Publications

optimizing selection of in vitro tests for diagnosing thyroid disorders.	the optimal utilization of the thyroid related radioimmunoassays t3, t4, and tsh-ria is derived from analysing the clinical and laboratory data for 974 patients with functional thyroid disorders. a statistical computer analysis of the contribution of each of the three tests, and in combination, to the final diagnoses of hypothyroid, euthyroid, and hyper thyroid states was designed. the best contributing test for hypothyroidism and euthyroidism was tsh-ria (98.5 and 93%, respectively). t4/t3 + ts ...	1987	3684111
[diagnosis of thyroid function in premature infants in intensive care].	in 87 premature infants of an neonatal intensive care unit (gestational age 28-37 weeks) serum-t4, -ft4 and tsh were investigated on day 10, 20 and 30 and at term respectively, in addition to the usual tsh-screening (capillary specimen) on day 5. in 47 neonates (54%) t4 and ft4 were found to be low, including all infants under 30 weeks of gestational age and all ventilated infants. screening tsh was not elevated but in some cases with iodine contamination. 12 of 13 infants in whom trh-stimulatio ...	1987	3684316
comparison of physiological responses to maximal arm exercise among able-bodied, paraplegics and quadriplegics.	a comparison of pulmonary, cardiovascular and metabolic responses was made in 32 subjects consisting of 11 able-bodied, 8 paraplegics (t4-l3 lesions) and 13 quadriplegics (c5-c8 lesions) during maximal arm cranking exercise. a progressive continuous arm cranking test, modified for each group, was employed to elicit maximal responses with pulmonary and metabolic determinations made with open circuit spirometry and selected cardiovascular measurements made by impedance cardiography. additionally, ...	1987	3684324
nicks 3' or 5' to ap sites or to mispaired bases, and one-nucleotide gaps can be sealed by t4 dna ligase.	using synthetic oligodeoxynucleotides with 3'-oh ends and 32p-labelled 5'-phosphate ends and the technique of polyacrylamide gel electrophoresis, it is shown that, in the presence of the complementary polynucleotide, an ap (apurinic or apyrimidinic) site at the 3' or the 5' end of the labelled oligodeoxynucleotides does not prevent their ligation by t4 dna ligase, although the reaction rate is decreased. this decrease is more severe when the ap site is at the 3' end; the activated intermediates ...	1987	3684572
neonatal changes in plasma cortisol, free and total iodothyronine levels in control and hypotrophic lambs.	neonatal changes in plasma free and total iodothyronines, cortisol, glucose and urea levels have been studied in 8 control (birthweight greater than or equal to 2.5 kg) and 16 hypotrophic lambs (birthweight less than 2.5 kg) receiving limited amounts of colostrum during the first 36 h of life and then fed ad libitum. during the period of colostrum feeding, plasma glucose levels were low in both groups and increased after the onset of ad libitum feeding; they were significantly lower in hypotroph ...	1987	3685619
free thyroxine, free triiodothyronine, and thyrotropin concentrations in hypothyroid and thyroid carcinoma patients receiving thyroxine therapy.	free thyroxine (ft4) and free triiodothyronine (ft3) concentrations in serum were measured by direct equilibrium dialysis methods in patients receiving thyroxine replacement or suppression therapy. four of 50 hypothyroid patients euthyroid on replacement therapy (mean thyroxine dose 120 micrograms/day) had supranormal ft4 concentrations, whereas the ft3 concentrations were normal in all. forty-one of 56 operated thyroid carcinoma patients on suppressive therapy (mean thyroxine dose 214 microgram ...	1987	3687325
blood substitution and complement activation.	complement activation was studied in 45 patients undergoing total hip arthroplasty under epidural anesthesia. the patients were randomly allocated to three groups. in group i blood loss was replaced with microaggregate-poor erythrocyte concentrate (sagm-erc) plus 3% dextran-60 as plasma substitute, and postoperative analgesia was maintained with intramuscular ketobemidone. in group ii blood loss was replaced as in group i, but epidural anesthesia was prolonged 12 h postoperatively and kept at a ...	1987	3687352
an unusual presentation of bilateral facet dislocation of the cervical spine.	we report the case of a patient who presented complaining of neck pain after a fall. initial physical examination was remarkable for an occipital scalp contusion and tenderness to palpation in the mid-cervical spine. neurological examination demonstrated an absence of response to pinprick below approximately the t4 level. upper extremities had equal withdrawal to pain and lower extremities were without movement. initial cervical, thoracic, and lumbar spine films were normal. an emergency myelogr ...	1987	3688607
[primary transmaxillary buccopharyngectomy and recovery transmaxillary buccopharyngectomy in giant cancers of the tonsilar region. apropos of 120 cases].	based on a series of 120 patients treated by trans-maxillary buccopharyngectomy for tumors (mainly t3, t4) of the tonsillar region, results are compared of primary and recovery surgery, the latter being instituted from 1981 because of the rapid strides made in new reconstructive procedures. this development markedly modified therapeutic indications, with substitution of radiotherapy as primary treatment. after primary surgery, the 3- and 5-year survival rates were globally 59 and 49% respectivel ...	1987	3688738
neoadjuvant chemotherapy before definitive treatment for stage iii carcinoma of the breast.	one hundred women with american joint committee (ajc) stage iii (t2, n2; t3, n0/1/2; t4, n0/1/2) carcinoma of the breast were treated with combination chemotherapy following biopsy to confirm the diagnosis and determine hormone receptor status before any other treatment of the local disease (so-called neoadjuvant chemotherapy). response was assessed after three cycles of treatment, and responders were treated until the tumor and/or axillary nodes failed to show further regression. definitive sur ...	1987	3689121
spinal segmental preganglionic outflow to cervical sympathetic trunk and postganglionic cardiac sympathetic nerves.	the aim of this study was to verify in which spinal cord segments the preganglionic neurones projecting to the cervical sympathetic trunk or converging onto the somata of the postganglionic cardiac sympathetic neurones are located in cats. the thoracic white rami t1 to t5 were electrically stimulated and the evoked responses were recorded in the cervical sympathetic trunks and postganglionic cardiac nerves. the responses were mostly evoked by electrical stimulation of group b preganglionic fibre ...	1987	3690262
thyroid hormone levels in panic disorder.	a history of thyroid dysfunction has been reported in patients with phobic disorders. there is also evidence of a blunted tsh response to trh stimulation in patients with panic disorder. in this study, values of t3, t4 and t7 were compared between 26 patients with panic attacks and 20 normal controls. patients were diagnosed according to dsm-iii criteria and those with a clinical history of thyroid dysfunction were excluded. patients were not on any medication when the blood samples were drawn. ...	1987	3690476
toxic effects in c57b1/6 and dba/2 mice following consumption of halogenated aromatic hydrocarbon-contaminated great lakes coho salmon (oncorhynchus kisutch walbaum).	diets containing coho salmon (oncorhynchus kisutch walbaum) from the pacific ocean or from lakes erie, michigan, and ontario [containing a gradation from low to high of halogenated aromatic hydrocarbons, (hahs)] were fed to c57b1/6 and dba/2 mice. following a 4-month dietary exposure to lake ontario salmon, both strains of mice demonstrated hepatomegaly. the ethoxyresorufin-o-deethylase (err) enzyme levels were elevated in livers of c57b1/6 mice fed diets of salmon from all of the great lakes st ...	1987	3691436
lack of effect of glucagon on t4 and t3 secretion from perfused dog thyroid lobes.		1987	3692442
central hypogonadism in burned men.	serum samples were obtained from 30 burned men at different times up to the fourth month after injury. mean concentrations of estradiol (e2) were elevated above those for healthy control subjects. mean serum total testosterone (t), sex hormone-binding globulin (shbg), bioassayable luteinizing hormone (lh), thyroxine (t4), triiodothyronine (t3) and their free indices (ft4i and ft3i) were depressed below those of controls during the first postburn week. mean values for t and lh were progressively ...	1987	3692444
influence of cigarette smoking on thyroid hormone levels.	1 serum triiodothyronine (t3), thyroxine (t4) and thyrotropin (tsh) concentrations and urinary thiocyanate levels were examined in healthy smokers and non-smokers as an indicator of smoking behaviour. smokers were subdivided into moderate and heavy. 2 significant differences in urinary thiocyanate levels were apparent between all three groups. for heavy smokers, serum t3 concentrations were significantly above the values found in non-smokers. increased serum t3 levels were not accompanied by a s ...	1987	3692496
[critical remarks on the chemotherapy of squamous cell carcinomas of the oropharynx].	the results of chemotherapy for t3 and t4 squamous cell carcinoma of the oropharynx treated by chemotherapy, surgery and irradiation (n = 19), or by surgery plus irradiation (n = 28) were analysed. the two groups were similar as regards site and extent of the tumour, but the first group had a much worse prognosis. the selection of the patients, the method and results of therapy are described. the probable reasons for the failure of the chemotherapy are discussed.	1987	3692932
phrenic and external intercostal motoneuron activity during progressive asphyxia.	phrenic and external intercostal motoneuron activities were compared during progressive asphyxia induced by the interruption of artificial ventilation in the pentobarbital-urethan-anesthetized, gallamine-paralysed rabbit. the relative augmentation of inspiratory activity of the t1-t4 external intercostal nerves was significantly greater than that of the phrenic nerve during asphyxic hyperpnea. this was associated with a greater recruitment of intercostal than of phrenic motoneurons, particularly ...	1987	3693174
protective effect of coenzyme q10 on thyrotoxic heart in rabbits.	an excess of thyroid hormone is known to produce cardiac dysfunction and failure, i.e., thyrotoxic heart. we studied the protective effect of coenzyme q10 (coq10) on the thyrotoxic heart in 29 rabbits. a group treated with 1-thyroxine sodium salt (t4; 167 micrograms/kg) for 3 weeks showed marked decreases in the myocardial content of norepinephrine (ne) and atp (0.5 +/- 0.2 microgram/g wet weight, p less than 0.05 and 31.1 +/- 2.6 nmol/mg protein, p less than 0.05, respectively) as compared with ...	1987	3693260
[brachytherapy--carcinoma of the tongue].	in a review of 193 patients with carcinoma of the tongue who underwent interstitial radiotherapy in our hospital from november 1978 to 1986, 5 year actuarial local control rate were 97%, 87%, 58% and 77% for t1, t2, t3 and t4 respectively. mucosal ulcers with tissue defects and bone exposure of the mandible occurred in 5 years after the treatments, 6%, 22%, 44%, and 100% for t1, t2, t3 and t4, respectively. therapeutic ratio was 1 in patients with t1 who underwent interstitial radiotherapy (70 g ...	1987	3694797
[intra-operative radiotherapy with excision of urinary bladder carcinoma].	from june, 1979 through oct., 1986 forty patients (32 males and 8 females) with cancer of the urinary bladder have been treated by intraoperative radiotherapy (iort) after surgical excision of their tumors. the five-year survival rate, by the kaplan-meier method, was 100% in grade i patients (n = 6), 56% in grade ii (n = 19), 49% in grade iii and 58% in all patients, respectively. similarly, it was 62% for 33 patients in stages t1 and t2 of the disease and 42% for 7 patients graded t3 and t4 of ...	1987	3694809
the mechanism for producing two symmetries at the head-tail junction of bacteriophages: a hypothesis.	some double-stranded dna bacteriophages consist of dna packaged in a proteinaceous capsid. the capsid has a dna-enclosing outer shell (head) attached to an external projection (tail). at the head-tail junction is a ring of subunits (connector) that has either six or twelve-fold rotational symmetry, and is joined to the head at an axis of the head's five-fold rotational symmetry. the head is made of subunits in either an icosahedral array or an array consisting of two icosahedral hemispheres sepa ...	1987	3695545
[hormone therapy as postoperative care in patients with differentiated thyroid cancer].	tsh suppression therapy has been performed for 150 patients as postoperative care for differentiated thyroid cancer. l-thyroxine (lt4) was given in a dose of 2.1-4.8 micrograms/kg/day, per os. serum thyroid hormone determinations were done after confirming that the drug had continually been taken for more than three months. serum free t4 (ft4) values were elevated higher than the upper normal limits (1.9 ng/dl) in 127 of 150 cases (84.7%). in 100 cases of these, serum free t3 (ft3), reverse t3 ( ...	1987	3696136
purification and partial characterization of thyroid hormone binding proteins in canine serum.	thyroxine-binding prealbumin (tbpa) and thyroxine-binding globulin (tbg) were isolated from canine serum and partially characterized. tbpa was isolated by retinol-binding protein (rbp) affinity chromatography and further purified by preparative agarose gel electrophoresis or fplc ion exchange chromatography. tbg was purified by thyroxine (t4)-sepharose chromatography followed by gel filtration on sephacryl s-300 and preparative electrofocusing in a granulated dextran gel. molecular weights were ...	1987	3149232
the influence of methimazole on the thyrotrophic and peripheral activity of thyrotrophin and thyrotrophin-releasing hormone in the chick embryo and growing chicken.	plasma concentrations of thyroxine (t4) and triiodothyronine (t3) were profoundly depressed both in chick embryos and growing chickens after methimazole (mmi) treatment. there was no response of t4 and t3 levels to trh or tsh injections in the mmi group, either in embryos or growing chickens. peroxidase activity measured in the thyroid gland was significantly higher in embryos and growing chickens treated with mmi. however, neither trh nor tsh affected this activity 2 hr after injection in eithe ...	1987	3149233
[dynamics of thyroid hormones and hematological and biochemical indices in chronic nitrate poisoning in sheep].	experimental researches were carried out on sheep, fed with forage, containing 0.6% nitrate in the dry substance of the ration with the aim to follow the dynamics of the thyroid hormones, respectively the functions of the thyroid gland and its connection with some hematologic and biochemical indexes in the blood (methaemoglobin, blood sugar, carotene and vitamin a). it is ascertained that t3 and t4 decrease during the development of chronic nitrate poisoning, and the blood sugar and methaemoglob ...	1987	3450082
evaluation of a sensitive chemiluminescent assay for tsh in the follow-up of treated thyrotoxicosis.	we have studied 21 patients treated for thyrotoxicosis to evaluate a highly sensitive chemiluminescent thyrotrophin (tsh) assay in the assessment of changing thyroid status. serum tsh was generally suppressed with high serum thyroid hormone concentrations and invariably rose when free t4 and t3 fell substantially below the normal range. however tsh values in 14 of the 21 patients remained undetectable or subnormal for variable periods despite normal or even slightly subnormal free t4 and t3 valu ...	1987	3450454
delayed changes of plasma level and biliary excretion of several iodothyronines after a single administration of low doses of thyroxine in rats.	male wistar rats were injected i.p. 2.5 or 5.0 micrograms thyroxine (t4) and the level of several iodothyronines and tsh in plasma or biliary excretion of iodothyronines were estimated by radioimmunoassay in groups of animals in various intervals up to 144 hr after the administration. in general, two peaks in the plasma level and biliary excretion of iodothyronines were found: first one within 24 hr and a delayed second one between about 48 and 72 hr after the administration. it was concluded th ...	1987	3450529
studies on in-vivo capacity of thyroxine deiodinating system in rat liver: biliary excretion of several iodothyronines after increasing loading doses of thyroxine.	eighteen male rats were inserted with polyethylene tubings into bile duct and femoral vein and two rats each were injected a series of doses from 5 to 1280 micrograms l-thyroxine into a venous cannula. the bile was collected for three subsequent 2-hr periods and the excretion of total thyroxine (t4), triiodothyronines (t3 and rt3) and all diiodothyronines (3,3'-t2, 3,5-t2 and 3',5'-t2) was estimated as well as that of conjugated t4 and t3. the excretion of all compounds was considerably increase ...	1987	3450530
congenital hypothyroidism from complete iodide transport defect: long-term evolution with iodide treatment.	hypothyroidism from iodide transport deficiency is a rare disease, especially when found in two affected siblings. treatment with high doses of iodide has been recommended, but no long term results have been reported. two siblings with congenital hypothyroidism due to total failure to transport iodide have been followed up during twelve and a half years of treatment with oral potassium iodide. iodine doses varied between 10.3 and 22 mg/day, and serum total iodine concentrations between 100 and 2 ...	1987	3451231
thyroid function in fasting rats: variations in 131i uptake and transient decrease in peroxidase activity.	serum thyroxine and triiodothyronine, radioiodide thyroid uptake and thyroid peroxidase (tpo) activity were studied over a 2 to 5 day period in fasting rats treated (f+) or not (f-) with tsh. in f- rats, tpo activity was transiently decreased on the 3rd day, whereas in f+ it was always higher than in controls. on the 5th day, the 2 h thyroid uptake of 131i decreased in f-, while the 24 h uptake increased in both f- and f+. serum t3 and t4 decreased in both fasting groups. thus, not all effects o ...	1987	3451788
analysis of thyroglobulins 27s and 19s and their hormonal content in human thyroid glands.	thyroglobulins (tg) 27s and 19s and their hormonal content were determined in normal (n = 6), paranodular (n = 4) and hypofunctioning nodular (n = 8) human thyroid tissues. the proportion of tg 27s and the hormonal content of tg 19s were significantly decreased in cold nodules. in normal tissues, the molar ratio of t4 in tg 27s (2.8) was almost twice that found in tg 19s (1.7), while for t3 the molar ratio in tg 27s (0.06) was lower than in tg 19s (0.09). these results indicate that tg 27s is pr ...	1987	3451789
growth performance and concentrations of thyroid hormones and growth hormone in plasma of broilers at high temperatures.	responses of broiler chickens to a high ambient temperature (35 degrees c) were measured in two experiments. in one experiment temperatures were increased abruptly from 21 degrees c to a daily range of 21-35 degrees c whereas, in the other, temperatures were increased more gradually over 6 days. the high temperatures were maintained for 5 h/day. in both experiments, birds exposed to the high temperatures ate less food and gained less liveweight than birds maintained at 21 degrees c. efficiency o ...	1987	3453042
correlation of thyroxine and thyroid-stimulating hormone with personality measurements: a study in psychosomatic patients and healthy subjects.	a comparative study performed in psychosomatic patients and healthy subjects reveals different profiles of thyroxine (t4) and thyroid-stimulating hormone (tsh) correlations with personality measurements (minnesota multiphasic personality inventory (mmpi); sensation-seeking scale (sss), and susceptibility to punishment scale (sp). three distinct sets of results may be enumerated, namely: (1) a negative correlation between sensation-seeking and tsh; (2) a positive correlation between the most indi ...	1987	3453429
a study of thyroid hormones in women suffering from vomiting in pregnancy.	twelve pregnant women hospitalized because of hyperemesis are examined on their thyroid hormone values. pathological values of thyroxin t4 are found in seven patients (58%). the values of free t4 are elevated in only three patients and all the values of tyroxin t3 are found to be within the normal range. it is concluded that the pathological values of t4 and free t4 do not represent thyroid disease, and the mechanism of hyperemesis gravidarum is still obscure.	1987	3454502
determination of triiodothyronine (t3) and thyroxine (t4) in bangladeshi population by radioimmunoassay (ria) method.		1987	3454637
acquisition of acoustic startle response in relation to growth and thyroid function in rats.	thiourea was administered by gavage to pregnant and lactating rats from gestational day 18 until postnatal day 10, at doses of 100 or 250 mg per day (approximately 350 or 900 mg/kg/day). from the day after birth until postnatal day 14 the neonates were weighed, and beginning on postnatal day 10 acquisition of acoustic startle reflex was assessed. serum thyroxine and thyrotropin were measured on postnatal day 14. high dose thiourea severely inhibited thyroid function in pups, significantly depres ...	1987	3140595
effect of iodine intake and methimazole on lymphocytic thyroiditis in the bb/w rat.	spontaneous lt and elevated serum anti-tg occur in the diabetes prone bb/w rat, but thyroid function is essentially normal in the rats with lt. prolonged low dose mmi decreases the incidence of lt in bb/w rats. the administration of excess iodine beginning at 30 days of age markedly accelerates the occurrence of lt and anti-tg at 90 days of age. low iodine intake decreases the incidence of lt. excess iodine intake did not induce lt in w-line, wistar-furth, and sprague-dawley rats. this suggests ...	1987	3475923
a longitudinal study of anteroposterior growth changes in the palatine rugae.	palatine rugae have been used as internal dental cast reference points for quantification of tooth migration. some, but not all, investigators have reported the medial rugal region to be stable or to show predictable change. the purpose of this study was to use the longitudinal data base of the child research council of denver to examine the anteroposterior stability of the medial rugal region. dental casts of 20 females and 21 males with untreated normal angle class i occlusions were selected. ...	1987	3476625
long-term evaluation of hiv antigen and antibodies to p24 and gp41 in patients with hemophilia. potential clinical importance.	to investigate the relation between human immunodeficiency virus (hiv) antigenemia and clinical manifestations of hiv infections, we studied 96 patients with hemophilia who were positive for hiv antibody, for a median of 34 months. every 4 to 10 months a clinical and laboratory examination was performed and serum samples were tested for three hiv markers: hiv antigen, antibody to p24, and antibody to gp41. twenty-two subjects (23 percent) were found to be positive for hiv antigen: 8 were positiv ...	1987	3477695
uv-induced formation of pyrimidine dimers in nucleosome core dna is strongly modulated with a period of 10.3 bases.	we have determined the distribution of the major uv-induced photoproducts in nucleosome core dna using the 3'----5' exonuclease activity of t4 dna polymerase, which has been shown to stop digestion immediately 3' to uv-induced pyrimidine dimers. this assay is extremely sensitive since all dna fragments without photoproducts (background) are reduced to small oligonucleotides, which can be separated from those fragments containing photoproducts. the results show that the distribution of uv-induced ...	1987	3477794
enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding.	it is proposed that the stability of a protein can be increased by selected amino acid substitutions that decrease the configurational entropy of unfolding. two such substitutions, one of the form xaa----pro and the other of the form gly----xaa, were constructed in bacteriophage t4 lysozyme at sites consistent with the known three-dimensional structure. both substitutions stabilize the protein toward reversible and irreversible thermal denaturation at physiological ph. the substitutions have no ...	1987	3477797
effect of melatonin and 5-methoxytryptamine on sex steroids and thyroid hormones during the prespawning phase of the annual reproductive cycle in the freshwater teleost, clarias batrachus.	melatonin and 5-methoxytryptamine have been studied in the freshwater teleost clarias batrachus during the prespawning period. the data have provided evidence of the inhibitory effects on sex steroids and thyroid hormones when the pineal indoleamines melatonin and 5-methoxytryptamine (5-mt) are administered intramuscularly daily in the afternoon for 27 days. the different dose levels had different effects. the higher dose levels of melatonin showed the initiation of counter inhibitory impacts on ...	1987	3478467
how do eating disorders affect thyroid function?	abnormal thyroid function in patients with eating disorders can result from malnutrition. a low serum triiodothyronine (t3) level is commonly noted in starvation states and is caused by reduced peripheral conversion of thyroxine (t4) to t3. diminished t4 concentrations are also observed. adequate nutrition normalizes this type of aberrant laboratory profile. thyroid function tests that give results below the normal range are best repeated initially for verification of results and again after ade ...	1987	3478668
cloning and expression of t4 dna polymerase.	the structural gene coding for bacteriophage t4 dna polymerase (gene 43) has been cloned into inducible plasmid vectors, which provide a source for obtaining large amounts of this enzyme after induction. the t4 dna polymerase produced in this fashion was purified by an innovative three-step procedure and was fully active.	1987	3478676
serological responses in chimpanzees inoculated with human immunodeficiency virus glycoprotein (gp120) subunit vaccine.	the major envelope glycoprotein of a human immunodeficiency virus (hiv) has been purified and was utilized as a prototype vaccine in chimpanzees. the 120,000-dalton glycoprotein (gp120) was purified from membranes of human t-lymphotropic virus (htlv)-iiib-infected cells and the final preparation contained low levels to no detectable htlv-iiib core antigen (p24) and low levels of endotoxin. chimpanzees inoculated with gp120 responded by developing antibodies that precipitated radiolabeled gp120 a ...	1987	3479807
simian models for aids.	the macaque immunodeficiency syndrome has many parallels to aids in humans. affected monkeys develop profound, prolonged t lymphocyte dysfunction and die of lymphomas or opportunistic infections. we recently isolated a virus that we call siv from four sick macaque monkeys. the morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of human aids. the pathogenicity of this newly isolated virus was tested in macaque monkeys. fiv ...	1987	3480063
immune status of drug abusers.	this study followed 184 drug abusers. examined in all of them were urinary neopterin levels, hbv, sgot, and luestest. seventy-three percent of iv drug addicts showed elevated neopterin levels reflecting activated cellular immunity. statistically, no correlation of neopterin levels with, eg, excessive alcohol consumption, duration of drug abuse, or studied laboratory parameters was found. individuals using cocaine revealed higher neopterin levels than those not doing so. twenty-one of twenty-two ...	1987	3480066
aids and antibodies to human immunodeficiency virus (hiv) in children and their families: clinical experience at yale-new haven hospital.	as of december 1986, we have identified 23 symptomatic children with human immunodeficiency virus (hiv) infection in new haven. twelve developed aids as manifested by lymphocytic interstitial pneumonitis, pneumocystis carinii pneumonia (pcp), and/or disseminated mycobacterial infections; seven of them have died. the remainder have milder clinical syndromes, which include failure to thrive, diffuse lymphadenopathy, and parotid swelling. when compared to adults with aids, children often have hyper ...	1987	3481146
a clinical-immunological evaluation of aids cases and related syndromes.	the clinical features of our cases demonstrated some of the already known characteristics of the variable spectrum of hiv infection. da are the most important risk category in italy. 10% of the arc cases evolved into aids during a 12-month follow-up, on average. the most frequent oi in our aids cases were pcp, c. albicans esophagitis and chronic mucocutaneous ulcers. an high percentage of neurologic involvement from hiv was observed, and malignancies were encountered in aids (3 ks and 1 undiffer ...	1987	3483882
effects of thyroidectomy and thyroxine replacement on the release of luteinizing hormone and gonadotropin-releasing hormone in vitro.	the effects of thyroidectomy and thyroxine (t4) replacement on the release of luteinizing hormone (lh) and gonadotropin-releasing hormone (gnrh) in ovariectomized (ovx) rats were studied. immediately after ovariectomy, rats were thyroidectomized (tx) or sham-tx. the ovx-tx rats were injected subcutaneously with either saline or t4 (2 micrograms/100 g body weight) daily for 30 days before sacrifice. sham-tx rats were treated with saline only. twenty hours after the last injection, the blood sampl ...	1987	3294561
immunoreconstitution of t-cell impairments in asymptomatic male homosexuals by thymic humoral factor (thf).	the feasibility of using thymic humoral factor (thf) for immunomodulation in asymptomatic male homosexuals was evaluated in a study on fifteen subjects with t-cell impairments, selected on the basis of a 2sd reduction in t helper/inducer (t4+) cells and one additional lymphocytic defect. following two biweekly courses of treatment, mean relative increments of t4+ (p less than 0.002), t3+ (p less than 0.02) and total lymphocyte (p less than 0.05) populations of the group receiving thf (n = 7) wer ...	1987	3294619
sequence comparison of single-stranded dna binding proteins and its structural implications.	the primary sequences were compared among several proteins: gene product 5 protein (gp5) from phage m13; pike from phage ike; gene product 32 protein (gp32) from phage t4; reca, ssb and ssf from escherichia coli. these proteins bind strongly and cooperatively to single-stranded dna with no sequence specificity. gp5 is the smallest in this group and its three-dimensional structure is well-characterized. using the entire sequence of gp5 as a template we searched for the regions in other single-str ...	1987	3295261
nucleotide sequence of the deoxycytidylate hydroxymethylase gene of bacteriophage t4 (g42) and the homology of its gene product with thymidylate synthase of e. coli.		1987	3295783
the role of interleukin-2 in proliferative responses in vitro of t cells from patients after bone marrow transplantation. evidence that minor defects can lead to in vitro unresponsiveness.	we have studied lectin-induced interleukin-2 (il-2) production and proliferation of peripheral blood mononuclear cells from patients who had undergone a successful allogeneic bone marrow transplantation. shortly after transplantation, the t cells show a decreased proliferative response and a decreased il-2 production. however, addition to the culture of exogenous il-2 does not result in restoration of the proliferative response, which indicates that the low proliferative response is not due to d ...	1987	3296352
persistent and generalized lymphadenopathy: a lesion of follicular dendritic cells? an immunohistologic and ultrastructural study.	an immunohistochemical and ultrastructural study of 14 cases of persistent and generalized lymphadenopathy (pgl), acquired immune deficiency syndrome (aids) related, revealed florid follicular hyperplasia, follicular dendritic cell (fdc) lysis, lymphoid follicle invaginations, increased presence of t8 cells in germinal center, immature sinus histiocytosis (monocytoid b-cells), and inversion of t4/t8 ratio in the paracortical area. electron microscopic examination showed viral particles of morpho ...	1987	3296738
thermal denaturation of bacteriophage t4 lysozyme at neutral ph.		1987	3297180
fetal and maternal thyroid hormones.	it is well known that insufficient production of thyroid hormones during the fetal and neonatal period of development may result in permanent brain damage unless treatment with thyroid hormone is instituted very soon after birth. but congenital hypothyroidism is not the only situation in which brain damage may be related to insufficient thyroid function. cretinism is the most severe manifestation of iodine deficiency disorders found in areas where iodine intake is greatly reduced. some of the ma ...	1987	3297961
metabolism of the thyroid hormones.	this review covers the current knowledge about the various metabolic pathways involved in the conversion of thyroid hormones to the thyromimetically active and inactive iodothyronines. the concerted mechanism of systemic and local production of iodothyronines by tissue-specific iodothyronine deiodinase isozymes will ultimately determine the expression of thyroid hormone action. this is exemplified for the regulation of synthesis and release of tsh by iodothyronines at the pituitary level. iodoth ...	1987	3297964
the signal sequence of an escherichia coli outer membrane protein can mediate translocation of a not normally secreted protein across the plasma membrane.	the distal part of the long tail fibers of the escherichia coli phage t4 consists of a dimer of protein 37. a fragment of the corresponding gene, encoding 253 amino acids, was inserted into several different sites within the cloned gene for the 325-residue outer membrane protein ompa. in plasmid ptu t4-5 the fragment was inserted once and in ptu t4-10 tandemly twice between the codons for residues 153 and 154 of the ompa protein. in ptu t4-22 two fragments were present, in tandem, between the co ...	1987	3298231
lymphocyte activation in vivo in the intestinal mucosa of patients with crohn's disease.	we analyzed lymphocyte activation state in vivo in lamina propria by applying a panel of monoclonal antibodies for cellular activation markers and by identifying different subsets of 3h-thymidine incorporating lymphoblasts by combining autoradiography with immunoperoxidase staining. in focal lymphoblastoid infiltrates 75 +/- 8% of all inflammatory cells displayed ia, but lymphoid cells expressing 4f2 (40 +/- 6%) and t9 (14 +/- 3%) activation markers were less frequent. the expression of receptor ...	1987	3298655
synthesis and reactivity of intermediates formed in the t4 rna ligase reaction.	the intermediate adenylated donor derivatives a(5')pp(5')dtp and a(5')pp(5')gpgpgp have been prepared from suitable phosphorylating reagents activated by 1-hydroxybenzotriazole. phosphodiester bond formation between donor and acceptor oligonucleotides as catalyzed by t4 rna ligase is shown to be more efficient when the adenylated form of the donor molecule is used.	1987	3299268
assessment of a synthetic dna probe for plasmodium falciparum in african blood specimens.	synthetic dna oligomers homologous to 21-base long repetitive sequences of plasmodium falciparum dna were labeled with 32p using t4 kinase, and were hybridized with purified dna and with processed blood samples from africa. the sequence pfr1, its antiparallel oligomer pfr1r, and pfr1 covalently attached to biotin hybridized similarly to p. falciparum dna. one-microliter aliquots of blood from zaire spotted on prewet nylon filters and hybridized with pfr1 gave detectable autoradiogram signals fro ...	1987	3300392
a probe for the mutagenic activity of the carcinogen 4-aminobiphenyl: synthesis and characterization of an m13mp10 genome containing the major carcinogen-dna adduct at a unique site.	the duplex genome of escherichia coli virus m13mp10 was modified at a unique site to contain n-(deoxyguanosin-8-yl)-4-aminobiphenyl (dg8-abp), the major carcinogen-dna adduct of the human bladder carcinogen 4-aminobiphenyl. a tetradeoxynucleotide containing a single dg8-abp residue was synthesized by reacting 5'-d(tpgpcpa)-3' with n-acetoxy-n-(trifluoracetyl)-4-aminobiphenyl, followed by high-performance liquid chromatography purification of the principal reaction product 5'-d(tpg8-abppcpa)-3' ( ...	1987	3300770
the in vivo stability, maturation and aminoacylation of anticodon-substituted escherichia coli initiator methionine trnas.	we have constructed eight anticodon-modified escherichia coli initiator methionine (fmet) trnas by insertion of synthetic ribotrinucleotides between two fragments ('half molecules') derived from the initiator trna. the trinucleotides, namely cau (the normal anticodon), caa, cac, cag, gaa, gac, gag and gau, were joined to the 5' and 3' trna fragments with t4 rna ligase. the strategy of reconstruction permitted the insertion of radioactive 32p label between nucleotides 36 and 37. trnas were microi ...	1987	3301339
failure of misonidazole-sensitized radiotherapy to impact upon outcome among stage iii-iv squamous cancers of the head and neck.	as part of the rtog research effort in the treatment of advanced, inoperable squamous cancer of the head and neck region, the hypoxic cell sensitizer, misonidazole, was selected for investigation as an adjuvant to definitive irradiation. based upon a pilot experience (78-02) showing a 67% complete response rate among 36 ajc stage iii-iv patients receiving full-dose irradiation and 6 weekly p.o. doses of misonidazole, a phase iii trial was carried out from '79-'83. three hundred and six patients ...	1987	3301758
effects of various single-stranded-dna-binding proteins on reactions promoted by reca protein.	to relate the roles of escherichia coli ssb in recombination in vivo and in vitro, we have studied the mutant proteins ssb-1 and ssb-113, the variant ssbc produced by chymotryptic cleavage, the partially homologous variant f ssb (encoded by the e. coli sex factor), and the protein encoded by gene 32 of bacteriophage t4. all of these, with the exception of ssb-1, augmented both the initial rate of homologous pairing and strand exchange promoted by reca protein. from these and related observations ...	1987	3301800
t-even-type bacteriophages use an adhesin for recognition of cellular receptors.	protein 38 of the escherichia coli phage t4 is thought to be required catalytically for the assembly of the long tail fibers of this phage. it is shown that this protein of phage t2 and the t-even-type phage k3 and ox2 act differently. it was found that nh2-terminal fragments of the protein, expressed from cloned fragments of gene 38 of phage k3, bind to gene 38 amber mutants of phage t2. such phage or t2 gene 38 amber mutants, grown on a non-permissive host, possess a complete set of six tail f ...	1987	3302275
[immunotherapy of terminal-stage malignant tumors with the immunopotentiator ok-432--a comparison between su-ps test-responder and -nonresponder patients].	we treated terminal malignant tumor cases with the immunopotentiator ok-432 and determined the absolute numbers of neutrocytes, lymphocytes, and lymphocyte subpopulations, carrying out the su-ps and ppd skin tests. after the start of therapy, su-ps test changed to positive in one-third of the patients. the su-ps -responder patients showed an increase in lymphocytes and leu 11a-positive cells, and an elevation of the ok t4/t8 ratio two weeks later. in the su-ps-nonresponder group, okt4-positive c ...	1987	3302349
nonsense suppression context effects in escherichia coli bacteriophage t4.	nonsense suppression by supe44 has been examined in a collection of 14 t4 gene 22 and gene 23 uag mutants, for which the precise gene location is known. in concordance with previous studies, uag followed by a pyrimidine was inefficiently suppressed. however, among positions with similar 3' nucleotides, there was considerable variation in suppression efficiency. the competition between supe44 and release factor 1 (rf 1) was also investigated following the introduction of a multicopy rf 1 plasmid. ...	1987	3302602
high-frequency spontaneous deletion of dna sequences flanked by direct dna repeats which also contain an internal palindrome.	the dna sequences associated with a very high-frequency, spontaneous deletion event have been determined to be two 11-base direct repeats which also contain an internal 6-base palindrome. a parental m13 replicative form (rf) dna harboring dna fragments of the t4 denv gene contained these direct repeats and could only be maintained at 5% of the total rf dna within an infected cell. the remaining rf dna was deleted for all intervening sequences between the direct repeats (2.2-kb), but one copy of ...	1987	3302689
modulation of chronic lymphocytic leukemia (cll) lymphocyte phenotypes by in vitro incubation with alpha 1 thymosin.	in this study an attempt was made to elucidate (1) the level(s) of differentiation arrest of b cells, and (2) whether t-cell functional defects in cll patients are related to their defective maturation. in addition, an attempt was also made to induce and/or correct maturation of t cells in cll patients by in vitro incubation with alpha 1 thymosin. in cll patients and controls, we determined the percentage of t and b cells with t11, t8, t4, c3, and mouse erythrocyte (me) receptors, along with t-c ...	1987	3304472
changes in rectal leucocytes after allogeneic bone marrow transplantation.	using immunohistological techniques the number of leucocytes present in the epithelium and lamina propria of the rectal mucosa were assessed in 16 allogeneic bone marrow transplant recipients, with and without evidence of graft-versus-host disease (gvhd), and compared with a non-transplant group of patients. samples were obtained between 15 and 198 days after transplant. in marrow recipients without gvhd, compared with non-transplant cases, there was a decrease in t lymphocytes in the lamina pro ...	1987	3304737
single-dose response kinetics of cyclosporine.	cyclosporine (cy) dose-response kinetics were studied in 8 renal failure patients awaiting kidney transplantation. all patients received a single oral dose of cy (7 mg/kg). blood samples were drawn frequently before and until 4 days after cy administration. cy blood levels were measured by radioimmunoassay (ria). okt3-induced in vitro proliferation of simultaneously isolated lymphocytes was determined by h3-thymidine incorporation. t cell subpopulations were enumerated using a peroxidase-antiper ...	1987	3304744
monitoring of immunological parameters before and after heart transplantation.	at the immunological examinations carried out prior to heart transplantation, it is crucial to check the compatibility in the abo blood group system (regardless of the rh factor) and to perform the cross match (which must be negative). in time pressure, cross match can be omitted provided the patient does not possess cytotoxic antibodies against a representative panel of lymphocytes. other immunological tests before transplantation are of an auxiliary nature and should provide information whethe ...	1987	3304835
glucose and insulin reverse the effects of fasting on 3,5,3'-triiodothyronine neogenesis in primary cultures of rat hepatocytes.	the cellular mechanisms by which carbohydrate refeeding reverses the effect of fasting on t3 metabolism were studied in primary cultures of hepatocytes (24 h) harvested from 48-h fasted rats. net t3 neogenesis (t3 generated from t4) in the fasted hepatocyte preparations (9.2 +/- 0.9 pmol/min x 100 mg protein) was significantly less (p less than 0.001) than that in hepatocyte cultures derived from 72-h glucose-fed rats (41 +/- 0.8 pmol/min x 100 mg protein). preincubation (18 h) with either gluco ...	1987	3304981
evidence for an activated subpopulation of t8-bearing cells in male homosexuals with lymphadenopathy.	data are presented that male homosexuals with chronic lymphadenopathy and reduced numbers of t4-antigen-bearing cells have an increased incidence of activated t8-antigen-bearing cells. evidence suggesting an increase in activated t cells in these subjects includes an increase in incidence of t10-antigen-bearing cells, an increase in ia-bearing t cells and an increase in the intensity of staining of a fraction of the t8-antigen-bearing cells with fluorescein-labeled okt8 monoclonal antibody. it w ...	1987	3305374
interactions of the bacteriophage t4 gene 55 product with escherichia coli rna polymerase. competition with escherichia coli sigma 70 and release from late t4 transcription complexes following initiation.	the bacteriophage t4 gene 55 protein endows escherichia coli rna polymerase core with the ability to recognize t4 late promoters. in these experiments, we show that t4 gene product (gp) 55, like the major e. coli rna polymerase initiation subunit sigma 70, is released from elongating transcription complexes and is thus capable of cycling among molecules of rna polymerase core. we also show that, paradoxically, sigma 70 is able to displace t4 gp55 from its site of binding to e. coli rna polymeras ...	1987	3305506
expression of class ii major histocompatibility complex antigens on alveolar epithelium in interstitial lung disease: relevance to pathogenesis of idiopathic pulmonary fibrosis.	to determine whether expression of class ii major histocompatibility complex antigens on alveolar epithelium is relevant to the pathogenesis of idiopathic pulmonary fibrosis (ipf) lung biopsy specimens were investigated from nine patients with ipf with or without connective tissue disease, four patients with sarcoidosis, eight patients with lung disease of presumably infectious origin, and five controls. the alveolar epithelium stained strongly with anti-ia (hla-dr) or leu 10 (hla-ds) monoclonal ...	1987	3305583
possible mechanisms involved in the immunoregulation of chronic inflammatory periodontal disease.	it is generally agreed that immunological mechanisms are involved in the pathogenesis of periodontal disease; however, regulation of these mechanisms has hitherto received scant attention. regulatory networks exist at both a cellular and a molecular level. at the cellular level, the existence of helper (t4-positive) and suppressor (t8-positive) t lymphocytes, the expression of class ii major histocompatibility complex antigens, and the heterogeneity of macrophage subpopulations are central to an ...	1987	3305617
initial treatment of thyrotoxic graves' disease with methimazole: a randomized trial comparing different dosages.	we evaluated the efficacy of different doses of methimazole (mmi) as the initial therapy for graves' disease. fourteen patients were treated with 15 mg/die of the drug (group a) and 14 with 30 mg/die (group b). blood samples for t3, t4, ft3 and ft4 were obtained before beginning therapy, every 48 h during the first 12 days and on the 45th day of treatment. all these hormonal parameters fell significantly from the 2nd day of therapy in both groups. all the patients, except for one in group b, had ...	1987	3305681
early stages of synthesis of thyroglobulin (tg), thyroxine (t4), and triiodothyronine (t3) in fetal rat thyroid. an immunoelectron microscopic study.	immunoelectron microscopy was applied for detection of tg, t4, and t3 in fetal rat thyroid gland during the early stages of synthesis of these compounds, in order to elucidate the subcellular aspects of onset of their production. tg was detected in the perinuclear space, rer, and golgi apparatus as early as the sixteenth day of gestation when no follicles had yet formed. when primitive follicles had formed after the seventeenth day of gestation, both t4 and t3, as well as tg, appeared on the sur ...	1987	3305703
circumsporozoite gene of a plasmodium falciparum strain from thailand.	the nucleotide and deduced amino acid sequences of the cs gene of a plasmodium falciparum strain from thailand (t4) are presented. comparison with the nucleotide sequences of two other p. falciparum cs genes, 7g8 from brazil and wellcome from west africa, shows that: the coding regions outside the repeats of t4 and 7g8 are co-extensive and lack 30 nucleotides present in the wellcome strain 5' to the repeats; in this region, t4 also differs at 3 nucleotide positions from the 7g8 and the wellcome ...	1987	3306373
hl-t, a new cell line derived from hl-60 promyelocytic leukemia cell cultures expressing terminal transferase and secreting suppressor activity.	a cell line with immature blast cell morphology was isolated from hl-60 promyelocytic leukemia cell cultures and designated hl-t. this new cell type is biphenotypic, expressing terminal transferase (tdt) together with myelomonocytoid immunologic features. tdt enzymatic activity, undetectable in hl-60, was determined to be 140 to 180 units/10(8) hl-t cells by the dgtp-assay, approximately 20% of the activity found in lymphoblastoid cell lines. hl-t predominantly synthesize the known 58-kda tdt-pr ...	1987	3307949
prognostic significance of the expression of a ras protein with a molecular weight of 21,000 by human breast cancer.	expression of the cellular ras mr 21,000 protein (p21) has been measured in tumors from breast cancer patients who at time of presentation had no evidence of metastatic disease. western blotting analysis revealed that 37 of 54 (69%) tumors contained p21 levels 2- to 10-fold greater than those of control breast tissues. an excessive increase of p21 (5- to 10-fold over the control value) occurred more frequently in tumors of t3 and t4 stages [15 of 25 (60%)] than in tumors at t2 stage [6 of 29 (21 ...	1987	3308076
thyroid function in leukaemia patients after allogeneic bone marrow transplantation.	the thyroid function of 29 patients who underwent allogeneic bone marrow transplantation preceded by total body irradiation was followed closely during four weeks after transplantation. twenty patients showed a marked decrease of t3 and tsh levels, whereas t4 fluctuated. long-term follow up from three to five years of the surviving 16 patients revealed a restoration of the t3 levels to normal, a slight increase in t4 levels and a doubling of the tsh levels. this indicates the necessity of a high ...	1987	3308179
determinants of thyroid volume as measured by ultrasonography in healthy adults in a non-iodine deficient area.	thyroid volume was measured by ultrasonography in 50 healthy adults (25 males, 25 females, age 20-70 years) living in the non-iodine deficient area of amsterdam. thyroid volume was 10.7 +/- 4.6 ml (mean +/- sd, range 2.7-20.4 ml). no relation was found between thyroid volume and any of the following parameters: plasma tsh, t4, t3, thyroglobulin (tg), urinary iodine excretion, tobacco and alcohol consumption. thyroid volume in males (12.7 +/- 4.4 ml) was greater than in females (8.7 +/- 3.9 ml, p ...	1987	3308184
malaria specific human t cell clones: crossreactivity with various plasmodia species.	peripheral blood mononuclear cells (pbmc) from donors with or without previous exposure to malaria in vivo were cultivated for 4 to 7 days in the presence of different malaria antigen (m.ag) preparations: plasmodium falciparum (p.f.ag), p. berghei (p.b.ag) and p. gallinaceum (p.g.ag). all preparations induced a proliferative response in pbmc from donors with or without previous exposure to malaria. pbmc from both groups of donors were then primed with each of the three m.ag and cloned in presenc ...	1987	3308225
ontogeny of ovine lymphocytes. ii. an immunohistological study on the development of t lymphocytes in the sheep fetal spleen.	the development of t and b lymphocytes in the ovine fetal spleen was studied immunohistologically using a panel of monoclonal antibodies. a specific sequence of appearance of lymphocyte markers on cells was observed. at 43-44 days of gestation, sbu-t1- and sbu-t8-positive lymphocytes were present in low numbers. however, no sbu-t4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes were seen until 50-55 days of gestation. surface immunoglobulin (sig) was first detected on fetal spleen cells a ...	1987	3308689
ontogeny of ovine lymphocytes. iii. an immunohistological study on the development of t lymphocytes in sheep fetal lymph nodes.	the development of t lymphocytes in ovine fetal lymph nodes was studied immunohistologically using a panel of monoclonal antibodies. t lymphocyte subsets appeared within the ovine fetal lymph node in a specific sequence. sbu-t1- and sbu-t8-positive lymphocytes were seen at day 47 of gestation. lca, sig, mhc i, mhc ii, sbu-t6 and 46.66 antigens were also seen within the lymph node at this time. the first sbu-t4-positive cells were seen within the fetal lymph node at day 50 of gestation, along wit ...	1987	3308690
ontogeny of ovine lymphocytes. i. an immunohistological study on the development of t lymphocytes in the sheep embryo and fetal thymus.	the time of appearance of lymphocytes expressing t-cell markers and the subsequent development of the fetal thymus were studied in ovine embryos using a panel of monoclonal antibodies. leucocyte common antigen (lca) and major histocompatibility complex class i (mhci) antigens were seen on a small number of cells within the ovine embryo at day 19 of gestation. sbu-t6 (cd1)-positive cells were found at day 22 of gestation, while major histocompatibility complex class ii (mhc ii) antigens were firs ...	1987	3308692
the conformation of t4 bacteriophage dihydrofolate reductase from circular dichroism.	the secondary and tertiary structure of t4 bacteriophage dihydrofolate reductase is investigated by vacuum ultraviolet circular dichroism (cd) spectroscopy and probability analysis of the primary amino acid sequence. the far ultraviolet cd spectrum of the enzyme in the range of 260-178 nm is analyzed by the generalized inverse and variable selection methods developed by our laboratory. variable selection yields an average content of 26% alpha-helix, 21% antiparallel beta-sheet, 10% parallel beta ...	1987	3308867
[hormonal findings in obese children. a review].	serum thyroid hormones in childhood obesity are not altered but caloric intake affects monoiodination of t4 to t3 and rt3. plasma cortisol and urinary free cortisol concentrations are normal. increase in cortisol production and secretion rate is reflected in increased values of urinary 17-hydroxycorticosteroids. elevated urinary 17-ketosteroids are caused by increased androgen synthesis accounting for the increased height velocity in obese preadolescents and for the accelerated skeletal maturati ...	1987	3309453
temperature sensitivity of the multiplication of bacteriophage t4 amber mutants on nonpermissive host: characterization of the phenomenon.	the existence of temperature sensitivity of the multiplication of amber mutants on a nonpermissive host has been established for a considerable number of mutants in tail and head genes and for mutants in some other t4 genes as well. temperature sensitivity of multiplication appears to be gene specific, and is typical of amber mutants in genes the products of which are not numerous per phage or which play the role of catalytic factor. moreover, in most cases temperature sensitivity is characteris ...	1987	3310383
thyroid hormone binding and deiodination by pancreatic islets: relationship with the in vitro effect upon insulin secretion.	thyroxine dehalogenation by rat pancreatic islets was studied incubating isolated islets with labelled t4. [125i]t4 added to the incubation medium was deiodinated by the islets with the consequent production of t3, rt3 and iodide. this deiodination process showed a clear glucose-dependence, being significantly increased in the presence of 16.6 mmol/l glucose. the existence of high and low affinity binding sites for t3 was also demonstrated incubating [125i]t3 with islets under different experime ...	1987	3310493
a raman spectroscopic study of the interaction between nucleotides and the dna binding protein gp32 of bacteriophage t4.		1987	3311188
[serological and immunological diagnosis of hiv-1 infection. studies of 198 infected cases].	since 1985, a total of 4281 patients at the department of dermatology, university of munich, were tested for hiv-1 antibodies. using the elisa test, 273 were found to be positive, of whom 198 were examined clinically. at the time of the first serological test, 76 of these 198 patients (38.4%) had no clinical symptoms, 98 (49.5%) had a lymphadenopathy syndrome, and 29 had the full-blown picture of aids (12.1%). the following additional tests were performed on the 198 patients: antibodies against ...	1987	3311695
recombinant human interleukin-2 restores in vitro t-cell colony formation by peripheral blood mononuclear cells after autologous bone marrow transplantation.	immune reconstitution after autologous bone marrow transplantation (abmt) was studied in peripheral blood by phytohemagglutinin stimulated t-cell colony formation (cfu-tl) and by surface phenotype analysis of t-lymphocytes with monoclonal antibodies. twenty-six patients (15 small-cell lung cancer, 5 lymphoma, 3 acute myeloid leukemia [aml], 2 germ cell cancer, and 1 melanoma) were conditioned with high-dose multiple drug combinations (plus total body irradiation in aml patients). no maintenance ...	1987	3311785
seasonal variation in thyroid size in healthy males.	thyroid volume, measured ultrasonically, and serum levels of t4, t3 and tsh were determined every season during one year in 13 healthy males. a mean variation in thyroid volume of approximately 23% between minimum values (15.8 +/- 1.7 ml, summer) and maximum values (19.5 +/- 1.9 ml, winter) was found (p less than 0.01), although no significant differences in the other thyroid variables could be demonstrated. this seasonal variation in thyroid size should be taken into account when goitre frequen ...	1987	3311957
hormonal changes in haemodialysed and in kidney-transplanted patients.	a total of 48 haemodialysed patients were studied by radioimmunoassay for the serum concentrations of parathormone, calcitonin, gastrin, insulin, prolactin, t3, t4, rt3, tsh and cortisol. residual urines were measured for camp and ultrafiltrates for ipth and gastrin. the duration of the dialysis programme, the number of haemodialysis sessions per week, sex distribution, the dialysis alternatives (including haemofiltration, haemoperfusion) and successful kidney transplantations were correlated wi ...	1987	3312062