Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
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| epstein-barr virus (ebv)-bamhi-a rightward transcript (bart)-6 and cellular microrna-142 synergistically compromise immune defense of host cells in ebv-positive burkitt lymphoma. | background this study was designed to explore the molecular mechanism underlying the effect of cellular mirnas and ebv mirna upon the expression of targets such as pten, and their involvement in the pathogenesis of burkitt lymphoma. material and methods in this study, we examined several differentially expressed cellular mirnas in ebv-positive versus ebv-negative burkett lymphoma tissue samples, and confirmed pten as targets of cellular mir-142 by using a bioinformatics tool, luciferase reporter ... | 2016 | 27796281 |
| epstein-barr virus micrornas reduce immune surveillance by virus-specific cd8+ t cells. | infection with epstein-barr virus (ebv) affects most humans worldwide and persists life-long in the presence of robust virus-specific t-cell responses. in both immunocompromised and some immunocompetent people, ebv causes several cancers and lymphoproliferative diseases. ebv transforms b cells in vitro and encodes at least 44 micrornas (mirnas), most of which are expressed in ebv-transformed b cells, but their functions are largely unknown. recently, we showed that ebv mirnas inhibit cd4(+) t-ce ... | 2016 | 27698133 |
| reply to the letter to the editor 'epstein-barr virus reactivation in extranodal natural killer/t-cell lymphoma patients: a previously unrecognized serious adverse event in a pilot study with romidepsin, histone deacetylase (hdac) inhibitors when combined with a proteasome inhibitor are safe and effective in patients with extranodal natural killer/t-cell lymphoma' by tan et al. | 2016 | 27502713 | |
| epstein-barr virus-positive diffuse large b-cell lymphoma involving the colon in a patient with ulcerative pancolitis and polymyositis on long-term methotrexate therapy. | the link between immunosuppressive therapy and increased lymphoma risk is well established in patients with solid organ transplantation. epstein-barr virus-positive (ebv) diffuse large b-cell lymphoma (dlbcl) is known to be a complication in patients receiving methotrexate for rheumatoid arthritis, and the risk of lymphoma in inflammatory bowel disease (ibd) has raised concerns regarding the lymphoproliferative potential of immunomodulatory therapy. in this report, we describe a case of ebv-posi ... | 2016 | 27785332 |
| epstein-barr virus-associated acute liver failure present in a 67-year-old immunocompetent female. | acute liver failure (alf) is a rare illness with a high mortality rate. the only favorable management is emergent liver transplantation. about 13% of alf cases have no clear etiology. epstein-barr virus (ebv)-associated alf accounts for less than 1% of all alf cases, and is seen mostly in adults younger than 40 years. there are only a few cases of ebv-associated alf in elderly immunocompromised adults. we report a case of alf in an immunocompetent 67-year-old woman caused by ebv infection that w ... | 2016 | 27785330 |
| [a case of chronic active epstein-barr virus infection with concomitant giant coronary artery aneurysm]. | 2016 | 27784484 | |
| [infection status and prognosis analysis of epstein-barr virus in patients with newly diagnosed hodgkin's lymphoma]. | to investigate the epstein barr virus(ebv) positive rate in newly diagnosed hodgkin's lymphoma(hl) and the prognostic significance of ebv status. | 2016 | 27784366 |
| posttransplant lymphoproliferative disorder manifesting as intestinal epstein-barr virus-positive anaplastic large-cell lymphoma in an adult renal transplant recipient. | posttransplant lymphoproliferative disorder is a relatively common posttransplant malignancy affecting as many as 10% of all solid-organ recipients. most cases of posttransplant lymphoproliferative disorder are of b-cell origin, with common epstein-barr virus association. posttransplant lymphoproliferative disorders of t-cell origin are much rarer and less frequently associated with epstein-barr virus. here, we report an unusual case of epstein-barr virus-positive anaplastic large-cell lymphoma ... | 2016 | 27805515 |
| protein stabilization improves stat3 function in autosomal dominant hyper-ige syndrome. | autosomal dominant hyper-ige syndrome (ad-hies) is caused by dominant-negative mutations in stat3; however, the molecular basis for mutant stat3 allele dysfunction is unclear and treatment remains supportive. we hypothesized that ad-hies mutations decrease stat3 protein stability and that mutant stat3 activity can be improved by agents that increase chaperone protein activity. we used computer modeling to characterize the effect of stat3 mutations on protein stability. we measured stat3 protein ... | 2016 | 27799162 |
| expression of epstein-barr virus among oral potentially malignant disorders and oral squamous cell carcinomas in the south indian tobacco-chewing population. | oral cancer is the sixth most common malignancy in the world. viruses are the causative agents of approximately 10-15% of all cancers worldwide (cancers, 6, 2014 and 2155). the tumorigenic roles of epstein-barr virus in oral cancer are unclear. literature search results are conflicting and dependent on various factors such as geographical/regional variations, sociocultural lifestyles, dietary habits, chewing/smoking tobacco habit. this study is the first original observation about frequency of e ... | 2016 | 27704636 |
| humoral markers of active epstein-barr virus infection associate with anti-extractable nuclear antigen autoantibodies and plasma galectin-3 binding protein in systemic lupus erythematosus. | we investigated if signs of active epstein-barr virus and cytomegalovirus infections associate with certain autoantibodies and a marker of type i interferon activity in patients with systemic lupus erythematosus. igm and igg plasma levels against epstein-barr virus early antigen diffuse and cytomegalovirus pp52 were applied as humoral markers of ongoing/recently active epstein-barr virus and cytomegalovirus infections, respectively. plasma galectin-3 binding protein served as a surrogate marker ... | 2016 | 27084029 |
| second malignant neoplasm following childhood cancer: a nested case-control study of a recent cohort (1987-2004) from the childhood cancer registry of the rhône-alpes region in france. | from a population-based cohort of cases of first cancers diagnosed between 1987 and 2004, before the patient's age of 15 years, the authors conducted a nested case-control study, matching 64 patients who experienced a second malignant neoplasm (smn) with 190 controls. smns comprised 10 leukemia or myelodysplastic syndromes, 5 lymphomas induced by epstein-barr virus after allograft, and 49 solid tumors, including mainly 25 carcinomas (17 of the thyroid), 9 bone sarcomas, and 7 central nervous sys ... | 2016 | 27687523 |
| spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from epstein-barr virus. | in vitro and clinical studies suggest that the oncogene lmp1 (latent membrane protein 1) encoded by epstein-barr virus (ebv) plays a role in the development of nasopharyngeal carcinoma (npc) and the formation of metastases in immunocompetent individuals. however, whether lmp1 itself is sufficient to drive these events in immunocompetent hosts remains elusive due to the lack of appropriate experimental models. the aim of this study was to study lmp1-dependent tumorigenesis and metastasis in balb/ ... | 2016 | 27793268 |
| perturbing purinergic signaling: a pathogen's guidebook to counteracting inflammatory responses. | in this issue of the biomedical journal, we learn how bacteria and parasites alike counteract inflammatory signaling by manipulating purinergic signaling. we also focus on an original article shedding light on the role of an epstein-barr virus encoded gene in metastasis in nasopharyngeal carcinoma. finally, we learn about a possible link between trichomonas vaginalis and recurrent urinary tract infection. | 2016 | 27793264 |
| acute pancreatitis associated with everolimus after kidney transplantation: a case report. | acute pancreatitis (ap) following kt is a rare and often fatal complication of the early post-transplant period. common causative factors for ap are rare after kt; anti-rejection drugs as cya, prednisone and mmf have been implicated, although evidence is not strong and we found no reports on possible causative role for mtor inhibitors. | 2016 | 27793122 |
| a case of epstein-barr virus-associated hemophagocytic lymphohistiocytosis with severe cardiac complications. | hemophagocytic lymphohistiocytosis (hlh) is a life threatening hematological disorder associated with severe systemic inflammation caused by an uncontrolled and ineffective immune response resulting in cytokine storm. epstein-barr virus (ebv) is the most common infectious agent in patients with the viral-associated hlh. limited numbers of cases with cardiac complication have been demonstrated in other viral-associated hlh patients. herein, we report a pediatric case of severe ebv-associated hlh ... | 2016 | 27793118 |
| lmp1 signaling pathway activates irf4 in latent ebv infection and a positive circuit between pi3k and src is required. | interferon (ifn) regulatory factors (irfs) have crucial roles in immune regulation and oncogenesis. we have recently shown that irf4 is activated through c-src-mediated tyrosine phosphorylation in virus-transformed cells. however, the intracellular signaling pathway triggering src activation of irf4 remains unknown. in this study, we provide evidence that epstein-barr virus (ebv) latent membrane protein 1 (lmp1) promotes irf4 phosphorylation and markedly stimulates irf4 transcriptional activity, ... | 2016 | 27819673 |
| modulation of mir-185-5p expression by ebv-mir-bart6 contributes to developmental differences in abcg4 gene expression in human megakaryocytes. | immune thrombocytopenia (itp) is an acquired autoimmune disorder characterized by low platelet count and bleeding, and is usually triggered by viral infections. we previously reported that 14 viral micrornas of megakaryocytes cultured with serum from patients with itp, including ebv-mir-bart6, are up-regulated. previous research has reported that ebv-mir-bart6 down-regulated the expression of mir-185-5p. we therefore predicted that the abcg4 gene, which is highly expressed in megakaryocyte proge ... | 2016 | 27816548 |
| establishment and characterization of a novel hodgkin lymphoma cell line, am-hlh, carrying the epstein-barr virus genome integrated into the host chromosome. | we describe the establishment and characterization of a cell line, am-hlh, obtained from a patient with epstein-barr virus-positive (ebv(+) ) nodular sclerosis-type hodgkin lymphoma (hl). the cells were positive for cd2 and cd30 and negative for cd15. the immunoglobulin heavy- and κ light-chain genes were rearranged. the karyotype was of the triploid range. southern blotting using the ebv terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental hl material. ... | 2016 | 27813134 |
| programmed death-ligand 1 expression, microsatellite instability, epstein-barr virus, and human papillomavirus in nasopharyngeal carcinomas of patients from the philippines. | most nasopharyngeal carcinomas (npcs) in a high-incidence population are driven by epstein-barr virus (ebv) infection. ebv-associated malignancies have increased expression of the programmed death-ligand 1 (pd-l1). immunotherapy agents targeting the pd-1/pd-l1 pathway have achieved durable treatment effects in patients with various cancer types including ebv-associated malignancies. in this study, we sought to investigate pd-l1 expression in a cohort of patients with npcs from the philippines. f ... | 2016 | 27807760 |
| aggressive b-cell lymphomas: frequency, immunophenotype, and genetics in a reference laboratory population. | diffuse large b-cell lymphoma (dlbcl) is the most common type of lymphoma worldwide. the current world health organization classification includes several subtypes based on a combination of clinical, immunohistochemical, and genetic differences. other aggressive variants of b-cell lymphomas, including burkitt lymphoma and double-hit lymphomas are part of the differential diagnosis and often have overlapping features with dlbcl. in this study, we evaluated 760 of cases of dlbcl and other aggressi ... | 2016 | 27806850 |
| lymphoepithelioma-like carcinoma of breast-evaluation for epstein-barr virus-encoded rna, human papillomavirus, and markers of basal cell differentiation. | this is a largest series of 5 cases of lymphoepithelioma-like carcinoma (lec) of the breast attempting to look at the expression of basal cytokeratins (cks), human papillomavirus, and epstein-barr virus-encoded rnas in these tumors. five cases were selected after stringent evaluation of all breast carcinomas showing dense lymphoid infiltration. histologically, all these tumors showed the typical histology except 1 tumor that showed an unusual granulomatous response. all tumors were negative for ... | 2016 | 27806845 |
| epstein-barr virus: more than 50 years old and still providing surprises. | it is more than 50 years since the epstein-barr virus (ebv), the first human tumour virus, was discovered. ebv has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. progress in the molecular analysis of ebv has revealed fundamental mechanisms of more general relevance to the oncogenic process. this timeline article highlights key milestones in the 50-year history of ebv and discusses how this virus provides a paradigm for exploiting ... | 2016 | 27687982 |
| mild form of guillain-barré syndrome in a patient with primary epstein-barr virus infection. | 2016 | 26837010 | |
| epstein-barr virus: diseases linked to infection and transformation. | epstein-barr virus (ebv) was first discovered in 1964, and was the first known human tumor virus now shown to be associated with a vast number of human diseases. numerous studies have been conducted to understand infection, propagation, and transformation in various cell types linked to human diseases. however, a comprehensive lens through which virus infection, reactivation and transformation of infected host cells can be visualized is yet to be formally established and will need much further i ... | 2016 | 27826287 |
| the early diagnosis of testicular natural killer/t-cell lymphoma. | testicular natural killer/t-cell lymphoma is a rare aggressive extranodal lymphoma associated with epstein-barr virus infection. time to diagnose is crucial as the disease is rapidly progressive and fatal. early suspicion is documented by imaging studies and testicular biopsies which are key factors for diagnosing testicular natural killer/t-cell lymphoma. however, no reports have described the results of imaging studies. in this paper, contrast-enhanced ultrasonography (ceus), fluorine-18-fuoro ... | 2016 | 27824969 |
| plasmid-based generation of induced neural stem cells from adult human fibroblasts. | direct reprogramming from somatic to neural cell types has become an alternative to induced pluripotent stem cells. most protocols employ viral expression systems, posing the risk of random genomic integration. recent developments led to plasmid-based protocols, lowering this risk. however, these protocols either relied on continuous presence of a variety of small molecules or were only able to reprogram murine cells. we therefore established a reprogramming protocol based on vectors containing ... | 2016 | 27822179 |
| patterns of failure and survival in patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy in saudi arabia. | we aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (imrt) combined with chemotherapy. | 2016 | 27822060 |
| tet2 functions as a resistance factor against dna methylation acquisition during epstein-barr virus infection. | extensive dna methylation is observed in gastric cancer with epstein-barr virus (ebv) infection, and ebv infection is the cause to induce this extensive hypermethylaton phenotype in gastric epithelial cells. however, some 5' regions of genes do not undergo de novo methylation, despite the induction of methylation in surrounding regions, suggesting the existence of a resistance factor against dna methylation acquisition. we conducted an rna-seq analysis of gastric epithelial cells with and withou ... | 2016 | 27829228 |
| letter to the editor: regarding "neurologic complications caused by epstein-barr virus in pediatric patients". | 2016 | 27827810 | |
| epstein-barr virus associated primary intracranial leiomyoma in a patient with human immunodeficiency virus. | a leiomyoma is a low-grade tumor originating from smooth-muscle cells. primary intracranial leiomyoma is extremely rare and usually reported in immunocompromised patients. we present a case of primary intracranial leiomyoma in a 44-year-old male with a chief complaint of headache. the pathological analysis and relevant literature has been discussed. | 2016 | 27841145 |
| ebv infection and multiple sclerosis: lessons from a marmoset model. | multiple sclerosis (ms) is thought to be initiated by the interaction of genetic and environmental factors, eliciting an autoimmune attack on the central nervous system. epstein-barr virus (ebv) is the strongest infectious risk factor, but an explanation for the paradox between high infection prevalence and low ms incidence remains elusive. we discuss new data using marmosets with experimental autoimmune encephalomyelitis (eae) - a valid primate model of ms. the findings may help to explain how ... | 2016 | 27836419 |
| prognostic correlations between abo blood group and pre-treatment plasma epstein-barr virus dna in patients with nasopharyngeal carcinoma receiving intensity-modulated radiotherapy. | the objective of this study is to assess the prognostic value of abo blood group in nasopharyngeal carcinoma (npc) treated by intensity-modulated radiotherapy (imrt). | 2016 | 27835689 |
| snhg8 is identified as a key regulator of epstein-barr virus(ebv)-associated gastric cancer by an integrative analysis of lncrna and mrna expression. | the epstein-barr virus (ebv) is associated with a variety of cancers, including gastric cancer, which has one of the highest mortality rates of all human cancers. long non-coding rnas (lncrnas) have been suggested to have important causal roles in gastric cancer. however, the interaction between lncrnas and ebv has not yet been studied. to this end, we sequenced 11,311 lncrnas and 144,826 protein-coding transcripts from four types of tissue: one non-ebv-infected gastric carcinoma (ebvngc) and it ... | 2016 | 27835598 |
| molecular detection of epstein - barr virus in nasopharyngeal carcinoma among sudanese population. | nasopharyngeal carcinoma (npc) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. npc caused by an interaction between infection with ebv and environmental and genetic factors, encompasses a multistep oncogenic process. the frequency of epstein-barr virus ebv among nasopharyngeal carcinoma is well known worldwide, however, in the sudan there is barely a published dat ... | 2016 | 27833652 |
| a possible link between the epstein-barr virus infection and autoimmune thyroid disorders. | the epstein-barr virus (ebv), also known as human herpesvirus 4, is a member of the herpesviridae virus family. ebv infection can cause infectious mononucleosis (im) in the lytic phase of ebv's life cycle. past ebv infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be respo ... | 2016 | 27833448 |
| prognostic factors of methotrexate-associated lymphoproliferative disorders associated with rheumatoid arthritis and plausible application of biological agents. | to determine prognostic factors of methotrexate-associated lymphoproliferative disorder (mtx-lpd) and evaluate the efficacy and safety of biological therapy in rheumatoid arthritis (ra) complicated with mtx-lpd. | 2016 | 27846761 |
| a complicated course of acute viral induced pharyngitis, icteric hepatitis, acalculous cholecystitis, and skin rash. | this case reveals the complexities and challenges in the diagnosis of acute epstein-barr virus (ebv) infection, indicating the potential relationship between ebv infection and severe icteric hepatitis, acalculous cholecystitis, and lymphocytic vasculitis. we suggest including ebv infectious mononucleosis in the list of differential diagnoses when any of these clinical syndromes (or a combination thereof) occurs without apparent cause, especially in the presence of lymphocytosis. to our knowledge ... | 2016 | 27847520 |
| epstein-barr virus super-enhancer ernas are essential for myc oncogene expression and lymphoblast proliferation. | epstein-barr virus (ebv) super-enhancers (eses) are essential for lymphoblastoid cell (lcl) growth and survival. reanalyses of lcl global run-on sequencing (gro-seq) data found abundant enhancer rnas (ernas) being transcribed at eses. inactivation of ese components, ebv nuclear antigen 2 (ebna2) and bromodomain-containing protein 4 (brd4), significantly decreased ernas at eses -428 and -525 kb upstream of the myc oncogene transcription start site (tss). shrna knockdown of the myc -428 and -525 e ... | 2016 | 27864512 |
| chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) with intracranial epstein-barr virus infection: a case report. | chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (clippers) is an inflammatory disorder in the central nervous system (cns) with distinct clinical, radiological, and pathological features. the pathophysiology of clippers still remains unclear and the reports are quite few. although the radiological lesions were reported to be located predominantly in the pons, brachium pontis, and cerebellum, other adjacent structures such as the white matter and spin ... | 2016 | 27861371 |
| mouse model for acute epstein-barr virus infection. | epstein-barr virus (ebv) infects human b cells and drives them into continuous proliferation. two key viral factors in this process are the latent membrane proteins lmp1 and lmp2a, which mimic constitutively activated cd40 receptor and b-cell receptor signaling, respectively. ebv-infected b cells elicit a powerful t-cell response that clears the infected b cells and leads to life-long immunity. insufficient immune surveillance of ebv-infected b cells causes life-threatening lymphoproliferative d ... | 2016 | 27856754 |
| the epstein-barr virus immunoevasins bcrf1 and bplf1 are expressed by a mechanism independent of the canonical late pre-initiation complex. | subversion of host immune surveillance is a crucial step in viral pathogenesis. epstein-barr virus (ebv) encodes two immune evasion gene products, bcrf1 (viral il-10) and bplf1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. the bcrf1 and bplf1 genes are expressed during the late phase of the lytic cycle, an essential but poorly understood phase of viral gene expression. several late gene regulators recently identified in beta and gamma h ... | 2016 | 27855219 |
| epstein-barr virus lytic reactivation regulation and its pathogenic role in carcinogenesis. | epstein-barr virus (ebv) has been associated with several types of human cancers. in the host, ebv can establish two alternative modes of life cycle, known as latent or lytic and the switch from latency to the lytic cycle is known as ebv reactivation. although ebv in cancer cells is found mostly in latency, a small number of lytically-infected cells promote carcinogenesis through the release of growth factors and oncogenic cytokines. this review focuses on the mechanisms by which ebv reactivatio ... | 2016 | 27877083 |
| epstein-barr virus-associated mucocutaneous ulcer in a patient with t-cell acute lymphoblastic leukemia: importance of accurate diagnosis and conservative management. | epstein-barr virus-associated mucocutaneous ulcer (ebv-mcu) is a recently characterized entity that falls under the spectrum of ebv-lymphoproliferative disorders. first described in 2010 by dojcinov et al, it is an ebv-driven localized proliferation of b cells, occurring in mucocutaneous tissues including the skin, the oropharynx, and the gastrointestinal tract of immunosuppressed patients in the absence of an intact t-cell repertoire. typically, it has been described in elderly patients with ag ... | 2016 | 27879545 |
| pulmonary lymphomatoid granulomatosis- a case report with review of literature. | lymphomatoid granulomatosis is a rare, epstein barr virus (ebv)-associated systemic angiodestructive disorder that may progress to a diffuse large b cell lymphoma. pulmonary involvement occurs in over 90 % cases followed by kidney, skin and brain. who classifies lymphomatoid granulomatosis under the generic heading of b cell proliferations of uncertain malignant potential. radiologically, pulmonary lymphomatoid granulomatosis (plg) presents with non specific findings making histopathology the go ... | 2016 | 27872542 |
| expanding diversity in molecular structures and functions of the il-6/il-12 heterodimeric cytokine family. | the interleukin (il)-6/il-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. this cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. the members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines il-y (p28/p40), il-12 (p35/p40), il-23 (p19/p40), i ... | 2016 | 27867385 |
| viral carcinogenesis. | cancer has been recognized for thousands of years. egyptians believed that cancer occurred at the will of the gods. hippocrates believed human disease resulted from an imbalance of the four humors: blood, phlegm, yellow bile, and black bile with cancer being caused by excess black bile. the lymph theory of cancer replaced the humoral theory and the blastema theory replaced the lymph theory. rudolph virchow was the first to recognize that cancer cells like all cells came from other cells and beli ... | 2016 | 27865457 |
| ebv infection is prevalent in the adenoid and palatine tonsils in adults. | epstein-barr virus (ebv) is associated with the pathogenesis of several diseases in both adults and children. however, there have been no reports on the prevalence and amount of ebv in the adenoids of adults; thus, it is important to investigate these in the adenoids and tonsils of adults and children. in this study, 67 patients who underwent tonsillectomy or adenotonsillectomy were included and divided into two groups: adults aged ≥ 16 years (n = 35) and children aged <16 years (n = 32). patien ... | 2016 | 27864888 |
| novel mutation in dock8-hies with severe phenotype and successful transplantation. | hyper-ige syndrome (hies) due to dock8 deficiency is an autosomal recessive (ar) primary combined immunodeficiency which results in significant morbidity and mortality at a young age. different mutations in the dock8 gene can lead to variable severity of the disease. | 2016 | 27890707 |
| primary iris leiomyoma. | intraocular leiomyomas are uncommon and usually occur in the ciliary body. primary leiomyoma of the iris is both rare and a difficult diagnosis to make, given melanocytic tumors are more common and may be amelanotic. the somewhat controversial diagnosis of iris leiomyoma requires further confirmation by immunohistochemistry and electron microscopy. herein, we describe a 58-year-old man with a 2-mm round translucent pink lesion of the iris. the tumor was excised by sector iridectomy. immunohistoc ... | 2016 | 27890619 |
| angiogenic factors are associated with multiple sclerosis. | a growing body of evidence suggests that angiogenesis plays a crucial role in the pathogenesis of multiple sclerosis (ms). animal models of ms show a significant improvement when the process of angiogenesis is halted. in this study, we measured the serum levels of vascular-endothelial growth factor (vegf), soluble endoglin (seng), angiopoietin 1(ang-1), angiopoietin 2 (ang-2), and uric acid (ua) as well as serum anti-epstein-barr virus (ebv) ebna-1 igg in 50 ms patients (including 20 newly diagn ... | 2016 | 27887749 |
| epigenetic impact on ebv associated b-cell lymphomagenesis. | epigenetic modifications leading to either transcriptional repression or activation, play an indispensable role in the development of human cancers. epidemiological study revealed that approximately 20% of all human cancers are associated with tumor viruses. epstein-barr virus (ebv), the first human tumor virus, demonstrates frequent epigenetic alterations on both viral and host genomes in associated cancers-both of epithelial and lymphoid origin. the cell type-dependent different ebv latent gen ... | 2016 | 27886133 |
| epstein-barr virus associated hemophagocytic syndrome after scrub typhus infection. | there have been a small number of cases of scrub typhus-associated hemophagocytic syndrome (hps), most of which were treated successfully using adequate antibiotics. here, we report a case of epstein-barr virus (ebv)-associated hps after scrub typhus infection that was not improved using antirickettsial treatment. a 73-year-old male who had been diagnosed with scrub typhus according to an eschar and a positive serology was transferred to our institution because of a persistent fever despite 7-da ... | 2016 | 27883370 |
| novel biomarkers of nasopharyngeal carcinoma metastasis risk identified by reverse phase protein array based tumor profiling with consideration of plasma epstein-barr virus dna load. | in patients with epstein-barr virus (ebv) associated nasopharyngeal carcinoma (npc), intertumor heterogeneity causes interpatient heterogeneity in the risk of distant metastasis. we aimed to identify novel biomarkers of metastasis risk using reverse phase protein array (rppa) profiling of npc patients at risk for metastasis and considering plasma ebv dna load. | 2016 | 27883284 |
| sjögren's syndrome complicated by myeloid/natural killer cell precursor acute leukemia: case report and review of the literature. | we report a case of sjögren's syndrome (ss) complicated by myeloid/natural killer (nk) cell precursor acute leukemia (m/nkpal). a 75-year-old woman with a previous ss history for 2 years was routinely treated. peripheral blood progenitor cells were increased, and subsequent bone marrow cell morphology examination showed the presence of acute myeloid leukemia type m4. however, flow cytometry analysis revealed that cd7/cd56/cd33/cd34/hla-dr/ccd3 were all positive and myeloperoxidase- (mpo-) specif ... | 2016 | 27882252 |
| epstein-barr virus in nasopharyngeal carcinoma of guatemalan and brazilian patients. | nasopharyngeal carcinoma (npc) is highly associated with epstein-barr virus (ebv), particularly the undifferentiated nonkeratinizing subtype. prevalence of ebv in npc in countries such as guatemala and brazil has not been studied. | 2016 | 27881609 |
| id1 upregulation and foxo3a downregulation by epstein-barr virus-encoded lmp1 in hodgkin's lymphoma. | cancer-initiating cells (cics) are specialized cells that have the ability to self-renew and are multipotent. we recently demonstrated that forkhead box o3a (foxo3a)-expressing cells exhibited a cic-like potential in hodgkin's lymphoma (hl). a proportion of hl patients are infected with epstein-barr virus (ebv). ebv-encoded latent membrane protein (lmp) 1 downregulates foxo3a, suggesting that foxo3a expression may be abolished in ebv-positive hl. inhibitors of dna-binding (id) proteins are highl ... | 2016 | 27900085 |
| shared drink and a soft punch: an almost deadly combination. | injuries of the spleen in blunt abdominal trauma are common and can lead to fatal bleeding. the diagnostic of choice to determine severity and treatment is usually made in contrast-enhanced ct. in our case we used contrast-enhanced ultrasound to identify the origin of an intra-abdominal bleeding following a minor trauma in a patient with splenomegaly due to an epstein-barr virus infection. | 2016 | 27899385 |
| core binding factor (cbf) is required for epstein-barr virus ebna3 proteins to regulate target gene expression. | chip-seq performed on lymphoblastoid cell lines (lcls), expressing epitope-tagged ebna3a, ebna3b or ebna3c from ebv-recombinants, revealed important principles of ebna3 binding to chromatin. when combined with global chromatin looping data, ebna3-bound loci were found to have a singular character, each directly associating with either ebna3-repressed or ebna3-activated genes, but not with both. ebna3a and ebna3c showed significant association with repressed and activated genes. significant direc ... | 2016 | 27903901 |
| a case of cutaneous epstein-barr virus-associated diffuse large b-cell lymphoma in an angioimmunoblastic t-cell lymphoma. | 2016 | 27904290 | |
| possible mechanisms of acquisition of herpesvirus virokines. | the genomes of certain types of human and primate herpesviruses contain functional homologs of important host cytokines (il-6, il-17, and il-10), or so-called virokines. virokines can interact with immune cell receptors, transmit a signal to them, and thus switch the type of immune response that facilitates viral infection development. in this work, we have summarized possible ways of virokine origin and proposed an evolutionary scenario of virokine acquisition with involvement of retroviral coi ... | 2016 | 27914460 |
| synchronous microscopic epstein-barr virus-positive diffuse large b-cell lymphoma of the adrenal and lymphoplasmacytic lymphoma. | lymphomas arising in the adrenal are rare, and to our knowledge, 2 cases of epstein-barr virus (ebv)-positive diffuse large b-cell lymphomas (dlbcl) in an adrenal pseudocyst have been reported. we report an incidental ebv-positive dlbcl arising in an adrenal pseudocyst in a 58-year-old man with a 7-year history of lymphoplasmacytic lymphoma (lpl). the dlbcl was present in the fibrinous exudate, while the lpl resided in the cyst wall. the patient underwent de-roofing of the same cyst 3 years prev ... | 2016 | 27913781 |
| checkpoint inhibition and cellular immunotherapy in lymphoma. | hodgkin and non-hodgkin lymphoma are both good targets for immunotherapy, as they are accessible to antibodies and cell-based immunotherapy, express costimulatory molecules, and express lineage-restricted, viral, and unique tumor antigens. blockade of the programmed-death 1 (pd-1) immune checkpoint has produced very encouraging response rates in patients with hodgkin lymphoma, whereas adoptive transfer of epstein-barr virus (ebv)-specific t cells has shown clinical activity in patients with post ... | 2016 | 27913506 |
| agranulocytosis occurrence following recent acute infectious mononucleosis. | infectious mononucleosis secondary to epstein-barr virus typically follows a relatively benign and self-limited course. a small subset of individuals may develop further progression of disease including hematologic, neurologic, and cardiac abnormalities. a mild transient neutropenia occurring during the first weeks of acute infection is a common finding however in rare cases a more profound neutropenia and agranulocytosis may occur up to 6weeks following the onset of initial symptoms. we describ ... | 2016 | 27912922 |
| a 48-year-old man with leukopenia, jaundice, and skin rash after lung transplantation. | a 48-year-old african-american male subject presented with progressive fatigue, jaundice, and new-onset leukopenia 12 weeks after undergoing bilateral lung transplantation for advanced pulmonary sarcoidosis. his transplant surgery and immediate posttransplantation course were uneventful. induction immunosuppression included methylprednisolone 500 mg intraoperatively and basiliximab (anti-il-2 monoclonal antibody) on days 0 and 4 after transplantation. his maintenance immunosuppression posttransp ... | 2016 | 27938774 |
| the cytoplasmic tail domain of epstein-barr virus gh regulates membrane fusion activity through altering gh binding to gp42 and epithelial cell attachment. | epstein-barr virus (ebv) is associated with infectious mononucleosis and a variety of cancers as well as lymphoproliferative disorders in immunocompromised patients. ebv mediates viral entry into epithelial and b cells using fusion machinery composed of four glycoproteins: gb, the gh/gl complex, and gp42. gb and gh/gl are required for both epithelial and b cell fusion. the specific role of gh/gl in fusion has been the most elusive among the required herpesvirus entry glycoproteins. previous muta ... | 2016 | 27935841 |
| epstein-barr virus nuclear antigen 1 (ebna1) interacts with regulator of chromosome condensation (rcc1) dynamically throughout the cell cycle. | the epstein-barr virus (ebv) nuclear antigen 1 (ebna1) is a sequence-specific dna binding protein which plays an essential role in viral episome replication and segregation, by recruiting the cellular complex of dna replication onto the origin (orip) and by tethering the viral dna onto the mitotic chromosomes. whereas the mechanisms of viral dna replication are well documented, those involved in tethering ebna1 to the cellular chromatin are far from being understood. here, we have identified reg ... | 2016 | 27959790 |
| erratum to: molecular detection of epstein - barr virus in nasopharyngeal carcinoma among sudanese population. | [this corrects the article doi: 10.1186/s13027-016-0104-7.]. | 2016 | 27956937 |
| total synthesis and in vitro anti-tumor-promoting activities of racemic acetophenone monomers from acronychia trifoliolata. | six acetophenone derivatives, acronyculatins i (1), j (2), k (3), l (4), n (5), and o (6), were recently isolated from acronychia trifoliolata, and the structure of the known acronyculatin b (7) was revised. because of the limited quantities of isolated products as well as their structure similarity, racemic acronyculatins i-l, n, o, and b (1-7) were synthesized to confirm their structures and to obtain sufficient material for biological evaluation. trihydroxyacetophenone was converted to the ta ... | 2016 | 27933896 |
| antiviral agents for infectious mononucleosis (glandular fever). | infectious mononucleosis (im) is a clinical syndrome, usually caused by the epstein barr virus (epv), characterised by lymphadenopathy, fever and sore throat. most cases of symptomatic im occur in older teenagers or young adults. usually im is a benign self-limiting illness and requires only symptomatic treatment. however, occasionally the disease course can be complicated or prolonged and lead to decreased productivity in terms of school or work. antiviral medications have been used to treat im ... | 2016 | 27933614 |
| intrapancreatic splenule in a pancreas allograft: case report. | a 16-year-old white man was involved in a motor vehicle collision and suffered head, chest, and abdominal trauma. despite initial resuscitative efforts, he progressed to brain death and was designated to be an organ donor by his family. he had no earlier medical or surgical history and no high-risk behaviors. blood work revealed normal creatinine, liver function tests, lipase, and amylase. viral serologies were negative except for cytomegalovirus igg and epstein-barr virus nucleic acid. imaging ... | 2016 | 27932184 |
| rapidly fatal hemophagocytic lymphohistiocytosis developing within six days following deceased-donor renal transplantation: case report. | hemophagocytic lymphohistiocytosis (hlh) is an often fatal hyperinflammatory syndrome that may complicate malignancy, infection, rheumatic disease, or immunosuppression. hlh after kidney transplantation is most often triggered by infection, usually herpes viruses such as cytomegalovirus and epstein-barr virus (ebv). it usually occurs early after transplantation. we present a case of hlh triggered by reactivation of ebv that pursued a rapidly fatal course within 6 days of receiving a deceased-don ... | 2016 | 27932162 |
| primary immunodeficiencies associated with ebv-induced lymphoproliferative disorders. | primary immunodeficiency diseases (pids) are a subgroup of inherited immunological disorders that increase susceptibility to viral infections. among the range of viral pathogens involved, ebv remains a major threat because of its high prevalence of infection among the adult population and its tendency to progress to life-threatening lymphoproliferative disorders (lpds) and/or malignancy. the high mortality in immunodeficient patients with ebv-driven lpds, despite institution of diverse and often ... | 2016 | 27931829 |
| structural basis for epstein-barr virus host cell tropism mediated by gp42 and ghgl entry glycoproteins. | herpesvirus entry into host cells is mediated by multiple virally encoded receptor binding and membrane fusion glycoproteins. despite their importance in host cell tropism and associated disease pathology, the underlying and essential interactions between these viral glycoproteins remain poorly understood. for epstein-barr virus (ebv), ghgl/gp42 complexes bind hla class ii to activate membrane fusion with b cells, but gp42 inhibits fusion and entry into epithelial cells. to clarify the mechanism ... | 2016 | 27929061 |
| positive regulation of taz expression by ebv-lmp1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma. | the epstein-barr virus latent membrane protein 1 (lmp1) is an integral membrane protein. lmp1 has been reported to activate the nf-κb and mitogen-activated protein kinase pathways. however, these effects alone are unable to account for the profound oncogenic properties of lmp1. taz is one of the nuclear effectors of hippo-related pathways and highly expressed in many human tumors. here, we reported that taz was frequently expressed in lmp1-positive nasopharyngeal carcinoma. in npc cell lines, we ... | 2016 | 27926490 |
| novel epstein-barr virus-like particles incorporating gh/gl-ebna1 or gb-lmp2 induce high neutralizing antibody titers and ebv-specific t-cell responses in immunized mice. | previous epstein-barr virus (ebv) prophylactic vaccines based on the major surface glycoprotein gp350/220 as an immunogen have failed to block viral infection in humans, suggesting a need to target other viral envelope glycoproteins. in this study, we reasoned that incorporating gh/gl or gb, critical glycoproteins for viral fusion and entry, on the surface of a virus-like particle (vlp) would be more immunogenic than gp350/220 for generating effective neutralizing antibodies to prevent viral inf ... | 2016 | 27926486 |
| increased immunoglobulin g4-positive plasma cells in lymphadenoma of the salivary gland: an immunohistochemical comparison among lymphoepithelial lesions. | lymphadenoma (la) of the salivary gland, nonsebaceous type, is an uncommon benign lymphoepithelial neoplasm. the histogenesis of the lymphoid component of la is under debate as in warthin's tumor. a recent study has described immunoglobulin (ig) class switching to igg4 in a subset of warthin's tumors. the aim of this study is to evaluate igg4 status of la and presume the role of igg4 status in pathogenesis of la. | 2016 | 27941558 |
| combining an antiviral with rituximab in ebv-related haemophagocytic lymphohistiocytosis led to rapid viral clearance; and a comprehensive review. | epstein-barr virus (ebv)-related haemophagocytic lymphohistiocytosis (ebvr-hlh) has a better prognosis when the virus is rapidly cleared, but the best antiviral approach is controversial. we present a patient to whom the therapeutic standard rituximab was co-administered with valacyclovir and an hlh-specific treatment with favourable viral and clinical responses. we conducted an extensive literature review and contacted several world reference centres and experts to inquire about their approache ... | 2016 | 27941111 |
| plasmodium chabaudi infection induces aid expression in transitional and marginal zone b cells. | endemic burkitt's lymphoma (ebl) is associated with epstein-barr virus and repeated malaria infections. a defining feature of ebl is the translocation of the c-myc oncogene to the control of the immunoglobulin promoter. activation-induced cytidine deaminase (aid) has been shown to be critical for this translocation. malaria infection induces aid in germinal center b cells, but whether malaria infection more broadly affects aid activation in extrafollicular b cells is unknown. | 2016 | 27980783 |
| cord blood transplantation following reduced-intensity conditioning for epstein-barr virus-associated hemophagocytic lymphohistiocytosis during systemic lupus erythematosus treatment. | epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) is a serious disorder in which monoclonal growth of t cells infected with ebv and macrophage activation cause pancytopenia, high fever and acute liver failure. patients with chemotherapy- or immunosuppression-resistant ebv-hlh require allogeneic hematopoietic stem cell transplantation (allo-hsct), but patients who have no sibling donors may not have time to wait for an unrelated donor. in pediatric patients, there are som ... | 2016 | 27980302 |
| graves' orbitopathy, idiopathic orbital inflammatory pseudotumor and epstein-barr virus infection: a serological and molecular study. | one of the hypotheses on the pathogenesis of autoimmune diseases, including graves' disease (gd) and graves' orbitopathy (go), involves bacterial or viral infections. recently, epstein-barr virus (ebv) has been proposed to play a role in the pathogenesis of idiopathic orbital inflammatory pseudotumor (ioip) in asians. the aim of the present study was to investigate the possible association of go with ebv infection/exposure, as compared with ioip, using serum and tissue samples, as well as primar ... | 2016 | 27987077 |
| retinal vasculitis associated with epstein-barr virus infection, a case report. | to report a case of retinal vasculitis associated with epstein-barr virus infection. | 2016 | 28030457 |
| c-reactive protein/albumin ratio (car) as a prognostic factor in patients with non-metastatic nasopharyngeal carcinoma. | background: the c-reactive protein/albumin (crp/alb) ratio has recently been associated with clinical outcomes in patients suffering various types of cancer. in this retrospective study, we investigated the prognostic value of the pre-treatment crp/alb ratio (car) in non-metastatic nasopharyngeal carcinoma (npc) patients. methods: the cohort included 2685 patients with non-metastatic npc. univariate and multivariate cox proportional hazards analyses were applied to evaluate the associations of c ... | 2016 | 27994675 |
| comparison of circulating tumour cells and circulating cell-free epstein-barr virus dna in patients with nasopharyngeal carcinoma undergoing radiotherapy. | quantification of epstein-barr virus (ebv) cell-free dna (cfdna) is commonly used in clinical settings as a circulating biomarker in nasopharyngeal carcinoma (npc), but there has been no comparison with circulating tumour cells (ctcs). our study aims to compare the performance of ctc enumeration against ebv cfdna quantitation through digital pcr (dpcr) and quantitative pcr. 74 plasma samples from 46 npc patients at baseline and one month after radiotherapy with or without concurrent chemotherapy ... | 2016 | 27994225 |
| activation of sp1-mediated transcription by rta of epstein-barr virus via an interaction with mcaf1. | 2016 | 28007940 | |
| pathological mandibular fracture associated with diffuse large b-cell lymphoma in hiv-positive patient. | this article describes the occurrence of diffuse large b-cell lymphoma in a 39-year-old human immunodeficiency virus-positive patient. the patient sought medical care complaining of increased volume in the right mandibular angle and imaging tests showed an extensive radiolucency with undefined boundaries compromising the mandibular border. after the incisional biopsy, the patient had a pathological fracture in the region, which was properly treated in a second surgical procedure using a 2.4-mm r ... | 2016 | 28005758 |
| biopsy-proven case of epstein-barr virus (ebv)-associated vasculitis of the central nervous system. | a 75-year-old woman was admitted to our hospital with rapidly deteriorating consciousness disturbance. she had a 7-year history of rheumatoid arthritis (ra), which had been treated with methotrexate (mtx) and prednisolone. brain t2-weighted mri showed diffuse high-intensity lesions in the cerebral subcortical and deep white matter, bilateral basal ganglia and thalamus. a cerebrospinal fluid examination revealed elevated protein levels and positive epstein-barr virus (ebv) dna. human immunodefici ... | 2016 | 28004435 |
| a neutralized human lmp1-igg inhibits enktl growth by suppressing the jak3/stat3 signaling pathway. | latent membrane protein 1 (lmp1), which is associated with the development of different types of epstein-barr virus (ebv) related lymphoma, has been suggested to be an important oncoprotein. in this study, a human anti-lmp1 igg antibody (lmp1-igg) was constructed and characterized by elisa, western blotting (wb), affinity and immunohistochemistry (ihc) analyses. cck-8, mtt, apoptosis assays, antibody-dependent cell-mediated cytotoxicity (adcc) and cdc (complement-dependent cytotoxicity) assays w ... | 2016 | 28009988 |
| regulatory t cells in endemic burkitt lymphoma patients are associated with poor outcomes: a prospective, longitudinal study. | deficiencies in epstein-barr virus (ebv)-specific t cell immunosurveillance appear to precede the development of endemic burkitt lymphoma (ebl), a malaria-associated pediatric cancer common in sub-saharan africa. however, t cell contributions to ebl disease progression and survival have not been characterized. our objective was to investigate regulatory and inflammatory t cell responses in ebl patients associated with clinical outcomes. by multi-parameter flow cytometry, we examined peripheral b ... | 2016 | 28033393 |
| cdc grand rounds: chronic fatigue syndrome - advancing research and clinical education. | chronic fatigue syndrome (cfs) is a complex and serious illness that is often misunderstood. experts have noted that the terminology "chronic fatigue syndrome" can trivialize this illness and stigmatize persons who experience its symptoms (1). the name was coined by a group of clinicians convened by cdc in the late 1980s to develop a research case definition for the illness, which, at the time, was called chronic epstein-barr virus syndrome. the name cfs was suggested because of the characterist ... | 2016 | 28033311 |
| short-term inhibition of tert induces telomere length-independent cell cycle arrest and apoptotic response in ebv-immortalized and transformed b cells. | besides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (tert) may promote tumorigenesis through extra-telomeric functions. the possible therapeutic effects of bibr1532 (bibr), a powerful tert inhibitor, have been evaluated in different cellular backgrounds, but no data are currently available regarding epstein-barr virus (ebv)-driven b-cell malignancies. our aim was to characterize the biological effects of tert inhibition by bibr on ebv-immortalized lymphoblastoid ... | 2016 | 28032863 |
| pulmonary lymphoepithelioma-like carcinoma with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (eml4-alk) fusion gene. | a pulmonary lymphoepithelioma-like carcinoma (plelc) is similar to a lymphoepithelioma, a subtype of nasopharyngeal carcinoma and commonly associated with epstein-barr virus infection which is a rare tumour and classified in the group of "other and unclassified carcinoma" in the latest 2015 world health organization (who) classification. some reports of lymphoepithelioma-like carcinoma (lelc) have noted an epidermal growth factor receptor (egfr) mutation, whereas none have noted a mutation of th ... | 2016 | 28031835 |
| significance of interviral recombination as novel mechanism for extending viral disease repertoire. | the recent observation of interviral recombination between members of two distinct classes of dna viruses has opened the gates to a new field of human disease development. in all cases studied thus far interviral recombination is a rare event that requires special circumstances for intracellular interaction of participating viral genomes. the rarity and special requirements do not detract from the potential clinical significance of resulting recombinants, as exemplified by recombination between ... | 2016 | 28018769 |
| a rare case of hemophagocytic lymphohistiocytosis associated with parvovirus b19 infection. | hemophagocytic lymphohistiocytosis (hlh) is a rare but life-threatening syndrome resulting from excessive immune activation. secondarily, hlh is often associated with autoimmune disease, infection, and malignancy. the most common infectious trigger is epstein-barr virus (ebv) infection. hlh is rarely triggered by parvovirus b19. we discuss a case of a 62-year-old male who presented with multi-organ failure with presumed septic shock who eventually was diagnosed with hlh, with positive parvovirus ... | 2016 | 28018767 |
| combination immunosuppressive therapy including rituximab for epstein-barr virus-associated hemophagocytic lymphohistiocytosis in adult-onset still's disease. | hemophagocytic lymphopcytosis (hlh) is a life-threatening condition. it can occur either as primary form with genetic defects or secondary to other conditions, such as hematological or autoimmune diseases. certain triggering factors can predispose individuals to the development of hlh. we report the case of a 25-year-old male patient who was diagnosed with hlh in the context of adult-onset still's disease (aosd) during a primary infection with epstein-barr virus (ebv). during therapy with anakin ... | 2016 | 28018698 |
| from benign to malign in a case of cervical adenopathy in a 17-year-old adolescent: diagnostic traps. | distinguishing between benign and malign adenopathies remains a challenge and could represent a source of error in a diagnosis. we report a case of right laterocervical adenopathy in a 17-year-old teenager admitted to hospital with an episode of fever associated with dysphagia, congested pharynx, and pultaceous deposits. initially the adenopathy was considered to be secondary to a coinfection with streptococcus b-hemolytic and epstein-barr virus, as suggested by the positive bacteriological and ... | 2016 | 28018695 |
| acute gastritis associated with epstein-barr virus infection in a child. | infectious mononucleosis is epstein-barr virus (ebv) inducing a self-limiting clinical syndrome characterized by fever, sore throat, hepatosplenomegaly, and generalized lymphadenopathy. gastrointestinal symptoms of ebv infection are nonspecific and occur rarely. ebv inducing acute gastrointestinal pathology is poorly recognized without suspicion. careful consideration is needed to diagnose gastric involvement of ebv infection including gastric lymphoma, gastric cancer, and gastritis. a few recen ... | 2016 | 28018450 |
| nkg2a-expressing natural killer cells dominate the response to autologous lymphoblastoid cells infected with epstein-barr virus. | epstein-barr virus (ebv) is a human γ-herpesvirus that establishes latency and lifelong infection in host b cells while achieving a balance with the host immune response. when the immune system is perturbed through immunosuppression or immunodeficiency, however, these latently infected b cells can give rise to aggressive b cell lymphomas. natural killer (nk) cells are regarded as critical in the early immune response to viral infection, but their role in controlling expansion of infected b cells ... | 2016 | 28018364 |
| herpesviruses dutpases: a new family of pathogen-associated molecular pattern (pamp) proteins with implications for human disease. | the human herpesviruses are ubiquitous viruses and have a prevalence of over 90% in the adult population. following a primary infection they establish latency and can be reactivated over a person's lifetime. while it is well accepted that human herpesviruses are implicated in numerous diseases ranging from dermatological and autoimmune disease to cancer, the role of lytic proteins in the pathophysiology of herpesvirus-associated diseases remains largely understudies. only recently have we begun ... | 2016 | 28036046 |
| [the understanding of epstein-barr virus associated lymphoproliferative disorder]. | in recent years, there are increasing articles concerning epstein-barr virus associated lymphoproliferative disorder (ebv+ lpd), and the name of ebv+ lpd is used widely. however, the meaning of ebv+ lpd used is not the same, which triggered confusion of the understanding and obstacles of the communication. in order to solve this problem. literature was reviewed with combination of our cases to clarify the concept of ebv+ lpd and to expound our understanding about it. in general, it is currently ... | 2016 | 28056294 |