Publications

influence of frame size and zeranol on growth, compositional growth and plasma hormone characteristics.	a 2 x 2 factorially arranged trial was conducted to compare effects of implant (zeranol) and frame size on weight and compositional gain, and plasma hormone concentrations. angus, charolais x hereford and hereford x angus yearling steers (34 steers averaging 270 kg body weight) were randomly assigned to treatments of small (sf) vs large frame (lf) and implant (i) vs no implant (ni). steers were implanted at 0 and 97 d and individually fed an 81% whole shelled corn and 11.5% corn silage-based die ...	1987	3312138
immunohistochemical analysis of hla antigens and mononuclear infiltrates of benign and malignant breast.	using immunohistochemistry, the epithelial expression of hla class i and ii antigens (and beta 2 microglobulin) was compared in benign and malignant breast, and the stromal lympho-histiocytic infiltrate of these tissues quantified. the findings were compared with certain characteristics of the carcinomas. in contrast to other studies, malignancy was found to be associated with a far greater infiltrate of both lymphocytes and macrophages. in carcinomas, lymphocyte but not macrophage numbers showe ...	1987	3312546
genetic recombination between closely linked makers of bacteriophage t4. iv. mutations which interfere with mismatch repair.	t4 phage mutations mco1 and mco3 reduced recombination between multiple closely linked markers preferentially and were located between gene 24 and gene 25. the mco1 and the mco3 mutants complemented each other. the results of uv-cross reactivation experiments indicated that the mco1 and the mco3 mutants could rescue the markets of uv-damaged phage, but could not segregate them from flanking mutations. therefore, it is concluded that mco1 mutation and mco3 mutation interfere with mismatch repair.	1987	3312727
mutational specificity of a bacteriophage t4 dna polymerase mutant, mel88.	several bacteriophage t4 dna polymerase mutants have been shown to increase the frequency of spontaneous mutations (speyer et al. 1966; freese and freese 1967; de vries et al. 1972; reha-krantz et al. 1986). in order to determine the molecular basis of the mutator phenotype, it is necessary to characterize the types of mutations produced by the mutator dna polymerases. we show here that at least one dna polymerase mutator mutant, mel88, induces an increased number of base substitution mutations ...	1987	3312960
competition between sigma factors for core rna polymerase.	the switch of rna polymerase specificity from early to late promoters of bacteriophage t4 is achieved by substitution of host sigma factor, sigma 70, with the t4 induced factor, sigma gp55. however, overproduction of sigma gp55 from an expression vector is not detrimental to escherichia coli growth. direct competition binding assays demonstrate that sigma 70 readily displaces sigma gp55 from rna polymerase and thereby reverses the promoter specificity of the enzyme. the displacement also occurs ...	1987	3313282
plasma thyroid hormones, thyroid stimulating hormone, and insulin during acute hypometabolic states in man.	acute behavioral rest states in man are associated with marked hormonal and metabolic changes. in order to complete a hormonal profile of these states and to identify possible metabolic regulators, we measured thyroid hormones (t3 and t4), thyroid stimulating hormone (tsh), and insulin during the stylized mental practice of "transcendental mediation" (tm) and during ordinary unstylized eyes closed rest. except for tsh, which declined acutely, hormone levels were normal and stable throughout the ...	1987	3313447
[current tsh-sensitive assays simplify thyroid diagnosis].	the methodology and clinical application of sensitive tsh assays are discussed. the new immunometric assays not only distinguish between normal and elevated, but also between normal and suppressed tsh values. therefore, after clinical examination of the patient, serum tsh measurement by a sensitive assay may be used as a first line test whenever hypo- or hyperthyroidism is suspected. normal tsh indicates euthyroidism and obviates the need for further thyroid function testing. in patients with el ...	1987	3313695
immunohistological study of mononuclear cell infiltrate in malignant gliomas.	sixty-five malignant gliomas (astrocytomas grade 3 and 4 and glioblastomas) were examined by means of immunoperoxidase staining on frozen tissue using various monoclonal antibodies directed against macrophages, lymphocytes and natural killer cells. depending on the antibody used, the presence of macrophages in tumours ranged from 85%-100%. many of the tumours contained substantial numbers of macrophages not only, as expected, in necrotic areas but also in intact tumour tissue. eighty-nine percen ...	1987	3314311
generation of leishmania-specific short-term t-cell lines derived from peripheral blood of cured american cutaneous leishmaniasis patients.	the putative protective immune response in localized cutaneous leishmaniasis caused by leishmania braziliensis braziliensis (lbb) was analysed by generation of short term t-cell lines from peripheral blood lymphocytes (pbl) of three patients. all had had active skin lesions but were clinically cured at the time of study. pbl were stimulated in vitro with sonicated lbb promastigotes; blasts were isolated after 5 days and propagated for 9 to 16 days before being tested for proliferative capacity. ...	1987	3314910
the function of zinc in gene 32 protein from t4.	gene 32 protein (g32p), the single-stranded dna binding protein from bacteriophage t4, contains 1 mol of zn(ii) bound in a tetrahedral complex to -s- ligands, proposed on spectral evidence to include cys-77, cys-87, and cys-90 [giedroc, d. p., keating, k. m., williams, k. r., konigsberg, w. h., & coleman, j. e. (1986) proc. natl. acad. sci. u.s.a. 83, 8452]. the zn(ii) can be completely removed by treatment with the mercurial reagent p-(hydroxymercuri)benzenesulfonate and ethylenediaminetetraace ...	1987	3314985
deoxyhexanucleotide containing a vinyl chloride induced dna lesion, 1,n6-ethenoadenine: synthesis, physical characterization, and incorporation into a duplex bacteriophage m13 genome as part of an amber codon.	organic synthesis and recombinant dna techniques have been used to situate a single 1,n6-ethenoadenine (epsilon ade) dna adduct at an amber codon in the genome of an m13mp19 phage derivative. the deoxyhexanucleotide d[gct(epsilon a)gc] was chemically synthesized by the phosphotriester method. mild nonaqueous conditions were employed for deprotection because of the unstable nature of the epsilon ade adduct in aqueous basic milieu. physical studies involving fluorescence, circular dichroism, and 1 ...	1987	3314993
diagnosis and treatment of hypothyroidism in children.	congenital hypothyroidism is a relatively common endocrine disorder, affecting one in 4000 newborn infants. undiagnosed and untreated congenital hypothyroidism will result in un-toward consequences, including mental retardation and other significant neurologic sequelae. for these reasons, programs to screen newborns were developed to detect congenital hypothyroidism before clinical features become obvious enough to suggest the diagnosis. the most common clinical features include prolonged jaundi ...	1987	3315407
serum thyroglobulin concentration in patients with diabetes mellitus.	the serum thyroglobulin (tg) concentration was measured in 97 patients with diabetes mellitus (39 males, 58 females). hyper tg-nemia which exceeds the normal range (1.0-26.6 ng/ml) was observed in 10 patients (3 out of 21 cases treated with diet alone, 3 out of 50 cases treated with oral hypoglycemic agents, 4 out of 26 cases treated with insulin). there was no significant correlation between concentrations of serum tg and triiodothyronine (t3), thyroxine (t4), fasting plasma glucose (fpg), and ...	1987	3315639
the effect of triiodothyronine (t3) and thyroxine (t4) upon insulin secretion from isolated rat pancreatic islets.	in order to observe the effect of triiodothyronine (t3) or thyroxine (t4) on glucose-induced insulin release from pancreatic islets, isolated pancreatic islets from wistar male rat were incubated in modified krebs-ringer bicarbonate solution (0.2% bsa, ph 7.4) with 3 mm, 5 mm or 10 mm glucose for 60 min with or without exposure to t3 (2.5 micrograms/ml or 7.5 micrograms/ml) or t4 (2.5 micrograms/ml or 7.5 micrograms/ml). direct exposure of isolated pancreatic islets to t3 or t4 did not have any ...	1987	3315642
diisopropanolnitrosamine (dipn) induced rat thyroid lesions. iii. an immunohistochemical study on their functional aspects.	the functional aspects of dipn induced rat thyroid lesions classified as in our previous studies were analyzed by immunohistochemical detection of tg, t4, and t3 in serial or semi-serial paraffin sections. the type 1 lesions, i.e., foci of cellular alteration of individual follicles, showed the same pattern of immunostaining as seen in the surrounding hyperplastic follicles and in normal controls. on the other hand, the type 3 lesions, i.e., carcinomas, were mostly negative for t4 and t3 with on ...	1987	3318273
restoration of u.v.-induced excision repair in xeroderma d cells transfected with the denv gene of bacteriophage t4.	the heritable dna repair defect in human xeroderma d cells, which results in failure to incise at u.v. light-induced pyrimidine dimers, has been partially but stably corrected by transfection of immortalised cells with the denv pyrimidine dimer glycosylase gene of bacteriophage t4. transfectants selected either for a dominant marker on the mammalian vector carrying the prokaryotic gene or for the dominant marker plus resistance to killing by u.v. light, have been shown to express the denv gene t ...	1987	3319581
thyrotropin-secreting pituitary tumors.	tsh tumors are associated with both hypothyroid and hyperthyroid states. the proposed mechanism of thyrotroph secretion is illustrated in figure 8. pituitary enlargement in hypothyroidism is usually due to reactive hyperplasia and correlates with the degree of tsh elevation. although this often translates to long-standing hypothyroidism and severe symptoms, this is not always the case. patients may be asymptomatic or present with other endocrine syndromes. children may have precocious puberty, a ...	1987	3319602
malignant lymphomas in patients with autoimmune diseases: a report of 6 cases and a review of the japanese literature.	six patients with malignant lymphomas in autoimmune diseases are described. four patients who had sjögren's syndrome (ss) alone or with progressive systemic sclerosis (pss) or rheumatoid arthritis (ra) developed non-hodgkin's lymphomas of the b cell type. one patient who had systemic lupus erythematosus (sle) developed a b cell lymphoma. another patient with chronic thyroiditis (chtd) and idiopathic thrombocytopenic purpura (itp) had a t cell (okt3/t4) lymphoma. in 5 patients, the autoimmune dis ...	1987	3320428
glucoregulatory hormone response to insulin-induced hypoglycaemia following long-term calcium antagonism with felodipine in patients with essential hypertension.	the effect of 8 weeks' treatment with the dihydropyridine calcium antagonist felodipine on glucoregulatory hormone response following insulin-induced hypoglycaemia was evaluated in 7 patients with essential hypertension, who grade i-ii. after an iv insulin injection (0.1 iu/kg), blood glucose decrement and nadir were similar before and during felodipine treatment. basal glucagon, noradrenaline, adrenaline, gh and cortisol levels were unchanged, and the response to insulin-induced hypoglycaemia w ...	1987	3321819
observation of a possible pause mutant in the total synthesis of t4 lysozyme.	a dna of 495 bp coding for t4-lysozyme was chemically synthesized and cloned in escherichia coli. on dna sequence analysis, clones ptly.10 and ptly.9 were identified to contain identical and complete t4-lysozyme coding sequences except that ptly.9 had an additional 23 bp inverted repeat dna at the 3'-end of the coding sequence. on expression and purification under similar conditions, t4-lysozymes from these two clones showed different degrees of retention time on hplc as well as in the rate of e ...	1987	3322274
iron deficiency in the elderly.	iron deficiency in the elderly almost always results from blood loss. the loss of iron can be viewed as occurring in four stages, which are reflected in the different tests used to diagnose iron deficiency. tests used to diagnose iron deficiency have certain limitations regarding their ability to detect iron deficiency before the overt anaemia occurs. the tests which diagnose iron deficiency most accurately are low serum ferritin and reduced iron staining of a bone marrow aspirate. because iron ...	1987	3322440
an immunochemiluminometric assay for serum free thyroxine.	an immunochemiluminometric assay has been developed for the measurement of free t4 concentrations in serum. the assay uses chemiluminescent acridinium ester labelled monoclonal antibodies which react with free t4 in the sample. a t4-rabbit immunoglobulin g conjugate competes for antibody binding sites, immune-complexes containing this being isolated using an anti-immunoglobulin g antibody coupled to paramagnetic particles. associated chemiluminescence intensity is thus dependent on the free t4 c ...	1987	3322610
[differences in the effectiveness of levothyroxine preparations].	three proprietary preparations of l-thyroxine were tested for their bioequivalence in a cross-over trial. comparing the two most commonly prescribed preparations, during administration of preparation b (euthyrox) serum concentrations of basal thyrotropin (tsh) was significantly higher than with preparation a (l-thyroxin henning) in both subgroups and in the cross-over calculation, as well as after stimulation with thyrotropin-releasing hormone (trh) in one of the subgroups. during administration ...	1987	3322763
activation of a cryptic 5' splice site in the upstream exon of the phage t4 td transcript: exon context, missplicing, and mrna deletion in a fidelity mutant.	a collection of 100 td mutants defective in phage t4 thymidylate synthase (ts) production was screened for splicing impairments. splicing-defective mutants were identified by a rapid assay developed to detect imbalances in the td protein products (ts, the exon ligation product, and nh2ts, encoded by the pre-mrna). thirteen selected mutants, confirmed to be splicing defective by an rna-oligodeoxynucleotide hybridization assay, were all shown to be inhibited in the first step of the group i splici ...	1987	3322941
localization of the t4 phage ribonucleotide reductase b1 subunit gene and the nucleotide sequence of its upstream and 5' coding regions.	the nucleotide (nt) sequence in a 757-bp [corrected] segment downstream from the intron-containing t4 phage thymidylate synthase gene (td) has been determined. this region was found to contain two open reading frames (orfs). the first orf(orf2) [corrected] 261 bp [corrected] in length, is 24 [corrected] nt downstream from the td gene. the second orf(orf3) [corrected]) is 200 bp long at 558 [corrected] nt from the td gene and extends to the end of the eco ri fragment. the amino acid (aa) sequence ...	1987	3322944
an improved method for the inhibition of endogenous peroxidase non-deleterious to lymphocyte surface markers. application to immunoperoxidase studies on eosinophil-rich tissue preparations.	the inhibitory effect of phenylhydrazine and azide combined with either pre-formed or nascent hydrogen peroxide h2o2 upon endogenous peroxidatic activity, expressed by tissue eosinophils in different disease states, was investigated. it was found that whilst endogenous peroxidatic activity due to eosinophils in a hodgkin's disease and a histiocytosis x case were adequately inhibited by phenylhydrazine combines with pre-formed or nascent h2o2, the eosinophils in the onchocerca volvulus nodule wer ...	1987	3323139
[spontaneous course of metachronous metastases following curative intervention for colonic cancer: a total review].	the rate of metachronous metastases after curative surgery because of colonic carcinomas was 17% (n = 70). women (20%) developed metastases more frequently than men (13%). procedures in third to ninth decennium were followed in decreasing frequency (100 to 8.7%) by metachronous metastases. primary tumors located in coecum showed by far the strongest tendency to recurrent metastatic disease (29%). rate of metastases after curative surgery in tumorstage t 1-3 n0m0 was 9%, after stage t4 n0 m0 17% ...	1987	3323746
structure and thermal stability of phage t4 lysozyme.		1987	3323816
restriction alleviation and enhancement of mutagenesis of the bacteriophage t4 chromosome in recbcsbca strains of escherichia coli.	the restriction of non glucosylated phage t4 dna is reduced significantly in host bacterial strains carrying recbcsbca mutations even in the presence of a functional rgl gene. in recbcsbca hosts a high frequency of phage mutations are observed both in the glucosyl transferase genes and in the dna sequences recognized by the rgl restriction enzymes. this hypermutagenic property of the recbcsbca strains is not dependent on the glucosylation of the phage dna, and the mutagenesis is localized to cer ...	1987	3323824
[a case of pituitary hyperplasia associated with primary hypothyroidism].	a thirteen-year-old girl was admitted complaining of short stature and anemia. the low titers of her serum t3 and t4 and the abnormally high tsh level represented primary hypothyroidism. although she had normal sellar size, ct demonstrated an intra- and suprasellar round mass with homogeneous enhancement. with thyroid replacement therapy the enhanced mass diminished on ct within 5 months, and her symptoms regressed. twelve cases with radiological diminution of pituitary mass or visual field impr ...	1987	3323937
intravesical ultrasound for staging bladder tumours.	intravesical ultrasonic scanning was performed in 74 patients with 84 bladder tumours. two tumours located, respectively, at the neck and in the dome of the bladder could not be visualized. in the other 82 the degree of infiltration was ultrasonically assessable. the tumours could be assigned to three categories: superficial, noninfiltrating (ta to t1), infiltrating the bladder wall (t2 to t3a) and infiltrating extravesically (t3b to t4). the stage was correctly determined with intravesical ultr ...	1987	3324302
pathogenesis of human immunodeficiency virus infection and prospects for control.	in just six years after the initial description of the acquired immunodeficiency syndrome, much has been learned about the etiologic agent, the human immunodeficiency virus. the pathogenic mechanisms utilized by this virus to infect selectively and persistently t4+ lymphocytes and monocyte/macrophages, leading to immunodeficiency and neurologic dysfunction, are slowly becoming clear. better understanding of the pathogenesis of human immunodeficiency virus infection is essential for the rational ...	1987	3324508
[autoimmune neutropenia disclosing aids in a child].	a 15 month old child with a history of multiple infectious diseases was admitted to hospital for investigation of pyrexia and general ill health. she was anaemic with a persistent neutropaenia associated with hypergamma globulinemia, indicating intense autoimmune activity: cellular immunity was abnormal with a normal total lymphocyte count but a very low t4/t8 ratio. hiv serology was positive; the virus was isolated from a lymph node biopsy specimen. the parents for the child were hiv positive a ...	1987	3324845
effect of thyroid hormones on angiotensinogen production in the rat in vivo and in vitro.	the influence of thyroid hormones on angiotensinogen production was studied in vitro and in vivo. in the in-vitro system, angiotensinogen production rate (apr) of monolayer cultures of rat hepatocytes in response to tri-iodothyronine (t3) and thyroxine (t4) was assayed. in the in-vivo system, plasma angiotensinogen concentration (pac) and liver angiotensinogen content (lac) were measured in hyper- and hypothyroid rats. in both thyroid dysfunctions, a significant decrease of pac was found compare ...	1987	3325607
energy and protein relations in the broiler. 5. lipogenesis, glucose production and metabolic hormone levels as functions of age and dietary protein levels.	both a decrease in the dietary carbohydrate level and an increase in the protein level decrease lipogenesis in chicks. interpreting results of previous experiments can be confounded by alterations in the quantity of carbohydrate because as protein was added to the diets used in these studies, carbohydrate was decreased. in the present study, diets containing 13, 16, 19 or 23% protein and 70% carbohydrate calories were fed to ross male chicks from 1 to 4 weeks of age to determine the effect of di ...	1987	3326797
the essential role of recombination in phage t4 growth.		1987	3327469
prolactin, growth hormone and thyrotropin-thyroid hormone secretion during stress states in man.	changes in hormone secretion and/or metabolism almost constantly accompany stressful events. the hormonal response to stress is directly related to the intensity of the stimulus, and greatly depends on the individual's perception of potentially stressful situations. hypoglycaemia, surgery and exercise represent physical, metabolic and psychological stressful events where the activation of the endocrine system plays a great role. these endocrine responses also include the secretion of gh and prol ...	1987	3327498
cellular mechanism of action of thyroid hormones.	it has emerged in the last decade that the molecular mechanism of action of thyroid hormones resembles that of steroids; thyroid hormones indeed exert their effects mainly by directly regulating gene expression, on association with specific chromatin-bound receptors. of the two thyroid hormones, thyroxine (t4) appears to be a sort of prohormone, whereas triiodothyronine (t3) seems to be the active form; in this respect, t4-deiodination, which occurs at the level of the target tissues, may be cru ...	1987	3328725
affinity chromatography on immobilized anhydrotrypsin: general utility for selective isolation of c-terminal peptides from protease digests of proteins.	recently we have succeeded in the efficient isolation of the c-terminal peptides from tryptic digests of the tail sheath protein (with c-terminal gly) and the tube protein (with c-terminal glu) of bacteriophage t4, by taking advantage of a unique property of immobilized anhydrotrypsin, that is, a strong specific affinity for peptides containing arg or lys residues at their c-termini. in this study, the utility of affinity chromatography on immobilized anhydrotrypsin was further demonstrated in t ...	1987	3329196
thyroxine (t4) and triiodothyronine (t3) metabolism in normal subjects from rio de janeiro, brazil.	kinetic studies of t4 and t3 metabolism were performed on 5 healthy volunteers from rio de janeiro to obtain normal values for thyroid hormone metabolism. 125i-t4 and 131i-t3 were administered in bolus and blood samples taken during 7 days. circulating tracers were isolated by sephadex g-25 chromatography. the kinetic parameters of t4 and t3 metabolism were calculated by noncompartmental methods. metabolic clearance rates were 1.04 l/day for t4 and 20.7 l/day for t3. the daily production rate wa ...	1987	3330463
genetic delineation of functional components of the group i intron in the phage t4 td gene.		1987	3331339
[human acquired immunodeficiency syndrome (aids)].	this work, intended primarily for dentists, provides detailed information on the mechanism of action of the aids virus, its epidemiology and most common routes of infection, the clinical manifestations of hiv infection, and related oral lesions of relevance to the dentist. the work also recommends ways in which dentists can aid in diagnosis, avoid contaminating patients, and avoid being infected themselves by seropositive patients. the article begins by describing retroviruses and their mode o ...	1987	3333954
hierarchical strategy for protein folding and design: synthesis and expression of t4 lysozyme gene and two putative folding mutants.	a t4 lysozyme-coding dna sequence of 495 bp was chemically synthesized and cloned by ligation of 26 deoxyribooligonucleotide fragments in two steps with a linearized plasmid followed by transformation. on selection by colony hybridization and dna sequence analysis, clone ptly.10 was identified to contain a complete t4 lysozyme synthetic dna. on expression under lac-promoter, unfused t4 lysozyme was obtained in approximately 4-6% yield. the design and synthesis of two putative folding mutants, fl ...	1987	3334099
[interrelation of the thyroid and calcium-regulating functions in patients with diffuse toxic goiter].	a comparative analysis of thyroid and calcium regulating functions in the diffuse toxic goiter was performed. at the initial stage tsh reaction to trh was on a decrease in parallel with a sharp increase in the content of t4 t3. two-third of the patients revealed an increase in the level of calcitonin resulting in an increase in the ratio of calcitropic hormones. in that case the content of ionized calcium was not increased. in one-third of the patients the level of calcitonin showed a tendency t ...	1987	3422931
[effect of chronic stress during pregnancy on the thyroid status of mother and progeny].	the effect of chronic stress (electric stimulation) in the second half-period of pregnancy on the status of the hypophyseothyroid system of mother and her progeny was studied. experiments were staged on 100 pregnant rats and their progeny aged 20 days, 1, 2, 3 and 6 mos. the content of thyroxine (t4), triiodothyronine (t3) and thyrotropic hormone (tth) in the blood of mother (in the midterm and at the end of pregnancy) and progeny was determined by a radioimmunoassay. chronic stress during pregn ...	1987	3422944
[neuropathological study of 31 cases of acquired immunodeficiency syndrome].	post-mortem study of every patient who died from aids in pitié-salpêtrire hospital from june 1984 to november 1985 was performed without regard to the presence of neurological signs and symptoms. autopsy were performed in 31/48 cases. patients had been hospitalized in the departments of parasitology-infectious disease (24 cases) internal medicine (4 cases) and neurology (3 cases). in every case, formalin-fixed material from the brain and the spinal cord were embedded in paraffin (20 samples), st ...	1987	3423582
chronic antiepileptic drug therapy: classification by medication regimen and incidence of decreases in serum thyroxine and free thyroxine index.	results are described on the association of decreased serum total thyroxine (t4) and free thyroxine index (fti) with antiepileptic drug therapy in a group of randomly selected chronically medicated outpatients (n = 291). for monotherapy subgroups (n = 164), the highest incidence (t4, 23.9%; fti, 25.4%) of below normal values occurred in patients medicated with carbamazepine (cbz), followed by phenytoin [(pht) t4, 13.2%; fti, 7.9%], and phenobarbital [(pb) (t4, 3.4%; fti, 0%]. no t4 and fti value ...	1987	3424405
[cancers of the soft palate. results of repeat surgery].	between 1960 and 1983, 270 patients were treated at the curie institute for a carcinoma of the soft palate, including 260 by radiotherapy (mean dose: 69 gy). most of these tumours were t1 t2 (201 cases, 76%). there was a high frequency of a past history of carcinoma (38 cases, 14%) as well as of simultaneous carcinomas (44 cases, 16%). two months after radiotherapy, a velar tumor persisted in 29 patients whilst 1 patient had deep necrosis. 15 of these 30 patients underwent secondary surgical exc ...	1987	3426052
[results of operations of salvage laryngectomy].	the surgery of the larynx in an irradiated neck changed since 30 years by an evolution of the radiotherapeutic technics and the surgical procedures. at the curie institute, from 1960 to 1986, 230 patients were operated with laryngectomy for failure of the first treatment (average doses: 70 gy). 29 had partial laryngectomy. the feeding tube was removed before 6 weeks in 78% of the patients. 19 patients (8%) died in the 3 months after surgery (8 carotid blow-up). the crude survival rates are 70% a ...	1987	3426064
preoperative irradiation in oral cavity carcinoma. a study with special reference to dna pattern, histological response and prognosis.	the relation between dna pattern and response to preoperative radiotherapy was studied in 51 patients with oral squamous cell carcinomas operated 4 weeks after irradiation. small tumors (t1 and t2) showed more pronounced response to radiotherapy than larger ones (t3 and t4), as did dna aneuploid tumors. eight of 11 dna aneuploid tumors showed no remaining tumor in the operation specimen, compared to 6 of 21 dna polyploid and 2 of 19 dna diploid tumors. none of 16 patients without demonstrable re ...	1987	3426846
age-associated changes of t lymphocyte subsets.	the percentage and the absolute number of t3, t4, t6, t8, and t10 lymphocytes of the peripheral blood were determined in 100 children (3 days to 10 years), 29 adults (18 to 59 years), and 30 elderly individuals (60 to 98 years). the percentage of the various t lymphocyte subsets and t4/t8 lymphocyte ratio for the children and elderly did not differ statistically from adults, except for the proportion of t4 lymphocytes which was higher in the subgroup with 3 days of age. the absolute number of to ...	1987	3427775
effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis.	twelve patients with subacute thyroiditis were divided into two groups and treated with prednisolone or salicylate. the initially elevated t4, t3, free t4 (ft4), free t3 (ft3) and erythrocyte sedimentation rate (esr) were reduced during the early phase within about 4 weeks in both groups. the serum levels of thyroglobulin (tg) were elevated in both groups treated with salicylate and prednisolone (252 +/- sd 117 ng/ml and 233 +/- sd 157 ng/ml, respectively) at initial examination. the serum level ...	1987	3427792
amiodarone and thyroid hormone effects on anterior pituitary hormone gene expression.	amiodarone therapy results in marked changes in circulating thyroid hormone and tsh concentrations in man. in the present study we have demonstrated that amiodarone treatment of the rat increases serum tsh and pituitary cytoplasmic concentrations of tsh beta and alpha subunit messenger rnas (mrnas) and reduces prl mrna as measured by cytoplasmic dot hybridization with specific complementary (c) dna probes. the fall in circulating tsh and tsh mrna resulting from thyroid hormone treatment was less ...	1987	3427795
different scalp localization of pattern onset and reversal visual evoked potentials.	visual evoked potentials were recorded monopolarly from seven electrodes on a horizontal line from t3 to t4 and bipolarly in one channel from left of the midline to right of the midline. stimulation of the right and left half-fields was performed with a checkerboard generator of 10 degrees x 13.5 degrees and checks of various sizes at high contrast. the results may be summarized as follows: 1. source-sink analysis for lateral half-field pattern onset with small checks shows c1, peaking about 80 ...	1987	3428085
similar concentrations of thyroidal iodothyronines and t3/t4 ratio in normal thyroids from two yugoslav districts with different iodine intake.	in spite of different daily iodine intake in two yugoslav districts (littoral-split 297 +/- 76 (mean +/- sd) and continental-zagreb 111 +/- 36 micrograms/g creatinine, p less than 0.001), thyroidal iodothyronine concentrations and t4/t3 ratio in normal post mortem thyroids were comparable. t4 was 260.0 +/- 42.6 micrograms/g w.w. (mean +/- se) in split group vrs. 279.9 +/- 59.4 in zagreb. t3 was 12.8-2.0 vrs. 12.8 +/- 2.2 and t4/t3 ratio 21.6 +/- 1.9 vrs. 21.1 +/- 2.9 in split and zagreb, respect ...	1987	3428366
hyperresponsiveness of residual thyroid lobe of hemithyroidectomised rat to thyrotropin.	the effects of hemithyroidectomy and thyrotropin administration on rat thyroid gland function were studied in adult male rats. immediately after surgery or sham operation rats were treated daily with 0.12 iu of bovine thyrotropin (tsh) for 3 or 5 days. in control rats tsh dose applied resulted in an increase in serum t4 level at day 5 of experiment. serum thyroxine concentration markedly decreased in sham operated and hemithyroidectomised rats, an effect observed at days 3 and 5 of experiment. t ...	1987	3428865
lowering of t3 and rise in reverse t3 induced by hyperglucagonemia: altered thyroid hormone metabolism, not altered release of thyroid hormones.	recently we reported that hyperglucagonemia induced by glucagon infusion causes a decline in serum t3 and a rise in reverse t3 in euthyroid healthy volunteers. these changes in t3 and rt3 levels were attributed to altered t4 metabolism in peripheral tissues. however, the contribution of altered release of thyroid hormones by the thyroid gland could not be excluded. since the release of thyroid hormones is inhibited in primary hypothyroidism and is almost totally suppressed following l-thyroxine ...	1987	3428867
clinical analysis of ureteral tumours with or without renal pelvic neoplasms.	twelve patients with ureteral tumours with or without ipsilateral renal pelvic neoplasms were retrospectively analysed. haematuria was the most common symptom. location of all tumours was preoperatively detected by conventional diagnostic methods, such as intravenous or retrograde pyelography, washing cytology of the upper urinary tract, computed tomography, echogram and abdominal aortography. cumulative proportion survivals of 1, 3 and 5 years were 81.9%, 68.2% and 45.5%, respectively. patients ...	1987	3429164
intrinsic abnormality of thyroid cells from a patient with a brobdingnagian goiter.	thyrocytes from normal and goitrous portions of the thyroid gland from a patient with an enormous (635 gm) goiter were cultured in media, and their relative abilities to uptake thymidine, synthesize dna, and secrete tg and t4 were assessed. tg, t4 and the ratio tg/t4 in media at 72 h were 120 micrograms/dl, 1.6 micrograms/dl and 75 for normal cells, and 410 micrograms/dl and 273 for goitrous cells. dna synthesis was 30-100% greater in goitrous than normal cells over a period of 72 h indicating a ...	1987	3429790
comparative thyroid function in adult japanese quail and ring doves: influence of dietary iodine availability.	thyroid function was studied in japanese quail, coturnix japonica, and ring doves, streptopelia risoria, when both were fed the same dietary iodine (i; 930 micrograms i/kg). we also compared thyroid function in groups of doves receiving low i (less than 100 micrograms i/kg) or moderate i (930 micrograms i/kg). we measured thyroid gland (tg) weight, tg stable i content, tg 125i uptake, and 125i labeling of thyroid hormones. triiodothyronine (t3) and thyroxine (t4) concentrations in tgs and serum ...	1987	3430122
immune-neuroendocrine interactions during aging: age-dependent thyrotropin-inhibiting activity of thymosin peptides.	thymosin fraction 5 (tf-5), a partially purified thymic preparation, has been previously shown to have luteinizing hormone-releasing hormone (lh-rh)-releasing activity in perfused rat hypothalamus as well as in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. we report here the effect of tf-5 on the tsh-thyroid axis in young (3 months) and old (25 months) sprague-dawley male rats. conscious free-moving animals carrying an indwelling atrial cannula received a single d ...	1987	3431174
measurement of total triiodothyronine (t3), total thyroxine (t4) and thyroid-stimulating hormone (tsh) levels in lead-exposed workers.		1987	3431862
application of an immunoradiometric assay for thyrotrophin in evaluation of thyroidal and nonthyroidal disease states.	we evaluated an immunoradiometric assay for serum tsh (irma-tsh) and compared it with established indices of thyroid function in 208 patients with either frank thyroid disease, conditions of abnormal thyroxine protein binding, or conditions which are known to produce discordant thyroid results, viz. pregnancy or estrogen treatment and nonthyroidal illness (nti). as expected, a wide scatter of tsh results was found in treated thyroid disease: 53 patients (53%) from both groups (initially hypo- or ...	1987	3431910
effect of thyroidectomy on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced lipid peroxidation.	thyroid hormones have been implicated in the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd). therefore, the effects of methimazole (mmi) and propylthiouracil (ptu) induced hypothyroidism and surgical thyroidectomy on several toxic manifestations of tcdd were investigated. female rats were treated with mmi (0.50 mg/kg) for 10 or 28 days, or ptu (5.0 mg/kg) for 10 days. other animals were surgically thyroidectomized. the animals received tcdd (100 micrograms/kg) orally or the corn oil vehi ...	1987	3432353
serum and intracystic levels of thyroxine (t4) and triiodothyronine (t3) in women with breast macrocysts.	in 15 patients with a total of 22 breast macrocysts serum and intracystic t4 and t3 and intracysts tsh were concomitantly radioimmunoassayed (using a technique with polyethylene glycol (peg) for t3, t4, and a double antibody technique for tsh). while in most cysts (17/22) the t4 values were under those in the serum, in 21 cysts t3 was 2-18 times above the serum values. intracystic tsh was at the lower limit of the normal serum tsh values whereas prolactin (prl) and thyroglobulin (tgl) assayed in ...	1987	3432987
recurrence, progression and survival in bladder cancer. a retrospective analysis of 232 patients with greater than or equal to 5-year follow-up.	a retrospective study of 232 bladder tumours with minimum follow-up 5 years is presented. the carcinoma was superficial in 66%, muscle-invasive in 31% and could not be staged in 3%. primary treatment was mainly transurethral resection for superficial tumour, but was cystectomy or radiotherapy in 22 of 29 t1 g3. of the superficial tumours, 71% recurred. progression to higher t stage occurred in 15% of ta and 29% of t1 tumours, and half of these patients died of bladder cancer. the corrected 5-yea ...	1987	3433019
diagnostic value of bronchoalveolar lavage in ocular sarcoidosis.	bronchoalveolar lavage (bal) is an investigation which has already proven its value in the diagnosis and follow-up of patients with pulmonary sarcoidosis. it also appears to be a valuable contribution to the diagnosis of patients presenting with ocular sarcoidosis. we evaluated the findings in bal in 16 cases with suspected ocular sarcoidosis (14 cases of uveitis, one with eyelid-swelling and one with an inflammatory process of the lacrimal gland). bal was positive in 11 cases e.g. showed a lymp ...	1987	3434243
papillary carcinoma of the thyroid. a histochemical, immunohistochemical and ultrastructural study with special reference to the follicular variant.	twenty-one papillary thyroid carcinomas (ptcs), grouped into predominantly papillary (14 cases), predominantly follicular (5 cases), and extremely follicular, i.e., follicular variant (2 cases) types, were studied in comparison with three cases each of follicular lesions including follicular carcinoma, follicular adenoma, adenomatous goiter and graves' disease. histochemical, immunoperoxidase, and electron microscopic analyses demonstrated no remarkable differences between the predominantly papi ...	1987	3434281
subarachnoid block with hyperbaric lignocaine. a comparison with hyperbaric bupivacaine.	a double-blind study was carried out in 20 patients to compare 5% hyperbaric lignocaine and 0.5% hyperbaric bupivacaine for subarachnoid block. the injections were made in the lateral position and the patients turned supine immediately. the onset, extent and duration of sensory and motor blockade, the quality of anaesthesia, cardiovascular effects and the frequency of side effects were studied. cephalad spread of analgesia was high (t4-5) with both solutions. bupivacaine produced a longer durati ...	1987	3434739
inhibition of hepatic deiodination of thyroxine is caused by selenium deficiency in rats.	selenium (se) deficiency produced up to a 14-fold decrease in hepatic tri-iodothyronine (t3) production from thyroxine (t4) in vitro. the t3 production rate could not be restored by the addition of a variety of cofactors, nor by the addition of control homogenate. the impairment in hepatic t3 production observed in se deficiency was reflected in the concentrations of thyroid hormones circulating in plasma, t4 being increased approx. 40% and t3 being decreased by 30%. however, the fall in plasma ...	1987	3435458
dynamics of cortisol receptor activity in the gills of the brook trout, salvelinus fontinalis, during seawater adaptation.	injection of cortisol into freshwater-adapted brook trout caused a rapid increase in plasma cortisol and a significant drop in plasma osmolality, thyroxine (t4), and chloride concentrations, but a nonsignificant drop in plasma triiodothyronine (t3). concomitantly, cortisol cytosolic receptor activity decreased and cortisol nuclear extract receptor activity increased significantly. transfer of brook trout into 30% seawater evoked a significant rise in plasma cortisol, osmotic, and chloride concen ...	1987	3436518
variation in thyroid response to thyroid-stimulating hormone in juvenile coho salmon (oncorhynchus kisutch).	changes in the circulating levels of thyroid hormones measured by radioimmunoassay in yearling coho salmon in response to injection of bovine thyroid-stimulating hormone (tsh) were evaluated from january through august. doses of tsh ranging from 0.2 to 6.4 micrograms/g body wt were ineffective in stimulating t4 in january and at one time in april. responses to tsh injection at this dose range were observed beginning in february and continuing through august. the minimal effective dose of tsh was ...	1987	3436520
identification of the rna polymerase-binding site on genome rna of influenza virus.	the binding sites for influenza viral rna polymerase on genome rna segments were investigated. ribonucleoprotein (rnp) cores containing the rna polymerase were isolated from detergent-treated virions by glycerol gradient centrifugation. on apg-primed in vitro transcription by the isolated rnp cores, different levels of rna transcripts were synthesized for the eight rnp cores, suggesting an uneven distribution of the rna polymerase. 3'-terminal labeling of the rnp cores with the use of [32p]pcp a ...	1987	3436966
studies on the monoexponential nature of the left ventricular pressure fall during isovolumic relaxation period in the diseased heart.	our recent clinical studies on the negative dp/dt upstroke pattern suggested that the left ventricular pressure (lvp) deviated from the exponential curve during isovolumic relaxation period (irp) in diseased hearts. to examine this further two types of monoexponential curve fitting were done in various heart diseases (normal (n): 8, angina pectoris (ap): 8, myocardial infarction (mi): 13, hypertrophic cardiomyopathy (hcm): 10, dilated cardiomyopathy (dcm): 8). lvp was measured by a millar's cath ...	1987	3437504
[endocrine changes in children with acute viral hepatitis].	the paper is concerned with the results of hormonal studies on virus hepatitis in 84 children aged 2 to 14, of them 28 had a mild form of disease, 50--medium grave and 6--a severe form of disease. a study was made of the blood content of acth, sth, tsh, cortisol, aldosterone, t3, t4, prolactin, and alpha-fetoprotein. the hormones were determined by a radioimmunoassay using sorin kits (france). a considerable increase in the blood content of acth, cortisol, aldosterone and a moderate increase in ...	1987	3438265
[the course of experimental thyrotoxicosis at high altitude].	a radioimmunoassay showed that the stay of intact animals in the highlands (the pass of tuya-ashu, 3200 m) was accompanied by phase changes in the blood content of the thyroid hormones and thyrotropin (tsh). an increase in the t4 concentration in the blood of healthy animals on the first days of adaptation was determined by thyroid activation. further on thyroid activity suppression was observed in parallel with a decrease in the production of the thyroid hormones. the thyroid of animals with th ...	1987	3438275
changes in liver calcium content in relation to serum triiodothyronine (t3), thyroxine (t4) and t3/t4 ratio in rats treated with ccl4.	to evaluate the relation between liver calcium content and microsomal function in liver injury, we determined liver calcium content, serum triiodothyronine (t3), thyroxine (t4), t3/t4 ratio and serum glutamic pyruvic transaminase (sgpt) content in rats treated with ccl4. the t3/t4 ratio decreased from 1.9 to 1.2 at 6 hr after treatment, but elevated immediately to 3.2 at 36 hr after, and returned to normal at 54 hr after treatment. the calcium content increased from 27 micrograms/g wet weight to ...	1987	3438576
composition of diet modifies toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) in cold-adapted rats.	the effect of a high carbohydrate, high fat or high protein diet was studied on the acute toxicity of tcdd (125 micrograms/kg) in cold-adapted (4 +/- 1 degrees c) rats. within 10 days after dosing, tcdd-treated rats fed a high carbohydrate or a high protein diet reduced their caloric intake by 25% whereas those fed a high fat diet consumed only 15% fewer kcal/mbs (metabolic body size). tcdd-treated rats fed a high protein diet lost body weight at the same rate as their pair-fed controls, whereas ...	1987	3439872
pyramidal cortical cell morphology studied by multivariate analysis: effects of neonatal thyroidectomy, ageing and thyroxine-substitution therapy.	the changes produced on the whole dendritic morphology of layer iii cortical pyramidal neurons by neonatal hypothyroidism, induced in rats by thyroidectomy at 10 days of age (t), as well as those changes related to ageing, have been studied in rats at 40 and 80 days of age. for these purposes, the dendritic structure of these neurons was defined by a set of 10 variables whose measurements were analyzed using multivariate methods. the effect of tyroxine (t4) substitution therapies applied to t ra ...	1987	3440202
iodothyronine-5'-deiodinase activity in progenies of hypothyroid rats.	iodothyronine-5'-deiodinase activity (i-5'da) was measured in the progenies of control rats, hypothyroid (tx) rats, and hypothyroid treated with ovine gh (tx + gh) during gestation. the enzyme was measured in cerebral cortex and cerebellum at 22 days gestation and at 5, 10, 30 and 60 days postpartum. in addition, the pituitary i-5'-da was assessed in the postnatal animals. the experiments were undertaken because the tissues of the progenies of rats that were hypothyroid during pregnancy appeared ...	1987	3440566
existence of extrathyroidal conversion inhibitor (iec) in starved animals and its influence on thyroid hormones deiodination in liver and kidney in vitro.	to find out whether an inhibitor of extrathyroidal conversion of iodothyronines is present in sera of starved animals, pig liver and kidney homogenates were incubated with t4, t3 or rt3 and dithiotreitol in the presence of evaporated diethyl ether extracts of sera obtained from fed and starved (1-12 days) rabbits. sera extracts of short-term (1-4 days) starved rabbits caused a significant inhibition of t4 to t3 conversion (54% on day 3) and t4 to rt3 deiodination (52% on day 2) in liver homogena ...	1987	3440567
evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness (nti): studies using turpentine oil-injected rat.	sprague-dawley rats were treated with saline or turpentine oil (5 mu 1/g bw sc at 3-day intervals x3) with or without replacement doses of t4 (0.8 g/100 g bw/day ip) or t3(0.3 microgram/100 g bw/day ip). injection of turpentine oil to the rat consistently caused a significant reduction in serum total t4, total t3, free t4 index and tsh. despite marked changes in thyroidal economy in experimental rat, iodothyronine 5'-monodeiodinating activity (ma) in the liver, the kidney and the hearth and the ...	1987	3440823
diagnosis of amiodarone-iodine-induced thyrotoxicosis(aiit) associated with severe nonthyroidal illness.	a rare case of amiodarone-iodine-induced thyrotoxicosis (aiit) associated with nonthyroidal illness is reported. serum total thyroxine (tt4) and free t4 (ft4) concentrations were elevated and serum tsh was undetectable as frequently observed also in euthyroid amiodarone-treated patients. at variance with common forms of aiit, serum total triiodothyronine (tt3) was reduced due to low-t3 syndrome. the laboratory diagnosis was made on the basis of elevated free t3 (ft3) levels. thus, in patients wi ...	1987	3440824
genetic conversion of g.c base-pairs to a.u base-pairs in a transfer rna.	the cloverleaf stem segments of the suppressor gene of bacteriophage t4 trna(gln) contain ten g.c and ten a.u base-pairs. to gain a better appreciation of the g.c base-pair requirement, we isolated multiple mutants of this suppressor gene in which base-pairs of g.c were replaced by a.u. one active suppressor gene contained only a.u base-pairs on the anticodon stem, indicating that g.c base-pairs in this region of trna(gln) are not essential for function. in contrast, replacement was not possible ...	1987	3441013
neuroendocrine responses to cold stress in normal subjects and depressives.	in order to assess the effects of cold stress on neuroendocrine function in persons with affective disorders, 11 normal subjects and eight depressed patients were subjected to a well-defined thermal stress in a cold chamber at 10 degrees c. metabolic rate, skin and rectal temperature, and tsh, t4, t3, growth hormone, prolactin, and cortisol were measured simultaneously for 45 minutes prior to cold exposure and for 60 minutes in the cold. all subjects experienced robust changes in skin temperatur ...	1987	3441586
endocrinological abnormalities in myotonic dystrophy: consecutive studies of eight tolerance tests in 26 patients.	we studied endocrine functions of the hypothalamus, pituitary, thyroid, gonad, adrenal and pancreas in 26 patients with myotonic dystrophy. the following findings were obtained: (1) hyporesponsivenesses of hgh to insulin, arginine and l-dopa test were observed in 25%, 45% and 54.5% of patients, respectively. to the administration of sulpiride and trh, hypo- or hyperresponses of plasma prl were observed in 4 or 2 patients, respectively. (2) depressed plasma levels of testosterone were observed in ...	1987	3441927
[model substrates of enzymes modifying ribonucleic acids. synthesis of deca- and undecanucleotid-fragments of 21-member oligoribonucleotide simulating t psi c-branch of yeast valine trna].	decanucleotide (ap)6gptpupc and undecanucleotide gpapupcpcp (up)5u have been synthesised. they constitute 5'- and 3'-parts of a 21-mer which imitates t psi c-arm of yeast trna(val1) and is a potential substrate for m1a-methylases and pseudouridine synthetase. the oligonucleotide blocks, synthesised enzymatically by means of ribonucleases of various substrate specificity and polynucleotide phosphorylases (tpupc, apupcpc, pgptpupc, gpapupcpc) or obtained by hydrolysis of poly(u) and poly(a) with s ...	1987	3442571
monosynaptic excitation of thoracic motoneurones by inspiratory neurones of the nucleus tractus solitarius in the cat.	1. the connection between inspiratory neurones in the ventrolateral nucleus tractus solitarius (n.t.s.) and intercostal motoneurones was examined. 2. descending axonal projections to contralateral t3-t5 spinal segments were found for 110 of 142 (77%) ventrolateral n.t.s. neurones examined. 3. antidromic mapping was used to locate the axons of thirty-nine ventrolateral n.t.s. neurones in t4, and evidence for axon collaterals was found for thirty-two of forty-seven (68%) neurones examined. axon co ...	1987	3443941
in situ analysis with monoclonal antibodies of lymphocyte subsets in myocardial biopsies from patients with dilated cardiomyopathy and idiopathic (viral) myocarditis.	this light- and electron-microscopic immunohistochemical study using monoclonal antibodies analyzes of the in situ lymphocyte subsets in endomyocardial biopsies from 11 patients with dilated cardiomyopathy (dcm) and three patients with idiopathic (viral) myocarditis (myo). in the dcm patients both leu 2a+ cytotoxic/suppressor t cells (tc/s) and leu 3+ helper/inducer t cells (th/i) were identifiable in the myocardial lesions, and mean th/i/tc/s (t4/t8) ratio was 0.7 +/- 0.6 (mean +/- sd). in 9 of ...	1987	3443989
[properties of bacteriophage t4 modified with cetyltrimethylammonium bromide].	treating of the bacteriophage t4b with cetyltrimethylammonium bromide results in extension of long fibers and contraction of tail sheaths. the unreorganized hexagonal baseplate attachment to the distal end of the tail core remains intact. such aberrantly contracted phages are shown to retain the ability to absorb on the bacterial surface. the absorption is inhibited by sucrose and does not require the presence of 1-tryptophan. the aberrantly contracted phages lose the infection ability.	1987	3447056
the amino acid sequence of crystalline sheets: a proteolytic fragment of the major head protein (gp23) of bacteriophage t4.	a peptide, obtained from t4 phage major capsid protein gp23 by chymotryptic digestion, has been shown to form two types of crystalline sheets, hexagonal and rectangular. the sheet peptide was subjected to conventional sequencing work. together with the dna sequence of gene 23, the results showed that the peptide consisted of 155 amino acids, located from 295 to 449 in the nascent gp23 and from 230 to 384 in the matured gp23.	1987	3447164
[several endocrine aspects of duodenal stasis in the process of therapeutic gymnastics].	the levels of tth, t3, t4 and testosterone were studied in 65 female patients suffering from chronic duodenitis with concomitant hypertensive duodenal stasis, stages i and ii. a significant increase in the content of the hormones under study was revealed. subclinical hyperthyroidism was determined by the formation of the irritative autonomic (sympathicotonic) syndrome as a result of irritation of the sympathetic nerve fibers of the celiac plexus due to the presence of inflammation at the duodeno ...	1987	3447293
carbamazepine (tegretol) inhibits in vivo iodide uptake and hormone synthesis in rat thyroid glands.	decreased serum concentrations of t3 and t4 occur in patients treated with the anticonvulsant drug carbamazepine (cbz), but with rare exception, these patients remain euthyroid. the mechanism that accounts for diminished hormone levels is unknown, and our objective was to study the direct effect of cbz on iodide uptake and hormone synthesis in thyroid glands of cbz-treated and pair-fed control rats. chronic ingestion (per os) of cbz in male rats reduced the four hour thyroid 131i-iodide uptake b ...	1987	3447884
iodine in contrast agents and skin disinfectants is the major cause for hypothyroidism in premature infants during intensive care.	in 51 sick newborns the influence of two different nonionic, iodine-containing contrast agents, amipaque (group 1) and omnipaque (group 2) and of long-term treatment with polyvinylpyrrolidone-iodine (pvp-i) (group 3) on thyroid function was studied. in the dose given, freshly dissolved amipaque releases roughly 100 micrograms 'free' iodide/kg body weight; this release may be even higher in the solubilized agent omnipaque because of increased breakdown. urinary iodine excretion was elevated in al ...	1987	3447940
[importance of the assay of t3 and t4 tears and plasma for the diagnosis of endocrine exophthalmos].	in the control subject, the thyroidal hormones have been found to be always present in similar quantities in both eyes tears. the proportion of t3 is much more important in the tears (23-40%) than in the plasma (1-2%). it is close to the concentration of deiodinated t4 found in many tissues. in ocular tissues, the t3 is thus very little or even not broken down. this led us to define the tear plasma relationship parameters. we studied lacrimo-plasmatic thyroidal parameters in cases with thyroidal ...	1987	3448120
[l-thyroxine and triiodo-l-thyronine in the cerebrospinal fluid and hypothalamo-hypophyseal axis of hyper- or hypothyroid rats].	l-thyroxine and triiodo-l-thyronine concentrations in cerebrospinal fluid (csf), hypothalamus and pituitary gland are measured in male albino-wistar rats under several experimental thyroid disfunction : including hyperthyroidism induced by l-t3 and l-t4 treatments and surgical hypothyroidism. radioimmunoassay is carried out by nejad's method modified in this work. the pattern of thyroid hormone concentrations in csf is similar to that in serum, but the values obtained are lower. thyroid hormone ...	1987	3448717
[characteristics of the development of postural asymmetry in rats as affected by the opioids met-enkephalin and the kappa-agonist bremazocine].	it has been found that bremazocine and met-enkephalin induce postural asymmetry in spinal rats under subarachnoidal and intravenous administration. intravenous administration of bremazocine to intact animals--even if after it (an hour later) their spinal cord is sectioned--produces no asymmetry, i. e. the spinal cord section is necessary for asymmetry development. the magnitude of postural asymmetry and the side of limb flexion are not constant for each animal, but they change in time. though, o ...	1987	3448843
[functional disorders of the hypothalamo-pituitary-thyroid axis in epilepsy].	changes of the hormonal functions of the axis hypothalamus-hypophysis-thyroid were assessed in epileptics prior to the beginning of the anticonvulsant therapy (50 cases), during short-lasting treatment (12 months) and during long-lasting treatment (54 cases treated during a mean period of 15.3 years). the serum levels were determined of thyreotropin (tsh), total t4, total t3, total cholesterol, and thyroxin-binding globulin capacity. the test of trh stimulation was used for the determination of ...	1987	3449769
detrimental effect of recent thyroidectomy on hemorrhagic shock and resuscitation.	shatney and coworkers, in 1984, reported that recent thyroidectomy in dogs improved survival following hemorrhagic shock induced by reservoir bleeding to a mean pressure (map) of 60 torr for 60 min. since thyroidectomy reduces preshock map, their control dogs had a relatively greater fall in map during hemorrhage. to circumvent this inequity, this study was designed to elucidate the effects of recent thyroidectomy in 20 splenectomized dogs subjected to acute hemorrhagic shock induced by phleboto ...	1987	3829326
pesticide-induced changes in peripheral thyroid hormone levels during different reproductive phases in heteropneustes fossilis.	effects of gamma-bhc (an organochlorine) and malathion (an organophosphorus) exposure on plasma triiodothyronine (t3) and thyroxine (t4) levels have been studied in the freshwater catfish, heteropneustes fossilis, during its annual reproductive cycle. after 4 weeks exposure of gamma-bhc (8 and 16 ppm) and malathion (10 and 20 ppm), the effects on plasma t3, t4, and t3/t4 ratio varied during different reproductive phases. malathion seems to have a stimulatory effect, while gamma-bhc seems to have ...	1987	3830026