Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| serum concentrations of total and free thyroid hormones in moderately obese women during a six-week slimming cure. | successive determinations of serum total (t4) and free (ft4) thyroxine, total (t3) and free (ft3) 3,5,3'-triiodothyronine and total 3,3',5'-triiodothyronine (rt3) concentrations were performed by radioimmunoassay in 17 moderately obese women during a 6-week slimming cure. the 2.09 mj/d (500 kcal/d) diet (50 per cent protein, 25 per cent carbohydrate and 25 per cent lipid) was given as three daily meals of general foods. during the cure, the body mass index (bmi) decreased by about 10 per cent, w ... | 1988 | 3396520 |
| [an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3'-triiodothyronine (iec) in plasma of patients with various nonthyroidal illnesses]. | to evaluate the role of a circulating inhibitor of extrathyroidal conversion of t4 to t3 (iec) in the causation of low t3 states in patients with various nonthyroidal illnesses (nti), we measured the in vitro t3 production in the presence of ether extract of plasma. blood samples were obtained from 22 normal subjects and 140 patients with various nti; liver cirrhosis (lc) 37, diabetes mellitus (dm) 48, respiratory failure (rf) 15, chronic renal failure (crf) 10 and others 30. the assay procedure ... | 1988 | 3396731 |
| [thyroid hormone metabolism in nonthyroidal illness. i. changes in thyroid hormone metabolism in dogs with experimental myocardial infarction and effect of thyroid hormone administration on their hemodynamics]. | to asses the changes in thyroid hormone metabolism after the onset of acute myocardial infarction (ami), serum t4 and t3 levels were serially measured for 24 hours after the coronary artery ligation in dogs. the effect of thyroid hormone administration on hemodynamics in these dogs were also studied to clarify the possible usefulness of thyroid hormone therapy in nonthyroidal illness (nti). dogs were anesthetized with ketamine using "micro-mini" drip administration. coronary artery ligation was ... | 1988 | 3396732 |
| lymphocyte proliferative responses in haemophiliac patients: relations to clinical and immunological findings. | blood lymphocyte proliferative responses to mitogens were studied in 65 patients with haemophilia (haemophilia a: 54 patients, haemophilia b: 11 patients) in parallel with 39 male control subjects. as a group, patients with haemophilia did not demonstrate abnormal proliferative responses to phytohaemagglutinin (pha), concanavalin a (cona) and pokeweed mitogen (pwm) when compared with healthy controls. when the patients were analysed according to their seropositivity for antibody to human immunod ... | 1988 | 3396972 |
| effect of ethanol and linoleic acid on changes in biliary excretion of iodothyronines possibly related to thyroxine deiodination in rat liver. | groups of male rats weighing about 350 g were inserted polyethylene tubings into bile duct and femoral vein under pentobarbital anesthesia. several iodothyronines (i.e. t4, t3, rt3, 3,5-t2, 3,3'-t2 and 3',5'-t2) were estimated in 2-hr portions of bile with the aid of specific radioimmunoassay. after the infusion of ethanol (0.3 ml/hr/rat for 4 hr) an increase of biliary excretion of rt3 and a decrease of 3,5-t2 was found as compared to controls. when 5 mg linoleic acid was added to 1.2 ml ethano ... | 1988 | 3397033 |
| postnatal thyroxine administration for idiopathic respiratory distress syndrome in preterm infants. | thirty-six preterm infants of less than 34 weeks of gestation with idiopathic respiratory distress syndrome (irds) were studied. eighteen of them were treated with intravenous thyroxine (t4) and compared with 18 control prematures to evaluate the effect of postnatal t4 administration on the course of irds. after treatment, serum t4 levels were similar to those of healthy term infants. no statistically significant effect on mortality rate, duration of mechanical ventilation (p greater than 0.3), ... | 1988 | 3397040 |
| the effects of acute physical exercise on blood serum cholesterol, triglycerides, human growth hormone (h.g.h.) and free thyroxine (t4) in men over fifty years of age. | 1988 | 3398514 | |
| [a case of spontaneous cervical epidural hematoma associated with cervical spondylosis]. | a case of spontaneous cervical epidural hematoma associated with long-term cervical spondylosis is presented. a 69-year-old man was admitted with a 3-day history of sudden onset of severe neck pain radiating to both upper extremities followed by impossibility in standing. neurological examination on admission revealed paralysis below c7, total anesthesia below the t4 level and urinary incontinence. initially, he was diagnosed as cervical cord injury caused by a violent fall. subsequently, skelet ... | 1988 | 3399009 |
| differential activity of thymosin peptides (thymosin fraction 5) on plasma thyrotropin in female rats of different ages. | thymosin fraction 5 (tf-5), a partially purified thymic preparation, has been previously shown to have luteinizing-hormone-releasing-hormone-releasing activity in perfused rat hypothalamus as well as an in vivo stimulatory effect on the pituitary-adrenal axis in prepubertal monkeys. we report here the effect of tf-5 on the plasma levels of several hormones in female rats of different ages. conscious free-moving sprague-dawley rats carrying an indwelling atrial cannula received a single dose of 5 ... | 1988 | 3399026 |
| vasoactive intestinal peptide treatment that increases thyroid blood flow fails to alter plasma t3 or t4 levels in the rat. | vasoactive-intestinal-peptide (vip)-containing nerve fibers impinge upon both follicle cells and blood vessels in the thyroid gland. we have previously shown that vip induces a specific, dose-related increase in thyroid blood flow in the rat. however, our vip treatments had no effect on circulating thyroid hormone levels. since a number of reports have indicated that vip can enhance thyroid hormone secretion, we have expanded our studies to characterize more completely the conditions under which ... | 1988 | 3399036 |
| ring-opened 7-methylguanine residues in dna are a block to in vitro dna synthesis. | single-stranded m13mp18 phage dna was methylated with dimethylsulfate (dms), and further treated with alkali to ring-open n7-methylguanine residues and yield 2-6-diamino-4-hydroxy-5n-methylformamidopyrimidine (fapy) residues. nucleotide incorporation during in vitro dna synthesis on methylated template using e. coli dna polymerase klenow fragment (kf polymerase) was reduced compared to the unmethylated template. additional treatment of the methylated template with naoh to generate fapy residues, ... | 1988 | 3399381 |
| parallel stranded duplex dna. | three linear 21-nt oligonucleotides (c2, c3, c7) have been synthesized with different sequences of a and t residues. one pairwise combination, (c3, c7), hybridizes to form a conventional antiparallel duplex (aps-c3.c7), whereas the pair c2, c3 forms a duplex (ps-c2.c3) in which the two strands are in a parallel orientation and the a.t base-pairs in a reverse watson-crick configuration. the existence of the novel ps helical structure was established from the following criteria: (i) the electropho ... | 1988 | 3399411 |
| [results of radiotherapy of carcinomas of the retromolar trigone observed at the varese regional hospital]. | retromolar trigone carcinomas (rtc) are generally diagnosed at an advanced stage in spite of their accessible location. from december 1979 to january 1987 we examined 23 patients with rtc at the varese regional hospital--three women and 20 men, with an average age of 62.9 years. 21/23 patients were heavy cigarette smokers and consumed more than 1 l of alcohol per day. the patients were classified as 1 t1, 9 t2, 9 t3 and 4 t4 on the basis of tnm classification of malignant tumors. at the beginnin ... | 1988 | 3399712 |
| parallel stranded dna. | a series of four hairpin deoxyoligonucleotides was synthesized with a four-nucleotide central loop (either c or g) flanked by the complementary sequences d(t)10 and d(a)10. two of the molecules contain either a 3'-p-3' or 5'-p-5' linkage in the loop, so that the strands in the stem have the same, that is, parallel (ps) polarity. the pair of reference oligonucleotides have normal phosphodiester linkages throughout and antiparallel (aps) stem regions. all the molecules adopt a duplex helical struc ... | 1988 | 3399890 |
| apparent isolated elevation of serum triiodothyronine level in a patient with a thyroid nodule. | cystic thyroid nodules most commonly occur with a euthyroid state and appear as cold lesions on radioactive iodine scan. i describe a 32-year-old woman who presented during the third trimester of her second pregnancy with a toxic cystic lesion of the thyroid. in studies performed post partum, the serum free thyroxine (t4) index was normal, while the triiodothyronine (t3) level was elevated and thyrotropin level was low and unresponsive to thyrotropin-releasing hormone stimulation. iodine 123 thy ... | 1988 | 3401110 |
| sequence specificity in photoreaction of various psoralen derivatives with dna: role in biological activity. | the sequence specificity in the photoreaction of various psoralen derivatives with dna is investigated by using dna sequencing methodology. the 3'-5' exonuclease activity associated with t4 dna polymerase serves as a probe to map the psoralens' photoaddition (monoadducts plus biadducts) on dna fragments of defined sequence. this approach has already allowed us to demonstrate a strong sequence context effect on the 8-methoxypsoralen photobinding to dna [sage, e., & moustacchi, e. (1987) biochemis ... | 1988 | 3401463 |
| transitional cell carcinoma of the urethra in men after radical cystectomy for bladder cancer. is prophylactic urethrectomy indicated? | a retrospective study of the incidence and clinical course of transitional cell carcinoma of the urethra is reported. of 110 consecutive male patients who underwent cystectomy during a 9-year period, 9 had or developed a urethral tumour. five patients undergoing radical cystectomy had known or suspected urethral involvement which was confirmed at urethrectomy. all 5 had deeply invasive (t3 or t4) transitional cell carcinomas of the bladder and subsequently died of metastatic disease. four patien ... | 1988 | 3401661 |
| nyctohemeral rhythms of gonadal, thyroid and pineal function in the hyperprolactinemic male rat. | in young adult male rats bearing a donor anterior pituitary gland grafted for 3 weeks under a kidney capsule, serum prolactin (prl) concentrations were elevated and exhibited a rhythm with the highest values in the light phase. serum prl in control animals did not exhibit a significant rhythm. eutopic pituitary prl content, manifesting a biphasic (12-hr) rhythm with crests during the day and night in controls, exhibited a similar pattern in grafted rats though an overall reduction in pituitary p ... | 1988 | 3401975 |
| [comparative analysis of dna-ligase genes of phages t6 and t4]. | 1988 | 3402337 | |
| effects of tumor necrosis factor-alpha/cachectin on thyroid hormone metabolism in mice. | to elucidate the mechanism by which low t3 and low t4 syndrome occurs in patients with acute or chronic infection or malignancy, recombinant human tumor necrosis factor-alpha (tnf-alpha)/cachectin (tnf) was administered ip to mice and thyroid hormone metabolism was studied. since administration of tnf caused a decrease in food intake and body weight, all experiments were performed using pair-fed control (pfc) mice. administration of tnf at a dose of 1-100 micrograms/day for 3 days decreased seru ... | 1988 | 3402392 |
| [morphometric studies on the lateral habenular nucleus of wistar rats after bilateral excision of the superior cervical ganglia and cold exposure with special reference to the pineal gland]. | to analyse the role of peripheral sympathetic fibres in the regulation of thyroxine (t4), serum thyrotropin (tsh), pituitary tsh, and nuclear size of the lateral habenular nuclei rats were studied 30 d after bilateral cervical ganglionectomy (gx). in order to examine the influence of gx at normal temperature (24 degrees c) and exposure to cold (10 degrees c), rats were subjected to a 72 h exposure to cold before killing. 4 times a day (light-dark cycle: 14l: 10d, light on 05h00) the rats were sa ... | 1988 | 3402714 |
| measurement of t4, t3 and reverse t3 levels, resin t3 uptake, and free thyroxin index in blood from the intervillous space of the placenta, in maternal peripheral blood, and in the umbilical artery and vein of normal parturients and their conceptuses. | t4, t3, and reverse t3 (rt3) levels and the free thyroxine index were measured in blood collected from the intervillous space (ivs) after placental expulsion and compared to the values in maternal peripheral blood and in umbilical artery and umbilical vein of 21 clinically normal parturients and their conceptuses. t4 levels in maternal peripheral blood did not differ significantly from t4 levels in the ivs, but were significantly higher than those detected in umbilical vein and artery (p less th ... | 1988 | 3402833 |
| thyroid hormone levels in rats exposed to alcohol during development. | maternal ingestion of alcohol appears to cause a pattern of congenital anomalies with a reduction of pre- and postnatal growth in the offspring. in order to study the possible implication of thyroid function in the effects of pre- and/or postnatal exposure to alcohol, we have studied serum thyroxine (t4) and triiodothyronine (t3) levels in rats from alcohol-fed mothers during the postnatal period (0-50 days). blood alcohol levels of ethanol-treated pregnant rats were approximately equal to 20-25 ... | 1988 | 3402908 |
| flight effects on plasma levels of free fatty acids, growth hormone and thyroid hormones in homing pigeons. | significant increases in circulating levels of free fatty acids (ffa) and growth hormone (gh), were observed in homing pigeons after a flight of 48 km, lasting 60-80 min. no significant change in plasma levels of thyroxine (t4) and triiodothyronine (t3) was observed. nor was there any change in t3/t4 ratio. the increase in plasma ffa is attributed to the increased release into circulation of at least one adipokinetic hormone, gh. it may be concluded that in free sustained homing flight under nor ... | 1988 | 3402909 |
| lateral eye movements as an indication of hemispheric preference: an eeg validation study. | the hemispheric asymmetry model of lateral eye movements (lem), hypothesizing a relation between a predominance of lateral gazes to one side with a predominance of activity in the hemisphere contralateral to the preferred direction of gaze, was tested in male, right-handed subjects. during presentation of cognitive tasks (verbal synonym tasks and spatial orienting tasks) the decrease in alpha-power from a reference period to each of four activation periods (anticipation, task-presentation, first ... | 1988 | 3403338 |
| serum levels of total testosterone and sex hormone binding globulin in hypothyroid patients and normal subjects treated with incremental doses of l-t4 or l-t3. | plasma testosterone (t) and sex hormone binding globulin (shbg) were assayed in normal controls (n = 9) and hypothyroid patients (n = 17) receiving increasing doses of l-t4 (0.2 mg, 0.4 mg for 30 days), followed first by 30 days without medication and then by 30 days each of 0.05 mg l-t3 and 0.2 mg l-t3. normal male controls showed a significant increase in plasma t only at high doses of either l-t4 (0.4 mg) or l-t3 (0.2 mg). a small but significant increase in plasma t levels was observed in no ... | 1988 | 3403362 |
| the bacteriophage t4 insertion/substitution vector system. a method for introducing site-specific mutations into the virus chromosome. | a bacteriophage t4 insertion/substitution vector system has been developed as a means of introducing in vitro generated mutations into the t4 chromosome. the insertion/substitution vector is a 2638-base pair plasmid containing the pbr322 origin of replication and ampicillin resistance determinant, a t4 gene 23 promoter/synthetic supf trna gene fusion, and a polylinker with eight unique restriction enzyme recognition sites. a t4 chromosomal "target" dna sequence is cloned into this vector and mut ... | 1988 | 3403529 |
| tertiary initiation of replication in bacteriophage t4. deletion of the overlapping uvsy promoter/replication origin from the phage genome. | tertiary initiation of bacteriophage t4 dna replication is resistant to the rna polymerase inhibitor rifampicin and apparently involved in the activity of recombination hot spots in the t4 genome (kreuzer, k. n., and alberts, b. m. (1985) proc. natl. acad. sci. u. s. a. 82, 3345-3349). one of the origins that function by the tertiary mechanism maps at the promoter for gene uvs y. a deletion and a linker-insertion mutation in the uvsy promoter/origin region were generated by in vitro manipulation ... | 1988 | 3403530 |
| deletion analysis of bacteriophage t4 tertiary origins. a promoter sequence is required for a rifampicin-resistant replication origin. | the dna sequence requirements of two t4 tertiary replication origins have been characterized by a deletion analysis of origin-containing plasmids. maximal replication of each origin-containing plasmid required both an intact gpmota-dependent middle-mode promoter sequence and approximately 50 base pairs of the downstream region. in contrast, gpmota-dependent transcription from the origin promoter was found to be independent of the downstream region. the requirement for a promoter element within t ... | 1988 | 3403531 |
| recombination-dependent replication of plasmids during bacteriophage t4 infection. | the replication of plasmids containing fragments of the t4 genome, but no phage replication origins, was analyzed as a possible model for phage secondary (recombination-dependent) replication initiation. the replication of such plasmids after t4 infection was reduced or eliminated by mutations in several phage genes (uvsy, uvsx, 46, 59, 39, and 52) that have previously been shown to be involved in secondary initiation. a series of plasmids that collectively contain about 60 kilobase pairs of the ... | 1988 | 3403532 |
| discrepancy between intraoperative ssep's and postoperative function. case report. | the authors report a case in which midline myelotomy for the removal of a c4-t4 ependymoma was immediately followed by abolition of short-latency somatosensory evoked potentials (ssep's) in response to bilateral posterior tibial nerve (ptn) stimulation which proved irreversible intraoperatively. subsequent intraoperative testing also revealed obliteration of median nerve (mn)-elicited responses. postoperatively, joint and vibration sensations deteriorated in the lower extremities and there was u ... | 1988 | 3404244 |
| dietary calcium and metacarpal growth in ewes. | the effects of excess dietary calcium on bone growth were quantified in 44 ewes fed ad libitum diets that contained one of four levels of dietary calcium (0.37, 0.56, 1.13 and 1.80%) and 0.42% phosphorus. animals were slaughtered at one of six ages, circulating concentrations of hormones and minerals were measured and bone morphometry was evaluated. none of the diets impaired normal bone growth of the metacarpal as evaluated by overall length, cortical index and growth plate width. circulating p ... | 1988 | 3404288 |
| elevated environmental temperature alters the responses of the reproductive and thyroid axes of female syrian hamsters to afternoon melatonin injections. | female syrian hamsters were kept in a light (14:10 h light:dark cycle, lights on 0600 h)- and temperature (22 or 30 degrees c)-controlled room; some groups were treated with an afternoon s.c. injection of melatonin (6.25, 12.5, or 25 micrograms/day) for 11 or 14 weeks. the melatonin-induced suppression of the reproductive system in hamsters maintained at 22 degrees c (as measured by vaginal cycles, uterine weights, ovarian histology, and plasma and pituitary prolactin levels) was delayed if hams ... | 1988 | 3404400 |
| hydrophobic stabilization in t4 lysozyme determined directly by multiple substitutions of ile 3. | replacing the isoleucine at amino-acid position three of bacteriophage t4 lysozyme causes changes in the thermodynamic stability of the protein that are directly related to the hydrophobicity of the substituted residue. structural analysis confirms that the hydrophobic stabilization is proportional to the reduction of the surface area accessible to solvent on folding. | 1988 | 3405287 |
| morning sickness and thyroid function in normal pregnancy. | thyroid function in early normal pregnancy was evaluated with reference to morning sickness using a newly developed free thyroxine (t4) radioimmunoassay and a highly sensitive tsh immunoradiometric assay. a significant increase in serum free t4 and a decrease in serum tsh were observed in early pregnancy relative to the levels in nonpregnant controls. the increased free t4 and hcg and decreased tsh correlated with the severity of morning sickness, and these changes were especially marked in subj ... | 1988 | 3405551 |
| fast neutron radiotherapy for advanced malignant salivary gland tumors. | thirty-two patients with inoperable, recurrent, or gross residual malignant salivary gland tumors received fast neutron radiotherapy at the university of washington. eleven patients were treated with low energy neutrons alone, four received a combined photon-low energy neutron treatment regimen ("mixed beam"), and 17 were treated with high energy neutrons alone. patients treated for microscopic residual tumor after a surgical resection were excluded from this study. with a minimum follow-up peri ... | 1988 | 3406455 |
| uptake of thyroxine by the perfused rat liver: implications for the free hormone hypothesis. | to investigate the mechanism by which thyroxine (t4) in plasma enters hepatic cells, we measured the rate constants for uptake of free t4 by the perfused rat liver and for dissociation of t4 from its plasma binding proteins. quantitative autoradiography of liver lobules after perfusion with [125i]t4 indicated an apparent rat constant for removal of free t4 from the sinusoids of at least 1.1 +/- 0.2 s-1. single-pass extraction of t4 from human serum was 10.6 +/- 1.7% at physiological flow rates ( ... | 1988 | 3407767 |
| [combined midazolam-ketamine anesthesia in traumatologic interventions. patterns of endocrine reactions]. | for anesthesia, ataranalgesic combinations of benzodiazepines and ketamine have been reported to be advantageous alternatives to inhalation agents or high-dose opioids. in this study, the influence of midazolam-ketamine-n2o/o2 anesthesia on the endocrine metabolic response of patients during the course of reconstructive orthopedic surgery (n = 8) was investigated. methods. the dosage of anesthetic agents was calculated according to body weight. thus, the amount of ketamine given in young adults ... | 1988 | 3407894 |
| retrospective dna analysis of t3/t4 breast carcinoma using cytophotometry and flow cytometry. a comparative study with prognostic evaluation. | tumor cells from 72 patients with advanced breast carcinoma (t3/t4) were analyzed for their dna content by cytophotometry and flow cytometry (fcm). both methods were able to subdivide the tumors into groups with different prognoses. patients with a normal/near-normal dna content in the tumor had a better prognosis than did those with aneuploid tumors. fcm measurements of dna content gave a better discrimination for both survival (p = .019) and disease-free survival (p = .059) than did cytophotom ... | 1988 | 3408544 |
| characteristics of postnatally induced alterations in thyroxine 5'- and 5-monodeiodinating activities in several pig tissues. | changes in the in vitro hepatic, kidney, skeletal muscle, heart and brain 5'- and 5-monodeiodinase activities were studied in piglets aged 4-12 h and 3, 7, 14, 21, and 42 days. as compared to the adult pig, the hepatic conversion of thyroxine (t4) to 3,5,3'-triiodothyronine (t3) and 3,3'5'-triiodothyronine (rt3) was on average 3-5 times higher in the liver, and equal or lower in the kidney. at birth, the liver generated about 66% of t3 and 75% of rt3, the other tissues the rest. increasing contr ... | 1988 | 3408752 |
| 32p-adduct assay: comparative recoveries of structurally diverse dna adducts in the various enhancement procedures. | a 32p-adduct assay for the measurement of low levels (1 adduct per 10(7) nucleotides) of binding of carcinogens to dna has been reported previously. in this procedure, dna is enzymatically hydrolyzed to 3'-monophosphates of normal nucleosides and adducts, which are 5'-32p-labeled by t4 polynucleotide kinase and [gamma-32p]atp. labeled adducts are resolved by tlc. enrichment of adducts by extraction in 1-butanol [gupta, r.c. (1985) cancer res., 45, 5656] or digestion with nuclease p1 [reddy, m.v. ... | 1988 | 3409474 |
| chicken hepatic metabolism in vitro. protein and energy relations in the broiler chicken--vi. effect of dietary protein and energy restrictions on in vitro carbohydrate and lipid metabolism and metabolic hormone profiles. | 1. ross male broiler chicks growing from 14 to 28 days of age were fed 14 and 20% protein diets (4 kcal day-1/body wt0.66) or 20 and 28% protein diets (2.8 kcal day-1/body wt0.66) in a 2 x 2 factorial arrangement to determine the effects of protein and energy intakes on in vitro lipogenesis (ivl) and net glucose production (ngp). plasma concentrations of insulin, glucagon, thyroid hormones (t3 and t4) and somatomedin-c (sm-c) were estimated by radioimmunoassay. 2. there was a significant (p less ... | 1988 | 3409661 |
| a comparison of thyroid function in dba/2j and c57bl/6j mice. | dba/2j mice exhibit audiogenic seizure susceptibility (agss) and lower electroshock seizure thresholds compared with c57bl/6j mice. thyroid function, including thyroxine (t4), 3,5,3'-triiodothyronine (t3), and thyrotropin (tsh) concentrations, t4/t3 ratio, and iodide uptake, of dba and c57 mice were compared. thyroid function was also assessed in relation to agss and severity in dba mice. dba mice have a larger thyroidal pool of iodide due to increased iodide uptake and possibly decreased releas ... | 1988 | 3409839 |
| initiation of heteroduplex-loop repair by t4-encoded endonuclease vii in vitro. | heteroduplex dnas with single-stranded loops of 51 nt or 8 nt were constructed in vitro and used in reactions with purified endonuclease vii (endo vii) from phage t4. the enzyme makes double-strand breaks by introducing pairs of staggered nicks flanking the loops. regardless of loop-size the nicking sites map exclusively at the 3' side of the loop in the looping strand and at the 3' side of the base of the loop in the non-looping strand. the number of potential cleavage sites is small (less than ... | 1988 | 3409872 |
| the effect of indomethacin, ibuprofen and paracetamol on the trh induced tsh secretion in the rat. | 1. the response of tsh to trh and the trh content of the hypothalamus, following indomethacin, ibuprofen and paracetamol treatment, was measured in male rats. 2. daily treatment of indomethacin (3 mg/kg)) for 3 days markedly reduced t4 concentration in the serum, the trh content of the hypothalmus gland and inhibit pituitary tsh response to the low t4 level in the blood. 3. ibuprofen (12 mg/kg) and paracetamol (50 mg/kg) did not influence t4 or tsh levels of the serum nor the trh content of the ... | 1988 | 3410280 |
| short-term treatment with testosterone increases plasma 3,5,3'-triiodo-l-thyronine and hepatic l-thyroxine 5'-monodeiodinase levels in arctic charr, salvelinus alpinus. | testosterone (t), methyl testosterone (mt), and testosterone propionate (tp) (0.5 mg/100 g body wt in 40 microliter peanut oil) or peanut oil alone were injected (ip) on days 0 and 3 into immature arctic charr (salvelinus alpinus). charr were sampled on days 7 and 12 and plasma testosterone, l-thyroxine (t4), 3,5,3'-triiodo-l-thyronine (t3), and hepatic microsomal t4 5'-monodeiodinase (t4 5'd) measured. plasma androgen levels were elevated by all androgen treatments to levels similar to those ob ... | 1988 | 3410289 |
| autogenous regulation of the rega gene of bacteriophage t4: derepression of translation. | the rega gene of phage t4 encodes a translational repressor that inhibits utilization of its own mrna as well as the translation of a number of other phage-induced mrnas. in recombinant plasmids, autogenous translational repression limits production of the rega protein when the cloned structural gene is expressed under control of a strong, plasmid-borne promoter (lambda pl). we have found that a genetic fusion which places the rega ribosome binding domain in proximity to active translation leads ... | 1988 | 3410302 |
| depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (vip). | vasoactive intestinal peptide (vip) is a 28 amino acid-residue neurovascular and gut peptide with a number of important biological activities. recent in vitro studies suggest an immunomodulatory (depressant) role for vip. in the present in vivo studies, employing the hall and morris sheep lymphocyte traffic model, acute infusions of vip into cannulated afferent lymphatics of popliteal lymph nodes produced prompt and marked depressions in the output of both small recirculating and blast lymphocyt ... | 1988 | 3410493 |
| [nasopharyngeal cancer in childhood]. | a retrospective study of 24 children suffering from nasopharyngeal cancer (npc) during the years 1974-1983 is reported. the diagnosis was delayed because of the primary tumor site and difficulty in examination. cervical lymph node enlargement (83.3%) was the commonest presenting symptom. the diagnosis was usually confirmed by cervical lymph node biopsy. boys were affected 1.6 times more frequently than girls. in all, 91% of our cases had an anaplastic carcinoma, and 70% were in stage t3 or t4. s ... | 1988 | 3410750 |
| [report of experiences (1974-1986) in classification and site distribution of malignant tumors of the organs of the inner nose and paranasal sinuses. a retrospective review of over 1,296 cases]. | the 4th edition of the uicc classification of the tnm system came into force on 1st january 1987. new rules have been established for the classification of maxillary sinus tumors. we have compared these to the classification system used by the ao/hno for all the sinuses and the nose. from a review of the world literature and analysis of 1296 patients registered in the years 1974 to 1986, it became clear that less than 60% of all malignant tumors of the nasal cavity and sinuses are primarily loca ... | 1988 | 3410751 |
| a radioimmunoassay for measurement of thyronine and its acetic acid analog in urine. | a sensitive and specific ria has been developed to measure thyronine (to) in urine. the ria used an anti-to antibody obtained from a rabbit immunized with a l-to-human serum albumin conjugate and [3h]to as the radioligand. the acetic acid analog of to (toac), that is the diphenyl structure with an acetic acid side-chain, cross-reacted strongly with the antibody. relative to to, it cross-reacted 160% in phosphate-buffered saline, ph 7.4, and 100% in 0.075 mol/l barbital buffer, ph 8.6, containing ... | 1988 | 3410934 |
| absence of serum thyroid hormone autoantibodies in patients chronically treated with amiodarone. | the role of iodine in the pathogenesis of thyroid hormone autoantibodies (thaa) was evaluated in a large series (n = 223) of patients submitted to chronic treatment (3-36 months) with the iodine-rich drug, amiodarone. positive anti-t3 autoantibody (abt3) tests were found only in one patient, whereas tests for anti-t4 autoantibody (abt4) were negative in all cases. likewise, the incidence of thaa in the control groups of patients with spontaneous thyroid disorders was low. the overall prevalence ... | 1988 | 3411091 |
| effect of thyroxine supplementation on the response to perfluoro-n-decanoic acid (pfda) in rats. | the effects of thyroxine (t4) supplementation on perfluoro-n-decanoic acid- (pfda) induced decreases in food consumption, body weight, and body temperature were examined. a dose-response study was carried out with 50-, 100-, 200-, or 250-micrograms/kg ip doses of t4 for 7 d prior to pfda administration, and daily dosing with t4 was continued for an additional 30 d. from this study a t4 dose of 200 micrograms/kg was chosen, and subsequent experiments were conducted with this dose. supplementation ... | 1988 | 3411633 |
| major proteins in normal human lymphocyte subpopulations separated by fluorescence-activated cell sorting and analyzed by two-dimensional gel electrophoresis. | we have compared the overall patterns of protein synthesis of normal human lymphocyte subpopulations taken from five volunteers using high resolution two-dimensional gel electrophoresis. the lymphocytes were isolated using density gradient centrifugation, labeled with subtype-specific moabs, and separated to a high degree of homogeneity by facs into cd4+ helper t cells, cd8+ suppressor t cells, cd20+ b cells, and n901 (nhk-1)+ nk cells. the four lymphocyte subpopulations were labeled with [35s]m ... | 1988 | 3412027 |
| a bidirectional promoter is regulating the drosophila ras2 gene. | we isolated and delimitated the drosophila ras2 promoter region, determined its sequence and mapped the transcription units expressed in this region. the results showed that the drosophila ras2 gene is flanked by another transcription unit, which codes for two larger transcripts, 2.5 and 2.9 kb long. orientation experiments, in which sense and antisense rna probes were used, revealed that both these and the ras2 transcripts are synthesized from different dna strands. thus, the flanking transcrip ... | 1988 | 3412773 |
| human repair gene restores normal pattern of preferential dna repair in repair defective cho cells. | the pattern of preferential dna repair of uv-induced pyrimidine dimers was studied in repair-deficient chinese hamster ovary (cho) cells transfected with the human excision repair gene, ercc-1. repair efficiency was measured in the active dihydrofolate reductase (dhfr) gene and in its flanking, non-transcribed sequences in three cell lines: wild type cho cells, a uv-sensitive excision deficient cho mutant, and the transfected line of the mutant carrying the expressed ercc-1 gene. the cho cells t ... | 1988 | 3412890 |
| confirmation of the reading frame of bacteriophage t4 uvsy gene. | 1988 | 3412904 | |
| the value of l-thyroxine in the supressive therapy of euthyroid nodules and in the prevention of post-thyroidectomy recurrences. | long-term l-thyroxine (l-t4) suppression therapy was applied to 133 patients with euthyroid nodular goiter (126 females/7 males) and to 148 patients (136 females/12 males) with post-thyroidectomy recurrence between the years 1980 and 1986. the results are interpreted as "complete success" if the nodule disappeared, "partial success" if it became smaller, "late unresponsiveness" if the nodule first decreased then increased in volume and "unresponsiveness" when it did not change. in the group of e ... | 1988 | 3413442 |
| sodium ipodate in the treatment of toxic diffuse goiter. short-term and long-term effects on thyrotoxicosis. | iodinated radiocontrast medication has been successful in the treatment of thyrotoxicosis when used for short periods up to 21 days, but experience with long-term use is lacking. in the first part of this study, a group of seven patients each taking 1.5 g. sodium ipodate daily was observed for 21 days and compared to a similar group of seven thyrotoxic patients taking 400 mg. propylthiouracil (ptu) daily. sodium ipodate brought about a more significant decrease in serum total t3 and t4 levels, a ... | 1988 | 3413443 |
| potentiation of 1,1-dichloroethylene hepatotoxicity: comparative effects of hyperthyroidism and fasting. | the responses of fed, fasted, and hyperthyroid (t4) sprague-dawley male rats to 50 mg 1,1-dichloroethylene (1,1-dce)/kg were compared. hyperthyroid rats received three sc injections of thyroxine (100 micrograms/100 g) at 48-hr intervals; all other rats were sham-injected. 1,1-dce was given po in mineral oil 24 hr after the last t4 dose; controls received only mineral oil. animals were killed at 2, 4, and 8 hr. liver gsh contents were lowered about 55% by both fasting and t4 while gsh transferase ... | 1988 | 3413796 |
| trypanosome-induced depression of plasma thyroxine. levels in prepubertal and adult female goats. | changes in plasma t4 levels were investigated in prepubertal and adult female goats during the course of an experimental trypanosoma congolense infection. a significant decline in the t4 levels was observed within 1 week of trypanosome challenge. the levels remained low up to the end of the 7th weeks when prepubertal goats received a trypanocidal treatment, whereafter the values started to rise to normal pre-infection values. the post-infection plasma t4 values in the untreated adult goats did n ... | 1988 | 3414317 |
| epidural blood flow and regression of sensory analgesia during continuous postoperative epidural infusion of bupivacaine. | epidural blood flow was measured in seven patients undergoing elective abdominal surgery during combined lumbar epidural and general anesthesia. after an initial dose of 20 ml plain bupivacaine 0.5%, a continuous epidural infusion of bupivacaine 0.5% (8 ml/hr) was given for 16 hours for postoperative pain relief. the epidural blood flow was measured by a local 133xe clearance technique in which 15-35 mbq 133xe diluted in 1 ml saline was injected through the epidural catheter on the day before su ... | 1988 | 3414989 |
| prognostic factors in locally advanced breast cancer (t3, t4) with special reference to tumor cell dna content. | the prognostic value of dna analysis was studied retrospectively in 91 patients with locally advanced breast cancer (t3, t4) and a follow-up time of 3-7 years. tumor cell dna analysis was performed by static cytometry on aspiration biopsy specimens in 42 cases and on tissue sections in 49 cases. the tumors were classified as euploid or aneuploid. sixty-four percent of the tumors were aneuploid. dna pattern correlated significantly to histologic grade and axillary perinodal growth and also to sur ... | 1988 | 3415850 |
| spinal origin of sympathetic preganglionic neurons in the rat. | the segmental distribution of sympathetic preganglionic neurons (spns) and dorsal root ganglion cells (drgs) was studied after fluoro-gold injections into the major sympathetic ganglia and adrenal gland in rats. a quantitative assessment of the segmental and nuclear locations was made. four general patterns of innervation were apparent: (1) a large number of spns (1000-2000/ganglion) innervate the sympathetic ganglia which control head or thoracic organs and a relatively small number of spns (10 ... | 1988 | 3416186 |
| the effects of previous severe exercise upon the respiratory vco2/vo2 exchange ratio as a predictor of maximum oxygen uptake. | the present study examined the effect of previous severe exercise upon (i) respiratory exchange during maximal exercise, and (ii) the respiratory vco2/vo2 exchange ratio (r) as a predictor of maximum oxygen uptake (vo2max). thirteen healthy males performed a progressive treadmill test to vo2max: at rest (t1); after a 1 h run on the level treadmill at a speed corresponding 82.4 +/- 7.3% of their vo2max (t2); after 1 h recovery (t3); and after 24 h recovery (t4). respiratory gases were continuousl ... | 1988 | 3416857 |
| maturation of regenerating nerve assessed by evoked potential in the rat: hyperbolic time course. | recovery of sensory fiber excitability after sciatic nerve lesion induced by freezing was assessed by the somesthesic evoked potential (sep) in response to plantar pad electrical stimulation. sep was recorded from the s1 area through chronically implanted cortical electrodes. the p1 wave reappeared on day 22 or 23 postinjury, indicating that the axonal elongation rate ranged between 3.9 and 4.1 mm/day. p1 onset (p1o) latency decreased from 61.9 +/- 6.4 ms (sd) on postoperative day 22 to 18.8 +/- ... | 1988 | 3416982 |
| release of 3,5,3'-triiodothyronine, thyroxine and thyroglobulin from tsh-stimulated mouse thyroids in the perifusion system. | we established a perifusion system using mouse thyroid glands. in this system, tsh increased the release of t3 and t4 significantly, and the response of thyroglobulin to tsh was delayed in comparison with that of t3 and t4. | 1988 | 3416995 |
| [simultaneous radiochemotherapy of locally advanced stage t4 breast cancer]. | the local efficacy of simultaneous radiochemotherapy was tested in 17 women with 18 carcinomas of the breast in stage t4 only. treatment was conducted for a period of 6 months with 6 courses of drug therapy (a + e) coordinated simultaneously with 6 courses of radiotherapy. in 72% of the cases we found considerable (greater than 80%) or complete (100%) regression of the tumour as a result of this combined treatment. the median survival time is 35 months. | 1988 | 3417091 |
| effect of fatty acid administration on plasma thyroid hormones in the domestic fowl. | in birds a severe stress is associated with a reduction in concentrations of plasma thyroxine. studies in man and the rat have demonstrated that severe illness is associated with an increase in serum concentrations of free fatty acids, notably oleic acid, and that they are associated with a reduction in concentrations of serum thyroxine (t4) and/or triiodothyronine (t3). since stress is associated with increased fatty acids in birds, we have, in the present study, examined the role of oleic acid ... | 1988 | 3417114 |
| lasting remissions in patients treated for graves' hyperthyroidism with propranolol alone: a pattern of spontaneous evolution of the disease. | twenty-six patients with graves' hyperthyroidism treated only with propranolol for 1-21 months have been followed up to 5 years. the patients were evaluated before treatment, at 15, 30, and 90 days during treatment, and then at 90-day intervals during propranolol treatment by clinical examination and measurement of serum free t3, free t4, rt3, tsh, and sex hormone-binding globulin concentrations and serum anti-thyroglobulin, antithyroid microsomal, antithyroid peroxidase, and thyroid-stimulating ... | 1988 | 3417846 |
| drug and fatty acid effects on serum thyroid hormone binding. | we directly compared the competitor potency for serum t4 binding of 11 nonsteroidal antiinflammatory drugs; the diuretics furosemide, ethacrynic acid, and bumetanide; diphenylhydantoin; the cholecystographic contrast agents iopanoate and ipodate; and six long-chain nonesterified fatty acids (nefa) using equilibrium dialysis. to avoid artefacts that occur in competitor studies with diluted serum or isolated binding proteins, we used undiluted normal serum, with drugs added at concentrations that ... | 1988 | 3417847 |
| the use of thermally activated tritium atoms for structural-biological investigations: the topography of the tmv protein-accessible surface of the virus. | thermally activated tritium atoms were used for studying the topography of the tmv protein-accessible surface of the virus. the accessibility profile of amino acid residues in a protein polypeptide chain was determined from data on the intramolecular distribution of a tritium label in the tmv protein. it was shown that tryptic peptides t3, t4, t12, the n-terminal region of peptide t1 and the proximal tryptic peptide t8 (located 20 to 25 a (1 a = 0.1 nm) from the viral axis) are accessible to tri ... | 1988 | 3418711 |
| immunoradiometric assay for basal thyroid-stimulating hormone levels: strategy for the management of thyroxine replacement. | basal levels of thyroid-stimulating hormone (tsh) as determined by a highly sensitive immunoradiometric assay (irma) were evaluated in 30 clinically euthyroid patients receiving levothyroxine (t4) replacement therapy for primary hypothyroidism. in each patient, the serum tsh level had been normal as determined by conventional tsh radioimmunoassay while the patient had been receiving a constant dosage of t4 for at least three months before the study. correlation of the tsh levels by irma with the ... | 1988 | 3420444 |
| cytologic diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma in sputum. | a prospective study of the value of sputum cytology in the diagnosis of squamous cell carcinoma of the larynx and hypopharynx is reported. sputum cytology established the diagnosis in 63.5% of the patients with laryngeal lesions and in 77.4% of the patients with hypopharyngeal lesions. in laryngeal cancer, a positive diagnosis by sputum cytology was related to clinical t factors (according to the tnm classification): while only 29.4% of t1 lesions were positively detected by sputum cytology, 63. ... | 1988 | 3421013 |
| effect of postweaning thyroid status on endocrine and adipose development in rats. | we previously reported that 6 wk after thyroidectomy, rat fat cell diameter and number were 86 and 32% of values in age-matched controls. this study aims to 1) determine the time course of these changes and of parallel changes in the levels of several hormones known to participate in adipose differentiation and 2) try to normalize the altered cellularity with thyroxine (t4) treatment. rats were thyroidectomized (t) or sham-operated and studied 2, 5, or 6 wk later. at 5 wk some t rats received l- ... | 1988 | 3421326 |
| interaction of 2,4-diaminopyridine with cholinesterase inhibitors. | the interaction between 2,4 diaminopyridine (2,4-dap) and neostigmine or edrophonium was studied in vivo in the rat sciatic nerve-tibialis anterior muscle preparation using the constant infusion technique of pancuronium. the ed50 value (dose of drug which produces 50% antagonism) decreased from 17 to 7 micrograms/kg with neostigmine and from 70 to 20 micrograms/kg with edrofonium, when these 2 compounds were co-administered with 40 micrograms/kg 2,4-dap. the ed50 value of 2,4-dap decreased from ... | 1988 | 3421780 |
| structural conservation among three homologous introns of bacteriophage t4 and the group i introns of eukaryotes. | three group i introns of bacteriophage t4 have been compared with respect to their sequence and structural properties. the introns include the td intervening sequence, as well as the two newly described introns in the nrdb and suny genes of t4. the t4 introns are very closely related, containing phylogenetically conserved sequence elements that allow them to be folded into a core structure that is characteristic of eukaryotic group ia introns. similarities extend outward to the exon sequences su ... | 1988 | 3422485 |
| reversibility of strand invasion promoted by reca protein and its inhibition by escherichia coli single-stranded dna-binding protein or phage t4 gene 32 protein. | when reca protein promotes homologous pairing and strand exchange involving circular single strands and linear duplex dna, the protein first polymerizes on the single-stranded dna to form a nucleoprotein filament which then binds naked duplex dna to form nucleoprotein networks, the existence of which is independent of homology, but requires the continued presence of reca protein (tsang, s. s., chow, s. a., and radding, c. m. (1985) biochemistry 24, 3226-3232). further experiments revealed that w ... | 1988 | 3275638 |
| two-week stimulation or blockade of the sympathetic nervous system in man: influence on body weight, body composition, and twenty four-hour energy expenditure. | seven lean healthy young men were studied for 6 weeks during exposure to pharmacologic inhibition or stimulation of the sympathetic nervous system. for a period of 2 weeks their beta-adrenergic receptors were either blocked with propranolol hydrochloride (160 mg/d) or stimulated with terbutaline sulphate (15 mg/d). after a further 2 weeks of placebo administration (500 mg lactose/d), the subjects crossed over to the drug they had not been taking at the beginning of the experiment for another 14 ... | 1988 | 3275861 |
| lymphocyte subpopulation monitoring in cyclosporine-treated patients following heart transplantation. | circulating lymphocyte subpopulations were studied in 18 consecutive patients treated with cyclosporine-prednisone immunosuppression during the first month following heart transplantation. eleven patients showed no evidence of graft rejection. there were eight episodes of acute rejection demonstrated at endomyocardial biopsy in 7 patients. three patients were treated with corticosteroids, 3 were treated with rabbit antithymocyte globulin (ratg), and 1 died before treatment (early mortality: 5.6% ... | 1988 | 3276276 |
| clinical evaluation of tumor characteristics predisposing serum thyroglobulin to be undetectable in patients with differentiated thyroid cancer. | this study delineates tumor characteristics which predispose serum thyroglobulin (tg) to be undetectable in patients in spite of persistent or recurrent differentiated thyroid cancer. three hundred seventy four thyroid carcinoma patients with completed thyroid ablation were investigated by means of conventional diagnostic procedures (131 iodine total-body scan, x-ray, tg determination) and, in addition, with high-resolution sonographic study of the neck. sensitivity of tg for the detection of me ... | 1988 | 3276396 |
| disulfide bonds and thermal stability in t4 lysozyme. | disulfide bonds are thought to serve a stabilizing role in extracellular globular proteins, but little is known about the modes of stabilization or their mechanisms. thermodynamic data presented here demonstrate that an engineered 3-97 disulfide bond previously shown to stabilize t4 lysozyme in vitro against irreversible thermal inactivation also stabilizes the molecule against reversible thermal unfolding. in this paper, we explore the relationship between the disulfide's thermodynamic contribu ... | 1988 | 3277175 |
| the human immunodeficiency virus: infectivity and mechanisms of pathogenesis. | infection with the human immunodeficiency virus (hiv) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer t lymphocytes that express the receptor for the virus (the cd4 molecule). hiv also has tropism for the brain leading to neuropsychiatric abnormalities. besides inducing cell death, hiv can interfere with t4 cell function by various mechanisms. the monocyte serves as a reservoir for hiv and is relatively refractory to its cytopathic effects. hi ... | 1988 | 3277274 |
| replacements of pro86 in phage t4 lysozyme extend an alpha-helix but do not alter protein stability. | to investigate the relation between protein stability and the predicted stabilities of individual secondary structural elements, residue pro86 in an alpha-helix in phage t4 lysozyme was replaced by ten different amino acids. the x-ray crystal structures of seven of the mutant lysozymes were determined at high resolution. in each case, replacement of the proline resulted in the formation of an extended alpha-helix. this involves a large conformational change in residues 81 to 83 and smaller shift ... | 1988 | 3277275 |
| transcription stimulates recombination. ii. generalized transduction of escherichia coli by phages t1 and t4. | phage mu was inserted in the trpe gene of one donor escherichia coli strain and in the lac promoter of another. strains with mu prophage mutations which permitted transcription of genes whose transcription had been polarly blocked by the mu insertion were isolated and called "bypass" strains. the transducing phages t1am, and t1am,st, and, in one instance, t4gt7 were grown on both the bypass and the original strains. after growth on the bypass strains transducing phages were able to transduce trp ... | 1988 | 3277329 |
| evaluation of phenotype of mononuclear host cells isolated from primary tumour and peripheral blood of patients with laryngeal carcinoma. | mononuclear host cells isolated from primary laryngeal carcinoma were assessed by means of indirect immunofluorescence with a panel of monoclonal antibodies against various lymphocyte subsets and macrophages. tumours of various staging groups were examined in parallel with cells isolated from patient and donor peripheral blood (pbl). it was found that percentage values of cells bearing t3 and t4 phenotype were reduced both in tumour infiltrating cells (tic) and in pbl population. the fall in t4+ ... | 1988 | 3277340 |
| resolution of model holliday junctions by yeast endonuclease is dependent upon homologous dna sequences. | holliday junctions, in which two double-stranded dna molecules are linked by single-stranded crossovers, are thought to be central intermediates in genetic recombination. we report here the in vitro specificity of a yeast endonuclease for structures analogous to holliday junctions. plasmids that extrude inverted repeat sequences into cruciform junctions are cleaved by the introduction of nicks into strands of like polarity, approximately 4-8 nucleotides from the base of the junction. in all case ... | 1988 | 3277721 |
| roles of the escherichia coli heat shock sigma factor 32 in early and late gene expression of bacteriophage t4. | we have analyzed early and late t4 gene expression at the levels of transcription and translation in rpoh+ (sigma 32+) and rpoh mutant cells infected under heat shock conditions. we found, as expected, that escherichia coli cells must be adapted before infection to high temperature by the heat shock response to allow early t4 transcription, subsequent late gene expression, and progeny production at 42 degrees c. unexpectedly, we found in addition that when rpoh mutant (sigma 32 mutant) cells wer ... | 1988 | 3277955 |
| the immunoarchitecture of the normal human lacrimal gland. relevancy for understanding pathologic conditions. | to delineate the immunoarchitecture of the normal human lacrimal gland, monoclonal antibodies that detect b- and t-lymphocyte, macrophage, and dendritic cell lineage, subset, and differentiation-associated antigens were used in combination with highly sensitive tissue-section immunoperoxidase techniques. plasma cells, identified with monoclonal antibody okt10, represented the predominant mononuclear cell population, accounting for 53.9% of all mononuclear cells present. a qualitative study of pl ... | 1988 | 3278257 |
| epidural versus combined spinal epidural block for cesarean section. | in a controlled study a single segment combined spinal epidural (cse) block was compared with epidural block for cesarean section. thirty healthy parturients were randomly divided into two groups. in both groups a t4 block was aimed at. bupivacaine was used to provide analgesia in both groups. all patients receiving cse block had good to excellent analgesia, while 11 patients (74%) receiving epidural block had similar pain relief. this was reflected in the requirement for additional analgesics, ... | 1988 | 3278500 |
| thyroid function in the elderly. | many differences in thyroid function exist between elderly and younger populations. although serum t4 levels probably do not change with age, serum t3 levels appear to decline. hyperthyroidism in the geriatric population may be atypical and is characterized by anorexia and constipation. the pulse rate is often slower than in younger patients. apathetic hyperthyroidism mainly occurs in older patients. the cause of hyperthyroidism is usually toxic multinodular goiter. isolated t3 or t4 elevations ... | 1988 | 3278788 |
| [therapy of endemic goiter with levothyroxine and iodide. a multicenter study]. | 74 patients suffering from diffuse endemic goitre and with peripheric euthyrotic metabolism were treated for 6 months either with 150 micrograms levothyroxine (t4) daily (group i, n = 35), or with a combination of 100 micrograms levothyroxine and 130.8 micrograms potassium iodide (corresponding to 100 micrograms iodide) daily (group ii, n = 39). this was followed in each case by a 3-month prophylactic administration of 100 micrograms iodide daily. after 3, 6 and 9 months the reduction of the goi ... | 1988 | 3278876 |
| uv mutagenesis in e. coli with excision repair initiated by uvrabc or denv gene products. | mutation frequency responses produced by ultraviolet light are compared in 4 closely related strains of e. coli b/r having the same tyr(oc) allele and different excision-repair capabilities: uvr+ (excision repair initiated by wild-type uvrabc activity), uvra (excision repair defective), uvra/pdenv-7 (excision repair initiated by endonuclease v of bacteriophage t4, denv activity), and uvr+/pdenv-7 (excision repair initiated by uvrabc and denv activities). the production of tyr+ prototrophic mutan ... | 1988 | 3279310 |
| long-term prospective trial of low-dose methotrexate in rheumatoid arthritis. | twenty-six patients with severe rheumatoid arthritis who had completed a randomized crossover trial of methotrexate elected to continue to receive the drug in a long-term prospective study. at 36 months, 16 patients remained in the study. over this period of time, significant improvement was noted in the number of painful and swollen joints, physician and patient global assessments, erythrocyte sedimentation rate, and prednisone dose. adverse reactions occurred in 16 patients (62%), including na ... | 1988 | 3279962 |
| immunohistological analysis of experimental gingivitis in humans. | immunohistological analysis of experimental gingivitis in humans was carried out to provide a baseline for the study of immunoregulatory mechanisms in chronic inflammatory periodontal disease. using a panel of monoclonal antibodies in an avidin biotin immunoperoxidase technique, t cell subsets were identified and the pattern of class ii major histocompatibility complex (mhc) antigens determined. twenty third-year dental students took part in the study. following the cessation of oral hygiene pro ... | 1988 | 3280178 |
| rna splicing in the t-even bacteriophage. | group 1 introns, first demonstrated in the nuclear large rrna of tetrahymena thermophila and subsequently in many yeast, fungal mitochondrial, and chloroplast precursor rnas, are capable of intron excision and exon ligation in vitro, although this process occurs much more rapidly in vivo. the discovery and characterization of a similar intron in the t4 phage thymidylate synthase gene (td) led to the finding of additional group 1 introns in other t4 genes and in genes of the related t2 and t6 pha ... | 1988 | 3280375 |
| [significance of computerized tomography and sonography in the staging (tnm classification) of cancers of the tongue and floor of the mouth]. | computerized tomography and sonography were used for pretherapeutic staging of 40 patients with cancer of the tongue. the size of the tumors and invasion of cervical lymph nodes were assessed, and both methods were compared in relation to the stage of the tumor. clinical findings were amended by diagnostic imaging in 25% of the cases. there was a distinct preponderance of advanced stages. ultrasonography proved superior to ct for t1 and t2 tumors. full assessment of t4 tumors was feasible by ct ... | 1988 | 3280526 |
| transcriptional activation of bacteriophage t4 middle promoters by the mota protein. | transcriptional activation of middle genes in bacteriophage t4 requires the phage-encoded mota protein. many middle genes are involved in deoxyribonucleotide biosynthesis and phage dna replication. in the absence of mota, the gene products that are required for dna synthesis are transcribed from other, upstream promoters. using primer extension sequencing on rna templates isolated from t4 mota+ and mota- infected cells, we have characterized 14 mota-dependent transcripts. the t4 middle promoters ... | 1988 | 3280803 |
| nucleotide and deduced amino acid sequence of stp: the bacteriophage t4 anticodon nuclease gene. | pre-existing host trnas are reprocessed during bacteriophage t4 infection of certain escherichia coli strains. in this pathway, trnalys is cleaved 5' to the wobble base by anticodon nuclease and is later restored in polynucleotide kinase and rna ligase reactions. anticodon nuclease depends on prr, a locus found only in host strains that restrict t4 mutants lacking polynucleotide kinase and rna ligase; and on stp, the t4 suppressor of prr restriction. stp was cloned and the nucleotide sequences o ... | 1988 | 3280805 |
| function of cloned t4 recombination genes, uvsx and uvsy, in cells of escherichia coli. | genes uvsx and uvsy of bacteriophage t4 both control genetic recombination and repair of damaged dna, and their mutant phenotypes bear a striking resemblance to each other. it has been shown recently that the uvsx gene product is analogous to the reca gene product of escherichia coli (yonesaki et al. 1985; yonesaki and minagawa 1985; formosa and alberts 1986), but the function of the uvsy gene is unknown. to obtain further insight into the function of these genes we introduced plasmidborne copie ... | 1988 | 3280947 |