Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4pecdf) in the rhesus monkey (macaca mulatta). | the toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4pecdf), a ubiquitous and acutely toxic environmental contaminant, was examined in three adult male rhesus monkeys administered a single iv dose of 34 micrograms (0.1 mumol)/kg. within 20 min, 4pecdf was eliminated from the blood and was distributed to the liver, skin, adipose, and muscle tissues. excretion occurred primarily via the feces with a minimum whole body half-life approximately 38 days. within 7-14 days after administr ... | 1988 | 3358261 |
| treatment of carcinoma of the skin with bone and/or cartilage involvement. | from 1956 to 1978, 23 patients with stage t4 carcinoma of the skin of the head and neck were treated with radiotherapy (rt). there were nine patients with cancer of the skin of the nose, eight with tumors of the pinna, and six with lesions of the eyelids. basal cell carcinoma (bcc) was seen in 61%, squamous cell carcinoma (scc) in 26%, and 13% of patients had tumors with bcc and scc features. the majority of patients had large tumors. less than one-third of patients had smaller lesions, whereas ... | 1988 | 3358361 |
| [salvage treatment with a view to recovery in a group of 1700 otorhinolaryngologic cancers treated by radiotherapy]. | results after radiotherapy, alone or combined with surgery, applied prior to 1982 in 1700 patients with localized ent tumors showed 669 (39%) of t and/or n failures and isolated second ent localizations. therapeutic recovery operation was performed in 263 of these 669 cases (39%). for the 324 cases of isolated t failures, 31% had recovery treatment, with a level varying between 15% for base of tongue and 55% for laryngeal tumors. frequency of treatments varied with initial tnm (18% for t3-t4 and ... | 1988 | 3358603 |
| thyroid hormones inhibit the ca2+ calmodulin-induced activation of myosin light chain kinase. | l-thyroxine (t4) and l-triiodothyronine (t3) specifically, inhibited myosin light chain kinase (mlc-kinase) from various tissues whereas inhibitory effects of t4 and t3 on other protein kinases such as protein kinase c, camp-dependent protein kinase, casein kinase i, casein kinase ii and calmodulin kinase ii were much weaker. t4 was a more potent inhibitor of mlc-kinase than t3. kinetic studies showed that t4 behaved as a competitive inhibitor of mlc-kinase toward calmodulin (cam) and that ki va ... | 1988 | 3358764 |
| thyroid hormone regulation of heme synthesis in rat liver. | thyroid hormone alters the rate of heme degradation and the levels of cytochrome p450 in rat liver. these studies report the effects of thyroid status on the activity of hepatic delta-aminolevulinate synthase (alas), the initial and rate-limiting enzyme in heme synthesis. thyroidectomized male sprague-dawley rats received sc injections of diluent or hormones. t3 was found to stimulate alas activity in the liver in doses which rendered the animals euthyroid (0.3 microgram/100 g bw.day). higher do ... | 1988 | 3359971 |
| evidence for the presence of nuclear 3,5,3'-triiodothyronine receptors in secondary cultures of pure rat oligodendrocytes. | it has been reported that oligodendrocytes do not contain nuclear t3 receptors, which is in apparent contradiction with the well-known effects of thyroid hormones on myelination. in this study we have reexamined the presence of receptors in this cell population, using pure rat oligodendrocyte cultures. t3 binding was also studied with the use of pure rat astrocytes as well as in mixed neuronal-glial cultures. the latter are mainly neuronal during the first days in culture and essentially glial t ... | 1988 | 3359982 |
| human dna polymerase alpha gene expression is cell proliferation dependent and its primary structure is similar to both prokaryotic and eukaryotic replicative dna polymerases. | we have isolated cdna clones encoding the human dna polymerase alpha catalytic polypeptide. studies of the human dna polymerase alpha steady-state mrna levels in quiescent cells stimulated to proliferate, or normal cells compared to transformed cells, demonstrate that the polymerase alpha mrna, like its enzymatic activity and de novo protein synthesis, positively correlates with cell proliferation and transformation. analysis of the deduced 1462-amino-acid sequence reveals six regions of strikin ... | 1988 | 3359994 |
| presence of iodothyronines in the yolk of the hen's egg. | thyroxine (t4), 3,5,3'-triiodothyronine (t3) and 3,3',5-triiodothyronine (rt3) were determined in the yolk and white of the hen's egg and in the oocytes at various stages of development. for this purpose we have utilized the property of 0.08 n naoh both to dilute the yolk or white and to extract and bind iodothyronines by strong alkaline sephadex g-25. no iodothyronines were detected in the egg white. the total levels of t4 and t3/per 100 mg of yolk increased gradually with increased weight of o ... | 1988 | 3360292 |
| thyroid hormone resistance in hibernating ground squirrels, spermophilus richardsoni. i. increased binding of triiodo-l-thyronine and l-thyroxine by serum proteins. | thyroid function was examined during the annual cycle of richardson's ground squirrel, spermophilus richardsoni. a number of facets were measured to facilitate comparison of thyroid function in active, dormant, and aroused animals. this report discusses changes in the serum thyroid hormone and binding as assessed by radioimmunoassay, equilibrium dialysis, and competitive binding assays. during the hibernation phase (both dormant and aroused), total serum t3 (trioodo-l-thyronine) and t4 (l-thyrox ... | 1988 | 3360293 |
| thyroid hormones, testosterone, and estradiol-17 beta in plasma of epomops franqueti (tomes, 1860) (chiroptera) in the rain forest of the equator. | using japanese catching nets a total of 77 males and 37 females of the fruit eating bat epomops franqueti (megachyroptera) were captured during a period of 1 year around kisangani (zaïre). adult males with white epaulets weighing 143 +/- 3.6 g (18) had their testes present in the scrotum and higher plasma concentrations of thyroxine (t4) and testosterone than adult males without epaulets and with abdominal testes (weight 107.5 +/- 2.0 g (39)) or juveniles (72.7 +/- 2.8 g (20)). mean embryo weigh ... | 1988 | 3360295 |
| the influence of short-term 17 beta-estradiol treatment on plasma t3 levels and in vitro hepatic t4 5'-monodeiodinase activity in immature rainbow trout, salmo gairdneri. | to determine the effects of 17 beta-estradiol (e2) on aspects of thyroid function, immature rainbow trout were intraperitoneally injected with estradiol benzoate (0.5 mg/100 g) on days 0 and 3 and sampled on days 7 and 12. this protocol created plasma e2 concentrations during the first 7 days comparable to those during naturally induced vitellogenesis. control trout received peanut oil alone. plasma levels of 3,5,3'-triiodothyronine (t3) were significantly depressed on day 7 but returned to leve ... | 1988 | 3360299 |
| limited external beam and interstitial 192iridium irradiation in the treatment of carcinoma of the base of the tongue: a ten year experience. | a total of 70 patients with histologically proven diagnosis of carcinoma of the base of the tongue were treated with primary irradiation between may 1974 through april 1984. fifty-eight (83%) of these patients had locally advanced tumors (stage t3, t4, n2, n3). fifty-one of the 70 (73%) patients had clinically palpable neck nodes at first presentation. all patients received a combination of external and interstitial irradiation. the dose of external irradiation was limited to 45-50 gy over 4 1/2 ... | 1988 | 3360653 |
| effects of hydrated water on protein unfolding. | the conformational stability of a protein in aqueous solution is described in terms of the thermodynamic properties such as unfolding gibbs free energy, which is the difference in the free energy (gibbs function) between the native and random conformations in solution. the properties are composed of two contributions, one from enthalpy due to intramolecular interactions among constituent atoms and chain entropy of the backbone and side chains, and the other from the hydrated water around a prote ... | 1988 | 3360751 |
| analysis of photoaffinity label derivatives to probe thyroid hormone receptor in human fibroblasts, gh1 cells, and soluble receptor preparations. | the regulation of growth hormone gene expression by thyroid hormone in cultured gh1 cells is mediated by a chromatin-associated receptor. we have previously described a photoaffinity label derivative of 3,5,3'-triiodo-l-thyronine (l-t3) in which the alanine side chain was modified to form n-2-diazo-3,3,3-trifluoropropionyl-l-t3 (l-[125i]t3-pal). on exposure to 254 nm uv light, l-[125i]t3-pal generates a carbene which covalently modifies two thyroid hormone receptor forms in intact gh1 cells; an ... | 1988 | 3360797 |
| dose-response relationship between thyroid hormone and growth velocity in cynomolgus monkeys. | to investigate the dose-response relationship between thyroid hormone and linear growth, we studied 10 castrated prepubertal cynomolgus monkeys. hypothyroidism was induced by administration of methimazole (0.0125% in drinking water) and was confirmed by high serum tsh levels (greater than 40 mu/l) in all animals. subsequently, each animal received 1, 2, 4, or 8 micrograms/kg.day t4, im, for 9 weeks. the sequence of t4 doses was random, and 6 weeks elapsed between successive t4 doses. serum t4, t ... | 1988 | 3360894 |
| autonomous growth, but not autonomous function, in embryonic human thyroids: a clue to understanding autonomous goiter growth? | thyroid glands from six 8- to 10-week-old fetuses obtained at the time of legal abortion were cryopreserved in liquid nitrogen and transplanted into nude nu/nu mice. histological and autoradiographic studies of the grafts labeled with [3h]thymidine and [125i]iodine showed proliferation and functional differentiation of the fetal thyroid tissue. despite t4-mediated suppression of host tsh secretion, up to 36% of the follicular cell nuclei incorporated the thymidine label, reflecting autonomous pr ... | 1988 | 3360903 |
| canine model for surgical correction of chronic venous hypertension. | a chronic model of venous hypertension was created by iliofemoral venous ligation in the left hindlimb of eight greyhounds (right limb control). prior to ligation, immediately postligation (t0), and at 2, 4, 6, and 15 weeks postligation (t2-t15), bilateral hindlimb venous pressures were measured at rest. at t2-t15, exercise pressures were measured for 5 min after hindlimb muscle contraction induced under sedation by tetanic (20 sec, 50 hz, 8 ma) stimulus (s30-s300 sec). resting and exercise pres ... | 1988 | 3361883 |
| [predicting the recurrence of thyrotoxicosis after iodine radioisotope therapy of diffuse toxic goiter]. | prediction of a recurrence of thyrotoxicosis during radioiodine therapy of patients with diffuse toxic goiter (dtg) is a pressing problem of everyday treatment of such patients. altogether 43 dtg patients were investigated during 12-18 mos. after 131i therapy with the determination of t4, t3, btsh, delta tsh in the trh test, peripheral blood rosette forming (rfc), migration index (mi) in the leucocyte migration inhibition reaction, and serum immunoglobulins (iga, m, g). changes in the immunologi ... | 1988 | 3362805 |
| radical prostato-cystectomy for infiltrating bladder carcinoma using a combined abdomino-perineal approach. | radical abdomino-perineal cystectomy was used in 23 pts with tis to t4 bladder tumors, 12 of whom had previously been submitted to radical radiotherapy (salvage cystectomy). the perineal approach greatly facilitated the prostatic dissection in 10 cases, in which it was considered extremely hazardous from the abdomen. there were two post-operative deaths from acute myocardial infection in patients over 70. prolonged drainage of the perineal wound occurred in four pts. abdomino-perineal cystectomy ... | 1988 | 3362889 |
| preoperative chemotherapy in t3-t4 nx mo bladder cancer with cisplatinum and methotrexate. | 1988 | 3362906 | |
| squamous cell carcinoma of the pharyngeal wall treated with irradiation. | this is an analysis of 74 patients with 75 squamous cell carcinomas of the pharyngeal wall treated with radical irradiation at the university of florida between october 1964 and december 1984. all patients have a 2-year follow-up and 69% have a minimum 5-year follow-up. all patients were treated with continuous-course irradiation: 56 with once-a-day fractionation and 18 with twice-a-day fractionation. patients treated with the split-course technique are not included in this series. sixty-three p ... | 1988 | 3363168 |
| [risks of fertilization in vitro]. | the authors report the results of four ivf attempts, performed on the same couple, in 16 months, because of tubal problems. june 1985 (t1): spontaneous miscarriage after 8 weeks of amenorrhea; october 1985 (t2): negative tap; january 1986 (t3): extra-uterine pregnancy; october 1986 (t4): rejected because of "poor response" and spontaneous extra-uterine pregnancy during the same cycle. | 1988 | 3363276 |
| the structure of three bacteriophage t4 genes required for tail-tube assembly. | three different protein molecules copurify with t4 tail tubes after the tubes are released from the baseplate by guanidine hydrochloride treatment. these tube-associated proteins (taps) are the products of genes 29, 48, and 54. to further investigate the structural roles that these proteins may play in t4 tail assembly we have cloned and sequenced the genes coding for these proteins and have deduced their predicted amino acid sequences. the sequence data reveal a region of amino acid sequence si ... | 1988 | 3363870 |
| the acceleration transducer--an assessment of its precision in comparison with a force displacement transducer. | a new and simple acceleration transducer (act)-based system of neuromuscular monitoring has recently been introduced. the precision of this transducer has been evaluated as compared to a conventional force displacement transducer (fdt) in the present study. ten progressions of spontaneous recovery from atracurium-induced block with simultaneous measurements using the act on one hand and the fdt on the other were studied. five individuals undergoing elective surgery in modified neurolept anaesthe ... | 1988 | 3364149 |
| nmr studies of echinomycin bisintercalation complexes with d(a1-c2-g3-t4) and d(t1-c2-g3-a4) duplexes in aqueous solution: sequence-dependent formation of hoogsteen a1.t4 and watson--crick t1.a4 base pairs flanking the bisintercalation site. | we report on two-dimensional proton nmr studies of echinomycin complexes with the self-complementary d(a1-c2-g3-t4) and d(t1-c2-g3-a4) duplexes in aqueous solution. the exchangeable and nonexchangeable antibiotic and nucleic acid protons in the 1 echinomycin per tetranucleotide duplex complexes have been assigned from analyses of scalar coupling and distance connectivities in two-dimensional data sets recorded in h2o and d2o solution. an analysis of the intermolecular noe patterns for both compl ... | 1988 | 3365421 |
| rapid and reversible modulation of t4 (cd4) on monocytoid cells by phorbol myristate acetate: effect on hiv susceptibility. | the effect of phorbol myristate acetate (pma) on t4 (cd4) expression by monocytoid cells was studied. greater than 99% of untreated u937 and hl-60 cells expressed surface t4 as measured with a fluorescence-activated cell sorter. the percentage of t4 positive cells decreased to less than 20% after incubation with pma (10(-8) m). a decrease was observed within 15 min of pma exposure, was maximal within 1 hr, and persisted for at least 3 days in the continuous presence of pma. the susceptibility of ... | 1988 | 3365771 |
| seasonal patterns in serum levels of thyroid hormones and sex steroids in relation to photoperiod-induced changes in spawning time in rainbow trout, salmo gairdneri. | serum levels of thyroid hormones (t4 = l-thyroxine and t3 = 3,5,3'-triiodo-l-thyronine) were measured and correlated with previously published levels of 17 beta-estradiol, testosterone (t), and ca2+ (index of vitellogenin) in four groups of female trout held for 1-3 years at 8.5-9.0 degrees on a ration of 0.5% of body weight day-1 under different constant photoperiod regimes. in group 1, trout under a regimen of 18l:6d became sexually mature (sm) in april/may and then sm again in september/octob ... | 1988 | 3366356 |
| effects of thyroxine and growth hormone treatment of dairy cows on milk yield, cardiac output and mammary blood flow. | four cows received thyroxine injections (t4; 20 mg/d) and three cows received growth hormone injections (gh; 44 mg/d) for 4 d during successive 16-d experimental periods. measurement was made of milk yield, protein yield, mammary tyrosine and phenylalanine uptake, blood plasma hormone concentrations, mammary blood flow and cardiac output. milk yield increased by 25% with t4 and 21% with gh treatment. milk protein content tended to decline during t4 treatment and increase following gh treatment. ... | 1988 | 3366719 |
| effects of thyroxine and growth hormone treatment of dairy cows on mammary uptake of glucose, oxygen and other milk fat precursors. | four cows received thyroxine injections (t4; 20 mg/d) and three cows received growth hormone injections (gh, 44 mg/d) for 4 d during successive 16-d experimental periods. milk fat, lactose output, mammary uptake of glucose, oxygen and milk fat precursors were determined with each treatment. injection of t4 increased lactose yield by 25% and fat yield 42%. the injection of gh increased fat and lactose yields by 24%. both gh and t4 increased mammary glucose uptake by 35% and 45%, respectively, whi ... | 1988 | 3366720 |
| circannual oscillations of thyroxine and cholesterol levels after pinealectomy and ganglionectomy related to the weight changes of the pineal, pituitary, and thyroid glands. | circannual rhythms of thyroxine (t4) and cholesterol blood levels, as well as of pineal, pituitary and thyroid weights were compared in intact, pinealectomized (px), and ganglionectomized (gx) rats. special emphasis was put on the similarities and differences between the effect of px and of gx exerted on the neuroendocrine regulation of thyroid function. animals were kept under changing lighting schedules simulating the natural seasonal conditions (december, l:d 8:16; june, l:d 16:8; march and s ... | 1988 | 3367269 |
| long-term l-thyroxine therapy is associated with decreased hip bone density in premenopausal women. | the effect of long-term l-thyroxine (l-t4) therapy on axial skeleton bone density was studied in 31 premenopausal women; the bone densities of these women were compared with the bone densities of 31 age- and weight-matched women without thyroid or bone abnormalities. the women receiving l-t4 therapy had been receiving the medication for a minimum of five years. there was no difference in calcium intake or excretion between the l-t4-treated women and the controls. women receiving l-t4 had increas ... | 1988 | 3367489 |
| highly sensitive determination of tsh in the follow-up of tsh-suppressive therapy of patients with differentiated thyroid cancer. | basal and trh-stimulated tsh levels were determined in 72 patients with differentiated thyroid cancer on hormonal treatment, using a highly sensitive immunoradiometric assay (irmaclon, henning). 43 patients were under treatment with levothyroxine (t4), 29 patients with triiodothyronine (t3). in 33/43 patients (77%) under t4- and in 18/29 patients (62%) under t3-treatment basal tsh levels were below 0.1 mu/l and levels stimulated with 200 micrograms trh i.v. were below 0.5 mu/l. 3 patients showed ... | 1988 | 3368333 |
| [significance of basal tsh and free t3 as compared with an extended in vitro diagnosis in the understanding of functional disorders of the thyroid]. | data of 411 untreated patients undergoing thyroid investigations were stored in a data base system. three combinations of thyroidal hormone parameters were compared with respect to their clinical value. in patients with concordant basal tsh (btsh) and free t3 (ft3)-values (e.g. btsh normal and ft3 normal, btsh decreased and ft3 increased) it could be demonstrated that the predictive value of the combined evaluation of basal tsh (supersensitive) and free t3 alone (97% in normal thyroid function, ... | 1988 | 3368334 |
| alteration of radioactive iodine uptake after treatment of hyperthyroidism with iodine 131. | to determine whether a therapeutic dose of iodine 131 affects the results of 24-hour radioactive iodine uptake (raiu) testing, we reviewed records of hyperthyroid patients previously treated with 131i at michigan state university and its affiliated hospitals. we identified 26 patients who had had clinical evaluation and determination of the serum thyroxine (t4) level, triiodothyronine resin uptake (t3ru), and raiu (using 131i) within two weeks before and several months after the therapeutic dose ... | 1988 | 3368812 |
| features of squamous and adenocarcinoma in the same cell in a xenografted human transitional cell carcinoma: evidence of a common histogenesis? | ultrastructural features of squamous differentiation have been found in adenocarcinomatous cells in a xenografted line (ucru-bl-17) established in nude mice from a primary human bladder transitional cell carcinoma (grade iii, stage t4) with a tetraploid dna component. the line has been characterized by light and electron microscopy, flow cytometry and immunocytochemistry. the initial xenograft showed predominantly adenocarcinomatous differentiation with mucin secretion, whilst the subsequent pas ... | 1988 | 3369001 |
| thyroid indices in panic disorder. | the authors compared indices of thyroid function in 26 patients with panic disorder and 26 closely matched control subjects. no significant differences in t3, t4, free t4, thyrotropin, or thyroxine-binding globulin were found between the two groups. clinical and theoretical implications are discussed. | 1988 | 3369565 |
| implications for the formation of abasic sites following modification of polydeoxycytidylic acid by acrolein in vitro. | polydeoxycytidylic acid (poly dc) was incubated with excess acrolein. a nensorb 20 nucleic acid purification cartridge was used to bind the polymeric material in the poly dc/acrolein reaction mixture. the non-polymeric material eluted from this column had a uv absorbance four times higher than that of the control. the fluorescence spectrum of the eluted material did not correspond to that of unmodified cytosine. separate aliquots of the reaction mixture were digested to deoxynucleotide 3'-monoph ... | 1988 | 3370625 |
| autoantibodies to thyroxin and triiodothyronine. | two clinically euthyroid patients with multinodular goiter were found to have high "free" thyroxin (amerlex-m, amersham and coat-a-count, dpc) and triiodothyronine (amerlex-m) concentrations (ft4 and ft3, respectively). the presence of antibodies to t4 and t3 was confirmed by the finding that polyethylene glycol precipitated a far greater proportion of radioactivity when radiolabeled ft4 or ft3 analog (amerlex-m) was incubated with serum from these patients than was true for normal subjects. wit ... | 1988 | 3370794 |
| thyroid dysfunction and hypercholesterolaemia in the general population of glasgow, scotland. | as part of a screening programme for coronary heart disease risk factors, fasting plasma cholesterol was measured in 2,250 people from the east-end of glasgow. plasma thyrotropin (tsh) was measured in the 90 individuals (4% of the population studied) who had a cholesterol level greater than or equal to 8.0 mmol/l. four had unequivocal biochemical evidence of hypothyroidism-tsh greater than 34 mu/l and a low plasma thyroxine (t4) less than or equal to 45 nmol/l. a further 8 were found to have rai ... | 1988 | 3370836 |
| pharmacokinetics of propylthiouracil in children and adolescents with graves' disease in the hyperthyroid and euthyroid states. | the pharmacokinetics of propylthiouracil (ptu) was studied in 7 patients having graves' disease when they were hyperthyroid and then again when they were euthyroid. two additional euthyroid patients were also studied. the t1/2, ke, ka, apparent vd, auc and clearance were calculated. serum t3 and t4 were also measured. ptu had an immediate effect in reducing t3 levels. although there were intraindividual variations, the mean ptu elimination half-time did not change from the hyperthyroid state (1. ... | 1988 | 3371148 |
| a multicompartmental model for iodide, thyroxine, and triiodothyronine metabolism in normal and spontaneously hyperthyroid cats. | a comprehensive multicompartmental kinetic model was developed to account for the distribution and metabolism of simultaneously injected radioactive iodide (iodide*), t3 (t3*), and t4 (t4*) in six normal and seven spontaneously hyperthyroid cats. data from plasma samples (analyzed by hplc), urine, feces, and thyroid accumulation were incorporated into the model. the submodels for iodide*, t3*, and t4* all included both a fast and a slow exchange compartment connecting with the plasma compartment ... | 1988 | 3371254 |
| effect of inferior laryngeal nerve section on thyroid function in rats. | to examine the role of thyroid parasympathetic innervation in organ's function, rats subjected to inferior laryngeal nerve (iln) section were employed. this procedure decreased thyroid [3h]choline uptake by about half. bilaterally iln-sectioned rats treated with methylmercaptoimidazole for 4 days exhibited a significant impairment of the methylmercaptoimidazole-induced goitrogenic response. unilateral iln section resulted in further atrophy of the ipsilateral thyroid lobe in hypophysectomized ra ... | 1988 | 3371255 |
| melatonin increases serum insulin-like growth factor-i in male syrian hamsters. | male syrian hamsters maintained on a 14-h light, 10-h dark photoperiod were injected once daily (1-2 h before lights out) with melatonin (25 micrograms), once every other day with t4 (5 micrograms every other day), or melatonin every day plus t4 every other day. hamsters which received melatonin injections, with or without t4, had serum levels of insulin-like growth factor that were increased 2-fold. the results suggest that melatonin-induced changes in body weight are a result of long-term chan ... | 1988 | 3371258 |
| detection of messenger rnas within single hemopoietic cells by in situ hybridization on small slide areas. | in situ hybridization provides a powerful tool to detect specific mrna sequences at the cellular level. we have applied a modified in situ hybridization technique using specifically prepared regular glass microscope slides to evaluate mrna levels in cells of small samples. cells were derived from in vitro colonies or isolated by fluorescence-activated cell sorting and deposited on the slides. these slides were coated with polysiloxane, sparing small circular areas where adherent cells attach and ... | 1988 | 3371428 |
| [studies on the pituitary and thyroid function in patients with nonthyroid illnesses]. | serum thyroid hormone and tsh concentrations were determined in patients with nonthyroidal illnesses (nti) including 26 patients with chronic renal failure on hemodialysis, 15 patients with end-stage malignancy and 21 normal controls. serum tsh levels were measured by a highly sensitive immunoradiometric assay kit (ria-gnost htsh) and free-t4 levels were determined not only by both back-titration method and t4 derivative method, but also by magnesium precipitation method using equilibrium dialys ... | 1988 | 3371508 |
| endocrine changes in photostimulated willow ptarmigan (lagopus lagopus lagopus) and svalbard ptarmigan (lagopus mutus hyperboreus). | changes in plasma luteinizing hormone (lh), testosterone, thyroxine (t4), and triiodothyronine (t3) and the height of supraorbital combs were compared in captive willow ptarmigan (lagopus lagopus lagopus) and svalbard ptarmigan (lagopus mutus hyperboreus) exposed to an artificial annual cycle of daylength simulating that at 70 degrees n. plasma lh and testosterone and comb height increased more slowly in svalbard than in willow ptarmigan as daylength increased. in both species, plasma lh and tes ... | 1988 | 3371650 |
| peripheral autoregulation of thyromimetic activity in man. | this study describes an extrathyroidal mechanism for regulating serum concentration of triiodothyronine (t3) in thyroxine (t4) deficiency or excess. serum levels of t3, t4, reverse t3 (rt3), and thyrotropin were determined in two series of athyreotic patients (n = 22 and n = 16, respectively) during various doses of t4 substitution therapy. the patients were followed from the severe hypothyroid state up to the modest hyperthyroid state, induced by stepwise increasing doses of administered t4. th ... | 1988 | 3371862 |
| plasma thyrotropin, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine, and cortisol levels in blind prepubertal boys. | findings on thyroid function in blind subjects are lacking. the aim of this study was to investigate the thyroid hormonal pattern in prepubertal blind subjects. six healthy and 8 blind males, aged 7-10 yr, in tanner stage one puberty, living at institute "martuscelli" for blind young subjects, napoli, italy, were studied. each had a trh (200 micrograms) test at 08:00 h after nocturnal rest. plasma tsh, t4, t3, free t4(ft4), free t3(ft3) and cortisol (f) were measured by ria. our blind subjects s ... | 1988 | 3372956 |
| the different types of hyperthyroidism in europe. results of a prospective survey of 924 patients. | in a prospective multicentric study, 924 untreated hyperthyroid patients were investigated, coming consecutively within one year into 17 thyroid centers of 6 european countries. with the aid of clinical information, evaluation of thyroid scan and centrally assayed thyroid hormones, thyroid antibodies, tsh-binding inhibiting immunoglobulins (tbii), and urinary iodine, different types of hyperthyroidism could be shown. two types of hyperthyroidism could be defined directly: autonomous adenoma in c ... | 1988 | 3372959 |
| reappraisal of the baseline bone scan in breast cancer. | baseline staging bone scans in 1,267 consecutive women with breast cancer attending a single clinic between 1980 and 1986 were reviewed. 0.3% of patients with t1, 3% with t2, 8% with t3, 13% with t4 tumors and none of those with stage 1, 3% with stage 2, 7% with stage 3, and 47% with stage 4 disease had a positive scan due to bone metastases. two hundred eight-nine (23%) had bone scan abnormalities secondary to radiologically confirmed benign bone disease. in 20 patients, no cause for a bone sca ... | 1988 | 3373314 |
| uv-induced photoproducts of 5-methylcytosine in a dna sequence context. | in order to detect possible m5c photoproducts, highly purified rat liver dna-cytosine methyltransferase was used to specifically generate m5c with a radioactive methyl group. when these dnas were subjected to a large dose (10 kj/m2) of 254 nm or 302 nm ultraviolet light (uvb) to enhance the yield, two labeled photoproducts were detected and isolated by reverse phase hplc after formic acid hydrolysis. further studies using acetone as a triplet state sensitizer and uvb irradiation suggested that p ... | 1988 | 3375057 |
| site-directed modification of dna duplexes by chemical ligation. | the efficiency of chemical ligation method have been demonstrated by assembling a number of dna duplexes with modified sugar phosphate backbone. condensation on a tetradecanucleotide template of hexa(penta)- and undecanucleotides differing only in the terminal nucleoside residue have been performed using water-soluble carbodiimide as a condensing agent. as was shown by comparing the efficiency of chemical ligation of single-strand breaks in those duplexes, the reaction rate rises 70 or 45 times ... | 1988 | 3375071 |
| relation between lymphocyte subpopulations and pineal function in patients with early or metastatic cancer. | it has been demonstrated that melatonin and other pineal hormones play a role in the neuroendocrine control of immunity. anomalies of both pineal and immune functions have been reported in cancer. pineal and lymphocyte functions, however, have never been simultaneously evaluated in oncologic patients. this preliminary study was carried out in order to analyze the melatonin-lymphocyte relationship in human neoplasms. in a first investigation, we evaluated melatonin serum levels and lymphocyte sub ... | 1988 | 3377366 |
| influence of extradural and general anaesthesia on natural killer cell activity and lymphocyte subpopulations in patients undergoing hysterectomy. | the effect of hysterectomy was studied on natural killer (nk) cell activity, the distribution of lymphocyte subpopulations, and the endocrine stress response in 16 patients allocated to receive extradural analgesia s5-t4 (group i) or neuroleptanaesthesia (nla) (group ii). in group ii a significant decrease in nk cell activity was found after operation for at least 3 days, while surgery during extradural analgesia did not induce significant changes. the impaired nk cell activity was accompanied b ... | 1988 | 3377925 |
| unpredictability of regression of analgesia during the continuous postoperative extradural infusion of bupivacaine. | twenty-four otherwise healthy patients scheduled for elective major abdominal surgery received general anaesthesia plus lumbar extradural analgesia. a loading dose of 0.5% plain bupivacaine was given to produce sensory analgesia (pin prick) from t4 to s5 and followed by a continuous infusion of 0.5% plain bupivacaine 8 ml h-1. pain, scored on a 5-point scale, and sensory analgesia were assessed hourly for 16 h after skin incision. if sensory analgesia decreased by more than 5 segments from its p ... | 1988 | 3377927 |
| thyroid function in very preterm infants. | indices of thyroid function were measured in 108 infants born at 23-31 weeks gestation, after birth, at 24 and 72 h, and at 1, 3, 4, 5 and 6 weeks of age. this group was characterised by low serum thyroxine (t4), normal thyroid stimulating hormone (tsh), low-normal thyroid binding globulin (tbg), low free thyroxine index (fti) and low triiodothyronine (t3). the incidence of hypothyroxinaemia defined as a serum t4 value of less than 65 nmol/l was 58% after birth, increasing to 84% at 1 week, afte ... | 1988 | 3378519 |
| improvement in hplc fractionation of thyroxine-containing thyroglobulin tryptic peptides by prior accell ion-exchange column chromatography. | the isolation and purification of the peptides containing the hormonogenic tyrosyl residues in thyroglobulin is of great interest to the understanding of structure-function relationships in this iodoprotein. this is usually performed in reduced alkylated selectively hydrolyzed thyroglobulin by subsequent hplc fractionation. however, the main difficulty encountered when trying to isolate these peptides is their disproportion with respect to the total number of possible peptides (14 vs a total of ... | 1988 | 3378632 |
| deiodination of thyroid hormone by human liver. | liver is an important site for the peripheral production of t3 by outer ring deiodination (ord) of t4 as well as for the clearance of plasma rt3, which is produced by inner ring deiodination (ird) of t4 in other tissues. however, little is known about the underlying enzymatic reactions, and current concepts about thyroid hormone deiodination are largely based on studies in rat tissue. here we describe the results of detailed studies of the catalytic properties of the iodothyronine deiodinase act ... | 1988 | 3379132 |
| thyroid amyloidosis with recurrent subacute thyroiditis-like syndrome. | we studied 2 men with a subacute thyroiditis-like syndrome (stls) associated with systemic amyloidosis. both had very tender, diffuse, firm goiters, low thyroidal radioactive iodine uptake values, and increased erythrocyte sedimentation rates. glucocorticoid therapy resulted in dramatic improvement. compared to 18 patients with subacute thyroiditis, these 2 men had 1) persistence of goiter even in remission, 2) repeated exacerbation of stls, 3) pain always localized in the same site, and 4) gast ... | 1988 | 3379135 |
| binding of thyroid hormones to human plasma lipoproteins. | the binding of t4, t3, and rt3 to plasma lipoproteins was investigated in normal subjects and patients with abnormal lipoprotein metabolism. gel filtration on sepharose cl-6b demonstrated iodothyronine binding to all lipoprotein classes. in the total lipoprotein fraction (density less than 1.210 g/ml), high density lipoproteins (hdl) were the major binders, accounting for 92% of lipoprotein-bound t4, 99% of lipoprotein-bound t3, and 55% of lipoprotein-bound rt3. the estimated iodothyronine bindi ... | 1988 | 3379137 |
| neodymium:yag laser therapy for infiltrating bladder cancer. | there were 32 high risk patients with stages t2 to t4 bladder cancer treated with neodymium:yag laser irradiation to the tumor base after cautery resection between july 1981 and october 1986. all 12 patients with stage t2 disease followed for 6 to 78 months had no recurrence locally although 4 had stage t1 recurrences elsewhere in the bladder. of 14 stage t3 cancer patients 8 demonstrated tumor persistence locally but 3 were well 4 to 24 months later without local recurrence (all stage t3a) and ... | 1988 | 3379693 |
| effects of calcium antagonist diltiazem on liver calcium content and necrosis of hepatocytes in rats following treatment with ccl4. | to study the relationship between the changes in hepatocytes and calcium contents in the liver of 42 rats treated with ccl4 and the effect of a calcium antagonist diltiazem on the liver injury, we determined liver calcium content, serum alanine aminotransferase (alt), and serum levels of triiodothyronine (t3), thyroxine (t4), the t3/t4 ratio, and calcium before and 6 to 72 hr after treatment with a single oral dose of ccl4 (0.5 ml/kg) in 21 rats (group i) and in 21 rats treated with diltiazem (1 ... | 1988 | 3381007 |
| alterations in thyroidal economy in a systemic illness induced by turpentine oil injection to the rat. | injection of turpentine oil (5 microliter/g, sc) to sprague dawley rats was associated with a significant reduction in serum concentration of t4, t3 and tsh that lasted throughout 48 h of study. dialyzable fraction of t4 and resin uptake of t3 did not change for 10 h after turpentine oil injection, but were increased significantly at 24 h and 48 h. serum rt3 concentration was decreased significantly at 24 h and 48 h. the pituitary content of tsh in the experimental rat was significantly increase ... | 1988 | 3381625 |
| lacking evidence for release of thyroid hormones from circulating thyroglobulin during subtotal thyroidectomy. | the effect of subtotal thyroid resection for thyrotoxicosis on concentrations of serum thyroid hormones and thyroglobulin (tg), was determined in 10 patients during operation and the subsequent 18 days. mean serum tg responded drastically, increasing from a pre-operative value of 0.30 nmol/l to a peak value of approximately 26 nmol/l during operation followed by a gradual decline to levels lower than before surgery on day 18. mean serum total thyroxine was 114 nmol/l pre-operatively and free thy ... | 1988 | 3381633 |
| characterization of thyroid hormone receptors in human im-9 lymphocytes. | although putatively identified more than 10 years ago, thyroid hormone receptors in human tissues remain poorly characterized. as a first step towards understanding the mechanism of thyroid hormone action in man we have characterized t3 binding sites in nuclei of the human lymphoblastoid line, im-9 cells. in whole cell experiments at 37 degrees c, nuclear binding of [125i]t3 was saturable (kd 34 +/- 6 pmol/l) and of finite capacity (approximately equal to 350 sites/cell). the binding sites were ... | 1988 | 3381637 |
| 5,5'-diphenylhydantoin decreases the entry of 3,5,3'-triiodo-l-thyronine but not l-thyroxine in cultured gh-producing cells. | we determined the effect of 5,5'-diphenylhydantoin (dph) on the kinetics of t3 and t4 uptake in cultured gh-producing (gc) cells under serum-free conditions. gc cells accumulated [125i]t3 at a greater fractional rate than [125i]t4. the t 1/2 of exit of [125i]t4 and [125i]t3 previously equilibrated in gc cells was 28 min for t4 and 66 min for t3. t3 and t4 entry rates were not influenced by up to a 10,000-fold molar excess of nonradioactive t3, t4, d-t4, rt3, 3,5-t2 and diiodotyrosine. thus, entr ... | 1988 | 3381641 |
| effects on gastric emptying of thoracic epidural analgesia with morphine or bupivacaine. | the effects of thoracic epidural analgesia on gastric emptying were evaluated in healthy fasting volunteers. in ten volunteers, 4 mg of epidural morphine were injected at the t4 level, and ten volunteers received thoracic epidural analgesia with 0.5% bupivacaine, the latter causing block of the sympathetic innervation to the stomach. acetaminophen absorption was used as an indirect measure of the rate of gastric emptying. after establishment of the analgesia with bupivacaine, or 160 (110-185) mi ... | 1988 | 3382043 |
| mutation of active site residues in synthetic t4-lysozyme gene and their effect on lytic activity. | the active site amino acids (glu11 and asp20) in t4-lysozyme have been mutated to their isosteric residues gln or asn and/or acidic residues such as glu----asp or asp----glu by the oligonucleotide-replacement method. out of eight mutants so generated the mutant t4-lysozyme obtained from ptly.asp11 retains maximum amount of activity (approximately 16%), ptly.asn20 the least (0.9%) whereas ptly.gln11 lost completely. a systematic study of the active and inactive mutants thus generated supports the ... | 1988 | 3382407 |
| role of ovarian steroids in the control of moult induction in laying fowls. | 1. thirty-five warren ssl hens were selected on the basis of variation in moulting response following a force-moult at 81 weeks of age. fourteen hens were from a group which returned to layers mash ad libitum from day 9, while 21 came from a group with dietary restriction prolonged to day 28. blood samples were taken on days 23 and 36, and hormone concentrations were measured. moulting was recorded on days 0, 11, 23, 36, 52 and 68. 2. progesterone (p4) but not oestradiol (e2) inhibited moulting ... | 1988 | 3382972 |
| suckling, but not formula feeding, induces a transient hyperthyroxinemia in rat pups. | to assess the effect of breast feeding on circulating thyroid hormone levels in the suckling neonate, we examined serum concentrations of t4, t3, and rt3 by ria in 12- and 15-day-old rat pups fasted for 3 or 6 h before, at, and hourly for 3 or 4 h after suckling. in both age groups, serum t4 levels decreased significantly in response to the 6-h fast; no significant differences were observed after 3 h. t3 levels in 15-day-old (but not 12-day-old) rats were likewise significantly depressed, and rt ... | 1988 | 3383770 |
| effects of glutathione on iodothyronine 5'-deiodinase activity. | at nanomolar substrate levels, physiological concentrations (less than or equal to 5 mm) of glutathione (gsh) activate a low km iodothyronine 5'-deiodinase (i-5'd) activity in renal and hepatic microsomes, but not the low km (type ii) i-5'd in the pituitary, cerebral cortex, or brown adipose tissue. the latter enzyme as well as the type i enzyme activity at micromolar substrate concentrations required higher (greater than 10 mm) concentrations of gsh. however, gsh appeared to interact with the t ... | 1988 | 3383773 |
| effect of cortisol on the in vitro hepatic conversion of thyroxine to triiodothyronine in brook charr (salvelinus fontinalis mitchill). | in vitro studies with liver homogenates of brook charr (salvelinus fontinalis) demonstrate that the conversion of thyroxine (t4) to triiodothyronine (t3) is dependent upon temperature, ph, substrate, and homogenate concentration, supporting the hypothesis of an enzymatic hepatic t4 to t3 conversion. dithiothreitol has a marked stimulatory effect on the rate of conversion. the kinetics of the conversion, determined by lineweaver-burke analysis suggest a michaelis-menten (km) constant of 1.3 x 10( ... | 1988 | 3384310 |
| influence of marathon running on thyroid hormones. | thyroid hormones were studied in 16 well-trained male amateur runners (mean age 31.8 years) before, immediately after, and 60 min and 22 h after marathon running. free thyroxine (ft4), appraised by the free thyroxine index (ft4-i), was significantly increased immediately after and 1 h after the race compared with control values. thyroid-stimulating hormone (tsh) was significantly increased immediately after the race, returned to the control value 1 h later, and was markedly decreased 22 h after ... | 1988 | 3384517 |
| sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine following partial thyroidectomy for nontoxic nodular goiter. | the sequential changes in serum thyroglobulin (tg), thyroxine (t4), free thyroxine (ft4), triiodothyronine (t3) and thyrotropin (tsh) were evaluated in ten patients on whom partial thyroidectomy for nontoxic nodular goiter had been performed. these changes were compared with those in ten patients who underwent upper abdominal surgery (cholecystectomy) under similar anesthesia, and whose calorie and fluid intake was similar until at least 48 hours after surgery. in agreement with previous reports ... | 1988 | 3386534 |
| x-ray structure of a dna hairpin molecule. | we have solved the crystal structure of a synthetic dna hexadecanucleotide of sequence: c-g-c-g-c-g-t-t-t-t-c-g-c-g-c-g, at 2.1 a resolution, and observed that it adopts a monomeric hairpin configuration with a z-dna hexamer stem. in the t4 loop the bases stack with one another and with neighbouring molecules of the crystal, and not with base pairs of their own hexamer stem. two thymine t10 rings from different molecules stack between the c1-g16 ends of a third and a fourth hairpin helix, in a m ... | 1988 | 3386757 |
| optimization of nuclear medicine procedures for the diagnosis and management of thyroid disorders: report of a research coordination meeting held in vienna, 15-17 december 1986 under the auspices of the international atomic energy agency. | the third and final meeting of a coordinated research programme on the diagnosis and management of thyroid disorders was held in vienna from 15 to 17 december 1986. the participants were from czechoslovakia, egypt, israel, malaysia and thailand. each participant had studied between 500 and 1000 patients for thyroid function evaluation by performing t3, t4 and tsh radioimmunoassays. each had also used the newly available supersensitive immunoradiometric (irma) assay in a group of patients to comp ... | 1988 | 3386976 |
| studies on thyroid activity in deoxycorticosterone-salt and goldblatt two-kidney, one-clip hypertensive rats. | in this paper we studied the role of thyroid gland function in two experimental hypertension models with different pathophysiological mechanisms: deoxycorticosterone-salt (doca-salt, volume dependent) and goldblatt 2-kidney, 1-clip (2k1c, renin dependent). doca-salt hypertensive rats showed lower t3 and t4 serum levels by the third week of induced hypertension. goldblatt 2k1c hypertensive rats, however, exhibited normal values for both hormones. treatment with thyroxine accelerated the evolution ... | 1988 | 3389048 |
| iodothyronine deiodination in rats with severe non-thyroidal illness. | to investigate the iodothyronine metabolism in non-thyroidal illness (nti), thyroidectomized male wistar rats bearing the hypercalcemic walker sarcoma 256 were substituted with, respectively, 2.3 and 11.5 mumol t4/100 g body weight by daily ip injection. serum t4 and t3 concentrations of euthyroid and hyperthyroid tumor-bearing animals markedly decreased to a nadir at day 8 after tumor implantation: serum t4 fell to, respectively, 43% (euthyroid) and 26% (hyperthyroid) of initial values, serum t ... | 1988 | 3389049 |
| impaired transport of thyroid hormones into livers of obese (ob/ob) mice. | obese (ob/ob) mice exhibit impaired hepatic thyroid hormone action that is mediated, at least in part, by a reduced nuclear 3,5,3'-triiodothyronine (t3) receptor occupancy. the possibility that lowered occupancy in obese mice may be caused by decreased transport of t3 across the hepatic plasma membrane was examined by measuring the unidirectional influx of [125i]t3 into livers of 8- to 10-wk-old obese and lean mice using a tissue-sampling portal vein-injection technique. influx of [125i]thyroxin ... | 1988 | 3389405 |
| three-compartmental analysis of effects of d-propranolol on thyroid hormone kinetics. | tracer thyroxine (t4), 3.3',5-triiodothyronine (t3), and 3,3',5'-triiodothyronine (rt3) kinetic studies were performed in normal t4 substituted subjects before and during oral d-propranolol treatment to determine whether changes in thyroid hormone metabolism in a propranolol-induced low-t3 syndrome result from inhibition of 5'-deiodination or inhibition of transport of iodothyronines into tissues. data were analyzed according to a three-compartmental model of distribution and metabolism. t4 plas ... | 1988 | 3389407 |
| early development of the thyroid axis in the brattleboro rat. | plasma concentrations of thyrotrophin (tsh), thyroxine (t4), and triiodothyronine (t3), and pituitary tsh concentrations were determined at weekly intervals during the first 42 days following birth in brattleboro homozygous (di), brattleboro heterozygous (hz), and long-evans (le) rats. offspring from matings of brattleboro rats were divided into di and hz animal subgroups on the basis of hypothalamic vasopressin content. in control le rats, circulating levels of tsh, t4, and t3, and pituitary ts ... | 1988 | 3390493 |
| equilibrium dialysis studies of plasma binding of thyroxine, triiodothyronine and their glucuronide and sulfate conjugates in human and cat plasma. | binding of thyroxine (t4), triiodothyronine (t3) and their glucuronide and sulfate conjugates, t4g, t3g, t4s and t3s, was assessed by equilibrium dialysis in plasma from 6 euthyroid humans and 5 euthyroid cats. in humans, the dialyzable percentages of t4, t4g and t4s were 0.029 +/- 0.003 (mean +/- s.d.), 0.14 +/- 0.04 and 0.08 +/- 0.02 respectively. for t3, t3g and t3s they were 0.31 +/- 0.04, 0.33 +/- 0.07 and 0.22 +/- 0.02. in cats, the corresponding values for t4, t4g and t4s were 0.057 +/- 0 ... | 1988 | 3391138 |
| spectral analysis of sphenoidal evoked potentials predicts epileptic focus. | sphenoidal evoked potentials (speps) were recorded in 14 patients with intractable temporal lobe epilepsy. twelve patients had electrographically proven unilateral seizure onset (five left, seven right). two patients had partial complex seizures and unilateral mesial temporal lobe lesions shown by magnetic resonance imaging (mri). thirteen patients subsequently underwent temporal lobectomy. speps were recorded using the p3 tonal oddball paradigm from sphenoidal electrodes referenced to scalp ele ... | 1988 | 3391148 |
| effect of thyroxine replacement therapy on the growth patterns of body, brain, and cerebellum in the neonatal hypothyroid rat. | the reversibility of the effects of propylthiouracil induced neonatal hypothyroidism by daily subcutaneous injections of l-thyroxine (t4) was investigated in the rat. four groups of rat pups were used in this experiment: group i (control) received equivalent amounts of saline subcutaneously; group ii (hypothyroid) received propylthiouracil injections daily; group iii (t4-14) are hypothyroid rats who received daily t4 replacement therapy (2.5 micrograms/day) subcutaneously starting on day 14; gro ... | 1988 | 3391252 |
| severe sexual impairment produced by morbid obesity. report of a case. | a 45-year-old man, was admitted for investigation of severe sexual impairment. during 20 years of marriage, he had had no normal sexual intercourse and the couple was childless. physical examination disclosed a severely obese man (weight 300 kg, height 1.75 m), with a relatively small and invaginated penis and small (5 ml) soft testes. laboratory examinations disclosed the following: low serum testosterone (1 ng/ml), with a reduced response to hcg (3.8 ng/ml). sex hormone binding globulin was at ... | 1988 | 3391734 |
| pre-radiation chemotherapy for infants and poor prognosis children with medulloblastoma. | beginning in 1984, we started a prospective study to evaluate the role of postoperative, pre-radiation chemotherapy in the treatment of infants and poor prognosis children with medulloblastoma. the study was designed to evaluate the role of pre-radiation chemotherapy in two specific patient populations: (a) children under the age of 2 years in which there was an attempt to delay definitive radiation and thus reduce the risk of toxicity to the developing nervous system; and (b) children over age ... | 1988 | 3391815 |
| [clinical studies on endometrial cancer]. | one hundred and fifty-two cases with endometrial carcinoma were treated in our clinic between 1973 and 1985. the average age was 55.89 years, and the age range was from 29 to 76 years. thirty-six cases (23.7%) were nulligravidas and 42 cases (27.6%) were nulliparas. one hundred and ten cases (72.4%) were postmenopausal and the average age at menopause was 49.1 years. the most frequent chief complaint was atypical genital bleeding which was noted in 128 cases (84.2%). the result of a cytologic ex ... | 1988 | 3392437 |
| [cerebral mri in the study of prognostic factors in aids. hypotheses from tests on 15 patients]. | in an attempt to determine factors of predictive value in hiv (human immuno-deficiency virus) seropositive patients, particular attention was payed to symptoms indicating early involvement of the central nervous system (cns). a cohort of healthy carriers was thus constituted. follow-up will be carried out every six month including clinical, biological as well as cns imaging by nmr. among the first 15 of them, abnormalities could be observed in 4 individuals. lesions consisted in nodules of high ... | 1988 | 3392692 |
| bacteriophage t4 genes sp and 40 apparently are the same. | the bacteriophage t4 spackle gene, which maintains host membrane integrity, mapped at the same position as gene 40 (head morphogenesis). the cloned spackle gene complemented and cross-reactivated a gene 40 mutant. like the spackle mutant, gene 40 mutants were defective in genetic exclusion. apparently, genes spackle and 40 are the same gene. | 1988 | 3392772 |
| [structural changes in proteins of the bacteriophage t4 basal plate resulting from the attachment of long fibrils]. | the effect of the attachment of long tail fibers on the structure of proteins of the bacteriophage t4 baseplate was studied by digital processing of electron microscopic images. the attachment of the long fibers was found to result in dramatical changes of the proteins of the baseplate plag, while the wedges, to which the long fibers are attached, undergo only slight changes. we studied the baseplates with one to six attached fibers and found that the attachment of one fiber resulted in the chan ... | 1988 | 3393147 |
| thyroid function as assessed by routine laboratory tests of workers with long-term lead exposure. | thyroid function was studied in 176 male workers occupationally exposed to lead. the mean blood lead concentration of the workers was 2.70 (sd 1.15, range 0.70-6.45) mumol/l. the mean duration of lead exposure was 7.6 (range 0.1-20) years. the total thyroxine (t4), free thyroxine (ft4), total triiodothyronine (t3), and thyrotropin concentrations in serum were similar in the workers in the low and high blood lead categories. in regression equations the duration of lead exposure had a weak but sig ... | 1988 | 3393853 |
| thyroid function of subjects with goitre and cretinism in an endemic goitre area of rural china after use of iodized salt. | endemic goitre and cretinism are still a public health problem in china. an epidemiological survey showed that about 5% of the inhabitants in daxin village, henan province, had goitre or cretinism after an iodized salt prevention programme had been carried out for two decades. the main food for the inhabitants of this area has an iodine content less than 30 nmol/kg and the water for cooking and drinking has an iodine concentration between 7-12 nmol/l. we studied thyroid function in subjects of t ... | 1988 | 3394475 |
| update of the wiskott-aldrich syndrome. from a new case report. | after presenting the case of a male patient who was diagnosed as suffering from the wiskott-aldrich syndrome at the age of 4 months, we review the main clinical (infections, bleeding and eczema), immunological (deficiency of igm, normal igg, elevated iga and ige, deficiency of total t lymphocytes, normal t4 levels, decreased levels of t8, diminished response to phytohemagglutinin and partial depletion of the lymphocyte population in biopsies of lymph nodes and spleen) and haematological (thrombo ... | 1988 | 3394592 |
| propylthiouracil, but not other antithyroid treatments, lengthens hamster circadian period. | two experiments were performed to evaluate the role of the thyroid gland as a mediator of circadian rhythms in the hamster. in experiment 1, the antithyroid drug propylthiouracil (ptu) lengthened the circadian period (tau), increased thyroid weight, and eliminated detectable thyroxine (t4) and triiodothyronine (t3) from blood. a low-iodine diet greatly reduced t4 levels but had no effect on t3 or tau. treatment with 500 microci of 131i failed to alter any parameter of physiology or rhythmicity m ... | 1988 | 3394831 |
| occult thyroid dysfunction in patients with refractory depression. | assessment of metabolic rate was useful in evaluating refractory depression in six of 15 women. five of the six had normal levels of t3 and t4; however, each had an elevated thyrotropin-stimulating hormone level or a low metabolic rate. the depressions responded to medication with thyroid hormone. | 1988 | 3394853 |
| hematologic indexes in men attending an infertility clinic. | to assess whether oligospermia in infertile men might be associated with abnormalities of another rapidly dividing cell population, namely, blood cells, we studied retrospectively hematologic indexes in 72 unselected men initially attending an infertility clinic and 119 healthy controls. red cell and platelet parameters were similar in the two groups. the infertility clinic patients had significantly reduced total leukocyte counts (5818 +/- 179 versus 6397 +/- 174 per mm3; p less than 0.05). thi ... | 1988 | 3395162 |
| [neurophysiological study of peripheral nerves in newborn infants with congenital hypothyroidism. value in the surveillance of replacement therapy]. | the authors studied prospectively with electrophysiological means, peripheral nerve maturation of 18 neonates with congenital hypothyroidism compared to 18 controls. before replacement therapy, a large reduction of sural nerve action potential amplitude and of hoffmann's reflex was observed. it was accompanied by a moderate reduction in nerve conduction velocity. these results imply a myelinic and even more an axonal pathology. it is related to the anatomical type of hypothyroidism and to serum ... | 1988 | 3395192 |
| glutathione deficiency and peripheral metabolism of thyroid hormones during dietary cysteine deprivation in rats. | 1. for a period of 24 d, young rats received a diet containing 120 g casein/kg or the same basic diet supplemented with 1.93 g cysteine/kg. 2. the thyroxine (t4) turnover was decreased in rats receiving the cysteine-deficient diet compared with that of rats on the supplemented diet. moreover, the extrathyroidal t4 pool and t4 disposal rate decreased. 3. cysteine deprivation also decreased the peripheral metabolism of 3,5,3'-triiodothyronine (t3). the t3 distribution space, extrathyroidal pool of ... | 1988 | 3395604 |
| carbohydrate feeding increases total body and specific tissue 3,5,3'-triiodothyronine neogenesis in the rat. | the glucose-fed rat, in contrast to the chow-fed animal, has a higher serum total t3 concentration and an increase in the hepatic content of t4 5'-deiodinase (type i) activity. the mechanism and significance of these glucose-induced changes in t3 metabolism are elucidated in this study. to focus on extrathyroidal thyroid hormone metabolism the kinetic parameters were determined in thyroidectomized t4-replaced rats (1.25 micrograms t4/100 g bw.day). kinetics of t4 and t3 were studied separately b ... | 1988 | 3396499 |
| thyroxine 5'-deiodination in brown adipose tissue and pineal gland: implications for thermogenic regulation and role of melatonin. | t4 type ii 5'-deiodinase (5'-d ii) activity was studied in wild-captured richardson's ground squirrels. as previously reported for other species, 5'-d ii activity was detected in frontal cortex, cerebellum, pineal gland, and brown adipose tissue (bat); in the median eminence the levels of 5'-d ii activity were undetectable with our methodology. when pineal gland, frontal cortex, and cerebellum nyctohemeral profiles were studied, none of them showed variations. cold exposure for 4 h led to an inc ... | 1988 | 3396504 |