Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| t4 endonuclease v promotes the formation of multimeric dna structures. | electron microscopy of uv-irradiated circular dna molecules which had been treated with t4 endonuclease v revealed the formation of multimeric dna structures in addition to the expected conversion of the superhelical dna molecules into nicked circular and linear forms. the multimeric dna molecules could be distinguished in electron micrographs from catenated molecules which were present in the original dna preparation by a combination of rotary and single angle heavy metal shadowing. the complex ... | 1987 | 3547103 |
| purification of the t4 endonuclease v. | a new purification protocol has been developed for the rapid isolation to physical homogeneity of t4 endonuclease v. the enzyme was purified from an escherichia coli strain which harbors a plasmid containing the t4 denv structural gene downstream of the lambda rightward promoter. the purification of the enzyme was monitored by pyrimidine dimer-specific nicking activity, western blot analysis and silver or coomassie blue staining of sds-polyacrylamide gels. milligram quantities of the enzyme have ... | 1987 | 3547104 |
| effects of maternal oral salbutamol therapy on neonatal endocrine status at birth. | cord blood concentrations of insulin, growth hormone (gh), triiodothyronine (t3), thyroxine (t4), and thyroid-stimulating hormone (tsh) from 20 patients treated with oral salbutamol were compared with those of 18 matched patients who had not received any betamimetic agents. no significant difference was found in circulating insulin, t3, t4, and tsh between both groups. however, gh levels were significantly higher in the treated group (36.5 +/- 17.4 ng/ml) than in the control group (17.4 +/- 6.6 ... | 1987 | 3547214 |
| utilization of dna photolyase, pyrimidine dimer endonucleases, and alkali hydrolysis in the analysis of aberrant abc excinuclease incisions adjacent to uv-induced dna photoproducts. | abc excinuclease of escherichia coli removes 6-4 photoproducts and pyrimidine dimers from dna by making two single strand incisions, one 8 phosphodiester bonds 5' and another 4 or 5 phosphodiester bonds 3' to the lesion. we describe in this communication a method, which utilizes dna photolyase from e. coli, pyrimidine dimer endonucleases from m. luteus and bacteriophage t4, and alkali hydrolysis, for analyzing the abc excinuclease incision pattern corresponding to each of these photoproducts in ... | 1987 | 3547334 |
| lack of response to suramin in patients with aids and aids-related complex. | forty-one homosexual men with the acquired immune deficiency syndrome (aids) or aids-related complex were treated with 0.5, 1.0, or 1.5 g of suramin weekly for up to six months. in no patient was evidence of symptomatic improvement or regression of kaposi's sarcoma shown. opportunistic infections developed in 16 patients during therapy. only six patients (15 percent) became human immunodeficiency virus (hiv) culture-negative during treatment, despite documentation of adequate serum suramin level ... | 1987 | 3548350 |
| subarachnoid analgesia for caesarean section. a double-blind comparison of plain and hyperbaric 0.5% bupivacaine. | equal volumes (2.5 ml, 12.5 mg) of plain 0.5% bupivacaine (glucose-free) and hyperbaric 0.5% bupivacaine (in 8% glucose) were compared in a randomized double-blind study of 40 patients undergoing caesarean section under subarachnoid anaesthesia. there were no differences in the rate of onset, maximum spread, number of patients with high cervical levels, duration of anaesthesia or incidence of post-spinal headaches between the two solutions. the median maximum cephalad levels of analgesia were (h ... | 1987 | 3548793 |
| molecular characterisation of the dna ligase gene, cdc17, from the fission yeast schizosaccharomyces pombe. | we have sequenced a 4200-base-pair fragment of schizosaccharomyces pombe dna which encompasses the entire dna ligase gene, cdc17. s1 mapping has enabled us to identify two small introns (40 and 62 nucleotides) at the 5' end of the coding region of the gene and their 3' internal conserved sequences match the ctray consensus found in other s. pombe introns. the major transcription initiation and 3' polyadenylation sites have been mapped and are preceded by higher eukaryotic-like tata and aataaa se ... | 1987 | 3549293 |
| circulating prostacyclin and thromboxane in patients with graves' disease. | we measured plasma levels of pgi2 as 6-keto-prostaglandin f1 alpha (6-keto-pgf1 alpha) and thromboxane a2 (txa2) as thromboxane b2 (txb2) in patients with graves' disease and in normal subjects. the levels of plasma 6-keto-pgf1 alpha were significantly elevated and correlated with those of serum t4 and t3, respectively, in hyperthyroid patients with graves' disease. significant reduction of 6-keto-pgf1 alpha levels was observed after antithyroid drug therapy. in contrast, the levels of plasma tx ... | 1987 | 3543972 |
| "plasmacytoid t cells" in castleman's disease. immunohistologic phenotype. | plasmacytoid t cells in two cases of castleman's disease were stained with a panel of monoclonal antibodies to hematopoietic cell-associated antigens, using an immunoperoxidase technique on frozen sections. the immunohistologic phenotype of these cells was t4/leu-3+, hla-dr+, t1/leu-1-, t3/leu-4-, t8/leu-2-, t11/leu-5-, b1-, b2-, leu-14-, ig-, calla-, okm1-, leu-m1-. in contrast to plasma cells of b lineage, plasmacytoid t cells were t200+, t10-. the phenotype was similar to that of two previous ... | 1987 | 3544885 |
| lymphocyte subsets in tumour of patients with undifferentiated nasopharyngeal carcinoma: presence of lymphocytes with the phenotype of activated t cells. | we have analyzed lymphocytes infiltrating nasopharyngeal carcinomas, using a combination of immunoperoxidase staining of frozen and paraffin-embedded sections, and immunofluorescence on lymphocyte suspensions recovered from teased tumours. a panel of monoclonal antibodies was used to define lymphocytic subsets on frozen sections of 14 different tumours. the vast majority of peri- and intra-tumoral lymphocytes were stained by okt3 antibody. in 8 sections, t4 positive cells were largely predominan ... | 1987 | 3545275 |
| cloning and characterization of the escherichia coli lit gene, which blocks bacteriophage t4 late gene expression. | escherichia coli lit mutations inhibit gene expression late in infection by bacteriophage t4. we cloned the lit gene from wild-type e. coli and three independent lit mutants. we present evidence that lit mutations [renamed lit(con) mutations] cause overproduction of the lit gene product and that overproduction of this product causes the inhibition of gene expression. we also present evidence that the lit gene product is nonessential for e. coli growth, although the gene is common to most e. coli ... | 1987 | 3546267 |
| increased plasma gonadotropin levels in spontaneous hyperthyroidism reproduced by thyroxine but not by triiodothyronine administration to normal subjects. | in nine hyperthyroid women studied in the follicular phase of the menstrual cycle basal plasma lh concentrations and lh and fsh responses to gnrh were increased compared to those in nine normal women. the increased gonadotropin levels could not be related to changes in body weight or plasma estradiol or serum sex hormone-binding globulin levels, and they approached normal levels during or after treatment of hyperthyroidism. when normal women were treated with t4 (0.5 mg daily for 6-10 days), the ... | 1987 | 3546351 |
| abortive infection by bacteriophage me1 of escherichia coli k12 strains bearing the plasmid colv, i-k94. | bacteriophage me1 is unable to grow on escherichia coli strains harbouring the colv,i-k94 plasmid. the nature of this inhibition was investigated, and it was found not to be due to restriction, superinfection exclusion or receptor-mediated resistance, but to be a new example of plasmid-mediated abortive infection. investigation of events occurring during abortive me1 infection revealed some differences from previously described cases, especially with regard to late protein synthesis, which did o ... | 1987 | 3546592 |
| production and metabolic clearance of angiotensinogen in conscious rats as measured by steady-state isotope dilution. | previous studies on the hormonal regulation of hepatic angiotensinogen relied on in-vitro liver preparations and on the measurement of changes in plasma concentration. in this study 125i-labelled angiotensinogen was used to measure simultaneously the production rate (pr) and metabolic clearance rate (mcr) in conscious rats by the constant-rate infusion and single-injection methods. male rats received daily s.c. injections of isotonic saline (as control), 1 mg corticosterone acetate (ca), 25 micr ... | 1987 | 3549956 |
| in vitro construction of yeast trnaasp variants: nucleotide substitutions and additions in t-stem and t-loop. | a procedure for the construction of 3'-end labelled yeast trnaasp harboring substitutions or additions of any desired nucleotide in t-stem and t-loop (position 57 to 61) has been developed. this was done by in vitro enzymatic manipulations of the yeast trnaasp involving specific hydrolysis with rnases, phosphorylation and dephosphorylation with t4 polynucleotide kinase and ligation with t4 rna ligase. using this procedure we have replaced conserved or semi-conserved nucleotides located in positi ... | 1987 | 3550694 |
| purification and characterization of 3-methyladenine dna glycosylase i from escherichia coli. | we have purified 3-methyladenine dna glycosylase i from escherichia coli to apparent physical homogeneity. the enzyme preparation produced a single band of mr 22,500 upon sodium dodecyl sulphate/polyacrylamide gel electrophoresis in good agreement with the molecular weight deduced from the nucleotide sequence of the tag gene (steinum, a.-l. and seeberg, e. (1986) nucl. acids res. 14, 3763-3772). hplc confirmed that the only detectable alkylation product released from (3h)dimethyl sulphate treate ... | 1987 | 3550703 |
| macromolecular crowding increases binding of dna polymerase to dna: an adaptive effect. | macromolecular crowding extends the range of ionic conditions supporting high dna polymerase reaction rates. reactions tested were nick-translation and gap-filling by dna polymerase i of escherichia coli, nuclease and polymerase activities of the large fragment of that polymerase, and polymerization by the t4 dna polymerase. for all of these reactions, high concentrations of nonspecific polymers increased enzymatic activity under otherwise inhibitory conditions resulting from relatively high ion ... | 1987 | 3550799 |
| activation marker analysis of mononuclear cell infiltrates of oral lichen planus in situ. | monoclonal activation markers (ia, tac, t9, and 4f2) were used to detect the degree of activation of mononuclear cells in the inflammatory infiltrates of oral lichen planus in situ. in addition the specimens were stained with the following monoclonal antibodies: t4, t8, t11, m1, and pan-b. t-lymphocyte was the predominant cell type in the inflammatory infiltrates. according to the results of the activation marker analysis, the majority of the t-lymphocytes were resting. however, activated cytoto ... | 1987 | 3551045 |
| current management of the patient with autonomously functioning nodular goiter. | autonomously functioning thyroid nodules (aftns) are presumably independent of tsh for growth and function and appear "hot" on scintiscan because they selectively concentrate radionuclide to a greater extent than the remaining thyroid gland, which is controlled by the normal th-tsh feedback mechanism. such autonomously functioning tissue may occur in "patchy" areas, as a solitary nodule, or as multiple nodules (classic plummer's disease), with the mass of hyperfunctioning tissue and the related ... | 1987 | 3551148 |
| diabetes decreases liver and kidney nuclear 3,5,3'-triiodothyronine receptors in rats. | the liver and kidney nuclear t3 content and the maximal nuclear t3-binding capacity (mbc) were measured 1 month after streptozotocin administration and compared with values in controls either fed ad libitum (c) or offered a restricted diet (fr). a group of insulin-treated diabetic (d+i) rats was also included. plasma t4 and t3 concentrations decreased to low levels in diabetic (d) rats. plasma t3 levels were decreased in fr rats, whereas circulating t4 was in the normal range for c animals. the ... | 1987 | 3552632 |
| genetic mapping of the amino-terminal domain of bacteriophage t4 dna polymerase. | the dna polymerase of bacteriophage t4 is a multifunctional enzyme that harbors dna-binding, dna-synthesizing and exonucleolytic activities. we have cloned in bacterial plasmids about 99% of the structural gene for this enzyme (t4 gene 43). the gene was cloned in six contiguous 5'-terminal dna fragments that defined seven intragenic mapping regions. escherichia coli hosts harboring recombinant plasmids carrying the gene 43 subsegments were used in marker-rescue experiments that assigned a large ... | 1987 | 3552871 |
| a new epistasis group for the repair of dna damage in bacteriophage t4: replication repair. | the gene 32 mutation ama453 sensitizes bacteriophage t4 to the lethal effects of ultraviolet (uv) irradiation, methyl methanesulfonate and angelicin-mediated photodynamic irradiation when treated particles are plated on amber-suppressing host cells. the increased uv sensitivity caused by ama453 is additive to that caused by mutations in both the t4 excision repair (denv) and recombination repair (uvswxy) systems, suggesting the operation of a third kind of repair system. the mutation uvs79, with ... | 1987 | 3552872 |
| imbalanced deoxyribonucleoside triphosphate pools and spontaneous mutation rates determined during dcmp deaminase-defective bacteriophage t4 infections. | dna precursor imbalances are known to be mutagenic in both eukaryotic and prokaryotic systems. almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. since other factors may be involved, it is important to identify specific mutations induced by specific pool imbalances. using bacteriophage t4, we have developed a system for such analysis. we prepare double mutants of t4; one mutation affects a phage-coded enzyme of d ... | 1987 | 3553179 |
| relationship between the integrity of bowman's capsule and the composition of cellular crescents in human crescentic glomerulonephritis. | cell constituents of glomerular crescents still remain controversial. we examined cellular crescents in ten cases of crescentic glomerulonephritis (gn) using indirect immunoperoxidase technique and monoclonal antibodies against t cells (okt3) and subsets: t helper/inducer cell (t4), t suppressor/cytotoxic cell (okt8), t activated cell (iot14 and iot15); b cells (b1, b4, okb2 and iob3) and subsets (b2 and iob1); monocytes/macrophages (leum3); dr ag (i2) and renal native cells: podocytes (iot5), b ... | 1987 | 3553736 |
| the bacteriophage t4 dexa gene: sequence and analysis of a gene conditionally required for dna replication. | we have cloned and sequenced a bacteriophage t4 ecori fragment that complements t4 del (39-56) infections of an opta defective escherichia coli strain. bacteria containing this recombinant plasmid synthesize two new proteins with molecular weights of 9 and 26 kilodaltons. we have identified the gene encoding the 26 kilodalton protein as essential for t4 infections of opta defective e. coli. genetic and biochemical results are consistent with the identification of this protein as the product of t ... | 1987 | 3553862 |
| cobalt-protoporphyrin suppresses thyroid and testicular hormone concentrations in rat serum: a novel action of this synthetic heme analogue. | treatment of rats with co-protoporphyrin, a synthetic metalloporphyrin which produces a marked and sustained induction of hepatic heme oxygenase and decline in cellular cytochrome p-450 content, caused a significant reduction in serum testosterone, serum thyroxine (t4) and 3,5,3'-triiodothyronine (t3) levels. these endocrine changes were not accompanied by reciprocal elevations in either serum luteinizing hormone (lh) or thyroid-stimulating hormone (tsh) concentrations. seminal vesicles from co- ... | 1987 | 3554276 |
| [post-traumatic/postoperative immune deficiency syndrome]. | severe trauma, major surgery and burns (tsb) are often followed by infections, adult respiratory distress syndrome and multi-organ failure, complications which are thought to be the consequence of the post-tsb immunodeficiency syndrome. the most important data and hypotheses in this regard are summarized. after a tsb event large amounts of tissue debris, endotoxins and microorganisms have to be eliminated. further important factors in tsb are stress reactions, malnutrition, loss and replacement ... | 1987 | 3554499 |
| a prospective study of thymopentin in severely burned patients. | a randomized prospective double-blind study of thymopentin was performed upon 24 severely burned patients to evaluate its efficacy in correcting postburn immunologic abnormalities and preventing infectious morbidity and mortality. patients in the treated group received 50 milligrams of thymopentin daily for the first two weeks after injury and three times weekly thereafter until the patient was no longer at risk for having infections develop. the placebo group received saline solution intravenou ... | 1987 | 3554564 |
| phenotyping of proliferating lymphocytes in angioimmunoblastic lymphadenopathy and related lesions by the double immunoenzymatic staining technique. | biopsy specimens of lymph nodes with the histologic characteristics of angioimmunoblastic lymphadenopathy with dysproteinemia (aild) were obtained from 9 cases (4 cases of aild and 5 cases of aild-like t lymphoma [aild-t]) and histologically analyzed by the use of a double immunoenzymatic staining technique with the combination of a monoclonal antibody against lymphocyte membrane antigen and that against human dna polymerase alpha (pol alpha), which is detectable in the nucleus of the cells in g ... | 1987 | 3555102 |
| immunoultrastructural studies of human nk cells: i. ultracytochemistry and comparison with t cell subsets. | human nk activity is known to be associated with a population of large granular lymphocytes (lgl) exhibiting several immunophenotypic surface markers including leu-11a (nkp-15), leu-7 (hnk-1), leu-3a (t4), and leu-2a (t8). based upon correlation with cytolytic activity, leu-11a is now considered the most specific antigenic marker for human nk cells. present investigation compared the ultrastructure of cells expressing leu-11a, leu-7, leu-3a, and leu-2a, both in human peripheral blood lymphocytes ... | 1987 | 3555161 |
| class ii antigen expression and inflammatory cells in the guillain-barré syndrome. | monoclonal antibodies to t-lymphocyte subsets and class ii molecules (ia) have been used to characterize the inflammatory infiltrate in nerve tissue biopsied from 2 patients in the acute phase of guillain-barré syndrome; the findings were compared with those in control nerve specimens. normal control nerve was treated in the same way. in normal nerves, class ii molecules are expressed on endothelial cells and on occasional mononuclear and perineurial cells. in guillain-barré nerves the inflammat ... | 1987 | 3555282 |
| [results of an interdisciplinary study of primary inoperable stage t3 and t4 squamous cell carcinoma of the mouth, oropharynx and hypopharynx]. | from dec. 1980 to may 1984 26 patients with inoperable carcinomas of oral cavity, oropharynx and hypopharynx, were treated by us by a primary systemic chemotherapy. at all there were 95 patients with carcinoma of oral cavity, oropharynx, and hypopharynx, among these in 62 cases primary surgery was possible. in seven cases no tumor specific therapy was possible. a complete remission (cr) was obtained in 17% of tumors, partial remission (pr) in 39%. the results after subsequent operation (5 patien ... | 1987 | 3558010 |
| time-dose relationships for local tumor control and complications following irradiation of squamous cell carcinoma of the base of tongue. | between october 1964 and september 1981, 114 previously untreated patients with squamous cell carcinoma of the base of the tongue were treated with curative intent by a radical course of irradiation at the university of florida. with a minimum 2-year follow-up, local control was achieved in 78, 65, 76, and 17% of t1, t2, t3, and t4 lesions, respectively. control results could be correlated with time-dose factors and treatment techniques. no patient required mandibulectomy for osteoradionecrosis ... | 1987 | 3558041 |
| sleep apnea and hypothyroidism presenting as depression in two patients. | two patients are described who presented with depression and were later found to have both obstructive sleep apnea and hypothyroidism. both patients had normal thyroxine (t4) levels but elevated thyroid-stimulating hormone (tsh) levels. thyroid replacement led to resolution of both apnea and depression. the possibility of hypothyroidism as a cause of sleep apnea and depression is discussed. | 1987 | 3558330 |
| leukocytapheresis in inclusion body myositis. | a patient with inclusion body myositis was treated with a course of 22 leukocytaphereses combined with prednisone and azathioprine therapy. he improved clinically during an induction phase of frequent cytapheresis, which reduced the circulating levels of t lymphocytes and monocytes and decreased the ratio of the t4+ to t8+ lymphocyte subsets. during subsequent maintenance cytapheresis there was partial recovery of the t4+ population without recovery of t8+ lymphocytes, and the patient lost most ... | 1987 | 3558342 |
| thyroxine and 3,5,3'-triiodothyronine content of thyroglobulin in thyroid needle aspirates in hyperthyroidism and hypothyroidism. | thyroglobulin (tg) was obtained by fine needle aspiration from patients with untreated hyperthyroidism due to graves' disease and untreated hypothyroidism to determine whether alterations in its t4 and t3 content could account for the disproportionately high serum t3 compared to serum t4 found in both diseases. for comparison aspiration was performed from normal thyroid tissue in euthyroid patients operated for solitary thyroid lesions. the average amounts of tg aspirated were: normal 177 +/- 52 ... | 1987 | 3558731 |
| massive thyroxine intoxication: evaluation of plasma extraction. | six patients were admitted after erroneous massive intake of levothyroxine (70-1200 mg over an interval of 2-12 days). all patients developed classical symptoms of thyrotoxicosis within 3 days of the first dose; five patients presented grade ii-iii coma and one became stuporous (days 7-10). two patients developed left ventricular failure and three had arrhythmias (days 8-11). total thyroid hormone levels in serum on admission ranged 935-7728 nmol/l for t4 (tt4) and 23-399 nmol/l for t3 (tt3). al ... | 1987 | 3558934 |
| inhibitory effect of various radiographic contrast agents on secretion of thyroxine by the dog thyroid and on peripheral and thyroidal deiodination of thyroxine to tri-iodothyronine. | in previous studies we have found that the cholecystographic contrast agent ipodate induced a rapid, sustained and reversible inhibition of thyroxine (t4) secretion from perfused dog thyroid lobes. this type of inhibition of thyroid secretion has not been observed previously. to evaluate whether this effect is unique for ipodate, ten other iodine-containing radiographic contrast agents were tested. the four agents used for cholecystography (iocetamate, iodipamide, ioglycamate and iotroxate) all ... | 1987 | 3559449 |
| iodothyronine 5'-deiodination in rats fed low protein diets: lack of correlation with energy balance. | rats fed low protein diets often exhibit an elevation in adaptive thermogenesis that may result in part from activation of thyroid hormone action at the level of peripheral deiodination of thyroxine (t4) to 3,5,3'-triiodothyronine (t3). this possibility was examined by comparing the kinetic parameters of iodothyronine 5'-deiodination in hepatic and renal microsomes and the efficiency of energy retention in weanling rats fed diets containing 5% (lp-5), 8% (lp-8) or 22% (np) casein. energy balance ... | 1987 | 3559751 |
| combination chemotherapy with cisplatin and methotrexate in advanced transitional cell cancer of the bladder. | we studied 53 patients with bidimensionally measurable metastases of transitional cell cancer of the bladder who were treated with a planned regimen of 70 mg. per m. cisplatin intravenously on day 1, and 40 mg. per m. methotrexate intravenously on days 8 and 15 every 3 weeks. the toxicity of this regimen, with agranulocytosis and mucositis as the most important side effects, was so severe that only 17 per cent of the patients actually received the protocol regimen without modification. six patie ... | 1987 | 3560318 |
| [dynamics of hormones, sugar and electrolytes during hypodynamia according to blood biochemical indices]. | time-course variations in hormones, carbohydrates and electrolytes (specifically, cortisol, aldosterone, testosterone, t3, t4, sugar, potassium, sodium and chlorides) in blood of essentially healthy men, aged 19-59 years, kept for 30 days in a closed life-support system were measured. the hormones, sugar and electrolytes varied in a different manner. the subjects, aged 48-59 years, who performed regular exercises showed a higher stability of potassium, sodium and chlorides and a normalization of ... | 1987 | 3560841 |
| the effect of glutaurine on thyroid hormones in the rat. | glutaurine (gamma-l-glutamyl taurine), a proposed hormone isolated from parathyroid gland oxyphil cells, was examined for its effect on circulating thyroid hormones in the rat. in acute experiments performed over a 24 hr. period, glutaurine depressed plasma triiodothyronine (t3) levels in a dose-dependent manner; however, thyroxine (t4) levels were not affected significantly. in chronic experiments performed over a 2 wk. period, glutaurine significantly increased t3 levels, but, as with acute st ... | 1987 | 3561723 |
| peripheral blood lymphocyte subsets in nasopharyngeal carcinoma. | peripheral blood lymphocyte subsets were studied in 29 untreated chinese nasopharyngeal carcinoma (npc) patients and 20 normal controls of similar age range and sex ratio with indirect immunofluorescence using monoclonal antibodies. the percentage t lymphocyte (t11) count, percentage and absolute t helper (t4) lymphocyte counts and the t helper/t suppressor-cytotoxic cell ratio (t4/t8) were significantly lower, while the percentage and absolute t8 counts were significantly higher in npc patients ... | 1987 | 3561927 |
| immobilization of dna via oligonucleotides containing an aldehyde or carboxylic acid group at the 5' terminus. | a general method for the immobilization of dna through its 5'-end has been developed. a synthetic oligonucleotide, modified at its 5'-end with an aldehyde or carboxylic acid, was attached to latex microspheres containing hydrazide residues. using t4 polynucleotide ligase and an oligonucleotide splint, a single stranded 98mer was efficiently joined to the immobilized synthetic fragment. after impregnation of the latex microspheres with the fluorescent dye, nile red and attachment of an aldehyde 1 ... | 1987 | 3562241 |
| [thyroid function of burned patients: effect of iodine therapy]. | thyroid function was studied in 3 groups of adults (group i = 13 burned patients treated with non iodinated antiseptic, group ii = 15 burned patients treated with polyvidone iodine, group iii = 50 control subjects) in order to examine: the thyroid hormone status in burned patients, the possible incidence of plasma iodine overload on these endocrine parameters. burned skin area and thyroid function were measured before treatment, then weekly for 3 weeks. before treatment a decrease in plasma t4 a ... | 1987 | 3563164 |
| effects of perfluorodecanoic acid on thyroid status in rats. | treatment of rats with toxic doses of perfluorodecanoic acid (pfda) results in reduction in feed intake, body weight, serum thyroxine (t4) and triiodothyronine (t3) concentrations, resting heart rates, and body temperatures. some of these effects resemble changes characteristic of hypothyroidism. therefore the effects of pfda on functional thyroid status were examined to relate changes in thyroid status with signs of pfda toxicity. in the present study, the dose-related effects of pfda on plasma ... | 1987 | 3564018 |
| relationship between serum thyroxine concentration and dialyzable triiodothyronine fraction in patients with hyper- and hypothyroidism. | the interrelationship between the dialyzable triiodothyronine (t3) fraction (dft3), t3, and thyroxine (t4) was examined in various groups of patients with hyper- and hypothyroidism. partial correlational analysis showed that dft3 correlated significantly with t4 (r = 0.383, n = 114, p less than 0.001), but not with t3 (r = 0.132). dft3 exceeded the normal range when t4 was supranormal. the relation between t3 and free t3 (ft3) was quadratic (r2 = 0.944, n = 112, p less than 0.001). when the pati ... | 1987 | 3564843 |
| importance of postmortem changes in measurements of thyroid function in studies of sudden infant death syndrome. | various measurements of thyroid function were made from serum sampled at necropsy by cardiac puncture in adults and compared with the equivalent values before death. there were significant increases in serum total t3 (0.66 before death, 1.14 nmol/l after death), free t3 (0.82 to 1.52 pmol/l), and reverse t3 (1.12 to 1.75 nmol/l); and significant decreases in total t4 (73.7 to 56.6 nmol/l), free thyroxine index (fti) (83.2 to 56.6), and free t4 (14.2 to 11.9 pmol/l). the increase in serum t3, pre ... | 1987 | 3611393 |
| lack of relation between the ventricular refractory period prolongation by amiodarone and the thyroid state in rats. | we investigated the possibility that the prolongation of the ventricular effective refractory period (verp) by amiodarone might be mediated, at least in part, by inhibition of thyroid influence on the heart. verp values were measured in vitro in isolated septal preparations obtained from control, thyroidectomized and thyroxine (tetraiodothyronine; t4)- or triiodothyronine (t3)-treated rats. differences in thyroid influence on the heart between these groups were assessed by changes in the myosin ... | 1987 | 3612535 |
| benign thoracic pain. | seventy-three patients with mid-dorsal and/or unilateral chest pain seen consecutively in the rheumatology clinic by a single clinician over a three-year period were studied, after exclusion of visceral disease. the majority were young women. the pain was dull and continuous, was aggravated by coughing and sneezing and relieved by rest. there was frequently tenderness over the thoracic spine (t4-5) and an adjacent rib, and pain at extremes of thoracic spinal movement in one or two directions was ... | 1987 | 3612661 |
| mitogen induced lymphoproliferative responses and lymphocyte sub-populations in patients with sickle cell disease. | mitogen induced lymphoproliferative responses and lymphocyte sub-populations were studied in a group of sickle cell disease (scd) patients with homozygous ss hemoglobinopathy. even though the response to a sub-optimal dose of con a (0.5 microgram/ml of culture) was significantly decreased in patients with scd, the proliferative responses to optimal doses of con a, to pha and to pwm were preserved in the patients. addition of indomethacin to the cultures increased to a more significant degree the ... | 1987 | 3612755 |
| sense and antisense transcription of bacteriophage t4 gene 32. processing and stability of the mrnas. | analysis of bacteriophage t4 gene 32 transcription has revealed a multiplicity of mrnas. in plasmids, gene 32 is expressed primarily from a strong promoter that is shut off after phage infection. in a wild-type infection, gene 32 is initially transcribed from prereplicative polycistronic and monocistronic promoters; subsequently, a monocistronic late mrna predominates. this transcript, as well as a post-transcriptionally processed product of the earlier mrna, can be stable. the eventual degradat ... | 1987 | 3612804 |
| genetic control of capsid length in bacteriophage t4: clustering of ptg mutations in gene 23. | fifty-two new bacteriophage t4 ptg mutations have been isolated by selecting for the giant-capsid phenotype they display. genetic mapping placed all of them at eight sites, all located in gene 23. these sites were clustered in three locations, one near amber b17 (gene 23 nucleotide [nt] 268), another centrally placed between ame506 (nt 706) and ame1270 (nt 925), and the third between amc208 (nt 1297) and ame1236 (nt 1489). the lack of a selective system for identifying recombinant genotypes when ... | 1987 | 3612952 |
| genetic control of capsid length in bacteriophage t4: dna sequence analysis of petite and petite/giant mutants. | the t4 gene 23 product (gp23) encodes the major structural protein of the mature capsid. mutations in this gene have been described which disrupt the normal length-determining mechanism (a.h. doermann, f.a. eiserling, and l. boehner, j. virol. 12:374-385, 1973). mutants which produce high levels of petite and giant phage (ptg) are restricted to three tight clusters in gene 23 (a.h. doermann, a. pao, and p. jackson, j. virol. 61:2823-2827, 1987). twenty-six of these ptg mutations were cloned, and ... | 1987 | 3612953 |
| genetic control of capsid length in bacteriophage t4: phenotypes displayed by ptg mutants. | the phenotypic characteristics of 26 ptg mutations in t4 gene 23 are described. all were located in three tight clusters in that gene and, by definition of ptg mutations, all produced giant phage. intermediate petite phage, which invariably made up a substantial fraction of the progeny of these mutants, appeared to be a unique product of gene 23 mutations. isometric petite phage were produced in significant numbers by strains with mutations at only 4 of the 10 sites identified with the ptg pheno ... | 1987 | 3612954 |
| treatment of invasive bladder cancer by cisplatin and radiation in patients unsuited for surgery. | seventy patients with muscle-invading bladder carcinoma (clinical stages t2 to t4) who were not candidates for cystectomy were treated with combined cisplatin and full-dose external-beam radiation on a multi-institutional prospective protocol from 1980 through 1985. thirty-six patients are alive, all but three without evidence of cancer. the complete response rate is 77% in the 62 patients completing planned irradiation and 70% for all patients. among the complete responders, 73% are currently m ... | 1987 | 3613023 |
| growth rate of male germfree wistar rats fed ad libitum or restricted natural ingredient diet. | germfree life and feed restriction initiated at an early age are known to extend life span. we have examined growth rate and life expectancy in germfree (gf) and conventional (cv) male lobund wistar rats, fullfed (f) or restricted (r) to 12 grams/day of natural ingredient diet l-485. gf-f and cv-f rats show comparable growth rates during the first 6 months of life. thereafter, the gf-f rat falls behind, with its body weight stabilizing at 85% of the cv rat's weight at 2 years of age (510 g vs 43 ... | 1987 | 3613511 |
| carcinoma of the larynx. | six hundred sixty-eight patients with tumours of the larynx were treated by radiotherapy. the patients had stage t1 n0 m0 to t4 n3 m0 disease. patients with t1 n0 m0 disease (273) had an excellent long-term survival (90%) as did those with t2 n0 m0 disease (142), whose 5-year survival was 70%. patients with more advanced disease but no nodal spread did not respond as readily to radiotherapy; the 5-year survival was 40%. all patients were treated using a parallel pair set-up 6 x 6 cm lateral neck ... | 1987 | 3613590 |
| [thyroid function diagnosis based on an analysis of sensitive tsh and free t4 is a simple rapid routine]. | 1987 | 3613768 | |
| characterization of type-ii thyroxine 5'-deiodinase activity in rat harderian gland. | thyroxine 5'-deiodinase activity was studied in male rat harderian gland homogenates. the reaction rate was proportional to the tissue content in the homogenate and dependent on ph, with an optimum ph of 7.0, and temperature, between 4-37 degrees c. 5'-deiodinase activity was increased by dithiothreitol (dtt) in a dose-dependent manner, and inhibited moderately by propylthiouracil (ptu) and strongly by iopanoic acid (ia). thyroidectomy enhanced the enzymatic activity (30-fold above the control v ... | 1987 | 3613871 |
| [spinal epidural meningioma--a case report with special reference to neuroradiological findings]. | spinal meningiomas are common as intradural-extramedullary neoplasm, but solitaly epidural spinal meningiomas are extremely rare. they may often be misdiagnosed as malignant neoplasms which are much more common in this location. furthermore, at the time of operation, it is often difficult to distinguish the epidural meningioma from malignant tumors, even by the microscopic examination of the fresh frozen section. we present a case of spinal epidural meningioma, and emphasize the importance of pr ... | 1987 | 3614538 |
| thyroxine-induced molting and gonadal function of laying hens. | twenty laying hens, 238 days of age, were divided into four groups which received daily intramuscular injections of l-thyroxine (t4) (0, 20, 100, or 500 micrograms/kg body weight per day) for 4 weeks. there was no change in body weight or egg production rate of the control (0 microgram t4) or of 20 and 100-micrograms t4 groups over time. body weight and egg production of the 500 micrograms t4 group decreased markedly and molting started 10 days after t4 injection. circulating iodothyronine (t4), ... | 1987 | 3615336 |
| time course of changes in plasma concentrations of the growth related hormones during protein restriction in the domestic fowl (gallus domesticus). | experiments were conducted to evaluate the possible role of circulating growth hormones triiodothyronine (t3), thyroxine (t4), and insulin-like growth factor i (somatomedin-c; igf-i) in the elevation of plasma growth hormone (gh) which occurs in protein-restricted chickens. plasma hormone changes were determined over a 2-week period of protein depletion by feeding a 5% protein diet as well as a similar period of protein repletion with a 20% protein diet. the rise in plasma gh was observed in two ... | 1987 | 3615409 |
| examination stress affects plasma levels of tsh and thyroid hormones differently in females and males. | plasma levels of tsh and thyroid hormones in 22 male and 27 female medical students were determined by radioimmunoassay before and after an academic examination. the plasma values of tsh were slightly higher in both sexes on the examination day than on the control days. the values were lower after the examination than before it in females but not in males. plasma levels of t3 were higher in males than in females on the examination day. in contrast, the plasma rt3 values were higher for females o ... | 1987 | 3615767 |
| effects of food restriction on cortisol, tsh and iodothyronine concentrations in the plasma of the newborn lamb. | the influence of food restriction, applied from birth to 36 h post partum, on neonatal thyroid function was studied in newborn limousin x romanov lambs. the control animals (n = 18) had free access to the mother and suckled ad libitum. restricted lambs (n = 16) were removed from the mother and received limited amounts of colostrum in proportion to birth weight; 8 lambs were supplemented with lactose (30 g/l of colostrum). plasma glucose and free fatty acid levels were significantly lower in rest ... | 1987 | 3616134 |
| effects of l-thyroxine in rats with chronic heart failure after myocardial infarction. | the effects of thyroid hormone on left ventricular (lv) function and myosin isoenzyme distribution were evaluated in rats 3 wk after myocardial infarction. when compared with normal rats, animals selected for study had moderately severe lv dysfunction as judged by decreased aortic and lv systolic pressures and a 34% decrease in lv maximum rate of pressure development (dp/dt). average lv end-diastolic pressure was increased to 26 +/- 1 mmhg from 5 +/- 1 mmhg. the infarcted rats were divided into ... | 1987 | 3618809 |
| adrenal, thyroid, and testicular hormone rhythms in male golden hamsters on long and short days. | plasma concentrations of adrenal, thyroid, and testicular hormones were measured at 4-h intervals around the clock in male hamsters on long (14:10-h light-dark cycle) and short (10:14-h light-dark cycle) days. plasma corticosterone, cortisol, thyroxine (t4), triiodothyronine (t3), and testosterone rhythms were present on long days. the only one of these hormones to have a significant rhythm on short days was cortisol, but even its amplitude was suppressed compared with the cortisol rhythm on lon ... | 1987 | 3618832 |
| progressive histopathologic abnormalities in the persistent generalized lymphadenopathy syndrome. | using a quantitative classification, we evaluated serial lymph node biopsies in 20 homosexual men with persistent generalized lymphadenopathy (pgl), and correlated the results with peripheral blood lymphocyte counts and clinical findings. in a median follow-up interval of 19 months, ten patients (50%) had progression from one histologic subtype of this disorder to another. lymph nodes from the other 10 patients also demonstrated decreased numbers of organized follicles in the most recent specime ... | 1987 | 3618883 |
| enhanced repair of pyrimidine dimers in coding and non-coding genomic sequences in cho cells expressing a prokaryotic dna repair gene. | we have previously demonstrated that the active dihydrofolate reductase (dhfr) gene is efficiently repaired in chinese hamster ovary (cho) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. preferential dna repair of essential genes may explain why the u.v. resistance of normal cho cells is as high as that of fully repair-proficient normal human cells. in this report, we have studied the removal of pyrimidine dimers in a cho cell line expressing t ... | 1987 | 3621470 |
| the role of lymphocyte subset analysis in defining the clinical evolution of multiple sclerosis. | thirty patients with definite multiple sclerosis (ms) were examined monthly for one year. each time, neurological examination, clinical history and monoclonal-antibody-defined t cell subsets were evaluated. particularly, the helper/suppressor ratio (t4/t8) and the t4/t8 test-to-test variability (delta t4/t8) were considered in relation to the occurrence of clinical exacerbations. statistically significant correlations were found between clinical course and laboratory parameters, suggesting a pos ... | 1987 | 3622575 |
| effect of amiodarone on myosin isoenzymic distribution in rat ventricular myocardium. | rats were given amiodarone (50 mg x kg-1 x day-1, orally) for 4 weeks and the distribution of ventricular isomyosins, a sensitive index of the effects of thyroid hormones on cardiac tissue, was analyzed. amiodarone treatment induced a marked increase in both t4 and rt3 and tended to decrease t3 serum levels. at the pharmacologically active dosage we used, the drug induced a moderate redistribution of ventricular isomyosins in favour of v, at the expense of v1. our results do not support the hypo ... | 1987 | 3622612 |
| effects of metamorphosis and captivity on the in vitro sensitivity of thyroid glands from the tiger salamander, ambystoma tigrinum, to bovine thyrotropin. | the sensitivity of thyroid glands from the tiger salamander, ambystoma tigrinum, to bovine thyrotropin (btsh) was tested in vitro. thyroids were taken from subjects representing metamorphic stages i (premetamorphic larvae), ii (onset of climax), and vii (completion of gill resorption), as well as from captivity control larvae. exogenous tsh reduced the cumulative uptake of 125i in vitro by thyroids from stage i larvae after 24 and 48 hr. the capacity of thyroids to release thyroxine (t4) in vitr ... | 1987 | 3623072 |
| damage in dna of an infecting phage t4 shifts reproduction from asexual to sexual allowing rescue of its genes. | 1987 | 3623097 | |
| growth hormone stimulates the peripheral conversion of thyroxine into triiodothyronine by increasing the liver 5'-monodeiodinase activity in the fasted and normal fed chicken. | normal fed and 2 days fasted warren chickens were injected intravenously with 100 micrograms of ovine growth hormone (gh) and ovine prolactin and plasma concentrations of thyroid hormones were assayed prior and up to 2 h after injection. fasting alone decreases t3, but increases t4. an injection of gh resulted in increases of plasma t3 concentrations in two fasting experiments by 40% (after 3/4 h) and 104% (after 1 h). in normal fed animals no increase is observed in the first experiment, wherea ... | 1987 | 3623420 |
| low serum reverse t3 levels in patients with primary hyperparathyroidism. | although patients with primary hyperparathyroidism (1 degree hpt) were euthyroid, we measured serum thyroid hormone levels in 16 patients with 1 degree hpt together with 17 patients with hypercalcemia due to malignant diseases (hcm). in patients with 1 degree hpt, serum levels of t3, t4 and t3u were within normal range, but serum rt3 (reverse t3) levels (205 +/- 37 pg/ml, mean +/- sd) were significantly decreased as compared with those in normal controls (276 +/- 44 pg/ml, p less than 0.01). a s ... | 1987 | 3623422 |
| enhanced mucosal reactions in aids patients receiving oropharyngeal irradiation. | the oropharynx and hypopharynx are common sites of involvement in aids patients with mucocutaneous kaposi's sarcoma. the radiotherapist is often asked to intervene with these patients due to problems with pain, difficulty in swallowing, or impending airway obstruction. we have noted an unexpected decrease in normal tissue tolerance of the oropharyngeal mucosa to irradiation in aids patients treated in our department. data on 12 patients with aids and kaposi's sarcoma receiving oropharyngeal irra ... | 1987 | 3624048 |
| myocardial infarction in graves' disease without coronary artery disease. | a 45-year-old female without coronary risk factors showed a 20 kg decrease in body weight, hyperhydrosis, palpitations and dyspnea on exertion for 2 months, and nocturnal dyspnea for 1 month before admission. she did not notice chest pain indicative myocardial infarction or fever suggestive myocarditis. graves' disease was confirmed by exophthalmos and elevated titers of t3 and t4 thyroid hormones. cardiac catheterization studies demonstrated no significant coronary artery disease but showed aki ... | 1987 | 3626027 |
| [thyroid hormone content of the blood plasma and tolerance for physical loading in ischemic heart disease patients]. | blood thyroid hormones were measured before and after the rationed exercise test in 79 patients with angiographically verified diagnosis of coronary heart disease. a relationship was demonstrated between postexercise blood t3 variation and functional coronary circulation reserve. hormonal baselines, and exercise-induced blood t4 changes were basically similar in patients with coronary disease of different severity. the results are suggestive of pathogenetic importance of thyroid function in thes ... | 1987 | 3626292 |
| recombinational repair of hydrogen peroxide-induced damages in dna of phage t4. | recently, hydrogen peroxide and its free-radical product, the hydroxyl radical (oh.) have been identified as major sources of dna damage in living organisms. they occur as ubiquitous metabolic by-products and, in humans, cause several thousand damages in a cell's dna per day. they are thought to be a major source of dna damage leading to aging and cancer in multicellular organisms. this raises two questions. first, what pathways are used in repair of dna damages caused by h2o2 and oh.? second, a ... | 1987 | 3627145 |
| thyroid function tests in patients undergoing maintenance dialysis: characterization of the 'low-t4 syndrome' in subjects on regular hemodialysis and continuous ambulatory peritoneal dialysis. | thyroid function tests were evaluated in 38 patients on regular hemodialysis (hd), in 36 on continuous ambulatory peritoneal dialysis (capd) and in 39 healthy controls. a significant reduction in total thyroxine (tt4), total triiodothyronine (tt3), reverse (rt3), and free t4 (ft4) mean levels and normal tsh, free t3, tbg and albumin concentrations was found in both hd and capd patients. a 'low-t4 syndrome' (serum t4 less than 5 micrograms/dl) was found in 9 capd (25%) and 20 hd (53%) patients, b ... | 1987 | 3627315 |
| alpha-dna. iv: alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. synthesis, physicochemical properties and poly (ra) binding. | a new set of molecules made of an intercalating agent (oxazolopyridocarbazole, opc) covalently linked through a polymethylene chain of various length to the 3' end of alpha-anomeric or beta-anomeric tetradeoxynucleotides (alpha- or beta-t4) have been synthesized. the beta-thymidylate modified compound (beta-t4c5opc) is able to interact with the complementary sequence, beta-poly (ra); this interaction is strongly stabilized compared to the parent compound, beta-oligo(dt)4 and is specific for poly ... | 1987 | 3628001 |
| nucleotide sequence of gene t (lysis gene) of the e. coli phage t4. | 1987 | 3628006 | |
| circadian and circannual variations of thyroid function in children 11 +/- 1.5 years of age with and without endemic goiter. | a group of 194 children 11 +/- 1.5 years of age from tirgoviste, romania, an endemic goiter area, were studied over a 24-hr span (six blood samples at 4-hr intervals) during all four seasons. one hundred thirty-four of the children had some clinical evidence of endemic goiter, and 60 had none. total and free t3 and t4, reverse t3, thyroglobulin, thyroxin-binding globulin (tbg; three seasons only), and tsh were studied. the circadian rhythms were analyzed by cosinor and the circannual variations ... | 1987 | 3628335 |
| circatrigintan rectal temperature and endocrine rhythms of clinically healthy, menstrually cycling women. | rectal temperatures were measured automatically every 10 min for part or most of two menstrual cycles in ten clinically healthy young women, 20-30 years of age, with a wearable instrument, the polychronor. occasional malfunction of the instrumentation resulted in corresponding gaps in the series. data were examined by chronograms, plexograms, and chronobiologic serial sections computed with the fit of a 24-hr period, population-mean cosinor, and linear-nonlinear least-squares analyses. single co ... | 1987 | 3628361 |
| carcinoma of the soft palate treated with irradiation: analysis of results and complications. | this is an analysis of 75 patients with squamous cell carcinoma of the soft palate and/or uvula treated with radical radiation therapy alone (64) or in conjunction with planned neck dissection (11) between october 1964 and september 1983. all patients have a minimum follow-up of 2 years and 60 (80%) have a minimum follow-up of 5 years. patients were excluded from analysis of disease control at the primary site and/or neck if they died within 2 years of treatment with the site(s) continuously dis ... | 1987 | 3628855 |
| effects of hyper- or hypothyroid status on growth, adiposity and levels of growth hormone, somatomedin c and thyroid metabolism in broiler chickens. | relatively few methods involving dietary manipulation of thyroid status have been used to study the effect of that status on growth and body composition as well as on changes in hormone levels and metabolism. the present work examines the influence of either a hyperthyroid status (induced by feeding triiodothyronine: t3 or thyroxine: t4) or a hypothyroid status (induced by feeding methimazole: mmi) on growth, feed consumption and body composition as well as on changes in thyroid hormone levels a ... | 1987 | 3628953 |
| [current aspects of surgery of benign struma]. | preoperative procedures, surgical techniques, and postoperative management are discussed in this paper, against the background of latest developments and with reference to 443 struma patients who received surgical treatment in 1984 and 1985. the technique of surgical removal has been modified by the author, as compared to what it used to be back to 1964. ligature of the inferior thyroid artery has been abandoned. the postoperative rate of unilateral nerve palsy recurrence has been reduced from 4 ... | 1987 | 3630454 |
| [reactions of the thyroid gland in the acute period of craniocerebral injuries]. | the authors analysed individual graphic images of the hormonal profile according to the content of thyroid hormones (t4, t3) in blood of 32 patients with severe and moderate brain contusion. four types of thyroid gland responses can be distinguished according to the severity and clinical features of the contusion, which can be used as a differential-diagnostic and prognostic criterion in certain types of craniocerebral trauma. | 1987 | 3630514 |
| sympathetic activity and haemodynamic variables during spinal analgesia in man. | at present there is a lack of information concerning haemodynamic changes related to the degree of sympathetic blockade during spinal analgesia. in this investigation, involving 36 patients, changes in haemodynamic parameters were studied in 30 patients receiving spinal analgesia and in six patients having "sham spinal" analgesia. three local anaesthetic solutions were used: bupivacaine without and with glucose and tetracaine with glucose. skin conductance responses were used to evaluate changes ... | 1987 | 3630592 |
| spinal anaesthesia with hyperbaric tetracaine: effect of age and body mass. | to discover the influence of age and body mass on spinal analgesia with hyperbaric tetracaine, 60 patients (17-82 years) were administered a subarachnoid injection of 15 mg tetracaine in 3 ml of 5% glucose. the patients were in the lateral position during the injection and in the supine position thereafter. the maximal spread of analgesia (mean t4, range t1-t11) did not correlate with age or body mass. any variable studied was not significantly different for the different age groups. in 29 patie ... | 1987 | 3630593 |
| remission in children with hyperthyroidism treated with propylthiouracil. long-term results. | we treated 69 hyperthyroid children with propylthiouracil, of whom 53 remained under surveillance. of these children, 34 (64%) had an initial remission, but relapses were frequent (47%). at this writing, 24 patients (45%) were in remission, with a mean duration of remission of 55 months (range, ten to 132 months). we found that the triiodothyronine level took significantly longer than the thyroxine (t4) level to return to normal. thus, based on the t4 level alone, treatment may have been stopped ... | 1987 | 3630994 |
| diagnosis of hypothyroidism in patients with end-stage renal disease. | hypothyroidism may occur more commonly in patients with end-stage renal disease (esrd) than in the general population. the signs and symptoms of both hypothyroidism and uremia may be similar. to evaluate the usefulness of clinical and routine laboratory findings in the diagnosis of hypothyroidism in patients with esrd, we compared 6 patients with documented primary hypothyroidism who had serum thyrotrophin (tsh) levels above 20 microu/ml with 12 euthyroid patients. the euthyroid patients were di ... | 1987 | 3631149 |
| optimal response of key enzymes and uncoupling protein to cold in bat depends on local t3 generation. | we have examined the activity of three lipogenic enzymes [malic enzyme (me), glucose-6-phosphate dehydrogenase (g-6-pd), and acetyl coenzyme a (coa) carboxylase], the activity of the mitochondrial fad-dependent alpha-glycerolphosphate dehydrogenase (alpha-gpd), and the mitochondrial concentration of uncoupling protein (ucp) in brown adipose tissue (bat) of euthyroid and hypothyroid rats, both at room temperature and in response to acute cold stress. these enzymes and ucp are important for the th ... | 1987 | 3631256 |
| peripheral metabolism of thyroid hormones and iodide in healthy and hyperthyroid cats. | the metabolic clearance rate, volume of distribution, and fractional clearance rate of thyroxine (t4), triiodothyronine (t3), and iodide were calculated for 6 healthy and 7 hyperthyroid cats, using single-compartmental and noncompartmental methods of analysis. the mean t4 volume of distribution of the hyperthyroid cats was 32.0% less than that of the healthy cats; it was the only variable that was significantly different (p less than 0.05) between these 2 groups of cats. the mean fractional clea ... | 1987 | 3631720 |
| [a case report of inflammatory breast cancer effectively treated with cis-platinum]. | a 50-year-old woman with bilateral inflammatory breast cancer (t4, n1b, m1, stage iv) underwent right extended radical mastectomy and left modified radical mastectomy following pre-operative administration of carcinostatics (adm, 5-fu) and irradiation. however, tumor recurrence was observed at the skin and right pleural cavity after the operation. adriamycin-containing combination chemotherapy and radiation therapy were performed, but no significant response was obtained. cddp was then administe ... | 1987 | 3631975 |
| transport of p-aminohippurate in renal cortical slices of rats of different ages following treatment with thyroid hormones. | following treatment with thyroid hormones pah accumulation is increased in renal cortical slices of 5-, 10-, 20-, 30-, 50- and 105-day-old rats. both thyroid hormones are more effective in young than in adult rats. a single dose of t3 or t4 (20 micrograms/100 g b.m.) administered 24 h before measurement is effective whereas acute effects of t3 or t4 on pah transport could not be demonstrated. treatment with thyroid hormones (20 micrograms/100 g b.m., 3 days, once a day) is without any influence ... | 1987 | 3632649 |
| productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. | thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. a susceptible colon carcinoma cell line (ht29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(a)+ cd4 rna, whereas uninfectible colon carcinoma and rhabdomyos ... | 1987 | 3640832 |
| tissue kallikrein in rat brain and pituitary: regional distribution and estrogen induction in the anterior pituitary. | we have detected tissue kallikrein and kallikrein mrna in various brain regions with a kallikrein direct ria and with nucleic acid hybridization using a kallikrein cdna probe. in the direct ria, rat urinary kallikrein-like activity was found in the pituitary and pineal glands, hypothalamus, cerebral cortex, cerebellum, and brain stem. pituitary and pineal gland kallikrein concentrations were significantly higher than those in other regions. only in pituitary was there a significant difference in ... | 1987 | 3643103 |
| thyroid hormone profile in dairy cattle acclimated to cold or hot environmental temperatures. | milk yields and the circulating profile of t4, t3 and rt3 were assessed during three different seasons of the year, in first trimester lactating (l) and in dry (d) multiparous holstein cows acclimated to distinct weather conditions. within the thermoneutral zone (18-28 degrees c; 40-60% rh) and regardless of their geographical location, the thyroid hormone profile in all l-cows (n = 50) resembled the so-called euthyroid sick syndrome (t4, 43.7 +/- 7.7 nmol/l; t3, 1.31 +/- 0.10 nmol/l and rt3, 0. ... | 1987 | 3644585 |
| human immunodeficiency virus in brain biopsies of patients with aids and progressive encephalopathy. | human immunodeficiency virus (hiv) has been identified in patients with aids in their circulating and tissue lymphocytes and in their monocyte-macrophages, an arm of the cell-mediated immune system. we report our findings of hiv in brain biopsies. virus was detected in oligodendroglial and astroglial cells. virus was also present in the brain capillaries, both in lumens and at the endothelial gaps. virus was also found in extracellular spaces. budding forms of the developing virus and bar-shaped ... | 1987 | 3644852 |