Publications
| Title | Abstract | Year(sorted descending) Filter | PMID Filter |
|---|
| [cuadruple concomitant non-bismuth therapy vs. classical triple therapy as first line therapy for helicobacter pylori infection]. | in a previous study we found that the classical triple therapy for helicobacter pylori (h. pylori) had low efficacy (under 70%) in our area. after this finding, in mid 2012 quadruple concomitant therapy started to be prescribed in our hospital. the aim of the present study is to compare the efficacy of classical triple therapy and quadruple concomitant therapy without bismuth. | 2016 | 27374029 |
| ceacam6 is upregulated by helicobacter pylori caga and is a biomarker for early gastric cancer. | early detection of gastric cancers saves lives, but remains a diagnostic challenge. in this study, we aimed to identify cell-surface biomarkers of early gastric cancer. we hypothesized that a subset of plasma membrane proteins induced by the helicobacter pylori oncoprotein caga will be retained in early gastric cancers through non-oncogene addiction. an inducible system for expression of caga was used to identify differentially upregulated membrane protein transcripts in vitro. the top hits were ... | 2016 | 27421133 |
| helicobacter pylori isolated from iranian drinking water: vaca, caga, icea, oipa and baba2 genotype status and antimicrobial resistance properties. | despite the clinical importance of helicobacter pylori in human gastric disorders, its exact route of transmission is still uncertain. based on the contentious hypothesis and findings of previous investigations, water may play an important role in the transmission of h. pylori to humans. this study was carried out to investigate the vaca, caga, oipa, icea and baba2 genotype status and antimicrobial resistance properties of h. pylori strains isolated from the drinking water samples of four major ... | 2016 | 27419049 |
| a systematic review on the association between the helicobacter pylori vaca i genotype and gastric disease. | helicobacter pylori (h. pylori) has been recognized as a cause of gastrointestinal diseases and progress of the pathology of gastrointestinal diseases is related to the genotype of h. pylori. published studies have indicated that the h. pylori vacuolating cytotoxin gene a (vaca) i1/i2 genotype is associated with peptic ulcer disease (pud) and gastric cancer (gc), but their conclusions are inconsistent. this study aimed to further assess the risk of vaca i gene for pud and/or gc. a systematic sea ... | 2016 | 27419046 |
| eradication of helicobacter pylori and gastric cancer: a systematic review and meta-analysis of cohort studies. | helicobacter pylori (h. pylori) is associated with an increased risk of gastric adenocarcinoma and gastric mucosa associated lymphoid tissue (malt) lymphoma and a decreased risk of esophageal adenocarcinoma. we aimed to assess how eradication therapy for h. pylori influences the risk of developing these cancers. | 2016 | 27416750 |
| high dose ilaprazole/amoxicillin as first-line regimen for helicobacter pylori infection in korea. | objective. the eradication rate of helicobacter pylori (h. pylori) following standard triple therapy has declined over the past few decades. this study has determined whether high dose dual therapy (ppi and amoxicillin) is adequate for eradicating h. pylori in korea. methods. this was an open-labeled study of h. pylori infected treatment-naive patients. subjects received dual therapy for 14 days: ilaprazole 40 mg tablets given twice a day and amoxicillin 750 mg tablets given 4 times a day. at th ... | 2016 | 27413365 |
| [prevalence of helicobacter pylori infection among children aged 7 to 18 years old: a school-based cross-sectional study in minhang district of shanghai in 2014]. | to study the infection rate and current infection rate of helicobacter pylori (hp) among children aged 7 to 18 years old in minhang district of shanghai. | 2016 | 27412738 |
| [prevalence of helicobacter pylori caga, vaca, and icea genotypes in children with gastroduodenal diseases]. | to investigate the prevalence of caga, vaca, and icea genotypes in the isolated strains of helicobacter pylori (h.pylori) from children with gastroduodenal diseases in jiangxi, china, as well as the association between caga, vaca, and icea genotypes and the type of gastroduodenal diseases. | 2016 | 27412545 |
| effect of maternal helicobacter pylori infection on birth weight in an urban community in uganda. | helicobacter pylori, a widespread infection particularly in developing countries has been associated with many adverse effects during pregnancy including hyperemesis gravidarum, neural tube defects in newborns, intrauterine fetal growth restriction and miscarriage. we sought to document the effects of h. pylori infection on birth weight in a low-income setting in kampala, uganda. | 2016 | 27411834 |
| mucin-type o-glycosylation in gastric carcinogenesis. | mucin-type o-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state. this review addresses the major role played by mucins and associated o-glycan structures in helicobacter pylori adhesion to the gastric mucosa and the subsequent est ... | 2016 | 27409642 |
| gastric polyp growth during endoscopic surveillance for esophageal varices or barrett's esophagus. | we recently observed patients with chronic liver disease (cld) or chronic reflux symptoms (crs) who developed gastric polyps (gps) while undergoing surveillance gastroscopies for the detection of esophageal varices or barrett's esophagus, respectively. | 2016 | 27430081 |
| influence of helicobacter pylori infection on metabolic syndrome in old chinese people. | background. h. pylori infection is one of the most common chronic infectious inflammatory diseases worldwide and is also a risk factor for atherosclerosis. patients with metabolic syndrome are known to be at increased risk for atherosclerosis. the aim of our study was to assess the effects of h. pylori infection on serum lipids, body mass index (bmi), and metabolic syndrome in old chinese people. material and method. a total of 191 (133 males and 58 females, aged 73.19 ± 11.03 years) people who ... | 2016 | 27429613 |
| cancers of the esophagus and stomach: potential mechanisms behind the beneficial influence of physical activity. | to compare findings from several recent meta-analyses showing a reduced risk of gastric and esophageal cancers in physically active individuals, to assess the magnitude of this benefit, and to seek information on potential underlying mechanisms. | 2016 | 27428674 |
| schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. | chronic helicobacter pylori infection triggers neoplastic transformation of the gastric mucosa in a small subset of patients, but the risk factors that induce progression to gastric metaplasia have not been identified. prior to cancer development, the oxyntic gastric glands atrophy and are replaced by metaplastic cells in response to chronic gastritis. previously, we identified schlafen 4 (slfn4) as a gli1 target gene and myeloid differentiation factor that correlates with spasmolytic polypeptid ... | 2016 | 27427984 |
| helicobacter pylori resistance to clarithromycin in reunion island. | the increasing resistance of helicobacter pylori to clarithromycin led to developing new eradication treatment regimens. the objective of our observational study was to determine the proportion of h. pylori strains resistant to clarithromycin in infected patients in reunion island and to suggest a first-line treatment in agreement with the local ecology. | 2016 | 27427280 |
| risk continues: very late manifestation of helicobacter pylori at gastric augmented bladder. | helicobacter pylori was previously demonstrated at gastric patch after gastrocystoplasty and a possible relationship with acid-haematuria syndrome was established after symptomatic relief by medical treatment. we present the long term outcome of a male bladder exstrophy patient after gastrocystoplasty. there was past history of bladder perforation, acid haematuria syndrome and treatment of hp and recurrent urinary tract infections, noncompliance on regular follow-up and cadaveric renal transplan ... | 2016 | 27427143 |
| [maternal infection due to helicobacter pylori does not increase the risk of the infection in the first trimester of the life of their infants]. | h. pylori infection is acquired early in childhood. however, there is little information available regarding the role of breastfeeding and neonatal acquisition of the infection. | 2016 | 27425773 |
| two cases of chronic gastritis with non-helicobacter pylori helicobacter infection. | two men, 48 and 54 years of age, were referred for medical checkups without any particular symptoms. upper gastrointestinal endoscopy showed a normal gastric body, but white marbled appearance in the lesser curvature of the gastric angle and antrum. biopsy specimens revealed relatively long and tightly coiled organisms. the two patients were diagnosed as having non-helicobacter pylori helicobacter (nhph) infection according to the findings of pathological and quantitative reverse transcription-p ... | 2016 | 27432094 |
| [the drug resistance and evolution of helicobacter pylori in adults of mainland china]. | 2016 | 27586987 | |
| [helicobacter pylori eradication and gastroesophageal reflux disease: a meta-analysis]. | to systematically evaluate whether eradication of helicobacter pylori (h.pylori) is associated with the development of endoscopic gastroesophageal reflux disease (gerd) and reflux symptoms. | 2016 | 27586980 |
| establishment of a nested-asp-pcr method to determine the clarithromycin resistance of helicobacter pylori. | to investigate clarithromycin resistance positions 2142, 2143 and 2144 of the 23srrna gene in helicobacter pylori (h. pylori) by nested-allele specific primer-polymerase chain reaction (nested-asp-pcr). | 2016 | 27433095 |
| characterization of key helicobacter pylori regulators identifies a role for arsrs in biofilm formation. | helicobacter pylori must be able to rapidly respond to fluctuating conditions within the stomach. despite this need for constant adaptation, h. pylori encodes few regulatory proteins. of the identified regulators, the ferric uptake regulator (fur), the nickel response regulator (nikr), and the two-component acid response system (arsrs) are each paramount to the success of this pathogen. while numerous studies have individually examined these regulatory proteins, little is known about their combi ... | 2016 | 27432830 |
| pharmacokinetics and safety of triple therapy with vonoprazan, amoxicillin, and clarithromycin or metronidazole: a phase 1, open-label, randomized, crossover study. | vonoprazan (tak-438) is a novel potassium-competitive acid blocker that inhibits gastric h(+), k(+)-atpase. the objectives of this study were to evaluate the influence of triple therapy with vonoprazan-amoxicillin-clarithromycin or vonoprazan-amoxicillin-metronidazole on the pharmacokinetics of each component of the triple therapies (primary) and to evaluate the safety and tolerability of vonoprazan-based triple therapies (secondary) in healthy adults. | 2016 | 27432383 |
| helicobacter pylori in cholecystectomy specimens-morphological and immunohistochemical assessment. | helicobacter pylori (h.pylori) is associated with gastritis, peptic ulcer, gastric carcinoma and gastric lymphoma. current literature describes presence of h.pylori in various extra-gastric locations and its association with many diseases. apart from the conventional location of gastric and duodenal mucosa, h.pylori have been isolated and cultured from gallbladder. | 2016 | 27437221 |
| the association between helicobacter pylori infection and body weight among children. | we performed to reveal the association between the helicobacter pylori infection and body weight among children. | 2016 | 27437187 |
| updates on the diagnosis of helicobacter pylori infection in children: what are the differences between adults and children? | helicobacter pylori infection is acquired mainly during childhood and causes various diseases such as gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue (malt) lymphoma, and iron deficiency anemia. although h. pylori infection in children differs from adults in many ways, this is often overlooked in clinical practice. unlike adults, nodular gastritis may be a pathognomonic endoscopic finding of childhood h. pylori infection. histopathological findings of gastric tissues are also ... | 2016 | 27437185 |
| antimicrobial susceptibility profiles of helicobacter pylori isolated from patients in north india. | helicobacter pylori-related gastroduodenal diseases are very common in india. antibiotic resistance to commonly used antibiotics against h. pylori is increasing very rapidly. the aim of this study was to determine the antimicrobial susceptibility patterns of h. pylori strains from india against commonly used antibiotics in h. pylori treatment. helicobacter pylori were cultured from 68 patients suffering from various gastroduodenal diseases in north india. minimum inhibitory concentrations (mics) ... | 2016 | 27436467 |
| detection of clarithromycin-resistant helicobacter pylori in clinical specimens by molecular methods: a review. | various molecular methods have been developed to rapidly detect clarithromycin (clr) resistance in helicobacter pylori isolates in clinical specimens. all of these assays for detecting clr resistance in h. pylori are based on detection of mutations in the 23s rrna gene. in this article, we summarise current knowledge regarding the detection of h. pylori clr resistance in clinical specimens by molecular tests. the available data showed that restriction fragment length polymorphism (rflp), 3'-mism ... | 2016 | 27436390 |
| survival of helicobacter pylori in the wastewater treatment process and the receiving river in michigan, usa. | contaminated water may play a key role in the transmission of helicobacter pylori, resulting in gastrointestinal diseases in humans. the wastewater treatment process is an important barrier to control the transmission of h. pylori. however, the presence and viability of h. pylori in the treatment process is not well known. in this paper, the real colony morphology of h. pylori was confirmed by two types of culture media. the survival of h. pylori through the tertiary wastewater treatment process ... | 2016 | 27441864 |
| barhl2 methylation using gastric wash dna or gastric juice exosomal dna is a useful marker for early detection of gastric cancer in an h. pylori-independent manner. | the main purpose of this study was to develop a methylation analysis pipeline by using gastric wash-derived dna and/or gastric juice-derived exosomal dna (exodna), and to evaluate its suitability for the early detection of gastric cancer (gc) in clinical settings. | 2016 | 27441821 |
| pepsinogens to distinguish patients with gastric intestinal metaplasia and helicobacter pylori infection among populations at risk for gastric cancer. | the objectives of this study were to investigate the serum pepsinogen test for the prediction of olgim (operative link on gastric intestinal metaplasia assessment) stages in first-degree relatives (fdr-gc) of patients with gastric cancer (gc) and autoimmune chronic atrophic gastritis (acag). | 2016 | 27441820 |
| assessment of risk and sero-prevalence of helicobacter pylori colonization among remote orang asli tribes in peninsula malaysia. | the epidemiology of helicobacter pylori (h. pylori) infection is related to human poverty with marked differences between developing and developed countries. socioeconomic factors and living standards are the main determinants of the age-dependent acquisition rate of h. pylori, and consequently its prevalence. the aim of this study was to assess the risk and sero-prevalence of h. pylori colonization among orang asli in peninsula malaysia. this cross-sectional study was conducted on orang asli su ... | 2016 | 27441568 |
| [prevention, early diagnosis and therapy of gastric cancer]. | 2016 | 27439829 | |
| recurrence rate of helicobacter pylori in patients with peptic ulcer five years or more after successful eradication. | infection with helicobacter pylori is highly prevalent worldwide, especially in developing countries. its presence in the gastroduodenal mucosa is related with development of peptic ulcer and other illnesses. the eradication of h. pylori improves mucosal histology in patients with peptic ulcers. | 2016 | 27438419 |
| improving protein-protein interactions prediction accuracy using protein evolutionary information and relevance vector machine model. | predicting protein-protein interactions (ppis) is a challenging task and essential to construct the protein interaction networks, which is important for facilitating our understanding of the mechanisms of biological systems. although a number of high-throughput technologies have been proposed to predict ppis, there are unavoidable shortcomings, including high cost, time intensity, and inherently high false positive rates. for these reasons, many computational methods have been proposed for predi ... | 2016 | 27452983 |
| isolation and characterization of helicobacter pylori recovered from gastric biopsies under anaerobic conditions. | helicobacter pylori can survive long incubation periods under anaerobic conditions, and should be possible to isolate under anaerobic conditions. our aim was to isolate h. pylori in anaerobic conditions, from gastric biopsies of h. pylori infected patients. | 2016 | 27452640 |
| the history of helicobacter pylori: from phylogeography to paleomicrobiology. | the study of the gastric pathogen helicobacter pylori brought us interesting data on the history of mankind. based on multi-locus sequence typing, it was possible to trace the migration of homo sapiens all around the world, and to infer the time when he went out of africa. beside these phylogeographic aspects, paleomicrobiology gave us important information on life in the neolithic period, following the discovery of ötzi, the iceman, who was living in the tyrolean alps 5200 years ago, and from w ... | 2016 | 27451940 |
| helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting parp-1-mediated non-homologous end joining of dna. | helicobacter pylori infection leads to chronic gastritis and increased risk of gastric cancer. the mechanism involves chronic inflammation. we aimed to determine the mechanism by which h. pylori infection causes telomere shortening in inflammatory gastric mucosa. gastric biopsy specimens were obtained from 20 patients with chronic gastritis or peptic ulcer caused by h. pylori infection. the specimens showed increased nf-κb and superoxide dismutase activities and elevated expressions of parp-1 an ... | 2016 | 27450718 |
| early eradication has a lower risk of peptic ulcer bleeding in helicobacter pylori-infected chronic kidney disease patients. | end stage renal disease (esrd) contributes to a higher mortality rate in peptic ulcer bleeding (pub) patients. a crucial question is whether early helicobacter pylori (h. pylori) eradication therapy is necessary for h. pylori-infected chronic kidney disease (ckd) patients. to explore whether h. pylori eradication therapy has a lower risk of pub at the pre-esrd stage than at the esrd stage. | 2016 | 27449117 |
| molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and helicobacter pylori infection. | the gastric pathogen helicobacter pylori utilizes molecular hydrogen (h2) as a respiratory substrate during colonization in the gastric mucosa. however, the link between molecular h2 and the pathogenesis of peptic-ulcer disease (pud) and non-ulcerous dyspepsia (nud) by the enzymatic activity of h. pylori still remains mostly unknown. here we provide evidence that breath h2 excretion profiles are distinctly altered by the enzymatic activity of h. pylori for individuals with nud and pud. we subseq ... | 2016 | 27448107 |
| role of the n-acetylmuramoyl-l-alanyl amidase, amia, of helicobacter pylori in peptidoglycan metabolism, daughter cell separation, and virulence. | the human gastric pathogen, helicobacter pylori, is becoming increasingly resistant to most available antibiotics. peptidoglycan (pg) metabolism is essential to eubacteria, hence, an excellent target for the development of new therapeutic strategies. however, our knowledge on pg metabolism in h. pylori remains poor. we have further characterized an isogenic mutant of the amia gene encoding a n-acetylmuramoyl-l-alanyl amidase. the amia mutant displayed long chains of unseparated cells, an impaire ... | 2016 | 27447281 |
| effectiveness of second through sixth line salvage helicobacter pylori treatment: bismuth quadruple therapy is almost always a reasonable choice. | aim. there is a paucity of data on the efficacy of empiric h. pylori treatment after multiple treatment failures. the aim of this study is to examine the efficacy of empiric salvage therapy as a second through sixth line treatment. methods. in this single gastroenterology center prospective study in montreal, canada, patients with failed h. pylori treatment were offered empiric salvage therapy based on the patients' previous antibiotic exposure. enrollment occurred after 1-5 previous failed atte ... | 2016 | 27446864 |
| nasal dissemination of a single-clone igh-rearranged conjunctival malt lymphoma through the nasolacrimal duct: a case report. | the aim of the present study was to report a rare case of single-clone, immunoglobulin heavy chain (igh)-rearranged mucosa-associated lymphoid tissue (malt) lymphoma in the conjunctiva, with nasal cavity dissemination through the nasolacrimal duct. a 24-year-old female was diagnosed with malt lymphoma of the nasal cavity at the department of otolaryngology, wan fang medical center, taipei medical university (tapei, taiwan) in october 2008. a biopsy of the relapsing conjunctival lesion revealed a ... | 2016 | 27446385 |
| impact of structural polymorphism for the helicobacter pylori caga oncoprotein on binding to polarity-regulating kinase par1b. | chronic infection with caga-positive helicobacter pylori is the strongest risk factor for atrophic gastritis, peptic ulcers, and gastric cancer. caga, the product of the caga gene, is a bacterial oncoprotein, which, upon delivery into gastric epithelial cells, binds to and inhibits the polarity-regulating kinase, partitioning-defective 1b (par1b) [also known as microtubule affinity-regulating kinase 2 (mark2)], via its caga multimerization (cm) motif. the inhibition of par1b elicits junctional a ... | 2016 | 27445265 |
| pharmacokinetic properties of oral lafutidine tablets and the effect of food on its pharmacokinetics in healthy chinese subjects. | the aim of this study was to evaluate the pharmacokinetics (pk) of single and multiple doses of oral lafutidine tablets and the effect of food on the pk properties in healthy chinese subjects. the tolerability and the effect of gender on the pk properties were also evaluated to acquire more pk information. | 2016 | 27444313 |
| helicobacter pylori infection in women with hashimoto thyroiditis: a case-control study. | an association between helicobacter pylori (h pylori) infection as environmental risk factors for hashimoto thyroiditis (ht) has been reported. we investigated this hypothesis in women in which ht is more common. serum immunoglobulin g antibodies against h pylori (enzyme-linked immunosorbent assay), caga protein (western blot assay), circulating antibodies to thyroid antigens, mainly thyroperoxidase (tpoabs) and thyroglobulin (tgabs), were tested in 101 females with ht and 111 non-ht control wom ... | 2016 | 27442635 |
| gastric precancerous conditions and helicobacter pylori infection in dyspeptic patients with or without endoscopic lesions. | in dyspeptic patients, esophagogastroduodenoscopy is often negative for visible lesions. biopsies of the normal-appearing mucosa for helicobacter pylori detection are not routinely obtained. diagnostic gain of routine biopsies is still debated. this study aimed to assess the occurrence of h. pylori infection and related gastric premalignant conditions in dyspeptic patients without visible lesions at esophagogastroduodenoscopy and whether the presence/absence of endoscopically visible lesions may ... | 2016 | 27442585 |
| relationship between the icea gene of helicobacter pylori and clinical outcomes. | the complex pathogenesis of helicobacter pylori (h. pylori) and the features of the host influence the diverse clinical outcomes. a mass of studies about virulence genes have accelerated the exploration of pathogenesis of h. pylori infection. induced by contact with epithelium gene a (icea) is one of the biggest concerned virulence genes. in this study, we explored the relationship between icea and the magnitude of the risk for clinical outcomes and the prevalence of icea-positive h. pylori in p ... | 2016 | 27462162 |
| the spectrum of gastric pathology in portal hypertension-an endoscopic and pathologic study of 550 cases. | one of the main tasks for pathologists when evaluating gastric biopsies from patients with portal hypertensive gastropathy (phg) is to examine whether there is increased mucosal vasculature as suggested by endoscopy. however, the full spectrum of pathology findings in patients with portal hypertension (phtn) is largely unknown. we systematically characterized the endoscopic and pathologic features in gastric biopsies from phtn patients (study group) and compared with those from patients without ... | 2016 | 27461830 |
| inflammasome activation by helicobacter pylori and its implications for persistence and immunity. | infection with the gram-negative pathogen helicobacter pylori is the most prevalent chronic bacterial infection affecting about 50 % of the human world population and is the main risk factor for gastric cancer development. the pro-inflammatory cytokine il-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the il-1 gene cluster resulting in increased il-1β production have been associated with increased risk for gastric cancer. recently, helicobacter pylori was post ... | 2016 | 27460807 |
| pharmacological regimens for eradication of helicobacter pylori: an overview of systematic reviews and network meta-analysis. | approximately half of the world's population is infected with helicobacter pylori (h.pylori), a bacterium shown to be linked with a series of gastrointestinal diseases. a growing number of systematic reviews (srs) have been published comparing the effectiveness of different treatments for h.pylori infection but have not reached a consistent conclusion. the objective of this study is to provide an overview of srs of pharmacological therapies for the eradication of h.pylori. | 2016 | 27460211 |
| comparison of sequential therapy and amoxicillin/tetracycline containing bismuth quadruple therapy for the first-line eradication of helicobacter pylori: a prospective, multi-center, randomized clinical trial. | the <80 % helicobacter pylori eradication rate with sequential therapy is unsatisfactory. modified bismuth quadruple therapy, replacing metronidazole with amoxicillin, could be promising because h. pylori resistance to tetracycline or to amoxicillin is relatively low. a 14-day modified bismuth quadruple protocol as first-line h. pylori treatment was compared with 10-day sequential therapy. | 2016 | 27460100 |
| influence of obesity and bariatric surgery on gastric cancer. | esophageal and gastric cancer (gc) are related to obesity and bariatric surgery. risk factors, such as gastroesophageal reflux and helicobacter pylori, must be investigated and treated in obese population. after surgery, gc reports are anecdotal and treatment is not standardized. this review aims to discuss gc related to obesity before and after bariatric surgery. | 2016 | 27458534 |
| helicobacter pylori infection may increase the risk of progression of chronic hepatitis b disease among the chinese population: a meta-analysis. | helicobacter pylori is a bacterium that infects over 50% of the human population worldwide. an increasing number of studies have demonstrated that h. pylori may cause liver diseases, and the underlying relationship between h. pylori infection and chronic hepatitis b has attracted much attention. this study aimed to examine the association between h. pylori infection and the progression of chronic hepatitis b in the chinese population. | 2016 | 27457918 |
| mucosal inducible no synthase-producing iga+ plasma cells in helicobacter pylori-infected patients. | the mucosal immune system is relevant for homeostasis, immunity, and also pathological conditions in the gastrointestinal tract. inducible no synthase (inos)-dependent production of no is one of the factors linked to both antimicrobial immunity and pathological conditions. upregulation of inos has been observed in human helicobacter pylori infection, but the cellular sources of inos are ill defined. key differences in regulation of inos expression impair the translation from mouse models to huma ... | 2016 | 27456483 |
| surveillance of levofloxacin resistance in helicobacter pylori isolates in bogotá-colombia (2009-2014). | increased resistance of helicobacter pylori to clarithromycin and metronidazole has resulted in recommendation to substitute fluoroquinolones for eradication therapy. the aims of the study were to determine the prevalence and changes in primary levofloxacin resistance related to h. pylori gyra sequences. the study utilized h. pylori strains isolated from patients undergoing gastroscopy in bogotá, colombia from 2009 to 2014. levofloxacin susceptibility was assessed by agar dilution. mutations in ... | 2016 | 27454429 |
| structure and dynamics of h. pylori 98-10 c5-cytosine specific dna methyltransferase in complex with s-adenosyl-l-methionine and dna. | helicobacter pylori is a gram-negative bacterium that inhabits the human gastrointestinal tract, and some strains of this bacterium cause gastric ulcers and cancer. dna methyltransferases (mtases) are promising drug targets for the treatment of cancer and other diseases that are also caused by epigenetic alternations of the genome. the c5-cytosine specific dna methyltransferase from h. pylori (m. hpy c5mc) catalyzes the transfer of the methyl group from the cofactor s-adenosyl-l-methionine (adom ... | 2016 | 27470658 |
| global burden of cancers attributable to infections in 2012: a synthetic analysis. | infections with certain viruses, bacteria, and parasites are strong risk factors for specific cancers. as new cancer statistics and epidemiological findings have accumulated in the past 5 years, we aimed to assess the causal involvement of the main carcinogenic agents in different cancer types for the year 2012. | 2016 | 27470177 |
| how host regulation of helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer. | the bacterial pathogen helicobacter pylori is the etiological agent of a range of gastrointestinal pathologies including peptic ulcer disease and the major killer, gastric adenocarcinoma. infection with this bacterium induces a chronic inflammatory response in the gastric mucosa (gastritis). it is this gastritis that, over decades, eventually drives the development of h. pylori-associated disease in some individuals. the majority of studies investigating h. pylori pathogenesis have focused on fa ... | 2016 | 27469367 |
| gastric mucosa-associated lymphoid tissue lymphoma and helicobacter pylori infection: a review of current diagnosis and management. | helicobacter pylori (h. pylori)-associated gastritis is one of the most common infectious diseases in the united states, china and worldwide. gastric mucosa-associated tissue lymphoma (malt lymphoma) is a rare mature b-cell neoplasm associated with h. pylori infection that is curable by antibiotics therapy alone. the pathological diagnosis of gastric malt lymphoma can be reached by histological examination, immunohistochemical staining and b-cell clonality analysis. h. pylori eradication is the ... | 2016 | 27468353 |
| effect of dietary vitamin c on gastric cancer risk in the korean population. | to investigate the effects of dietary vitamin c and foods containing vitamin c on gastric cancer risk. | 2016 | 27468215 |
| g6pd deficiency does not enhance susceptibility for acquiring helicobacter pylori infection in sardinian patients. | subjects with glucose-6-phosphate dehydrogenase (g6pd) deficiency may be more susceptible to infections due to impaired leukocyte bactericidal activity. the disorder is common in the mediterranean area. the aim of this study was to investigate whether g6pd deficiency may be a risk factor for acquiring h. pylori infection. | 2016 | 27467818 |
| structural identification of the lipopolysaccharide-binding capability of a cupin-family protein from helicobacter pylori. | we solved the crystal structure of a functionally uncharacterized protein, hp0902, from helicobacter pylori. its structure demonstrated an all-β cupin fold that cannot bind metal ions due to the absence of a metal-binding histidine that is conserved in many metallo-cupins. in contrast, isothermal titration calorimetry and nmr titration demonstrated that hp0902 is able to bind bacterial endotoxin lipopolysaccharides (lps) through its surface-exposed loops, where metal-binding sites are usually fo ... | 2016 | 27466800 |
| prevalence of h. pylori infection and atrophic gastritis in a population-based screening with serum biomarker panel (gastropanel®) in st. petersburg. | russian federation is among the high-incidence countries for gastric cancer (gc), with the incidence being projected to continue increasing. using a non-invasive blood test with four stomach-specific biomarkers (pepsinogen-i (pg-i) and -ii (pg-ii), amidated gastrin-17 (g-17) and helicobacter pylori (hp) igg antibodies) in a hospital-based screening setting, we aimed to determine the prevalence of gc risk conditions: hp-infection and atrophic gastritis (ag). | 2016 | 27466521 |
| vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. | vonoprazan, a potassium-competitive acid blocker, is expected to improve the healing of endoscopic submucosal dissection (esd)-induced gastric ulcers compared with proton pump inhibitors (ppis). | 2016 | 27464849 |
| epigenetic roles in the malignant transformation of gastric mucosal cells. | gastric carcinogenesis occurs when gastric epithelial cells transition through the initial, immortal, premalignant, and malignant stages of transformation. epigenetic regulations contribute to this multistep process. due to the critical role of epigenetic modifications , these changes are highly likely to be of clinical use in the future as new biomarkers and therapeutic targets for the early detection and treatment of cancers. here, we summarize the recent findings on how epigenetic modificatio ... | 2016 | 27464701 |
| randomized, double-blind, placebo-controlled trial to evaluate the effect of helicobacter pylori eradication on glucose homeostasis in type 2 diabetic patients. | literature data suggest an association between helicobacter pylori infection and glucose homeostasis. however, a causative link between them has not been demonstrated yet. the aim of this study is to investigate the effect of h. pylori eradication on glucose homeostasis in patients with type 2 diabetes. | 2016 | 27480449 |
| comparative evaluation of rut, pcr and elisa tests for detection of infection with cytotoxigenic h. pylori. | helicobacter pylori is one of the most prevalent infectious agents in the world which causes a variety of gastrointestinal diseases including gastritis, peptic ulcer and gastric carcinoma. the objective of this study was to comparatively evaluate invasive (rapid urease test and polymerase chain reaction) and non-invasive (enzyme-linked immunosorbent assay) tests in diagnosis of infection with cytotoxigenic h. pylori. | 2016 | 27478790 |
| effects of lactobacillus gasseri oll2716 on helicobacter pylori-associated dyspepsia: a multicenter randomized double-blind controlled trial. | some lactobacillus spp. suppress helicobacter pylori in the stomach and have potential therapeutic applications for the treatment of gastrointestinal conditions. in this study, the effects of lactobacillus strains on functional dyspepsia associated with h. pylori infection were examined. volunteers were screened using the (13)c-urea breath test (ubt) and h. pylori stool test, and 131 participants who met the selection criteria (mean age: 48.9 years) were randomly given l. gasseri oll2716-contain ... | 2016 | 27478434 |
| online registry for nationwide database of current trend of helicobacter pylori eradication in korea: interim analysis. | eradication of helicobacter pylori using first-line therapy is becoming less effective. subjects who had been treated for h. pylori infection were prospectively enrolled through an on-line database registry from october 2010 to december 2012. demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for h. pylori infection were collected. data of 3,700 patients from 34 hospitals were analyzed. the overall eradication rate ... | 2016 | 27478335 |
| the indications, applications, and risks of proton pump inhibitors. | proton pump inhibitors (ppi) are the most effective drugs for inhibiting gastric acid secretion. they have been in clinical use for more than 25 years, in 2014, 3.475 billion daily defined doses (ddd) of ppi were prescribed in germany. this high number alone calls for a critical analysis of the spectrum of indications for ppi and their potential adverse effects. | 2016 | 27476707 |
| prevalence of the colonization of helicobacter pylori among students of the school of dentistry, university of granada, spain. | the oral cavity is a reservoir for helicobacter pylori, and occupations that involve close contact with it, like dentistry, could entail a higher risk of colonization. the aim of this study was to evaluate if the length of stay at the school of dentistry of the university of granada could influence colonization by h. pylori, , and to furthermore correlate colonization by h. pylori, with the state of oral health and oral hygiene habits. | 2016 | 27475692 |
| 3-arylpropionylhydroxamic acid derivatives as helicobacter pylori urease inhibitors: synthesis, molecular docking and biological evaluation. | helicobacter pylori urease is involved in several physiologic responses such as stomach and duodenal ulcers, adenocarcinomas and stomach lymphomas. thus, inhibition of urease is taken for a good chance to treat h. pylori-caused infections, we have therefore focused our efforts on seeking novel urease inhibitors. here, a series of arylpropionylhydroxamic acids were synthesized and evaluated for urease inhibition. out of these compounds, 3-(2-benzyloxy-5-chlorophenyl)-3-hydroxypropionylhydroxamic ... | 2016 | 27492194 |
| newly arrived refugee children with helicobacter pylori are thinner than their non-infected counterparts. | the hypothesis of this study was that those refugee children with helicobacter pylori are thinner than their non-infected counterparts. this cross-sectional study investigated the height and weight of newly arrived refugee children up to age 19 years, who were screened for h. pylori using a stool antigen test at the migrant health service in adelaide between august 2010 and october 2013. of 460 children, 21% were infected with h. pylori. after adjusting for vitamin b12 and iron levels, ethnicity ... | 2016 | 27491384 |
| factors associated with detection of helicobacter pylori in gastric biopsies: a case-control study of 396 biopsies. | helicobacter pylori (hp) infection is associated with significant gastric mucosal inflammation. we aimed to determine the clinicopathologic features associated with hp in gastric biopsy. | 2016 | 27490761 |
| management of helicobacter pylori infections. | infection with helicobacter pylori is associated with severe digestive diseases including chronic gastritis, peptic ulcer disease, and gastric cancer. successful eradication of this common gastric pathogen in individual patients is known to prevent the occurrence of peptic ulcer disease and gastric cancer. | 2016 | 27520775 |
| effects of different omeprazole dosing on gastric ph in non-variceal upper gastrointestinal bleeding: a randomized prospective study. | we aimed to identify the best method of omeprazole (ome) application with respect to intragastric ph, cytochrome p450 2c19 (cyp2c19) genotype and phenotype. | 2016 | 27518195 |
| potassium-competitive acid blockers: advanced therapeutic option for acid-related diseases. | acid-related diseases (ards), such as peptic ulcers and gastroesophageal reflux disease, represent a major health-care concern. some major milestones in our understanding of gastric acid secretion and ard treatment reached during the last 50years include 1) discovery of histamine h2-receptors and development of h2-receptor antagonists, 2) identification of h(+),k(+)-atpase as the parietal cell proton pump and development of proton pump inhibitors (ppis), and 3) identification of helicobacter pyl ... | 2016 | 27514776 |
| a novel approach to helicobacter pylori pan-genome analysis for identification of genomic islands. | genomes of a given bacterial species can show great variation in gene content and thus systematic analysis of the entire gene repertoire, termed the pan-genome, is important for understanding bacterial intra-species diversity, population genetics, and evolution. here, we analyzed the pan-genome from 30 completely sequenced strains of the human gastric pathogen helicobacter pylori belonging to various phylogeographic groups, focusing on 991 accessory (not fully conserved) orthologous groups (ogs) ... | 2016 | 27504980 |
| laparoscopic repair of perforated peptic ulcer: outcome and associated morbidity and mortality. | the mainstay of treatment for perforated peptic ulcer is omental patch closure. with the advent of laparoscopic surgery, this approach is being used for the treatment of perforated peptic ulcer. the aim of this study was to evaluate the outcome of laparoscopy in firoozgar general hospital over a period of 18 months. the outcome of the laparoscopic approach and the associated morbidity and mortality, operation time, conversion rate and hospital stay were assessed. | 2016 | 27504170 |
| performance evaluation of a rapid whole-blood immunoassay for the detection of igg antibodies against helicobacter pylori in daily clinical practice. | a growing number of rapid helicobacter pylori antibody tests are commercially available now, however, some of these tests are often used without sufficient evaluation. the aim of this study was to evaluate the performance of a commercially available rapid whole-blood immunoassay (gabcontrol(®) h. pylori; gabmed gmbh, köln, germany), for the qualitative detection of igg antibodies against h. pylori with the (13)c-urea breath test ((13)c-ubt) serving as a reference method. | 2016 | 27503600 |
| characterization of tunnel mutants reveals a catalytic step in ammonia delivery by an aminoacyl-trna amidotransferase. | the helicobacter pylori asp-trna(a) (sn) /glu-trna(g) (ln) amidotransferase (gatcab) utilizes an uncommonly hydrophilic, ~ 40 å ammonia tunnel for ammonia/ammonium transport between isolated active sites. hydrophilicity of this tunnel requires a distinct ammonia transport mechanism, which hypothetically occurs through a series of deprotonation and protonation steps. to explore the initiation of this relay mechanism, the highly conserved tunnel residue d185 (in the gata subunit) was enzymatically ... | 2016 | 27500385 |
| the expression of igf-1r in helicobacter pylori-infected intestinal metaplasia and gastric cancer. | overexpression of igf-1r has been demonstrated in gastrointestinal cancers, and its expression is reported as the result of the loss of tumor suppressors. il-16 is involved in the pathophysiological process of chronic inflammatory diseases. the aim of this study is to determine the changes in the expression of igf-1r in intestinal metaplasia (im) and gastric cancer (gc) as well as the effect of helicobacter pylori (h. pylori) and il-16 on cell proliferation and igf-1r expression in gastric cells ... | 2016 | 27499580 |
| helicobacter pylori infection and risk of gastric cancer in korea: a quantitative systematic review. | in the context of the global decrease in mortality due to gastric cancer, previous studies have reported that the effect of chronic helicobacter pylori (h. pylori) infection on the incidence of gastric cancer varies among regions. this systematic review was conducted to investigate h. pylori as a risk factor for gastric cancer in korea, where the incidence of gastric cancer is among the highest in the world. | 2016 | 27499162 |
| structural insight into β-clamp and its interaction with dna ligase in helicobacter pylori. | helicobacter pylori, a gram-negative and microaerophilic bacterium, is the major cause of chronic gastritis, gastric ulcers and gastric cancer. owing to its central role, dna replication machinery has emerged as a prime target for the development of antimicrobial drugs. here, we report 2å structure of β-clamp from h. pylori (hpβ-clamp), which is one of the critical components of dna polymerase iii. despite of similarity in the overall fold of eubacterial β-clamp structures, some distinct feature ... | 2016 | 27499105 |
| helicobacter pylori infection in children with type 1 diabetes mellitus: a case-control study. | helicobacter pylori infection is one of the most common chronic bacterial infections. there is challenge on the real rate of prevalence of h. pylori in diabetic patients. this study was done to assess the prevalence of h. pylori infection in children suffering from type 1 insulin-dependent diabetes mellitus. | 2016 | 27497772 |
| clinical characteristics and prognostic factors of primary gastric lymphoma: a retrospective study with 165 cases. | primary gastric lymphoma (pgl) is the most common extranodal non-hodgkin lymphoma. this retrospective study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in patients with pgl.from january 2003 to november 2014, 165 patients who were diagnosed with pgl at west china hospital were enrolled in this study. the clinical features, treatment, and follow-up information were analyzed.in this study, diffuse large b-cell lymphoma (dlbcl) (108 ... | 2016 | 27495029 |
| estimation of salient regions related to chronic gastritis using gastric x-ray images. | since technical knowledge and a high degree of experience are necessary for diagnosis of chronic gastritis, computer-aided diagnosis (cad) systems that analyze gastric x-ray images are desirable in the field of medicine. therefore, a new method that estimates salient regions related to chronic gastritis/non-gastritis for supporting diagnosis is presented in this paper. in order to estimate salient regions related to chronic gastritis/non-gastritis, the proposed method monitors the distance betwe ... | 2016 | 27494090 |
| lack of association found between helicobacter pylori infection and diarrhea-predominant irritable bowel syndrome: a multicenter retrospective study. | aims. the association between helicobacter pylori (h. pylori) infection and diarrhea-predominant irritable bowel syndrome (ibs-d) is still controversial. here we performed a retrospective study to explore this issue. methods. a total of 502 inpatients with rome iii confirmed ibs-d and known h. pylori status from 8 hospitals were enrolled. h. pylori-positive patients, hospitalized in the recent year, were followed up to evaluate the effects of h. pylori eradication on ibs-d clinical course. resul ... | 2016 | 27493660 |
| [s2k-guideline helicobacter pylori and gastroduodenal ulcer disease]. | 2016 | 27512738 | |
| a review of the infection-associated cancers in north african countries. | cancer is typically classified as a leading non-communicable disease; however, infectious agents, such as helicobacter pylori (h. pylori), hepatitis b virus (hbv), hepatitis c virus (hcv) and human papilloma virus (hpv), contribute significantly to the pathogenesis of various cancers. less developed countries, including countries of the north african (na) region, endure the highest burden of infection-related cancers. the five most common infection-associated cancers in na in order of incidence ... | 2016 | 27512409 |
| corrigendum: food allergy and helicobacter pylori infection: a systematic review. | [this corrects the article on p. 368 in vol. 7, pmid: 27047479.]. | 2016 | 27512393 |
| tlr1 polymorphism associations with gastric mucosa morphologic patterns on magnifying nbi endoscopy: a prospective crosssectional study. | helicobacter pylori is now recognized as a causative factor of chronic gastritis, gastroduodenal ulcers, gastric cancer and mucosaassociated lymphatic tissue lymphoma. tolllike receptors are important bacterial receptors in gastric epithelial cell signaling transduction and play critical roles in gastric carcinogenesis. | 2016 | 27509981 |
| identification of a novel cassette array in integronbearing helicobacter pylori strains isolated from iranian patients. | helicobacter pylori as the second most common cause of gastric cancer in the world infects approximately half of the developed countries population and 80% of the population living in developing countries. integrons as genetic reservoirs play major roles in dissemination of antimicrobial resistance genes. to the best of our knowledge, this is the first study to report carriage of class 1 and 2 integrons and associated gene cassettes in h. pylori isolates from iran. this crosssectional study was ... | 2016 | 27509968 |
| gastric carcinoma: recent trends in diagnostic biomarkers and molecular targeted therapies. | gastric cancer is generally associated with poor survival rates and accounts for a remarkable proportion of global cancer mortality. the prevalence of gastric carcinoma varies in different regions of world and across teh various ethnic groups. on the basis of pathological assessment, gastric cancer can be categorized as intestinal and diffuse carcinomas. the etiology is diverse, including chemical carcinogen exposure, and high salt intake helicobacter pylori also plays a vital role in the pathog ... | 2016 | 27509928 |
| systematic identification of immunodominant cd4+ t cell responses to hpaa in helicobacter pylori infected individuals. | in mice, antigen-specific cd4+ t cell response is indispensible for the protective immunity against helicobacter pylori (h. pylori). it has been demonstrated that neuraminyllactose-binding hemagglutinin (hpaa) immunization protected mice from h. pylori infection in a cd4+ t cell dependent manner. however, much remains unclear concerning the human cd4+ t cell responses to hpaa. we conducted a systematic study here to explore the immunodominant, hpaa-specific cd4+ t cell responses in h. pylori inf ... | 2016 | 27509059 |
| "non-toxic" proteins of the botulinum toxin complex exert in-vivo toxicity. | the botulinum neurotoxin (bont) causes muscle paralysis and is the most potent toxin in nature. bont is associated with a complex of auxiliary "non-toxic" proteins, which constitute a large-sized toxin complex (l-tc). however, here we report that the "non-toxic" complex of serotype d botulinum l-tc, when administered to rats, exerts in-vivo toxicity on small-intestinal villi. moreover, serotype c and d of the "non-toxic" complex, but not bont, induced vacuole-formation in a rat intestinal epithe ... | 2016 | 27507612 |
| late-onset hypertrophic pyloric stenosis with gastric outlet obstruction: case report and review of the literature. | we report late-onset hypertrophic pyloric stenosis in a 17-year-old female. she presented with abdominal pain and an episode of upper gastrointestinal hemorrhage and subsequently developed gastric outlet obstruction. work-up revealed circumferential pyloric thickening, delayed gastric emptying, and a stenotic, elongated pyloric channel. biopsies showed benign gastropathy, negative for helicobacter pylori, without eosinophilic infiltrates. botulinum toxin injection provided limited relief. diagno ... | 2016 | 27506212 |
| factors associated with metachronous gastric cancer development after endoscopic submucosal dissection for early gastric cancer. | to clarify the factors associated with metachronous gastric cancer development after endoscopic submucosal dissection (esd) for early gastric cancer. | 2016 | 27505404 |
| cigarette smoking and gastric cancer in the stomach cancer pooling (stop) project. | tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. we examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'stomach cancer pooling (stop) project', including 10 290 cases and 26 145 controls. we estimated summary odds ratios (ors) and the corresponding 95% confidence intervals (cis) by pooling study-specific ors using random-effe ... | 2016 | 27560662 |