejaculatory interval (pei; 28% above baseline). vtts mean values further increased during the second copulatory series (93% above baseline and 63% during the pei). testing at the same intervals in noncopulating rats did not induce analge ... | 1992 | 1594675 |
| antimicrobial resistance of shigella isolates in bangladesh, 1983-1990: increasing frequency of strains multiply resistant to ampicillin, trimethoprim-sulfamethoxazole, and nalidixic acid. | the susceptibility to ampicillin and trimethoprim-sulfamethoxazole (tmp-smz) was determined for 15,824 isolates of shigella obtained from patients attending a treatment center in dhaka, bangladesh, from 1983 through 1990 and for 520 isolates obtained during community surveys from 1988 through 1990. susceptibility to nalidixic acid was determined for isolates obtained after 1985. in 1983 13% of isolates were resistant to ampicillin, 23.5% to tmp-smz, and 0.8% to both drugs. by 1990 51.2% of isola ... | 1992 | 1600006 |
| fluorescent antibody staining test for rapid diagnosis of shigella dysenteriae 1 infection. | an indirect fluorescent antibody test for rapid detection of shigella dysenteriae 1 in diarrheal stools was developed. a diagnosis could be made within 90 min of submission of specimens to the laboratory. on comparison with culture results, the test had a sensitivity of 92%, a specificity of 93%, and positive and negative predictive values of 94% and 92%, respectively. | 1992 | 1611852 |
| adhesion of shigella dysenteriae type 1 and shigella flexneri to guinea-pig colonic epithelial cells in vitro. | adhesion of bacteria to guinea-pig colonic epithelial cells in vitro was inhibited by fucose with all the four strains tested (two of shigella dysenteriae type 1 and two of s. flexneri). n-acetyl neuraminic acid and n-acetyl mannosamine also caused inhibition, suggesting a multiplicity of receptors on the epithelial cell. congo-red binding of the strains correlated with their adhesive ability, whereas haemagglutination of rabbit erythrocytes by the bacteria did not. | 1992 | 1613779 |
| antibodies to shiga holotoxin and to two synthetic peptides of the b subunit in sera of patients with shigella dysenteriae 1 dysentery. | acute- and convalescent-phase sera from 18 thai patients and convalescent-phase sera from two israeli patients and one bangladeshi patient with shigella dysenteriae 1 (shiga) dysentery were tested by enzyme-linked immunosorbent assay to detect antibodies that bind s. dysenteriae lipopolysaccharide (lps), shiga holotoxin, or two synthetic peptides representing epitopes from the b subunit of shiga toxin. paired sera from 24 maryland adults with shigella flexneri 2a or shigella sonnei diarrhea serv ... | 1992 | 1629317 |
| bilateral facial palsy caused by the borrelia spirochete. | a case of total left peripheral and partial right peripheral facial palsy caused by the borrelia spirochete is presented. the diagnosis was confirmed by the history of the tick-bites and elevated titers of igg in serum and cerebrospinal fluid. | 1992 | 1632233 |
| influence of oxygen radicals generating agents on eicosanoid metabolism of human endothelial cells. | human umbilical venous endothelial cells were incubated with increasing concentrations (0.001-10 mmol/l) of h202 or cumene hydroperoxide. pgi2 was released within the first five minutes, whereas a significant increase in txa2-release was not observed before 10 minutes after stimulation. furthermore the content of intracellular atp and the level of cytosolic free ca2+ were measured. doses of 0.01 mmol/l h202 or cumene hydroperoxide increased the intracellular atp-level. doses higher than 0.1 mmol ... | 1992 | 1636164 |
| construction of stable lamb-shiga toxin b subunit hybrids: analysis of expression in salmonella typhimurium aroa strains and stimulation of b subunit-specific mucosal and serum antibody responses. | the complete shiga toxin b subunit and two n-terminal segments of the b subunit have been inserted into a cell surface exposed loop of the lamb protein, and expression of the hybrid proteins from three different promoter systems, i.e., (i) an in vitro-inducible tac promoter that provides high-level expression, (ii) the iron-regulated aerobactin promoter presumably induced in vivo under the iron-limiting conditions of the intestinal mucosal environment, and (iii) a synthetic, modified beta-lactam ... | 1992 | 1639503 |
| crystal structure of the cell-binding b oligomer of verotoxin-1 from e. coli. | the shiga toxin family, a group of cytotoxins associated with diarrhoeal diseases and the haemolytic uraemic syndrome, includes shiga toxin from shigella dysenteriae type 1 and verotoxins produced by enteropathogenic escherichia coli. the family belongs to the a-b class of bacterial toxins, which includes the cholera toxin family, pertussis and diphtheria toxins. these toxins all have bipartite structures consisting of an enzymatic a subunit associated with a b oligomer which binds to specific c ... | 1992 | 1741063 |
| possible mechanisms underlying the slow lactose fermentation phenotype in shigella spp. | a southern hybridization analysis revealed that the region homologous to escherichia coli lacz was present on the chromosomal dnas of beta-galactosidase-positive shigella strains, such as shigella dysenteriae serovar 1 and shigella sonnei strains, whereas this region was absent from chromosomal dnas of beta-galactosidase-negative strains of shigella flexneri and shigella boydii. we found that the lacy-a region was deficient in s. dysenteriae serovar 1 and believe that this is the reason for the ... | 1991 | 1746953 |
| antimicrobial resistance trends of shigellae isolates from calabar, nigeria. | during a 3-year study (january 1986-december 1988), stools of 2200 diarrhoeal or dysenteric patients were examined by culturing and 108 (4.9%) were found positive for shigellae. shigella flexneri was the commonest species isolated (54.6%), followed by sh. dysenteriae (24.1%). patients aged less than or equal to 15 years accounted for 51.4% of cases. shigellae over the 3 years showed high and sometimes rising resistance to ampicillin, chloramphenicol, streptomycin and cotrimoxazole and complete r ... | 1991 | 1758013 |
| amylin is more potent and more effective than glucagon in raising plasma glucose concentration in fasted, anesthetized rats. | amylin is a 37 amino-acid peptide secreted from the pancreatic beta-cells. it has actions on carbohydrate metabolism in vivo, including elevation of blood glucose. in this study, the hyperglycemic effect of intravenous bolus injections of amylin was compared with similar injections of glucagon in 20-hour fasted rats lightly anesthetized with halothane. administered doses ranged from 0.01 micrograms to 1000 micrograms (about 7 pmol/kg--750 nmol/kg for amylin and 8 pmol/kg--800 pmol/kg for glucago ... | 1991 | 1764079 |
| the pathogenic mechanisms of shiga toxin and the shiga-like toxins. | it is now well documented that some enteric bacteria which cause diarrhoeal and/or dysenteric disease produce, at high levels, one or more of a family of protein toxins referred to as shiga toxin and shiga-like toxins (slts; alternatively called verocytotoxins or vts). within the past few years, there have been considerable advancements made in our understanding of the biochemistry and molecular biology of shiga toxin and slts. however, the precise role of the toxins in mediating colonic disease ... | 1991 | 1766367 |
| nucleotide sequence of the ipabcd structural genes of shigella dysenteriae. | a 9 kb ecori and two psti fragments from the virulence plasmid of shigella dysenteriae cg097 were shown to contain all ipa genes by probing with shigella flexneri ipab, -c, -d and -a gene probes. the dna sequences of s. dysenteriae ipabc genes were very similar to those of s. flexneri m90t and s. flexneri ysh6000, but ipad differed by 22 codons from that of s. flexneri. the differences in ipad may account for the different in vitro host specificities shown by s. dysenteriae and s. flexneri. the ... | 1991 | 1766387 |
| structure of the o-antigen of francisella tularensis strain 15. | the o-specific polysaccharide, obtained by mild acid degradation of the lipopolysaccharide of francisella tularensis strain 15, contained 2-acetamido-2,6-dideoxy-d-glucose (d-quinac), 4,6-dideoxy-4-formamido-d-glucose (d-qui4nfm), and 2-acetamido-2-deoxy-d-galacturonamide (d-galnacan) in the ratios 1:1:2. tri- and tetra-saccharide fragments were obtained on treatment of the polysaccharide with anhydrous hydrogen fluoride and partial hydrolysis with 0.1 m hydrochloric acid, respectively. on the b ... | 1991 | 1769021 |
| shigella dysenteriae 60r strain adheres to and invades tissue culture cells in the absence of virulence plasmid. | evidence is presented that a high level shiga toxin-producing strain shigella dysenteriae 60r adheres to and invades the epithelial cell lines hct8 and henle 407. the invasive phenotype of s. dysenteriae 60r differs in four ways from the heretofore studied invasive shigella phenotypes. first, s. dysenteriae 60r lacks the virulence plasmid characteristic of other invasive shigella spp. and enteroinvasive escherichia coli. second, hybridization studies show that the known ipa genes are neither pre ... | 1991 | 1769541 |
| mosaic trisomy 8 associated with jejunal duplication. | 1991 | 1773546 | |
| rapid purification of hepatitis b virus dna from serum. | we describe two rapid, simple, and reliable procedures for routine purification of hepatitis b virus (hbv) dna from serum. hbv dna could be purified from 24 serum samples in 1.5 to 2 h and was recovered in the initial reaction vessel. both procedures have in common that hbv dna is complexed with silica particles in the chaotropic agent guanidinium thiocyanate (guscn) but differ in lysis conditions and in the conditions used to elute hbv dna from the silica particles after purification of the sil ... | 1991 | 1774300 |
| detection of shiga toxin-producing shigella dysenteriae type 1 and escherichia coli by using polymerase chain reaction with incorporation of digoxigenin-11-dutp. | a technique has been developed for the detection of shiga toxin- and shiga-like toxin type i (sht/slt-i)-producing shigella dysenteriae type 1 and escherichia coli by using the polymerase chain reaction with the incorporation of digoxigenin-11-dutp. target dna liberated from whole cells was amplified, using primer pairs homologous to the a-subunit genes of sht/slt-i. the ttp analog digoxigenin-11-dutp was incorporated into the reaction mixture, permitting nonradioactive labeling of the amplified ... | 1991 | 1774316 |
| environmental signals induce major changes in virulence of shigella spp. | growth conditions play a major role in expression of virulence by shigella spp. both in vitro (adherence and internalization in eukaryotic host cells) and in vivo (keratoconjunctivitis). optimized expression of virulence required anaerobic growth to log phase in particular media such as brain heart infusion broth. kinetic studies of guinea pig eye infections showed that as few as 2 x 10(5) s. dysenteriae cg097 or s. flexneri m90t, grown under these optimized conditions, produced keratoconjunctiv ... | 1991 | 1778444 |
| damage to hepatic thyroxine 5'-deiodination induced by pathogenic factors of keshan disease and the preventive effects of selenium and vitamin e. | experiments were performed to investigate the change of hepatic t4 5'-deiodination and the preventive effects of selenium (se) and vitamin e in rats fed grains from a keshan disease (kd) endemic area. the results showed that consumption of the endemic grain for 8 weeks caused a significant reduction in hepatic t4 5'-monodeiodinase and glutathione peroxidase activities, and a marked enhancement of hepatic malondialdehyde content. these changes could be effectively prevented through se or vitamin ... | 1991 | 1781930 |
| effect of warfarin on early rat tooth development. | rat pups were treated from birth to 5 days of age with the vitamin k antagonist warfarin in order to investigate possible functions of the vitamin k-dependent dentin gla protein (dgp) in tooth development. warfarin completely eliminated the immunocytochemically detectable dgp which is a prominent feature of dentin in control rat pups, and also caused an increased concentration of dgp in odontoblasts. warfarin treatment did not affect the ultrastructure of cells or the extracellular matrix in the ... | 1991 | 1782575 |
| effects of testosterone on the liver of castrated rats: morphologic study. | it is well known that castration in rats causes atrophy of the sexual organs and, to a lesser extent, of other organs. we have observed that castration causes a reduction of the liver weight due to a reduction (-10%) of the numerical density of the hepatocytes after castration (p less than 0.01). testosterone administration at high concentration (2.5 mg/100 g b. wt.) as well as at low concentration (0.025 mg/100 g) in the castrated rats causes an increase of the liver weight due to an increase ( ... | 1991 | 1783042 |
| [the effect of the synergistic action of enterotoxin on the specific protective complex of shigella sonnei]. | the study has first established that enterotoxin enhances the protective potency of s. sonnei specific protective complex. this effect has been revealed both in experiments of the oral immunization of mice and in experiments of the conjunctival immunization of guinea pigs and depends on the dose of enterotoxin used in the experiment. the increase of protection has a specific character. these observations open prospects for further enhancement for the protective properties of s. sonnei specific p ... | 1991 | 1789032 |
| [the culture of discussions and a little bit on the epidemiology of intestinal infections]. | 1991 | 1789044 | |
| ["the modern theoretical and practical concepts of the epidemiology of shigellosis" and the culture of discussions]. | 1991 | 1789045 | |
| furosemide inhibits the centrally-mediated pressor response to clonidine in conscious, normotensive rats. | 1. the effect of furosemide on the pressor response induced by intracerebroventricular (i.c.v.) injection of clonidine was investigated in freely moving, normotensive rats with chronically implanted arterial catheters. 2. when injected i.c.v., clonidine at doses of 5 and 10 micrograms produced a dose-dependent pressor response and a decrease in heart rate. no depressor response was induced by clonidine. 3. systemic (i.v.) pretreatment with furosemide (2-10 mg kg-1) increased urine volume and dos ... | 1991 | 1797326 |
| furosemide inhibits the centrally-mediated pressor response to clonidine in conscious, normotensive rats. | 1. the effect of furosemide on the pressor response induced by intracerebroventricular (i.c.v.) injection of clonidine was investigated in freely moving, normotensive rats with chronically implanted arterial catheters. 2. when injected i.c.v., clonidine at doses of 5 and 10 micrograms produced a dose-dependent pressor response and a decrease in heart rate. no depressor response was induced by clonidine. 3. systemic (i.v.) pretreatment with furosemide (2-10 mg kg-1) increased urine volume and dos ... | 1991 | 1797326 |
| serotype distribution and antimicrobial resistance of shigella isolates in singapore. | serogrouping of 506 shigella strains isolated in singapore from 1986 to 1990 showed that shigella flexneri (60.3%) was the most common, followed by s. sonnei (33.6%), s. boydii (3.2%) and s. dysenteriae (3%). of the 23 shigella serotypes identified, the predominant ones were s. flexneri types 2a and 1b, s. boydii types 1 and 5, and s. dysenteriae types 1 and 3. more than 80% of the shigella species were resistant to at least one antimicrobial drug, and the incidence of multiresistance was partic ... | 1991 | 1800565 |
| [clinical effect and laboratory observation of ofloxacin in the treatment of typhoid fever, bacillary dysentery and gonorrhea]. | ofloxacin was used in the treatment of 20 cases of typhoid fever, 32 cases of bacillary dysentery and 50 cases of gonococcal infection. altogether 102 cases were treated, 53 being male and 49 female. the daily dosage was 400 mg to 600 mg, divided into two times. the result showed that the clinical effective rate for typhoid fever, bacillary dysentery and gonococcal infections was 100%, 97% and 94% respectively, while the bacterial eradication rate was 100%, 100% and 94% respectively. the bacteri ... | 1991 | 1806341 |
| changing antibiotic sensitivity patterns in shigellosis. | over five and a half months stool cultures were performed in 154 patients admitted with suspected bacillary dysentery to the professorial paediatric unit of the teaching hospital, galle. thirty one patients had a positive stool culture; shigella dysenteriae type 1 was isolated in 23 patients, and s flexneri in 8. in both groups the antibiotic sensitivity pattern was uniform, the only difference being s dysenteriae type 1 being resistant to nalidixic acid while s flexneri was sensitive. this anti ... | 1991 | 1807844 |
| stereoselective disposition of ibuprofen enantiomers in the isolated perfused rat kidney. | the renal clearance of ibuprofen enantiomer was studied separately in the isolated perfused rat kidney at initial perfusate concentrations of 10 micrograms/ml (n = 4) and 100 micrograms/ml (n = 4). perfusate and urine samples were measured for r(-) and s(+)-ibuprofen using a stereospecific hplc assay; urine samples were also analyzed after alkaline hydrolysis. functional viability of the kidney was assured by determining the fractional excretion of glucose and glomerular filtration rate (gfr) at ... | 1991 | 1808617 |
| [cloning and expression of shiga-toxin gene from shigella dysenteriae type i]. | the chromosomal dna of s. dysenteriae type i w30864 was isolated and digested by ecori. the 3-7 kb dna fragments were recovered and ligated with vector puc-19. after transformation, the recombinants were screened by slt gene probe. the positive clones were obtained. the cloned ecori fragment containing both st-a and st-b subunit gene was about 4.5 kb. the cloned st strain was also detected by hela-s3 cell for cytotoxicity, and detected by rabbit ileal loop test for enterotoxicity. besides, the c ... | 1991 | 1814045 |
| thiourea and methionine effects upon glucose and leucine absorption in chicken jejunum. | administration of a unique dose of thiourea (7 mg per kg b.w.) in the 7th day of life to broiler chickens affects in different manners the jejunal absorption of glucose and that of leucine. methionine supplementation of the fodder (1.5 g per kg) during 40 days affects--in an age-dependent manner--the glucose absorption, but not that of leucine. | 1991 | 1817667 |
| thiourea and methionine effects upon glucose and leucine absorption in chicken jejunum. | administration of a unique dose of thiourea (7 mg per kg b.w.) in the 7th day of life to broiler chickens affects in different manners the jejunal absorption of glucose and that of leucine. methionine supplementation of the fodder (1.5 g per kg) during 40 days affects--in an age-dependent manner--the glucose absorption, but not that of leucine. | 1991 | 1817667 |
| expression of virulence and antibiotic resistance in an escherichia coli transconjugant carrying a large plasmid pcat120 of shigella dysenteriae type i and its spontaneous fragmentations. | the role of a 120-kb plasmid in relation to virulence and drug resistance factor in shigella dysenteriae was studied. for characterization of plasmids, the mating system is a useful and efficient means of transferring both large and small plasmids to a new host. the conjugative transfer of a 120-kb (pcat120) ampicillin-resistant plasmid of s. dysenteriae to e. coli k-12 was not successful. introduction of an e. coli fertility factor plasmid f, did not help to mobilize the plasmid. low transfer f ... | 1991 | 1823646 |
| bacterial endotoxins: comparison of mitogenic, polyclonal, antibody-inducing and toxicity activities. | the mitogenic effects on mouse spleen lymphocytes were determined in a large series of commercially available and laboratory-prepared lipopolysaccharides (lps) obtained from escherichia, salmonella, serratia and shigella species; part of these lps preparations was chemically modified prior to testing. in order to establish whether the degree of mitogenic activity corresponds with other biological effects of these preparations, polyclonal activity, capability to induce specific antibody formation ... | 1991 | 1823655 |
| occupational contact dermatitis due to acrylonitrile. | within dsm chemicals bv, a producer of acrylonitrile, skin complaints are frequent. the majority of these are of an irritant nature, while a smaller portion is based on acquired allergies. allergological examination revealed 5 employees with an allergy to acrylonitrile. 1 of these subjects also developed paraesthesiae in the skin sites affected, a finding not previously described for acrylonitrile. in the guinea pig maximization test (gpmt), acrylonitrile showed strong allergenic potential. for ... | 1991 | 1828409 |
| occupational contact dermatitis due to acrylonitrile. | within dsm chemicals bv, a producer of acrylonitrile, skin complaints are frequent. the majority of these are of an irritant nature, while a smaller portion is based on acquired allergies. allergological examination revealed 5 employees with an allergy to acrylonitrile. 1 of these subjects also developed paraesthesiae in the skin sites affected, a finding not previously described for acrylonitrile. in the guinea pig maximization test (gpmt), acrylonitrile showed strong allergenic potential. for ... | 1991 | 1828409 |
| the nature and importance of the inter-epsilon chain disulfide bonds in human ige. | ige antibodies are best known for their pathological role in allergy. the class-specific effector sites are located in the epsilon chains; these form covalent dimers via two cystine residues (cys241 and cys328) linking opposite c epsilon 2 domains. the nature and biological significance of the inter-epsilon chain disulfide-bond arrangement is unresolved. for structural and functional analysis site-specific mutations were introduced into the c epsilon 2 domain of recombinant human ige. the introd ... | 1991 | 1828428 |
| the nature and importance of the inter-epsilon chain disulfide bonds in human ige. | ige antibodies are best known for their pathological role in allergy. the class-specific effector sites are located in the epsilon chains; these form covalent dimers via two cystine residues (cys241 and cys328) linking opposite c epsilon 2 domains. the nature and biological significance of the inter-epsilon chain disulfide-bond arrangement is unresolved. for structural and functional analysis site-specific mutations were introduced into the c epsilon 2 domain of recombinant human ige. the introd ... | 1991 | 1828428 |
| molecular epidemiology of shigella infections: plasmid profiles, serotype correlation, and restriction endonuclease analysis. | plasmid isolation was used to refine the epidemiologic analysis for 168 shigellosis cases in pima county, ariz. plasmids of less than 20 kb were used for comparison of plasmid profiles. plasmid patterns for each species were distinct. a total of 57 of 74 (77%) shigella flexneri strains could be placed into seven plasmid patterns, 70 of 79 (89%) shigella sonnei strains could be placed into seven patterns, 12 shigella boydii strains could be placed into six patterns, and each of 3 shigella dysente ... | 1991 | 1847148 |
| high blood pressure during pregnancy and working conditions among hospital personnel. | the relationship between working conditions and high blood pressure during pregnancy was analysed in a sample of 621 women hospital employees in the paris region over the period 1979-1981. data were collected by interviews during the routine medical visit at the end of postnatal leave. women who had to work standing up for extended periods of time, who had to carry heavy loads or who had to perform heavy cleaning tasks had high blood pressure during their pregnancy more often than women not expo ... | 1991 | 1855606 |
| prospective hospital based study on persistent diarrhoea. | a total of 383 children aged less than 5 years suffering from acute watery diarrhoea or dysentery were studied in hospital to determine the rate of persistent diarrhoea. altogether 335 (87.5%) recovered within 13 days. only in 48 (12.5%) did the diarrhoea continue for 14 days or more, and they were considered as having persistent diarrhoea. children aged between 7 and 18 months had a significantly increased incidence of persistent diarrhoea. children suffering from grade ii-iv malnutrition const ... | 1991 | 1855686 |
| intestinal obstruction during shigellosis: incidence, clinical features, risk factors, and outcome. | to determine the incidence and outcome of intestinal obstruction during shigellosis, the authors assessed 1211 consecutive patients with shigellosis admitted during a 15-month period to a diarrhea treatment center in dhaka, bangladesh. obstruction was identified in 30 (2.5%) patients. ten (33.3%) of these patients died, compared with 97 (8.2%) of the 1181 patients without obstructions (p less than 0.001; rr = 4.1). in a case-control study, patients with obstructions were compared with 30 control ... | 1991 | 1860627 |
| shigellosis. | 1991 | 1861289 | |
| haemolytic uraemic syndrome in children. | of the 4070 children admitted in the department of paediatrics, 830 (24%) presented with diarrhoea. eleven of these had haemolytic ureamic syndrome (hus) characterised by microangiopathic haemolytic anaemia, thrombocytopenia and acute renal failure. only 3 had positive stool cultures (e. coli 2, shigella dysenteriae 1). two children expired while the rest recovered with conservative management and peritoneal dialysis. thus hus should be remembered as a complication of diarrhoea and a cause of ac ... | 1991 | 1861343 |
| human serum stimulates endothelin-1 synthesis more potently than prostacyclin production by cultured vascular endothelial cells. | human serum stimulated the synthesis of a vasoconstrictive peptide, endothelin-1 (et-1), and a vasodilatory prostanoid, prostacyclin (pgi2), by cultured human umbilical vein endothelial cells in a concentration- and time-dependent manner. incubation in 20% concentration of the serum for 24 h stimulated et-1 synthesis almost six-fold while pgi2 production increased two-fold. in addition, a tumor-promoting phorbol ester, phorbol 12-myristate 13-acetate (pma), inhibited the serum-induced et-1 produ ... | 1991 | 1865754 |
| [two biotin-labeled probes of gentamicin resistance genes]. | a 2.0 kb bamhi-hindiii fragment of pdg0103 from australia containing gentamicin 2"-o-adenylytransferase [ant(2")] gene and a 4.9 kb psti-ecori fragment of pby102 were recovered from low-temperature-melting agarose by the slot method. both fragments were labeled with biotin-7-datp by nick translation with a commercial kit. the result of colony and southern hybridization was that: the 2.0 kb probe from australia hybridized with that containing ant(2") from america, while no hybridization occurred ... | 1991 | 1866941 |
| a case of shigellosis caused by shigella dysenteriae type 1 and shigella flexneri type 5b. | shigella dysenteriae type 1 and shigella flexneri type 5b strains were isolated as causative agents of bacterial dysentery in a patient having visited south-east asia. both strains are a rare finding for bulgaria. s. dysenteriae 1 strains have not been isolated since 1962, and there were only single isolates of s. flexneri 5b. the strains were of the same antibiotic resistance patterns. conjugation experiments showed that resistance is determined by transferrable r-plasmids having identical char ... | 1991 | 1880406 |
| simultaneous infection with multiple serotypes of shigellae in a patient. | we isolated three different serotypes of shigella on admission from a patient with dysentery as well as a shigella-like organism and campylobacter jejuni upon follow-up. the patient produced serum antibodies to all three serotypes of shigellae. | 1991 | 1889185 |
| endocytosis and intracellular transport of the glycolipid-binding ligand shiga toxin in polarized mdck cells. | the glycolipid-binding cytotoxin produced by shigella dysenteriae 1, shiga toxin, binds to mdck cells (strain 1) only after treatment with short-chain fatty acids like butyric acid or with the tumor promoter 12-o-tetradecanoylphorbol 13-acetate. the induced binding sites were found to be functional with respect to endocytosis and translocation of toxin to the cytosol. glycolipids that bind shiga toxin appeared at both the apical and the basolateral surface of polarized mdck cells grown on filter ... | 1991 | 1901867 |
| bacteriological and protozoal study on domestic water supply in karachi. | four hundred and fifty eight water samples collected from domestic tanks and taps and community taps were analysed for bacterial contamination. faecal pollution was more in domestic tanks and taps in mehmoodabad, korangi and least in water collected from community taps of liaquatabad, korangi and mehmoodabad. bacteria isolated were mostly e. coli, enterobacter sp, klebsiella sp. and a. faecalis, while other organisms (except pseudomonas) were found in lower numbers. salmonella para typhi and par ... | 1991 | 1902529 |
| differential effects of gonadotrophin-releasing hormone agonists administered as desensitizing or flare protocols on hormonal function in the luteal phase of hyperstimulated cycles. | the incorporation of gonadotrophin-releasing hormone agonist (gnrha) in in-vitro fertilization (ivf) stimulation protocols has led to doubt about the quality of the subsequent luteal phase. the effects of two gnrha stimulation protocols on luteal phase concentrations of oestradiol (e2), progesterone (p), luteinizing hormone (lh) and follicle stimulating hormone (fsh) were compared with the standard clomiphene stimulation regimen. subjects receiving clomiphene with human menopausal gonadotrophin ... | 1991 | 1905309 |
| new trends in the use of al(oh)3-conjugated endotoxins and their subunits from the s- and r-forms of shigella dysenteriae serovar 1 for model vaccination purposes. | the lipopolysaccharides, lipopolysaccharide-protein complexes and their lipids a, isolated from shigella dysenteriae 1, exhibited lethal toxicity (ld50 300-400 micrograms per mouse), pyrogenicity (0.01-1.0 microgram), activity in the limulus test (10(-3)-10(-12) mg ml-1) and produced a positive local shwartzman reaction. it was found that these substances bound to al(oh)3 were capable of successfully protecting mice from challenge with both homologous and heterologous infections (up to 90% of mi ... | 1991 | 1905447 |
| antimicrobial activity of microgard against food spoilage and pathogenic microorganisms. | microgard, a commercially available fermented milk product containing antimicrobial metabolites, was a potent inhibitor for gram-negative bacteria such as pseudomonas, salmonella, and yersinia when 1% concentration was incorporated into agar media. gram-positive bacillus cereus, staphylococcus aureus, and listeria monocytogenes were insensitive to microgard. kluyveromyces marxianus, an unidentified black yeast, and penicillium expansum were partially suppressed, whereas aspergillus niger and a y ... | 1991 | 1906486 |
| screening of children for enteric bacterial pathogens in the outborn neonatal ward in lagos, nigeria. | babies, on admission into a neonatal ward at the lagos university teaching hospital, had their rectal swab specimens examined bacteriologically and screened for enteric bacterial pathogens over a one-year-period at two-week intervals. it was found that on the average there were 3 (9.68%) enteric bacterial pathogens out of an average of 31 admissions at each screening period. the enteric bacterial pathogens isolated included: non-typhoid salmonellae, which accounted for 55 (80.88%) isolates out o ... | 1991 | 1915794 |
| reemergence of shigella dysenteriae type 2 in sicily: an epidemiological evaluation. | three strains of shigella dysenteriae type 2 were isolated from a small household outbreak which occurred in palermo, sicily, during summer 1990. two isolates were recovered from hospitalized patients and one from an asymptomatic carrier. the infection could not be associated with travel to foreign countries or contact with travellers returned from abroad. since 1953 s. dysenteriae has been never isolated in southern italy. the isolates from dysentery cases were susceptible to antibiotics and ca ... | 1991 | 1921742 |
| shigellosis. shigella dysenteriae type 1. | 1991 | 1931580 | |
| preparation, characterization, and immunogenicity of conjugates composed of the o-specific polysaccharide of shigella dysenteriae type 1 (shiga's bacillus) bound to tetanus toxoid. | the background for developing conjugate vaccines for shigellosis composed of the o-specific polysaccharide (o-sp) bound to a protein is described elsewhere (c. y. chu, r. schneerson, and j. b. robbins, submitted for publication). briefly, there is direct evidence for type (lipopolysaccharide [lps])-specific protection after infection with the wild type or with attenuated strains of shigellae. prospective studies of israeli armed forces recruits show a correlation between preexisting serum immuno ... | 1991 | 1937803 |
| compartmentalization within the nucleus: discovery of a novel subnuclear region. | antibodies to a set of structurally related autoantigens (p23-25) bind to a previously uncharacterized, large structural domain in the nucleus of a variety of human cell types. this subnuclear domain is visible by phase contrast alone as a region of decreased density after several different fixation protocols. the morphology of this region changes dramatically during the cell cycle and we have given it the name pika (for polymorphic interphase karyosomal association) based on preliminary evidenc ... | 1991 | 1955462 |
| evaluation of the role of shiga and shiga-like toxins in mediating direct damage to human vascular endothelial cells. | infection with shiga toxin- and shiga-like toxin-producing strains of shigella dysenteriae and escherichia coli, respectively, can progress to the hemolytic-uremic syndrome. it has been hypothesized that circulating shiga toxin, shiga-like toxins, and endotoxins may contribute to the disease by directly damaging glomerular endothelial cells. the effects of these toxins on hela, vero, and human vascular endothelial cells (ec) were examined. confluent ec were sensitive to shiga toxin but were at l ... | 1991 | 1649877 |
| molecular typing of shigella strains using pulsed field gel electrophoresis and genome hybridization with insertion sequences. | the genomes of 18 independent shigella isolates (9 shigella sonnei, 5 shigella dysenteriae and 4 shigella flexneri) as well as of 4 epidemic s. flexneri strains were analysed by pulsed field gel electrophoresis (pfge) and by the distribution of insertion sequences (is1, is2 and is911). despite the close relatedness observed among the 9 independent s. sonnei, all of them could be differentiated from each other. the 4 independent s. flexneri isolates showed clearly distinguishable dna profiles. ne ... | 1991 | 1658885 |
| programmed translational frameshifting and initiation at an auu codon in gene expression of bacterial insertion sequence is911. | the proteins expressed by insertion sequence is911, a member of the widespread is3 family of elements, have been analyzed. the results indicate that three major species are produced from two consecutive reading frames. a protein of mr 11,500, orfa, is synthesized from an upstream reading frame. a larger protein, orfab, uses the same initiation codon and is produced by a -1 programmed translational frameshift between orfa and a downstream frame, orfb, whose amino acid sequence shows significant h ... | 1991 | 1660923 |
| gene transfer in enteric bacteria through the formation of r-prime plasmids by an rp4: :mini-mu element. | gene transfer in seven pathogenic enteric bacteria was studied using an rp4: :mini-mu element, the plasmid pulb113. from the e. coli k-12 host strain the plasmid could be efficiently transferred to these enteric bacteria, but its transfer back to e. coli k-12 was not as efficient, being detected only in shigella dysenteriae 1, s. flexneri and the 'smooth' variant of s. sonnei. in these three species, transposition of chromosomal fragments into the plasmid to produce r-prime plasmid was also dete ... | 1991 | 1661362 |
| improved method for measurement of rhodanese activity using methanethiosulfonate as sulfur donor substrate and its application to human serum. | we have developed a sensitive method for the measurement of rhodanese activity in human serum which is based on the colorimetric method for the determination of thiocyanate produced from methanethiosulfonate and cyanide as substrates. thiocyanate gives a red complex with ferric ion in an acidic condition. the present method is about 70-fold more sensitive than the conventional method using cyanide and thiosulfate as substrates and correlates well (r = 0.997) with the conventional method in bovin ... | 1991 | 1667623 |
| effect of diabetes mellitus on epididymal enzymes of adult rats. | diabetes mellitus caused significant reduction in serum testosterone and accessory sex glands weight. the sperm content of epididymal regions also decreased. among the epididymal regions, the cauda epididymidal tissue alone showed significant reduction in na(+)-k+ atpase activity. however, mg2+ atpase activity was lowered in caput epididymidis only. specific activity of ca2+ atpase significantly decreased in caput and cauda epididymides. all three atpases decreased significantly in caput epididy ... | 1991 | 1667646 |
| molecular epidemiologic techniques in analysis of epidemic and endemic shigella dysenteriae type 1 strains. | during 1988 the number of shigella dysenteriae type 1 infections reported in the united states increased fivefold. to determine if recent isolates from mexico were related to those that caused epidemics of dysentery worldwide, southern hybridization analysis was done with shiga toxin and ribosomal rna gene probes. western hemisphere and eastern hemisphere strains differed by the size of a single ecori fragment carrying the shiga toxin genes. three ribosomal dna (rdna) patterns were observed, whi ... | 1991 | 1671055 |
| identification of three amino acid residues in the b subunit of shiga toxin and shiga-like toxin type ii that are essential for holotoxin activity. | shiga toxin of shigella dysenteriae type i and shiga-like toxins i and ii (slt-i and slt-ii, respectively) of enterohemorrhagic escherichia coli are functionally similar protein cytotoxins. these toxin molecules have a bipartite molecular structure which consists of an enzymatically active a subunit that inhibits protein synthesis in eukaryotic cells and an oligomeric b subunit that binds to globotriaosylceramide glycolipid receptors on eukaryotic cells. regionally directed chemical mutagenesis ... | 1991 | 1991714 |
| production and characterization of a monoclonal antibody specific for enterohemorrhagic escherichia coli of serotypes o157:h7 and o26:h11. | a monoclonal antibody (mab 4e8c12) specific for escherichia coli o157:h7 and o26:h11 was produced by immunizing balb/c mice with a rough strain of e. coli o157:h7. the antibody reacted strongly by a direct enzyme-linked immunosorbent assay with each of 36 strains of e. coli o157:h7. no cross-reactivity was observed with strains of salmonella spp., yersinia enterocolitica, shigella dysenteriae, proteus spp., escherichia hermanii, klebsiella pneumoniae, campylobacter jejuni, serratia marcescens, c ... | 1991 | 1993773 |
| synthetic peptides as the basis for vaccine design. | 1991 | 2017193 | |
| unusual association of a plasmid with nalidixic acid resistance in an epidemic strain of shigella dysenteriae type 1 from asia. | the association of a 20-mda plasmid with nalidixic acid resistant (nalr) strains of shigella dysenteriae 1 has been examined. the plasmid, which is readily transferable, does not itself code for nalidixic acid resistance but offers a survival advantage to its host under nalidixic acid stress. the plasmid-containing cultures of s. dynsenteriae 1 produced nalr mutants in vitro at a frequency 1000-fold higher than their plasmidless parent strains, after two exposures to nalidixic acid. using a simi ... | 1991 | 2021898 |
| efficacy of aqueous extract of garlic & allicin in experimental shigellosis in rabbits. | the aqueous extract of garlic (allium sativum) and allicin both showed significant in vitro antibacterial activity against isolates of multiple drug-resistant shigella dysenteriae 1, sh. flexneri y, sh. sonnei and enterotoxigenic escherichia coli. the minimum inhibitory concentrations of the aqueous extract and allicin against sh. flexneri y were 5 and 0.4 microliters/ml, respectively. the two agents also showed promising in vivo antibacterial activity against sh. flexneri y when tested in the r ... | 1991 | 2022399 |
| the association of haemagglutination and adhesion with lipopolysaccharide of shigella dysenteriae serotype 1. | in this study the ability of strains of shigella dysenteriae serotype 1 to agglutinate mammalian erythrocytes is attributed to the polysaccharide fraction of bacterial-cell lipopolysaccharide (lps). lps obtained from a rough, mutant strain of s. dysenteriae serotype 1, lacking the o-antigen polysaccharide side-chain, did not agglutinate erythrocytes, clearly demonstrating a link between o-antigen polysaccharides and haemagglutinating activity (ha). strains of s. dysenteriae serotype 1 adhered we ... | 1991 | 2030501 |
| conversion of oral glucose to lactate in dogs. primary site and relative contribution to blood lactate. | we evaluated the relative contribution of oral glucose to arterial lactate and the relative role of the splanchnic bed in converting glucose to lactate in normal healthy dogs. after an oral glucose load (1.2 g/kg) spiked with [u-14c]glucose (16.9 muci/kg; protocol 1, n = 7), arterial blood lactate increased from 0.43 +/- 0.03 mm at basal to a peak of 1.04 +/- 0.07 mm at 45 min and then slowly decreased to 0.47 +/- 0.07 mm at 240 min. arterial blood [14c]lactate peaked at 60 min and then decrease ... | 1991 | 2040389 |
| four decades of shigellosis in israel: epidemiology of a growing public health problem. | despite the improved standard of living in israel, shigellosis remains a common disease. examination of trends in the incidence of shigellosis in israel between 1951 and 1987 showed a period of declining rates followed by an increase in the reported incidence beginning around 1969. this increase was mainly due to shigella sonnei; rates of infection with shigella flexneri remained relatively constant. trends showed marked differences between age groups and between ethnic groups. in comparison, th ... | 1991 | 2041956 |
| shigella dysenteriae type 1--guatemala, 1991. | on march 14, 1991, physicians at a hospital in guatemala city reported to the institute of nutrition of central america and panama (incap) that a 2-year-old boy living in an orphanage in guatemala city had been hospitalized with dysentery; stool cultures yielded shigella dysenteriae type 1. another child from the orphanage had recently died from dysentery. during march 18-21, two other young children from the orphanage were diagnosed with s. dysenteriae type 1. on march 21, health officials in r ... | 1991 | 2046650 |
| epidemiologic aspects of shigellosis and other causes of dysentery in thailand. | nearly 20% of children seen in the outpatient department of children's hospital in bangkok, thailand, for diarrheal disease had bloody diarrhea. shigella species and enteroinvasive escherichia coli--isolated from 13% and 2% of children with diarrhea, respectively--were the most frequent causes of bloody diarrhea. campylobacter species and nontyphoidal salmonella species were also isolated frequently but were much less often associated with bloody diarrhea. shigella species were rarely isolated f ... | 1991 | 2047642 |
| shigellosis in vietnam: seroepidemiologic studies with use of lipopolysaccharide antigens in enzyme immunoassays. | the performance of enzyme immunoassays (eias) with use of o-antigen-containing lipopolysaccharides (lpss) extracted with phenol-water from shigella dysenteriae type 1, shigella flexneri serotypes 1a-5b, and shigella sonnei for determination of the serum antibody responses after onset of bacillary dysentery is reviewed. for the purpose of several studies, serum samples from a total of 175 vietnamese and 47 swedish patients, for whom shigella species had been isolated from fecal specimens, were ob ... | 1991 | 2047643 |
| mortality due to shigellosis: community and hospital data. | almost all fatal cases of shigellosis occur in developing countries, and data on mortality are generally compiled from three sources: investigations of epidemics caused by shigella dysenteriae type 1, surveillance of endemic diarrheal disease, and reports from hospitals. attack rates during epidemics of dysentery due to infection with s. dysenteriae type 1 have ranged from 1% to 33%, and case-fatality rates have ranged from 1% to 7%. in matlab, a rural district in bangladesh, most diarrhea-relat ... | 1991 | 2047645 |
| shiga toxin: purification, structure, and function. | shiga toxin is a potent toxin produced by shigella dysenteriae type 1 strains. the toxin has three biologic activities--cytotoxicity, enterotoxicity, and neurotoxicity--and one known biochemical effect: inhibition of protein synthesis. it consists of two polypeptide chains, an a chain (molecular weight, 32,225) and a b chain (molecular weight, 7,691). these two peptides associate with a stoichiometry of one a and five b subunits to form the holotoxin. the a chain is responsible for the biochemic ... | 1991 | 2047652 |
| digalactosyl-containing glycolipids as cell surface receptors for shiga toxin of shigella dysenteriae 1 and related cytotoxins of escherichia coli. | purified glycolipids containing galactose-alpha(1-4)galactose bind with shiga toxin of shigella dysenteriae 1 and shiga-like toxins of escherichia coli with high specificity in both thin-layer chromatograms and glycolipid-coated microtiter plates. these glycolipids appear to be the natural cell surface receptors for this class of bacterial toxins since artificial glycoconjugates block cytotoxicity as well as binding of 125i-labeled toxin. cell lines lacking these glycolipids are refractory to to ... | 1991 | 2047653 |
| shiga toxin: intestinal cell receptors and pathophysiology of enterotoxic effects. | shiga toxin is enterotoxic in rabbit small bowel and binds to the microvillus membrane (mvm). the toxin exhibits specificity for glycolipids possessing a terminal gal-alpha 1----4gal disaccharide, including the neutral glycolipid gb3 in mvm. gb3, which is developmentally regulated in the rabbit small bowel, is present in very low concentration until the animals reach day 16 of life. in older animals an increase in gb3 content is paralleled by an increase in the ability of mvm to bind toxin, whic ... | 1991 | 2047654 |
| intestinal manifestations of invasive diarrheas and their diagnosis. | data from studies of 916 children with diarrhea, including 122 from whom shigellae were isolated, and data on patients affected in an epidemic due to shigella dysenteriae type i were analyzed to determine whether a diagnostic clinical profile of shigellosis could be identified. blood and/or mucus in stool, increased frequency of stool, abdominal pain, rectal tenesmus, and fever were noted more frequently in patients with shigellosis. the diagnostic confirmation of shigellosis depends on the isol ... | 1991 | 2047655 |
| antimicrobial therapy for shigellosis. | in controlled clinical trials, which were first performed with use of the sulfonamides, antimicrobial agents have been shown to shorten the duration of symptoms and lessen the excretion of pathogens during episodes of shigellosis. not all antimicrobial agents that are active in vitro against shigella are effective in vivo, and efficacy of an agent can only be assessed by properly conducted clinical trials. resistance to both ampicillin and trimethoprim-sulfamethoxazole, the drugs of choice for t ... | 1991 | 2047659 |
| site-specific recombinase genes in three shigella subgroups and nucleotide sequences of a pinb gene and an invertible b segment from shigella boydii. | inversional switching systems in procaryotes are composed of an invertible dna segment and a site-specific recombinase gene adjacent to or contained in the segment. four related but functionally distinct systems have previously been characterized in detail: the salmonella typhimurium h segment-hin gene (h-hin), phage mu g-gin, phage p1 c-cin, and escherichia coli e14 p-pin. in this article we report the isolation and characterization of three new recombinase genes: pinb, pind, and defective pinf ... | 1991 | 2061288 |
| [a provisional serovar of shigella dysenteriae isolated in japan from travellers' diarrhea]. | a bacterial strain was isolated that possessed the biochemical characteristics of shigella dysenteriae but did not belong to any of the established s. dysenteriae serovars, from the feces of a diarrheal case who had travelled to turkey, pakistan, india and thailand for about a month. this strain was invasive to tissue culture cells and gave a positive serény test. preparing antiserum against this strain and examining the antigenic relationship with the established o antigens of shigella and esch ... | 1991 | 2066600 |
| total reflection in tooth substance and diagnosis of cracks in teeth. a clinical study. | 1991 | 270234 | |
| [plasmatic ampc and gmpc changes in asthmatic patients induced by beta stimulation or blockade and methylcholine (author's transl)]. | 1991 | 208056 | |
| metastatic tumors of the endocardium: report of three cases. | because of their apparent rarity and the tendency of clinicians to lump indicative signs and symptoms under the heading of metastatic disease, metastatic tumors of the endocardium are seldom mentioned in the literature, in the three cases presented herein, endocardial metastases were evident at autopsy. in one case of malignant melanoma, clinical evidence for endocardial involvement was present in life. this article also presents a case of endocardial involvement by wilms' tumor and a case of en ... | 1991 | 207236 |
| a new microsurgical needleholder. | microsurgery demands precise and rapid manipulation of needle and thread with maintenance of special respect for the fragility of the tissues. the design of the needleholder is of paramount importance in achieving these goals. the instrument described below is light, long enough to rest comfortably in the hand, and balanced in such a way that it can be manipulated into awkward corners with relative ease. | 1991 | 269711 |
| [effect of anaprilin on the clinical course of stenocardia and the carbohydrate metabolic indices of ischemic heart disease patients in relation to the nature of their glucose tolerance]. | fourteen-day anaprilin treatment of coronary patients with varying glucose tolerance has demonstrated that the drug's therapeutic efficiency was greater in patients with normal glucose tolerance. anaprilin caused a moderate drop in baseline glucose level and considerably limited the degree of hyperglycemia in response to the glucose tolerance test in coronary patients with abnormally low glucose tolerance. insulin content was virtually unaffected by the drug, irrespective of the type of glucose ... | 1991 | 3327995 |
| [supernumerary teeth in the deciduous dentition]. | the authors presented sovrannumeraries (s) teeth in primary dentition, and the pedodontic, surgical and orthodontic problems. semeiotics signs, and x ray suggested, are described. all the types of s. teeth are showed: supplementaries, conoides, tuberculates and infundibuliformes. for every type characteristics, problems and surgical timing are described. tuberculates and infundibuliformes teeth are the most dangerous for the permanent teeth interrupted: eruption delay, dilacerations, impactions, ... | 1991 | 2288972 |
| amputation: surgical technique and postoperative management. | the decision to amputate should be made with due consideration of the eventual rehabilitation of the patient. with this in mind, general principles of amputation surgery are outlined and specific levels of amputation are described. early post-amputation management has advanced over the last two decades to make rehabilitation goals the more readily reached. these advances are discussed. | 1991 | 269712 |
| haematological investigation in neonates. | 1990 | 2271791 | |
| effect of the canadian air force training programme on a submaximal exercise test. | validation of the submaximal heart rate/oxygen consumption relationship as an index of 'cardiorespiratory fitness' requires the demonstration of systematic alterations in this relationship concomitant with interventions designed to alter physical fitness. to fulfil those criteria a longitudinal training/de-training study was undertaken. previously sedentary adult subjects undertook the canadian airforce 5bx-xbx exercise programme. submaximal exercise tests were performed before and after trainin ... | 1990 | 258828 |