Publications

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metal-responsive promoter dna compaction by the ferric uptake regulator.short-range dna looping has been proposed to affect promoter activity in many bacterial species and operator configurations, but only few examples have been experimentally investigated in molecular detail. here we present evidence for a metal-responsive dna condensation mechanism controlled by the helicobacter pylori ferric uptake regulator (fur), an orthologue of the widespread fur family of prokaryotic metal-dependent regulators. h. pylori fur represses the transcription of the essential arsrs ...201627558202
p53, a potential predictor of helicobacter pylori infection-associated gastric carcinogenesis?helicobacter pylori (h. pylori) is an ancient and persistent inhabitant of the human stomach that is closely linked to the development of gastric cancer (gc). . emerging evidence suggests that h. pylori strain interactions with gastric epithelial cells subvert the best- characterized p53 tumour suppressor pathway. a high prevalence of p53 mutations is related to h. pylori infection. h. pylori also accelerates p53 protein degradation by disturbing the mdm2-p53 feedback loop. additionally, h. pylo ...201627556187
linked color imaging improves endoscopic diagnosis of active helicobacter pylori infection.linked color imaging (lci) is a new image-enhanced endoscopy technique using a laser light source to enhance slight differences in mucosal color. the aim of this study was to compare the usefulness of lci and conventional white light imaging (wli) endoscopy for diagnosing helicobacter pylori (h. pylori).201627556101
therapeutic or spontaneous helicobacter pylori eradication can obscure magnifying narrow-band imaging of gastric tumors.we previously reported that narrow-band imaging with magnifying endoscopy (nbi-me) revealed a unique "gastritis-like" appearance in approximately 40 % of early gastric cancers after helicobacter pylori eradication. because rates of gastric cancer are increasing in patients with non-persistent infection of h. pylori, we aimed to clarify contribution factors to obscure tumors after therapeutic or spontaneous eradication.201627556076
rare case of primary gastric burkitt lymphoma in a child.primary gastric tumors are very rare in children. burkitt lymphoma is a common type of non-hodgkin's lymphoma, and gastric burkitt lymphoma usually occurs in the aged. when involving the gastrointestinal tract, primary gastric burkitt lymphoma is very rare in younger childhood. many gastric lymphomas including mucosa-associated lymphoid tissue lymphoma are associated with helicobacter pylori infection or acute bleeding symptom. we report a seven-year-old boy who presented with only some vomiting ...201627554215
[optimal operational definition of patient with peptic ulcer bleeding for big data analysis using combination of clinical characteristics in a secondary general hospital].peptic ulcer bleeding (pub) is the most common cause of upper gastrointestinal bleeding in korea but there has been no research done using big data. this study evaluates the optimal operational definition (od) for big data research by analyzing clinical characteristics of pub.201627554214
inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer.gastric cancer (gc) is the fifth most common malignancy in the world. the major cause of gc is chronic infection with helicobacter pylori (h. pylori). infection with h. pylori leads to an active inflammatory microenvironment that is maintained by immune cells such as t cells, macrophages, natural killer cells, among other cells. immune cell dysfunction allows the initiation and accumulation of mutations in gc cells, inducing aberrant proliferation and protection from apoptosis. meanwhile, immune ...201627547005
the role of the microbiome in gastrointestinal cancer.humans are host to complex microbial communities previously termed normal flora and largely overlooked. however, resident microbes contribute to both health and disease. investigators are beginning to define microbes that contribute to the development of gastrointestinal malignancies and the mechanisms by which this occurs. resident microbes can induce inflammation, leading to cell proliferation and altered stem cell dynamics, which can lead to alterations in dna integrity and immune regulation ...201627546848
current perspectives on gastric cancer.gastric cancer (gc) is third leading cause of cancer-related death. only 28.3% of new gc cases survive more than 5 years. although incidence has declined in the united states, an increase is estimated for 2016. risk factors include sex (risk is higher in men), helicobacter pylori infection, heredity, and lifestyle. gc is usually diagnosed between the ages of 60-80 years. prognosis of gc is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse ...201627546840
[efficacy and safety of boceprevir based triple therapy in hungarian patients with hepatitis c genotype 1 infection, advanced stage fibrosis and prior treatment failure].during 2011 and 2013, 155 hungarian hepatitis c genotype 1 infected patients, mostly with advanced liver fibrosis, who did not respond to prior peginterferon + ribavirin dual therapy, started boceprevir based triple therapy in an early access program.201627546804
helicobacter pylori infection and iron deficiency in patients with coronary artery disease.the aim of this study was to investigate whether impact of the seropositivity to helicobacter pylori (h pylori) infection on ferritin and iron levels is an independent risk factor for atherosclerosis in patients with cardiovascular disease. the anti h pylori igg, iga levels, serum ferritin and iron concentration of 86 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by elisa assay. the results of present study showed that ...201627545208
helicobacter pylori cagi is associated with the stability of caga.the type ⅳ secretion system (t4ss) of h. pylori encoded by cag pathogenicity island mediates the injection of the toxin caga, which is considered as a paradigm for bacterial carcinogenesis. t4ss is generally composed of a set of proteins, the majority of which still remain unclear. in this study, we have identified cagi, one of the t4ss proteins, which interacted with caga and played an important role for caga stability.201627544325
evaluation of clarithromycin resistance among iranian helicobacter pylori isolates by e-test and real-time polymerase chain reaction methods.helicobacter pylori is an important pathogen of human gastric mucosa. antibiotic resistance, especially resistance to clarithromycin is a major factor for treatment failure of h. pylori infections. the main mechanism of clarithromycin resistance in these bacteria is related to point mutations in three different locations of 23s rrna gene.201627540451
development and diagnostic evaluation of loop-mediated isothermal amplification using a new gene target for rapid detection of helicobacter pylori.helicobacter pylori cause chronic gastritis and subsequent diseases like gastric and duodenal ulcers and gastric adenocarcinoma. current methods for detecting h. pylori have several disadvantages and it is of utmost importance to develop a simple, quick, accurate, and cost-effective diagnostic test.201627540449
in vitro effect of clarithromycin and alginate lyase against helicobacter pylori biofilm.it is now established that the gastric pathogen helicobacter pylori has the ability to form biofilms in vitro as well as on the human gastric mucosa. the aim of this study is to evaluate the antimicrobial effects of clarithromycin on h. pylori biofilm and to enhance the effects of this antibiotic by combining it with alginate lyase, an enzyme degrading the polysaccharides present in the extracellular polymeric matrix forming the biofilm. we evaluated the clarithromycin minimum inhibition concent ...201627535356
vonoprazan versus conventional proton pump inhibitor-based triple therapy as first-line treatment against helicobacter pylori: a multicenter retrospective study in clinical practice.vonoprazan is a potassium-competitive acid blocker, a new type of acid-suppressing drug, and has recently become available for peptic ulcers, gastroesophageal reflux disease, and helicobacter pylori (h. pylori) eradication. its efficacy for h. pylori eradication has been reported. however, the evidence for its efficacy and feasibility remains limited. we aimed to compare the feasibility, effectiveness and safety of vonoprazan-based triple therapy with conventional proton pump inhibitor (ppi)-bas ...201627534444
stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for helicobacter pylori and mycobacterium tuberculosis in bamako, mali.detection of bacterial urease activity has been utilized successfully to diagnose helicobacter pylori (h. pylori). while mycobacterium tuberculosis (m. tuberculosis) also possesses an active urease, it is unknown whether detection of mycobacterial urease activity by oral urease breath test (ubt) can be exploited as a rapid point of care biomarker for tuberculosis (tb) in humans. we enrolled 34 individuals newly diagnosed with pulmonary tb and 46 healthy subjects in bamako, mali and performed ora ...201627532494
hydrogen metabolism in helicobacter pylori plays a role in gastric carcinogenesis through facilitating caga translocation.a known virulence factor of helicobacter pylori that augments gastric cancer risk is the caga cytotoxin. a carcinogenic derivative strain, 7.13, that has a greater ability to translocate caga exhibits much higher hydrogenase activity than its parent noncarcinogenic strain, b128. a δhyd mutant strain with deletion of hydrogenase genes was ineffective in caga translocation into human gastric epithelial ags cells, while no significant attenuation of cell adhesion was observed. the quinone reductase ...201627531909
other helicobacters and gastric microbiota.this article aimed to review the literature from 2015 dealing with gastric and enterohepatic non-helicobacter pylori helicobacter species (nhph). a summary of the gastric microbiota interactions with h. pylori is also presented. an extensive number of studies were published during the last year and have led to a better understanding of the pathogenesis of infections with nhph. these infections are increasingly reported in human patients, including infections with h. cinaedi, mainly characterized ...201627531542
treatment of helicobacter pylori infection 2016.many interesting articles have been published from different parts of the world over the last year assessing various issues around helicobacter pylori eradication therapy. this article will address the published literature over the last year pertaining to the topic of treatment of h. pylori infection. the main themes that emerge are assessing the efficacy of standard triple therapy, as well as exploring new first-line treatments, mainly optimized nonbismuth-containing and bismuth-containing quad ...201627531541
helicobacter pylori in children.helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. in high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. other controversial issues are related to the ques ...201627531540
helicobacter pylori and extragastric diseases.during the past year, many articles were published on the extragastric diseases related to helicobacter pylori infection. this supports the theory that some microorganisms may cause diseases even far from the primary site of infection by interfering with different biologic processes. the role of h. pylori on idiopathic thrombocytopenic purpura, sideropenica anemia, and vitamin b12 deficiency is well known. on the other hand, there is a growing interest in the bacterium's association with cardiov ...201627531539
gastric cancer pathogenesis.gastric cancer (gc) results from a multistep process that is influenced by helicobacter pylori infection, genetic susceptibility of the host, as well as of other environmental factors. gc results from the accumulation of numerous genetic and epigenetic alterations in oncogenes and tumor suppressor genes, leading to dysregulation of multiple signaling pathways, which disrupt the cell cycle and the balance between cell proliferation and cell death. for this special issue, we have selected to revie ...201627531537
helicobacter pylori and non-malignant upper gastrointestinal diseases.peptic ulcer disease (pud) has been further decreased over the last decades along with decreasing prevalence of helicobacter pylori-associated pud. a delayed h. pylori eradication has been associated with an increased risk of rehospitalization for complicated recurrent peptic ulcer and reemphasized the importance of eradication especially in patients with peptic ulcer bleeding (pub). pub associated with nsaid/aspirin intake and h. pylori revealed an additive interaction in gastric pathophysiolog ...201627531536
inflammation, immunity, and vaccines for helicobacter pylori infection.the tight control of the innate and adaptive immune responses in the stomach mucosa during chronic helicobacter pylori infection is of prime importance for the bacteria to persist and for the host to prevent inflammation-driven diseases. this review summarizes recent data on the roles of innate and adaptive immune responses during h. pylori/host interactions. in addition, the latest preclinical developments of h. pylori vaccines are discussed with a special focus on the clinical trial reported b ...201627531535
pathogenesis of helicobacter pylori infection.helicobacter pylori is estimated to infect more than half of the worlds human population and represents a major risk factor for chronic gastritis, peptic ulcer disease, malt lymphoma, and gastric adenocarcinoma. h. pylori infection and clinical consequences are controlled by highly complex interactions between the host, colonizing bacteria, and environmental parameters. important bacterial determinants linked with gastric disease development include the cag pathogenicity island encoding a type i ...201627531534
recent "omics" advances in helicobacter pylori.the development of high-throughput whole genome sequencing (wgs) technologies is changing the face of microbiology, facilitating the comparison of large numbers of genomes from different lineages of a same organism. our aim was to review the main advances on helicobacter pylori "omics" and to understand how this is improving our knowledge of the biology, diversity and pathogenesis of h. pylori. since the first h. pylori isolate was sequenced in 1997, 510 genomes have been deposited in the ncbi a ...201627531533
diagnostic of helicobacter pylori infection.there is progress in endoscopy techniques. while it is not yet possible to detect helicobacter pylori directly in the stomach, it becomes easier to detect the mucosal changes induced by the bacteria. some small changes can also increase the sensitivity of the invasive tests, for example culture or histology, but the wide use of proton-pump inhibitors has a negative impact on these tests. only molecular methods are able to detect a limited load of bacteria, especially by using real-time pcr but a ...201627531532
epidemiology of helicobacter pylori infection.this review of recent publications related to the epidemiology of helicobacter pylori highlights the origin of the infection, its changing prevalence, transmission, and outcome. a number of studies have addressed the ancestor roots of the bacteria, and the first genomewide analysis of bacterial strains suggests that its coexistence with humans is more ancient than previously thought. as opposed to the generally declining prevalence of h. pylori (including china and japan), in sweden, the prevale ...201627531531
effect of helicobacter pylori infection on growth trajectories in young ethiopian children: a longitudinal study.helicobacter pylori infection has been associated with early childhood growth impairment in high- and middle-income countries; however, few studies have examined this relationship within low-income countries or have used a longitudinal design. the possible effects of h. pylori infection on growth trajectories were examined in a cohort of young ethiopian children.201627531186
low prevalence of clarithromycin-resistant helicobacter pylori isolates with a2143g point mutation in the 23s rrna gene in north india.resistance of helicobacter pylori to clarithromycin is associated with a single base substitution in the 23s rrna gene. in this study, clarithromycin-resistant h. pylori isolates were analysed for the presence of 23s rrna gene mutations. h. pylori were isolated from 68 patients suffering from various gastroduodenal diseases in north india. minimum inhibitory concentrations (mics) were determined by the agar dilution method, and point mutations in clarithromycin-resistant strains were identified ...201627530837
suppressed helicobacter pylori-associated gastric tumorigenesis in fat-1 transgenic mice producing endogenous ω-3 polyunsaturated fatty acids.dietary approaches to preventing helicobacter pylori (h. pylori)-associated gastric carcinogenesis are widely accepted because surrounding break-up mechanisms are mandatory for cancer prevention, however, eradication alone has been proven to be insufficient. among these dietary interventions, omega-3-polyunsaturated-fatty acids (ω-3 pufas) are often the first candidate selected. however, there was no trial of fatty acids in preventing h. pylori-associated carcinogenesis and inconclusive results ...201627528223
helicobacter pylori caga and il-1β promote the epithelial-to-mesenchymal transition in a nontransformed epithelial cell model.gastric cancer is the third cause of cancer death worldwide and infection by helicobacter pylori (h. pylori) is considered the most important risk factor, mainly by the activity of its virulence factor caga. h. pylori/caga-induced chronic inflammation triggers a series of gastric lesions of increased severity, starting with gastritis and ending with cancer. il-1β has been associated with tumor development and invasiveness in different types of cancer, including gastric cancer. currently, it is n ...201627525003
first-line helicobacter pylori eradication among patients with chronic liver diseases in taiwan.helicobacter pylori eradication in patients with chronic liver diseases (clds) and liver cirrhosis is seldom reported. this study aimed to assess the efficacy of 7-day standard triple therapy in patients with cld including cirrhosis and to investigate the clinical factors influencing the success of eradication. a total of 592 h. pylori-infected patients, who received 7-day standard first-line triple therapy between january 1, 2014, and december 31, 2014, were recruited. patients were divided int ...201627523452
[prospects for clinical application of statins in gastroenterology].we present the analytical review of non-cardial effects of statins used in gastroenterology with the data illustrating their high antibacterial activity as exemplified by combined therapy of conditions associated with helicobacter pylori infection. special emphasis is laid on anti-inflammatory and oncoprotective mechanisms of statin action that are successfully made use of for the treatment of liver, pancreas, gallbladder, and biliary system diseases. prophylactic aspects of statin application t ...201627522720
highly accurate prediction of protein-protein interactions via incorporating evolutionary information and physicochemical characteristics.protein-protein interactions (ppis) occur at almost all levels of cell functions and play crucial roles in various cellular processes. thus, identification of ppis is critical for deciphering the molecular mechanisms and further providing insight into biological processes. although a variety of high-throughput experimental techniques have been developed to identify ppis, existing ppi pairs by experimental approaches only cover a small fraction of the whole ppi networks, and further, those approa ...201627571061
management of gastric and duodenal neuroendocrine tumors.gastrointestinal neuroendocrine tumors (gi-nets) are rare neoplasms, like all nets. however, the incidence of gi-nets has been increasing in recent years. gastric nets (g-nets) and duodenal nets (d-nets) are the common types of upper gi-nets based on tumor location. g-nets are classified into three distinct subgroups: type i, ii, and iii. type i g-nets, which are the most common subtype (70%-80% of all g-nets), are associated with chronic atrophic gastritis, including autoimmune gastritis and he ...201627570419
new advances in targeted gastric cancer treatment.despite a decrease in incidence over past decades, gastric cancer remains a major global health problem. in the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gast ...201627570417
identification of dna methyltransferase genes in human pathogenic bacteria by comparative genomics.dna methylation plays an important role in gene expression and virulence in some pathogenic bacteria. in this report, we describe dna methyltransferases (mtases) present in human pathogenic bacteria and compared them with related species, which are not pathogenic or less pathogenic, based in comparative genomics. we performed a search in the kegg database of the kegg database orthology groups associated with adenine and cytosine dna mtase activities (ec: 2.1.1.37, ec: 2.1.1.113 and ec: 2.1.1.72) ...201627570304
serum vaca antibody is associated with risks of peptic ulcer and gastric cancer: a meta-analysis.increasing studies have investigated the relationship between the status of h. pylori vaca antibody and risks of peptic ulcer disease (pud) and gastric cancer (gc). however, the results were controversial. the aim of this meta-analysis is to clarify whether serum vaca antibody is associated with risks of pud and gc.201627568203
increased oxidative stress in the proximal stomach of patients with barrett's esophagus and adenocarcinoma of the esophagus and esophagogastric junction.oxidative stress (os) is an essential element in the pathogenesis of barrett's esophagus (be) and its transformation to adenocarcinoma (eac). the state of os in the proximal stomach of patients with be and eac is unknown. isoprostanes are a specific marker of os not previously used to determine os from be/eac tissue samples.201627567957
lysyl oxidase isoforms in gastric cancer.gastric cancer (gc) is the fifth most frequent cancer in the world and shows the highest incidence in latin america and asia. an increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in gc. in this review, we focus on the expression levels of lysyl oxidase isoforms, its functions and the clinical implications in gc. finding novel proteins related to the pro ...201627564724
helicobacter pylori eradication therapy, the reasonable first line therapy for gastric mucosa-associated lymphoid tissue lymphoma irrespective of infection status and disease stages. 201627563015
coronary artery disease and helicobacter pylori infection: should we consider eradication therapy as cardiovascular prevention strategy? 201627573593
dietary patterns are associated with helicobacter pylori infection in chinese adults: a cross-sectional study.previous studies indicated that food consumption was associated with helicobacter pylori infection, but no study has yet investigated the association between helicobacter pylori infection and dietary patterns. the aim of this study was to evaluate the associations between helicobacter pylori infection and dietary patterns in tianjin, china. the final cross-sectional study population comprised 10407 participants. dietary consumption of participants was assessed via food frequency questionnaire. f ...201627573193
host shp1 phosphatase antagonizes helicobacter pylori caga and can be downregulated by epstein-barr virus.most if not all gastric cancers are associated with chronic infection of the stomach mucosa with helicobacter pylori caga-positive strains(1-4). approximately 10% of gastric cancers also harbour epstein-barr virus (ebv) in the cancer cells(5,6). following delivery into gastric epithelial cells via type iv secretion(7,8), the caga-encoded caga protein undergoes tyrosine phosphorylation on the glu-pro-ile-tyr-ala (epiya) motifs initially by src family kinases (sfks) and then by c-abl(9,10). tyrosi ...201627572445
diagnosis of helicobacter pylori-related chronic gastritis, gastric adenoma and early gastric cancer by magnifying endoscopy.evaluating the prevalence and severity of gastritis by endoscopy is useful for estimating the risk of gastric cancer (gc). moreover, understanding the endoscopic appearances of gastritis is important for diagnosing gc due to the fact that superficial mucosal lesions mimicing gastritis (gastritis-like lesions) are quite difficult to be detected even with optimum preparation and the best technique, and in such cases tissue biopsy is often not very accurate for the diagnosis of gastric epithelial n ...201627577845
comparison of endoscopic based diagnosis with helicobacter urease test for helicobacter pylori infection.helicobacter pylori is an important risk factor for gastritis, peptic ulcers and gastric cancer. the prevalence in developed countries is lower than 40 % but higher than 80 % in some developing countries. it is 75 % in ghana. the helicobacter urease test (hut) is performed at endoscopy and gives an accurate diagnosis. the hut is not routinely done at our facility and presumption of h. pylori is made based on endoscopic findings and h. pylori eradication prescribed, as the incidence in the genera ...201627576901
expression of helios in gastric tumor cells predicts better survival in gastric cancer patients.helios belongs to ikaros family, which plays an important role in the cell-fate decision and control cell proliferation; abnormal expressions in leukemia are associated with poor prognosis. in this study, we investigated the helios expression between helicobacter pylori infection and prognosis in gastric cancer patients.201627576507
in vitro and in vivo bactericidal activity of tinospora sagittata (oliv.) gagnep. var. craveniana (s.y.hu) lo and its main effective component, palmatine, against porcine helicobacter pylori.tinospora sagittata (oliv.) gagnep. var. craveniana (s.y.hu) lo (tsg) is a traditional chinese herb that has been used for the treatment of upper respiratory tract infection and has anti-bacterial and anti-ulcer activity. our study investigated the bactericidal effects of tsg and its major component, palmatine, against a helicobacter pylori (h. pylori) strain isolated from pig and the standard strain h. pylori ss1 in vitro and in vivo.201627576439
prospective identification of helicobacter pylori in routine gastric biopsies without reflex ancillary stains is cost-efficient for our health care system.despite the recommendation of expert gastrointestinal pathologists, private and academic centers (including our own) have continued to use ancillary stains for identification of helicobacter pylori. for a 1-month period, gastric biopsies were prospectively evaluated for h pylori using routine hematoxylin and eosin (h&e) and a reflex diff-quik stain. during this time, 379 gastric biopsies were collected on 326 patients. h pylori organisms were prospectively identified in 23 (7%) patients, all of ...201627574809
does the antibody production ability affect the serum anti-helicobacter pylori igg titer?to investigate the relationship between serum titers of anti-helicobacter pylori (h. pylori) immunoglobulin g (igg) and hepatitis b virus surface antibody (hbsab).201627574567
update on diagnostic value of breath test in gastrointestinal and liver diseases.in the field of gastroenterology, breath tests (bts) are used intermittently as diagnostic tools that allow indirect, non-invasive and relatively less cumbersome evaluation of several disorders by simply quantifying the appearance in exhaled breath of a metabolite of a specific substrate administered. the aim of this review is to have an insight into the principles, methods of analysis and performance parameters of various hydrogen, methane and carbon bts which are available for diagnosing gastr ...201627574563
circulating micrornas: potential and emerging biomarkers for diagnosis of human infectious diseases.micrornas (mirnas) are evolutionary conserved, small non-coding rna with size ranging from 19 to 24 nucleotides. they endogenously regulate the gene expression at the post transcriptional level either through translation repression or mrna degradation. mirnas have shown the potential to be used as a biomarker for the diagnosis, prognosis, and therapy of infectious diseases. many mirnas have shown significantly altered expression during infection. the altered expression of mirna level in an infec ...201627574520
inhibition of helicobacter pylori glu-trna(g)(ln) amidotransferase by novel analogues of the putative transamidation intermediate.glutaminyl-trna(g)(ln) in helicobacter pylori is formed by an indirect route requiring a noncanonical glutamyl-trna synthetase and a trna-dependent heterotrimeric amidotransferase (adt) gatcab. widespread use of this pathway among prominent human pathogens, and its absence in the mammalian cytoplasm, identify adt as a target for the development of antimicrobial agents. we present here the inhibitory properties of three dipeptide-like sulfone-containing compounds analogous to the transamidation i ...201627586694
antimicrobial susceptibility and clarithromycin resistance patterns of helicobacter pylori clinical isolates in vietnam.helicobacter pylori is a gastric pathogen that causes several gastroduodenal disorders such as peptic ulcer disease and gastric cancer.  eradication efforts of h. pylori are often hampered by antimicrobial resistance in many countries, including vietnam.  here, the study aimed to investigate the occurrence of antimicrobial resistance among h. pylori clinical isolates across 13 hospitals in vietnam.  the study further evaluated the clarithromycin resistance patterns of h. pylori strains.  in orde ...201627583131
safety and efficacy of vonoprazan-based triple therapy against helicobacter pylori infection: a single-center experience with 1118 patients. 201627582888
clinical risk factors for gastroduodenal ulcer in romanian low-dose aspirin consumers.background. aspirin use for cardiovascular or cancer prevention is limited due to its gastrointestinal side effects. objective. our prospective, observational case-control study aims to identify the predictive factors for ulcers in low-dose aspirin consumers (75-325 mg/day). methods. the study included patients who underwent an upper digestive endoscopy and took low-dose aspirin treatment. results. we recruited 51 patients with ulcer (ulcer group) and 108 patients with no mucosal lesions (contro ...201627579036
severity of gastric mucosal atrophy is the major determinant of plasma ghrelin level in hemodialysis patients.ghrelin, an orexigenic hormone, has multiple favorable functions including protein anabolism enhancement, anti-inflammatory actions, and cardiovascular protection. a low plasma ghrelin level is associated with increased mortality in patients treated with hemodialysis (hd). however, it is unclear whether the plasma ghrelin level in hd patients correlates with the severity of gastric mucosal atrophy and helicobacter pylori status.201627578611
helicobacter pylori eradication? 201627590693
systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated epiya-motifs in caga of east asian-type helicobacter pylori strains.highly virulent strains of the gastric pathogen helicobacter pylori encode a type iv secretion system (t4ss) that delivers the effector protein caga into gastric epithelial cells. translocated caga undergoes tyrosine phosphorylation by members of the oncogenic c-src and c-abl host kinases at epiya-sequence motifs a, b and d in east asian-type strains. these phosphorylated epiya-motifs serve as recognition sites for various sh2-domains containing human proteins, mediating interactions of caga wit ...201627590005
early attempts to eradicate helicobacter pylori after endoscopic resection of gastric neoplasm significantly improve eradication success rates.after endoscopic resection (er) of gastric tumors, eradication of helicobacter pylori (h. pylori) infection is advised to reduce metachronous recurrence. optimal timing of such therapy (yet to be established) was investigated herein, examining early active and late scarring stages of post-er iatrogenic ulcers.201627588679
[fermented milk can act as adjunctive therapy for helicobacter pylori infection: a meta-analysis].to systematically evaluate the clinical effect of cultured milk products as adjunctive therapy in the anti- helicobacter pylori (h. pylori) treatment.201627592583
helicobacter pylori infection, h19 and linc00152 expression in serum and risk of gastric cancer in a chinese population.gastric cancer (gc) is a consequence of multifactorial and multistep processes. helicobacter pylori (h. pylori) infection plays a crucial role in gastric carcinogenesis. long non-coding rnas (lncrnas) have shown great potential as powerful cancer biomarkers. to investigate the possible roles of lncrnas and h. pylori infection in gc development, we measured expression levels of three lncrnas (h19, linc00152, uc001lsz) in serum from a total of 285 chinese participants using reverse transcription-q ...201627592063
an unusual presentation of gastric mucosa-associated lymphoid tissue (malt)-type lymphoma.mucosa-associated lymphoid tissue (malt)-type lymphoma is a relatively rare disease; nevertheless, it is the third most common lymphoma type, accounting for 5-7% of all non-hodgkin lymphomas. case series and retrospective analysis published in the literature have suggested that extra gastrointestinal (gi) malt-type lymphoma can occur simultaneously with malt-type lymphoma involving the gi tract. we report the case of a healthy, 64-year-old caucasian male who presented with progressive fatigue, n ...201627609718
[radiotherapy for localized gastric and orbital malt lymphomas].primary gastric and orbital malt lymphomas are both low grade (indolent) b-cell non-hodgkin's lymphomas. traditionally, these tumors are radiosensitive and have a good prognosis. in localized orbital and stages ie-iie gastric malt lymphomas without helicobacter pylori infection or in case of persistent h. pylori infection after eradication therapy, several retrospective studies have shown that radiotherapy was an effective and well-tolerated treatment.201627614509
to evaluate of the effect of adding licorice to the standard treatment regimen of helicobacter pylori.the aim of this study was to evaluate the effect of licorice in h. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (pud) or non-ulcer dyspepsia (nud) in comparison to the clarithromycin-based standard triple regimen.201627614124
helicobacter pylori-induced changes in microtubule dynamics conferred by α-tubulin phosphorylation on ser/tyr mediate gastric mucosal secretion of matrix metalloproteinase-9 (mmp-9) and its modulation by ghrelin.regulation of matrix metalloproteinase-9 (mmp-9) secretion in response to proinflammatory challenge remains under a strict control of factors that affect the stability dynamics of the major cytoskeleton polymeric structures, microtubules (mts). in this study, we report that h. pylori lps-elicited induction gastric mucosal mmp-9 secretion is accompanied by the enhancement in mt stabilization as evidenced by the increase in α-tubulin acetylation and detyrosination while the modulatory influence of ...201627613723
helicobacter pylori infection and pre-eclampsia in a romanian study group. 201627612532
direct detection of helicobacter pylori in biopsy specimens using a high-throughput multiple genetic detection system.we evaluated the direct high-throughput multiple genetic detection system (dhmgs) for helicobacter pylori in gastric biopsies.201627599152
comment on "characteristics and risk factors of helicobacter pylori associated gastritis: a prospective cross-sectional study in northeast thailand". 201627598784
helicobacter pylori and gastric cancer. 201627597945
[efficient approach to dyspepsia]. 201627596198
an aggressive form of malt lymphoma of the stomach with pancreas infiltration.malt lymphoma accounts for 7-8% of all b-cell lymphomas and at least 50% of primary gastric lymphoma, with the highest incidence at between 50 and 60 years of age. aggressive forms are rare, as are indications for multi-visceral resection.201627594756
j. robin warren: helicobacter pylori and peptic ulcer. 201627594194
prevalence and risk factors of gallbladder polypoid lesions in a healthy population.to determine the prevalence of and investigate the risk factors for gallbladder (gb) polypoid lesions in a healthy population.201627593864
anti-hsp60 antibody responses based on helicobacter pylori in patients with multiple sclerosis: (ir)relevance to disease pathogenesis.in view of published data suggesting that helicobacter pylori (hp) is a trigger of multiple sclerosis (ms), we assessed anti-heat shock protein 60 (hsp60)hp antibody reactivity in 129 ms patients and 48 demograpically-matched healthy controls (hcs). anti-hp antibodies by elisa were more elevated in ms than hcs but did not differ between different ms phenotypes. all anti-hp-positive ms sera, irrespectively of their clinical phenotype, were anti-anti-hsp60 positive. anti-hsp60 hp seropositivity co ...201627609271
structural features of dna are conserved in the promoter region of orthologous genes across different strains of helicobacter pylori.promoter regions play a key role in the process of transcription initiation and gene expression, hence promoter identification is an inherent component of the genome annotation process. identification and characterization of promoters in fully sequenced genomes is a challenging and complex task. an analysis of sequence-dependent dna structural properties in the promoter region of orthologous and non-orthologous genes can help in characterizing promoters and also provide insights into transcripti ...201627609228
gastric cancer: somatic genetics as a guide to therapy.gastric cancer is the leading cause of cancer-related mortality across the world, with poor prognosis and a median overall survival of ≤12 months for advanced stage gastric cancer. environmental, genetic and other predisposing factors contribute to the development of gastric cancer and a predominant factor was found to be infection of helicobacter pylori advances in understanding the deranged signalling pathways that are critical for normal cellular homeostasis helped in the development of novel ...201627609016
helicobacter pylori infection is associated with high methane production during lactulose breath test.despite a growing interest toward the interplay between h. pylori and gastric microbiota, few data are available about this correlation. the aim of this study was to explore the relationship between h. pylori infection and gas production during lactulose breath test.201627608906
factors associated with gastro-duodenal disease in patients undergoing upper gi endoscopy at the korle-bu teaching hospital, accra, ghana.there is a high prevalence of gastro-duodenal disease in sub-saharan africa. peptic ulcer disease in dyspeptic patients, 24.5%, was comparable to prevalence of gastro-duodenal disease among symptomatic individuals in developed countries (12 - 25%). limited data exists regarding its associated risk factors despite accumulating evidence indicating that gastroduodenal disease is common in ghana.201627605979
helicobacter catalase devoid of catalytic activity protects the bacterium against oxidative stress.catalase, a conserved and abundant enzyme found in all domains of life, dissipates the oxidant hydrogen peroxide (h2o2). the gastric pathogen helicobacter pylori undergoes host-mediated oxidant-stress exposure, and its catalase contains oxidizable methionine (met) residues. we hypothesized catalase may play a large stress-combating role independent of its classical catalytic one, namely quenching of harmful oxidants through its recyclable met residues, resulting in oxidant protection to the bact ...201627605666
engineering bioinspired bacteria-adhesive clay nanoparticles with a membrane-disruptive property for the treatment of helicobacter pylori infection.we present a bioinspired design strategy to engineer bacteria-targeting and membrane-disruptive nanoparticles for the effective antibiotic therapy of helicobacter pylori (h. pylori) infection. antibacterial nanoparticles were self-assembled from highly exfoliated montmorillonite (emmt) and cationic linear polyethyleneimine (lpei) via electrostatic interactions. emmt functions as a bioinspired 'sticky' building block for anchoring antibacterial nanoparticles onto the bacterial cell surface via ba ...201627605059
endoscopic gastritis, serum pepsinogen assay, and helicobacter pylori infection.endoscopic findings of the background gastric mucosa are important in the helicobacter pylori-seroprevalent population. it is strongly correlated not only with the risk of gastric cancer, but also with the excretion ability of gastric mucosa cells. in noninfected subjects, common endoscopic findings are regular arrangement of collecting venules, chronic superficial gastritis, and erosive gastritis. in cases of active h. pylori infection, nodularity on the antrum, hemorrhagic spots on the fundus, ...201627604795
endoscopic gastric atrophy is strongly associated with gastric cancer development after helicobacter pylori eradication.risk factors for gastric cancer during continuous infection with helicobacter pylori have been well documented; however, little has been reported on the risk factors for primary gastric cancer after h. pylori eradication. we conducted a retrospective, endoscopy-based, long-term, large-cohort study to clarify the risk factors for gastric cancer following h. pylori eradication.201627604367
population evolution of helicobacter pylori through diversification in dna methylation and interstrain sequence homogenization.decoding of closely related genomes is now revealing the process of population evolution. in bacteria, population divergence appears associated with a unique set of sequence-specific epigenetic dna methylation systems, often within restriction-modification (rm) systems. they might define a unique gene expression pattern and limit genetic flux between lineages in population divergence. we addressed the contribution of methylation systems to population diversification in panmictic bacterial specie ...201627604221
helicobacter pylori infection and ischemic heart disease: could experimental data lead to clinical studies?despite the remarkable advances made in primary prevention and treatment, ischemic heart disease (ihd) remains the leading cause of death and a significant cause of disability in developed countries. since traditional cardiovascular risk factors failed to predict all cases of ihd, there is an intensive research to explore other potential etiologic factors. among these, numerous studies have considered the theoretical link between ihd and chronic infections, including helicobacter pylori (h. pylo ...201627603552
ménétrier disease manifested by polyposis and involved in both the small bowel and entire colon: a case report.ménétrier disease (md) is rare that is involved in both the small bowel and entire colon.201627603362
does helicobacter pylori eradication play a role in immune thrombocytopenia?helicobacter pylori infection has been implicated as trigger or disease modifier in immune thrombocytopenia (itp). so, eradication treatment for this agent could have clinical benefits. searching in epistemonikos database, which is maintained by screening 30 databases, we identified four systematic reviews comprising 40 studies addressing the question of this article overall, including one randomized controlled trial. we combined the evidence using meta-analysis and generated a summary of findin ...201627603101
alteration in methylation pattern of retinoblastoma 1 gene promotor region in intestinal metaplasia with or without helicobacter pylori and gastric cancer patients.helicobacter pylori, intestinal metaplasia (im), and gene methylation play important roles in gastric carcinogenesis. however, the association among h. pylori infection, im, gastric cancer (gc), and gene methylation is not fully understood. cell cycle control involving retinoblastoma 1 (rb1) gene is one of the main regulatory pathways reported to be altered in gastric carcinogenesis.201627629734
helicobacter pylori status among patients undergoing gastroscopy in rural northern alberta.to determine the helicobacter pylori status of patients who underwent gastroscopy.201627629690
inflammatory and apoptotic regulatory activity of tanshinone iia in helicobacter pylori-infected cells.helicobacter pylori infections induce host cell inflammation and apoptosis, however, they are conflicting. tanshinone iia is an active compound of salvia miltiorrhiza bge. in this study, we investigated the regulatory effects of tanshinone iia on h. pylori-induced inflammation and apoptosis in vitro. tanshinone iia treatments (13.6-54.4[formula: see text][formula: see text]m) significantly decreased nuclear factor kappa b (nf-kb) and mitogen-activated protein kinase (mapk) [p-38 and c-terminal j ...201627627918
the prevalence of helicobacter pylori infection in symptomatic children: a 13-year observational study in the lower silesian region.helicobacter pylori (h. pylori) infection is very common worldwide, with varying frequency. according to data from epidemiological reports, a third of the population of children in poland are infected with h. pylori before the age of 18. in recent years, a decrease in the incidence of h. pylori infection in both children and adults has been observed in many countries.201627627564
analysis of patients with helicobacter pylori infection and the subsequent risk of developing osteoporosis after eradication therapy: a nationwide population-based cohort study.previous studies have reported conflicting results on the association between helicobacter pylori infection and osteoporosis. a few studies have discussed the influence of h. pylori eradication therapy on bone mineral density.201627626940
a case of undifferentiated-type mucosal gastric cancer with multiple lymph node metastases fulfilling the curative criteria for endoscopic resection according to routine pathological analysis.endoscopic resection is accepted as the standard treatment for early mucosal gastric cancer, and its indications have recently been expanded while its long-term outcomes are still unclear. herein, we present a didactic case of undifferentiated-type mucosal gastric cancer fulfilling the expanded indication and curative criteria for endoscopic submucosal dissection (esd), having synchronous multiple lymph node metastases.201627624552
relation between helicobacter pylori infection and severe pre-eclampsia complicated by intrauterine growth restriction in a rural area in egypt.the purpose of this study was to evaluate the association of helicobacter pylori (hp) infection with severe pre-eclampsia (pe) complicated by intrauterine growth restriction using rapid stool antigen test in a rural area in egypt. maternal stool samples were collected from 50 pregnant women diagnosed with pe-associated intrauterine growth restriction (iugr) and from 50 women with healthy pregnancies (control) between 34 and 38 weeks of gestation. hp stool antigen (hpsa) was measured using a mono ...201627624279
association between helicobacter pylori seropositivity and mild to moderate copd: clinical implications in an asian country with a high prevalence of h. pylori.helicobacter pylori infection is a major cause of gastric diseases. the clinical implications of h. pylori infection in various diseases outside the gastrointestinal system have also been reported, including in some respiratory disorders. in this study, we investigated the seroprevalence of h. pylori in patients with mild to moderate copd in an asian country with a high prevalence of h. pylori infection. also, we aimed to elucidate the association between the seroprevalence of h. pylori and the ...201627621611
a creative helicobacter pylori diagnosis scheme based on multiple genetic analysis system: qualification and quantitation. 201627621151
dietary composition influences incidence of helicobacter pylori-induced iron deficiency anemia and gastric ulceration.epidemiologic studies have provided conflicting data regarding an association between helicobacter pylori infection and iron deficiency anemia (ida) in humans. here, a mongolian gerbil model was used to investigate a potential role of h. pylori infection, as well as a possible role of diet, in h. pylori-associated ida. mongolian gerbils (either h. pylori infected or uninfected) received a normal diet or one of three diets associated with increased h. pylori virulence: high-salt, low-iron, or a c ...201627620719
modeling infectious diseases and host-microbe interactions in gastrointestinal organoids.advances in stem cell research have allowed the development of 3-dimensional (3d) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. bridging the gap between 2-dimensional (2d) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting infla ...201627640087
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