Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [epidemio-clinical aspects of bacterial acute infant pneumopathies at yalgado ouédraogo univercity health center]. | infections of low respiratory tracks represent a public health issue and are a frequent reason for antibiotic prescription . for children in africa, they are the main morbidity factor (50% of visits) and mortality (about 20% of infant mortality). actually, the antibiotherapy, mainly probabilistic, rests on the awareness of the epidemiology of the germs which are responsible in a given region, at a given period. the purpose of this study was to evaluate the epidemio-clinical aspects of bacterial ... | 2010 | 21441087 |
| [epidemio-clinical aspects of adult acute bacterial pneumonia at yalgado ouédraogo univercity health center]. | bacterial pneumopathies are low respiratory infections due to parenchyma pulmonary attack, which etiologic agent is a bacteria different from tubercular bacillus. factually, the treatment is based on a probalistic antibiotherapy. this requires awareness of the epidemiology of the germs which are responsible in a given region, at a given period. | 2010 | 21441088 |
| a survey on urinary tract infections associated with the three most common uropathogenic bacteria. | objectives: the most common uropathogenic gram negative bacteria are escherichia coli and klebsiella pneumoniae. the purpose of this study was to determine the three most frequent bacterial agents causing urinary tract infections (uti) in patients who referred to central laboratory of dr. shariati hospital, during 2 years (january 2006- december 2007).materials and methods: the registered data were checked and collected by the questionnaires as a retrospective epidemiological survey. then, the c ... | 2010 | 21977133 |
| [severe congenital neutropenia]. | severe congenital neutropenia is a primary immunodeficiency; the lack of maturation of neutrophil precursor in bone marrow and severe neutropenia are the subjacent characteristics which explain a marked susceptibility to severe and recurrent infections; bacteria and fungi are the most common etiologic agents. we report the case of an infant with severe congenital neutropenia that began at 4 days from birth with perianal abscess infections, sepsis, liver abscess, gingivitis and oral ulcers; she r ... | 2010 | 21854729 |
| role of bacteria isolates in the spoilage of fermented african oil bean seed ugba. | study was carried out to determine the spoilage association of traditionally fermented ugba, product of african oil bean seed. samples were collected from three markets within enugu metropolis in eastern nigeria. microbial population of ugba was isolated, characterized and identified. effect of time on product quality, total viable cell count and individual growth pattern of isolates was evaluated. microorganisms isolated were proteus sp., klebsiella sp., staphylococcus epidermidis, e. coli, bac ... | 2010 | 21848074 |
| [antimicrobial resistance pattern for gram-negative uropathogens isolated from hospitalised patients and outpatients in cartagena, 2005-2008]. | determining the microbial aetiology spectrum and antibiotic resistance pattern of uropathogens causing urinary tract infections in hospitalised patients and outpatients. | 2010 | 22030688 |
| resistance pattern of ciprofloxacin against different pathogens. | ciprofloxacin is a broad-spectrum antibiotic widely prescribed in clinical and hospital settings. the emergence of antimicrobial resistance against effective antibiotics is a global issue. the objective of study is the surveillance of ciprofloxacin against common pathogens. | 2010 | 22043361 |
| prevalence of uropathogens in diabetic patients and their corresponding resistance pattern: results of a survey conducted at diagnostic centers in dhaka, bangladesh. | urinary tract infection is the second most common clinical indication for empirical antibiotic treatment in primary and secondary health care settings. the incidence of diabetes mellitus throughout the world is increasing strikingly and in the long run, it has some major effects on the genitourinary system which makes diabetic patients more liable to urinary tract infection. this study is designed to reveal the distribution of uropathogens in diabetic patients according to age and sex, and corre ... | 2010 | 22043358 |
| bacteriuria and urinary retention following gynaecological surgery: comparing short vs long term catheterization. | post operative bladder drainage is important care following gynaecological surgeries. this study was done to compare the incidence of urinary retention and bacteriuria following long term versus short term catheterization. | 2010 | 21876574 |
| in-vitro activity of three brands of ceftriaxone against different clinical isolates. | ceftriaxone is an extended spectrum cephalosporin that has been used for decades for combating infections caused by wide array of pathogens and prescription of antibiotic is in favor of specific brands without realizing the potency of the brand. the in-vitro activity of three brands of ceftriaxone and various antibiotics against clinical isolates is studied. | 2010 | 22049828 |
| in vitro susceptibility test of different clinical isolates against ceftriaxone. | because of the prevailing penicillin resistance in microorganisms, broad spectrum cephalosporins are used empirically specially in developing countries. the aim of this study is to determine the susceptibility pattern of different gram positive and gram negative pathogens against third generation cephalosporin-ceftriaxone to explore the existing effectiveness of this antibiotic. | 2010 | 22043337 |
| f-fdg pet/ct as a potential valuable adjunct to mri in characterising the brodie's abscess. | chronic osteomyelitis (brodie's abscess) is essentially a problem of diagnosis, and there may be considerable difficulty in distinguishing it from other benign and malignant bone lesions. early diagnosis of brodie's abscess is deemed important as the disease has a good curative potential following an appropriate antibiotic treatment. of late, pet/ct using (18)f-fdg is taking a centre stage in the imaging of bone infection though documentation on its role in characterising the feature of brodie's ... | 2010 | 21611044 |
| antimicrobial resistance of bacterial agents of the upper respiratory tract in south indian population. | the study was aimed at determining bacterial agents of the upper respiratory tract and the susceptibility patterns of isolates to antibiotics. the throat swab samples from 250 patients suspected of upper respiratory tract infection (urti) were obtained from the general medicine outpatient department of a rural health centre of rajah muthiah medical college and hospital (rmmc and h), annamalai university, chidambaram, tamilnadu, india and inoculated in the culture medium. the bacterial infection ... | 2010 | 22247847 |
| synthesis and anti-microbial screening of novel schiff bases of 3-amino-2-methyl quinazolin 4-(3h)-one. | in the present study, novel schiff bases were synthesized by condensation of 3-amino-2-methyl quinazolin-4-(3h)-ones with different aromatic aldehydes. the 3-amino-2-methyl quinazolin-4-(3h)-one was synthesized from anthranilic acid via the 2-methyl benzoxazin-4-one. the chemical structures of the synthesized compounds were confirmed by means of infrared (ir), (1)h-nmr, (13)c-nmr, mass spectral, and elemental analysis. these compounds were screened for anti-bacterial (staphylococcus aureus atcc ... | 2010 | 22247864 |
| trends in nosocomial bloodstream infections in a burn intensive care unit: an eight-year survey. | this study was designed to evaluate the frequency and profile of bloodstream infection (bsi) in a burn intensive care unit (bicu) in tripoli, libya, from 1st january 2000 to 31st december 2007 and to determine the prevalence of different bacteria involved in such infections and their antimicrobial susceptibilities. during the eight-year study period, 995 patients were admitted to the bicu. blood cultures were collected from each septicaemic case and reviewed for age, sex, total body surface area ... | 2010 | 21991204 |
| adult liver abscess: characteristics of patients living in rural north-eastern taiwan. | this study aimed to analyse the characteristics of adult liver abscess (la) patients living in rural townships of taiwan. | 2009 | 17537193 |
| tetrahydronaphthyl azole oxime ethers: the conformationally rigid analogues of oxiconazole as antibacterials. | a series of novel (z)- and (e)-2-imidazolo-/triazolo-methyl tetrahydronaphthyl oxime ethers (7-28) were synthesized as conformationally constrained analogues of oxiconazole and evaluated for antifungal and antibacterial activities. many of these derivatives exhibited potent antibacterial activity and surprisingly none of them was active against fungal strains. the sar studies showed that imidazole oxime ethers were more active than the corresponding triazole oxime ethers. imidazole derivatives 8 ... | 2009 | 18313805 |
| [nosocomial urinary tract infections in the geriatric hospital - pathogen spectrum and resistancies]. | we examined 834 isolates of urinary cultures (26 fungi and 808 isolates from 28 bacteria) in an academic geriatric teaching hospital for microbial spectrum and resistance analysis. of the bacteria, 90% were associated to ten species. detection rate of mrsa and esbl was 1%, detection rate for pseudomonas aeruginosa, proteus species, coagulase negative staphylococci and klebsiella species were higher than in an university clinic (p < 0.001). resistency rates were high for the 10 most frequent bact ... | 2009 | 18327687 |
| changing trends in mastitis. | abstract: the global dairy industry, the predominant pathogens causing mastitis, our understanding of mastitis pathogens and the host response to intramammary infection are changing rapidly. this paper aims to discuss changes in each of these aspects. globalisation, energy demands, human population growth and climate change all affect the dairy industry. in many western countries, control programs for contagious mastitis have been in place for decades, resulting in a decrease in occurrence of st ... | 2009 | 22082032 |
| gas forming liver abscess caused by klebsiella pneumoniae. | 2009 | 21686710 | |
| streptococcus pneumoniae coinfection is correlated with the severity of h1n1 pandemic influenza. | initial reports in may 2009 of the novel influenza strain h1n1pdm estimated a case fatality rate (cfr) of 0.6%, similar to that of seasonal influenza. in july 2009, however, argentina reported 3056 cases with 137 deaths, representing a cfr of 4.5%. potential explanations for increased cfr included virus reassortment or genetic drift, or infection of a more vulnerable population. virus genomic sequencing of 26 argentinian samples representing both severe and mild disease indicated no evidence of ... | 2009 | 20046873 |
| [endogenous klebsiella pneumoniae endophthalmitis secondary to a renal abscess: a case report]. | we report the case of an 86-year-old man with unilateral panuveitis concurrent with an infectious retinal focus. the diagnosis of endogenous endophthalmitis with subretinal abscess was suggested. the biology workup and ct scan showed a renal abscess. this was caused by klebsiella pneumoniae, which was confirmed by analysis of abscess aspiration and vitrectomy samples. this paper underscores the importance of etiological assessment in infectious panuveitis and the consequences on visual outcome. | 2009 | 19769860 |
| antimicrobial and antioxidant activities of plants from northeast of mexico. | traditional medicine has a key role in health care worldwide. obtaining scientific information about the efficacy and safety of the plants from our region is one of the goals of our research group. in this report, 17 plants were selected and collected in different localities from northeast mexico. the dried plants were separated into leaves, flowers, fruit, stems, roots and bark. each part was extracted with methanol, and 39 crude extracts were prepared. the extracts were tested for their antimi ... | 2009 | 19770266 |
| characterization of a new metallo-beta-lactamase gene, bla(ndm-1), and a novel erythromycin esterase gene carried on a unique genetic structure in klebsiella pneumoniae sequence type 14 from india. | a swedish patient of indian origin traveled to new delhi, india, and acquired a urinary tract infection caused by a carbapenem-resistant klebsiella pneumoniae strain that typed to the sequence type 14 complex. the isolate, klebsiella pneumoniae 05-506, was shown to possess a metallo-beta-lactamase (mbl) but was negative for previously known mbl genes. gene libraries and amplification of class 1 integrons revealed three resistance-conferring regions; the first contained bla(cmy-4) flanked by isec ... | 2009 | 19770275 |
| achn-490, a neoglycoside with potent in vitro activity against multidrug-resistant klebsiella pneumoniae isolates. | the in vitro activity of achn-490, a novel aminoglycoside ("neoglycoside"), was evaluated against 102 multidrug-resistant (mdr) klebsiella pneumoniae strains, including a subset of 25 strains producing the kpc carbapenemase. mic50 values for gentamicin, tobramycin, and amikacin were 8 microg/ml, 32 microg/ml, and 2 microg/ml, respectively; mic90 values for the same antimicrobials were > or = 64 microg/ml, > or = 64 microg/ml, and 32 microg/ml, respectively. achn-490 showed an mic50 of 0.5 microg ... | 2009 | 19770287 |
| in vivo selection of carbapenem-resistant klebsiella pneumoniae by ompk36 loss during meropenem treatment. | we recovered a carbapenem-resistant klebsiella pneumoniae isolate h224 under in vivo meropenem selection pressure. insertional inactivation of a major porin gene, ompk36, by is5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne dha-1 ampc beta-lactamase. | 2009 | 19766430 |
| hepatocellular carcinoma associated with liver abscess. | hepatitis b and hepatitis c are highly prevalent in taiwan. chronic hepatitis patients are at high risk of progression to liver cirrhosis and hepatocellular carcinoma (hcc). however, hcc in association with liver abscess is very rare. accordingly, this study analyzed the characteristics of hcc patients with liver abscess to improve the differential diagnosis of this condition. from january 2005 to july 2007, the medical records of nine hcc patients (4 females, 5 males; mean age, 65.8 years) trea ... | 2009 | 19767259 |
| purple urine bag syndrome. | 2009 | 19767663 | |
| aetiology of bacteraemia among adult aids patients attending lagos university teaching hospital (luth), lagos, nigeria. | bacteraemia is a relatively common event in hiv-infected patients, especially in late infection. studies in africa have shown that more than 23% of aids patients have bacteraemia but there is paucity of data from nigeria. | 2009 | 19767904 |
| chemical composition and antibacterial activity of the essential oil of cordia verbenacea from the venezuelan andes. | the essential oil of cordia verbenacea d.c. (boraginaceae) that grows in mérida-venezuela was obtained by hydrodistillation from the aerial parts of the plant, yielding 0.21%. the oil was analyzed by gc-fid and gc-ms. thirty one components which made up 94.3% of the oil were identified. the most abundant constituents found were: tricyclene (23.9%), bicyclogermacrene (11.7%), germacrene d (9.9%) and beta-caryophyllene (8.2%). antibacterial activity determination was carried out according to the d ... | 2009 | 19768996 |
| enterobacteriaceae and related organisms isolated from nest run cart shelves in commercial shell egg processing facilities. | enterobacteriaceae, including salmonella, may be recovered from foods and processing facilities. high levels of enterobacteriaceae in the processing plant environment can be an indication of inadequate sanitation. this experiment was designed to determine if nest run egg carts serve as reservoirs for enterobacteriaceae. eggs that are produced by hens not housed in buildings connected to the processing plant are referred to as nest run. many of these eggs are transported to the plant on carts to ... | 2009 | 19762864 |
| invasive bacteria isolates from children with severe infections in a nigerian hospital. | little information is available about the aetiology and epidemiology of serious bacterial infections in nigeria. this study determined bacterial isolates from blood and cerebrospinal fluid (csf) of children presenting in the emergency room of a teaching hospital in nigeria. | 2009 | 19762955 |
| prognostic serum tumor necrosis factor-alpha in paediatric patients with sepsis. | to study the association of tumor necrosis factor-alpha (tnf-alpha) in paediatric patients with different etiological agents and levels of sepsis. | 2009 | 19762956 |
| the optimization of a rapid pulsed-field gel electrophoresis protocol for the typing of acinetobacter baumannii, escherichia coli and klebsiella spp. | pulsed-field gel electrophoresis (pfge) is the most common genotyping method used for the typing of a number of bacterial species. generally, investigators use their own custom-developed protocol, but a standardized pfge protocol would allow the comparison of typing results between laboratories and the tracing of strains around the country. in the present study, we optimized a pfge protocol for subtyping of acinetobacter baumannii, escherichia coli and klebsiella spp., which are commonly isolate ... | 2009 | 19762987 |
| urinary tract infection in children with nephrotic syndrome in kano, nigeria. | nephrotic syndrome is a common childhood renal disorder; the prevalence of urinary tract infection (uti) in these patients is high. the increased prevalence of uti are due to immunoglobulin loss, defective t cell function, presence of ascites and relative malnutrition. | 2009 | 19763005 |
| comparison of the bacterial community and characterization of plant growth-promoting rhizobacteria from different genotypes of chrysopogon zizanioides (l.) roberty (vetiver) rhizospheres. | molecular approaches [pcr-denaturing gradient gel electrophoresis (dgge)] were used to determine whether three different vetiver (chrysopogon zizanioides) genotypes, commercially used in brazil and considered economically important over the world, select specific bacterial populations to coexist in their rhizospheres. dgge profiles revealed that the predominant rhizospheric bacterial community hardly varies regarding the vetiver genotype. moreover, using traditional cultivation methods, bacteria ... | 2009 | 19763409 |
| in vitro activities of moxifloxacin and tigecycline against bacterial isolates associated with intraabdominal infections at a medical center in taiwan, 2001-2006. | a total of 569 nonduplicate isolates recovered from patients with community-onset or hospital-onset intraabdominal infections (iais) from 2001 to 2006 were studied. these included 28 staphylococcus aureus and 541 gram-negative isolates (33.6% escherichia coli, 29.0% klebsiella pneumoniae, 8.1% acinetobacter baumannii, and 6.3% pseudomonas aeruginosa). minimum inhibitory concentrations (mics) of the isolates to moxifloxacin, imipenem, and ciprofloxacin were determined using the agar dilution meth ... | 2009 | 19763644 |
| emergence in italy of klebsiella pneumoniae sequence type 258 producing kpc-3 carbapenemase. | 2009 | 19759220 | |
| extended spectrum beta-lactamases (esbl) in escherichia coli and klebsiella pneumoniae: trends in the hospital and community settings. | to assess the prevalence of extended spectrum beta-lactamase (esbl) producing escherichia coli and klebsiella strains in nosocomial and community-acquired infections. | 2009 | 19759493 |
| biofilm growth of individual and dual strains of klebsiella oxytoca from the dairy industry on ultrafiltration membranes. | formation of biofilms in dairy membrane plants causes membrane pore blocking, product contamination and subsequent economic loss. to investigate the biofilm growth, two klebsiella oxytoca strains, k. b006 and tr002, previously isolated from new zealand dairy membrane plants, were grown both individually and combined on three types of ultrafiltration (uf) membranes in different concentrations of whey medium in biofilm reactors (cbr 90, biosurface technologies, bozeman, usa). biofilms of both the ... | 2009 | 19760228 |
| predictors of positive sputum cultures in exacerbations of chronic obstructive pulmonary disease. | although sputum culture in patients with an acute exacerbation of copd is of uncertain value, it is routinely done. the ability to clinically identify patients likely or unlikely to yield bacterial sputum isolates would potentially reduce unnecessary tests. the objective of this study was to identify the clinical predictors of positive sputum cultures in this patient population. | 2009 | 19761538 |
| vaccination of melanoma patients with melan-a/mart-1 peptide and klebsiella outer membrane protein p40 as an adjuvant. | toll-like receptor ligands are potentially useful adjuvants for the development of clinical t cell vaccination. here we investigated the novel toll-like receptor2 ligand p40, the outer membrane protein a derived from klebsiella pneumoniae. seventeen human leukocyte antigen-a*0201 positive stage iii/iv melanoma patients were vaccinated with p40 and melan-a/mart-1 peptide subcutaneously in monthly intervals. adverse reactions were mild-to-moderate. fourteen patients received at least 8 vaccination ... | 2009 | 19752746 |
| time-dependent effects of klebsiella pneumoniae endotoxin on the pharmacokinetics of chlorzoxazone and its main metabolite, 6-hydroxychlorzoxazone, in rats: restoration of the parameters in 96 hour in kplps rats to control levels. | it has been reported that chlorzoxazone (czx) was primarily metabolized via hepatic cyp2e1 to form 6-hydroxychlorzoxazone (oh-czx) in rats, and the activity of aniline hydroxylase (a cyp2e1 marker) in the liver was significantly decreased in rats at 24 h after pretreatment with lipopolysaccharide derived from klebsiella pneumoniae (24 h kplps rats), whereas the levels were not changed at 2 h and 96 h in the kplps rats. thus, the time-dependent pharmacokinetic parameters of czx and oh-czx were ev ... | 2009 | 19753555 |
| effective strategies for prevention and control of gram-negative infections. | infections caused by gram-negative bacteria such as pseudomonas, klebsiella, proteus and acinetobacter have been a major problem in healthcare settings for many years. overlooked in government targets and unknown to patients, these infections present considerable challenges for effective infection prevention and control. key strategies for prevention and control focus on contact precautions, the management of invasive devices and maintaining a clean, dry environment to prevent the build-up of en ... | 2009 | 19753872 |
| pharmacological characterization of anaphylaxis-like shock responses induced in mice by mannan and lipopolysaccharide. | intravenous injection of lipopolysaccharide (lps, a component of the gram-negative bacterial cell-surface) or mannan (man, a component of the fungal cell-surface) into mice reportedly induces anaphylaxis-like shock (als) via complement-associated platelet degradation and platelet-activating factor (paf), respectively. however, it is unclear whether paf is involved in lps-als or whether complements and/or platelets are involved in man-als. here, using preparations of man from saccharomyces cerevi ... | 2009 | 19755175 |
| complete nucleotide sequence of pctx-m360, an intermediate plasmid between pel60 and pctx-m3, from a multidrug-resistant klebsiella pneumoniae strain isolated in china. | in this work we report the characterization of plasmid pctx-m360, isolated from a klebsiella pneumoniae strain from china and encoding the ctx-m-3 extended-spectrum beta-lactamase. sequence analysis of pctx-m360 revealed extensive similarity with pel60 and pctx-m3, two other enterobacterial plasmids of the incl/m incompatibility group. compared to pel60, pctx-m360 contains several insertions but lacks most of a 27-kb insert found in pctx-m3, suggesting that it could be an evolutionary intermedia ... | 2009 | 19752275 |
| combination of imp-4 metallo-beta-lactamase production and porin deficiency causes carbapenem resistance in a klebsiella oxytoca clinical isolate. | this study shows for the first time the mechanism of carbapenem resistance of a klebsiella oxytoca clinical isolate zc101 recovered from a zhejiang university hospital in hangzhou, china. mic values of imipenem, meropenem, and ertapenem for k. oxytoca zc101 were 16, 16, and 128 microg/ml, respectively. conjugation experiments demonstrated the transferability of a resistance determinant from k. oxytoca zc101 to escherichia coli ec600. results from isoelectric focusing, polymerase chain reactions, ... | 2009 | 19748427 |
| characterization of class 1 integrons and gene cassettes in clinical isolates of klebsiella pneumoniae from taiwan. | we surveyed the prevalence and contents of class 1 integrons in clinical klebsiella pneumoniae isolates collected from kaohsiung, taiwan, during 2 periods (1993 and 2004). class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. we found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6')-ib-cr cassette here firstly described i ... | 2009 | 19748438 |
| plasmid-borne blashv genes in klebsiella pneumoniae are associated with strong promoters. | extended-spectrum beta-lactamases (esbls) belonging to the shv family remain a major cause of esbl-positive phenotypes in klebsiella pneumoniae. the bla(shv) gene is a normal constituent of the k. pneumoniae chromosome. however, most esbl-encoding bla(shv) genes found in k. pneumoniae are plasmid borne. the objective was to determine the contribution of promoter variants to the expression of plasmid-borne bla(shv) genes. | 2009 | 19749204 |
| prevalence and antimicrobial resistance of health care associated bloodstream infections at a general hospital in saudi arabia. | to determine the trend of health care associated blood stream infection (ha-bsi) at saudi aramco medical services organization. | 2009 | 19750270 |
| in vitro activity of nemonoxacin, a novel nonfluorinated quinolone, against 2,440 clinical isolates. | the in vitro activity of nemonoxacin (tg-873870), a novel nonfluorinated quinolone, was tested against 2,440 clinical isolates. nemonoxacin was at least fourfold more active than levofloxacin and moxifloxacin against most gram-positive cocci tested (shown by the following mic(90)/range [microg/ml] values; community-associated methicillin [meticillin]-resistant staphylococcus aureus, 0.5/0.015 to 2; staphylococcus epidermidis, 0.5/0.015 to 4 for methicillin-susceptible staphylococci and 2/0.12 to ... | 2009 | 19738018 |
| influence of inoculum size and marbofloxacin plasma exposure on the amplification of resistant subpopulations of klebsiella pneumoniae in a rat lung infection model. | we tested the hypothesis that the bacterial load at the infection site could impact considerably on the pharmacokinetic/pharmacodynamic (pk/pd) parameters of fluoroquinolones. using a rat lung infection model, we measured the influence of different marbofloxacin dosage regimens on selection of resistant bacteria after infection with a low (10(5) cfu) or a high (10(9) cfu) inoculum of klebsiella pneumoniae. for daily fractionated doses of marbofloxacin, prevention of resistance occurred for an ar ... | 2009 | 19738020 |
| steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam administered by prolonged infusion in hospitalised patients. | the objective of this study was to evaluate the steady-state pharmacokinetics and pharmacodynamics of piperacillin/tazobactam, administered by prolonged infusion, in hospitalised patients requiring antimicrobial therapy. thirteen patients received 4.5 g every 8 h (q8h), infused over 4 h, and pharmacokinetic parameters were determined by non-compartmental methods. monte carlo simulations (10,000 patients) were performed to calculate the cumulative fraction of response (cfr) for seven gram-negativ ... | 2009 | 19726163 |
| comparison of the entericbio multiplex pcr system with routine culture for detection of bacterial enteric pathogens. | the entericbio system uses a multiplex pcr assay for the simultaneous detection of campylobacter spp., salmonella enterica, shigella spp., and escherichia coli o157 from feces. it combines overnight broth enrichment with pcr amplification and detection by hybridization. an evaluation of this system was conducted by comparing the results obtained with the system with those obtained by routine culture, supplemented with alternative pcr detection methods. in a study of 773 samples, routine culture ... | 2009 | 19726596 |
| use of boronic acid disk tests to detect extended- spectrum beta-lactamases in clinical isolates of kpc carbapenemase-possessing enterobacteriaceae. | we evaluated boronic acid (ba)-based methods for their ability to detect extended-spectrum beta-lactamases (esbls) among clinical isolates of kpc-producing members of the enterobacteriaceae family. a total of 155 isolates of klebsiella pneumoniae (n = 141), escherichia coli (n = 6), enterobacter aerogenes (n = 6), and klebsiella oxytoca (n = 2) genotypically confirmed to be kpc producers were analyzed. as many as 118 isolates harbored esbls (103 harbored shv-type esbls, 13 harbored ctx-m-type es ... | 2009 | 19726597 |
| pseudomembranous colitis secondary to klebsiella oxytoca. | 2009 | 19727105 | |
| extended-spectrum beta-lactamases among enterobacteriaceae isolated in a public hospital in brazil. | extended-spectrum beta-lactamases (esbl) in enterobacteria are recognized worldwide as a great hospital problem. in this study, 127 esbl-producing enterobacteriaceae isolated in one year from inpatients and outpatients at a public teaching hospital at são paulo, brazil, were submitted to analysis by pcr with specific primers for bla shv, bla tem and bla ctx-m genes. from the 127 isolates, 96 (75.6%) klebsiella pneumoniae, 12 (9.3%) escherichia coli, 8 (6.2%) morganella morganii, 3 (2.3%) proteus ... | 2009 | 19739000 |
| risk factors for and mortality of extended-spectrum-beta-lactamase-producing klebsiella pneumoniae and escherichia coli nosocomial bloodstream infections. | a case-control study, involving patients with positive blood cultures for klebsiella pneumoniae (kp) or escherichia coli (ec) ec and controls with positive blood cultures for non-esbl-kp or ec, was performed to assess risk factors for extended-spectrum-beta-lactamase (esbl) production from nosocomial bloodstream infections (bsis). mortality among patients with bsis was also assessed. the study included 145 patients (81, 59.5% with k. pneumoniae and 64, 44.1% with e. coli bsi); 51 (35.2%) isolate ... | 2009 | 19739001 |
| emergence of blakpc-containing klebsiella pneumoniae in a long-term acute care hospital: a new challenge to our healthcare system. | to characterize isolates of klebsiella pneumoniae producing kpc carbapenemase (kpc-kp) associated with an outbreak in a long-term acute care hospital (ltach) in south florida. | 2009 | 19740911 |
| genetic diversity of capsular polysaccharide biosynthesis in klebsiella pneumoniae clinical isolates. | klebsiella pneumoniae is an enteric pathogen causing community-acquired and hospital-acquired infections in humans. epidemiological studies have revealed significant diversity in capsular polysaccharide (cps) type and clinical manifestation of k. pneumoniae infection in different geographical areas of the world. we have sequenced the capsular polysaccharide synthesis (cps) region of seven clinical isolates and compared the sequences with the publicly available cps sequence data of five strains: ... | 2009 | 19744990 |
| pyrroloquinoline quinone biogenesis: demonstration that pqqe from klebsiella pneumoniae is a radical s-adenosyl-l-methionine enzyme. | biogenesis of pyrroloquinoline quinone (pqq) in klebsiella pneumoniae requires the expression of six genes (pqqa-f). one of these genes (pqqe) encodes a 43 kda protein (pqqe) that plays a role in the initial steps in pqq formation [veletrop, j. s., et al. (1995) j. bacteriol. 177, 5088-5098]. pqqe contains two highly conserved cysteine motifs at the n- and c-termini, with the n-terminal motif comprised of a cx(3)cx(2)c consensus sequence that is unique to a family of proteins known as radical s- ... | 2009 | 19746930 |
| multidrug-resistant gram-negative infections: what are the treatment options? | the emergence of multidrug-resistant (mdr) gram-negative bacilli creates a challenge in the treatment of nosocomial infections. while the pharmaceutical pipeline is waning, two revived old antibacterials (colistin and fosfomycin), a newer one (tigecycline) and an 'improved' member of an existing class (doripenem) are the only therapeutic options left. the class of polymyxins, known since 1947 and represented mostly by polymyxin b and polymyxin e (colistin), has recently gained a principal role i ... | 2009 | 19747006 |
| prevalence and types of extended-spectrum beta-lactamases among urinary escherichia coli and klebsiella spp. in new zealand. | the aims of this survey were (i) to determine the prevalence of extended-spectrum beta-lactamases (esbls) among urinary escherichia coli and klebsiella spp. in new zealand (nz), (ii) to identify the relative prevalence of esbl types and (iii) to investigate clonality among esbl-producing e. coli and klebsiella spp. during a 4-week period in 2006, 86% of nz hospital and community diagnostic microbiology laboratories participated in the survey and referred isolates to the national reference labora ... | 2009 | 19748232 |
| in vitro susceptibilities of aerobic and facultative anaerobic gram-negative bacilli from patients with intra-abdominal infections worldwide from 2005-2007: results from the smart study. | smart (study for monitoring antimicrobial resistance trends) is an ongoing multiyear surveillance study to monitor worldwide antimicrobial resistance trends among aerobic and facultative anaerobic gram-negative bacilli (gnb) isolated from intra-abdominal infections. during 2005-2007, a total of 255 laboratories from 37 countries in five global regions collected intra-abdominal gnb for antimicrobial susceptibility testing using broth microdilution according to clinical and laboratory standards in ... | 2009 | 19748234 |
| inhibition of frog antimicrobial peptides by extracellular products of the bacterial pathogen aeromonas hydrophila. | to determine whether the extracellular products (ecps) from aeromonas hydrophila, a frog bacterial pathogen that is resistant to skin antimicrobial peptides of three different frog species xenopus laevis, litoria aurea and litoria raniformis, can modulate the activity of these peptides. | 2009 | 19728406 |
| characterization of a novel extended-spectrum tem-type beta-lactamase, tem-164, in a clinical strain of klebsiella pneumoniae in tunisia. | klebsiella pneumoniae ml1708 exhibited a multiresistance phenotype, including resistance to all beta-lactams tested, chloramphenicol, ciprofloxacin, nalidixic acid, tetracycline, and streptomycin. the double-disk synergy test was positive. ml1708 harbored a 50 kb conjugative plasmid that encoded a beta-lactamase of pi 5.5. the corresponding bla gene was identified by polymerase chain reaction and sequencing as a bla(tem) gene. the deduced protein sequence revealed a new variant of tem-1 beta-lac ... | 2009 | 19728777 |
| international survey of cronobacter sakazakii and other cronobacter spp. in follow up formulas and infant foods. | a coordinated survey for cronobacter and related organisms in powdered infant formula, follow up formula and infant foods was undertaken by 8 laboratories in 7 countries in recognition of and in response to the data needs identified in an fao/who call for data in order to develop global risk management guidance for these products. the products (domestic and imported) were purchased from the local market and were categorised according to their principle ingredients. a total of 290 products were a ... | 2009 | 19729216 |
| chemical composition and antimicrobial activity of the essential oil of anaphalis nubigena var. monocephala. | the essential oil composition of the aerial parts of anaphalis nubigena dc. var. monocephala (dc.) c. b. clarke collected from pindari glacier at a height of 3300 m, was analyzed by using gc and gc/ms. sixty components were identified, accounting for 95.9% of the total oil. the main constituents were alpha-guaiene (12.3%), gamma-muurolene (10.4%), gamma-cadinene (8.3%), alpha-muurolol (7.4%), alpha-gurjunene (6.0%) and alpha-bulnesene (5.8%). the oil was found to be rich in sesquiterpene hydroca ... | 2009 | 19731610 |
| structural and biochemical characterization of the interaction between kpc-2 beta-lactamase and beta-lactamase inhibitor protein. | kpc beta-lactamases hydrolyze the "last resort" beta-lactam antibiotics (carbapenems) used to treat multidrug resistant infections and are compromising efforts to combat life-threatening gram-negative bacterial infections in hospitals worldwide. consequently, the development of novel inhibitors is essential for restoring the effectiveness of existing antibiotics. the beta-lactamase inhibitor protein (blip) is a competitive inhibitor of a number of class a beta-lactamases. in this study, we chara ... | 2009 | 19731932 |
| in vitro activity of tigecycline and comparator agents against a global collection of gram-negative and gram-positive organisms: tigecycline evaluation and surveillance trial 2004 to 2007. | the tigecycline evaluation and surveillance trial began in 2004 to monitor the in vitro activity of tigecycline and comparator agents against a global collection of gram-negative and gram-positive pathogens. against gram negatives (n = 63 699), tigecycline mic(90)'s ranged from 0.25 to 2 mg/l for escherichia coli, haemophilus influenzae, acinetobacter baumannii, klebsiella oxytoca, enterobacter cloacae, klebsiella pneumoniae, and serratia marcescens (but was > or =32 for pseudomonas aeruginosa). ... | 2009 | 19733459 |
| comparative structure-function analysis of mannose-specific fimh adhesins from klebsiella pneumoniae and escherichia coli. | fimh, the adhesive subunit of type 1 fimbriae expressed by many enterobacteria, mediates mannose-sensitive binding to target host cells. at the same time, fine receptor-structural specificities of fimh from different species can be substantially different, affecting bacterial tissue tropism and, as a result, the role of the particular fimbriae in pathogenesis. in this study, we compared functional properties of the fimh proteins from escherichia coli and klebsiella pneumoniae, which are both 279 ... | 2009 | 19734306 |
| [urinary tract infections characterization in a spinal cord injury rehabilitation unit]. | urinary tract infection (uti) is a common problem among patients with spinal cord injury (sci) accounting for 50% of nosocomial infections in some international studies. there are several risk identified like: increased residual urine and bladder pressure, bladder overfilled and catheter use. protocols for uti's diagnosis and management, used in our unit, are based on criteria for bladder dysfunction of the national institute of disability and rehabilitation research (nidrr). | 2009 | 19686621 |
| genetic structure and distribution of the colibactin genomic island among members of the family enterobacteriaceae. | a genomic island encoding the biosynthesis and secretion pathway of putative hybrid nonribosomal peptide-polyketide colibactin has been recently described in escherichia coli. colibactin acts as a cyclomodulin and blocks the eukaryotic cell cycle. the origin and prevalence of the colibactin island among enterobacteria are unknown. we therefore screened 1,565 isolates of different genera and species related to the enterobacteriaceae by pcr for the presence of this dna element. the island was dete ... | 2009 | 19720753 |
| [the autoagglutination factor of plague pathogen--cross-reacting antigen]. | an antigen similar to the autoagglutination factor (af) of plague pathogen in immunochemical specificity was sought in 22 bacterial species. for this, an immunoglobulin anti-af diagnosticum that is the sheep erythrocytes sensitized with rabbit immune serum to the af preparation isolated from the plasmid-free variant of the yersinia pestis strain ev76. the bacteriological study applying a passive hemagglutination assay revealed af-like antigens not only in all study strains (n = 30) of y. pestis, ... | 2009 | 19718822 |
| [influence of synthetic antioxidants on persistence characteristics of microorganisms]. | to assess antipersistence characteristics of synthetic antioxidants belonging to class of triterpenoids. | 2009 | 19718826 |
| [influence of bifidobacteria on antilysozyme activity of microorganisms and their ability to form biofilms]. | to assess influence of bifidobacteria's exometabolites on expression of antilysozyme activity of microflora and its ability to biofilm formation. | 2009 | 19718828 |
| x-ray crystallography reveals a reduced substrate complex of udp-galactopyranose mutase poised for covalent catalysis by flavin. | the flavoenzyme uridine 5'-diphosphate galactopyranose mutase (ugm or glf) catalyzes the interconversion of udp-galactopyranose and udp-galactofuranose. the latter is a key building block for cell wall construction in numerous pathogens, including mycobacterium tuberculosis. mechanistic studies of ugm suggested a novel role for the flavin, and we previously provided evidence that the catalytic mechanism proceeds through a covalent flavin-galactose iminium. here, we describe 2.3 and 2.5 a resolut ... | 2009 | 19719175 |
| [formation of biofilms by fecal strains of enterobacteria and yeast fungi from candida genus]. | to assess the ability of bacteria and candida genus' yeast fungi from human fecal microflora to form biofilms. | 2009 | 19715202 |
| incidence and clinical relevance of bacterial contamination in preservation solution for liver transplantation. | postoperative infection is considered one of the most important causes of morbidity and mortality after liver transplantation. we prospectively studied the incidence and significance of infections in preservation solutions for liver transplantation. | 2009 | 19715863 |
| eradication of an extensive outbreak in a neonatal unit caused by two sequential klebsiella pneumoniae clones harbouring related plasmids encoding an extended-spectrum beta-lactamase. | outbreaks caused by extended-spectrum beta-lactamase (esbl)-producing klebsiella pneumoniae are difficult to control and closure of an affected unit is sometimes necessary. we describe an outbreak of esbl-producing k. pneumoniae in a 28-bed neonatal unit that began in august 2005 and lasted for seven months. weekly rectal swabs were taken from all babies admitted throughout the study period. review of all procedures, contact precautions, thorough environmental cleaning and restriction of cephalo ... | 2009 | 19716201 |
| the clinical consequences of antimicrobial resistance. | the continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. the major success of the seven-valent streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the emergence of previously minor serotypes that express multiresistance. the almost universal activity of cephalosporins and fluoroquinolones against community escherichia coli strains ha ... | 2009 | 19716760 |
| bacteriological profile and antimicrobial resistance patterns of clinical bacterial isolates in a university hospital. | the objective of this study was to determine the patterns of bacterial isolates found in blood culture of patients with bactermia in king abdul aziz university hospital in addition to determination of antibiotic resistance. a retrospective analysis of the 672 positive samples collected over the period of december 2006-december 2008. the observed mean age was 40 years with comparable distribution in both genders. 65.2% of the population were non-saudi. 65.5% of isolates were gram positive, mainly ... | 2009 | 19717107 |
| plasmid-mediated fluoroquinolone efflux pump gene, qepa, in escherichia coli clinical isolates in korea. | the qepa gene was detected in 4 (0.6%) of 621 nonduplicate escherichia coli clinical isolates collected from blood cultures in korea. three of the 4 qepa-positive isolates contained bla(ctx-m-14) and/or bla(tem-1) genes, but not the e8700 isolate. the qepa gene was successfully transferred and conferred resistance to hydrophilic quinolones, such as norfloxacin and ciprofloxacin, in the recipient. the gene was located in part of is26. two isolates were linked to the truncated rmtb gene. | 2009 | 19717263 |
| international clones of klebsiella pneumoniae and escherichia coli with extended-spectrum beta-lactamases in a czech hospital. | a 2-month survey of extended-spectrum beta-lactamase (esbl) producers was performed in a czech hospital. klebsiella pneumoniae produced shv-2, -5, or -12, escherichia coli produced ctx-m-9 or -15, and other species produced tem-92 or -132. all k. pneumoniae and e. coli isolates belonged to sequence types (sts) or clonal complexes (ccs) spread across the world (k. pneumoniae clonal complex 11 [cc11], cc14, and sequence type 101 [st101] and e. coli cc31, cc73, cc131, and cc405) and carried various ... | 2009 | 19710276 |
| attributable mortality rate for carbapenem-resistant klebsiella pneumoniae bacteremia. | to determine the attributable (direct) mortality and morbidity caused by carbapenem-resistant klebsiella pneumoniae bacteremia. | 2009 | 19712030 |
| recurrent klebsiella pneumoniae liver abscess: clinical and microbiological characteristics. | recurrent klebsiella pneumoniae liver abscesses (klas) are rarely reported. six cases of recurrent klas are characterized. most of the patients had diabetes and k1 serotype klas. all of the isolates were uniformly susceptible to cefazolin. distinct molecular fingerprints were found for the strains isolated from both primary and recurrent klas. | 2009 | 19692563 |
| extended spectrum beta-lactamases in escherichia coli & klebsiella pneumoniae & associated risk factors. | extended spectrum beta-lactamases (esbls) have emerged as a major threat worldwide with limited treatment options. the genotypes of esbl producing strains largely remain unknown in india; hence the present study was aimed to determine the occurrence of esbls in escherichia coli and klebsiella pneumoniae, their molecular types and associated risk factors in a tertiary care hospital. | 2009 | 19692752 |
| phosphoproteomics of klebsiella pneumoniae ntuh-k2044 reveals a tight link between tyrosine phosphorylation and virulence. | encapsulated klebsiella pneumoniae is the predominant causative agent of pyogenic liver abscess, an emerging infectious disease that often complicates metastatic meningitis or endophthalmitis. the capsular polysaccharide on k. pneumoniae surface was determined as the key to virulence. although the regulation of capsular polysaccharide biosynthesis is largely unclear, it was found that protein-tyrosine kinases and phosphatases are involved. therefore, the identification and characterization of su ... | 2009 | 19696081 |
| incidence, risk factors, and outcomes of klebsiella pneumoniae bacteremia. | although klebsiella pneumoniae is the second most common cause of gram-negative bloodstream infections, its epidemiology has not been defined in a nonselected population. we sought to describe the incidence of, risk factors for, and outcomes associated with k. pneumoniae bacteremia. | 2009 | 19699383 |
| a new, simple, rapid test for detection of dnase activity of microorganisms: dnase tube test. | the dnase test is a simple, economical method that has traditionally been used as a supplemental test to identify pathogenic staphylococcus. this test also aids in the differentiation of closely-related genera within the klebsiella-enterobacter-serratia division of enterobacteriaceae and several other pathogens, including screening of c. diphtheriae. currently dnase activity of microorganisms was tested using dnase agar plate methods. these tests have some drawbacks including the necessity of th ... | 2009 | 19700923 |
| production of beta-maltooligosaccharides of alpha- and delta-tocopherols by klebsiella pneumoniae and cyclodextrin glucanotransferase as anti-allergic agents. | the glycosylation of alpha- and delta-tocopherols using klebsiella pneumoniae and cyclodextrin glucanotransferase (cgtase) was investigated. k. pneumoniae converted alpha- and delta-tocopherols into the corresponding beta-glucosides in 10 and 8% yield, respectively. cgtase glycosylated alpha-tocopheryl beta-glucoside to alpha-tocopheryl beta-maltoside (51%) and alpha-tocopheryl beta-maltotrioside (35%). on the other hand, delta-tocopheryl beta-glucoside was converted into the corresponding beta- ... | 2009 | 19701147 |
| identification of a conserved chromosomal region encoding klebsiella pneumoniae type 1 and type 3 fimbriae and assessment of the role of fimbriae in pathogenicity. | type 3 fimbriae are expressed by most clinical klebsiella pneumoniae isolates and mediate adhesion to host structures in vitro. however, the role of type 3 fimbriae in k. pneumoniae virulence has not been evaluated by use of in vivo infection models. in this study, the type 3 fimbrial gene cluster (mrk) of the clinical isolate c3091 is described in detail. the mrk gene cluster was revealed to be localized in close proximity to the type 1 fimbrial gene cluster. thus, a 20.4-kb fimbria-encoding re ... | 2009 | 19703972 |
| in vitro activity of colistin (polymyxin e) against 3,480 isolates of gram-negative bacilli obtained from patients in canadian hospitals in the canward study, 2007-2008. | the in vitro activity of colistin was evaluated versus 3,480 isolates of gram-negative bacilli using clsi broth microdilution methods. the mic(90) of colistin was < or = 2 microg/ml against a variety of clinically important gram-negative bacilli, including escherichia coli, klebsiella spp., enterobacter spp., acinetobacter baumannii, and pseudomonas aeruginosa. all multidrug-resistant (n = 76) p. aeruginosa isolates were susceptible to colistin (mic, < or = 2 microg/ml). these data support a rol ... | 2009 | 19704135 |
| a new approach to study in vivo cellular metabolism using a modellistic analysis of magnetic resonance spectra. | this paper presents a novel approach to study in vivo cellular kinetics by the combined use of magnetic resonance (mr) spectroscopy and odum's system modeling, which includes the entire process of substrate degradation and product formation. the experiment was conducted directly in the mr-probe, where microorganisms (klebsiella planticola) were incubated with high (13)c-glucose and (13)c-xylose concentration. sugar consumptions and (13)c-ethanol production were followed for 17 h and mr-spectra w ... | 2009 | 19706297 |
| seizures associated with levofloxacin: case presentation and literature review. | we present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome p450 (cyp) 1a2 in this case, as well as in other cases, of levofloxacin-induced seizures. | 2009 | 19707748 |
| eric-pcr-based strain-specific detection of phenol-degrading bacteria in activated sludge of wastewater treatment systems. | to evaluate the use of enterobacterial repetitive intergenic consensus pcr (eric-pcr)-derived probes and primers to specifically detect bacterial strains in an activated sludge microbial community. | 2009 | 19708883 |
| strongyloides stercoralis hyperinfection presenting with symptoms mimicking acute exacerbation of chronic obstructive pulmonary disease. | hyperinfection syndrome with strongyloides stercoralis is not uncommon in immunocompromised patients. we present 2 fatal cases of strongyloides hyperinfection with initial presentation mimicking acute exacerbation of chronic obstructive pulmonary disease (copd). both cases had a history of copd and had received systemic steroid treatment before or during admission. the initial chest radiograph in both of these cases showed diffuse axial interstitial pattern. the sputum examinations of gram stain ... | 2009 | 19687002 |
| endogenous klebsiella endophthalmitis in a vietnamese immigrant. | 2009 | 19687101 | |
| regional dissemination of kpc-producing klebsiella pneumoniae. | production of a klebsiella pneumoniae carbapenemase (kpc) is the most common mechanism of carbapenem resistance in the united states; however, until now, kpc-producing isolates have not been found in western michigan. molecular typing of two kpc-producing k. pneumoniae isolates from michigan showed their similarity to other midwestern isolates. they were also unrelated to the dominant sequence type observed throughout the united states, multilocus sequence type 258. this could represent regional ... | 2009 | 19687250 |
| pyogenic liver abscess caused by klebsiella pneumoniae genetic serotype k1 in japan. | pyogenic liver abscess caused by klebsiella pneumoniae is an emerging disease worldwide, and we know the serotype k1 strain to be the most virulent strain. we report a japanese case of septic pyogenic liver abscess caused by k. pneumoniae genetic serotype k1. a 60-year old man presented at our hospital in a state of cardiopulmonary arrest. from the patient's chief complaint of chest pain, we suspected acute coronary syndrome, i.e., acute myocardial infarction. we used extracorporeal circulation ... | 2009 | 19688245 |